## Fri Nov 15 08:32:16 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin28/TLS_3_bin.19.fa -m mmseqs --itype genome -o TLS_3_bin.19 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/TLS_3_bin.19 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS3_k127_1003657_0	381666.H16_A2730	1.837e-72	258.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,1K0V6@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS3_k127_1009058_2	391587.KAOT1_14597	3.576e-45	171.0	COG2360@1|root,COG2360@2|Bacteria,4NG3A@976|Bacteroidetes,1HY9J@117743|Flavobacteriia	976|Bacteroidetes	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TLS3_k127_1009058_1	439235.Dalk_3200	1.098e-62	229.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2MIKY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_1009058_0	439292.Bsel_3203	7.147e-108	365.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,26NXQ@186821|Sporolactobacillaceae	91061|Bacilli	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS3_k127_1016723_0	1131553.JIBI01000039_gene1945	1.152e-111	368.0	COG1960@1|root,COG1960@2|Bacteria,1R9RG@1224|Proteobacteria,2WDMG@28216|Betaproteobacteria,3745S@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_1016723_1	261292.Nit79A3_1297	8.859e-90	304.0	COG3221@1|root,COG3221@2|Bacteria,1N92V@1224|Proteobacteria,2WBUH@28216|Betaproteobacteria,373TX@32003|Nitrosomonadales	28216|Betaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
TLS3_k127_1027121_0	886293.Sinac_3361	3.664e-76	272.0	COG0357@1|root,COG0566@1|root,COG0357@2|Bacteria,COG0566@2|Bacteria,2J158@203682|Planctomycetes	203682|Planctomycetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB,SpoU_methylase
TLS3_k127_1027121_1	1121104.AQXH01000001_gene819	2.439e-37	151.0	COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,1IR96@117747|Sphingobacteriia	976|Bacteroidetes	J	PFAM Pseudouridine synthase, RsuA and RluB C D E F	rluC	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
TLS3_k127_1027121_2	497964.CfE428DRAFT_2041	2.346e-10	72.0	COG1452@1|root,COG1452@2|Bacteria,46SJX@74201|Verrucomicrobia	74201|Verrucomicrobia	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	imp	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
TLS3_k127_1030847_1	1333998.M2A_2072	1.715e-30	125.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria,4BQCK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	ArsC family	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
TLS3_k127_1030847_0	697281.Mahau_0981	5.575e-46	175.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,42FF1@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS3_k127_1036777_0	449447.MAE_29080	2.543e-21	111.0	COG1621@1|root,COG2931@1|root,COG1621@2|Bacteria,COG2931@2|Bacteria,1G32M@1117|Cyanobacteria	1117|Cyanobacteria	Q	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PPC,VCBS
TLS3_k127_1041310_1	1238182.C882_1746	2.102e-05	54.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2JSB6@204441|Rhodospirillales	204441|Rhodospirillales	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS3_k127_1041310_0	758.BBIX01000009_gene1835	5.701e-36	143.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1Y7MZ@135625|Pasteurellales	135625|Pasteurellales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS3_k127_104695_0	717231.Flexsi_2015	4.097e-88	302.0	COG0008@1|root,COG0008@2|Bacteria,2GF80@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS3_k127_1047224_2	83406.HDN1F_27750	1.318e-15	79.0	COG0661@1|root,COG0661@2|Bacteria,1N1UJ@1224|Proteobacteria,1RP1G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	unusual protein kinase	aarF	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
TLS3_k127_1047224_0	882083.SacmaDRAFT_1972	1.693e-87	321.0	COG0553@1|root,COG0553@2|Bacteria,2GM2V@201174|Actinobacteria,4DXMJ@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM helicase	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	DUF3883,Helicase_C,SNF2_N
TLS3_k127_1047224_1	765913.ThidrDRAFT_4330	6.898e-42	175.0	COG0823@1|root,COG1572@1|root,COG4870@1|root,COG0823@2|Bacteria,COG1572@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,LRR_5,Peptidase_C1,SLH
TLS3_k127_1047224_3	1347086.CCBA010000010_gene1800	0.0001515	55.0	COG3227@1|root,COG4733@1|root,COG5184@1|root,COG3227@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,1UZD4@1239|Firmicutes,4HD48@91061|Bacilli,1ZESI@1386|Bacillus	91061|Bacilli	DZ	COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	RCC1_2
TLS3_k127_1049324_0	929703.KE386491_gene2448	4.187e-90	309.0	COG2907@1|root,COG2907@2|Bacteria,4NKSM@976|Bacteroidetes	976|Bacteroidetes	S	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS3_k127_1050384_0	398767.Glov_3184	1.239e-32	143.0	COG1538@1|root,COG1538@2|Bacteria,1QWWG@1224|Proteobacteria,42PD6@68525|delta/epsilon subdivisions,2WK6G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS3_k127_1050384_2	349163.Acry_0221	0.0001774	52.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2UAPV@28211|Alphaproteobacteria,2JSSQ@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
TLS3_k127_1050384_1	483219.LILAB_25690	1.524e-26	110.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2YU09@29|Myxococcales	28221|Deltaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261	ATP-grasp_2,Ligase_CoA
TLS3_k127_1059164_2	880073.Calab_0100	1.082e-13	80.0	COG0123@1|root,COG0123@2|Bacteria,2NRDM@2323|unclassified Bacteria	2|Bacteria	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS3_k127_1059164_0	929562.Emtol_2179	4.754e-53	196.0	COG0106@1|root,COG0106@2|Bacteria,4NEEX@976|Bacteroidetes,47M7D@768503|Cytophagia	976|Bacteroidetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS3_k127_1059164_1	1163671.JAGI01000001_gene278	6.36e-49	182.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,36I01@31979|Clostridiaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS3_k127_1060252_0	1444712.BN1013_01622	2.11e-103	349.0	COG1252@1|root,COG1252@2|Bacteria,2JFCT@204428|Chlamydiae	204428|Chlamydiae	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS3_k127_1074780_0	580332.Slit_1460	3.255e-87	295.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,44W78@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS,PAS_9,dCache_2
TLS3_k127_1085864_0	1123278.KB893543_gene5480	1.117e-26	121.0	COG0584@1|root,COG0584@2|Bacteria,4NJ13@976|Bacteroidetes,47MVH@768503|Cytophagia	976|Bacteroidetes	C	Glycerophosphoryl diester phosphodiesterase family	-	-	-	-	-	-	-	-	-	-	-	-	GDPD
TLS3_k127_1100168_1	153721.MYP_4382	3.039e-12	75.0	COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,47JN3@768503|Cytophagia	976|Bacteroidetes	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
TLS3_k127_1100168_0	644282.Deba_3251	8.216e-95	332.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2WJE6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_1100777_0	1242864.D187_003297	5.554e-42	168.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,43BXM@68525|delta/epsilon subdivisions	1224|Proteobacteria	V	Peptidase C39 family	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
TLS3_k127_1106722_1	1278073.MYSTI_00676	3.582e-75	260.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42P3K@68525|delta/epsilon subdivisions,2WMB8@28221|Deltaproteobacteria,2YWYR@29|Myxococcales	28221|Deltaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS3_k127_1106722_0	305900.GV64_10185	1.129e-88	302.0	COG0491@1|root,COG0491@2|Bacteria,1MWVM@1224|Proteobacteria	1224|Proteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1108713_1	1123388.AQWU01000050_gene572	7.98e-19	99.0	COG4447@1|root,COG4447@2|Bacteria,1WJIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1108713_0	1122135.KB893157_gene231	1.211e-147	481.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_1109810_1	401053.AciPR4_2516	2.237e-07	62.0	COG3292@1|root,COG3292@2|Bacteria,3Y6IF@57723|Acidobacteria,2JKIB@204432|Acidobacteriia	204432|Acidobacteriia	T	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
TLS3_k127_1109810_0	1499967.BAYZ01000028_gene1280	9.124e-17	82.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
TLS3_k127_1121215_1	357808.RoseRS_2967	1.578e-05	53.0	COG2723@1|root,COG2723@2|Bacteria,2G5QE@200795|Chloroflexi,3774T@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS3_k127_1121215_0	1121935.AQXX01000092_gene3385	7.673e-80	273.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria,1XIV8@135619|Oceanospirillales	135619|Oceanospirillales	F	dihydroorotase	-	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS3_k127_1123738_1	1385514.N782_19995	5.323e-06	51.0	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,2YATR@289201|Pontibacillus	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
TLS3_k127_1123738_0	1408422.JHYF01000011_gene3390	2.564e-57	207.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,36G6I@31979|Clostridiaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS3_k127_1125195_0	1538295.JY96_14105	3.12e-75	270.0	COG0477@1|root,COG2814@2|Bacteria,1MU9G@1224|Proteobacteria,2VITW@28216|Betaproteobacteria,1KMQ7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	sotB	-	-	ko:K08159,ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2.15,2.A.1.2.18,2.A.1.2.65	-	-	MFS_1
TLS3_k127_1125195_1	1333998.M2A_1340	3.111e-22	102.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,4BPEK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS3_k127_1157161_1	871963.Desdi_3219	5.069e-06	60.0	COG2247@1|root,COG2247@2|Bacteria,1UZS5@1239|Firmicutes,24FE6@186801|Clostridia,2600Z@186807|Peptococcaceae	186801|Clostridia	M	cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Endopep_inhib,fn3
TLS3_k127_1157161_0	862908.BMS_2857	2.013e-102	349.0	COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,43E4Q@68525|delta/epsilon subdivisions,2MTP3@213481|Bdellovibrionales,2X7E4@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	CO dehydrogenase flavoprotein C-terminal domain	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
TLS3_k127_1178994_0	525904.Tter_1249	4.814e-99	330.0	COG0133@1|root,COG0133@2|Bacteria,2NNWF@2323|unclassified Bacteria	2|Bacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_1178994_1	362418.IW19_23165	1.726e-05	51.0	2ERAY@1|root,33IWM@2|Bacteria,4NZ99@976|Bacteroidetes,1IKXI@117743|Flavobacteriia,2NXHM@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1183504_0	1265505.ATUG01000001_gene3978	3.16e-10	70.0	COG2203@1|root,COG2203@2|Bacteria,1NT6X@1224|Proteobacteria,42XRB@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
TLS3_k127_1185751_5	1569209.BBPH01000137_gene2448	4.435e-09	63.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2TQNX@28211|Alphaproteobacteria,2PUHZ@265|Paracoccus	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
TLS3_k127_1185751_4	1417230.AYOT01000146_gene1623	4.025e-11	69.0	COG3951@1|root,COG3951@2|Bacteria	2|Bacteria	MNO	Flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02035	-	GH23	-	Rod-binding
TLS3_k127_1185751_7	436114.SYO3AOP1_1429	0.0001462	53.0	COG0457@1|root,COG0793@1|root,COG0457@2|Bacteria,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,TPR_8,Tricorn_C1
TLS3_k127_1185751_6	1500306.JQLA01000004_gene5320	1.842e-07	62.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TT48@28211|Alphaproteobacteria,4B9PU@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_1185751_3	1206730.BAGA01000185_gene3628	3.061e-13	80.0	COG1173@1|root,COG1173@2|Bacteria,2HFNM@201174|Actinobacteria,4FVB8@85025|Nocardiaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_1185751_1	498211.CJA_1172	4.052e-73	250.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S24N@1236|Gammaproteobacteria,1FGTA@10|Cellvibrio	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
TLS3_k127_1185751_0	1121930.AQXG01000001_gene1487	7.699e-123	403.0	COG0274@1|root,COG0274@2|Bacteria,4NGE3@976|Bacteroidetes	976|Bacteroidetes	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS3_k127_1185751_2	638302.HMPREF0908_1439	1.051e-38	158.0	COG3494@1|root,COG3494@2|Bacteria,1U1G6@1239|Firmicutes,4H2CZ@909932|Negativicutes	909932|Negativicutes	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
TLS3_k127_1189516_1	1048983.EL17_17470	1.797e-30	136.0	COG0784@1|root,COG2203@1|root,COG4251@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,4PKQT@976|Bacteroidetes,47XZ7@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
TLS3_k127_1189516_0	96561.Dole_2614	1.189e-48	183.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria,2MK34@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS3_k127_1191932_0	1122243.KB903773_gene1330	4.756e-48	190.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1S0TD@1236|Gammaproteobacteria,3NQZR@468|Moraxellaceae	1236|Gammaproteobacteria	T	Hpt domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Hpt
TLS3_k127_1193703_0	243275.TDE_0295	2.592e-47	179.0	COG0188@1|root,COG0188@2|Bacteria,2J5NK@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS3_k127_1193703_1	1392838.AWNM01000076_gene2486	2.739e-10	66.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2VKF6@28216|Betaproteobacteria,3T35I@506|Alcaligenaceae	28216|Betaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS3_k127_1195173_1	335543.Sfum_1614	9.154e-90	310.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2MR3A@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VWA containing CoxE family protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_1195173_0	335543.Sfum_1615	1.224e-95	321.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2MRC6@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS3_k127_1195173_2	1357275.AVEL02000011_gene3814	9.791e-05	50.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,1RRV4@1236|Gammaproteobacteria,1Z5FQ@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
TLS3_k127_1195953_1	1121403.AUCV01000005_gene315	1.281e-16	92.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS3_k127_1195953_0	945713.IALB_2106	4.824e-18	86.0	COG1862@1|root,COG1862@2|Bacteria	2|Bacteria	U	protein transport	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS3_k127_1201577_1	1313421.JHBV01000014_gene3931	7.694e-05	53.0	COG3291@1|root,COG3291@2|Bacteria,4NJ39@976|Bacteroidetes	976|Bacteroidetes	C	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	BNR_assoc_N,Beta_helix,DUF4465
TLS3_k127_1201577_0	83406.HDN1F_08090	3.022e-13	80.0	COG4206@1|root,COG4206@2|Bacteria,1PE2W@1224|Proteobacteria,1S5SY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	TonB dependent receptor	btuB	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS3_k127_1218537_1	28258.KP05_11905	5.587e-40	151.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1XK6F@135619|Oceanospirillales	135619|Oceanospirillales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS3_k127_1218537_0	1279017.AQYJ01000019_gene1463	1.34e-63	224.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,466EY@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS3_k127_1218537_2	203122.Sde_0973	1.864e-21	94.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,46724@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS3_k127_1225238_1	1120925.F941_01333	2.925e-23	105.0	COG3832@1|root,COG3832@2|Bacteria,1QC9B@1224|Proteobacteria,1SSVV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_1225238_0	1123371.ATXH01000003_gene1895	5.157e-101	335.0	COG0653@1|root,COG0653@2|Bacteria,2GGR1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS3_k127_1234380_0	443254.Marpi_1426	4.755e-20	98.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	DHODB_Fe-S_bind,Fer4_22,HATPase_c,HisKA,NAD_binding_1,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_1234380_1	224911.27350430	6.687e-10	70.0	COG2202@1|root,COG3437@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JR0R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_1236783_0	1242864.D187_003360	1.629e-13	81.0	COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,43824@68525|delta/epsilon subdivisions,2X3C7@28221|Deltaproteobacteria,2YVD2@29|Myxococcales	28221|Deltaproteobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
TLS3_k127_1248821_0	1144275.COCOR_01311	1.666e-14	86.0	28PTA@1|root,2ZCEK@2|Bacteria,1RCNT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1262961_0	1122201.AUAZ01000002_gene1007	1.883e-160	509.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,464AI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	prpF	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0071704,GO:0072329,GO:1901575	-	ko:K09788	ko00640,map00640	-	R11264	RC03405	ko00000,ko00001,ko01000	-	-	-	PrpF
TLS3_k127_1262961_2	1144343.PMI41_04047	2.254e-20	95.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,43KNC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	sdpR	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_1262961_1	595537.Varpa_2260	5.303e-23	103.0	COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2VVCX@28216|Betaproteobacteria,4AFCW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_1266403_1	469383.Cwoe_5895	8.978e-07	54.0	COG1266@1|root,COG1266@2|Bacteria,2HRHJ@201174|Actinobacteria,4CTHE@84995|Rubrobacteria	84995|Rubrobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS3_k127_1266403_0	1267534.KB906754_gene3807	5.068e-33	138.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	7TMR-DISM_7TM,HAMP,Peripla_BP_3,SpoIIE
TLS3_k127_1274901_0	1045858.Bint_0522	2.578e-23	104.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_1274901_1	314225.ELI_13240	6.41e-11	72.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,2K22Y@204457|Sphingomonadales	204457|Sphingomonadales	D	Membrane-bound metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_1275670_0	760192.Halhy_6180	1.261e-160	512.0	COG1902@1|root,COG1902@2|Bacteria,4NF98@976|Bacteroidetes,1IQ6Y@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
TLS3_k127_1275670_1	1121957.ATVL01000012_gene679	1.732e-47	180.0	28PB4@1|root,2ZC42@2|Bacteria,4NJ4V@976|Bacteroidetes,47QQM@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1275670_3	1121957.ATVL01000012_gene680	3.425e-28	119.0	2DNUQ@1|root,32Z94@2|Bacteria,4NVH0@976|Bacteroidetes,47QAG@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4281)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4281
TLS3_k127_1275670_2	1041522.MCOL_V206545	6.051e-30	123.0	COG1309@1|root,COG1309@2|Bacteria,2IMN5@201174|Actinobacteria,2391H@1762|Mycobacteriaceae	201174|Actinobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS3_k127_1276189_0	644966.Tmar_0390	2.032e-84	286.0	COG1028@1|root,COG1028@2|Bacteria,1TQZW@1239|Firmicutes,249T4@186801|Clostridia	186801|Clostridia	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_1277692_0	1125863.JAFN01000001_gene1138	5.97e-109	364.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,42MR9@68525|delta/epsilon subdivisions,2WIP3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
TLS3_k127_1286054_0	1173263.Syn7502_00491	1.071e-16	84.0	COG0164@1|root,COG0164@2|Bacteria,1G507@1117|Cyanobacteria,1H0B0@1129|Synechococcus	1117|Cyanobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS3_k127_1286054_1	1123401.JHYQ01000028_gene3178	6.221e-05	53.0	COG4461@1|root,COG4461@2|Bacteria,1NGDW@1224|Proteobacteria,1SH6B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	LprI
TLS3_k127_1291931_0	1237149.C900_04059	2.011e-54	196.0	COG4539@1|root,COG4539@2|Bacteria,4NQIX@976|Bacteroidetes,47Q6B@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
TLS3_k127_1298897_0	126957.SMAR004638-PA	9.936e-44	181.0	COG0666@1|root,KOG4369@1|root,KOG0504@2759|Eukaryota,KOG4369@2759|Eukaryota,38I05@33154|Opisthokonta,3BHRH@33208|Metazoa,3CU4I@33213|Bilateria,41XRM@6656|Arthropoda	33208|Metazoa	T	domain-containing protein	ANKRD17	GO:0000785,GO:0001568,GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0001817,GO:0001819,GO:0001944,GO:0001955,GO:0002376,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002831,GO:0002833,GO:0003674,GO:0003682,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005694,GO:0005737,GO:0006275,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007005,GO:0007010,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007346,GO:0007399,GO:0007423,GO:0007492,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009987,GO:0010506,GO:0010507,GO:0010556,GO:0010564,GO:0010639,GO:0010646,GO:0010647,GO:0010821,GO:0010823,GO:0010927,GO:0010941,GO:0012505,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019730,GO:0019899,GO:0019900,GO:0019901,GO:0021700,GO:0022008,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030182,GO:0030239,GO:0031032,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031329,GO:0031330,GO:0031347,GO:0031349,GO:0031430,GO:0031672,GO:0031674,GO:0031965,GO:0031967,GO:0031975,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0032989,GO:0033043,GO:0039531,GO:0039533,GO:0039535,GO:0040011,GO:0042692,GO:0042742,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043122,GO:0043123,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043292,GO:0043900,GO:0043902,GO:0044085,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0045087,GO:0045088,GO:0045089,GO:0045214,GO:0045595,GO:0045596,GO:0045787,GO:0045931,GO:0046530,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048592,GO:0048646,GO:0048699,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0050688,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051052,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051147,GO:0051148,GO:0051150,GO:0051151,GO:0051171,GO:0051239,GO:0051240,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0055001,GO:0055002,GO:0060255,GO:0060361,GO:0060548,GO:0061061,GO:0065007,GO:0070925,GO:0071695,GO:0071840,GO:0072358,GO:0072359,GO:0080090,GO:0080134,GO:0090068,GO:0090596,GO:0097435,GO:0098542,GO:0099080,GO:0099081,GO:0099512,GO:1900087,GO:1900245,GO:1900246,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902531,GO:1902533,GO:1902806,GO:1902808,GO:1903146,GO:1903147,GO:2000045,GO:2000112	-	ko:K16726	-	-	-	-	ko00000,ko03036	-	-	-	Ank_2,Ank_4,KH_1
TLS3_k127_1299028_0	1229172.JQFA01000002_gene3548	1.876e-58	209.0	COG0235@1|root,COG0235@2|Bacteria,1G59N@1117|Cyanobacteria,1HANS@1150|Oscillatoriales	1117|Cyanobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
TLS3_k127_1299028_1	45285.XP_003645550.1	4.173e-34	145.0	COG0331@1|root,2QQJX@2759|Eukaryota,38EJX@33154|Opisthokonta,3NV76@4751|Fungi,3QMNX@4890|Ascomycota,3RR7M@4891|Saccharomycetes,3RZ61@4893|Saccharomycetaceae	4751|Fungi	I	to Saccharomyces cerevisiae FAS1 (YKL182W)	FAS1	GO:0001676,GO:0003674,GO:0003824,GO:0004312,GO:0004313,GO:0004314,GO:0004317,GO:0004318,GO:0004319,GO:0004321,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016409,GO:0016417,GO:0016418,GO:0016419,GO:0016420,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0072330,GO:1901576	2.3.1.86	ko:K00667,ko:K00668	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R01404,R01624,R01626,R04355,R04428,R04430,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04725,R04726,R04952,R04953,R04954,R04956,R04957,R04959,R04960,R04962,R04963,R04964,R04965,R04967,R04968,R04970,R10700	RC00004,RC00029,RC00039,RC00052,RC00076,RC00117,RC00120,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACPS,Acyl_transf_1,DUF1729,Ketoacyl-synt_C,MaoC_dehydrat_N,MaoC_dehydratas,SAT,adh_short,ketoacyl-synt
TLS3_k127_1300475_1	1121930.AQXG01000011_gene1727	6.966e-15	80.0	COG2172@1|root,COG2172@2|Bacteria,4NV3J@976|Bacteroidetes	976|Bacteroidetes	T	Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS3_k127_1300475_0	386456.JQKN01000007_gene3315	2.712e-48	180.0	COG2208@1|root,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota,23PHZ@183925|Methanobacteria	183925|Methanobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,SpoIIE
TLS3_k127_1303519_1	1254432.SCE1572_26700	1.668e-18	94.0	COG3396@1|root,COG3396@2|Bacteria,1Q169@1224|Proteobacteria,4374A@68525|delta/epsilon subdivisions,2X3NW@28221|Deltaproteobacteria,2YWPZ@29|Myxococcales	28221|Deltaproteobacteria	S	Phenylacetate-CoA oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1303519_2	1451261.AS96_03455	1.346e-15	88.0	COG3458@1|root,COG3458@2|Bacteria,2GNHH@201174|Actinobacteria,4FMNK@85023|Microbacteriaceae	201174|Actinobacteria	Q	Acetyl xylan esterase (AXE1)	-	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
TLS3_k127_1303519_3	305700.B447_07522	1.269e-05	52.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,2VUVV@28216|Betaproteobacteria,2KWJI@206389|Rhodocyclales	206389|Rhodocyclales	H	dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
TLS3_k127_1303519_0	1385517.N800_04505	3.066e-43	162.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1X3UX@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS3_k127_1310297_1	1480694.DC28_09930	4.059e-26	117.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_1310297_0	485918.Cpin_1068	5.333e-132	426.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1INXI@117747|Sphingobacteriia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
TLS3_k127_1311480_2	926550.CLDAP_36000	9.496e-14	72.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi	200795|Chloroflexi	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TLS3_k127_1311480_1	575589.HMPREF0018_02558	1.427e-59	218.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,3NJ42@468|Moraxellaceae	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
TLS3_k127_1311480_0	234267.Acid_4232	4.104e-116	391.0	COG1138@1|root,COG1138@2|Bacteria,3Y40N@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS3_k127_1311627_3	1121935.AQXX01000113_gene1439	1.075e-41	162.0	28JIP@1|root,2Z82C@2|Bacteria,1R5N9@1224|Proteobacteria,1RY8I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	s1 p1 nuclease	-	-	3.1.30.1	ko:K05986	-	-	-	-	ko00000,ko01000	-	-	-	S1-P1_nuclease
TLS3_k127_1311627_2	1121957.ATVL01000010_gene485	1.282e-85	296.0	COG2603@1|root,COG2603@2|Bacteria,4NH7W@976|Bacteroidetes,47KFW@768503|Cytophagia	976|Bacteroidetes	S	Rhodanese Homology Domain	-	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
TLS3_k127_1311627_0	1123054.KB907711_gene369	4.093e-112	372.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1WYEY@135613|Chromatiales	135613|Chromatiales	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
TLS3_k127_1311627_1	933262.AXAM01000099_gene212	9.618e-89	304.0	COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,42ZPX@68525|delta/epsilon subdivisions,2WV2B@28221|Deltaproteobacteria,2MND9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
TLS3_k127_1313431_0	1121438.JNJA01000020_gene2747	8.023e-95	324.0	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,42Y97@68525|delta/epsilon subdivisions,2WTJS@28221|Deltaproteobacteria,2MAZV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,dCache_1
TLS3_k127_1321830_0	246194.CHY_0845	1.038e-133	439.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42I0M@68295|Thermoanaerobacterales	186801|Clostridia	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS3_k127_1321830_4	237368.SCABRO_02185	1.802e-19	94.0	COG4642@1|root,COG4642@2|Bacteria	2|Bacteria	S	regulation of ryanodine-sensitive calcium-release channel activity	-	-	-	-	-	-	-	-	-	-	-	-	MORN
TLS3_k127_1321830_3	1279009.ADICEAN_01811	2.146e-26	109.0	COG2824@1|root,COG2824@2|Bacteria,4NEFZ@976|Bacteroidetes,47S53@768503|Cytophagia	976|Bacteroidetes	P	PhnA domain	phnA	-	-	ko:K06193	ko01120,map01120	-	-	-	ko00000	-	-	-	PhnA,PhnA_Zn_Ribbon
TLS3_k127_1321830_2	926560.KE387027_gene493	2.057e-32	135.0	2EVIQ@1|root,33NYW@2|Bacteria	2|Bacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
TLS3_k127_1321830_1	68219.JNXI01000017_gene7279	3.114e-133	430.0	COG1090@1|root,COG1090@2|Bacteria,2GU34@201174|Actinobacteria	201174|Actinobacteria	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS3_k127_1321830_5	425104.Ssed_2796	2.108e-17	92.0	COG3637@1|root,COG4625@1|root,COG3637@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1T3XP@1236|Gammaproteobacteria,2QEUQ@267890|Shewanellaceae	1236|Gammaproteobacteria	M	outer membrane autotransporter barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
TLS3_k127_1326663_2	744872.Spica_0333	9.851e-22	102.0	COG1595@1|root,COG1595@2|Bacteria,2J7DE@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_1326663_3	545694.TREPR_3425	1.089e-13	76.0	2AN0C@1|root,31CXK@2|Bacteria,2J95I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1326663_0	1134413.ANNK01000116_gene1957	4.882e-51	190.0	COG2107@1|root,COG2107@2|Bacteria,1U8UK@1239|Firmicutes,4HBE2@91061|Bacilli,1ZEEB@1386|Bacillus	91061|Bacilli	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS3_k127_1326663_1	596328.HMPREF0578_2288	2.228e-42	161.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4D38P@85005|Actinomycetales	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS3_k127_1333857_3	264462.Bd1768	8.313e-38	152.0	COG0767@1|root,COG0767@2|Bacteria,1N2HV@1224|Proteobacteria,42UV1@68525|delta/epsilon subdivisions,2WQXM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS3_k127_1333857_0	1192034.CAP_5186	2.363e-90	306.0	COG0491@1|root,COG0491@2|Bacteria,1N1ZW@1224|Proteobacteria,42WXX@68525|delta/epsilon subdivisions,2WSQH@28221|Deltaproteobacteria,2YZ1U@29|Myxococcales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_1333857_4	666681.M301_2309	6.083e-32	143.0	COG2203@1|root,COG3447@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KNQY@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
TLS3_k127_1333857_2	1121440.AUMA01000005_gene2609	1.926e-42	176.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR,Response_reg,dCache_1
TLS3_k127_1333857_1	1191523.MROS_1343	6.599e-81	278.0	COG1045@1|root,COG1045@2|Bacteria	2|Bacteria	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS3_k127_1338335_0	483219.LILAB_04785	1.539e-74	260.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1NI1E@1224|Proteobacteria,430IZ@68525|delta/epsilon subdivisions,2WW3C@28221|Deltaproteobacteria,2YYH1@29|Myxococcales	28221|Deltaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_M10
TLS3_k127_1343772_0	1297865.APJD01000007_gene2139	3.872e-64	233.0	COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,3JQNR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_1346953_0	880073.Calab_0069	3.282e-165	528.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	acdA	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_1347979_0	1307761.L21SP2_0317	2.104e-12	79.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1349439_0	997346.HMPREF9374_2869	9.223e-82	279.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,27B7R@186824|Thermoactinomycetaceae	91061|Bacilli	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS3_k127_1349439_2	980584.AFPB01000176_gene1787	8.722e-41	164.0	2DNS3@1|root,32YW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1349439_1	748280.NH8B_0112	3.66e-50	184.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
TLS3_k127_135405_1	1304885.AUEY01000002_gene329	3.23e-05	51.0	2BV42@1|root,32QH6@2|Bacteria,1MZ0Q@1224|Proteobacteria,42T0A@68525|delta/epsilon subdivisions,2WP4M@28221|Deltaproteobacteria,2MN8V@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_135405_0	179408.Osc7112_1555	1.501e-79	273.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG2770@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
TLS3_k127_1356037_1	1340434.AXVA01000035_gene106	2.961e-15	77.0	COG5522@1|root,COG5522@2|Bacteria,1V4XE@1239|Firmicutes,4HHC6@91061|Bacilli,1ZBDN@1386|Bacillus	91061|Bacilli	S	Integral membrane protein	ywaF	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
TLS3_k127_1356037_0	526224.Bmur_1792	1.994e-103	345.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS3_k127_1376577_4	583355.Caka_1928	3.788e-41	157.0	COG0189@1|root,COG0586@1|root,COG1073@1|root,COG0189@2|Bacteria,COG0586@2|Bacteria,COG1073@2|Bacteria,46UXZ@74201|Verrucomicrobia	74201|Verrucomicrobia	HJ	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_1376577_1	504472.Slin_2494	9.402e-60	216.0	COG1073@1|root,COG1073@2|Bacteria,4NNXQ@976|Bacteroidetes,47PV9@768503|Cytophagia	976|Bacteroidetes	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_1376577_0	313606.M23134_06670	4.364e-77	274.0	COG2114@1|root,COG2114@2|Bacteria,4NEVN@976|Bacteroidetes,47MR3@768503|Cytophagia	976|Bacteroidetes	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_12,TPR_8
TLS3_k127_1376577_5	886377.Murru_3394	2.076e-30	126.0	2C87P@1|root,32H7J@2|Bacteria,4NS7S@976|Bacteroidetes,1I3A8@117743|Flavobacteriia	976|Bacteroidetes	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
TLS3_k127_1376577_3	1166018.FAES_0862	2.459e-43	164.0	COG0607@1|root,COG0607@2|Bacteria,4NQ61@976|Bacteroidetes,47Q3A@768503|Cytophagia	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_1376577_9	491205.JARQ01000006_gene2697	3.514e-13	77.0	COG1595@1|root,COG1595@2|Bacteria,4NHNI@976|Bacteroidetes,1HY4K@117743|Flavobacteriia,3ZTI5@59732|Chryseobacterium	976|Bacteroidetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_1376577_10	1101195.Meth11DRAFT_2246	4.522e-05	49.0	COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria,2W81G@28216|Betaproteobacteria,2KNB0@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS3_k127_1376577_7	1128398.Curi_c07320	2.937e-18	87.0	COG0695@1|root,COG0695@2|Bacteria,1VK60@1239|Firmicutes	1239|Firmicutes	O	Glutaredoxin	nrdH	-	-	ko:K03676,ko:K06191	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
TLS3_k127_1376577_2	665571.STHERM_c12100	4.732e-45	181.0	COG2114@1|root,COG5002@1|root,COG2114@2|Bacteria,COG5002@2|Bacteria,2J6ME@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_1376577_8	1280950.HJO_07852	3.498e-15	79.0	COG0640@1|root,COG0640@2|Bacteria,1RIJ9@1224|Proteobacteria,2UVS4@28211|Alphaproteobacteria,4411C@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_1381061_2	215803.DB30_5134	1.638e-35	139.0	COG3795@1|root,COG3795@2|Bacteria,1RKYW@1224|Proteobacteria,43DU4@68525|delta/epsilon subdivisions,2WYVK@28221|Deltaproteobacteria,2Z0QY@29|Myxococcales	28221|Deltaproteobacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
TLS3_k127_1381061_1	1131812.JQMS01000001_gene103	7.14e-39	155.0	COG2764@1|root,COG2764@2|Bacteria,4NQD7@976|Bacteroidetes,1I2AQ@117743|Flavobacteriia,2NW94@237|Flavobacterium	976|Bacteroidetes	S	Glyoxalase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
TLS3_k127_1381061_0	1122927.KB895412_gene807	9.146e-63	221.0	COG0596@1|root,COG0596@2|Bacteria,1TTAE@1239|Firmicutes,4HF74@91061|Bacilli,26WWK@186822|Paenibacillaceae	91061|Bacilli	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_1387061_4	1089548.KI783301_gene188	5.222e-05	55.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TQ94@1239|Firmicutes,4HAK1@91061|Bacilli,3WFQ0@539002|Bacillales incertae sedis	91061|Bacilli	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL
TLS3_k127_1387061_2	771875.Ferpe_0331	7.128e-10	71.0	COG2208@1|root,COG2208@2|Bacteria,2GCU2@200918|Thermotogae	200918|Thermotogae	KT	Stage II sporulation	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
TLS3_k127_1387061_3	1040986.ATYO01000005_gene6230	1.228e-07	62.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,43HBN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	lpxH	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
TLS3_k127_1387061_1	264732.Moth_1133	3.194e-55	209.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,42FW0@68295|Thermoanaerobacterales	186801|Clostridia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_1387061_0	768706.Desor_5491	7.5e-98	329.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS3_k127_1389102_0	1121440.AUMA01000011_gene2448	6.619e-13	80.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M2X@68525|delta/epsilon subdivisions,2WJMY@28221|Deltaproteobacteria,2M8ZP@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_1389102_1	28042.GU90_17890	2.074e-11	72.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4E45R@85010|Pseudonocardiales	201174|Actinobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TLS3_k127_1389102_2	5147.XP_003352341.1	3.974e-05	51.0	2CNJ8@1|root,2QWPG@2759|Eukaryota,38G68@33154|Opisthokonta,3NY0A@4751|Fungi,3QNNQ@4890|Ascomycota,21PB1@147550|Sordariomycetes,3UERY@5139|Sordariales,3UIYZ@5148|Sordariaceae	4751|Fungi	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_1391803_0	215803.DB30_6597	1.144e-30	139.0	COG4223@1|root,COG4223@2|Bacteria,1NDYH@1224|Proteobacteria,433KY@68525|delta/epsilon subdivisions,2WXPE@28221|Deltaproteobacteria,2YZMD@29|Myxococcales	28221|Deltaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1391958_0	1122599.AUGR01000010_gene981	3.995e-16	83.0	28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,1RP8T@1236|Gammaproteobacteria,1XIH6@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1391958_1	1502850.FG91_00795	1.785e-12	70.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria,2KEB5@204457|Sphingomonadales	204457|Sphingomonadales	QU	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3,PD40
TLS3_k127_1397348_1	740709.A10D4_02342	4.968e-05	51.0	2DMIH@1|root,32RT1@2|Bacteria,1RDKU@1224|Proteobacteria,1S562@1236|Gammaproteobacteria,2QG7Z@267893|Idiomarinaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1397348_0	1379858.N508_01013	8.889e-14	72.0	COG0231@1|root,COG0231@2|Bacteria,2GEJZ@200930|Deferribacteres	200930|Deferribacteres	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS3_k127_1400834_0	1158292.JPOE01000002_gene1854	9.325e-211	668.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
TLS3_k127_1400834_1	1380387.JADM01000012_gene1567	5.63e-43	160.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S8W1@1236|Gammaproteobacteria,1XKRT@135619|Oceanospirillales	135619|Oceanospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_1406189_0	216595.PFLU_1903	3.679e-196	619.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RQ8R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS3_k127_1413385_1	246197.MXAN_1016	3.386e-08	61.0	COG2863@1|root,COG2863@2|Bacteria,1RKUY@1224|Proteobacteria,43BWX@68525|delta/epsilon subdivisions,2X77P@28221|Deltaproteobacteria,2Z1IB@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS3_k127_1413385_0	880073.Calab_0644	6.683e-63	224.0	COG0738@1|root,COG0738@2|Bacteria,2NQUK@2323|unclassified Bacteria	2|Bacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_1432068_2	1137799.GZ78_24825	1.27e-12	77.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DA1-like,Guanylate_cyc,HAMP,LIM
TLS3_k127_1432068_1	269799.Gmet_1099	2.243e-125	411.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,43T2M@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
TLS3_k127_1432068_0	521045.Kole_1174	3.23e-156	509.0	COG0366@1|root,COG0366@2|Bacteria,2GCN1@200918|Thermotogae	200918|Thermotogae	G	SMART alpha amylase catalytic sub domain	-	-	3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Malt_amylase_C
TLS3_k127_1433059_0	856793.MICA_2009	6.37e-166	533.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,4BRGB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
TLS3_k127_1433059_1	759914.BP951000_1053	4.749e-36	142.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_1436736_0	688269.Theth_1336	1.807e-40	153.0	COG0251@1|root,COG0251@2|Bacteria,2GDBF@200918|Thermotogae	200918|Thermotogae	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS3_k127_1436736_2	1437824.BN940_11636	3.267e-05	55.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJA5@28216|Betaproteobacteria	28216|Betaproteobacteria	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406,ko:K05874	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,NIT
TLS3_k127_145788_0	96561.Dole_1081	9.991e-121	402.0	COG2199@1|root,COG3706@2|Bacteria,1N9PI@1224|Proteobacteria,42MQF@68525|delta/epsilon subdivisions,2WIUE@28221|Deltaproteobacteria,2MJ68@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
TLS3_k127_145914_3	886293.Sinac_1870	9.839e-06	48.0	COG0640@1|root,COG0640@2|Bacteria,2IZUJ@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
TLS3_k127_145914_1	1198452.Jab_2c01640	9.331e-103	350.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2WEEZ@28216|Betaproteobacteria,473TA@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
TLS3_k127_145914_0	926569.ANT_03440	3.345e-115	385.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2G825@200795|Chloroflexi	200795|Chloroflexi	CO	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_145914_2	153721.MYP_3548	8.136e-34	145.0	COG3858@1|root,COG3858@2|Bacteria,4NJZ6@976|Bacteroidetes,47QYP@768503|Cytophagia	976|Bacteroidetes	S	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	BNR_assoc_N,Glyco_hydro_18,Laminin_G_3
TLS3_k127_1459309_0	1270193.JARP01000001_gene2235	6.325e-167	533.0	COG2267@1|root,COG2267@2|Bacteria,4NFIJ@976|Bacteroidetes,1IJDM@117743|Flavobacteriia,2NSHF@237|Flavobacterium	976|Bacteroidetes	I	Releases the N-terminal proline from various substrates	fpaP	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS3_k127_1459309_3	1307761.L21SP2_2570	3.686e-26	119.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
TLS3_k127_1459309_2	1307761.L21SP2_2569	4.792e-32	141.0	COG1116@1|root,COG1116@2|Bacteria	2|Bacteria	P	anion transmembrane transporter activity	MA20_26685	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS3_k127_1459309_4	1177154.Y5S_03767	1.025e-05	51.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1XKJR@135619|Oceanospirillales	135619|Oceanospirillales	P	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
TLS3_k127_1459309_1	1536769.P40081_25110	2.67e-90	314.0	COG4335@1|root,COG4335@2|Bacteria,1TRE4@1239|Firmicutes,4HA0G@91061|Bacilli,26RB3@186822|Paenibacillaceae	91061|Bacilli	L	DNA alkylation repair	yhaZ	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS3_k127_145984_1	1262914.BN533_00286	5.588e-13	74.0	COG0848@1|root,COG0848@2|Bacteria,1V5RQ@1239|Firmicutes,4H4XU@909932|Negativicutes	909932|Negativicutes	U	Transport energizing protein, ExbD TolR family	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
TLS3_k127_145984_0	1122173.AXVL01000015_gene112	3.941e-15	78.0	COG0811@1|root,COG0811@2|Bacteria,379FS@32066|Fusobacteria	32066|Fusobacteria	U	Transporter, MotA TolQ ExbB proton channel family protein	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TLS3_k127_1461663_0	394503.Ccel_1545	5.29e-62	235.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
TLS3_k127_1461830_1	1120983.KB894570_gene1556	3.385e-20	94.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,1JN9S@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Carboxyl transferase domain	-	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_1461830_0	153721.MYP_1818	1.177e-168	540.0	COG3158@1|root,COG3158@2|Bacteria,4NET9@976|Bacteroidetes,47K58@768503|Cytophagia	976|Bacteroidetes	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TLS3_k127_1482243_1	83406.HDN1F_08830	1.915e-94	329.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Alginate_lyase2,Cellulase,Chondroitinas_B,F5_F8_type_C,Glyco_hydro_16
TLS3_k127_1482243_3	305900.GV64_04005	5.543e-14	85.0	COG2355@1|root,COG2355@2|Bacteria,1MXA0@1224|Proteobacteria,1RMJQ@1236|Gammaproteobacteria,1XHQY@135619|Oceanospirillales	135619|Oceanospirillales	E	COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
TLS3_k127_1482243_0	1242864.D187_008126	3.35e-268	837.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	AAG	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Alginate_lyase,Cellulase,DUF1929,Pectate_lyase_3,RicinB_lectin_2
TLS3_k127_1482243_2	383372.Rcas_3626	1.482e-17	95.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS3_k127_1487209_1	179408.Osc7112_5529	4.691e-32	143.0	COG2931@1|root,COG2931@2|Bacteria,1G2XZ@1117|Cyanobacteria,1HEEK@1150|Oscillatoriales	1117|Cyanobacteria	Q	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,DUF4347,FG-GAP_2,VCBS
TLS3_k127_1487209_2	68170.KL590490_gene1267	4.487e-28	131.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
TLS3_k127_1487209_3	648757.Rvan_2357	7.881e-16	91.0	COG2358@1|root,COG2358@2|Bacteria,1Q1N5@1224|Proteobacteria,2U6X6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TRAP transporter solute receptor TAXI family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
TLS3_k127_1487209_0	1254432.SCE1572_25460	5.139e-116	377.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2YU1K@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
TLS3_k127_1487291_0	638303.Thal_0065	5.836e-110	374.0	COG0591@1|root,COG0591@2|Bacteria,2G4MN@200783|Aquificae	200783|Aquificae	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS3_k127_1487291_1	83406.HDN1F_21330	3.4e-60	222.0	COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1S02C@1236|Gammaproteobacteria,1J81R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048
TLS3_k127_1487291_2	1121957.ATVL01000008_gene4422	7.658e-27	112.0	COG2267@1|root,COG2267@2|Bacteria,4PKB6@976|Bacteroidetes,47JMT@768503|Cytophagia	976|Bacteroidetes	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_1489419_3	1123508.JH636442_gene4072	3.695e-38	149.0	COG0534@1|root,COG0534@2|Bacteria,2IX5Q@203682|Planctomycetes	203682|Planctomycetes	V	COG0534 Na -driven multidrug efflux pump	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_1489419_1	1038866.KB902776_gene6250	1.605e-52	190.0	COG3832@1|root,COG3832@2|Bacteria,1RDMX@1224|Proteobacteria,2TSWJ@28211|Alphaproteobacteria,3JX1W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_1489419_4	1125699.HMPREF9194_02179	1.109e-08	67.0	COG3103@1|root,COG3103@2|Bacteria,2J6D9@203691|Spirochaetes	203691|Spirochaetes	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1489419_2	1232437.KL662043_gene2227	7.56e-52	194.0	COG3026@1|root,COG3026@2|Bacteria,1R2P2@1224|Proteobacteria,43DHF@68525|delta/epsilon subdivisions,2X8P9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
TLS3_k127_1489419_0	1209072.ALBT01000012_gene3274	9.986e-63	228.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Exporters of the RND superfamily	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS3_k127_1492262_1	204773.HEAR2443	2.405e-21	101.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,473K0@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
TLS3_k127_1492262_0	1038859.AXAU01000001_gene3142	4.208e-121	398.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,3JV4V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS3_k127_1510089_3	457570.Nther_1877	1.679e-19	98.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS3_k127_1510089_2	1168289.AJKI01000002_gene2322	5.649e-94	318.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,2FMPI@200643|Bacteroidia,3XJTB@558415|Marinilabiliaceae	976|Bacteroidetes	G	ATP-NAD kinase	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
TLS3_k127_1510089_1	518766.Rmar_0876	4.425e-113	393.0	COG1629@1|root,COG4771@2|Bacteria,4PIBS@976|Bacteroidetes,1FJ71@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	TonB dependent receptor	-	-	-	ko:K02014,ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.2	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
TLS3_k127_1510089_0	525244.HMPREF0023_2040	1.18e-158	509.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RQDY@1236|Gammaproteobacteria,3NIRF@468|Moraxellaceae	1236|Gammaproteobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
TLS3_k127_1519707_0	243231.GSU3016	3.964e-12	81.0	COG0823@1|root,COG2885@1|root,COG3291@1|root,COG4412@1|root,COG5492@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,COG5492@2|Bacteria,1PMFY@1224|Proteobacteria,42Y8D@68525|delta/epsilon subdivisions,2WUNZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
TLS3_k127_1519707_1	218284.CCDN010000001_gene445	0.0001356	56.0	COG4932@1|root,COG4932@2|Bacteria,1TQBI@1239|Firmicutes,4HBAT@91061|Bacilli,1ZD6Z@1386|Bacillus	91061|Bacilli	M	cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cna_B,Collagen_bind,Gram_pos_anchor,MucBP
TLS3_k127_1522237_3	1166018.FAES_2984	3.548e-16	86.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,47MTM@768503|Cytophagia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
TLS3_k127_1522237_2	985867.AEWF01000002_gene1543	3.478e-21	103.0	COG1211@1|root,COG1211@2|Bacteria,1QVXT@1224|Proteobacteria,2TWM4@28211|Alphaproteobacteria,47G6Q@766|Rickettsiales	766|Rickettsiales	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.60,4.6.1.12	ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS3_k127_1522237_0	1345697.M493_00750	1.549e-73	258.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,4H9NQ@91061|Bacilli,1WG3D@129337|Geobacillus	91061|Bacilli	S	Large family of predicted nucleotide-binding domains	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TRAM
TLS3_k127_1522237_1	1128398.Curi_c23140	2.042e-34	137.0	COG1329@1|root,COG1329@2|Bacteria,1V40K@1239|Firmicutes,24HHP@186801|Clostridia,268R1@186813|unclassified Clostridiales	186801|Clostridia	K	CarD-like/TRCF domain	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS3_k127_154714_0	1163398.AJJP01000168_gene1121	1.015e-84	289.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Bile acid sodium symporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
TLS3_k127_154714_1	555779.Dthio_PD3581	6.647e-62	233.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,42Q3U@68525|delta/epsilon subdivisions,2WJ18@28221|Deltaproteobacteria,2M9ZX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1560874_0	1265503.KB905167_gene1544	9.501e-47	182.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,2Q69M@267889|Colwelliaceae	1236|Gammaproteobacteria	P	NnrS protein	nnrS	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
TLS3_k127_1560874_2	640081.Dsui_0444	6.879e-18	91.0	COG2703@1|root,COG2703@2|Bacteria,1PE0A@1224|Proteobacteria,2VY23@28216|Betaproteobacteria,2KYYR@206389|Rhodocyclales	206389|Rhodocyclales	P	HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_1560874_1	259536.Psyc_0620	4.14e-37	144.0	arCOG14922@1|root,32SW8@2|Bacteria,1N0NY@1224|Proteobacteria,1SACT@1236|Gammaproteobacteria,3NRXE@468|Moraxellaceae	1236|Gammaproteobacteria	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
TLS3_k127_1561215_1	1304885.AUEY01000025_gene2746	8.84e-05	52.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
TLS3_k127_1561215_0	1458275.AZ34_12560	5.068e-11	69.0	COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,2WF7M@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS3_k127_1567795_1	161156.JQKW01000006_gene1070	2.069e-46	177.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GH0E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
TLS3_k127_1567795_0	929556.Solca_2406	1.607e-56	209.0	COG1231@1|root,COG1231@2|Bacteria,4NJP2@976|Bacteroidetes,1ITXC@117747|Sphingobacteriia	976|Bacteroidetes	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS3_k127_1568831_0	1121019.AUMN01000008_gene3219	7.644e-58	213.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,1WCH5@1268|Micrococcaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_1568831_1	648996.Theam_1094	3.567e-29	126.0	COG0682@1|root,COG0682@2|Bacteria,2G41A@200783|Aquificae	200783|Aquificae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS3_k127_1572476_0	56780.SYN_00888	6.697e-39	148.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2MRWI@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
TLS3_k127_1572476_1	264198.Reut_A0942	3.906e-08	64.0	COG1075@1|root,COG1075@2|Bacteria,1R75P@1224|Proteobacteria,2VU4P@28216|Betaproteobacteria,1KI3B@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
TLS3_k127_1578432_1	1307761.L21SP2_1771	3.156e-20	101.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS3_k127_1578432_0	1125863.JAFN01000001_gene2513	1.772e-79	284.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	pfam abc1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,RIO1
TLS3_k127_1580207_2	1121351.AUAP01000029_gene1633	2.914e-27	115.0	COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,2WH6G@28216|Betaproteobacteria,2KPNV@206351|Neisseriales	206351|Neisseriales	H	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS3_k127_1580207_1	391625.PPSIR1_10500	4.534e-30	124.0	COG1595@1|root,COG1595@2|Bacteria,1RHSF@1224|Proteobacteria,438JV@68525|delta/epsilon subdivisions,2X3UH@28221|Deltaproteobacteria,2YX4W@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	HTH_24,Sigma70_r2,Sigma70_r4_2
TLS3_k127_1580207_3	59374.Fisuc_0911	5.316e-14	81.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1580207_0	1297742.A176_02574	2.811e-70	254.0	COG4249@1|root,COG4249@2|Bacteria,1QX7K@1224|Proteobacteria,43AHW@68525|delta/epsilon subdivisions,2X5Y0@28221|Deltaproteobacteria,2YZCA@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
TLS3_k127_1581135_0	1232410.KI421412_gene312	1.993e-85	296.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,43RY9@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	rep	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_1586078_0	1048834.TC41_0249	2.271e-161	524.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,277VA@186823|Alicyclobacillaceae	91061|Bacilli	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS3_k127_1590097_0	203119.Cthe_2768	4.938e-188	599.0	COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria,1TPCI@1239|Firmicutes,24BBR@186801|Clostridia,3WI0V@541000|Ruminococcaceae	186801|Clostridia	T	PNKP adenylyltransferase domain, ligase domain	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
TLS3_k127_159545_1	1052684.PPM_4384	5.956e-20	97.0	COG2197@1|root,COG2197@2|Bacteria,1V207@1239|Firmicutes,4HG4K@91061|Bacilli,26RRA@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, Lux Regulon	ydfI	-	-	ko:K11624	ko02020,map02020	M00484	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS3_k127_159545_0	234621.RER_06160	2.98e-62	224.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4FU9K@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA21	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS3_k127_159952_0	313606.M23134_02417	5.839e-40	168.0	COG5316@1|root,COG5316@2|Bacteria,4NGER@976|Bacteroidetes,47MYA@768503|Cytophagia	976|Bacteroidetes	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
TLS3_k127_1604196_0	608538.HTH_0156	6.793e-63	242.0	COG1148@1|root,COG1290@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	napF	-	-	ko:K02572,ko:K02573,ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	CCG,Cytochrome_B,FAD_binding_6,Fer2,Fer4,Fer4_4,Fer4_5,Fer4_7,FlpD,NAD_binding_1
TLS3_k127_1612781_0	1121957.ATVL01000007_gene2030	8.112e-29	129.0	28MSN@1|root,2ZB0Y@2|Bacteria,4NHW7@976|Bacteroidetes,47KH0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VIT
TLS3_k127_1614062_0	880072.Desac_1362	2.1e-06	59.0	COG0642@1|root,COG2205@2|Bacteria,1N5YU@1224|Proteobacteria,42N55@68525|delta/epsilon subdivisions,2WKPF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_1614062_1	760154.Sulba_1578	0.0001975	48.0	COG3221@1|root,COG3221@2|Bacteria,1NPBT@1224|Proteobacteria,42R8P@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
TLS3_k127_1616340_1	1096546.WYO_2313	5.717e-39	152.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,1JRTR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_1616340_0	502025.Hoch_5369	3.829e-73	254.0	COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,42ZU5@68525|delta/epsilon subdivisions,2WV5X@28221|Deltaproteobacteria,2YUT0@29|Myxococcales	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_1616451_0	6087.XP_002165392.1	2.085e-05	49.0	KOG2712@1|root,KOG2712@2759|Eukaryota,3A20Q@33154|Opisthokonta,3BQG5@33208|Metazoa	33208|Metazoa	K	Activated RNA polymerase II transcriptional coactivator	SUB1	GO:0000981,GO:0001205,GO:0001228,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003700,GO:0003705,GO:0003712,GO:0003713,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005667,GO:0005730,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0060260,GO:0060261,GO:0060395,GO:0065007,GO:0070013,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	-	-	-	-	-	-	-	-	-	PC4
TLS3_k127_1617311_1	318586.Pden_1658	7.075e-27	114.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2PVYE@265|Paracoccus	28211|Alphaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS3_k127_1617311_0	665571.STHERM_c20430	8.75e-43	168.0	COG0300@1|root,COG0300@2|Bacteria,2J7XX@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_1617311_2	345219.Bcoa_0856	3.753e-17	88.0	COG2911@1|root,COG4412@1|root,COG2911@2|Bacteria,COG4412@2|Bacteria,1UHPT@1239|Firmicutes,4IS5N@91061|Bacilli	91061|Bacilli	M	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Gram_pos_anchor,YSIRK_signal
TLS3_k127_1632286_0	1121935.AQXX01000130_gene2515	4.884e-172	547.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1XN2E@135619|Oceanospirillales	135619|Oceanospirillales	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS3_k127_1632286_1	304371.MCP_0052	0.0002299	47.0	COG0642@1|root,COG2202@1|root,arCOG02329@1|root,arCOG02329@2157|Archaea,arCOG06192@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea,2Y7RQ@28890|Euryarchaeota,2NAGK@224756|Methanomicrobia	224756|Methanomicrobia	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS_3,PAS_9,Response_reg
TLS3_k127_1645781_0	927658.AJUM01000047_gene2886	1.03e-53	201.0	COG0621@1|root,COG0621@2|Bacteria,4NE0R@976|Bacteroidetes,2FM1T@200643|Bacteroidia,3XJD0@558415|Marinilabiliaceae	976|Bacteroidetes	J	Uncharacterized protein family UPF0004	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,UPF0004
TLS3_k127_164580_0	1123274.KB899428_gene1852	3.736e-26	110.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_1645824_0	1121896.JMLU01000021_gene747	9.765e-23	113.0	COG4733@1|root,COG4733@2|Bacteria,4PPGG@976|Bacteroidetes,1IKM3@117743|Flavobacteriia,2P0RW@237|Flavobacterium	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
TLS3_k127_1648429_1	340177.Cag_1261	1.252e-68	235.0	COG1045@1|root,COG1045@2|Bacteria	2|Bacteria	E	serine acetyltransferase	srpH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS3_k127_1648429_0	1123242.JH636435_gene1569	2.087e-231	724.0	COG0664@1|root,COG0664@2|Bacteria,2J2BH@203682|Planctomycetes	203682|Planctomycetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1649702_0	449447.MAE_13660	1.088e-05	55.0	COG1462@1|root,COG1462@2|Bacteria,1G2XT@1117|Cyanobacteria	1117|Cyanobacteria	M	protein involved in formation of curli polymers	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TLS3_k127_16508_0	717606.PaecuDRAFT_3374	6.535e-57	211.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,4HAN2@91061|Bacilli,26QBK@186822|Paenibacillaceae	91061|Bacilli	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS3_k127_16508_1	469616.FMAG_02171	9.496e-30	120.0	COG0615@1|root,COG0615@2|Bacteria,37A0X@32066|Fusobacteria	32066|Fusobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE2	-	2.7.7.39	ko:K00980	ko00564,map00564	-	R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
TLS3_k127_1666135_1	1289135.A966_08849	5.403e-34	131.0	COG0008@1|root,COG0008@2|Bacteria,2J5M7@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS3_k127_1666135_0	1333998.M2A_1970	7.983e-125	414.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,4BPQ9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS3_k127_1668228_0	1097668.BYI23_B006360	8.384e-90	306.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2VHG2@28216|Betaproteobacteria,1K33C@119060|Burkholderiaceae	28216|Betaproteobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TLS3_k127_1668228_1	1187851.A33M_4310	7.139e-24	106.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,3FD1X@34008|Rhodovulum	28211|Alphaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TLS3_k127_1671364_0	1469245.JFBG01000076_gene137	7.245e-86	299.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,SufE
TLS3_k127_1671364_2	757424.Hsero_0691	4.619e-07	61.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,474BW@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS3_k127_1671364_1	1121920.AUAU01000002_gene2144	6.802e-48	177.0	COG1127@1|root,COG1127@2|Bacteria,3Y45H@57723|Acidobacteria	57723|Acidobacteria	Q	pfam abc	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS3_k127_1672576_1	314230.DSM3645_07500	1.312e-06	55.0	COG3000@1|root,COG3000@2|Bacteria,2J0YN@203682|Planctomycetes	203682|Planctomycetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_1672576_0	720554.Clocl_4116	1.408e-23	101.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS3_k127_1673629_0	1408422.JHYF01000001_gene2968	7.102e-75	260.0	COG0204@1|root,COG0204@2|Bacteria,1UMJA@1239|Firmicutes,249AV@186801|Clostridia,36EYB@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC_1	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_1673629_1	981369.JQMJ01000004_gene6464	2.741e-13	71.0	COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria,2NHB6@228398|Streptacidiphilus	201174|Actinobacteria	S	Appr-1'-p processing enzyme	lppD	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Macro
TLS3_k127_1677191_0	515620.EUBELI_00818	1.162e-13	72.0	COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia,25XPE@186806|Eubacteriaceae	186801|Clostridia	N	Flagellar protein (FlbD)	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
TLS3_k127_1677191_1	1230342.CTM_20626	1.116e-08	63.0	COG1580@1|root,COG1580@2|Bacteria,1VGIJ@1239|Firmicutes,24QKS@186801|Clostridia,36KFD@31979|Clostridiaceae	186801|Clostridia	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
TLS3_k127_1681568_0	1042377.AFPJ01000042_gene1094	1.757e-16	87.0	COG1305@1|root,COG1305@2|Bacteria,1NEY1@1224|Proteobacteria,1SF7F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TLS3_k127_1681568_1	1336235.JAEG01000005_gene3588	1.976e-11	74.0	COG1409@1|root,COG1409@2|Bacteria,1QI4K@1224|Proteobacteria,2TV5Q@28211|Alphaproteobacteria,4BAD0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Metallophos
TLS3_k127_1686212_0	1192034.CAP_4581	2.912e-23	114.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
TLS3_k127_1691444_1	340177.Cag_1726	8.608e-10	67.0	COG0861@1|root,COG0861@2|Bacteria,1FEJG@1090|Chlorobi	1090|Chlorobi	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
TLS3_k127_1691444_0	1089551.KE386572_gene324	1.826e-32	131.0	COG4290@1|root,COG4290@2|Bacteria,1RI58@1224|Proteobacteria	1224|Proteobacteria	F	ribonuclease	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	Ribonuclease
TLS3_k127_1691444_2	1178537.BA1_11764	1.981e-08	60.0	COG2732@1|root,COG2732@2|Bacteria,1VFHP@1239|Firmicutes,4HS3R@91061|Bacilli,1ZJ2M@1386|Bacillus	91061|Bacilli	K	ribonuclease inhibitor	yrdF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03623	-	-	-	-	ko00000	-	-	-	Barstar
TLS3_k127_1694436_0	744872.Spica_0294	4.664e-97	334.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_1698709_0	1005999.GLGR_2309	1.773e-07	63.0	COG2755@1|root,COG2755@2|Bacteria,1MXSG@1224|Proteobacteria,1RQZT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	Z012_00180	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
TLS3_k127_1713613_0	1338011.BD94_0806	9.326e-93	316.0	COG1005@1|root,COG1005@2|Bacteria,4NGK7@976|Bacteroidetes,1HY4Q@117743|Flavobacteriia,34R23@308865|Elizabethkingia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
TLS3_k127_1714693_0	1449076.JOOE01000001_gene2145	1.06e-33	138.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,2K0J3@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
TLS3_k127_1714693_1	1122603.ATVI01000007_gene1503	2.729e-19	95.0	COG1309@1|root,COG1309@2|Bacteria,1RJ63@1224|Proteobacteria,1S8HV@1236|Gammaproteobacteria,1X7YD@135614|Xanthomonadales	135614|Xanthomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_1722064_1	243276.TPANIC_0567	7.915e-13	76.0	COG3334@1|root,COG3334@2|Bacteria,2J66F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM MgtE intracellular	flbB	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	-
TLS3_k127_1722064_0	225937.HP15_2130	9.116e-23	101.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,1SCNZ@1236|Gammaproteobacteria,4693I@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG1734 DnaK suppressor protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
TLS3_k127_1722064_2	519989.ECTPHS_07277	1.567e-10	65.0	COG5274@1|root,COG5274@2|Bacteria	2|Bacteria	C	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5,FA_desaturase
TLS3_k127_1722064_3	55601.VANGNB10_cI0963	3.737e-05	50.0	COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,1RR7V@1236|Gammaproteobacteria,1XUW4@135623|Vibrionales	135623|Vibrionales	P	FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
TLS3_k127_1723312_0	478741.JAFS01000002_gene551	4.511e-217	681.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46SVA@74201|Verrucomicrobia,37FY0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_1724383_0	1232683.ADIMK_1233	3.636e-49	196.0	COG0642@1|root,COG3300@1|root,COG2205@2|Bacteria,COG3300@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,465FW@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_9,Response_reg
TLS3_k127_1726608_0	266117.Rxyl_0960	2.397e-69	238.0	COG0722@1|root,COG0722@2|Bacteria,2GMVF@201174|Actinobacteria,4CSEZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS3_k127_1728973_3	1347368.HG964404_gene5303	2.846e-12	72.0	COG1051@1|root,COG1051@2|Bacteria,1V9D6@1239|Firmicutes,4HICH@91061|Bacilli,1ZHU8@1386|Bacillus	91061|Bacilli	F	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_1728973_2	1120968.AUBX01000015_gene3731	9.801e-27	128.0	COG1629@1|root,COG1629@2|Bacteria,4PKVH@976|Bacteroidetes,47JB2@768503|Cytophagia	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug
TLS3_k127_1728973_0	1289135.A966_03830	3.41e-81	300.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1728973_1	716544.wcw_1517	8.337e-27	120.0	COG0030@1|root,COG0030@2|Bacteria,2JFY7@204428|Chlamydiae	204428|Chlamydiae	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS3_k127_1729607_0	666686.B1NLA3E_14565	2.938e-146	479.0	COG1205@1|root,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,4H9T2@91061|Bacilli,1ZDM5@1386|Bacillus	91061|Bacilli	L	COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS3_k127_1729747_0	1479235.KK366039_gene2992	5.125e-141	450.0	COG0642@1|root,COG2205@2|Bacteria,1QV1H@1224|Proteobacteria,1T4NM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS3_k127_1733249_0	596154.Alide2_0615	1.81e-16	81.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR66@28216|Betaproteobacteria,4AE1C@80864|Comamonadaceae	28216|Betaproteobacteria	U	PFAM type II secretion system protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
TLS3_k127_1733249_1	103690.17134312	7.035e-16	81.0	COG0745@1|root,COG2198@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2199@2|Bacteria,1G027@1117|Cyanobacteria,1HN0K@1161|Nostocales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Hpt,Response_reg,Trans_reg_C
TLS3_k127_1734984_2	1382358.JHVN01000001_gene772	1.934e-11	68.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,4HINR@91061|Bacilli,21X0U@150247|Anoxybacillus	91061|Bacilli	T	STAS domain	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
TLS3_k127_1734984_1	1121378.KB899699_gene1788	1.378e-27	114.0	COG2127@1|root,COG2127@2|Bacteria	2|Bacteria	T	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS3_k127_1734984_0	69279.BG36_10655	4.737e-46	175.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,43H2F@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS3_k127_1735452_1	1123274.KB899419_gene1882	8.201e-19	88.0	COG1551@1|root,COG1551@2|Bacteria,2J8VE@203691|Spirochaetes	203691|Spirochaetes	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
TLS3_k127_1735452_0	555779.Dthio_PD0521	5.384e-19	92.0	COG1699@1|root,COG1699@2|Bacteria,1N9E7@1224|Proteobacteria,42V88@68525|delta/epsilon subdivisions,2WR7H@28221|Deltaproteobacteria,2MC2W@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
TLS3_k127_1735452_2	1278309.KB907102_gene7	9.74e-18	83.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,1S6E7@1236|Gammaproteobacteria,1XPVA@135619|Oceanospirillales	135619|Oceanospirillales	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TLS3_k127_1750670_2	1266909.AUAG01000017_gene2524	2.783e-07	63.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWQV@135613|Chromatiales	135613|Chromatiales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_1750670_1	1382304.JNIL01000001_gene1846	3.905e-28	128.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli	91061|Bacilli	L	ATP-dependent DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_1750670_0	767434.Fraau_0334	4.387e-47	174.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1X3FM@135614|Xanthomonadales	135614|Xanthomonadales	F	Belongs to the RimK family	rimK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
TLS3_k127_1755262_2	1273103.NM10_10880	3.55e-20	91.0	COG1055@1|root,COG1055@2|Bacteria,1TT1V@1239|Firmicutes,4H35Q@909932|Negativicutes	909932|Negativicutes	P	COG1055 Na H antiporter NhaD and related arsenite permeases	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
TLS3_k127_1755262_0	491205.JARQ01000009_gene3548	1.407e-127	419.0	COG0330@1|root,COG0330@2|Bacteria,4NHKT@976|Bacteroidetes,1HWQ4@117743|Flavobacteriia,3ZNMK@59732|Chryseobacterium	976|Bacteroidetes	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS3_k127_1755262_1	1122176.KB903587_gene4469	1.333e-94	318.0	COG0061@1|root,COG0061@2|Bacteria,4NG3P@976|Bacteroidetes	976|Bacteroidetes	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
TLS3_k127_1755262_3	1499967.BAYZ01000163_gene6605	0.0004837	51.0	COG0642@1|root,COG2972@1|root,COG2205@2|Bacteria,COG2972@2|Bacteria,2NNXM@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	yclK	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023051,GO:0023052,GO:0023057,GO:0035556,GO:0036211,GO:0042802,GO:0042803,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046983,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070297,GO:0070298,GO:0071704,GO:0140096,GO:1901564,GO:1902531,GO:1902532	2.7.13.3	ko:K02484,ko:K07653,ko:K07654,ko:K11617	ko02020,map02020	M00460,M00461,M00481,M00754	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
TLS3_k127_1759909_0	1122605.KB893627_gene2914	1.998e-20	102.0	COG2515@1|root,COG2515@2|Bacteria,4NEP9@976|Bacteroidetes,1IQH5@117747|Sphingobacteriia	976|Bacteroidetes	E	1-aminocyclopropane-1-carboxylate deaminase	acdS	-	3.5.99.7	ko:K01505	ko00270,map00270	-	R00997	RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
TLS3_k127_1759909_1	1121918.ARWE01000001_gene1545	1.971e-19	93.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2WJ1H@28221|Deltaproteobacteria,43SDI@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Uncharacterized protein family UPF0004	mtaB	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
TLS3_k127_1765766_0	485917.Phep_1039	2.826e-66	255.0	COG4733@1|root,COG4932@1|root,COG4733@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	2.7.11.1,3.2.1.4	ko:K01179,ko:K12567,ko:K20276	ko00500,ko01100,ko02024,ko05410,ko05414,map00500,map01100,map02024,map05410,map05414	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	GH5,GH9	-	Big_3_2,Big_3_3,CHU_C,DUF4347,He_PIG,HemolysinCabind,SprB,fn3
TLS3_k127_1767069_0	497964.CfE428DRAFT_4279	5.597e-96	329.0	COG0773@1|root,COG0773@2|Bacteria,46THM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mur ligase middle domain protein	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_1767069_1	545695.TREAZ_1360	6.221e-74	264.0	COG1916@1|root,COG1916@2|Bacteria,2J5K2@203691|Spirochaetes	203691|Spirochaetes	S	Pheromone shutdown protein	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
TLS3_k127_1767069_2	1209989.TepiRe1_0424	8.095e-13	76.0	COG1716@1|root,COG1716@2|Bacteria,1VF0E@1239|Firmicutes,24P12@186801|Clostridia,42GKE@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Forkhead-associated	-	-	-	-	-	-	-	-	-	-	-	-	FHA
TLS3_k127_176956_1	929713.NIASO_04635	4.848e-47	174.0	COG0105@1|root,COG0105@2|Bacteria,4NM5B@976|Bacteroidetes,1ISC1@117747|Sphingobacteriia	976|Bacteroidetes	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
TLS3_k127_176956_0	1387312.BAUS01000002_gene261	6.729e-52	194.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,2KKBC@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS3_k127_176956_2	667014.Thein_0763	3.921e-42	165.0	COG1189@1|root,COG1189@2|Bacteria,2GGSK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS3_k127_176956_3	397278.JOJN01000003_gene1897	0.0002551	49.0	COG1595@1|root,COG1595@2|Bacteria,2INGP@201174|Actinobacteria,4DUJ1@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_1771296_1	497964.CfE428DRAFT_4648	4.082e-110	381.0	COG4191@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CBS,GAF,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_1771296_2	497964.CfE428DRAFT_4644	4.457e-39	149.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS3_k127_1771296_0	1265502.KB905953_gene759	3.135e-156	504.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGKF@28216|Betaproteobacteria,4AGRT@80864|Comamonadaceae	28216|Betaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
TLS3_k127_1778093_1	1123274.KB899413_gene856	0.0001109	46.0	COG1677@1|root,COG1677@2|Bacteria,2J8B3@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-basal body complex protein	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
TLS3_k127_1778093_0	573413.Spirs_1562	3.12e-68	250.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TLS3_k127_1780160_0	1444712.BN1013_00373	9.672e-143	470.0	COG0553@1|root,COG4889@1|root,COG0553@2|Bacteria,COG4889@2|Bacteria	2|Bacteria	L	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,DUF3991,HA,Helicase_C,Mrr_cat_2,N6_Mtase,PT-TG,ResIII,Toprim_2,VWA,YodL
TLS3_k127_1803092_0	251221.35210786	1.547e-17	87.0	COG1610@1|root,COG1610@2|Bacteria	2|Bacteria	S	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS3_k127_18031_1	391615.ABSJ01000017_gene1657	1.569e-78	269.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
TLS3_k127_18031_5	317936.Nos7107_2649	3.861e-06	51.0	2EK16@1|root,33DRP@2|Bacteria,1GJ1M@1117|Cyanobacteria,1HQ1Y@1161|Nostocales	1117|Cyanobacteria	S	SPTR Genome sequencing data, contig C323	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_18031_4	1121403.AUCV01000081_gene3759	1.158e-14	77.0	COG3668@1|root,COG3668@2|Bacteria,1N5BN@1224|Proteobacteria,43BD4@68525|delta/epsilon subdivisions,2X6S1@28221|Deltaproteobacteria,2MP1M@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS3_k127_18031_6	1541065.JRFE01000014_gene1450	0.0008189	52.0	COG4251@1|root,COG5000@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1G0A1@1117|Cyanobacteria,3VHNF@52604|Pleurocapsales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
TLS3_k127_18031_3	744872.Spica_2526	1.11e-30	138.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2JBDH@203691|Spirochaetes	2|Bacteria	KT	7TM diverse intracellular signalling	rsbW	-	2.4.1.12,3.1.3.3	ko:K00694,ko:K07315,ko:K20977	ko00500,ko01100,ko02020,ko02025,ko02026,map00500,map01100,map02020,map02025,map02026	M00820	R02889	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02022,ko03021	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	HATPase_c_2,MatE,SpoIIE
TLS3_k127_18031_0	880073.Calab_1416	1.279e-105	359.0	COG0591@1|root,COG0591@2|Bacteria,2NR0M@2323|unclassified Bacteria	2|Bacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
TLS3_k127_18031_2	760192.Halhy_4109	3.06e-40	151.0	COG0604@1|root,COG0604@2|Bacteria,4NHHT@976|Bacteroidetes,1IUX9@117747|Sphingobacteriia	976|Bacteroidetes	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_2,ADH_zinc_N_2
TLS3_k127_1803144_0	483219.LILAB_36240	3.062e-54	198.0	COG3000@1|root,COG3000@2|Bacteria,1NBCT@1224|Proteobacteria	1224|Proteobacteria	I	B domain of TMEM189, localisation domain	carF	-	-	ko:K20656	-	-	-	-	ko00000,ko04131	-	-	-	TMEM189_B_dmain
TLS3_k127_1804700_2	102129.Lepto7375DRAFT_2033	6.716e-07	54.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H7H2@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_1804700_1	765420.OSCT_0265	5.506e-37	160.0	COG0642@1|root,COG2203@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,2GBJ0@200795|Chloroflexi,37648@32061|Chloroflexia	32061|Chloroflexia	T	CHASE	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF_2,HATPase_c,HisKA,MASE1,PAS_4,Response_reg
TLS3_k127_1804700_0	1134474.O59_003636	1.727e-71	266.0	COG4251@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T5J8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
TLS3_k127_1806422_0	471854.Dfer_1175	8.41e-83	280.0	COG0477@1|root,COG2814@2|Bacteria,4NESW@976|Bacteroidetes,47JIH@768503|Cytophagia	976|Bacteroidetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_1806422_1	1298867.AUES01000046_gene4076	3.156e-10	66.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria,3JUY5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	MA20_38050	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_181847_0	59374.Fisuc_0534	6.544e-108	362.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.12	ko:K00694,ko:K00786	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_tranf_2_3
TLS3_k127_1824982_0	1386089.N865_01105	6.57e-36	144.0	COG0697@1|root,COG0697@2|Bacteria,2H1HG@201174|Actinobacteria,4FGHQ@85021|Intrasporangiaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3.2	-	-	EamA
TLS3_k127_1828657_0	1385935.N836_33600	9.394e-09	63.0	COG2059@1|root,COG2059@2|Bacteria,1G37Z@1117|Cyanobacteria,1HA7A@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TLS3_k127_1828657_1	102129.Lepto7375DRAFT_1972	2.286e-05	55.0	2EB14@1|root,3351Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1839099_0	278957.ABEA03000182_gene1971	1.576e-77	267.0	COG0483@1|root,COG0483@2|Bacteria,46V41@74201|Verrucomicrobia,3K741@414999|Opitutae	414999|Opitutae	G	Inositol monophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
TLS3_k127_1839099_2	15368.BRADI1G53000.1	2.056e-27	122.0	28IXY@1|root,2QR9K@2759|Eukaryota,37S7Y@33090|Viridiplantae,3GG0F@35493|Streptophyta,3KYPA@4447|Liliopsida,3I4KP@38820|Poales	35493|Streptophyta	S	Water Stress and Hypersensitive response	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
TLS3_k127_1839099_1	1191523.MROS_0340	6.554e-33	129.0	COG2151@1|root,COG2151@2|Bacteria	2|Bacteria	L	metal-sulfur cluster biosynthetic enzyme	paaD	-	-	ko:K02612,ko:K03593	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko03029,ko03036	-	-	-	FeS_assembly_P
TLS3_k127_184171_0	1519464.HY22_07215	1.415e-89	309.0	COG1398@1|root,COG1398@2|Bacteria	2|Bacteria	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS3_k127_184171_1	1274374.CBLK010000006_gene4499	2.865e-87	295.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli,26QZA@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the transamination of the aromatic amino acid forming a ketoacid	yugH	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_1842129_3	243275.TDE_1919	0.0002404	51.0	COG0731@1|root,COG0731@2|Bacteria,2JBHT@203691|Spirochaetes	203691|Spirochaetes	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	SPASM
TLS3_k127_1842129_2	443144.GM21_0199	5.26e-08	64.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PpiC-type peptidyl-prolyl cis-trans isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
TLS3_k127_1842129_1	1280689.AUJC01000001_gene2154	4.672e-29	131.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,36FVZ@31979|Clostridiaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS3_k127_1842129_0	666681.M301_0615	6.137e-83	280.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,2KKMR@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
TLS3_k127_1844246_0	909663.KI867150_gene1572	1.689e-34	137.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,2MQ4F@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS3_k127_1845838_2	1280706.AUJE01000009_gene793	3.711e-39	153.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,4H2V3@909932|Negativicutes	909932|Negativicutes	N	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS3_k127_1845838_1	1307761.L21SP2_1178	2.458e-49	187.0	COG1317@1|root,COG1317@2|Bacteria,2J5KZ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
TLS3_k127_1845838_0	665571.STHERM_c09110	2.836e-154	493.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
TLS3_k127_1845838_3	889378.Spiaf_2105	3.229e-24	104.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TLS3_k127_1848839_1	1279009.ADICEAN_01109	5.661e-23	99.0	COG2154@1|root,COG2154@2|Bacteria,4NS9U@976|Bacteroidetes,47RW0@768503|Cytophagia	976|Bacteroidetes	H	PFAM Pterin 4 alpha carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS3_k127_1848839_2	1313301.AUGC01000007_gene675	7.718e-17	87.0	2DBIE@1|root,32TXH@2|Bacteria,4NSJE@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1848839_0	452637.Oter_0266	3.783e-66	238.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	exoO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K16555,ko:K16564	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS3_k127_1860276_0	188626.HMPREF0321_1875	4.857e-36	146.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,1ZVVE@145357|Dermacoccaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
TLS3_k127_1860276_1	1278073.MYSTI_00468	2.717e-30	128.0	COG0558@1|root,COG2246@1|root,COG0558@2|Bacteria,COG2246@2|Bacteria,1N9TT@1224|Proteobacteria,42V2Q@68525|delta/epsilon subdivisions,2WRYY@28221|Deltaproteobacteria,2YWYE@29|Myxococcales	28221|Deltaproteobacteria	I	GtrA-like protein	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,GtrA
TLS3_k127_1861014_0	1449063.JMLS01000007_gene3577	1.874e-65	232.0	COG2207@1|root,COG2207@2|Bacteria,1V8GE@1239|Firmicutes,4HK8N@91061|Bacilli,26QMX@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_1861014_1	552811.Dehly_0458	5.76e-53	191.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_1865432_1	1242864.D187_006238	6.084e-31	124.0	2C5QS@1|root,2ZK8N@2|Bacteria,1RCN2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_1865432_0	223926.28806843	4.674e-49	183.0	28MIG@1|root,2ZAV8@2|Bacteria,1R5KD@1224|Proteobacteria,1S09N@1236|Gammaproteobacteria,1Y0ZH@135623|Vibrionales	135623|Vibrionales	S	EcsC protein family	-	-	-	-	-	-	-	-	-	-	-	-	EcsC
TLS3_k127_186597_2	880072.Desac_0717	1.523e-07	63.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MQRW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
TLS3_k127_186597_3	1469613.JT55_15590	1.102e-05	51.0	COG1366@1|root,COG1366@2|Bacteria,1MZE8@1224|Proteobacteria,2UBXI@28211|Alphaproteobacteria,3FEE7@34008|Rhodovulum	28211|Alphaproteobacteria	T	STAS domain	rsbV	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS3_k127_186597_1	984262.SGRA_1390	8.615e-111	377.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,1IWSD@117747|Sphingobacteriia	976|Bacteroidetes	M	COG2885 Outer membrane protein and related peptidoglycan-associated	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
TLS3_k127_186597_0	399795.CtesDRAFT_PD4295	1.236e-123	417.0	COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,2VM83@28216|Betaproteobacteria,4AB2K@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM pyruvate phosphate dikinase PEP pyruvate-binding	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
TLS3_k127_1867703_1	1047013.AQSP01000045_gene110	1.816e-55	199.0	COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905,iNJ661.Rv2130c	DALR_2,tRNA-synt_1e,tRNA-synt_1g
TLS3_k127_1867703_0	211114.JOEF01000013_gene4937	1.09e-67	235.0	COG0302@1|root,COG0302@2|Bacteria,2ID0X@201174|Actinobacteria	201174|Actinobacteria	H	GTP cyclohydrolase I	-	-	-	-	-	-	-	-	-	-	-	-	GTP_cyclohydroI
TLS3_k127_187039_0	521000.PROVRETT_07283	1.687e-63	226.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,3ZAGI@586|Providencia	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
TLS3_k127_187039_2	1121930.AQXG01000011_gene1773	2.878e-19	96.0	COG1514@1|root,COG1514@2|Bacteria,4NTUH@976|Bacteroidetes,1IUCJ@117747|Sphingobacteriia	976|Bacteroidetes	J	PFAM Phosphoesterase, HXTX	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS3_k127_187039_1	439235.Dalk_1565	9.789e-31	126.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,42P9B@68525|delta/epsilon subdivisions,2WMCP@28221|Deltaproteobacteria,2MMBX@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS3_k127_1879692_0	639282.DEFDS_1957	8.665e-119	396.0	COG0172@1|root,COG0172@2|Bacteria,2GEKS@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS3_k127_1879692_1	1125701.HMPREF1221_01925	5.693e-41	164.0	COG0564@1|root,COG0564@2|Bacteria,2J5SJ@203691|Spirochaetes	203691|Spirochaetes	J	S4 RNA-binding domain	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
TLS3_k127_1897433_1	243275.TDE_2279	1.766e-10	65.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_1897433_0	215803.DB30_8747	2.723e-14	86.0	COG4775@1|root,COG4775@2|Bacteria,1Q2CZ@1224|Proteobacteria,437ZA@68525|delta/epsilon subdivisions,2X399@28221|Deltaproteobacteria,2YUX9@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
TLS3_k127_1915023_0	765869.BDW_03945	8.112e-138	450.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2MTPM@213481|Bdellovibrionales,2WJVV@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	Hydrophobe amphiphile Efflux-1 (HAE1) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS3_k127_1915023_2	889378.Spiaf_2232	4.286e-07	57.0	291RI@1|root,2ZPBI@2|Bacteria,2J8IP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1915023_1	338966.Ppro_2659	5.788e-32	143.0	COG0591@1|root,COG2203@1|root,COG2208@1|root,COG0591@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1QTSW@1224|Proteobacteria,43CHB@68525|delta/epsilon subdivisions,2X7SG@28221|Deltaproteobacteria,43W3E@69541|Desulfuromonadales	28221|Deltaproteobacteria	EKT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,SSF,SpoIIE
TLS3_k127_1925861_1	521011.Mpal_0529	7.807e-12	69.0	COG1570@1|root,arCOG04513@2157|Archaea,2XVDP@28890|Euryarchaeota,2NAAC@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM Exonuclease VII large subunit	-	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS3_k127_1925861_0	1121875.KB907547_gene2916	5.705e-198	644.0	COG1335@1|root,COG2453@1|root,COG1335@2|Bacteria,COG2453@2|Bacteria,4NXZM@976|Bacteroidetes	976|Bacteroidetes	T	Dual specificity phosphatase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	CDKN3,DSPc
TLS3_k127_1927054_0	1307761.L21SP2_1813	2.053e-174	566.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS3_k127_1932019_0	1045858.Bint_1803	3.784e-165	531.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
TLS3_k127_1939017_1	1267535.KB906767_gene3997	0.0001317	53.0	28K54@1|root,2Z9TW@2|Bacteria,3Y3Z7@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1940938_1	1120951.AUBG01000002_gene1481	1.47e-20	104.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZK0@117743|Flavobacteriia	976|Bacteroidetes	K	AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_1940938_0	930169.B5T_01229	1.345e-43	168.0	COG0654@1|root,COG0654@2|Bacteria,1MX9R@1224|Proteobacteria,1SYDP@1236|Gammaproteobacteria,1XNTQ@135619|Oceanospirillales	135619|Oceanospirillales	CH	FAD binding domain	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS3_k127_1942071_1	59538.XP_005973823.1	8.761e-100	332.0	COG0555@1|root,2S1I2@2759|Eukaryota	2759|Eukaryota	O	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
TLS3_k127_1942071_0	582744.Msip34_2159	5.948e-111	367.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2VI3S@28216|Betaproteobacteria,2KM7E@206350|Nitrosomonadales	206350|Nitrosomonadales	P	TIGRFAM sulfate ABC transporter, inner membrane subunit CysW	-	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
TLS3_k127_1944411_0	1120980.JQKH01000009_gene1403	1.053e-143	461.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2VK95@28216|Betaproteobacteria,2KQR4@206351|Neisseriales	206351|Neisseriales	C	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3,Cytochrom_C,Cytochrome_CBB3
TLS3_k127_1944411_1	547045.NEISICOT_01653	8.352e-40	154.0	COG1262@1|root,COG1262@2|Bacteria,1RAP4@1224|Proteobacteria,2VNNP@28216|Betaproteobacteria,2KQB8@206351|Neisseriales	206351|Neisseriales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS3_k127_194566_0	388467.A19Y_0072	1.278e-61	227.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1FZXP@1117|Cyanobacteria,1H9FJ@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
TLS3_k127_1951831_1	1144319.PMI16_02869	5.115e-05	53.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4736W@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
TLS3_k127_1951831_0	391615.ABSJ01000017_gene1695	4.449e-84	309.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1S0TD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Hpt domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Hpt
TLS3_k127_195655_0	526224.Bmur_1642	2.089e-41	167.0	COG1454@1|root,COG1454@2|Bacteria,2J5ZT@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	eutG	-	1.1.1.1	ko:K13954,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS3_k127_1957392_4	391625.PPSIR1_38866	4.297e-06	57.0	COG5184@1|root,COG5184@2|Bacteria,1QZTG@1224|Proteobacteria	2|Bacteria	DZ	Domain of unknown function (DUF4215)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4215,Fibrinogen_C,RCC1_2,TSP_3
TLS3_k127_1957392_0	690585.JNNU01000005_gene3188	1.384e-123	405.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TSKV@28211|Alphaproteobacteria,4B7JY@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldo keto reductase	tas	GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_1957392_2	1396141.BATP01000005_gene5962	6.143e-11	70.0	COG1595@1|root,COG1595@2|Bacteria,46WAM@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_1957392_1	240016.ABIZ01000001_gene2232	4.625e-46	172.0	COG2259@1|root,COG2259@2|Bacteria,46T2M@74201|Verrucomicrobia,2IUPP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS3_k127_1957392_3	1283283.ATXA01000005_gene2169	9.392e-10	61.0	COG1846@1|root,COG1846@2|Bacteria,2IMUX@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS3_k127_1958483_0	744872.Spica_1970	1.596e-33	143.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS3_k127_1964721_1	1121924.ATWH01000013_gene556	0.0009356	49.0	COG0288@1|root,COG0288@2|Bacteria,2GT5H@201174|Actinobacteria,4FMPN@85023|Microbacteriaceae	201174|Actinobacteria	P	Reversible hydration of carbon dioxide	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS3_k127_1964721_0	700598.Niako_3481	7.146e-30	123.0	COG0659@1|root,COG0659@2|Bacteria,4NE9G@976|Bacteroidetes,1INYY@117747|Sphingobacteriia	976|Bacteroidetes	P	COGs COG0659 Sulfate permease and related transporter (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TLS3_k127_1966968_0	644966.Tmar_1056	1.059e-70	246.0	COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,25EG8@186801|Clostridia,3WDQS@538999|Clostridiales incertae sedis	186801|Clostridia	KL	PFAM Helicase conserved C-terminal domain	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS3_k127_1966968_1	1415779.JOMH01000001_gene2425	9.066e-56	207.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1X587@135614|Xanthomonadales	135614|Xanthomonadales	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
TLS3_k127_1966968_2	1123367.C666_01375	6.063e-37	147.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VH4T@28216|Betaproteobacteria,2KUMD@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the SUA5 family	yrdC	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
TLS3_k127_1966968_3	1123008.KB905700_gene2136	3.744e-05	48.0	COG0262@1|root,COG0262@2|Bacteria,4NMP3@976|Bacteroidetes,2G2VQ@200643|Bacteroidia,2308I@171551|Porphyromonadaceae	976|Bacteroidetes	H	RibD C-terminal domain	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
TLS3_k127_1966968_4	388467.A19Y_1704	0.0004827	43.0	COG0604@1|root,COG0604@2|Bacteria,1FZW8@1117|Cyanobacteria,1H6ZN@1150|Oscillatoriales	1117|Cyanobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
TLS3_k127_1967097_0	498761.HM1_2362	1.052e-21	108.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia	186801|Clostridia	KT	stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	MASE3,PAS_4,PAS_9,SpoIIE
TLS3_k127_197424_0	1302858.I871_02185	6.644e-20	102.0	COG2199@1|root,COG3706@2|Bacteria,2J7V5@203691|Spirochaetes	203691|Spirochaetes	T	response	rrp-1	-	-	ko:K18444	ko02020,map02020	M00662	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GGDEF,Hpt,Response_reg
TLS3_k127_1980328_0	471854.Dfer_3672	8.96e-172	556.0	COG0119@1|root,COG0119@2|Bacteria,4NF3N@976|Bacteroidetes,47JWF@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA_1	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS3_k127_1980328_1	118173.KB235910_gene4582	2.807e-23	103.0	COG1225@1|root,COG1225@2|Bacteria,1G6V9@1117|Cyanobacteria	1117|Cyanobacteria	O	AhpC TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS3_k127_1983571_0	1232410.KI421426_gene1485	3.823e-103	350.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2WJBJ@28221|Deltaproteobacteria,43T2K@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
TLS3_k127_1983571_1	1237149.C900_04365	1.521e-29	126.0	COG1629@1|root,COG4771@2|Bacteria,4NM9G@976|Bacteroidetes,47UNA@768503|Cytophagia	976|Bacteroidetes	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TLS3_k127_1989821_2	1227739.Hsw_2562	4.376e-24	110.0	COG0348@1|root,COG0348@2|Bacteria,4NHSX@976|Bacteroidetes,47KC5@768503|Cytophagia	976|Bacteroidetes	C	4Fe-4S dicluster domain	yccM_2	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7,Fer4_9
TLS3_k127_1989821_0	1313421.JHBV01000029_gene2018	1.037e-73	265.0	COG2124@1|root,COG2124@2|Bacteria,4NG9Z@976|Bacteroidetes,1IVH3@117747|Sphingobacteriia	976|Bacteroidetes	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_1989821_1	56780.SYN_00756	8.868e-34	134.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535,ko:K13599	ko00540,ko01100,ko02020,map00540,map01100,map02020	M00060,M00498	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005,ko02022	-	-	-	LpxC
TLS3_k127_1991108_0	1397528.Q671_16540	1.536e-07	63.0	COG3307@1|root,COG3307@2|Bacteria,1R8PC@1224|Proteobacteria,1RYYV@1236|Gammaproteobacteria,1XM65@135619|Oceanospirillales	135619|Oceanospirillales	M	O-Antigen ligase	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
TLS3_k127_1993816_1	471854.Dfer_3475	1.658e-41	156.0	COG5557@1|root,COG5557@2|Bacteria,4NE3X@976|Bacteroidetes,47K18@768503|Cytophagia	976|Bacteroidetes	C	PFAM Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
TLS3_k127_1993816_0	1184267.A11Q_1511	1.631e-210	690.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2MTN3@213481|Bdellovibrionales,2WKHA@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	iron-sulfur binding	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS3_k127_1993816_2	765869.BDW_05535	4.635e-40	156.0	COG3303@1|root,COG3303@2|Bacteria,1QY22@1224|Proteobacteria,43C9D@68525|delta/epsilon subdivisions,2MTWU@213481|Bdellovibrionales,2WQ1C@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
TLS3_k127_1993816_3	1397527.Q670_09810	7.227e-15	81.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1XKJR@135619|Oceanospirillales	135619|Oceanospirillales	P	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
TLS3_k127_1993867_0	583345.Mmol_1914	4.479e-120	402.0	COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2VIIA@28216|Betaproteobacteria,2KNJS@206350|Nitrosomonadales	206350|Nitrosomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS3_k127_2006071_0	1415780.JPOG01000001_gene1552	7.97e-43	167.0	COG3687@1|root,COG3687@2|Bacteria,1R4HJ@1224|Proteobacteria,1T08A@1236|Gammaproteobacteria,1XCZ7@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Metal_hydrol
TLS3_k127_2007170_1	760192.Halhy_0958	8.635e-32	126.0	29E7I@1|root,3015I@2|Bacteria,4NNFG@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
TLS3_k127_2007170_2	1395516.PMO01_09580	5.717e-28	119.0	COG3556@1|root,COG3556@2|Bacteria,1N0ZZ@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	ko:K08983	-	-	-	-	ko00000	-	-	-	DUF2214
TLS3_k127_2007170_3	953739.SVEN_6975	1.259e-13	78.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS3_k127_2007170_5	313603.FB2170_00120	2.417e-10	68.0	COG1309@1|root,COG1309@2|Bacteria,4NM7T@976|Bacteroidetes,1II6H@117743|Flavobacteriia	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_2007170_4	573413.Spirs_1445	5.268e-13	71.0	28N6F@1|root,2ZBBB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2007170_0	862908.BMS_0888	7.91e-94	319.0	COG0535@1|root,COG0535@2|Bacteria,1N2I6@1224|Proteobacteria,42P9K@68525|delta/epsilon subdivisions,2MSVJ@213481|Bdellovibrionales,2WQ2D@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
TLS3_k127_2007170_6	1144275.COCOR_04904	0.0001139	55.0	COG3055@1|root,COG3055@2|Bacteria,1MYQG@1224|Proteobacteria,42P3T@68525|delta/epsilon subdivisions,2WKUC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,PKD
TLS3_k127_2007299_1	266265.Bxe_B0733	0.0002538	53.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,1K42M@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	type I secretion outer membrane protein, TolC	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TLS3_k127_2007299_0	1192034.CAP_8251	1.359e-23	108.0	COG1280@1|root,COG1280@2|Bacteria	2|Bacteria	E	homoserine transmembrane transporter activity	yahN	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039	-	ko:K03329,ko:K16327	-	-	-	-	ko00000,ko02000	2.A.76.1.3,2.A.76.1.6	-	-	LysE
TLS3_k127_2010861_1	1492922.GY26_16955	8.538e-10	62.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1J4DX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_2010861_0	765869.BDW_03880	8.408e-46	182.0	COG2114@1|root,COG2770@1|root,COG2114@2|Bacteria,COG2770@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2MUNS@213481|Bdellovibrionales,2WPIY@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_2013129_0	1353529.M899_0636	2.302e-13	78.0	COG3219@1|root,COG3219@2|Bacteria,1Q6FK@1224|Proteobacteria,43323@68525|delta/epsilon subdivisions,2MUKX@213481|Bdellovibrionales,2WXNC@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
TLS3_k127_2015142_1	404589.Anae109_2925	2.117e-25	119.0	COG1404@1|root,COG3940@1|root,COG1404@2|Bacteria,COG3940@2|Bacteria,1RCVP@1224|Proteobacteria	1224|Proteobacteria	O	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
TLS3_k127_2015142_0	1380394.JADL01000001_gene2301	1.054e-43	163.0	COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2U607@28211|Alphaproteobacteria,2JTQH@204441|Rhodospirillales	204441|Rhodospirillales	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
TLS3_k127_2018868_1	543728.Vapar_2862	2.312e-13	73.0	COG0824@1|root,COG2153@1|root,COG0824@2|Bacteria,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,4A9NN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Thioesterase superfamily protein	yjcF	-	-	-	-	-	-	-	-	-	-	-	4HBT,Acetyltransf_10
TLS3_k127_2018868_0	309807.SRU_0770	3.239e-47	183.0	COG2850@1|root,COG2850@2|Bacteria,4PEBP@976|Bacteroidetes,1FIRX@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	A domain family that is part of the cupin metalloenzyme superfamily.	-	-	1.14.11.47	ko:K18850	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cupin_4
TLS3_k127_2031279_1	1123256.KB907925_gene1416	0.0005948	42.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1X57A@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_2032036_0	379066.GAU_1656	1.492e-67	242.0	COG0243@1|root,COG1034@1|root,COG0243@2|Bacteria,COG1034@2|Bacteria,1ZTDW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
TLS3_k127_2037891_1	1254432.SCE1572_41035	1.456e-54	198.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2WPIY@28221|Deltaproteobacteria,2Z0N9@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_2037891_0	1121912.AUHD01000007_gene535	3.446e-64	225.0	COG0225@1|root,COG0225@2|Bacteria,4NI9D@976|Bacteroidetes,1I0XI@117743|Flavobacteriia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS3_k127_2048393_0	1205680.CAKO01000040_gene758	2.08e-225	705.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2JPS3@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS3_k127_2048393_1	518766.Rmar_0505	5.854e-06	55.0	2DSWV@1|root,33HR1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2056814_1	880526.KE386488_gene1890	9.291e-95	333.0	COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,2FM0A@200643|Bacteroidia,22U9Y@171550|Rikenellaceae	976|Bacteroidetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	pgcA	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_2056814_2	1210884.HG799465_gene12209	1.812e-70	246.0	COG0149@1|root,COG0149@2|Bacteria,2IXV9@203682|Planctomycetes	203682|Planctomycetes	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS3_k127_2056814_0	264462.Bd0709	6.792e-222	706.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2MTI3@213481|Bdellovibrionales,2X727@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
TLS3_k127_2057892_2	1033734.CAET01000048_gene1734	3.404e-10	70.0	COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,4HBHB@91061|Bacilli,1ZANH@1386|Bacillus	91061|Bacilli	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0017057,GO:0044424,GO:0044444,GO:0044464,GO:0052689	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
TLS3_k127_2057892_0	1318628.MARLIPOL_13209	2.403e-94	315.0	COG0625@1|root,COG0625@2|Bacteria,1R7YC@1224|Proteobacteria,1S06X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0695 Glutaredoxin and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GST_N_3
TLS3_k127_2057892_1	9823.ENSSSCP00000025048	2.203e-13	80.0	COG0666@1|root,KOG0504@2759|Eukaryota,39YNX@33154|Opisthokonta,3B9NB@33208|Metazoa,3CRFJ@33213|Bilateria,47ZCI@7711|Chordata,48Y1R@7742|Vertebrata,3J4BP@40674|Mammalia,4IWCE@91561|Cetartiodactyla	33208|Metazoa	S	Ankyrin repeat domain 52	ANKRD52	-	-	ko:K15502,ko:K15504	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
TLS3_k127_2062639_0	378806.STAUR_6357	1.104e-41	165.0	COG0464@1|root,COG0464@2|Bacteria,1RCHW@1224|Proteobacteria,42Z41@68525|delta/epsilon subdivisions,2WU9F@28221|Deltaproteobacteria,2YUT7@29|Myxococcales	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS3_k127_2065874_0	1121935.AQXX01000131_gene2861	1.774e-128	420.0	COG3239@1|root,COG3239@2|Bacteria,1QKDT@1224|Proteobacteria,1RQCX@1236|Gammaproteobacteria,1XNQW@135619|Oceanospirillales	135619|Oceanospirillales	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS3_k127_2065925_0	71421.HI_0856	2.472e-141	477.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1Y7ZN@135625|Pasteurellales	135625|Pasteurellales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS3_k127_2067217_0	1049564.TevJSym_av00090	5.196e-29	124.0	COG1360@1|root,COG1360@2|Bacteria,1QUFR@1224|Proteobacteria,1T1XE@1236|Gammaproteobacteria,1J4JC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS3_k127_2077895_0	1094715.CM001373_gene1530	1.272e-21	109.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria,1JD07@118969|Legionellales	118969|Legionellales	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS3_k127_2087509_0	880073.Calab_3489	2.501e-53	193.0	COG0503@1|root,COG0503@2|Bacteria,2NPGX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	PRTase_2,Pribosyltran,TRSP
TLS3_k127_2087509_1	1128398.Curi_c18310	6.488e-25	109.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,267TN@186813|unclassified Clostridiales	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TLS3_k127_2091380_0	709032.Sulku_1307	3.496e-15	86.0	COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,42YPK@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,CHASE8,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
TLS3_k127_2091974_0	697282.Mettu_1987	1.483e-20	106.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	3.4.14.5	ko:K01278,ko:K03561,ko:K12287	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
TLS3_k127_2105293_0	665571.STHERM_c08540	2.164e-74	261.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	2|Bacteria	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_2107088_1	445970.ALIPUT_02763	1.037e-09	65.0	COG1390@1|root,COG1390@2|Bacteria,4NTEY@976|Bacteroidetes,2G2KK@200643|Bacteroidia,22UJC@171550|Rikenellaceae	976|Bacteroidetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_B,vATP-synt_E
TLS3_k127_2107088_0	526224.Bmur_1549	1.65e-31	134.0	COG1527@1|root,COG1527@2|Bacteria	2|Bacteria	C	subunit (C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	DUF2764,vATP-synt_AC39
TLS3_k127_2108458_0	1157490.EL26_15355	5.134e-142	458.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli,2796G@186823|Alicyclobacillaceae	91061|Bacilli	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS3_k127_2113943_0	391615.ABSJ01000038_gene415	3.951e-44	166.0	2E3JJ@1|root,32YHY@2|Bacteria,1RBEW@1224|Proteobacteria,1S2II@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2113943_1	880072.Desac_1083	4.296e-16	83.0	COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,42W96@68525|delta/epsilon subdivisions,2WRIB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CBS domain	-	-	-	ko:K04767,ko:K07168,ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
TLS3_k127_2114350_1	1166018.FAES_2826	3.948e-13	75.0	COG0517@1|root,COG0517@2|Bacteria,4PM6K@976|Bacteroidetes,47YG9@768503|Cytophagia	976|Bacteroidetes	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS3_k127_2114350_0	768706.Desor_1151	2.883e-19	100.0	2EDX0@1|root,337S1@2|Bacteria,1VEE7@1239|Firmicutes	1239|Firmicutes	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
TLS3_k127_2114448_2	1480694.DC28_10570	8.422e-20	103.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
TLS3_k127_2114448_0	1353529.M899_2547	2.386e-41	168.0	COG2866@1|root,COG2866@2|Bacteria,1NW73@1224|Proteobacteria,42QG0@68525|delta/epsilon subdivisions,2MSW3@213481|Bdellovibrionales,2WJE5@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS3_k127_2114448_1	1485545.JQLW01000008_gene2091	8.48e-30	129.0	COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria	1224|Proteobacteria	L	Hemolysin	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5,Acyltransferase
TLS3_k127_2120254_1	244582.JQAK01000004_gene285	1.173e-49	186.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2TRPS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS3_k127_2120254_0	59538.XP_005966061.1	7.422e-106	349.0	COG4799@1|root,KOG0540@2759|Eukaryota,38ET3@33154|Opisthokonta,3BEEB@33208|Metazoa,3CXQG@33213|Bilateria,482A2@7711|Chordata,490P9@7742|Vertebrata,3J3F4@40674|Mammalia,4J2PX@91561|Cetartiodactyla	33208|Metazoa	EI	methylcrotonoyl-CoA carboxylase beta chain	-	GO:0003674,GO:0003824,GO:0004485,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0007563,GO:0008150,GO:0008152,GO:0009081,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050793,GO:0051239,GO:0065007,GO:0070013,GO:0071704,GO:1901564,GO:1901605,GO:2000026	6.4.1.4	ko:K01969,ko:K17425	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	Carboxyl_trans
TLS3_k127_2128167_1	243231.GSU1003	4.955e-05	49.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43U5W@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	gnfM	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_2128167_0	502025.Hoch_0105	6.89e-10	70.0	COG2204@1|root,COG2204@2|Bacteria,1R0E3@1224|Proteobacteria,43CWJ@68525|delta/epsilon subdivisions,2WSIM@28221|Deltaproteobacteria,2YW6V@29|Myxococcales	2|Bacteria	T	response regulator	-	-	-	ko:K02282,ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022,ko02035,ko02044	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HTH_8,HisKA,PAS_7,PAS_9,Response_reg,Sigma54_activ_2,V4R,XylR_N
TLS3_k127_2138388_0	768710.DesyoDRAFT_0216	4.236e-83	281.0	COG0564@1|root,COG0564@2|Bacteria,1TSPG@1239|Firmicutes,24D6E@186801|Clostridia,260NQ@186807|Peptococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_2144239_0	760192.Halhy_4143	5.475e-195	618.0	COG0579@1|root,COG0579@2|Bacteria,4NH56@976|Bacteroidetes,1IRCW@117747|Sphingobacteriia	976|Bacteroidetes	C	malate quinone oxidoreductase	mqo	-	1.1.5.4	ko:K00116	ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00360,R00361,R01257	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Mqo
TLS3_k127_2145221_0	765869.BDW_03945	1.088e-213	678.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2MTPM@213481|Bdellovibrionales,2WJVV@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	Hydrophobe amphiphile Efflux-1 (HAE1) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS3_k127_2156276_1	1397696.KK211189_gene2556	0.0001022	49.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2156276_0	1515613.HQ37_06330	8.103e-26	119.0	COG1947@1|root,COG1947@2|Bacteria,4NGFC@976|Bacteroidetes,2FM2B@200643|Bacteroidia,22X69@171551|Porphyromonadaceae	976|Bacteroidetes	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS3_k127_2160071_1	511680.BUTYVIB_01074	1.88e-07	61.0	COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,24A6U@186801|Clostridia	186801|Clostridia	S	Methyltransferase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_2160071_0	59538.XP_005977594.1	2.908e-21	107.0	2E2WG@1|root,2SA2N@2759|Eukaryota	2759|Eukaryota	S	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
TLS3_k127_2160071_3	411473.RUMCAL_02709	0.0001169	54.0	COG2247@1|root,COG2247@2|Bacteria	2|Bacteria	M	cell wall organization	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Peptidase_M15_4,SLH
TLS3_k127_2161142_0	880073.Calab_2460	9.489e-105	348.0	COG0446@1|root,COG0446@2|Bacteria,2NPPU@2323|unclassified Bacteria	2|Bacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
TLS3_k127_216532_1	1111121.HMPREF1247_0984	2.687e-05	54.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4CV3I@84998|Coriobacteriia	84998|Coriobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS3_k127_216532_0	1322246.BN4_10128	1.056e-27	119.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2WQNR@28221|Deltaproteobacteria,2MBWB@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
TLS3_k127_216996_0	1198114.AciX9_0201	8.717e-07	57.0	COG2374@1|root,COG2374@2|Bacteria,3Y6HZ@57723|Acidobacteria,2JKTB@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	DUF1573,Exo_endo_phos,LTD
TLS3_k127_217265_0	929556.Solca_2747	3.804e-124	403.0	COG0306@1|root,COG0306@2|Bacteria,4NE7J@976|Bacteroidetes,1IPR3@117747|Sphingobacteriia	976|Bacteroidetes	P	phosphate transporter	pitA	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
TLS3_k127_217265_1	1242864.D187_003808	1.015e-40	160.0	COG4850@1|root,COG4850@2|Bacteria,1NYAE@1224|Proteobacteria,430HM@68525|delta/epsilon subdivisions,2WW1X@28221|Deltaproteobacteria,2YUT1@29|Myxococcales	28221|Deltaproteobacteria	S	conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2172812_1	714313.LSA_07390	1.811e-14	75.0	COG0187@1|root,COG0187@2|Bacteria,1TQCF@1239|Firmicutes,4H9UC@91061|Bacilli,3F430@33958|Lactobacillaceae	91061|Bacilli	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS3_k127_2172812_0	1480694.DC28_14880	1.412e-29	131.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS3_k127_2172827_0	526224.Bmur_0184	7.329e-38	152.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TLS3_k127_2172827_1	1449050.JNLE01000003_gene3615	6.276e-20	92.0	COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,24QJR@186801|Clostridia,36KJW@31979|Clostridiaceae	186801|Clostridia	N	Flagellar biosynthetic protein FliQ	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
TLS3_k127_2173893_0	215803.DB30_5374	4.325e-27	124.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,2YU60@29|Myxococcales	28221|Deltaproteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA2	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS3_k127_2173929_1	1192034.CAP_6021	9.909e-29	117.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42QTM@68525|delta/epsilon subdivisions,2WN5R@28221|Deltaproteobacteria,2YZM4@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_2173929_0	1485545.JQLW01000010_gene1663	3.916e-35	140.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria	1224|Proteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_2173929_2	1453503.AU05_00780	1.135e-07	56.0	2C39R@1|root,32UYY@2|Bacteria,1N8ND@1224|Proteobacteria,1SGWD@1236|Gammaproteobacteria,1YGXH@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_218109_6	1123386.AUIW01000009_gene1812	5.103e-11	68.0	COG1848@1|root,COG1848@2|Bacteria,1WKJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_218109_5	83219.PM02_12105	4.71e-14	78.0	COG0457@1|root,COG0457@2|Bacteria,1NCSM@1224|Proteobacteria,2UGJ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_218109_1	999541.bgla_1g26390	2.081e-77	276.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,2WFU5@28216|Betaproteobacteria,1KI63@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
TLS3_k127_218109_2	118161.KB235922_gene4460	2.509e-54	200.0	COG0300@1|root,COG0300@2|Bacteria,1G1Z0@1117|Cyanobacteria,3VJG7@52604|Pleurocapsales	1117|Cyanobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_218109_4	1123277.KB893185_gene3038	9.439e-20	101.0	COG4977@1|root,COG4977@2|Bacteria,4PP1N@976|Bacteroidetes	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_218109_3	1249480.B649_05405	2.306e-44	175.0	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1R7HC@1224|Proteobacteria,42YVM@68525|delta/epsilon subdivisions,2YRBE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	KT	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
TLS3_k127_218109_0	1415774.U728_3195	2.623e-165	537.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,36FS8@31979|Clostridiaceae	186801|Clostridia	H	Acetolactate synthase, large subunit, biosynthetic	ilvB2	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_218109_7	196367.JNFG01000021_gene4943	1.684e-05	56.0	COG4254@1|root,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VMS2@28216|Betaproteobacteria,1K26R@119060|Burkholderiaceae	28216|Betaproteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
TLS3_k127_2182999_1	290397.Adeh_4247	3.44e-21	101.0	COG2267@1|root,COG2267@2|Bacteria,1PXRQ@1224|Proteobacteria,434SS@68525|delta/epsilon subdivisions,2X90B@28221|Deltaproteobacteria,2Z19P@29|Myxococcales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_2182999_0	382464.ABSI01000013_gene1716	1.13e-69	246.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_2186775_0	157072.XP_008861208.1	2.589e-118	400.0	28VX6@1|root,2R2P1@2759|Eukaryota	2759|Eukaryota	S	Metallo-beta-lactamase superfamily	-	GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006198,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008081,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009187,GO:0009214,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019932,GO:0019933,GO:0019934,GO:0019935,GO:0023052,GO:0032101,GO:0033036,GO:0034404,GO:0034613,GO:0034641,GO:0034654,GO:0034655,GO:0035556,GO:0040012,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046058,GO:0046434,GO:0046483,GO:0046700,GO:0047555,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0050926,GO:0051179,GO:0051641,GO:0051716,GO:0055086,GO:0061118,GO:0065007,GO:0070727,GO:0071704,GO:0072521,GO:0072523,GO:0072697,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1990778	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2,cNMP_binding
TLS3_k127_2189458_0	316067.Geob_0888	1.69e-05	57.0	COG3297@1|root,COG3297@2|Bacteria	2|Bacteria	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
TLS3_k127_2190079_0	1192034.CAP_6367	3.966e-82	283.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,43AHM@68525|delta/epsilon subdivisions,2X5XU@28221|Deltaproteobacteria,2YU25@29|Myxococcales	28221|Deltaproteobacteria	U	Sulfate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TLS3_k127_2190243_0	395494.Galf_2257	1.556e-53	195.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,44V81@713636|Nitrosomonadales	28216|Betaproteobacteria	F	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS3_k127_219245_4	926562.Oweho_0390	0.0008582	48.0	COG2885@1|root,COG3063@1|root,COG2885@2|Bacteria,COG3063@2|Bacteria,4NE6G@976|Bacteroidetes,1INKT@117743|Flavobacteriia,2PA4S@246874|Cryomorphaceae	976|Bacteroidetes	MNU	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
TLS3_k127_219245_0	891968.Anamo_1586	1.394e-204	661.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3TA4P@508458|Synergistetes	508458|Synergistetes	G	PFAM glycosyl transferase family 20	-	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
TLS3_k127_219245_2	886377.Murru_2889	3.178e-50	183.0	COG4898@1|root,COG4898@2|Bacteria,4NQGY@976|Bacteroidetes,1I2X8@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_219245_1	102232.GLO73106DRAFT_00034980	2.474e-130	426.0	COG0082@1|root,COG0082@2|Bacteria,1G12S@1117|Cyanobacteria	1117|Cyanobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.aroC	Chorismate_synt
TLS3_k127_219245_3	1121904.ARBP01000042_gene4929	9.285e-24	113.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,47MZH@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_220056_1	665942.HMPREF1022_02166	5.213e-07	61.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2M8RM@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
TLS3_k127_220056_0	880073.Calab_2511	1.195e-62	226.0	COG0602@1|root,COG0602@2|Bacteria,2NPEM@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
TLS3_k127_2200708_1	426114.THI_1470	3.464e-55	202.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,1KPGZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
TLS3_k127_2200708_0	706587.Desti_4699	5.833e-71	248.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	exodeoxyribonuclease III	exoA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS3_k127_2204863_0	635013.TherJR_1781	2.473e-102	345.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,260I8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
TLS3_k127_2204863_1	1121468.AUBR01000016_gene2307	3.017e-49	187.0	COG0382@1|root,COG0382@2|Bacteria,1TQU5@1239|Firmicutes,2486B@186801|Clostridia,42F54@68295|Thermoanaerobacterales	186801|Clostridia	H	COGs COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS3_k127_2207274_0	1454004.AW11_01666	1.977e-144	472.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VH1N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_2207274_1	551275.KB899544_gene1735	4.505e-50	180.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,440QR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_221094_1	1048983.EL17_11400	4.406e-37	142.0	COG0599@1|root,COG0599@2|Bacteria,4NNPC@976|Bacteroidetes,47QDA@768503|Cytophagia	976|Bacteroidetes	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS3_k127_221094_0	1124780.ANNU01000008_gene2738	8.14e-109	362.0	COG0535@1|root,COG0535@2|Bacteria,4NFRX@976|Bacteroidetes,47KUF@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
TLS3_k127_221094_2	761193.Runsl_5373	8.19e-06	53.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2211857_0	661478.OP10G_0109	4.552e-08	64.0	COG1409@1|root,COG1520@1|root,COG1409@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	1.1.2.6,2.7.11.1,3.1.4.53	ko:K03651,ko:K05889,ko:K12132	ko00230,ko02025,map00230,map02025	-	R00191,R03136	RC00296	ko00000,ko00001,ko01000,ko01001	-	-	-	Cytochrome_CBB3,DUF1863,Metallophos,MetallophosN,PQQ,PQQ_2,PQQ_3
TLS3_k127_2213125_1	1121481.AUAS01000006_gene877	2.29e-38	162.0	COG1520@1|root,COG2931@1|root,COG5184@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,COG5184@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
TLS3_k127_2213125_0	889378.Spiaf_2002	7.709e-103	356.0	COG3604@1|root,COG3604@2|Bacteria,2J5TK@203691|Spirochaetes	203691|Spirochaetes	KT	Fis Family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
TLS3_k127_2213626_0	395493.BegalDRAFT_0259	3.403e-159	521.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,462C5@72273|Thiotrichales	72273|Thiotrichales	I	PFAM AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_221533_1	1121267.JHZL01000010_gene340	2.067e-08	60.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,42UBB@68525|delta/epsilon subdivisions,2YQEP@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_221533_0	1380391.JIAS01000019_gene1308	5.103e-40	154.0	COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,2JQ73@204441|Rhodospirillales	204441|Rhodospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS3_k127_2219946_0	502025.Hoch_6340	5.211e-23	107.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,42PK4@68525|delta/epsilon subdivisions,2WM1G@28221|Deltaproteobacteria,2YUAW@29|Myxococcales	28221|Deltaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS3_k127_222181_1	926561.KB900620_gene2912	1.169e-12	80.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TLS3_k127_222181_0	1140.Synpcc7942_0978	1.244e-32	132.0	COG0369@1|root,COG0369@2|Bacteria,1FZZF@1117|Cyanobacteria,1GZ1M@1129|Synechococcus	1117|Cyanobacteria	C	Ferredoxin--NADP reductase	petH	GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464	1.18.1.2	ko:K02641	ko00195,ko01100,map00195,map01100	-	-	-	ko00000,ko00001,ko00194,ko01000	-	-	iJN678.petH	CpcD,FAD_binding_6,NAD_binding_1
TLS3_k127_2224650_2	439235.Dalk_4424	1.349e-72	251.0	COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,42RXD@68525|delta/epsilon subdivisions,2WNCB@28221|Deltaproteobacteria,2MMC8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,Hydrolase_4
TLS3_k127_2224650_1	330214.NIDE1569	1.933e-115	386.0	COG1301@1|root,COG1301@2|Bacteria	2|Bacteria	C	dicarboxylic acid transport	-	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
TLS3_k127_2224650_3	397945.Aave_0668	1.464e-50	182.0	COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,2VRYP@28216|Betaproteobacteria,4AJEQ@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_2224650_0	525373.HMPREF0766_13282	7.399e-134	439.0	COG4990@1|root,COG4990@2|Bacteria,4NFZX@976|Bacteroidetes,1IPPX@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
TLS3_k127_2224755_0	760117.JN27_07135	5.306e-159	507.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2VHXM@28216|Betaproteobacteria,473M9@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_2224755_1	1303518.CCALI_02844	5.298e-140	460.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
TLS3_k127_2231026_3	644282.Deba_2187	2.245e-14	80.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42YI3@68525|delta/epsilon subdivisions,2WTI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_2231026_0	1123508.JH636439_gene1315	7.483e-75	280.0	COG4191@1|root,COG4191@2|Bacteria,2J2PC@203682|Planctomycetes	203682|Planctomycetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
TLS3_k127_2231026_5	1460640.JCM19046_4848	3.993e-07	59.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V4UB@1239|Firmicutes,4HDDC@91061|Bacilli,1ZCB2@1386|Bacillus	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
TLS3_k127_2231026_1	1168067.JAGP01000001_gene907	1.871e-69	258.0	COG2203@1|root,COG2206@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG4191@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF_2,HD,HD_5,PAS_4,PAS_9
TLS3_k127_2231026_6	1410609.JHVB01000005_gene1176	1.496e-05	58.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
TLS3_k127_2231026_4	1190603.AJYD01000025_gene450	1.286e-07	56.0	2C5D1@1|root,32YFH@2|Bacteria,1N97Z@1224|Proteobacteria,1SD06@1236|Gammaproteobacteria,1XZ2N@135623|Vibrionales	135623|Vibrionales	S	Tryptophan-rich protein (DUF2389)	VPA1560	-	-	-	-	-	-	-	-	-	-	-	DUF2389
TLS3_k127_2231026_2	313606.M23134_08300	8.022e-22	106.0	COG2114@1|root,COG2208@1|root,COG2114@2|Bacteria,COG2208@2|Bacteria,4NEVN@976|Bacteroidetes,47MR3@768503|Cytophagia	976|Bacteroidetes	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,Reg_prop,Response_reg,Y_Y_Y
TLS3_k127_2236136_2	1278073.MYSTI_03340	4.711e-29	117.0	COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria,1Q3Q7@1224|Proteobacteria,4342C@68525|delta/epsilon subdivisions,2X4TK@28221|Deltaproteobacteria,2YZJY@29|Myxococcales	28221|Deltaproteobacteria	T	PNKP adenylyltransferase domain, ligase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase
TLS3_k127_2236136_0	179408.Osc7112_2258	1.013e-164	531.0	COG2227@1|root,COG2227@2|Bacteria,1GQIM@1117|Cyanobacteria,1HE4C@1150|Oscillatoriales	1117|Cyanobacteria	H	RNA repair, ligase-Pnkp-associating, region of Hen1	-	-	-	-	-	-	-	-	-	-	-	-	Hen1_L,Methyltransf_12,Methyltransf_23
TLS3_k127_2236136_1	1254432.SCE1572_08850	7.816e-162	518.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2Z30G@29|Myxococcales	28221|Deltaproteobacteria	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
TLS3_k127_2239263_3	1349820.M707_14690	4.267e-12	76.0	COG0451@1|root,COG0451@2|Bacteria,2IF2Z@201174|Actinobacteria,1W9DZ@1268|Micrococcaceae	201174|Actinobacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
TLS3_k127_2239263_1	1089548.KI783301_gene1096	5.781e-59	223.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli,3WEEI@539002|Bacillales incertae sedis	91061|Bacilli	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_2239263_0	1168289.AJKI01000027_gene1349	1.557e-151	487.0	COG1088@1|root,COG1088@2|Bacteria,4NE9V@976|Bacteroidetes,2FMUH@200643|Bacteroidia,3XIPP@558415|Marinilabiliaceae	976|Bacteroidetes	M	Male sterility protein	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS3_k127_2239263_2	1121904.ARBP01000003_gene6589	7.06e-49	180.0	COG1091@1|root,COG1091@2|Bacteria,4NE3K@976|Bacteroidetes,47NQ1@768503|Cytophagia	976|Bacteroidetes	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS3_k127_2250802_0	316274.Haur_0985	2.362e-62	239.0	COG2204@1|root,COG5001@1|root,COG2204@2|Bacteria,COG5001@2|Bacteria,2G7UT@200795|Chloroflexi,3762V@32061|Chloroflexia	32061|Chloroflexia	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,Response_reg
TLS3_k127_2250802_1	1128421.JAGA01000002_gene1765	1.122e-29	124.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
TLS3_k127_2263442_0	907348.TresaDRAFT_0042	1.454e-57	207.0	COG1256@1|root,COG1256@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
TLS3_k127_226371_0	1234664.AMRO01000077_gene3432	1.863e-88	304.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,1WFX8@129337|Geobacillus	91061|Bacilli	S	Protein of unknown function (DUF1343)	ybbC	-	-	-	-	-	-	-	-	-	-	-	DUF1343
TLS3_k127_228926_1	927658.AJUM01000042_gene1607	2.354e-08	57.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,2FMI3@200643|Bacteroidia,3XITB@558415|Marinilabiliaceae	976|Bacteroidetes	Q	Mycolic acid cyclopropane synthetase	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS3_k127_228926_0	469616.FMAG_00399	9.027e-10	68.0	COG1306@1|root,COG1306@2|Bacteria,379EF@32066|Fusobacteria	32066|Fusobacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
TLS3_k127_2299213_1	1005395.CSV86_22111	1.042e-38	155.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RPVU@1236|Gammaproteobacteria,1YVUK@136845|Pseudomonas putida group	1236|Gammaproteobacteria	T	Histidine kinase	creC	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031667,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07641,ko:K07711	ko02020,ko02024,map02020,map02024	M00449,M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_3,sCache_3_2
TLS3_k127_2299213_0	391615.ABSJ01000039_gene1813	3.716e-64	227.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1S179@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	creB	-	-	ko:K07663	ko02020,map02020	M00449	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_2300633_1	472759.Nhal_0313	1.24e-105	355.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales	135613|Chromatiales	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS3_k127_2300633_5	1318628.MARLIPOL_07679	3.368e-10	71.0	2E5SG@1|root,330GY@2|Bacteria,1NB2M@1224|Proteobacteria,1SCUK@1236|Gammaproteobacteria,468X9@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2300633_3	264462.Bd3281	8.825e-58	217.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,42NJV@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	COG2211 Na melibiose symporter and related	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
TLS3_k127_2300633_4	555079.Toce_1087	1.265e-56	208.0	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,25C3N@186801|Clostridia,42G77@68295|Thermoanaerobacterales	186801|Clostridia	D	tyrosine recombinase XerC	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_2300633_2	1499967.BAYZ01000086_gene5173	1.001e-88	312.0	COG0612@1|root,COG0612@2|Bacteria,2NQPM@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_2300633_0	385682.AFSL01000008_gene2528	9.902e-107	354.0	COG2171@1|root,COG2171@2|Bacteria,4NEWD@976|Bacteroidetes,2FRBM@200643|Bacteroidia,3XJUR@558415|Marinilabiliaceae	976|Bacteroidetes	E	Tetrahydrodipicolinate N-succinyltransferase N-terminal	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
TLS3_k127_2304595_0	313606.M23134_08427	5.678e-54	204.0	COG0438@1|root,COG0438@2|Bacteria,4NJXT@976|Bacteroidetes,47N0S@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Sulfotransfer_1
TLS3_k127_230631_1	1121017.AUFG01000014_gene2032	4.235e-18	89.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4FETT@85021|Intrasporangiaceae	201174|Actinobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS3_k127_230631_0	1111479.AXAR01000008_gene2387	6.16e-45	171.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli,277VJ@186823|Alicyclobacillaceae	91061|Bacilli	O	Belongs to the ClpA ClpB family	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS3_k127_2316164_0	1385511.N783_18660	1.575e-56	207.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,2YBVV@289201|Pontibacillus	91061|Bacilli	U	Sugar ABC transporter permease	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_2316164_1	1476876.JOJO01000014_gene7278	1.193e-12	77.0	COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria	201174|Actinobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_2324790_1	83406.HDN1F_21870	1.58e-67	239.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,1RSN2@1236|Gammaproteobacteria,1J6PA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
TLS3_k127_2324790_0	1089552.KI911559_gene1455	5.824e-79	272.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,2JR7P@204441|Rhodospirillales	204441|Rhodospirillales	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS3_k127_2324790_2	305700.B447_05810	2.676e-08	57.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,2KUUF@206389|Rhodocyclales	206389|Rhodocyclales	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
TLS3_k127_2346388_0	1192034.CAP_7788	9.155e-10	70.0	COG1520@1|root,COG2234@1|root,COG1520@2|Bacteria,COG2234@2|Bacteria,1NI1E@1224|Proteobacteria,430IZ@68525|delta/epsilon subdivisions,2WW3C@28221|Deltaproteobacteria,2YZ85@29|Myxococcales	28221|Deltaproteobacteria	S	Dual-action HEIGH metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_M10,Peptidase_M57
TLS3_k127_2346941_1	509635.N824_04545	1.175e-10	72.0	COG1309@1|root,COG1309@2|Bacteria,4NPAQ@976|Bacteroidetes,1ISFU@117747|Sphingobacteriia	976|Bacteroidetes	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS3_k127_2346941_0	1121373.KB903638_gene904	1.064e-51	188.0	COG1398@1|root,COG1398@2|Bacteria,4NE0I@976|Bacteroidetes,47KJ0@768503|Cytophagia	976|Bacteroidetes	I	fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS3_k127_2353603_0	1177179.A11A3_01772	1.66e-126	420.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RR6H@1236|Gammaproteobacteria,1XJ4I@135619|Oceanospirillales	135619|Oceanospirillales	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
TLS3_k127_2353603_1	1121930.AQXG01000010_gene3037	6.128e-91	306.0	COG1137@1|root,COG1137@2|Bacteria,4NDUG@976|Bacteroidetes,1IQQ1@117747|Sphingobacteriia	976|Bacteroidetes	S	ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_2353603_2	1158607.UAU_00916	3.041e-06	56.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,4HA8T@91061|Bacilli,4B042@81852|Enterococcaceae	91061|Bacilli	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TLS3_k127_2361448_0	1192034.CAP_0386	8.882e-96	320.0	COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,439AV@68525|delta/epsilon subdivisions,2X4IJ@28221|Deltaproteobacteria,2YZ3A@29|Myxococcales	28221|Deltaproteobacteria	F	COG0208 Ribonucleotide reductase, beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2362158_1	1122925.KB895383_gene3390	5.043e-13	81.0	COG3325@1|root,COG3979@1|root,COG4733@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,COG4733@2|Bacteria,1UPJ7@1239|Firmicutes,4HBA7@91061|Bacilli,26SGN@186822|Paenibacillaceae	91061|Bacilli	G	chitinase	chiA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_2,CBM_5_12,Glyco_hydro_18,fn3
TLS3_k127_2362158_0	1211112.ALJC01000062_gene1700	8.28e-66	243.0	COG2374@1|root,COG2374@2|Bacteria,1N5TK@1224|Proteobacteria	1224|Proteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_2367009_0	1353529.M899_1119	1.736e-81	287.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
TLS3_k127_2367009_3	1122605.KB893646_gene45	1.21e-21	98.0	2AGY9@1|root,3176X@2|Bacteria,4NQD4@976|Bacteroidetes,1ISTG@117747|Sphingobacteriia	976|Bacteroidetes	S	TIGRFAM Gliding motility-associated protein, GldC	gldC	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2367009_1	1184267.A11Q_896	6.221e-67	244.0	COG2114@1|root,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,42Y3Q@68525|delta/epsilon subdivisions,2MTU8@213481|Bdellovibrionales,2WT53@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
TLS3_k127_2367009_5	557599.MKAN_01335	8.6e-09	61.0	COG2114@1|root,COG2114@2|Bacteria,2IEX3@201174|Actinobacteria,23CQN@1762|Mycobacteriaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS3_k127_2367009_2	452637.Oter_3178	3.014e-31	128.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia,3K801@414999|Opitutae	414999|Opitutae	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS3_k127_2376239_1	1245475.ANAE01000127_gene549	2.588e-14	80.0	COG0671@1|root,COG0671@2|Bacteria,2I92V@201174|Actinobacteria,4EKFK@85012|Streptosporangiales	201174|Actinobacteria	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS3_k127_2376239_0	517417.Cpar_1930	2.056e-35	145.0	COG1208@1|root,COG1208@2|Bacteria,1FDKD@1090|Chlorobi	1090|Chlorobi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS3_k127_2381514_0	1227739.Hsw_4268	5.533e-33	131.0	COG4270@1|root,COG4270@2|Bacteria,4NQAY@976|Bacteroidetes,47RIE@768503|Cytophagia	976|Bacteroidetes	S	COGs COG4270 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,DoxX_2
TLS3_k127_2381514_1	1123489.AUAN01000002_gene744	5.328e-31	123.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,4H4IP@909932|Negativicutes	909932|Negativicutes	G	isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TLS3_k127_2386330_0	203124.Tery_2249	3.981e-46	174.0	COG0566@1|root,COG0566@2|Bacteria,1G05W@1117|Cyanobacteria,1HAR0@1150|Oscillatoriales	1117|Cyanobacteria	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylas_C,SpoU_methylase
TLS3_k127_2386330_1	868864.Dester_1017	6.897e-28	113.0	COG0236@1|root,COG0236@2|Bacteria,2G491@200783|Aquificae	200783|Aquificae	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS3_k127_2399832_2	313606.M23134_06670	1.186e-51	186.0	COG2114@1|root,COG2114@2|Bacteria,4NEVN@976|Bacteroidetes,47MR3@768503|Cytophagia	976|Bacteroidetes	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_12,TPR_8
TLS3_k127_2399832_1	1123023.JIAI01000002_gene4673	6.781e-88	298.0	COG4221@1|root,COG4221@2|Bacteria,2GN3I@201174|Actinobacteria,4DZAC@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_2399832_0	383372.Rcas_3626	1.299e-96	330.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS3_k127_2401103_1	1121451.DESAM_21841	8.905e-10	65.0	COG2033@1|root,COG2033@2|Bacteria,1N615@1224|Proteobacteria,43605@68525|delta/epsilon subdivisions,2X0HN@28221|Deltaproteobacteria,2MCCM@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Desulfoferrodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Desulfoferrodox
TLS3_k127_2401103_0	1121324.CLIT_4c00050	4.446e-10	73.0	COG2247@1|root,COG2247@2|Bacteria	2|Bacteria	M	cell wall organization	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,SLH,SWM_repeat
TLS3_k127_2407052_1	56780.SYN_01550	0.0007	43.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MRN4@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
TLS3_k127_2407052_0	1242864.D187_003782	6.276e-157	512.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
TLS3_k127_240857_0	1088721.NSU_0641	1.052e-26	109.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,2K1ES@204457|Sphingomonadales	204457|Sphingomonadales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS3_k127_240857_1	118005.AWNK01000011_gene154	9.795e-18	89.0	COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria	2|Bacteria	T	EAL domain	yjcC	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,Peripla_BP_3
TLS3_k127_2410442_1	1157632.AQWQ01000001_gene5924	4.793e-22	113.0	COG2273@1|root,COG2273@2|Bacteria,2GJQP@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16,RicinB_lectin_2,Ricin_B_lectin
TLS3_k127_2410442_0	83406.HDN1F_08830	2.188e-146	494.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Alginate_lyase2,Cellulase,Chondroitinas_B,F5_F8_type_C,Glyco_hydro_16
TLS3_k127_2410848_1	506534.Rhein_0664	8.396e-44	170.0	COG2010@1|root,COG2010@2|Bacteria,1N9MS@1224|Proteobacteria,1T0TG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS3_k127_2410848_0	264732.Moth_1637	8.081e-61	223.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,42G1M@68295|Thermoanaerobacterales	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS3_k127_241285_0	251229.Chro_4923	1.648e-214	689.0	COG0642@1|root,COG0745@1|root,COG0840@1|root,COG2203@1|root,COG3437@1|root,COG0745@2|Bacteria,COG0840@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G13T@1117|Cyanobacteria,3VIPY@52604|Pleurocapsales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,Response_reg
TLS3_k127_241285_1	1173025.GEI7407_2018	5.559e-12	68.0	COG0784@1|root,COG2202@1|root,COG3437@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1G2MH@1117|Cyanobacteria,1H902@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
TLS3_k127_2416149_2	76114.p2D4	1.013e-23	105.0	COG3631@1|root,COG3631@2|Bacteria,1N5XE@1224|Proteobacteria,2VVP3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
TLS3_k127_2416149_3	717785.HYPMC_2528	1.033e-20	96.0	COG3315@1|root,COG3315@2|Bacteria,1RG18@1224|Proteobacteria,2VFMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
TLS3_k127_2416149_1	497964.CfE428DRAFT_1677	5.066e-31	125.0	COG3315@1|root,COG3315@2|Bacteria	2|Bacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
TLS3_k127_2416149_0	518766.Rmar_1330	4.183e-47	179.0	COG1262@1|root,COG1262@2|Bacteria,4NEUZ@976|Bacteroidetes	976|Bacteroidetes	KLT	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,Big_2,FGE-sulfatase
TLS3_k127_2420407_5	1179226.AJXO01000025_gene140	1.765e-07	61.0	COG1999@1|root,COG1999@2|Bacteria,1V4FW@1239|Firmicutes,4HHC4@91061|Bacilli,4GYXI@90964|Staphylococcaceae	91061|Bacilli	S	SCO1/SenC	ypmQ_1	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS3_k127_2420407_0	261292.Nit79A3_2374	3.998e-90	307.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS3_k127_2420407_3	279714.FuraDRAFT_2508	1.536e-35	143.0	COG4273@1|root,COG4273@2|Bacteria,1MZED@1224|Proteobacteria,2VV77@28216|Betaproteobacteria,2KTBJ@206351|Neisseriales	206351|Neisseriales	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
TLS3_k127_2420407_1	314345.SPV1_08381	1.35e-62	220.0	COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	yaeQ	-	-	-	-	-	-	-	-	-	-	-	YaeQ
TLS3_k127_2420407_4	1304872.JAGC01000009_gene84	2.187e-23	108.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2MB9P@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM Cyclic nucleotide-binding	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_2420407_2	583345.Mmol_1061	1.468e-59	210.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2VK95@28216|Betaproteobacteria,2KP4S@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3,Cytochrome_CBB3
TLS3_k127_2420480_0	1408224.SAMCCGM7_c0011	5.94e-10	66.0	COG1653@1|root,COG1653@2|Bacteria,1R69R@1224|Proteobacteria,2TTS8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_2420480_1	575788.VS_II0168	3.759e-09	68.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1XT7C@135623|Vibrionales	135623|Vibrionales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
TLS3_k127_2427305_0	756272.Plabr_2566	1.425e-18	88.0	COG0004@1|root,COG0004@2|Bacteria,2IXR9@203682|Planctomycetes	203682|Planctomycetes	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS3_k127_242909_2	391625.PPSIR1_19479	0.000394	49.0	COG0858@1|root,COG0858@2|Bacteria,1QAV6@1224|Proteobacteria,435BE@68525|delta/epsilon subdivisions,2WZNT@28221|Deltaproteobacteria,2Z2FN@29|Myxococcales	28221|Deltaproteobacteria	J	Ribosome-binding factor A	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_242909_1	1123242.JH636434_gene4539	6.1e-92	314.0	COG1690@1|root,COG1690@2|Bacteria,2IZTT@203682|Planctomycetes	203682|Planctomycetes	S	tRNA-splicing ligase RtcB	-	-	-	-	-	-	-	-	-	-	-	-	RtcB
TLS3_k127_242909_0	32057.KB217478_gene3884	9.2e-144	460.0	COG0714@1|root,COG0714@2|Bacteria,1GD74@1117|Cyanobacteria,1HQHU@1161|Nostocales	1117|Cyanobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS3_k127_2436414_1	179408.Osc7112_1555	5.653e-65	237.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG2770@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
TLS3_k127_2436414_0	765914.ThisiDRAFT_0499	8.364e-190	618.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Phosphonate-bd,Response_reg
TLS3_k127_2437802_2	938709.AUSH02000031_gene1339	6.462e-22	99.0	COG2391@1|root,COG2391@2|Bacteria,4NQ9C@976|Bacteroidetes	976|Bacteroidetes	S	Transporter	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TLS3_k127_2437802_1	1307761.L21SP2_3242	1.378e-23	106.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TLS3_k127_2437802_0	1123508.JH636446_gene6194	1.401e-191	608.0	COG0520@1|root,COG0520@2|Bacteria,2IX1C@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS3_k127_2439724_0	1341155.FSS13T_17060	8.978e-157	504.0	COG1858@1|root,COG1858@2|Bacteria,4NJGU@976|Bacteroidetes,1I0GT@117743|Flavobacteriia,2P00U@237|Flavobacterium	976|Bacteroidetes	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
TLS3_k127_2442697_2	1382358.JHVN01000016_gene570	4.605e-06	53.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1TQXC@1239|Firmicutes,4HCSG@91061|Bacilli,21WG2@150247|Anoxybacillus	91061|Bacilli	K	B12 binding domain	ycgE	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
TLS3_k127_2442697_0	756272.Plabr_2028	5.489e-112	371.0	COG2230@1|root,COG2230@2|Bacteria,2IY46@203682|Planctomycetes	203682|Planctomycetes	M	COG2230 Cyclopropane fatty acid synthase and related	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS3_k127_2442697_1	1233950.IW22_07180	2.506e-18	91.0	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1HYQF@117743|Flavobacteriia,3ZREM@59732|Chryseobacterium	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
TLS3_k127_2443795_1	1307761.L21SP2_1654	2.253e-25	116.0	28QN2@1|root,2ZD3Q@2|Bacteria,2JBB4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans
TLS3_k127_2443795_0	869210.Marky_1058	6.904e-94	312.0	COG1048@1|root,COG1048@2|Bacteria,1WIMG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acn	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS3_k127_2456451_1	1220534.B655_1999	1.126e-70	267.0	COG0642@1|root,COG0784@1|root,arCOG02348@1|root,arCOG02352@1|root,arCOG06712@1|root,arCOG02348@2157|Archaea,arCOG02352@2157|Archaea,arCOG02358@2157|Archaea,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
TLS3_k127_2456451_5	386456.JQKN01000005_gene466	7.315e-22	99.0	COG0784@1|root,arCOG06537@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_2456451_3	1206725.BAFU01000013_gene4041	5.473e-36	147.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,4FUFP@85025|Nocardiaceae	201174|Actinobacteria	J	SpoU rRNA Methylase family	spoU2	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
TLS3_k127_2456451_2	234267.Acid_4172	4.216e-55	199.0	COG3615@1|root,COG3615@2|Bacteria	2|Bacteria	P	Tellurite resistance protein tehB	tehB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.1.1.265	ko:K03647,ko:K16868	-	-	-	-	ko00000,ko01000	-	-	-	DUF1971,TehB
TLS3_k127_2456451_0	1288963.ADIS_3448	5.863e-95	320.0	COG0009@1|root,COG0009@2|Bacteria,4NF5U@976|Bacteroidetes,47KX9@768503|Cytophagia	976|Bacteroidetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS3_k127_2457791_0	335543.Sfum_1414	7.804e-73	251.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2MQ6J@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS3_k127_2463435_0	32057.KB217478_gene3883	6.076e-175	567.0	COG3864@1|root,COG3864@2|Bacteria,1GCCH@1117|Cyanobacteria,1HR8R@1161|Nostocales	1117|Cyanobacteria	S	Putative metallopeptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2201_N
TLS3_k127_2464589_0	190486.XAC3147	4.352e-73	253.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1X2XF@135614|Xanthomonadales	135614|Xanthomonadales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS3_k127_2467617_0	483219.LILAB_27955	0.0006886	53.0	COG2374@1|root,COG3568@1|root,COG2374@2|Bacteria,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	3.2.1.4	ko:K01179,ko:K07004	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Exo_endo_phos,Hint_2,LTD
TLS3_k127_2472564_0	1539298.JO41_12215	1.228e-140	480.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
TLS3_k127_247837_0	879212.DespoDRAFT_02546	1.762e-62	225.0	COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,42ZPX@68525|delta/epsilon subdivisions,2WV2B@28221|Deltaproteobacteria,2MND9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
TLS3_k127_2484280_0	378806.STAUR_4559	2.659e-08	62.0	COG4775@1|root,COG4775@2|Bacteria,1Q3G3@1224|Proteobacteria,4398B@68525|delta/epsilon subdivisions,2X4FH@28221|Deltaproteobacteria,2YYX7@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
TLS3_k127_2488873_0	523791.Kkor_1363	2.745e-14	76.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1XH64@135619|Oceanospirillales	135619|Oceanospirillales	L	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_2488873_1	313606.M23134_04296	2.482e-09	67.0	28J0S@1|root,2Z8XX@2|Bacteria,4P2J4@976|Bacteroidetes,47X8E@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2494054_0	1033837.WANG_0375	5.388e-21	96.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,4HIGK@91061|Bacilli,3F6WT@33958|Lactobacillaceae	91061|Bacilli	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS3_k127_2502840_3	714943.Mucpa_7008	8.603e-07	53.0	2CH44@1|root,32S57@2|Bacteria,4NZMQ@976|Bacteroidetes,1IY49@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2502840_1	450851.PHZ_c1818	5.241e-49	182.0	COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,2UBM6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	DSBA-like thioredoxin domain	-	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	DSBA,Thioredoxin_5
TLS3_k127_2502840_0	439235.Dalk_2037	3.574e-119	392.0	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,42NGH@68525|delta/epsilon subdivisions,2WKS6@28221|Deltaproteobacteria,2MI68@213118|Desulfobacterales	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase isomerase	-	-	1.1.1.394,1.1.1.412	ko:K21271,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD
TLS3_k127_2502840_2	96561.Dole_3200	1.044e-27	117.0	2DSXM@1|root,33HUR@2|Bacteria,1NKYR@1224|Proteobacteria,430HU@68525|delta/epsilon subdivisions,2WW10@28221|Deltaproteobacteria,2MNS7@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2508825_0	525903.Taci_0155	2.618e-12	78.0	COG1409@1|root,COG1409@2|Bacteria,3TBDZ@508458|Synergistetes	508458|Synergistetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS3_k127_2516796_1	1122609.AUGT01000002_gene3866	2.062e-05	57.0	COG0737@1|root,COG2373@1|root,COG2374@1|root,COG4257@1|root,COG0737@2|Bacteria,COG2373@2|Bacteria,COG2374@2|Bacteria,COG4257@2|Bacteria,2GKC3@201174|Actinobacteria,4DUQV@85009|Propionibacteriales	201174|Actinobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Big_3_5,Exo_endo_phos,LTD,Metallophos,PKD
TLS3_k127_2516796_0	608538.HTH_1822	1.605e-13	83.0	COG1502@1|root,COG1502@2|Bacteria,2G44G@200783|Aquificae	200783|Aquificae	I	SMART phospholipase D Transphosphatidylase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
TLS3_k127_2518347_1	485918.Cpin_1567	1.145e-79	275.0	28M67@1|root,2ZAJW@2|Bacteria,4NF2D@976|Bacteroidetes,1ISM2@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2518347_0	395493.BegalDRAFT_0012	2.838e-87	301.0	2DHAX@1|root,32U8Z@2|Bacteria	2|Bacteria	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DZR
TLS3_k127_2518347_2	491205.JARQ01000001_gene871	5.501e-12	69.0	28JIP@1|root,2Z82C@2|Bacteria,4NFN9@976|Bacteroidetes,1HZ0J@117743|Flavobacteriia,3ZQA2@59732|Chryseobacterium	976|Bacteroidetes	S	S1 P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
TLS3_k127_2519959_0	1313301.AUGC01000004_gene2334	2.045e-16	91.0	COG2208@1|root,COG2208@2|Bacteria,4NI98@976|Bacteroidetes	976|Bacteroidetes	KT	Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
TLS3_k127_2521960_1	1131269.AQVV01000003_gene675	4.079e-12	76.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2521960_0	1415755.JQLV01000002_gene620	2.653e-31	130.0	COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,1RNQH@1236|Gammaproteobacteria,1XM5H@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
TLS3_k127_2521960_2	1333507.AUTQ01000069_gene2156	0.0003758	51.0	COG5184@1|root,COG5184@2|Bacteria,1R0KM@1224|Proteobacteria,1T4JW@1236|Gammaproteobacteria,2Q1PE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	DZ	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	LTD
TLS3_k127_2527416_0	1408444.JHYC01000007_gene2181	4.197e-26	118.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1JDX7@118969|Legionellales	118969|Legionellales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS3_k127_2527416_1	661478.OP10G_2171	2.544e-11	70.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS3_k127_2534022_0	665571.STHERM_c14800	3.945e-13	82.0	2FFB7@1|root,3478X@2|Bacteria,2J8CB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2537553_0	665571.STHERM_c12630	4.432e-17	94.0	COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
TLS3_k127_2537553_1	1156919.QWC_29933	0.0008962	48.0	COG0457@1|root,COG0457@2|Bacteria	1156919.QWC_29933|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2541283_1	234267.Acid_5328	3.101e-24	110.0	COG0392@1|root,COG0392@2|Bacteria,3Y78T@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS3_k127_2541283_2	984262.SGRA_2889	2.08e-08	64.0	COG2885@1|root,COG2885@2|Bacteria,4NKCW@976|Bacteroidetes	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS3_k127_2541283_0	1173024.KI912148_gene3913	1.953e-44	163.0	COG2321@1|root,COG2321@2|Bacteria,1G20J@1117|Cyanobacteria	1117|Cyanobacteria	S	neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS3_k127_254723_1	264462.Bd1145	7.921e-08	57.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2MTPM@213481|Bdellovibrionales,2WJVV@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	Hydrophobe amphiphile Efflux-1 (HAE1) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS3_k127_254723_0	439235.Dalk_4478	2.712e-86	306.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,2MISX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS3_k127_2547682_0	665952.HMPREF1015_01834	9.714e-197	626.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,1ZB8F@1386|Bacillus	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS3_k127_2550391_0	1129374.AJE_17054	3.343e-130	417.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,465HN@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnD	GO:0003674,GO:0003824,GO:0003994,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:1901575	4.2.1.117,4.2.1.3	ko:K01681,ko:K20455	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900,R11263	RC00497,RC00498,RC00618,RC01152	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS3_k127_2550391_1	1127673.GLIP_3140	1.571e-95	317.0	COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,1RYXQ@1236|Gammaproteobacteria,466TS@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	COG1802 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_2550391_2	565045.NOR51B_1342	6.104e-12	74.0	COG2010@1|root,COG2374@1|root,COG3391@1|root,COG2010@2|Bacteria,COG2374@2|Bacteria,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria	1224|Proteobacteria	M	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
TLS3_k127_2557139_2	1028801.RG1141_CH19990	5.174e-11	73.0	COG0515@1|root,COG0515@2|Bacteria,1P7KE@1224|Proteobacteria,2UXQG@28211|Alphaproteobacteria,4BEZB@82115|Rhizobiaceae	28211|Alphaproteobacteria	KLT	Domain of unknown function (DUF4189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4189
TLS3_k127_2557139_0	1121456.ATVA01000011_gene1534	2.349e-32	126.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria,2MCF7@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS3_k127_2557139_1	1002672.SAR11G3_00761	3.683e-22	104.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,4BP57@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_256437_2	1121889.AUDM01000011_gene2783	4.892e-05	54.0	COG0296@1|root,COG0296@2|Bacteria,4NSTP@976|Bacteroidetes,1I4C7@117743|Flavobacteriia,2NWNY@237|Flavobacterium	976|Bacteroidetes	G	glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
TLS3_k127_256437_1	1125863.JAFN01000001_gene972	1.008e-23	109.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42T2J@68525|delta/epsilon subdivisions,2WPPV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
TLS3_k127_256437_0	870187.Thini_1389	6.762e-28	123.0	2E0CA@1|root,32VZA@2|Bacteria,1N2VB@1224|Proteobacteria,1SEKH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2565798_1	700598.Niako_0459	2.339e-170	538.0	COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IV6M@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
TLS3_k127_2565798_0	378806.STAUR_8042	3.056e-237	739.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42PXH@68525|delta/epsilon subdivisions,2WKEX@28221|Deltaproteobacteria,2YTWX@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
TLS3_k127_2565798_2	1484460.JSWG01000015_gene1185	1.351e-104	350.0	COG1953@1|root,COG1953@2|Bacteria,4NFK3@976|Bacteroidetes	976|Bacteroidetes	FH	PFAM Permease for cytosine purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
TLS3_k127_2570969_2	391600.ABRU01000043_gene2696	2.839e-12	78.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2KGH4@204458|Caulobacterales	204458|Caulobacterales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS3_k127_2570969_1	580340.Tlie_0581	3.515e-55	208.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,3T9T4@508458|Synergistetes	508458|Synergistetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
TLS3_k127_2570969_0	1051632.TPY_3670	5.531e-75	267.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,3WD4K@538999|Clostridiales incertae sedis	186801|Clostridia	M	DegT/DnrJ/EryC1/StrS aminotransferase family	spsC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS3_k127_2570969_3	649639.Bcell_2473	1.263e-08	64.0	COG1315@1|root,COG1315@2|Bacteria,1TR7W@1239|Firmicutes,4H9TJ@91061|Bacilli,1ZC1A@1386|Bacillus	91061|Bacilli	L	Flagellar Assembly Protein A	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
TLS3_k127_2582037_1	1121904.ARBP01000010_gene2383	2.172e-136	445.0	COG1251@1|root,COG1251@2|Bacteria,4NE44@976|Bacteroidetes,47M7X@768503|Cytophagia	976|Bacteroidetes	C	Nitrite and sulphite reductase 4Fe-4S	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
TLS3_k127_2582037_0	224308.BSU03330	9.247e-137	448.0	COG2223@1|root,COG2223@2|Bacteria,1TRS9@1239|Firmicutes,4HCY1@91061|Bacilli,1ZBQH@1386|Bacillus	91061|Bacilli	P	COG2223 Nitrate nitrite transporter	nasA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	iYO844.BSU03330	MFS_1
TLS3_k127_2582037_2	1382359.JIAL01000001_gene3013	1.517e-56	201.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,3Y5RE@57723|Acidobacteria,2JKSV@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	DmsC,Fer4_11
TLS3_k127_2590508_3	877424.ATWC01000018_gene1093	4.061e-05	51.0	COG1396@1|root,COG1396@2|Bacteria,1VA98@1239|Firmicutes,24A4S@186801|Clostridia,27M1R@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS3_k127_2590508_0	1340493.JNIF01000003_gene2060	6.355e-129	445.0	COG0358@1|root,COG0358@2|Bacteria	2|Bacteria	L	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,Toprim_N,zf-CHC2
TLS3_k127_2590508_1	195250.CM001776_gene952	1.366e-54	215.0	COG4974@1|root,COG4974@2|Bacteria,1G4JW@1117|Cyanobacteria,1GZF3@1129|Synechococcus	1117|Cyanobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS3_k127_2590508_2	267608.RSp0090	2.84e-45	186.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,1K1BK@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Tyrosine recombinase XerD	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_2595275_0	1122951.ATUE01000009_gene381	1.885e-61	219.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,1S0NB@1236|Gammaproteobacteria,3NKCP@468|Moraxellaceae	1236|Gammaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_2595275_1	1034347.CAHJ01000011_gene2279	1.807e-07	55.0	COG2200@1|root,COG2200@2|Bacteria,1UADD@1239|Firmicutes,4HCNX@91061|Bacilli,1ZBWD@1386|Bacillus	91061|Bacilli	T	Diguanylate phosphodiesterase	ykuI	-	-	-	-	-	-	-	-	-	-	-	EAL,YkuI_C
TLS3_k127_2597829_0	889378.Spiaf_1914	1.783e-47	183.0	COG5009@1|root,COG5009@2|Bacteria,2J5D4@203691|Spirochaetes	203691|Spirochaetes	M	penicillin-binding protein	pbp-3	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS3_k127_2603392_0	1123368.AUIS01000028_gene1326	1.441e-63	231.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_2603392_1	717785.HYPMC_3231	1.89e-44	172.0	COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
TLS3_k127_2617547_1	946077.W5A_04908	0.0001006	46.0	COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,1HYPM@117743|Flavobacteriia	976|Bacteroidetes	L	Tyrosine recombinase XerC	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_2617547_0	1267535.KB906767_gene2312	1.101e-38	160.0	COG1524@1|root,COG1524@2|Bacteria,3Y7AY@57723|Acidobacteria,2JKSW@204432|Acidobacteriia	204432|Acidobacteriia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS3_k127_2625845_0	1125863.JAFN01000001_gene1788	1.577e-105	349.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1360	Ldh_1_C,Ldh_1_N
TLS3_k127_2642938_0	1254432.SCE1572_06975	8.382e-226	707.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42P3K@68525|delta/epsilon subdivisions,2WMB8@28221|Deltaproteobacteria,2YWYR@29|Myxococcales	28221|Deltaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS3_k127_2642938_4	1123054.KB907724_gene2811	6.351e-06	53.0	2EID4@1|root,33C4H@2|Bacteria,1NINC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2642938_3	292459.STH845	4.378e-22	103.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_2642938_2	378806.STAUR_3629	2.045e-52	199.0	COG1597@1|root,COG1597@2|Bacteria,1Q2E6@1224|Proteobacteria,437ZZ@68525|delta/epsilon subdivisions,2X9TP@28221|Deltaproteobacteria,2YV1J@29|Myxococcales	28221|Deltaproteobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS3_k127_2642938_1	1033802.SSPSH_001775	2.428e-142	464.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_3
TLS3_k127_2647971_1	903818.KI912269_gene491	1.788e-17	82.0	COG0438@1|root,COG0438@2|Bacteria,3Y68X@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_2647971_0	1396418.BATQ01000133_gene4014	1.47e-176	562.0	COG2152@1|root,COG2152@2|Bacteria,46S8T@74201|Verrucomicrobia,2IUQX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
TLS3_k127_2647971_2	552811.Dehly_0458	5.718e-12	66.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_2653334_1	1122927.KB895416_gene3544	1.941e-89	304.0	COG2271@1|root,COG2271@2|Bacteria,1UNX4@1239|Firmicutes,4IUTN@91061|Bacilli,26YVJ@186822|Paenibacillaceae	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_2653334_3	755178.Cyan10605_2668	4.03e-39	150.0	COG3577@1|root,COG3577@2|Bacteria,1G6TW@1117|Cyanobacteria	1117|Cyanobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
TLS3_k127_2653334_4	1380390.JIAT01000010_gene3850	3.652e-16	93.0	COG2114@1|root,COG2114@2|Bacteria,2HSA4@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	cya	GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_2653334_0	247490.KSU1_C1278	1.308e-138	452.0	COG0527@1|root,COG0527@2|Bacteria,2IY8N@203682|Planctomycetes	203682|Planctomycetes	E	aspartate kinase, monofunctional class	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS3_k127_2653334_2	1151292.QEW_4196	1.249e-67	240.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,25R3M@186804|Peptostreptococcaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS3_k127_265552_2	1166948.JPZL01000001_gene3048	9.106e-05	46.0	COG1385@1|root,COG1385@2|Bacteria,1MZBG@1224|Proteobacteria,1S0HM@1236|Gammaproteobacteria,1XJ5U@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	-	-	-	-	-	-	-	-	-	-	Methyltrans_RNA
TLS3_k127_265552_1	685035.ADAE01000005_gene2012	8.987e-10	62.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
TLS3_k127_265552_0	316067.Geob_3016	6.493e-77	264.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,43T75@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS3_k127_2657045_4	1267211.KI669560_gene1897	2.044e-10	66.0	COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,4PP2V@976|Bacteroidetes	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,Response_reg
TLS3_k127_2657045_1	269798.CHU_2078	7.399e-52	189.0	COG2201@1|root,COG2201@2|Bacteria,4NNR3@976|Bacteroidetes,47PAB@768503|Cytophagia	976|Bacteroidetes	NT	CheB methylesterase	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS3_k127_2657045_0	1121373.KB903666_gene1368	1.526e-107	356.0	COG1352@1|root,COG1352@2|Bacteria,4NFDS@976|Bacteroidetes,47JV5@768503|Cytophagia	976|Bacteroidetes	NT	PFAM MCP methyltransferase CheR-type	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
TLS3_k127_2657045_2	1123508.JH636446_gene6359	2.808e-41	158.0	COG0784@1|root,COG0784@2|Bacteria,2J0TI@203682|Planctomycetes	203682|Planctomycetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_2657045_3	1173027.Mic7113_5684	6.005e-36	144.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1G48R@1117|Cyanobacteria	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS3_k127_2659865_1	1033802.SSPSH_001314	8.192e-62	223.0	COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,1RS01@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_2659865_2	391615.ABSJ01000005_gene564	1.473e-22	102.0	COG3832@1|root,COG3832@2|Bacteria,1N41H@1224|Proteobacteria,1T44H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_2659865_0	273121.WS2124	6.082e-229	715.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS3_k127_2662039_2	502025.Hoch_4648	1.351e-24	109.0	COG0811@1|root,COG0811@2|Bacteria,1NBED@1224|Proteobacteria,43BH4@68525|delta/epsilon subdivisions,2WRU4@28221|Deltaproteobacteria,2YVB3@29|Myxococcales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TLS3_k127_2662039_3	289376.THEYE_A0958	7.677e-15	79.0	COG0848@1|root,COG0848@2|Bacteria,3J0T6@40117|Nitrospirae	40117|Nitrospirae	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
TLS3_k127_2662039_4	483219.LILAB_14120	1.566e-07	62.0	COG0810@1|root,COG0810@2|Bacteria,1NFMG@1224|Proteobacteria,42UAW@68525|delta/epsilon subdivisions,2WTBZ@28221|Deltaproteobacteria,2Z1UD@29|Myxococcales	28221|Deltaproteobacteria	M	Ferric siderophore transporter, periplasmic energy transduction protein TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS3_k127_2662039_0	517418.Ctha_1737	7.333e-136	469.0	COG1629@1|root,COG4771@2|Bacteria,1FEFM@1090|Chlorobi	1090|Chlorobi	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
TLS3_k127_2662039_1	1220535.IMCC14465_06040	6.475e-30	128.0	COG2182@1|root,COG2182@2|Bacteria,1MU3H@1224|Proteobacteria,2U0ZI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2663564_1	1121456.ATVA01000018_gene358	1.319e-33	135.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128,2.3.1.183	ko:K03789,ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS3_k127_2663564_0	1233950.IW22_22400	1.23e-37	152.0	COG0705@1|root,COG0705@2|Bacteria,4NP9G@976|Bacteroidetes,1I9DW@117743|Flavobacteriia	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
TLS3_k127_2671997_1	1334046.AYTB01000021_gene684	2.382e-05	51.0	COG3584@1|root,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,4HC79@91061|Bacilli,26I8X@186818|Planococcaceae	91061|Bacilli	S	3D domain	yabE	-	-	ko:K02424	ko02010,map02010	M00234	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3.10,3.A.1.3.14	-	-	3D,SH3_3
TLS3_k127_2671997_0	1198232.CYCME_0381	4.412e-44	168.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,461AS@72273|Thiotrichales	72273|Thiotrichales	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
TLS3_k127_2676447_0	1539298.JO41_09035	7.133e-81	286.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
TLS3_k127_2681087_0	700598.Niako_1436	2.989e-198	626.0	COG0038@1|root,COG0038@2|Bacteria,4NEIA@976|Bacteroidetes,1IP55@117747|Sphingobacteriia	976|Bacteroidetes	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
TLS3_k127_2681087_2	525257.HMPREF0204_15210	1.14e-31	127.0	COG1993@1|root,COG1993@2|Bacteria	2|Bacteria	T	acr, cog1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
TLS3_k127_2681087_1	1121373.KB903654_gene1581	1.751e-45	168.0	COG2510@1|root,COG2510@2|Bacteria,4NQ4N@976|Bacteroidetes,47UX3@768503|Cytophagia	976|Bacteroidetes	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
TLS3_k127_2681087_3	290397.Adeh_3794	7.928e-13	76.0	COG2771@1|root,COG2771@2|Bacteria,1QU5E@1224|Proteobacteria,4319G@68525|delta/epsilon subdivisions,2WWCU@28221|Deltaproteobacteria,2Z1AC@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS3_k127_2683607_0	1313421.JHBV01000042_gene3327	3.395e-69	244.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS3_k127_2685723_1	323850.Shew_3328	1.025e-38	166.0	COG3055@1|root,COG3055@2|Bacteria,1NCP4@1224|Proteobacteria	1224|Proteobacteria	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2685723_0	518766.Rmar_2757	3.873e-193	623.0	COG0445@1|root,COG0445@2|Bacteria,4NFNH@976|Bacteroidetes,1FIT2@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
TLS3_k127_2685723_2	1504823.CCMM01000009_gene1114	2.346e-06	54.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	spoIIAA	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
TLS3_k127_2686126_0	1298593.TOL_2656	1.862e-34	138.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1XJUJ@135619|Oceanospirillales	135619|Oceanospirillales	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
TLS3_k127_2692588_1	83406.HDN1F_08830	4.221e-31	132.0	COG2730@1|root,COG2730@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Alginate_lyase2,Cellulase,Chondroitinas_B,F5_F8_type_C,Glyco_hydro_16
TLS3_k127_2692588_3	1035193.HMPREF9073_00742	6.422e-17	93.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZK0@117743|Flavobacteriia,1EQBM@1016|Capnocytophaga	976|Bacteroidetes	K	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_2692588_0	765911.Thivi_0746	2e-143	464.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1WW13@135613|Chromatiales	135613|Chromatiales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS3_k127_2692588_2	1382356.JQMP01000004_gene240	3.002e-27	118.0	COG1131@1|root,COG1131@2|Bacteria,2G6IS@200795|Chloroflexi,27YFZ@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
TLS3_k127_269524_1	335543.Sfum_1032	1.898e-72	254.0	COG0501@1|root,COG0501@2|Bacteria,1NA37@1224|Proteobacteria,42Y90@68525|delta/epsilon subdivisions,2WUAP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS3_k127_269524_0	382464.ABSI01000013_gene1716	1.09e-93	317.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_2695990_2	639282.DEFDS_0224	6.465e-10	69.0	COG0457@1|root,COG0457@2|Bacteria,2GG73@200930|Deferribacteres	200930|Deferribacteres	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
TLS3_k127_2695990_1	638303.Thal_1479	2.207e-39	161.0	COG0109@1|root,COG0109@2|Bacteria	2|Bacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	iSB619.SA_RS05465,iSFxv_1172.SFxv_0410,iYO844.BSU12080	UbiA
TLS3_k127_2695990_0	273068.TTE0604	3.418e-142	476.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,42EUR@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_2696579_3	1313172.YM304_42200	5.708e-10	62.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4CP5I@84992|Acidimicrobiia	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_2696579_2	313624.NSP_51880	5.249e-17	82.0	COG2336@1|root,COG2336@2|Bacteria,1G908@1117|Cyanobacteria,1HPIM@1161|Nostocales	1117|Cyanobacteria	T	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
TLS3_k127_2696579_1	278963.ATWD01000001_gene2995	8.78e-39	148.0	COG3654@1|root,COG3654@2|Bacteria,3Y5NN@57723|Acidobacteria,2JJXW@204432|Acidobacteriia	204432|Acidobacteriia	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
TLS3_k127_2696579_0	290318.Cvib_1648	8.113e-39	156.0	COG3178@1|root,COG3178@2|Bacteria,1FEBN@1090|Chlorobi	1090|Chlorobi	S	PFAM aminoglycoside phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
TLS3_k127_270785_0	748658.KB907315_gene2623	1.607e-27	119.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WWDP@135613|Chromatiales	135613|Chromatiales	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
TLS3_k127_270785_1	1121930.AQXG01000004_gene2981	1.109e-25	114.0	COG1109@1|root,COG1109@2|Bacteria,4NG3H@976|Bacteroidetes,1IP3X@117747|Sphingobacteriia	976|Bacteroidetes	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	glmM	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_2716271_0	314230.DSM3645_20072	1.765e-60	212.0	COG0056@1|root,COG0056@2|Bacteria,2IXN5@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS3_k127_2716271_5	63737.Npun_F4862	3.048e-07	60.0	COG0712@1|root,COG0712@2|Bacteria,1G5SS@1117|Cyanobacteria,1HJRK@1161|Nostocales	1117|Cyanobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
TLS3_k127_2716271_2	759914.BP951000_0566	8.882e-30	124.0	COG0711@1|root,COG0711@2|Bacteria,2J9EE@203691|Spirochaetes	203691|Spirochaetes	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS3_k127_2716271_4	706436.HMPREF9074_07224	6.063e-16	81.0	COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,1I53G@117743|Flavobacteriia,1ESEB@1016|Capnocytophaga	976|Bacteroidetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS3_k127_2716271_1	1191523.MROS_0276	2.01e-48	188.0	COG0356@1|root,COG0356@2|Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS3_k127_2716271_3	1121428.DESHY_160178___1	4.455e-28	116.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TQ94@1239|Firmicutes,248BK@186801|Clostridia,260U0@186807|Peptococcaceae	186801|Clostridia	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
TLS3_k127_2719180_1	1379281.AVAG01000087_gene708	5.01e-31	124.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2MCH7@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
TLS3_k127_2719180_0	401526.TcarDRAFT_0384	1.503e-220	696.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,4H29X@909932|Negativicutes	909932|Negativicutes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS3_k127_2719180_2	243231.GSU3016	1.255e-20	108.0	COG0823@1|root,COG2885@1|root,COG3291@1|root,COG4412@1|root,COG5492@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,COG5492@2|Bacteria,1PMFY@1224|Proteobacteria,42Y8D@68525|delta/epsilon subdivisions,2WUNZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
TLS3_k127_2728642_1	56780.SYN_01259	2.339e-51	187.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,42QRQ@68525|delta/epsilon subdivisions,2WMRU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	TIGRFAM methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
TLS3_k127_2728642_0	1499967.BAYZ01000079_gene882	3.915e-151	486.0	COG2021@1|root,COG2021@2|Bacteria,2NNZR@2323|unclassified Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS3_k127_2728642_2	1125700.HMPREF9195_01937	2.973e-11	67.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_2735444_2	1184267.A11Q_1379	2.416e-29	121.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,42M34@68525|delta/epsilon subdivisions,2MSKZ@213481|Bdellovibrionales,2WKJ6@28221|Deltaproteobacteria	213481|Bdellovibrionales	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS3_k127_2735444_3	869209.Tresu_1628	5.906e-05	52.0	COG1314@1|root,COG1314@2|Bacteria,2J7UR@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS3_k127_2735444_1	1034807.FBFL15_0976	6.272e-37	145.0	COG1765@1|root,COG1765@2|Bacteria,4NQHC@976|Bacteroidetes,1I2YM@117743|Flavobacteriia,2NW47@237|Flavobacterium	976|Bacteroidetes	O	redox protein, regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
TLS3_k127_2735444_0	269798.CHU_2639	6.198e-173	550.0	COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,47XY7@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	2.5.1.49	ko:K01740,ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01287,R01288,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_2742838_1	1121396.KB893112_gene1971	3.958e-18	96.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MIEH@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
TLS3_k127_2742838_0	316067.Geob_0774	3.818e-99	347.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TGP@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
TLS3_k127_2748345_3	1120792.JAFV01000001_gene2092	3.014e-06	53.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,36Z01@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
TLS3_k127_2748345_0	1207063.P24_18239	9.708e-20	100.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,2JWRS@204441|Rhodospirillales	204441|Rhodospirillales	S	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems	-	-	-	-	-	-	-	-	-	-	-	-	SCO1-SenC
TLS3_k127_2748345_1	562981.HMPREF0428_00252	2.927e-15	80.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,3WESX@539002|Bacillales incertae sedis	91061|Bacilli	C	SUF system FeS assembly protein, NifU family	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS3_k127_2748345_2	449447.MAE_00230	1.836e-11	68.0	COG0322@1|root,COG0322@2|Bacteria,1G0NS@1117|Cyanobacteria	1117|Cyanobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS3_k127_2756135_0	748280.NH8B_0688	1.611e-187	614.0	COG1203@1|root,COG1203@2|Bacteria,1MX99@1224|Proteobacteria,2VN60@28216|Betaproteobacteria,2KT0H@206351|Neisseriales	206351|Neisseriales	L	DEAD-like helicases superfamily	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
TLS3_k127_2757391_0	404380.Gbem_2063	1.012e-43	185.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS3_k127_275890_0	204536.SULAZ_0214	1.315e-49	186.0	COG0809@1|root,COG0809@2|Bacteria,2G3KG@200783|Aquificae	200783|Aquificae	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS3_k127_2776967_0	335543.Sfum_2246	0.0	1067.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
TLS3_k127_2776967_1	1504672.669782768	6.538e-144	473.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,4ADN0@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS3_k127_2776967_2	388467.A19Y_1273	2.773e-19	102.0	COG2202@1|root,COG2203@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,1H8X5@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
TLS3_k127_2781914_1	1245471.PCA10_18610	5.347e-32	129.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S94R@1236|Gammaproteobacteria,1YGCJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_2781914_2	1286632.P278_00790	2.637e-27	117.0	COG3070@1|root,COG3070@2|Bacteria,4NSGZ@976|Bacteroidetes,1I4CE@117743|Flavobacteriia	976|Bacteroidetes	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
TLS3_k127_2781914_4	1121889.AUDM01000046_gene224	8.338e-06	49.0	COG1595@1|root,COG1595@2|Bacteria,4NMAE@976|Bacteroidetes,1I1S3@117743|Flavobacteriia	976|Bacteroidetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS3_k127_2781914_0	1123326.JFBL01000013_gene317	1.319e-81	287.0	COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,42MIH@68525|delta/epsilon subdivisions,2YRAS@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,HDOD
TLS3_k127_2781914_3	1125725.HMPREF1325_1183	4.086e-08	60.0	COG0745@1|root,COG0745@2|Bacteria,2J7CF@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_2792459_1	96561.Dole_0986	8.188e-102	351.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
TLS3_k127_2792459_0	436717.AOLE_02965	3.908e-132	433.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RV50@1236|Gammaproteobacteria,3NJER@468|Moraxellaceae	1236|Gammaproteobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_2814348_0	95619.PM1_0215415	9.825e-50	181.0	COG0596@1|root,COG0596@2|Bacteria,1QIT9@1224|Proteobacteria,1RNP9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_2814348_1	1202962.KB907150_gene1955	1.009e-33	139.0	2DP10@1|root,3302V@2|Bacteria,1N246@1224|Proteobacteria,1S9RV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	START domain	-	-	-	-	-	-	-	-	-	-	-	-	START
TLS3_k127_2820101_1	1245469.S58_26790	4.787e-66	239.0	COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,3JTX3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Retinal pigment epithelial membrane protein	MA20_08640	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
TLS3_k127_2820101_0	626887.J057_00375	5.074e-171	544.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,4656A@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
TLS3_k127_2823777_0	1125699.HMPREF9194_00550	1.079e-69	245.0	COG3391@1|root,COG3391@2|Bacteria,2J5ZD@203691|Spirochaetes	203691|Spirochaetes	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_2824063_1	349741.Amuc_0682	3.219e-10	67.0	COG2885@1|root,COG2885@2|Bacteria,46ZBB@74201|Verrucomicrobia,2IU9R@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS3_k127_2824063_2	1279017.AQYJ01000022_gene2707	3.247e-10	66.0	COG1607@1|root,COG1607@2|Bacteria,1N13R@1224|Proteobacteria,1S956@1236|Gammaproteobacteria,466SK@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_2824063_0	639282.DEFDS_0235	5.167e-190	606.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GF76@200930|Deferribacteres	200930|Deferribacteres	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_2854327_0	1158318.ATXC01000001_gene421	8.283e-108	363.0	COG4992@1|root,COG4992@2|Bacteria,2G3V4@200783|Aquificae	200783|Aquificae	E	acetylornithine and succinylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_2857668_0	478741.JAFS01000002_gene62	5.477e-200	643.0	COG0855@1|root,COG0855@2|Bacteria,46SB4@74201|Verrucomicrobia,37GEJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS3_k127_2857668_1	373994.Riv7116_2845	8.669e-16	83.0	COG3670@1|root,COG3670@2|Bacteria,1G16F@1117|Cyanobacteria,1HJ72@1161|Nostocales	1117|Cyanobacteria	Q	PFAM Retinal pigment epithelial membrane protein	-	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
TLS3_k127_2879262_1	192875.XP_004348417.1	8.357e-09	67.0	COG0664@1|root,KOG1113@2759|Eukaryota,38GS1@33154|Opisthokonta	33154|Opisthokonta	T	Camp-dependent protein kinase	PRKAR1A	GO:0000003,GO:0000166,GO:0000226,GO:0000280,GO:0001704,GO:0001707,GO:0001932,GO:0001933,GO:0001934,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003006,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0005952,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006469,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007049,GO:0007143,GO:0007154,GO:0007162,GO:0007163,GO:0007165,GO:0007267,GO:0007268,GO:0007274,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007369,GO:0007389,GO:0007498,GO:0007507,GO:0007591,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007635,GO:0008103,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008306,GO:0008355,GO:0008603,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009798,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010639,GO:0010646,GO:0010648,GO:0010721,GO:0010927,GO:0010948,GO:0014706,GO:0014855,GO:0016020,GO:0016043,GO:0016310,GO:0016325,GO:0017076,GO:0019207,GO:0019210,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019932,GO:0019933,GO:0019935,GO:0019953,GO:0021700,GO:0022402,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023057,GO:0030029,GO:0030036,GO:0030104,GO:0030154,GO:0030155,GO:0030234,GO:0030239,GO:0030291,GO:0030551,GO:0030552,GO:0030554,GO:0030951,GO:0030952,GO:0031032,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031594,GO:0031625,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032878,GO:0032944,GO:0032945,GO:0032989,GO:0032991,GO:0033002,GO:0033043,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035265,GO:0035556,GO:0036094,GO:0036211,GO:0040007,GO:0040020,GO:0042048,GO:0042060,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042303,GO:0042325,GO:0042326,GO:0042327,GO:0042493,GO:0042592,GO:0042692,GO:0042802,GO:0042995,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043412,GO:0043434,GO:0043549,GO:0043900,GO:0043901,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044441,GO:0044444,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044853,GO:0045121,GO:0045202,GO:0045214,GO:0045471,GO:0045595,GO:0045596,GO:0045786,GO:0045835,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046006,GO:0046007,GO:0046677,GO:0048285,GO:0048332,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050670,GO:0050672,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050817,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051321,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051447,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0055001,GO:0055002,GO:0055017,GO:0060038,GO:0060255,GO:0060259,GO:0060281,GO:0060283,GO:0060284,GO:0060419,GO:0060537,GO:0061061,GO:0061695,GO:0065007,GO:0065008,GO:0065009,GO:0070663,GO:0070664,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072359,GO:0072375,GO:0080090,GO:0090036,GO:0090038,GO:0097159,GO:0097305,GO:0097367,GO:0097435,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0098916,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:0140013,GO:1900193,GO:1900194,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902532,GO:1902911,GO:1903037,GO:1903038,GO:1903046,GO:1903429,GO:1903430,GO:1903506,GO:1903538,GO:1905879,GO:1905880,GO:1990234,GO:2000112,GO:2000114,GO:2000241,GO:2000242,GO:2000253,GO:2000479,GO:2000480,GO:2001141	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	RIIa,cNMP_binding
TLS3_k127_2879262_0	1286171.EAL2_c20530	4.741e-21	108.0	COG3209@1|root,COG4886@1|root,COG3209@2|Bacteria,COG4886@2|Bacteria,1UYAG@1239|Firmicutes,25BZ5@186801|Clostridia	186801|Clostridia	M	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2883590_1	1166018.FAES_1911	5.017e-45	169.0	COG2307@1|root,COG2307@2|Bacteria,4NHIB@976|Bacteroidetes,47JTD@768503|Cytophagia	976|Bacteroidetes	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
TLS3_k127_2883590_0	1123278.KB893409_gene38	1.147e-192	611.0	COG2308@1|root,COG2308@2|Bacteria,4NFMN@976|Bacteroidetes,47JU4@768503|Cytophagia	976|Bacteroidetes	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
TLS3_k127_2898143_0	1120999.JONM01000015_gene2952	5.41e-41	157.0	COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,2WH6G@28216|Betaproteobacteria,2KPNV@206351|Neisseriales	206351|Neisseriales	H	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS3_k127_2910458_1	98439.AJLL01000005_gene4414	2.748e-25	109.0	COG0745@1|root,COG3437@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1G2MH@1117|Cyanobacteria,1JI8Z@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
TLS3_k127_2910458_0	1120966.AUBU01000001_gene783	1.432e-26	116.0	COG0745@1|root,COG0745@2|Bacteria,4NRCB@976|Bacteroidetes,47QF3@768503|Cytophagia	976|Bacteroidetes	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_2910458_2	1173028.ANKO01000195_gene5985	1.796e-09	62.0	COG2202@1|root,COG2203@1|root,COG2905@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2905@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,1H8J3@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_9
TLS3_k127_2912817_1	1192034.CAP_1506	7.08e-08	60.0	297PQ@1|root,2ZUWM@2|Bacteria,1PYGM@1224|Proteobacteria,435C6@68525|delta/epsilon subdivisions,2WZPR@28221|Deltaproteobacteria,2Z2HB@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2912817_0	1210884.HG799469_gene14082	1.204e-34	141.0	COG2208@1|root,COG2905@1|root,COG2208@2|Bacteria,COG2905@2|Bacteria,2J1ZJ@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	CBS,SpoIIE
TLS3_k127_2926933_0	1226994.AMZB01000091_gene846	3.399e-51	188.0	COG2267@1|root,COG2267@2|Bacteria,1REM6@1224|Proteobacteria,1S4U1@1236|Gammaproteobacteria,1YEI2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_2926933_3	1237149.C900_02707	3.105e-15	77.0	COG2050@1|root,COG2050@2|Bacteria,4NQ15@976|Bacteroidetes	976|Bacteroidetes	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_2926933_1	1121930.AQXG01000006_gene801	2.911e-31	128.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS3_k127_2926933_2	314285.KT71_09542	7.215e-21	96.0	COG3686@1|root,COG3686@2|Bacteria,1N00R@1224|Proteobacteria,1S7JA@1236|Gammaproteobacteria,1JBR1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
TLS3_k127_2926933_4	1957.JODX01000032_gene6079	3.335e-09	57.0	COG3568@1|root,COG3568@2|Bacteria,2HQV4@201174|Actinobacteria	201174|Actinobacteria	M	Jacalin-like lectin domain	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,Jacalin
TLS3_k127_2926945_0	748247.AZKH_p0093	3.507e-55	209.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2VH7E@28216|Betaproteobacteria,2KUEM@206389|Rhodocyclales	206389|Rhodocyclales	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TLS3_k127_2931197_0	452637.Oter_1546	2.564e-39	152.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TLS3_k127_2931197_1	452637.Oter_1545	2.637e-11	73.0	COG1894@1|root,COG3411@1|root,COG1894@2|Bacteria,COG3411@2|Bacteria,46S8J@74201|Verrucomicrobia,3K7HM@414999|Opitutae	2|Bacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	hoxF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K05587,ko:K17992,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TLS3_k127_2931940_2	930169.B5T_03809	2.754e-11	63.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1XH22@135619|Oceanospirillales	135619|Oceanospirillales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
TLS3_k127_2931940_1	748247.AZKH_4000	9.188e-59	204.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,2KWNB@206389|Rhodocyclales	206389|Rhodocyclales	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TLS3_k127_2931940_0	159087.Daro_0319	4.858e-68	233.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,2KV3R@206389|Rhodocyclales	206389|Rhodocyclales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
TLS3_k127_2932157_0	153721.MYP_216	1.104e-48	179.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,4NK8R@976|Bacteroidetes,47NFI@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS3_k127_2932157_1	637390.AFOH01000028_gene1332	6.89e-28	121.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,2NBUP@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Tetratricopeptide repeat	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS3_k127_293223_2	443254.Marpi_2102	2.104e-11	75.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.178	ko:K03825,ko:K06718	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06978	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,FR47,Inhibitor_I36,PI-PLC-X
TLS3_k127_293223_0	1382306.JNIM01000001_gene422	3.004e-30	132.0	COG0642@1|root,COG2205@2|Bacteria,2GBNP@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
TLS3_k127_293223_3	1123229.AUBC01000020_gene4399	3.583e-07	51.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TQZR@28211|Alphaproteobacteria,3JRQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	MA20_14685	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_293223_1	350688.Clos_1349	1.975e-12	67.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae	186801|Clostridia	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS3_k127_2938131_1	1480694.DC28_01175	8.902e-32	131.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS3_k127_2938131_0	671143.DAMO_0507	4.354e-113	374.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
TLS3_k127_2939891_0	926567.TheveDRAFT_0737	4.689e-75	280.0	COG0744@1|root,COG0744@2|Bacteria,3TA4T@508458|Synergistetes	508458|Synergistetes	M	penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS3_k127_2950642_7	1293054.HSACCH_00613	8.993e-16	81.0	COG0695@1|root,COG0695@2|Bacteria,1VEUW@1239|Firmicutes,24SIW@186801|Clostridia,3WC5K@53433|Halanaerobiales	186801|Clostridia	O	PFAM Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	GST_N_3,Glutaredoxin
TLS3_k127_2950642_6	321332.CYB_2713	5.03e-19	89.0	COG5007@1|root,COG5007@2|Bacteria,1GRBE@1117|Cyanobacteria,1H4EZ@1129|Synechococcus	1117|Cyanobacteria	K	Belongs to the BolA IbaG family	-	-	-	-	-	-	-	-	-	-	-	-	BolA
TLS3_k127_2950642_4	663932.KB902575_gene2457	3.079e-35	138.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2JSSH@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
TLS3_k127_2950642_3	1026882.MAMP_00148	1.609e-66	243.0	COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,1RYCF@1236|Gammaproteobacteria,461NY@72273|Thiotrichales	72273|Thiotrichales	U	glutamate--cysteine ligase	-	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GshA
TLS3_k127_2950642_1	313628.LNTAR_24344	6.027e-89	302.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	gshB	GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0042601,GO:0042763,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.2,6.3.2.3	ko:K01919,ko:K01920,ko:K05844	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R00894,R10993,R10994	RC00064,RC00090,RC00096,RC00141	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	iJN678.gshB	ATPgrasp_YheCD,GSH-S_ATP,GSH-S_N
TLS3_k127_2950642_0	1535422.ND16A_0352	1.154e-114	378.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,2Q697@267889|Colwelliaceae	1236|Gammaproteobacteria	V	ABC transporter	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_2950642_2	1127673.GLIP_4025	6.456e-82	280.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,46426@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Transport permease protein	yadH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS3_k127_2950642_5	296591.Bpro_2055	5.526e-33	138.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,4A9S4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
TLS3_k127_2950642_8	670307.HYPDE_32493	1.033e-12	71.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2U5AP@28211|Alphaproteobacteria,3N74K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS3_k127_2955248_0	91604.ID47_11640	1.14e-106	364.0	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,2TV5V@28211|Alphaproteobacteria,47F19@766|Rickettsiales	766|Rickettsiales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,dCache_1
TLS3_k127_2955248_2	411476.BACOVA_01093	4.671e-18	98.0	COG0457@1|root,COG0457@2|Bacteria,4NMWW@976|Bacteroidetes,2G2WZ@200643|Bacteroidia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF2974,NB-ARC,Sel1,TPR_10,TPR_12,TPR_2,TPR_7,TPR_8
TLS3_k127_2955248_1	483219.LILAB_12505	1.173e-46	177.0	COG0625@1|root,COG0625@2|Bacteria,1QA0M@1224|Proteobacteria,434R5@68525|delta/epsilon subdivisions,2WZ2A@28221|Deltaproteobacteria,2Z169@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS3_k127_2958321_0	395493.BegalDRAFT_0677	7.112e-22	97.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	carnitine dehydratase	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS3_k127_2958321_1	596151.DesfrDRAFT_3990	7.354e-15	83.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,42U9T@68525|delta/epsilon subdivisions,2WQPQ@28221|Deltaproteobacteria,2MCJT@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
TLS3_k127_2958321_2	1210046.B277_01624	5.308e-10	65.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4FJWD@85021|Intrasporangiaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_2960729_1	635013.TherJR_1014	7.323e-43	162.0	COG2949@1|root,COG2949@2|Bacteria,1V1FP@1239|Firmicutes,24HBG@186801|Clostridia,261DH@186807|Peptococcaceae	186801|Clostridia	S	PFAM DUF218 domain	-	-	-	ko:K03748	-	-	-	-	ko00000	-	-	-	DUF218
TLS3_k127_2960729_0	926550.CLDAP_00430	7.325e-54	201.0	COG0300@1|root,COG0300@2|Bacteria,2G8X2@200795|Chloroflexi	200795|Chloroflexi	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_2960729_2	518766.Rmar_2735	6.729e-05	48.0	COG1729@1|root,COG4232@1|root,COG1729@2|Bacteria,COG4232@2|Bacteria	2|Bacteria	CO	protein-disulfide reductase activity	-	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	TPR_16,TPR_6,Thioredoxin,Thioredoxin_7
TLS3_k127_2970983_0	748247.AZKH_4417	4.975e-101	340.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2W8YU@28216|Betaproteobacteria,2KXXB@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
TLS3_k127_2978409_0	1085623.GNIT_1475	3.947e-211	672.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,464P1@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG0514 Superfamily II DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
TLS3_k127_298286_0	481448.Minf_1828	5.53e-43	175.0	COG3011@1|root,COG3011@2|Bacteria,46U84@74201|Verrucomicrobia,37G6V@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	LMF1
TLS3_k127_299827_1	1089550.ATTH01000001_gene2391	2.28e-06	51.0	COG0642@1|root,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1FJVE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_299827_0	1250006.JHZZ01000001_gene3312	1.667e-07	64.0	COG2247@1|root,COG2273@1|root,COG2911@1|root,COG2982@1|root,COG3266@1|root,COG2247@2|Bacteria,COG2273@2|Bacteria,COG2911@2|Bacteria,COG2982@2|Bacteria,COG3266@2|Bacteria,4PKAY@976|Bacteroidetes,1IKRS@117743|Flavobacteriia	976|Bacteroidetes	M	Psort location Extracellular, score 9.64	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
TLS3_k127_3010653_2	517418.Ctha_0720	7.696e-25	106.0	COG2119@1|root,COG2119@2|Bacteria,1FFN7@1090|Chlorobi	1090|Chlorobi	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
TLS3_k127_3010653_1	398767.Glov_3085	3.453e-77	287.0	28JHJ@1|root,2Z9B3@2|Bacteria,1NXYE@1224|Proteobacteria,430WY@68525|delta/epsilon subdivisions,2WVTK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3010653_0	526224.Bmur_0623	1.666e-97	327.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	-	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS3_k127_3013593_1	589865.DaAHT2_1404	1.205e-75	265.0	COG3177@1|root,COG3177@2|Bacteria,1MX0V@1224|Proteobacteria,42RKK@68525|delta/epsilon subdivisions,2WNV3@28221|Deltaproteobacteria,2MK5P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS3_k127_3013593_2	1408473.JHXO01000008_gene2590	1.175e-60	213.0	COG3727@1|root,COG3727@2|Bacteria,4NQEH@976|Bacteroidetes,2FT9A@200643|Bacteroidia	976|Bacteroidetes	L	May nick specific sequences that contain T G mispairs resulting from m5C-deamination	vsr	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF559,Vsr
TLS3_k127_3013593_0	485918.Cpin_2562	3.714e-169	540.0	COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,1ISRP@117747|Sphingobacteriia	976|Bacteroidetes	H	PFAM C-5 cytosine-specific DNA methylase	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase,Eco57I
TLS3_k127_3014875_0	1209072.ALBT01000023_gene4104	4.242e-65	227.0	COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,1S4SG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-Transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
TLS3_k127_303163_0	1480694.DC28_10570	4.491e-32	134.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
TLS3_k127_3034868_0	565045.NOR51B_1342	2.799e-14	82.0	COG2010@1|root,COG2374@1|root,COG3391@1|root,COG2010@2|Bacteria,COG2374@2|Bacteria,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria	1224|Proteobacteria	M	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
TLS3_k127_3038635_1	429009.Adeg_0960	4.156e-68	250.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,42FCV@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS3_k127_3038635_3	644282.Deba_2187	1.323e-12	81.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42YI3@68525|delta/epsilon subdivisions,2WTI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_3038635_0	1449048.JQKU01000013_gene3306	1.72e-72	259.0	COG1063@1|root,COG1063@2|Bacteria,2GNS1@201174|Actinobacteria,2384Z@1762|Mycobacteriaceae	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
TLS3_k127_3038635_2	5722.XP_001308057.1	1.096e-25	119.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	ko:K15502,ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,DUF3447
TLS3_k127_3055082_1	1432050.IE4771_CH03653	8.584e-22	102.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2UPN8@28211|Alphaproteobacteria,4BAY1@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS3_k127_3055082_2	743722.Sph21_1597	1.659e-21	97.0	COG0713@1|root,COG0713@2|Bacteria,4NTBP@976|Bacteroidetes,1ISXN@117747|Sphingobacteriia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS3_k127_3055082_0	671143.DAMO_2706	3.397e-31	131.0	COG1009@1|root,COG1009@2|Bacteria,2NNM8@2323|unclassified Bacteria	2|Bacteria	CP	NADH-quinone oxidoreductase chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS3_k127_3056078_0	1118054.CAGW01000061_gene2493	3.82e-94	324.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,26RV3@186822|Paenibacillaceae	91061|Bacilli	C	Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_3061561_1	401526.TcarDRAFT_1804	4.792e-29	123.0	COG3635@1|root,COG3635@2|Bacteria,1UIDA@1239|Firmicutes,4H3R0@909932|Negativicutes	909932|Negativicutes	C	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
TLS3_k127_3061561_0	118161.KB235922_gene3409	1.144e-64	239.0	COG0248@1|root,COG0248@2|Bacteria,1FZZC@1117|Cyanobacteria,3VI1C@52604|Pleurocapsales	1117|Cyanobacteria	FP	Ppx GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
TLS3_k127_3074365_1	1227739.Hsw_2448	7.398e-27	109.0	COG2723@1|root,COG2723@2|Bacteria,4NEE2@976|Bacteroidetes,47NND@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 1	blgA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS3_k127_3074365_0	768671.ThimaDRAFT_0740	2.919e-81	280.0	COG1216@1|root,COG1216@2|Bacteria,1N5DV@1224|Proteobacteria,1T4CS@1236|Gammaproteobacteria,1WZQU@135613|Chromatiales	135613|Chromatiales	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_3082961_0	861299.J421_3929	1.851e-126	415.0	COG0247@1|root,COG0247@2|Bacteria,1ZSVB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
TLS3_k127_3082961_1	172045.KS04_19800	0.0001242	52.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZK0@117743|Flavobacteriia,34QE1@308865|Elizabethkingia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_3085383_0	573413.Spirs_2127	9.098e-18	91.0	COG0673@1|root,COG0673@2|Bacteria,2J6U4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS3_k127_3086676_0	526224.Bmur_0357	1.559e-08	65.0	COG3391@1|root,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
TLS3_k127_3087705_0	1121373.KB903666_gene1302	1.111e-129	426.0	COG0477@1|root,COG2814@2|Bacteria,4NG6X@976|Bacteroidetes,47KCB@768503|Cytophagia	976|Bacteroidetes	EGP	TIGRFAM Drug resistance transporter Bcr CflA subfamily	bcr	-	-	ko:K03446,ko:K07552	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.2,2.A.1.3	-	-	MFS_1
TLS3_k127_3092095_0	768710.DesyoDRAFT_3247	5.872e-24	106.0	COG1246@1|root,COG1246@2|Bacteria,1V6TZ@1239|Firmicutes,24KQF@186801|Clostridia,2626A@186807|Peptococcaceae	186801|Clostridia	E	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
TLS3_k127_3092095_2	203119.Cthe_0727	2.211e-05	56.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,3WSBV@541000|Ruminococcaceae	186801|Clostridia	K	Cell envelope-related transcriptional attenuator domain	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS3_k127_3092095_1	411467.BACCAP_04638	6.107e-19	94.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,2693I@186813|unclassified Clostridiales	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS3_k127_3094130_0	1463825.JNXC01000040_gene5232	1.72e-20	103.0	COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,2GK1D@201174|Actinobacteria,4EABX@85010|Pseudonocardiales	201174|Actinobacteria	M	Insecticide toxin TcdB middle/N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,SpvB,TcdB_toxin_midN
TLS3_k127_3099688_1	246197.MXAN_4938	1.259e-49	194.0	COG4223@1|root,COG4223@2|Bacteria,1NDYH@1224|Proteobacteria,433KY@68525|delta/epsilon subdivisions,2WXPE@28221|Deltaproteobacteria,2YZMD@29|Myxococcales	28221|Deltaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3099688_0	1254432.SCE1572_02535	1.802e-110	375.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2YURF@29|Myxococcales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS3_k127_3099688_2	596324.TREVI0001_1985	5.97e-43	181.0	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
TLS3_k127_3107279_0	5722.XP_001308377.1	2.463e-09	69.0	COG5271@1|root,KOG1808@2759|Eukaryota	2759|Eukaryota	M	Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits	-	-	-	ko:K14572	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	AAA_5
TLS3_k127_31190_0	1094980.Mpsy_2635	2.575e-78	272.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota,2NB35@224756|Methanomicrobia	224756|Methanomicrobia	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS3_k127_313082_0	1207063.P24_07061	3.515e-05	55.0	COG3170@1|root,COG3170@2|Bacteria,1QDEM@1224|Proteobacteria,2UCG6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	Protein of unknown function (DUF1207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1207
TLS3_k127_3132401_0	266779.Meso_0485	1.133e-123	422.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,43KFD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	PFAM Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_3140405_0	289376.THEYE_A0567	2.855e-120	398.0	COG1960@1|root,COG1960@2|Bacteria,3J13U@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_3140405_2	945713.IALB_0571	2.328e-44	169.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	ntcA	-	-	ko:K01420,ko:K10716,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko02000,ko03000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_3140405_3	929562.Emtol_0589	1.126e-18	87.0	2DI4K@1|root,3020V@2|Bacteria,4NV1J@976|Bacteroidetes,47S4A@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
TLS3_k127_3140405_1	1173028.ANKO01000116_gene5719	1.758e-64	226.0	COG2114@1|root,COG2114@2|Bacteria,1G6D6@1117|Cyanobacteria,1HB2S@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS3_k127_3140405_4	246194.CHY_1236	5.705e-18	94.0	COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,42GBA@68295|Thermoanaerobacterales	186801|Clostridia	L	SMART AAA ATPase	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
TLS3_k127_3140405_5	1218084.BBJK01000169_gene7838	3.704e-17	92.0	COG3735@1|root,COG3735@2|Bacteria,1N94S@1224|Proteobacteria,2VPYF@28216|Betaproteobacteria,1K26X@119060|Burkholderiaceae	28216|Betaproteobacteria	S	GumN family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
TLS3_k127_3144001_1	1336235.JAEG01000007_gene1663	2.739e-08	65.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TU0G@28211|Alphaproteobacteria,4B9K0@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS3_k127_3144001_0	697284.ERIC2_c02630	9.844e-132	428.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,26REN@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS3_k127_3145438_1	1210884.HG799466_gene12889	4.149e-08	62.0	COG1595@1|root,COG1595@2|Bacteria,2J16J@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_3145438_0	551275.KB899544_gene1472	1.511e-51	203.0	28M2S@1|root,2ZAH5@2|Bacteria,1MVH5@1224|Proteobacteria,2V6CQ@28211|Alphaproteobacteria,43WPI@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3165358_0	237368.SCABRO_03416	1.045e-147	477.0	COG1004@1|root,COG1004@2|Bacteria,2IXM4@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS3_k127_3167778_1	342113.DM82_3573	1.459e-08	61.0	2CK96@1|root,33BNP@2|Bacteria,1NQ5Q@1224|Proteobacteria,2W51E@28216|Betaproteobacteria,1KB8N@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3167778_0	323261.Noc_2177	2.106e-26	121.0	COG1216@1|root,COG1216@2|Bacteria,1QTEK@1224|Proteobacteria,1S5EC@1236|Gammaproteobacteria,1WZPW@135613|Chromatiales	135613|Chromatiales	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K12990	ko02024,ko02025,map02024,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2
TLS3_k127_3172962_0	153721.MYP_1448	2.298e-68	236.0	COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,47JE5@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS3_k127_3172962_1	391625.PPSIR1_02653	1.798e-12	78.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF637,Haemagg_act,He_PIG,Peptidase_S74,REJ,SprB
TLS3_k127_3173534_1	56110.Oscil6304_3669	2.515e-06	51.0	COG0265@1|root,COG2340@1|root,COG0265@2|Bacteria,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Beta_helix,CAP,DUF1565,PDZ_2,Trypsin_2
TLS3_k127_3173534_0	2002.JOEQ01000031_gene1616	8.546e-83	285.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria,4EHBQ@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_3173534_2	1122981.AUME01000041_gene1451	7.195e-06	53.0	COG0204@1|root,COG0204@2|Bacteria,4NG5R@976|Bacteroidetes,2FMJG@200643|Bacteroidia	976|Bacteroidetes	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_3185172_2	399739.Pmen_3653	1.239e-48	186.0	COG3687@1|root,COG3687@2|Bacteria,1RBP4@1224|Proteobacteria,1S33P@1236|Gammaproteobacteria,1YFAE@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
TLS3_k127_3185172_0	1237500.ANBA01000018_gene3842	2.471e-58	213.0	COG0006@1|root,COG0006@2|Bacteria,2GMM9@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
TLS3_k127_3185172_1	1278073.MYSTI_04211	1.719e-55	220.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,42PAW@68525|delta/epsilon subdivisions,2WRY5@28221|Deltaproteobacteria,2YZMX@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TLS3_k127_3195081_0	1121033.AUCF01000015_gene1386	1.784e-61	222.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2U5Q5@28211|Alphaproteobacteria,2JS6E@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
TLS3_k127_3216294_0	1121861.KB899953_gene2389	4.839e-23	110.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_19255	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS3_k127_3226177_0	485918.Cpin_0441	0.0001486	49.0	COG0402@1|root,COG0402@2|Bacteria,4NJVU@976|Bacteroidetes,1IPAQ@117747|Sphingobacteriia	976|Bacteroidetes	F	amidohydrolase	-	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS3_k127_3231256_0	667014.Thein_1033	7.428e-40	155.0	COG1060@1|root,COG1060@2|Bacteria,2GH1Z@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
TLS3_k127_3231256_1	1519464.HY22_08670	0.0003126	53.0	COG1555@1|root,COG1555@2|Bacteria,1FE73@1090|Chlorobi	1090|Chlorobi	L	photosystem II stabilization	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
TLS3_k127_3236831_0	1040986.ATYO01000009_gene2261	3.506e-07	60.0	2EGVV@1|root,33AN3@2|Bacteria,1NJ5K@1224|Proteobacteria,2UHIK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3257168_1	515635.Dtur_0070	1.453e-07	59.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_3257168_0	1480694.DC28_10570	1.754e-33	148.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
TLS3_k127_3270130_1	489825.LYNGBM3L_53700	3.826e-12	78.0	COG1361@1|root,COG2373@1|root,COG3210@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CHU_C,Calx-beta,DUF11,SLH,SdrD_B
TLS3_k127_3270130_0	314230.DSM3645_16165	1.193e-61	224.0	2DNKJ@1|root,32XZB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3281309_1	1449126.JQKL01000005_gene946	2.706e-26	117.0	COG2755@1|root,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,24N6X@186801|Clostridia,269IA@186813|unclassified Clostridiales	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS3_k127_3281309_0	926564.KI911633_gene3104	5.857e-95	330.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4F3KI@85017|Promicromonosporaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_3283345_0	1122604.JONR01000004_gene863	6.987e-30	133.0	COG2239@1|root,COG2239@2|Bacteria,1RCPU@1224|Proteobacteria,1S1ZV@1236|Gammaproteobacteria,1X647@135614|Xanthomonadales	135614|Xanthomonadales	P	Acts as a magnesium transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3289139_0	666509.RCA23_c09320	6.368e-08	64.0	295B0@1|root,2ZSP6@2|Bacteria,1P5U8@1224|Proteobacteria,2UW4G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3289139_1	755732.Fluta_0056	4.083e-06	57.0	COG0790@1|root,COG0790@2|Bacteria,4NQ0M@976|Bacteroidetes	976|Bacteroidetes	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3289591_0	1047013.AQSP01000138_gene1052	7.178e-60	215.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	waaE	-	-	ko:K12984	-	-	-	-	ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2	-	Glyco_transf_7C,Glycos_transf_2
TLS3_k127_3289591_1	1069080.KB913028_gene245	2.367e-34	142.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4H4HE@909932|Negativicutes	909932|Negativicutes	M	Peptidase, M23 family	envC_2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_3294857_0	443144.GM21_0224	1.237e-08	64.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,42R1A@68525|delta/epsilon subdivisions,2WMV6@28221|Deltaproteobacteria,43THD@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TLS3_k127_3294857_1	391615.ABSJ01000030_gene822	0.0002344	52.0	COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer membrane lipoprotein-sorting protein	VP1287	-	-	-	-	-	-	-	-	-	-	-	LolA_like
TLS3_k127_3297909_1	640081.Dsui_1117	4.046e-08	63.0	COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,2VT8G@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_3297909_0	649639.Bcell_3869	1.339e-40	160.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_3300485_0	1265505.ATUG01000001_gene4400	6.524e-39	157.0	COG0596@1|root,COG0596@2|Bacteria,1QVQ5@1224|Proteobacteria,43BS7@68525|delta/epsilon subdivisions,2X730@28221|Deltaproteobacteria,2MM0E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_3300485_1	36874.HQ34_02170	4.057e-31	130.0	2CD2C@1|root,32W1R@2|Bacteria,4P2DW@976|Bacteroidetes,2FXPD@200643|Bacteroidia,2306U@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3300485_2	1500281.JQKZ01000024_gene2756	3.033e-05	53.0	COG3117@1|root,COG3117@2|Bacteria,4NUBA@976|Bacteroidetes,1I4SN@117743|Flavobacteriia,3ZR2V@59732|Chryseobacterium	976|Bacteroidetes	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	-	-	-	-	-	-	-	-	-	LptC
TLS3_k127_3307773_0	391587.KAOT1_14022	2.617e-207	648.0	COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,1HWUS@117743|Flavobacteriia	976|Bacteroidetes	C	SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS3_k127_3314825_0	1134413.ANNK01000052_gene1152	7.571e-13	71.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,4HABZ@91061|Bacilli,1ZB5W@1386|Bacillus	91061|Bacilli	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS3_k127_3317217_0	1278073.MYSTI_06430	2.651e-151	486.0	COG1075@1|root,COG1075@2|Bacteria,1PW38@1224|Proteobacteria,42Y6P@68525|delta/epsilon subdivisions,2WUDH@28221|Deltaproteobacteria,2YUDR@29|Myxococcales	28221|Deltaproteobacteria	S	with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3322532_1	458233.MCCL_0126	5.257e-31	129.0	COG0586@1|root,COG0586@2|Bacteria,1TS2R@1239|Firmicutes,4HA51@91061|Bacilli,4GXBT@90964|Staphylococcaceae	91061|Bacilli	S	SNARE associated Golgi protein	apl	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	SNARE_assoc
TLS3_k127_3322532_0	1353529.M899_0348	1.576e-66	229.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2MSUV@213481|Bdellovibrionales,2WJJR@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Belongs to the glutamate synthase family	-	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_7,Fer4_9,GXGXG,Glu_syn_central,Glu_synthase
TLS3_k127_3324345_1	1123354.AUDR01000014_gene1030	1.634e-08	57.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1KRKU@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
TLS3_k127_3324345_0	1205680.CAKO01000029_gene5246	6.817e-153	494.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS3_k127_3360404_0	665942.HMPREF1022_01282	3.214e-43	172.0	COG0642@1|root,COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2M7Z5@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,Cache_3-Cache_2,HAMP,HATPase_c_2,SpoIIE,dCache_1,dCache_2
TLS3_k127_3360404_1	1500281.JQKZ01000002_gene1572	5.414e-21	96.0	COG0500@1|root,COG2226@2|Bacteria,4NJTP@976|Bacteroidetes	976|Bacteroidetes	Q	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25,Methyltransf_31
TLS3_k127_3361531_0	1150600.ADIARSV_0845	6.156e-100	333.0	COG0315@1|root,COG0521@1|root,COG0315@2|Bacteria,COG0521@2|Bacteria,4NHA0@976|Bacteroidetes,1INZV@117747|Sphingobacteriia	976|Bacteroidetes	H	Molybdenum cofactor biosynthesis protein	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaC
TLS3_k127_3361531_1	714943.Mucpa_5095	7.997e-32	134.0	COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes,1IQAR@117747|Sphingobacteriia	976|Bacteroidetes	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS3_k127_3369882_0	755732.Fluta_1604	7.265e-127	420.0	COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,1HWQS@117743|Flavobacteriia,2PAE8@246874|Cryomorphaceae	976|Bacteroidetes	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_3374039_2	1379281.AVAG01000046_gene326	6.773e-31	123.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2M9GZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS3_k127_3374039_0	1123277.KB893194_gene5854	3.106e-226	709.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47MNC@768503|Cytophagia	976|Bacteroidetes	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140,ko:K22187	ko00040,ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00040,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935,R11768	RC00004,RC00080,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_3374039_1	714943.Mucpa_6393	2.857e-103	340.0	COG0161@1|root,COG0161@2|Bacteria,4PMIJ@976|Bacteroidetes,1J0MX@117747|Sphingobacteriia	976|Bacteroidetes	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
TLS3_k127_3374321_0	290318.Cvib_1556	1.456e-08	65.0	COG1561@1|root,COG1561@2|Bacteria,1FDEB@1090|Chlorobi	1090|Chlorobi	S	PFAM YicC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TLS3_k127_3389223_0	1304284.L21TH_0445	9.104e-144	462.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,36EKQ@31979|Clostridiaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS3_k127_3404548_1	330214.NIDE0040	8.445e-15	81.0	COG3678@1|root,COG3678@2|Bacteria	2|Bacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ,Metal_resist
TLS3_k127_3404548_0	1218084.BBJK01000061_gene4714	4.555e-18	96.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,1K1JH@119060|Burkholderiaceae	28216|Betaproteobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	OapA,Peptidase_M23
TLS3_k127_3404899_1	330214.NIDE3522	6.705e-34	140.0	COG3182@1|root,COG3182@2|Bacteria	2|Bacteria	E	Iron-regulated membrane protein	-	-	-	ko:K09939	-	-	-	-	ko00000	-	-	-	PepSY_TM,PepSY_TM_like_2
TLS3_k127_3404899_0	1266925.JHVX01000002_gene955	6.826e-50	185.0	COG5266@1|root,COG5266@2|Bacteria,1MXVN@1224|Proteobacteria,2VQ7F@28216|Betaproteobacteria,373WI@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM Nickel transport complex, NikM subunit, transmembrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
TLS3_k127_3404899_2	323848.Nmul_A2391	1.022e-30	127.0	COG4774@1|root,COG4774@2|Bacteria,1R085@1224|Proteobacteria,2VZCP@28216|Betaproteobacteria,372AP@32003|Nitrosomonadales	28216|Betaproteobacteria	M	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS3_k127_3406_1	765952.PUV_26190	2.049e-08	64.0	COG0642@1|root,COG2205@2|Bacteria,2JGMN@204428|Chlamydiae	204428|Chlamydiae	T	Osmosensitive K+ channel His kinase sensor domain	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,KdpD
TLS3_k127_3406_0	1385935.N836_26825	3.348e-38	157.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G1PT@1117|Cyanobacteria,1H7NV@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,PAS,PAS_8
TLS3_k127_3407739_1	215803.DB30_4226	0.0006958	50.0	COG4191@1|root,COG4191@2|Bacteria,1R95R@1224|Proteobacteria,42PEG@68525|delta/epsilon subdivisions,2WM8J@28221|Deltaproteobacteria,2YU43@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_3407739_2	381666.H16_B2443	0.0008858	51.0	COG2984@1|root,COG2984@2|Bacteria,1RD74@1224|Proteobacteria,2W0AP@28216|Betaproteobacteria,1JZY3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
TLS3_k127_3407739_0	247490.KSU1_C0452	3.047e-10	69.0	COG1629@1|root,COG4771@2|Bacteria,2J2B7@203682|Planctomycetes	203682|Planctomycetes	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TLS3_k127_3412648_0	404380.Gbem_0589	2.742e-05	54.0	COG4795@1|root,COG4795@2|Bacteria,1NPEC@1224|Proteobacteria,42WZG@68525|delta/epsilon subdivisions,2WSPB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein J	gspJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
TLS3_k127_3415708_0	215803.DB30_5157	4.577e-102	338.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS3_k127_3415708_1	1122221.JHVI01000005_gene524	2.883e-35	139.0	COG0476@1|root,COG0476@2|Bacteria,1WIMK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	COGs COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS3_k127_3420474_1	589865.DaAHT2_0873	1.864e-63	222.0	COG3287@1|root,COG3287@2|Bacteria,1R474@1224|Proteobacteria,42PVH@68525|delta/epsilon subdivisions,2WMB4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
TLS3_k127_3420474_2	264462.Bd1657	8.957e-52	200.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2MSXW@213481|Bdellovibrionales,2WIZU@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_3420474_3	1287276.X752_02460	1.499e-10	71.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,43GXK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	response regulator	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_3420474_0	880073.Calab_1764	5.901e-73	272.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_3425137_0	661478.OP10G_0131	6.591e-24	116.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS3_k127_343601_0	95619.PM1_0208115	1.23e-148	491.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG2366 Protein related to penicillin acylase	quiP	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS3_k127_3437253_0	584708.Apau_0857	1.022e-63	227.0	COG1291@1|root,COG1291@2|Bacteria,3T9XE@508458|Synergistetes	508458|Synergistetes	N	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS3_k127_3437253_1	1307761.L21SP2_1189	4.42e-39	156.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS3_k127_3437284_1	399739.Pmen_0469	2.263e-12	79.0	COG2199@1|root,COG2199@2|Bacteria,1QTT5@1224|Proteobacteria,1T1G8@1236|Gammaproteobacteria,1YKZS@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	7TMR-DISM extracellular 2	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
TLS3_k127_3437284_0	1396141.BATP01000060_gene4588	3.445e-33	136.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_3437284_2	572480.Arnit_1949	5.024e-07	59.0	COG4254@1|root,COG4254@2|Bacteria,1NBPR@1224|Proteobacteria,42SEW@68525|delta/epsilon subdivisions,2YPKM@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS3_k127_3440323_0	864702.OsccyDRAFT_3141	1.612e-76	264.0	COG0388@1|root,COG0388@2|Bacteria,1G103@1117|Cyanobacteria,1H8CV@1150|Oscillatoriales	1117|Cyanobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
TLS3_k127_3440323_2	158189.SpiBuddy_1206	1.79e-05	51.0	COG0360@1|root,COG0360@2|Bacteria,2J88X@203691|Spirochaetes	203691|Spirochaetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS3_k127_3440323_1	583355.Caka_1586	6.443e-30	123.0	COG0629@1|root,COG0629@2|Bacteria,46VZR@74201|Verrucomicrobia,3K80H@414999|Opitutae	414999|Opitutae	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS3_k127_3451031_0	877418.ATWV01000001_gene1451	7.047e-68	249.0	COG0513@1|root,COG0513@2|Bacteria,2J5U7@203691|Spirochaetes	203691|Spirochaetes	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS3_k127_3459367_0	1101195.Meth11DRAFT_0944	1.361e-256	797.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,2KKF1@206350|Nitrosomonadales	206350|Nitrosomonadales	E	PFAM Orn Lys Arg decarboxylase major region	-	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
TLS3_k127_3459367_1	1242864.D187_009245	9.501e-186	602.0	COG2133@1|root,COG2133@2|Bacteria,1QTS4@1224|Proteobacteria	1224|Proteobacteria	G	Neutral/alkaline non-lysosomal ceramidase, C-terminal	-	-	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk,Ceramidse_alk_C
TLS3_k127_3459734_0	644283.Micau_3359	1.14e-51	194.0	COG3000@1|root,COG3000@2|Bacteria,2GMF0@201174|Actinobacteria,4DCC5@85008|Micromonosporales	201174|Actinobacteria	I	Fatty acid hydroxylase superfamily	erg3	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_3466966_3	1472716.KBK24_0107545	2.215e-10	70.0	COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,2VN6F@28216|Betaproteobacteria,1K0RM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
TLS3_k127_3466966_2	32057.KB217482_gene8779	1.49e-97	331.0	COG0075@1|root,COG0075@2|Bacteria,1G123@1117|Cyanobacteria,1HIKF@1161|Nostocales	1117|Cyanobacteria	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS3_k127_3466966_1	388467.A19Y_2947	1.417e-121	402.0	COG0028@1|root,COG4032@1|root,COG0028@2|Bacteria,COG4032@2|Bacteria,1G36U@1117|Cyanobacteria,1HFJ5@1150|Oscillatoriales	1117|Cyanobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS3_k127_3466966_0	573413.Spirs_4230	2.064e-178	572.0	COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,2J5AR@203691|Spirochaetes	203691|Spirochaetes	GIM	Phosphoenolpyruvate phosphomutase	aepX	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NTP_transf_3,PEP_mutase
TLS3_k127_3468386_0	1284679.HMPREF1626_04835	4.009e-15	80.0	COG2197@1|root,COG2197@2|Bacteria,2IG7B@201174|Actinobacteria,4D7WP@85005|Actinomycetales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_3468386_1	94122.Shewana3_0739	3.212e-14	79.0	COG0840@1|root,COG2703@1|root,COG0840@2|Bacteria,COG2703@2|Bacteria,1RBB1@1224|Proteobacteria,1S265@1236|Gammaproteobacteria,2Q9DW@267890|Shewanellaceae	1236|Gammaproteobacteria	NPT	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin,MCPsignal
TLS3_k127_348307_0	1232683.ADIMK_4121	9.624e-163	526.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,464I1@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS3_k127_348307_1	1002339.HMPREF9373_0143	1.744e-74	256.0	COG0512@1|root,COG0512@2|Bacteria,1MXP3@1224|Proteobacteria,1RRY2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS3_k127_3495266_2	1123274.KB899409_gene442	7.825e-45	169.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_3495266_0	243233.MCA2588	1.236e-83	290.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1XDVU@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
TLS3_k127_3495266_3	1265505.ATUG01000001_gene3056	5.523e-34	145.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TLS3_k127_3495266_1	395493.BegalDRAFT_1262	3.192e-67	247.0	COG5316@1|root,COG5316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TLS3_k127_3495266_4	1158345.JNLL01000001_gene228	7.41e-14	78.0	COG1472@1|root,COG1472@2|Bacteria,2G52S@200783|Aquificae	200783|Aquificae	G	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
TLS3_k127_3497469_0	1120968.AUBX01000010_gene1272	5.61e-69	255.0	COG1858@1|root,COG1858@2|Bacteria,4NE4P@976|Bacteroidetes,47K55@768503|Cytophagia	976|Bacteroidetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS3_k127_3501227_2	439235.Dalk_4049	8.843e-41	157.0	COG1545@1|root,COG1545@2|Bacteria,1NV6I@1224|Proteobacteria,42ZHC@68525|delta/epsilon subdivisions,2WUSN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
TLS3_k127_3501227_0	706587.Desti_5425	4.71e-151	486.0	COG0183@1|root,COG0183@2|Bacteria,1MY04@1224|Proteobacteria,42YW2@68525|delta/epsilon subdivisions,2WTJX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_N
TLS3_k127_3501227_1	439235.Dalk_4047	6.109e-67	233.0	COG0183@1|root,COG0183@2|Bacteria,1RGC4@1224|Proteobacteria,42YMT@68525|delta/epsilon subdivisions,2WUC2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	-
TLS3_k127_3504827_0	395493.BegalDRAFT_1407	2.185e-97	341.0	COG2114@1|root,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria	1224|Proteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	cyaH	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS3_k127_3504827_1	649747.HMPREF0083_06086	3.589e-09	66.0	COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,4HKHP@91061|Bacilli,26X64@186822|Paenibacillaceae	91061|Bacilli	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS3_k127_3509246_0	396513.SCA_0735	2.576e-89	303.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,4HAQ6@91061|Bacilli,4GX13@90964|Staphylococcaceae	91061|Bacilli	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
TLS3_k127_3509246_3	1492738.FEM21_27660	0.0001122	52.0	2A0QH@1|root,30NUW@2|Bacteria,4PB9V@976|Bacteroidetes,1IDED@117743|Flavobacteriia,2NY4U@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3509246_1	641524.ADICYQ_1418	7.535e-30	129.0	COG1999@1|root,COG1999@2|Bacteria,4NFH2@976|Bacteroidetes,47PXC@768503|Cytophagia	976|Bacteroidetes	S	PFAM SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS3_k127_3509246_2	929562.Emtol_0831	2.581e-13	77.0	COG2849@1|root,COG2849@2|Bacteria,4NT5E@976|Bacteroidetes,47UTZ@768503|Cytophagia	976|Bacteroidetes	S	MORN repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
TLS3_k127_3509519_2	498848.TaqDRAFT_3931	1.313e-24	108.0	COG1848@1|root,COG1848@2|Bacteria,1WKJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3509519_3	604331.AUHY01000038_gene136	8.81e-09	60.0	2DGZ3@1|root,2ZXUD@2|Bacteria,1WKRC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS3_k127_3509519_0	1449126.JQKL01000008_gene229	1.738e-65	233.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1V06C@1239|Firmicutes,24GWM@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3509519_1	1437448.AZRT01000019_gene1256	5.025e-37	150.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2U6XK@28211|Alphaproteobacteria,1J1KK@118882|Brucellaceae	28211|Alphaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS3_k127_3511933_1	1123226.KB899277_gene1452	0.0003215	45.0	COG1680@1|root,COG1680@2|Bacteria,1V7PM@1239|Firmicutes,4HIHX@91061|Bacilli,26SA9@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,SH3_8
TLS3_k127_3511933_0	1041146.ATZB01000002_gene5169	7.7e-65	237.0	COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,4B7FU@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	cyaG2	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_3515943_2	1282876.BAOK01000002_gene680	3.5e-20	95.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,4BRSZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
TLS3_k127_3515943_0	316055.RPE_4276	1.154e-85	303.0	COG0840@1|root,COG3829@1|root,COG0840@2|Bacteria,COG3829@2|Bacteria,1MU9B@1224|Proteobacteria,2TSBF@28211|Alphaproteobacteria,3JR3J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	aer	-	-	ko:K03406,ko:K03776	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,PilZ,TarH
TLS3_k127_3515943_1	933262.AXAM01000090_gene2614	1.505e-72	258.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42P0R@68525|delta/epsilon subdivisions,2WIKC@28221|Deltaproteobacteria,2MIC3@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS3_k127_3516100_0	332101.JIBU02000008_gene637	1.146e-12	82.0	COG5263@1|root,COG5263@2|Bacteria	2|Bacteria	S	dextransucrase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CW_binding_1,Flg_new,Mac-1,SLH
TLS3_k127_3517750_0	1394178.AWOO02000012_gene3771	2.03e-24	108.0	COG4308@1|root,COG4308@2|Bacteria,2IN4A@201174|Actinobacteria	201174|Actinobacteria	Q	limonene-1,2-epoxide hydrolase	ephG	GO:0003674,GO:0003824,GO:0004301,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016801,GO:0016803,GO:0018904,GO:0033963,GO:0044237,GO:0044281,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0097176,GO:1901360	3.3.2.8	ko:K10533	ko00903,map00903	-	R05784,R09387	RC01473,RC02519	ko00000,ko00001,ko01000	-	-	-	LEH
TLS3_k127_3517750_1	1151119.KB895518_gene2612	1.482e-12	68.0	COG2513@1|root,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria,1W7IE@1268|Micrococcaceae	201174|Actinobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
TLS3_k127_3525514_1	1304888.ATWF01000001_gene1992	8.145e-06	59.0	COG3291@1|root,COG3391@1|root,COG5276@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.2.1.91	ko:K19668,ko:K20276	ko00500,ko01100,ko02020,ko02024,map00500,map01100,map02020,map02024	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CHU_C,PKD,TSP_3
TLS3_k127_3525514_0	765914.ThisiDRAFT_1386	8.954e-07	63.0	COG0515@1|root,COG0515@2|Bacteria,1N79H@1224|Proteobacteria,1SD3H@1236|Gammaproteobacteria,1X2BS@135613|Chromatiales	135613|Chromatiales	KLT	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
TLS3_k127_3526610_1	335543.Sfum_1413	3.912e-31	129.0	COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,2MQBC@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_3526610_0	635013.TherJR_1014	3.179e-41	161.0	COG2949@1|root,COG2949@2|Bacteria,1V1FP@1239|Firmicutes,24HBG@186801|Clostridia,261DH@186807|Peptococcaceae	186801|Clostridia	S	PFAM DUF218 domain	-	-	-	ko:K03748	-	-	-	-	ko00000	-	-	-	DUF218
TLS3_k127_3526610_2	1237149.C900_03168	1.162e-23	104.0	COG4270@1|root,COG4270@2|Bacteria,4NVXH@976|Bacteroidetes,47WJK@768503|Cytophagia	976|Bacteroidetes	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS3_k127_3526610_3	293826.Amet_0771	3.896e-21	105.0	COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,36FX7@31979|Clostridiaceae	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
TLS3_k127_3539559_1	1144275.COCOR_04226	4.869e-10	71.0	COG3055@1|root,COG3055@2|Bacteria,1MYQG@1224|Proteobacteria,42P3T@68525|delta/epsilon subdivisions,2WKUC@28221|Deltaproteobacteria,2YZ03@29|Myxococcales	28221|Deltaproteobacteria	S	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,PKD
TLS3_k127_3539559_0	926692.AZYG01000048_gene2706	2.601e-60	213.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,3WAA7@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS3_k127_3573813_0	1121035.AUCH01000006_gene724	5.828e-74	252.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,2KUZ7@206389|Rhodocyclales	206389|Rhodocyclales	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS3_k127_3573813_1	391625.PPSIR1_38901	1.056e-23	117.0	COG1629@1|root,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
TLS3_k127_3575345_3	1403819.BATR01000127_gene4536	1.37e-26	112.0	COG0473@1|root,COG0473@2|Bacteria,46S4R@74201|Verrucomicrobia,2ITY1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS3_k127_3575345_2	748658.KB907313_gene2082	5.183e-35	149.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1SYRX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Protoglobin
TLS3_k127_3575345_0	1499968.TCA2_3830	8.176e-85	292.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,26QBA@186822|Paenibacillaceae	91061|Bacilli	S	Reductase	yvgN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_3575345_1	1408473.JHXO01000007_gene927	9.492e-72	259.0	COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,2FS28@200643|Bacteroidia	976|Bacteroidetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS3_k127_3576232_0	903818.KI912269_gene491	5.402e-263	820.0	COG0438@1|root,COG0438@2|Bacteria,3Y68X@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_3583635_0	1265502.KB905933_gene2053	6.472e-153	505.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,4A9JK@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS3_k127_3583635_3	1499967.BAYZ01000118_gene3298	4.256e-11	66.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Methyltransf_25,Trm112p
TLS3_k127_3583635_1	317936.Nos7107_2064	2.941e-72	251.0	2C8RK@1|root,2ZAIG@2|Bacteria,1G46D@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3583635_2	762903.Pedsa_3581	7.452e-18	84.0	COG5434@1|root,COG5434@2|Bacteria,4PN6D@976|Bacteroidetes,1IV5T@117747|Sphingobacteriia	976|Bacteroidetes	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3583652_0	1408428.JNJP01000125_gene2351	1.045e-31	130.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_3583652_1	754027.HMPREF9554_01972	6.644e-28	119.0	COG4741@1|root,COG4741@2|Bacteria,2J8ES@203691|Spirochaetes	203691|Spirochaetes	F	COGs COG4741 secreted endonuclease distantly related to Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
TLS3_k127_3590879_0	118163.Ple7327_0865	1.076e-151	497.0	COG1233@1|root,COG1233@2|Bacteria,1G4AK@1117|Cyanobacteria	1117|Cyanobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
TLS3_k127_3590879_1	386456.JQKN01000002_gene2496	4.187e-08	64.0	COG1305@1|root,arCOG02165@2157|Archaea,2XXMP@28890|Euryarchaeota,23PG0@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015,PMBR,Transglut_core
TLS3_k127_3590879_2	391598.FBBAL38_12930	1.097e-05	56.0	COG2319@1|root,COG2319@2|Bacteria,4NW8I@976|Bacteroidetes	976|Bacteroidetes	S	Wd-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3594236_1	1121930.AQXG01000006_gene808	2.297e-51	188.0	COG0642@1|root,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
TLS3_k127_3594236_0	880073.Calab_0968	1.258e-51	195.0	COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase, family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS3_k127_3594236_2	387631.Asulf_00227	5.211e-15	80.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2466I@183980|Archaeoglobi	183980|Archaeoglobi	F	thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS3_k127_3594572_0	468059.AUHA01000002_gene667	7.012e-95	325.0	COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,1INTU@117747|Sphingobacteriia	976|Bacteroidetes	J	PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS3_k127_3594572_1	1121904.ARBP01000018_gene2687	4.95e-44	175.0	COG4775@1|root,COG4775@2|Bacteria,4NICB@976|Bacteroidetes,47PNV@768503|Cytophagia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
TLS3_k127_3605100_0	1353529.M899_1094	3.726e-47	182.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2MTD2@213481|Bdellovibrionales,2WNGS@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
TLS3_k127_3605100_1	1249997.JHZW01000002_gene1415	4.451e-28	120.0	2ARAZ@1|root,31GKZ@2|Bacteria,4NKJD@976|Bacteroidetes,1I0HH@117743|Flavobacteriia,2PIEC@252356|Maribacter	976|Bacteroidetes	S	Domain of unknown function (DUF3332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3332
TLS3_k127_3607180_1	157072.XP_008868796.1	1.33e-44	166.0	COG0329@1|root,2QQ8M@2759|Eukaryota	2759|Eukaryota	EM	4-hydroxy-tetrahydrodipicolinate synthase	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS,Saccharop_dh_N
TLS3_k127_3607180_0	1123234.AUKI01000011_gene1291	2.545e-198	631.0	COG2303@1|root,COG2303@2|Bacteria,4NIU5@976|Bacteroidetes,1HZQ2@117743|Flavobacteriia	976|Bacteroidetes	E	Cholesterol oxidase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
TLS3_k127_3607180_2	1235457.C404_22750	4.14e-11	73.0	COG2706@1|root,COG3391@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,1RB38@1224|Proteobacteria,2VSAM@28216|Betaproteobacteria,1K6NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_3616387_0	580332.Slit_2461	2.399e-118	391.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,2VN24@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
TLS3_k127_3616387_1	580332.Slit_1755	9.574e-57	200.0	COG2933@1|root,COG2933@2|Bacteria,1MWBM@1224|Proteobacteria,2VJ71@28216|Betaproteobacteria,44VBJ@713636|Nitrosomonadales	28216|Betaproteobacteria	J	FtsJ-like methyltransferase	rlmM	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
TLS3_k127_3620370_1	504472.Slin_5304	3.1e-08	57.0	COG0584@1|root,COG0584@2|Bacteria,4NJ13@976|Bacteroidetes,47MVH@768503|Cytophagia	976|Bacteroidetes	C	Glycerophosphoryl diester phosphodiesterase family	-	-	-	-	-	-	-	-	-	-	-	-	GDPD
TLS3_k127_3620370_0	373903.Hore_10620	7.207e-25	108.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,24HJF@186801|Clostridia,3WBWF@53433|Halanaerobiales	186801|Clostridia	NT	PFAM Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS3_k127_3622574_2	33035.JPJF01000017_gene3762	2.635e-08	55.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,3XZEY@572511|Blautia	186801|Clostridia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TLS3_k127_3622574_0	926569.ANT_17330	1.28e-149	504.0	COG0366@1|root,COG0366@2|Bacteria,2G7SV@200795|Chloroflexi	200795|Chloroflexi	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
TLS3_k127_3622574_1	596324.TREVI0001_1973	3.123e-20	107.0	COG1640@1|root,COG1640@2|Bacteria,2J62I@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TLS3_k127_363844_0	1390370.O203_17145	3.87e-148	474.0	COG5285@1|root,COG5285@2|Bacteria,1PF68@1224|Proteobacteria,1RYF8@1236|Gammaproteobacteria,1YIHU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS3_k127_363844_1	1234595.C725_1047	3.223e-43	168.0	COG0300@1|root,COG0300@2|Bacteria,1R7MT@1224|Proteobacteria,2TXPY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_3640643_0	313606.M23134_02904	3.447e-282	878.0	COG1032@1|root,COG1032@2|Bacteria,4NGYA@976|Bacteroidetes,47JD7@768503|Cytophagia	976|Bacteroidetes	C	Domain of unknown function (DUF3362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
TLS3_k127_3658528_3	1392487.JIAD01000001_gene825	2.352e-22	100.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,25UZZ@186806|Eubacteriaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS3_k127_3658528_0	519989.ECTPHS_01899	1.311e-97	332.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS3_k127_3658528_2	349521.HCH_01685	1.179e-36	153.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RN5Z@1236|Gammaproteobacteria,1XI47@135619|Oceanospirillales	135619|Oceanospirillales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_3658528_4	1355374.JARU01000018_gene2003	3.467e-09	63.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42VNG@68525|delta/epsilon subdivisions,2YQ9F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS3_k127_3658528_1	1123240.ATVO01000005_gene1953	1.5e-60	218.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,2K107@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS3_k127_3666472_0	522306.CAP2UW1_3204	1.283e-83	286.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_3666472_1	1307761.L21SP2_3208	2.971e-06	55.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_3674504_0	290397.Adeh_1737	2.949e-20	104.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1R8QH@1224|Proteobacteria,42T02@68525|delta/epsilon subdivisions,2WPNU@28221|Deltaproteobacteria,2YUP3@29|Myxococcales	28221|Deltaproteobacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
TLS3_k127_3680046_1	402777.KB235904_gene3390	2.845e-13	83.0	COG0689@1|root,COG2931@1|root,COG3391@1|root,COG4257@1|root,COG4932@1|root,COG5184@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4257@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,1GBCU@1117|Cyanobacteria	1117|Cyanobacteria	DMQZ	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,HemolysinCabind
TLS3_k127_3680046_0	762903.Pedsa_2026	2.396e-53	212.0	COG3391@1|root,COG4447@1|root,COG4886@1|root,COG5492@1|root,COG3391@2|Bacteria,COG4447@2|Bacteria,COG4886@2|Bacteria,COG5492@2|Bacteria,4NNEF@976|Bacteroidetes	976|Bacteroidetes	M	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TIG
TLS3_k127_3680046_2	204773.HEAR0188	1.048e-05	57.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VR04@28216|Betaproteobacteria,4732V@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
TLS3_k127_3683523_1	1313421.JHBV01000023_gene5162	4.966e-22	105.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1IPCA@117747|Sphingobacteriia	976|Bacteroidetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_3683523_0	1238450.VIBNISOn1_820127	8.668e-72	254.0	COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,1S1MD@1236|Gammaproteobacteria,1XTY5@135623|Vibrionales	135623|Vibrionales	T	COG0784 FOG CheY-like receiver	-	-	-	-	-	-	-	-	-	-	-	-	EAL,Response_reg
TLS3_k127_3694744_1	329726.AM1_5107	1.156e-19	105.0	COG0515@1|root,COG0642@1|root,COG2202@1|root,COG2203@1|root,COG3437@1|root,COG3829@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	1.8.1.9,2.7.13.3	ko:K00384,ko:K03407,ko:K11527	ko00450,ko02020,ko02030,map00450,map02020,map02030	M00506	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	AAA_16,GAF,GAF_2,GGDEF,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Pkinase,Response_reg
TLS3_k127_3694744_0	163908.KB235896_gene1015	4.561e-64	249.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HTUY@1161|Nostocales	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
TLS3_k127_3697651_1	1207075.PputUW4_01094	5.099e-07	54.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS3_k127_3697651_0	555088.DealDRAFT_2039	4.474e-51	190.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,42JN2@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS3_k127_3700335_0	1167006.UWK_01449	3.752e-16	86.0	COG1309@1|root,COG1309@2|Bacteria,1PHGD@1224|Proteobacteria,43DZQ@68525|delta/epsilon subdivisions,2WZAD@28221|Deltaproteobacteria,2MM92@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_3706259_0	388413.ALPR1_00335	7.158e-56	200.0	COG0531@1|root,COG0531@2|Bacteria,4NH3Q@976|Bacteroidetes,47JXZ@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	eutP	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	AA_permease_2
TLS3_k127_3711466_5	1121904.ARBP01000017_gene5086	1.073e-08	60.0	COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,4P0FM@976|Bacteroidetes,47TWT@768503|Cytophagia	976|Bacteroidetes	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS3_k127_3711466_3	1313304.CALK_1282	1.223e-52	190.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
TLS3_k127_3711466_2	1313304.CALK_1283	2.568e-94	334.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	Peptidase_M28,V_ATPase_I
TLS3_k127_3711466_4	1313304.CALK_1284	7.494e-38	151.0	COG1394@1|root,COG1394@2|Bacteria	2|Bacteria	C	ATPase activity, coupled to transmembrane movement of substances	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
TLS3_k127_3711466_0	1121129.KB903372_gene389	1.19e-218	685.0	COG1156@1|root,COG1156@2|Bacteria,4NIH8@976|Bacteroidetes,2FNPF@200643|Bacteroidia,22WY4@171551|Porphyromonadaceae	976|Bacteroidetes	C	the B subunit is part of the catalytic core of the ATP synthase complex	ntpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS3_k127_3711466_1	459349.CLOAM1052	5.608e-218	685.0	COG1155@1|root,COG1155@2|Bacteria,2NNYK@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
TLS3_k127_3719890_1	572547.Amico_0891	4.069e-43	163.0	COG0673@1|root,COG0673@2|Bacteria,3T9WN@508458|Synergistetes	508458|Synergistetes	S	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_3719890_0	1105367.CG50_12275	3.76e-79	273.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS3_k127_3723809_0	1449126.JQKL01000030_gene2495	2.043e-118	392.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,2687C@186813|unclassified Clostridiales	186801|Clostridia	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS3_k127_3728362_0	338963.Pcar_1980	5.688e-48	189.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2WMIZ@28221|Deltaproteobacteria,43S2P@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_3731851_0	509191.AEDB02000021_gene3118	7.462e-85	285.0	COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,24A3M@186801|Clostridia,3WIR5@541000|Ruminococcaceae	186801|Clostridia	F	TIGRFAM deoxycytidine triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
TLS3_k127_3731851_1	1123386.AUIW01000001_gene436	9.608e-53	191.0	COG0489@1|root,COG0489@2|Bacteria,1WIVB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS3_k127_3736703_0	880072.Desac_2171	3.658e-48	183.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
TLS3_k127_3747394_0	1313421.JHBV01000030_gene2082	3.134e-67	233.0	COG3000@1|root,COG3000@2|Bacteria,4NFWX@976|Bacteroidetes	976|Bacteroidetes	I	sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_3747394_1	889378.Spiaf_0742	9.348e-37	147.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
TLS3_k127_3756396_0	670307.HYPDE_29018	1.584e-15	86.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,3N6CC@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS3_k127_3756396_1	1382230.ASAP_2399	0.0004972	46.0	COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,2TWIW@28211|Alphaproteobacteria,2JSAI@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_3760718_1	743722.Sph21_0648	5.248e-26	113.0	2BRKF@1|root,32KJQ@2|Bacteria,4NRDC@976|Bacteroidetes,1IUMT@117747|Sphingobacteriia	976|Bacteroidetes	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
TLS3_k127_3760718_0	391615.ABSJ01000027_gene213	2.458e-140	457.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RREW@1236|Gammaproteobacteria,1J5DX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1454 Alcohol dehydrogenase, class IV	dhaT	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS3_k127_3772575_0	865938.Weevi_2029	2.659e-156	503.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1HX21@117743|Flavobacteriia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
TLS3_k127_3781352_0	570417.WP1379	2.533e-25	122.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47FE1@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
TLS3_k127_3786006_0	311402.Avi_5260	0.0003759	55.0	COG3468@1|root,COG3534@1|root,COG4625@1|root,COG3468@2|Bacteria,COG3534@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2U54N@28211|Alphaproteobacteria,4BB7H@82115|Rhizobiaceae	28211|Alphaproteobacteria	MU	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,fn3
TLS3_k127_379352_2	1005999.GLGR_0614	5.708e-06	55.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS3_k127_379352_1	7222.FBpp0146996	2.924e-42	162.0	COG2340@1|root,KOG3017@2759|Eukaryota,3A626@33154|Opisthokonta,3BSR6@33208|Metazoa,3D8BE@33213|Bilateria,42A16@6656|Arthropoda,3SZGF@50557|Insecta,453UN@7147|Diptera,45U5I@7214|Drosophilidae	33208|Metazoa	S	SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.	-	GO:0000003,GO:0005575,GO:0005576,GO:0008150,GO:0032501,GO:0032504	-	-	-	-	-	-	-	-	-	-	CAP
TLS3_k127_379352_0	1156935.QWE_08931	2.156e-71	250.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,2U2YW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bile acid	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
TLS3_k127_3796683_0	1121439.dsat_2192	2.293e-41	167.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2M9FY@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS3_k127_3796683_1	1101195.Meth11DRAFT_0668	5.39e-28	122.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria,2KKPM@206350|Nitrosomonadales	206350|Nitrosomonadales	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
TLS3_k127_3796683_2	1397693.KK211187_gene2576	9.479e-17	88.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,4HIHG@91061|Bacilli,3WG4E@539002|Bacillales incertae sedis	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS3_k127_3801572_3	906968.Trebr_2238	3.728e-23	104.0	COG1640@1|root,COG1640@2|Bacteria,2J62I@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TLS3_k127_3801572_0	589865.DaAHT2_0475	1.701e-157	518.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS3_k127_3801572_1	1336233.JAEH01000011_gene2932	1.086e-54	214.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,2QB0B@267890|Shewanellaceae	1236|Gammaproteobacteria	G	Starch synthase catalytic domain protein	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	iSFV_1184.SFV_3438	Glyco_transf_5,Glycos_transf_1
TLS3_k127_380164_0	1227266.HMPREF1551_01504	2.37e-39	150.0	COG0147@1|root,COG0147@2|Bacteria,4NFKB@976|Bacteroidetes,1HX4G@117743|Flavobacteriia,1EQPY@1016|Capnocytophaga	976|Bacteroidetes	EH	Psort location Cytoplasmic, score 9.97	pabB	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Chorismate_bind
TLS3_k127_380164_1	1089547.KB913013_gene3890	3.884e-33	136.0	COG0115@1|root,COG0115@2|Bacteria,4NSFJ@976|Bacteroidetes,47PY5@768503|Cytophagia	976|Bacteroidetes	EH	Amino-transferase class IV	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
TLS3_k127_3807734_0	933262.AXAM01000099_gene212	2.671e-104	349.0	COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,42ZPX@68525|delta/epsilon subdivisions,2WV2B@28221|Deltaproteobacteria,2MND9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
TLS3_k127_3807734_1	1191523.MROS_1761	4.052e-46	177.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_3807734_2	1121899.Q764_10325	2.981e-36	145.0	COG1409@1|root,COG1409@2|Bacteria,4NNCZ@976|Bacteroidetes,1I4VN@117743|Flavobacteriia,2NW6I@237|Flavobacterium	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
TLS3_k127_3811622_2	706587.Desti_3299	7.088e-14	79.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,42MX0@68525|delta/epsilon subdivisions,2WM16@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM Multi antimicrobial extrusion protein MatE	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_3811622_1	868864.Dester_0062	2.151e-55	206.0	COG0223@1|root,COG0223@2|Bacteria,2G3PD@200783|Aquificae	200783|Aquificae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS3_k127_3811622_0	305900.GV64_08950	6.002e-94	319.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1XH4R@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS3_k127_3816079_1	640081.Dsui_0938	9.177e-63	227.0	COG2206@1|root,COG2206@2|Bacteria,1PE9G@1224|Proteobacteria,2W060@28216|Betaproteobacteria,2KY83@206389|Rhodocyclales	206389|Rhodocyclales	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
TLS3_k127_3816079_0	649638.Trad_1638	7.137e-175	568.0	COG0441@1|root,COG0441@2|Bacteria,1WI8Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS3_k127_3817668_0	287.DR97_912	1.217e-120	406.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1YF1C@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Penicillin amidase	quiP	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS3_k127_3818099_2	666686.B1NLA3E_10455	3.233e-14	84.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
TLS3_k127_3818099_1	35128.Thaps10363	3.223e-14	81.0	2E1RF@1|root,2S91I@2759|Eukaryota	2759|Eukaryota	S	Cysteine-rich motif following a subset of SET domains	-	-	-	-	-	-	-	-	-	-	-	-	SET
TLS3_k127_3818099_0	456442.Mboo_1047	1.933e-58	220.0	COG5310@1|root,arCOG05182@2157|Archaea,2Y2E8@28890|Euryarchaeota,2NAFG@224756|Methanomicrobia	224756|Methanomicrobia	Q	Saccharopine dehydrogenase C-terminal domain	-	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2685	Sacchrp_dh_C,Sacchrp_dh_NADP
TLS3_k127_384611_2	666681.M301_0483	4.653e-24	110.0	COG4191@1|root,COG4585@1|root,COG4191@2|Bacteria,COG4585@2|Bacteria,1N1PW@1224|Proteobacteria,2VU49@28216|Betaproteobacteria	28216|Betaproteobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS3_k127_384611_0	1167006.UWK_01724	5.968e-45	170.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,42PU2@68525|delta/epsilon subdivisions,2WNAG@28221|Deltaproteobacteria,2MJ6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_384611_1	1379270.AUXF01000002_gene1845	2.628e-25	110.0	2CB8G@1|root,2Z88H@2|Bacteria,1ZV93@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
TLS3_k127_3864455_0	1278073.MYSTI_02663	5.969e-103	346.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,43C6E@68525|delta/epsilon subdivisions,2WTIV@28221|Deltaproteobacteria,2YZ25@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_3867717_0	641491.DND132_2165	5.64e-21	98.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WPUW@28221|Deltaproteobacteria,2MC6E@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
TLS3_k127_3867717_1	1255043.TVNIR_1503	2.147e-10	66.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,1S97S@1236|Gammaproteobacteria,1WYZX@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
TLS3_k127_3867717_2	593117.TGAM_0968	9.228e-09	66.0	COG0515@1|root,arCOG03264@1|root,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota,243VX@183968|Thermococci	183968|Thermococci	T	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS3_k127_3897640_0	1267533.KB906738_gene2403	2.764e-47	178.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HisKA,Response_reg,SpoIIE
TLS3_k127_3904614_1	66269.NL54_13810	1.336e-15	81.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,3VYIF@53335|Pantoea	1236|Gammaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	dadX	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iWFL_1372.ECW_m1275,iYL1228.KPN_02308	Ala_racemase_C,Ala_racemase_N
TLS3_k127_3904614_0	349519.LCK_01519	3.022e-26	113.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,4HH7S@91061|Bacilli,4AXNV@81850|Leuconostocaceae	91061|Bacilli	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
TLS3_k127_3904614_2	439235.Dalk_3280	6.536e-11	71.0	COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,43AR5@68525|delta/epsilon subdivisions,2X653@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Bacterial regulatory proteins TetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
TLS3_k127_3927840_0	522772.Dacet_1322	1.467e-44	169.0	COG0344@1|root,COG0344@2|Bacteria,2GFJ8@200930|Deferribacteres	200930|Deferribacteres	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
TLS3_k127_3935068_1	373994.Riv7116_4628	1.16e-27	116.0	COG2340@1|root,COG2340@2|Bacteria,1G68A@1117|Cyanobacteria,1HKMA@1161|Nostocales	1117|Cyanobacteria	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
TLS3_k127_3935068_0	1439940.BAY1663_03497	2.27e-57	215.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	ladS	-	2.7.13.3	ko:K20971,ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,Response_reg
TLS3_k127_3943684_2	211165.AJLN01000111_gene8	2.202e-14	76.0	COG1233@1|root,COG1233@2|Bacteria,1G086@1117|Cyanobacteria,1JHVT@1189|Stigonemataceae	1117|Cyanobacteria	Q	Flavin containing amine oxidoreductase	crtD	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS3_k127_3943684_0	1124780.ANNU01000006_gene2793	8.717e-118	393.0	COG3934@1|root,COG3934@2|Bacteria,4NH10@976|Bacteroidetes,47JD9@768503|Cytophagia	976|Bacteroidetes	G	Cellulase (glycosyl hydrolase family 5)	-	-	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase,Glyco_hydro_42
TLS3_k127_3943684_3	1034943.BN1094_00849	8.915e-12	74.0	COG2207@1|root,COG2207@2|Bacteria,1NJIJ@1224|Proteobacteria,1SZDR@1236|Gammaproteobacteria,1JESP@118969|Legionellales	118969|Legionellales	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_3943684_1	1219077.VAZ01S_056_00370	6.917e-19	94.0	28ME7@1|root,2ZARX@2|Bacteria,1R90X@1224|Proteobacteria,1SC25@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS3_k127_3947615_0	290397.Adeh_4143	8.902e-51	194.0	COG4258@1|root,COG4258@2|Bacteria,1QX7Z@1224|Proteobacteria,43C13@68525|delta/epsilon subdivisions,2X7BR@28221|Deltaproteobacteria,2YU55@29|Myxococcales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS3_k127_394920_0	69014.TK2170	1.623e-09	69.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,242SH@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_3949885_0	78898.MVEG_04008T0	7.171e-91	307.0	COG0005@1|root,KOG3985@2759|Eukaryota,38GVK@33154|Opisthokonta,3NV1I@4751|Fungi,1GSXX@112252|Fungi incertae sedis	4751|Fungi	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	MEU1	GO:0000096,GO:0000097,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004731,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009066,GO:0009067,GO:0009084,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS3_k127_3949885_1	290315.Clim_1411	3.506e-85	298.0	COG0260@1|root,COG0260@2|Bacteria,1FDFN@1090|Chlorobi	1090|Chlorobi	J	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS3_k127_3958142_0	759914.BP951000_1063	5.812e-47	177.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS3_k127_3958142_2	1219585.HMPREF1631_06020	6.42e-26	117.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4D373@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS3_k127_3958142_3	345341.KUTG_01801	1.592e-13	81.0	2E1SP@1|root,32X2I@2|Bacteria,2H4ID@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4436)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4436
TLS3_k127_3958142_5	1169152.AXVD01000014_gene1379	2.617e-07	59.0	2FE1I@1|root,3461R@2|Bacteria,2IRVY@201174|Actinobacteria,4G3G9@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3958142_4	1380384.JADN01000006_gene2603	5.533e-13	82.0	COG4585@1|root,COG4585@2|Bacteria,4NI8Z@976|Bacteroidetes,1HZHS@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,TPR_12,TPR_8
TLS3_k127_3958142_1	390989.JOEG01000003_gene4704	4.387e-37	148.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4DDRX@85008|Micromonosporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_3958423_0	1307761.L21SP2_0316	2.752e-31	133.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
TLS3_k127_3958423_1	1307761.L21SP2_0315	2.718e-21	109.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_3958423_2	158190.SpiGrapes_2916	4.537e-06	50.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS3_k127_397595_0	929703.KE386491_gene4054	1.574e-35	140.0	COG2166@1|root,COG2166@2|Bacteria,4NM9N@976|Bacteroidetes,47Q7A@768503|Cytophagia	976|Bacteroidetes	S	SufE protein probably involved in Fe-S center assembly	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
TLS3_k127_397724_0	646529.Desaci_2993	2.592e-42	162.0	COG1597@1|root,COG1597@2|Bacteria,1TQJH@1239|Firmicutes,24BHT@186801|Clostridia,261MX@186807|Peptococcaceae	186801|Clostridia	I	PFAM Diacylglycerol kinase catalytic domain	ytlR	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS3_k127_3979770_0	330214.NIDE2807	1.999e-159	516.0	COG0469@1|root,COG0469@2|Bacteria,3J0XM@40117|Nitrospirae	2|Bacteria	G	Belongs to the pyruvate kinase family	pykF	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS3_k127_3979770_2	1089548.KI783301_gene329	7.989e-45	169.0	COG2096@1|root,COG2096@2|Bacteria,1V3PI@1239|Firmicutes,4HH26@91061|Bacilli,3WFSA@539002|Bacillales incertae sedis	91061|Bacilli	S	Cobalamin adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS3_k127_3979770_3	759914.BP951000_1675	1.023e-09	70.0	COG2703@1|root,COG2703@2|Bacteria,2J8F9@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_3979770_4	1123354.AUDR01000002_gene1540	8.471e-05	54.0	COG2703@1|root,COG2703@2|Bacteria,1N8CP@1224|Proteobacteria,2WFA7@28216|Betaproteobacteria	1224|Proteobacteria	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_3979770_1	1191523.MROS_0244	5.779e-49	191.0	COG0642@1|root,COG2203@1|root,COG2204@1|root,COG3829@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_398138_0	667014.Thein_2118	1.126e-50	191.0	COG1216@1|root,COG1216@2|Bacteria,2GHKN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_3981671_1	29306.JOBE01000047_gene6183	9.452e-11	72.0	COG5620@1|root,COG5620@2|Bacteria,2IFHC@201174|Actinobacteria	201174|Actinobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3981671_2	570417.WP1379	9.776e-10	70.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47FE1@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
TLS3_k127_4004228_0	1201290.M902_0650	4.651e-31	136.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,43C9X@68525|delta/epsilon subdivisions,2MTUK@213481|Bdellovibrionales,2X7KD@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4006306_0	1444309.JAQG01000172_gene459	1.61e-16	89.0	COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,4HCC3@91061|Bacilli,26V43@186822|Paenibacillaceae	91061|Bacilli	NOU	peptidase	comC	-	3.4.23.43	ko:K02236,ko:K02654	-	M00331,M00429	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
TLS3_k127_4013608_1	521674.Plim_3062	3.191e-33	139.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	ko:K07011,ko:K19620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_21,Methyltransf_23,Methyltransf_25
TLS3_k127_4013608_0	1192034.CAP_1505	7.187e-54	205.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2Z380@29|Myxococcales	28221|Deltaproteobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,Cache_3-Cache_2,HAMP,HATPase_c_2,SpoIIE,dCache_1,dCache_2
TLS3_k127_4018409_0	446466.Cfla_3428	0.0007424	52.0	COG3209@1|root,COG3209@2|Bacteria,2I35N@201174|Actinobacteria	201174|Actinobacteria	M	sporulation resulting in formation of a cellular spore	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG,PT-HINT,RHS_repeat,Ricin_B_lectin
TLS3_k127_4018625_0	868595.Desca_0113	4.161e-101	338.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,260A4@186807|Peptococcaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS3_k127_4022765_0	349161.Dred_0165	1.119e-59	227.0	COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia,26046@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12010	QRPTase_C,QRPTase_N
TLS3_k127_4033023_0	1301100.HG529268_gene609	9.582e-79	273.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,36DP2@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS3_k127_4033023_1	1245471.PCA10_55430	3.146e-05	52.0	COG0810@1|root,COG0810@2|Bacteria,1MZXC@1224|Proteobacteria,1S4GB@1236|Gammaproteobacteria,1YGMK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	TonB C terminal	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
TLS3_k127_4041274_1	404589.Anae109_4099	1.643e-16	81.0	COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,42S7N@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_4041274_2	402777.KB235904_gene3247	1.103e-15	79.0	COG2442@1|root,COG2442@2|Bacteria,1GA44@1117|Cyanobacteria,1HDEZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS3_k127_4041274_0	1232437.KL662047_gene5244	6.934e-51	190.0	COG0847@1|root,COG0847@2|Bacteria,1PQ1V@1224|Proteobacteria,42PMC@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	dna polymerase iii	-	-	-	ko:K10857	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RNase_T
TLS3_k127_4041274_3	153721.MYP_4406	3.529e-05	49.0	COG4487@1|root,COG4487@2|Bacteria,4NGZ9@976|Bacteroidetes,47MY2@768503|Cytophagia	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2130)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
TLS3_k127_4044091_0	1298593.TOL_3684	6.942e-207	662.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1XHMG@135619|Oceanospirillales	135619|Oceanospirillales	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
TLS3_k127_4048133_1	1262449.CP6013_2824	4.227e-41	154.0	COG0685@1|root,COG0685@2|Bacteria,1UZX0@1239|Firmicutes,24B8V@186801|Clostridia,36HBZ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
TLS3_k127_4048133_5	211165.AJLN01000084_gene1758	2.763e-27	118.0	COG1309@1|root,COG1309@2|Bacteria,1G5S1@1117|Cyanobacteria,1JKJ0@1189|Stigonemataceae	1117|Cyanobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_4048133_4	1298593.TOL_3042	1.346e-28	122.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS3_k127_4048133_2	405948.SACE_3761	5.563e-37	147.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4E709@85010|Pseudonocardiales	201174|Actinobacteria	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_4048133_0	502025.Hoch_5371	2.17e-42	166.0	COG3687@1|root,COG3687@2|Bacteria,1R4HJ@1224|Proteobacteria,437ZS@68525|delta/epsilon subdivisions,2X9TG@28221|Deltaproteobacteria,2YV0P@29|Myxococcales	28221|Deltaproteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
TLS3_k127_4048133_6	1121957.ATVL01000008_gene4638	2.575e-20	94.0	2E5Q2@1|root,330EP@2|Bacteria,4NUMS@976|Bacteroidetes,47SBQ@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4048133_3	234267.Acid_7795	1.716e-34	138.0	COG1595@1|root,COG1595@2|Bacteria,3Y4KQ@57723|Acidobacteria	57723|Acidobacteria	K	region 4 type 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_4048639_1	340099.Teth39_0101	2.822e-25	117.0	COG0739@1|root,COG3583@1|root,COG0739@2|Bacteria,COG3583@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia,42FT7@68295|Thermoanaerobacterales	186801|Clostridia	M	G5 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	G5,LysM,Peptidase_M23
TLS3_k127_4048639_0	755732.Fluta_3555	6.706e-126	415.0	COG0113@1|root,COG0113@2|Bacteria,4NFW6@976|Bacteroidetes,1HX0W@117743|Flavobacteriia,2PAA0@246874|Cryomorphaceae	976|Bacteroidetes	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS3_k127_4049574_0	944481.JAFP01000001_gene226	8.509e-58	209.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,2M7IT@213113|Desulfurellales	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS3_k127_4049574_1	1340493.JNIF01000004_gene611	9.821e-12	70.0	COG0392@1|root,COG0392@2|Bacteria,3Y4Q3@57723|Acidobacteria	57723|Acidobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
TLS3_k127_4056458_0	909663.KI867150_gene822	1.257e-118	391.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_4056458_1	309801.trd_1606	2.664e-29	123.0	COG1215@1|root,COG1215@2|Bacteria,2G6BS@200795|Chloroflexi,27Y06@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_4057506_2	1122978.AUFP01000004_gene1881	2.392e-06	52.0	COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,2FM43@200643|Bacteroidia	976|Bacteroidetes	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS3_k127_4057506_1	1499967.BAYZ01000122_gene3398	6.927e-08	63.0	COG3221@1|root,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd,STAS_2
TLS3_k127_4057506_0	671143.DAMO_2592	2.3e-10	69.0	COG2984@1|root,COG2984@2|Bacteria,2NPCT@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
TLS3_k127_407300_5	742766.HMPREF9455_02195	1.996e-05	51.0	COG1664@1|root,COG1664@2|Bacteria,4NUZA@976|Bacteroidetes,2FUPU@200643|Bacteroidia,22YMZ@171551|Porphyromonadaceae	976|Bacteroidetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_407300_4	754027.HMPREF9554_01175	9.049e-23	107.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_407300_0	379066.GAU_3347	1.243e-68	248.0	COG2362@1|root,COG2362@2|Bacteria	2|Bacteria	E	D-aminopeptidase	dppA	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
TLS3_k127_407300_2	313628.LNTAR_22164	3.244e-62	227.0	COG3540@1|root,COG3540@2|Bacteria	2|Bacteria	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,fn2
TLS3_k127_407300_3	1484479.DI14_08890	1.757e-33	136.0	COG1695@1|root,COG1695@2|Bacteria,1V4KT@1239|Firmicutes,4HHKA@91061|Bacilli	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
TLS3_k127_407300_1	264462.Bd3715	1.726e-62	222.0	COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,42R0Z@68525|delta/epsilon subdivisions,2MU35@213481|Bdellovibrionales,2WMNE@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	PFAM NAD(P)H dehydrogenase (quinone)	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
TLS3_k127_4073864_0	85681.XP_006453607.1	1.594e-09	70.0	COG0204@1|root,KOG2848@2759|Eukaryota,37M0C@33090|Viridiplantae,3GDYJ@35493|Streptophyta	35493|Streptophyta	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	GO:0000003,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0007275,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009507,GO:0009526,GO:0009536,GO:0009790,GO:0009791,GO:0009793,GO:0009941,GO:0009987,GO:0010154,GO:0019637,GO:0022414,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458,GO:0071704,GO:0090407,GO:1901576	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_407921_2	215803.DB30_0827	1.17e-32	143.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,437Y9@68525|delta/epsilon subdivisions,2X9RZ@28221|Deltaproteobacteria,2YUSF@29|Myxococcales	28221|Deltaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
TLS3_k127_407921_0	1121904.ARBP01000007_gene3126	1.583e-74	259.0	COG4221@1|root,COG4221@2|Bacteria,4PKGY@976|Bacteroidetes,47JKE@768503|Cytophagia	976|Bacteroidetes	S	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_407921_3	1274374.CBLK010000015_gene2632	2.432e-08	64.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HJN1@91061|Bacilli,26XRF@186822|Paenibacillaceae	91061|Bacilli	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS3_k127_407921_1	714943.Mucpa_4390	4.679e-58	204.0	COG3158@1|root,COG3158@2|Bacteria,4NET9@976|Bacteroidetes,1IP14@117747|Sphingobacteriia	976|Bacteroidetes	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TLS3_k127_4082028_2	596324.TREVI0001_0337	0.0002984	50.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
TLS3_k127_4082028_0	246197.MXAN_0440	1.261e-52	211.0	COG4258@1|root,COG4258@2|Bacteria,1QX46@1224|Proteobacteria,42QK9@68525|delta/epsilon subdivisions,2WKGH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS3_k127_4082028_1	1261545.MBE-HAL_0920	0.0001227	51.0	COG0457@1|root,arCOG03032@2157|Archaea,2Y7M7@28890|Euryarchaeota,23TJM@183963|Halobacteria	183963|Halobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
TLS3_k127_4083062_2	240015.ACP_2951	1.857e-05	51.0	COG2706@1|root,COG2706@2|Bacteria,3Y76Q@57723|Acidobacteria,2JMA2@204432|Acidobacteriia	204432|Acidobacteriia	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_4083062_1	1265505.ATUG01000002_gene2637	4.077e-89	298.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria,42TRV@68525|delta/epsilon subdivisions,2WR3X@28221|Deltaproteobacteria,2MKTT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4083062_0	760192.Halhy_4720	4.261e-93	317.0	COG4690@1|root,COG4690@2|Bacteria	2|Bacteria	E	dipeptidase activity	-	-	-	ko:K14358	-	-	-	-	ko00000,ko01002	-	-	-	AAT,Peptidase_C69
TLS3_k127_408446_0	1157490.EL26_01085	1.923e-81	287.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,4HB2U@91061|Bacilli,279R8@186823|Alicyclobacillaceae	91061|Bacilli	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
TLS3_k127_408446_1	189425.PGRAT_26790	2.016e-66	233.0	COG3467@1|root,COG3467@2|Bacteria,1V62M@1239|Firmicutes,4HHYS@91061|Bacilli,26R2T@186822|Paenibacillaceae	91061|Bacilli	S	Flavin-nucleotide-binding protein	nimA	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
TLS3_k127_4093875_0	1122919.KB905552_gene574	2.465e-54	205.0	COG2220@1|root,COG2220@2|Bacteria,1TRRP@1239|Firmicutes,4HDF8@91061|Bacilli,26QGT@186822|Paenibacillaceae	91061|Bacilli	S	Zn-dependent hydrolases of the beta-lactamase fold	romA	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_4093875_1	269799.Gmet_2744	6.254e-19	94.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,42XCB@68525|delta/epsilon subdivisions,2WWYM@28221|Deltaproteobacteria,43VES@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
TLS3_k127_410348_1	251221.35210854	1.493e-60	214.0	COG1028@1|root,COG1028@2|Bacteria,1G4JP@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_410348_0	502025.Hoch_1681	2.805e-98	330.0	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,42NGH@68525|delta/epsilon subdivisions,2WKS6@28221|Deltaproteobacteria,2YV7C@29|Myxococcales	28221|Deltaproteobacteria	M	RmlD substrate binding domain	-	-	1.1.1.394,1.1.1.412	ko:K21271,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD
TLS3_k127_4105118_1	1288494.EBAPG3_17790	1.772e-61	216.0	COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,2VRUU@28216|Betaproteobacteria,372QX@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
TLS3_k127_4105118_0	580332.Slit_0284	4.292e-196	616.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,44VPE@713636|Nitrosomonadales	28216|Betaproteobacteria	M	MltA specific insert domain	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
TLS3_k127_4105296_0	1394178.AWOO02000068_gene264	1.413e-06	59.0	COG0204@1|root,COG0204@2|Bacteria,2GQVG@201174|Actinobacteria,4EQTH@85012|Streptosporangiales	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_4109273_0	179408.Osc7112_5529	2.741e-66	248.0	COG2931@1|root,COG2931@2|Bacteria,1G2XZ@1117|Cyanobacteria,1HEEK@1150|Oscillatoriales	1117|Cyanobacteria	Q	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,DUF4347,FG-GAP_2,VCBS
TLS3_k127_4110142_1	313628.LNTAR_16267	1.881e-65	233.0	COG0553@1|root,COG0553@2|Bacteria	2|Bacteria	L	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
TLS3_k127_4110142_0	1382359.JIAL01000001_gene240	6.879e-86	298.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
TLS3_k127_4110142_2	641143.HMPREF9331_00561	4.485e-42	158.0	COG0317@1|root,COG0317@2|Bacteria,4NRRN@976|Bacteroidetes,1I3TF@117743|Flavobacteriia,1ERZH@1016|Capnocytophaga	976|Bacteroidetes	KT	Phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
TLS3_k127_4128185_1	1227739.Hsw_3798	9.725e-20	94.0	COG1409@1|root,COG4775@1|root,COG1409@2|Bacteria,COG4775@2|Bacteria,4NF9N@976|Bacteroidetes,47JAP@768503|Cytophagia	976|Bacteroidetes	M	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,Metallophos,ShlB
TLS3_k127_4128185_0	414684.RC1_2263	1.425e-115	383.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,2JR48@204441|Rhodospirillales	204441|Rhodospirillales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_4133876_0	1117108.PAALTS15_22798	6.814e-87	297.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,4H9Q6@91061|Bacilli,26S6Y@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS3_k127_4133876_1	264462.Bd1776	6.277e-47	177.0	COG2866@1|root,COG2866@2|Bacteria,1N9AY@1224|Proteobacteria,430W9@68525|delta/epsilon subdivisions,2MSZJ@213481|Bdellovibrionales,2WW2T@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
TLS3_k127_4143540_2	1056816.JAFQ01000004_gene6100	7.086e-07	54.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4FTY2@85025|Nocardiaceae	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS3_k127_4143540_0	247490.KSU1_C1426	7.673e-75	265.0	COG0042@1|root,COG0042@2|Bacteria,2IYI5@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
TLS3_k127_4143540_1	876269.ARWA01000001_gene951	2.896e-46	175.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,3NAIA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS3_k127_4145600_1	938278.CAJO01000030_gene24	9.669e-30	128.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,2688N@186813|unclassified Clostridiales	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS3_k127_4145600_0	1089553.Tph_c00330	1.115e-50	189.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS3_k127_4146274_1	316067.Geob_2234	5.755e-10	66.0	COG2846@1|root,COG2846@2|Bacteria,1MVCQ@1224|Proteobacteria,42NXK@68525|delta/epsilon subdivisions,2WMGN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Di-iron-containing protein involved in the repair of iron-sulfur clusters	scdA	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
TLS3_k127_4146274_0	391625.PPSIR1_23629	5.842e-35	143.0	COG3687@1|root,COG3687@2|Bacteria,1R4HJ@1224|Proteobacteria	1224|Proteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
TLS3_k127_4153257_0	399549.Msed_0878	0.0002561	53.0	COG1305@1|root,arCOG02165@2157|Archaea,2XSH6@28889|Crenarchaeota	28889|Crenarchaeota	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TLS3_k127_4153793_0	1538295.JY96_08230	3.078e-73	251.0	COG3287@1|root,COG3287@2|Bacteria,1QUQH@1224|Proteobacteria,2VMN2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	FIST C domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
TLS3_k127_4153793_1	335543.Sfum_3112	9.25e-72	260.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MSIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_4153793_2	1101192.KB910516_gene3551	4.77e-20	99.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,1JT9M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_4153793_3	264462.Bd1657	1.307e-15	88.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2MSXW@213481|Bdellovibrionales,2WIZU@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_4176434_3	525903.Taci_1071	1.626e-07	53.0	COG1694@1|root,COG3956@2|Bacteria,3TAH9@508458|Synergistetes	508458|Synergistetes	S	TIGRFAM MazG family protein	-	-	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS3_k127_4176434_0	290397.Adeh_1963	9.988e-71	257.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2YU4J@29|Myxococcales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS3_k127_4176434_1	1288484.APCS01000117_gene766	6.635e-40	160.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS3_k127_4176434_2	572547.Amico_0994	1.99e-35	146.0	COG1922@1|root,COG1922@2|Bacteria,3T9T9@508458|Synergistetes	508458|Synergistetes	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
TLS3_k127_4178684_0	439235.Dalk_1136	2.357e-79	280.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WUG9@28221|Deltaproteobacteria,2MMW2@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_4183409_1	596324.TREVI0001_1188	6.969e-17	85.0	COG0218@1|root,COG0218@2|Bacteria,2J7H7@203691|Spirochaetes	203691|Spirochaetes	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
TLS3_k127_4183409_0	439235.Dalk_3382	1.703e-61	218.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,42S7V@68525|delta/epsilon subdivisions,2WNFD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TLS3_k127_4190350_0	1273538.G159_01365	1.295e-37	145.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,4HINV@91061|Bacilli,26FT7@186818|Planococcaceae	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_4194118_0	742817.HMPREF9449_02097	3.584e-26	117.0	COG5492@1|root,COG5492@2|Bacteria,4NH7Q@976|Bacteroidetes,2FN1I@200643|Bacteroidia,22WZ6@171551|Porphyromonadaceae	976|Bacteroidetes	N	COG NOG06100 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
TLS3_k127_4194118_1	768706.Desor_3611	3.699e-10	68.0	COG1595@1|root,COG1595@2|Bacteria,1V734@1239|Firmicutes,24MQB@186801|Clostridia,266EF@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_4210003_0	497964.CfE428DRAFT_4921	9.874e-14	83.0	COG3203@1|root,COG3203@2|Bacteria,46SY8@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS3_k127_4214939_0	879212.DespoDRAFT_01043	5.385e-194	617.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS3_k127_4215630_0	1120973.AQXL01000104_gene2602	1.245e-39	151.0	COG0394@1|root,COG0394@2|Bacteria,1V6SG@1239|Firmicutes,4HIZN@91061|Bacilli,278IZ@186823|Alicyclobacillaceae	91061|Bacilli	T	low molecular weight	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS3_k127_4215630_1	1394178.AWOO02000011_gene3985	8.941e-08	58.0	COG0139@1|root,COG0139@2|Bacteria	2|Bacteria	E	phosphoribosyl-AMP cyclohydrolase activity	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
TLS3_k127_4221816_0	1123058.KB894248_gene1320	2.871e-14	87.0	COG3209@1|root,COG3209@2|Bacteria,4NF0G@976|Bacteroidetes,1I0VK@117743|Flavobacteriia	976|Bacteroidetes	M	RHS repeat-associated core domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN
TLS3_k127_4224817_0	1283300.ATXB01000002_gene3083	1.02e-16	87.0	COG2230@1|root,COG2230@2|Bacteria,1QUR4@1224|Proteobacteria,1RP3C@1236|Gammaproteobacteria,1XF6I@135618|Methylococcales	135618|Methylococcales	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_4233380_3	545695.TREAZ_3018	1.187e-05	54.0	COG0598@1|root,COG0598@2|Bacteria,2J6SS@203691|Spirochaetes	203691|Spirochaetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS3_k127_4233380_2	886293.Sinac_1147	9.527e-58	214.0	COG0079@1|root,COG0079@2|Bacteria,2IWYA@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_4233380_1	1444309.JAQG01000013_gene1906	2.214e-58	214.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H9TB@91061|Bacilli,26RXG@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the ParB family	spo0J	GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	HTH_3,KorB,ParBc
TLS3_k127_4233380_0	580327.Tthe_2747	9.051e-63	220.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS3_k127_4239358_0	759914.BP951000_1335	1.745e-75	266.0	COG1256@1|root,COG1256@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
TLS3_k127_4242748_0	1045858.Bint_0433	4.83e-113	378.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
TLS3_k127_4245442_1	491952.Mar181_1053	2.714e-38	151.0	COG1011@1|root,COG1011@2|Bacteria,1QSY2@1224|Proteobacteria,1RWK3@1236|Gammaproteobacteria,1XM90@135619|Oceanospirillales	135619|Oceanospirillales	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_4245442_0	1198232.CYCME_1864	6.8e-99	330.0	COG0121@1|root,COG0121@2|Bacteria,1QWMA@1224|Proteobacteria,1T2WM@1236|Gammaproteobacteria,463UM@72273|Thiotrichales	72273|Thiotrichales	S	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
TLS3_k127_4245442_2	1215915.BN193_00665	3.908e-26	110.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,1YBPN@1357|Lactococcus	91061|Bacilli	J	structural constituent of ribosome	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS3_k127_4245442_3	1391647.AVSV01000022_gene2504	8.71e-14	75.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,36KGX@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS3_k127_4248740_0	269799.Gmet_0242	4.72e-43	176.0	COG1215@1|root,COG1215@2|Bacteria,1RJNP@1224|Proteobacteria,42ST7@68525|delta/epsilon subdivisions,2X7KP@28221|Deltaproteobacteria,43V18@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_4248740_1	997829.HMPREF1121_00063	2.434e-14	85.0	COG0795@1|root,COG0795@2|Bacteria,4NF8Y@976|Bacteroidetes,2FM2K@200643|Bacteroidia,22WPG@171551|Porphyromonadaceae	976|Bacteroidetes	S	Permease, YjgP YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS3_k127_4256157_1	203124.Tery_0958	5.076e-36	139.0	COG2843@1|root,COG2843@2|Bacteria,1G0W8@1117|Cyanobacteria,1H82Y@1150|Oscillatoriales	1117|Cyanobacteria	M	of poly-gamma-glutamate biosynthesis (Capsule	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS3_k127_4256157_0	926550.CLDAP_07340	2.399e-287	901.0	COG0542@1|root,COG0542@2|Bacteria,2G5QU@200795|Chloroflexi	200795|Chloroflexi	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS3_k127_4258970_1	1453500.AT05_04845	2.913e-22	114.0	COG3391@1|root,COG3391@2|Bacteria,4NI6H@976|Bacteroidetes	976|Bacteroidetes	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,DUF4842
TLS3_k127_4258970_0	449447.MAE_61060	2.529e-82	307.0	COG2931@1|root,COG2931@2|Bacteria,1GQCK@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM Hemolysin-type calcium-binding	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,DUF4347,HemolysinCabind,VCBS
TLS3_k127_4259364_2	492774.JQMB01000011_gene4265	0.0003497	47.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,4BA21@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS3_k127_4259364_0	264462.Bd0707	3.248e-71	258.0	COG1538@1|root,COG1538@2|Bacteria,1Q54S@1224|Proteobacteria,42W8E@68525|delta/epsilon subdivisions,2MTWA@213481|Bdellovibrionales,2WSDF@28221|Deltaproteobacteria	213481|Bdellovibrionales	MU	FusA NodT family protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
TLS3_k127_4259364_1	208444.JNYY01000011_gene2959	5.767e-12	72.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	MA20_27725	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
TLS3_k127_4260899_1	1408436.JHXY01000005_gene140	1.491e-07	63.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,25VI6@186806|Eubacteriaceae	186801|Clostridia	KLT	Psort location CytoplasmicMembrane, score	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS3_k127_4260899_0	1349767.GJA_1319	1.08e-24	119.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1MVV1@1224|Proteobacteria,2VMY9@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Insecticidal toxin complex protein TcaC	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TLS3_k127_4283379_1	215803.DB30_5174	7.183e-06	61.0	COG3291@1|root,COG5492@1|root,COG3291@2|Bacteria,COG5492@2|Bacteria,1PEIB@1224|Proteobacteria,439WA@68525|delta/epsilon subdivisions,2X5AJ@28221|Deltaproteobacteria,2YWZV@29|Myxococcales	28221|Deltaproteobacteria	N	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
TLS3_k127_4283379_0	502025.Hoch_5023	1.701e-08	69.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,43CW4@68525|delta/epsilon subdivisions,2WVX0@28221|Deltaproteobacteria,2YVBV@29|Myxococcales	28221|Deltaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4286202_1	498761.HM1_1060	2.911e-05	49.0	COG0745@1|root,COG0745@2|Bacteria	498761.HM1_1060|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4286202_0	41431.PCC8801_1495	7.035e-31	134.0	COG0642@1|root,COG2205@2|Bacteria,1FZVR@1117|Cyanobacteria,3KH28@43988|Cyanothece	1117|Cyanobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS3_k127_428946_2	1532558.JL39_07770	1.691e-36	144.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2UBRG@28211|Alphaproteobacteria,4BEYT@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_428946_3	290399.Arth_0431	1.334e-08	62.0	2DS51@1|root,33EJB@2|Bacteria,2IM77@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
TLS3_k127_428946_1	264462.Bd3675	3.081e-70	245.0	COG1309@1|root,COG1309@2|Bacteria,1RGCX@1224|Proteobacteria	1224|Proteobacteria	K	tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
TLS3_k127_428946_0	313606.M23134_06670	4.275e-91	310.0	COG2114@1|root,COG2114@2|Bacteria,4NEVN@976|Bacteroidetes,47MR3@768503|Cytophagia	976|Bacteroidetes	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_12,TPR_8
TLS3_k127_4291725_0	889378.Spiaf_0549	1.612e-97	331.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS3_k127_4308894_0	1049564.TevJSym_ca00050	7.704e-117	406.0	COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	MMPL family	VP1286	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS3_k127_4312467_0	358220.C380_12605	2.53e-61	216.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGKF@28216|Betaproteobacteria,4AGRT@80864|Comamonadaceae	28216|Betaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
TLS3_k127_4312467_2	1283299.AUKG01000006_gene774	4.17e-18	96.0	COG3693@1|root,COG3693@2|Bacteria	2|Bacteria	G	endo-1,4-beta-xylanase activity	abfB	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_62,RicinB_lectin_2,Ricin_B_lectin
TLS3_k127_4312467_1	311402.Avi_5235	9.388e-61	219.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2U27Q@28211|Alphaproteobacteria,4BBEZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_4316772_0	384676.PSEEN3007	2.428e-266	829.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,1S174@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
TLS3_k127_4316772_1	644968.DFW101_3098	5.724e-13	75.0	COG1846@1|root,COG1846@2|Bacteria,1N75F@1224|Proteobacteria,42VDI@68525|delta/epsilon subdivisions,2WR80@28221|Deltaproteobacteria,2MBD9@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS3_k127_4316772_2	760192.Halhy_1132	1.081e-12	74.0	2EPAX@1|root,33GXP@2|Bacteria,4NXI7@976|Bacteroidetes	976|Bacteroidetes	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
TLS3_k127_4331070_0	378806.STAUR_5811	1.802e-47	187.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WJRN@28221|Deltaproteobacteria,2YU22@29|Myxococcales	28221|Deltaproteobacteria	CO	Cytochrome C biogenesis protein transmembrane region	dbsD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7
TLS3_k127_4338365_0	929712.KI912613_gene4753	8.087e-33	139.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4CQIT@84995|Rubrobacteria	84995|Rubrobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS3_k127_4339617_2	247633.GP2143_07829	3.926e-13	77.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1T236@1236|Gammaproteobacteria,1JBSE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
TLS3_k127_4339617_0	387092.NIS_1045	5.494e-60	219.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2YMPZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	hmm pf04305	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
TLS3_k127_4339617_1	1235797.C816_03317	1.561e-42	164.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,2N6PT@216572|Oscillospiraceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
TLS3_k127_4347305_0	1268635.Loa_50p0040	2.177e-159	528.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1JDGI@118969|Legionellales	118969|Legionellales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	helA	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TLS3_k127_4347305_1	688245.CtCNB1_4384	0.0001196	53.0	COG1538@1|root,COG1538@2|Bacteria,1NEZC@1224|Proteobacteria,2VIMD@28216|Betaproteobacteria,4AA6D@80864|Comamonadaceae	28216|Betaproteobacteria	MU	PFAM Outer membrane efflux protein	czcC	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
TLS3_k127_4347780_0	1219065.VPR01S_01_01300	4.016e-30	123.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,1XXK3@135623|Vibrionales	135623|Vibrionales	T	Transmits chemoreceptor signals to flagelllar motor components	cheY-4	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS3_k127_4347780_1	1488328.JMCL01000030_gene2303	8.204e-17	83.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria	1224|Proteobacteria	K	response regulator	nreC	-	-	ko:K02479,ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS3_k127_4347780_2	1122176.KB903587_gene4371	1.14e-07	55.0	COG2197@1|root,COG2197@2|Bacteria,4NQNY@976|Bacteroidetes,1IY32@117747|Sphingobacteriia	976|Bacteroidetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_4353387_1	264462.Bd2589	1.817e-13	79.0	2C8ZN@1|root,34AAV@2|Bacteria,1P1YE@1224|Proteobacteria,43140@68525|delta/epsilon subdivisions,2MTCQ@213481|Bdellovibrionales,2WX14@28221|Deltaproteobacteria	213481|Bdellovibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4353387_0	760192.Halhy_0235	4.758e-197	629.0	COG2759@1|root,COG2759@2|Bacteria,4NG3E@976|Bacteroidetes,1IWIB@117747|Sphingobacteriia	976|Bacteroidetes	F	Formate--tetrahydrofolate ligase	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
TLS3_k127_4353893_0	1519464.HY22_13380	9.425e-68	238.0	COG0372@1|root,COG0372@2|Bacteria,1FD5Z@1090|Chlorobi	1090|Chlorobi	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_4353893_1	324057.Pjdr2_1232	3.866e-13	81.0	COG0438@1|root,COG0438@2|Bacteria,1TQN3@1239|Firmicutes,4HCKM@91061|Bacilli,26R4Q@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferase	rfaG1	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_4353893_2	545694.TREPR_3388	3.914e-12	75.0	COG4775@1|root,COG4775@2|Bacteria,2J7ZQ@203691|Spirochaetes	203691|Spirochaetes	M	SPTR Surface antigen variable number repeat	-	-	-	-	-	-	-	-	-	-	-	-	POTRA
TLS3_k127_4358555_2	926554.KI912640_gene1276	9.723e-60	213.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS3_k127_4358555_4	593750.Metfor_2573	2.003e-06	55.0	arCOG09584@1|root,arCOG09584@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4358555_1	1536773.R70331_24990	1.435e-133	436.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,4H9S1@91061|Bacilli,26QQ7@186822|Paenibacillaceae	91061|Bacilli	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS3_k127_4358555_0	765869.BDW_07875	2.779e-152	490.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42SFR@68525|delta/epsilon subdivisions,2MUPC@213481|Bdellovibrionales,2WPY1@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS3_k127_4358555_3	1408433.JHXV01000028_gene2125	7.383e-19	100.0	COG2849@1|root,COG2849@2|Bacteria,4NMDX@976|Bacteroidetes,1I51X@117743|Flavobacteriia,2PBC5@246874|Cryomorphaceae	976|Bacteroidetes	S	MORN repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2,TPR_16,TPR_8
TLS3_k127_4359102_0	545694.TREPR_2845	1.357e-94	315.0	COG1191@1|root,COG1191@2|Bacteria,2J5RA@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS3_k127_4359102_1	118163.Ple7327_0865	1.932e-48	177.0	COG1233@1|root,COG1233@2|Bacteria,1G4AK@1117|Cyanobacteria	1117|Cyanobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
TLS3_k127_4364813_0	1121116.KB894778_gene1911	2.03e-84	288.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,2WGFP@28216|Betaproteobacteria,4ACQW@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synt_N,Spermine_synth
TLS3_k127_436502_1	420662.Mpe_A2448	1.015e-08	64.0	COG1639@1|root,COG1639@2|Bacteria,1RASR@1224|Proteobacteria,2VR0D@28216|Betaproteobacteria,1KMTN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_436502_0	290317.Cpha266_1096	3.182e-17	89.0	28IZT@1|root,2Z8X3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4372072_5	755178.Cyan10605_1160	7.889e-06	54.0	COG5549@1|root,COG5549@2|Bacteria,1G4CD@1117|Cyanobacteria	1117|Cyanobacteria	O	Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
TLS3_k127_4372072_1	384765.SIAM614_27742	9.408e-65	250.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS3_k127_4372072_0	456442.Mboo_2044	1.036e-199	629.0	COG2873@1|root,arCOG00061@2157|Archaea,2XSWM@28890|Euryarchaeota,2N9AN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_4372072_2	626522.GCWU000325_00956	1.504e-38	158.0	COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,2FPCB@200643|Bacteroidia,1WD2M@1283313|Alloprevotella	976|Bacteroidetes	C	Domain of unknown function (DUF1730)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
TLS3_k127_4372072_3	1379698.RBG1_1C00001G0849	1.964e-26	114.0	COG1959@1|root,COG1959@2|Bacteria,2NQ8B@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, BadM Rrf2 family	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS3_k127_4372072_4	1230341.MJ3_08721	2.632e-13	78.0	COG1502@1|root,COG1502@2|Bacteria,1USPT@1239|Firmicutes,4HCJD@91061|Bacilli	91061|Bacilli	I	Belongs to the phospholipase D family. Cardiolipin synthase subfamily	clsB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0032502,GO:0043934,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS3_k127_4380605_0	869209.Tresu_1170	2.913e-13	83.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
TLS3_k127_4393966_3	10224.XP_002738480.1	3.87e-23	104.0	COG1234@1|root,2QVD0@2759|Eukaryota,39DCB@33154|Opisthokonta,3BZS3@33208|Metazoa,3DG8T@33213|Bilateria	33208|Metazoa	S	nuclear ribonuclease	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
TLS3_k127_4393966_4	1313421.JHBV01000009_gene4122	6.846e-17	91.0	COG1451@1|root,COG1451@2|Bacteria,4NIY4@976|Bacteroidetes,1IUYI@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS3_k127_4393966_1	1234664.AMRO01000027_gene1257	7.469e-37	149.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,4HCP6@91061|Bacilli,1WF41@129337|Geobacillus	91061|Bacilli	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS3_k127_4393966_0	639282.DEFDS_0100	6.815e-105	351.0	COG0216@1|root,COG0216@2|Bacteria,2GEM6@200930|Deferribacteres	200930|Deferribacteres	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS3_k127_4393966_2	398767.Glov_0671	1.711e-24	109.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,43TAE@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS3_k127_4400254_1	926562.Oweho_3482	1.482e-11	66.0	COG2197@1|root,COG2197@2|Bacteria,4NMTW@976|Bacteroidetes,1I1JF@117743|Flavobacteriia	976|Bacteroidetes	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	ko:K07696	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS3_k127_4400254_0	395961.Cyan7425_3210	7.486e-25	114.0	COG2199@1|root,COG3706@2|Bacteria,1G3NI@1117|Cyanobacteria,3KGTW@43988|Cyanothece	1117|Cyanobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TLS3_k127_440040_5	1349767.GJA_2322	8.798e-18	87.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,473P8@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS3_k127_440040_4	1121920.AUAU01000004_gene593	9.697e-24	106.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
TLS3_k127_440040_2	1313421.JHBV01000016_gene5724	6.072e-101	338.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS3_k127_440040_3	526224.Bmur_0107	1.019e-56	209.0	COG1655@1|root,COG1655@2|Bacteria,2J5GN@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225
TLS3_k127_440040_0	862908.BMS_2510	6.405e-132	433.0	COG1055@1|root,COG1055@2|Bacteria,1N68M@1224|Proteobacteria,42PD9@68525|delta/epsilon subdivisions,2MTG9@213481|Bdellovibrionales,2WKRV@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	Putative Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiport_3
TLS3_k127_440040_1	1202532.FF52_04370	4.608e-101	334.0	COG0289@1|root,COG0289@2|Bacteria,4NJJI@976|Bacteroidetes,1I01I@117743|Flavobacteriia,2NUD8@237|Flavobacterium	976|Bacteroidetes	E	Belongs to the DapB family	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS3_k127_4401133_0	1123060.JONP01000011_gene3082	9.723e-60	213.0	COG1414@1|root,COG1414@2|Bacteria,1R4S7@1224|Proteobacteria,2URNG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS3_k127_4402372_0	1304872.JAGC01000003_gene2473	1.613e-57	211.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_4402372_1	502025.Hoch_2176	8.305e-07	59.0	COG1807@1|root,COG1807@2|Bacteria,1Q2FK@1224|Proteobacteria,4381I@68525|delta/epsilon subdivisions,2X3BM@28221|Deltaproteobacteria,2YUUG@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_441177_0	744872.Spica_0475	4.49e-48	181.0	COG2172@1|root,COG2172@2|Bacteria,2J5HH@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS
TLS3_k127_441177_3	888832.HMPREF9420_2552	5.406e-07	63.0	COG5373@1|root,COG5373@2|Bacteria,4NGKV@976|Bacteroidetes,2FQAH@200643|Bacteroidia	976|Bacteroidetes	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
TLS3_k127_441177_1	933262.AXAM01000067_gene850	7.292e-17	83.0	COG2052@1|root,COG2052@2|Bacteria,1N0KP@1224|Proteobacteria,42TSK@68525|delta/epsilon subdivisions,2WQHH@28221|Deltaproteobacteria,2MKN3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the UPF0296 family	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
TLS3_k127_441177_2	314230.DSM3645_04595	9.775e-11	63.0	COG1561@1|root,COG1561@2|Bacteria,2IYZH@203682|Planctomycetes	203682|Planctomycetes	S	stress-induced protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TLS3_k127_4412999_2	1499684.CCNP01000020_gene2426	1.136e-09	70.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS3_k127_4412999_0	575540.Isop_1506	1.115e-44	169.0	COG0163@1|root,COG0163@2|Bacteria,2IZBH@203682|Planctomycetes	203682|Planctomycetes	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
TLS3_k127_4412999_1	1353529.M899_0691	2.972e-23	102.0	COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2WIPV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	radical SAM domain protein	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
TLS3_k127_4416682_0	234267.Acid_4959	3.317e-62	222.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y63K@57723|Acidobacteria	57723|Acidobacteria	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
TLS3_k127_4416682_1	1298593.TOL_1973	8.033e-17	84.0	COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,1T1MG@1236|Gammaproteobacteria,1XRVJ@135619|Oceanospirillales	135619|Oceanospirillales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_4418384_0	574087.Acear_2183	2.743e-74	261.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1TQ04@1239|Firmicutes,249KC@186801|Clostridia,3WACT@53433|Halanaerobiales	186801|Clostridia	M	Belongs to the SIS family. GutQ KpsF subfamily	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TLS3_k127_4418384_2	1296990.H845_1776	3.251e-06	53.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS3_k127_4418384_1	1116375.VEJY3_18331	2.458e-58	209.0	COG3911@1|root,COG3911@2|Bacteria,1RBSG@1224|Proteobacteria,1S31D@1236|Gammaproteobacteria,1XZZB@135623|Vibrionales	135623|Vibrionales	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
TLS3_k127_4425913_1	203122.Sde_0762	6.412e-12	74.0	2DTQU@1|root,33MB4@2|Bacteria,1NPT6@1224|Proteobacteria,1SISJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4425913_0	1173023.KE650771_gene2640	6.314e-117	389.0	COG0339@1|root,COG0339@2|Bacteria,1G05V@1117|Cyanobacteria,1JHIV@1189|Stigonemataceae	1117|Cyanobacteria	E	Peptidase family M3	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS3_k127_4436916_0	290318.Cvib_1650	3.608e-29	121.0	COG3876@1|root,COG3876@2|Bacteria,1FEP8@1090|Chlorobi	1090|Chlorobi	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
TLS3_k127_4436916_1	1184267.A11Q_1594	2.526e-21	96.0	2BQ39@1|root,32IXQ@2|Bacteria,1Q214@1224|Proteobacteria,437P2@68525|delta/epsilon subdivisions,2MU97@213481|Bdellovibrionales,2X2XA@28221|Deltaproteobacteria	213481|Bdellovibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4438507_2	456442.Mboo_0643	6.192e-41	173.0	COG2208@1|root,arCOG02362@1|root,arCOG02362@2157|Archaea,arCOG06893@2157|Archaea	2157|Archaea	KT	stage II sporulation	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
TLS3_k127_4438507_1	1532558.JL39_13440	1.394e-72	267.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,4B76T@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	gamma-glutamyltransferase	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS3_k127_4438507_0	1121104.AQXH01000012_gene288	3.918e-135	450.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1IW3G@117747|Sphingobacteriia	976|Bacteroidetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS3_k127_4438943_1	1144275.COCOR_02702	1.901e-13	72.0	COG2385@1|root,COG2385@2|Bacteria,1RGJS@1224|Proteobacteria,42RZE@68525|delta/epsilon subdivisions,2WNH8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Stage II sporulation D domain protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
TLS3_k127_4438943_0	667014.Thein_0915	2.959e-26	116.0	COG1267@1|root,COG1267@2|Bacteria,2GHUX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
TLS3_k127_4439666_1	1282356.H045_12915	2.461e-30	122.0	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,1S9G3@1236|Gammaproteobacteria,1YQJI@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
TLS3_k127_4439666_0	1191523.MROS_2107	1.639e-212	673.0	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS3_k127_4442426_0	796606.BMMGA3_14825	1.713e-151	488.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,4HB81@91061|Bacilli,1ZC50@1386|Bacillus	91061|Bacilli	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS3_k127_4442426_1	398767.Glov_0453	2.319e-68	246.0	COG1226@1|root,COG1226@2|Bacteria,1NT9G@1224|Proteobacteria,42TDE@68525|delta/epsilon subdivisions,2WP6G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Castor_Poll_mid,Ion_trans_2,TrkA_N
TLS3_k127_4442426_2	1548153.LR59_08775	2.646e-09	64.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2YPIZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	Staphylococcal nuclease homologues	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
TLS3_k127_4443509_1	1121899.Q764_07460	3.702e-73	250.0	COG0714@1|root,COG0714@2|Bacteria,4NGME@976|Bacteroidetes,1I0MP@117743|Flavobacteriia,2NUTI@237|Flavobacterium	976|Bacteroidetes	S	CbbQ/NirQ/NorQ C-terminal	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
TLS3_k127_4443509_0	1041826.FCOL_01560	8.829e-216	676.0	COG3256@1|root,COG3256@2|Bacteria,4NG9H@976|Bacteroidetes,1HZ9Q@117743|Flavobacteriia,2NUPQ@237|Flavobacterium	976|Bacteroidetes	C	Nitric oxide reductase large subunit	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
TLS3_k127_4453529_1	926550.CLDAP_05500	2.486e-08	56.0	COG1193@1|root,COG1193@2|Bacteria,2G5R8@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_III,MutS_V,Smr
TLS3_k127_4453529_0	644282.Deba_0874	1.765e-92	307.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS3_k127_4454402_1	688270.Celal_3014	2.301e-46	175.0	COG0739@1|root,COG0739@2|Bacteria,4NMHB@976|Bacteroidetes,1I1UE@117743|Flavobacteriia,1F9WJ@104264|Cellulophaga	976|Bacteroidetes	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_4454402_0	177437.HRM2_17310	8.578e-68	239.0	COG2356@1|root,COG2356@2|Bacteria,1MXQM@1224|Proteobacteria,42P2N@68525|delta/epsilon subdivisions,2WM4M@28221|Deltaproteobacteria,2MJF1@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Endonuclease I	-	-	3.1.21.1	ko:K01150	-	-	-	-	ko00000,ko01000	-	-	-	Endonuclease_1
TLS3_k127_4455602_0	243231.GSU1331	7.946e-21	104.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,43SU3@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23
TLS3_k127_4467396_0	926692.AZYG01000064_gene1044	1.055e-14	81.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,3WADY@53433|Halanaerobiales	186801|Clostridia	M	TIGRFAM penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS3_k127_4467741_1	717785.HYPMC_1759	1.317e-57	206.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,3N65T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS3_k127_4467741_0	1298858.AUEL01000014_gene634	2.427e-73	254.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2U7DN@28211|Alphaproteobacteria,43JZM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Bacterial sugar transferase	exoY	-	2.7.8.6	ko:K00996,ko:K16566	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf
TLS3_k127_4479696_1	1254432.SCE1572_52505	0.0003668	51.0	COG3031@1|root,COG3031@2|Bacteria,1NB50@1224|Proteobacteria,42WPG@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	General secretion pathway protein C	gspC	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PDZ_2,T2SSC
TLS3_k127_4479696_0	518766.Rmar_0878	1.059e-06	58.0	2AHGP@1|root,317U3@2|Bacteria,4P9B3@976|Bacteroidetes	976|Bacteroidetes	S	MerC mercury resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MerC
TLS3_k127_4481192_1	1121403.AUCV01000002_gene504	3.087e-31	125.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2MIVB@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran,GGDEF
TLS3_k127_4481192_0	1121396.KB892924_gene584	4.871e-35	139.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MK72@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS3_k127_4481192_4	471870.BACINT_03470	2.239e-21	97.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,4NERE@976|Bacteroidetes,2FKYQ@200643|Bacteroidia,4AKGU@815|Bacteroidaceae	976|Bacteroidetes	E	belongs to the PRA-CH family	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TLS3_k127_4481192_5	1123274.KB899421_gene1769	0.0001334	54.0	COG1413@1|root,COG1413@2|Bacteria,2J5WK@203691|Spirochaetes	203691|Spirochaetes	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
TLS3_k127_4481192_2	1041504.RATSFB_0031	6.769e-29	131.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_4481192_3	926566.Terro_1026	1.213e-27	126.0	COG1253@1|root,COG1253@2|Bacteria,3Y3MC@57723|Acidobacteria,2JIF9@204432|Acidobacteriia	204432|Acidobacteriia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_4482927_0	335543.Sfum_2657	1.036e-63	226.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,42PMH@68525|delta/epsilon subdivisions,2WKZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07641,ko:K14980	ko02020,map02020	M00449,M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
TLS3_k127_4482927_1	1200557.JHWV01000006_gene1862	2.538e-05	57.0	COG2208@1|root,COG5000@1|root,COG2208@2|Bacteria,COG5000@2|Bacteria,1TQY5@1239|Firmicutes,4H4HJ@909932|Negativicutes	909932|Negativicutes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
TLS3_k127_4488268_0	555079.Toce_1529	4.437e-83	293.0	COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia,42FDX@68295|Thermoanaerobacterales	186801|Clostridia	S	pfam abc1	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TLS3_k127_449183_1	1144342.PMI40_04980	3.336e-30	123.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2VQ72@28216|Betaproteobacteria,4746S@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
TLS3_k127_449183_0	243233.MCA2214	1.922e-86	293.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,1XECF@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
TLS3_k127_4498918_1	760142.Hipma_0327	7.652e-11	72.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42MJ7@68525|delta/epsilon subdivisions,2WIRS@28221|Deltaproteobacteria,2M6P3@213113|Desulfurellales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS3_k127_4498918_0	1121382.JQKG01000001_gene2270	3.386e-28	116.0	COG0722@1|root,COG0722@2|Bacteria,1WKXX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
TLS3_k127_4501168_1	1440774.Y900_015620	3.374e-53	191.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,233TJ@1762|Mycobacteriaceae	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS3_k127_4501168_0	388051.AUFE01000051_gene3020	2.274e-98	334.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2VN6N@28216|Betaproteobacteria,1K5TG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	e3 binding domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_4501168_3	1240349.ANGC01000099_gene966	1.675e-05	50.0	COG0236@1|root,COG0236@2|Bacteria,2GR2W@201174|Actinobacteria,4G799@85025|Nocardiaceae	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
TLS3_k127_4501168_2	1499686.BN1079_01864	5.139e-16	83.0	COG1017@1|root,COG1017@2|Bacteria,1RI9P@1224|Proteobacteria,1S7H7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4501177_0	404380.Gbem_2901	4.374e-106	349.0	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2WM7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Isocitrate dehydrogenase NADP-dependent, monomeric type	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
TLS3_k127_4501953_1	216432.CA2559_03260	4.069e-41	154.0	COG1233@1|root,COG1233@2|Bacteria,4NF31@976|Bacteroidetes,1HYWT@117743|Flavobacteriia	976|Bacteroidetes	Q	Flavin containing amine oxidoreductase	pys	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS3_k127_4501953_0	448385.sce5541	9.371e-205	651.0	2CB1C@1|root,2Z7M2@2|Bacteria,1Q9R6@1224|Proteobacteria,438X5@68525|delta/epsilon subdivisions,2X42J@28221|Deltaproteobacteria,2YY36@29|Myxococcales	28221|Deltaproteobacteria	S	Transmembrane protein of unknown function (DUF3556)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3556
TLS3_k127_4521172_0	1200792.AKYF01000009_gene3230	2.635e-76	271.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,4H9KB@91061|Bacilli,26SM0@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS3_k127_4521172_3	381764.Fnod_1231	1.173e-12	72.0	COG1366@1|root,COG1366@2|Bacteria,2GDAN@200918|Thermotogae	200918|Thermotogae	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_4521172_2	595537.Varpa_2255	2.605e-28	120.0	COG2030@1|root,COG2030@2|Bacteria,1RD6F@1224|Proteobacteria,2VTTS@28216|Betaproteobacteria,4AEPU@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM MaoC domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS3_k127_4521172_1	1120973.AQXL01000133_gene1710	6.755e-29	121.0	COG2030@1|root,COG2030@2|Bacteria,1VGYS@1239|Firmicutes,4HJK1@91061|Bacilli	91061|Bacilli	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
TLS3_k127_4521172_4	589865.DaAHT2_0639	1.405e-09	61.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42M4Q@68525|delta/epsilon subdivisions,2WIYG@28221|Deltaproteobacteria,2MIGJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TLS3_k127_4524815_0	420662.Mpe_A2504	1.699e-67	231.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,1KJVM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	transport protein CorA	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
TLS3_k127_4524815_2	1286093.C266_18836	2.555e-30	124.0	COG3794@1|root,COG3794@2|Bacteria,1RH5A@1224|Proteobacteria,2VSEN@28216|Betaproteobacteria,1K851@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Domain of unknown function (DUF4399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4399
TLS3_k127_4524815_1	504472.Slin_3452	1.8e-37	143.0	COG3169@1|root,COG3169@2|Bacteria,4NQH4@976|Bacteroidetes,47QJ9@768503|Cytophagia	976|Bacteroidetes	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
TLS3_k127_4536090_1	1380394.JADL01000007_gene4489	2.889e-69	241.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,2JQJW@204441|Rhodospirillales	204441|Rhodospirillales	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS3_k127_4536090_0	227377.CBU_1360	1.019e-172	545.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1JCSM@118969|Legionellales	118969|Legionellales	O	Uncharacterized protein family (UPF0051)	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS3_k127_4538729_0	877418.ATWV01000003_gene650	1.353e-70	248.0	COG2114@1|root,COG2114@2|Bacteria,2J5GP@203691|Spirochaetes	2|Bacteria	T	guanylate cyclase catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_453926_0	177437.HRM2_20200	1.782e-81	286.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42NUK@68525|delta/epsilon subdivisions,2WKP4@28221|Deltaproteobacteria,2MPTN@213118|Desulfobacterales	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_4542421_0	1237149.C900_02676	1.162e-126	421.0	COG0659@1|root,COG0659@2|Bacteria,4NE9G@976|Bacteroidetes,47MPC@768503|Cytophagia	976|Bacteroidetes	P	COGs COG0659 Sulfate permease and related transporter (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TLS3_k127_4542882_2	981085.XP_010112161.1	1.173e-10	63.0	COG2346@1|root,2QRXE@2759|Eukaryota,37PXR@33090|Viridiplantae,3GCEI@35493|Streptophyta,4JF4H@91835|fabids	35493|Streptophyta	S	Group 2 truncated hemoglobin	GLB3	GO:0001666,GO:0003674,GO:0005344,GO:0006810,GO:0006950,GO:0008150,GO:0009628,GO:0009719,GO:0009725,GO:0009733,GO:0010033,GO:0015669,GO:0015671,GO:0015893,GO:0036293,GO:0042221,GO:0042493,GO:0050896,GO:0051179,GO:0051234,GO:0070482,GO:0140104	-	-	-	-	-	-	-	-	-	-	Bac_globin
TLS3_k127_4542882_0	1109445.AGSX01000043_gene385	5.298e-78	273.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1Z03X@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_4542882_1	1380391.JIAS01000012_gene4563	7.932e-31	132.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,2JR7W@204441|Rhodospirillales	204441|Rhodospirillales	CT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
TLS3_k127_4544522_0	330214.NIDE1868	0.0	1141.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae	40117|Nitrospirae	H	Pterin binding enzyme	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
TLS3_k127_455032_2	649638.Trad_2712	7.034e-06	51.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS3_k127_455032_0	234267.Acid_0183	2.404e-301	941.0	COG0243@1|root,COG0243@2|Bacteria,3Y2HB@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS3_k127_455032_1	563040.Saut_0733	7.84e-07	53.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,42QHG@68525|delta/epsilon subdivisions,2YN5C@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K07307	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3	-	-	DmsC,Fer4_11,Fer4_4
TLS3_k127_4550957_2	1168034.FH5T_05345	1.264e-27	112.0	COG0495@1|root,COG0495@2|Bacteria,4NE5K@976|Bacteroidetes,2FM7V@200643|Bacteroidia	976|Bacteroidetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,DUF559,tRNA-synt_1,tRNA-synt_1_2
TLS3_k127_4550957_0	1232410.KI421428_gene1038	3.878e-150	486.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43T9G@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	helicase superfamily c-terminal domain	rhlE-2	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS3_k127_4550957_1	1227739.Hsw_2767	4.617e-50	186.0	COG0604@1|root,COG0604@2|Bacteria,4NHHT@976|Bacteroidetes,47PEF@768503|Cytophagia	976|Bacteroidetes	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS3_k127_4558457_1	644076.SCH4B_4261	1.558e-12	68.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,4NAV5@97050|Ruegeria	28211|Alphaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
TLS3_k127_4558457_2	861299.J421_0907	2.085e-06	57.0	COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_4558457_0	342949.PNA2_1134	8.745e-32	134.0	COG0643@1|root,arCOG04403@2157|Archaea,2XSUS@28890|Euryarchaeota,243R5@183968|Thermococci	183968|Thermococci	T	Histidine Phosphotransfer domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
TLS3_k127_4558721_4	1517681.HW45_27780	3.16e-14	75.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XUQI@135623|Vibrionales	135623|Vibrionales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_4558721_5	1499685.CCFJ01000012_gene1884	3.947e-05	48.0	COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,4HB3T@91061|Bacilli,1ZCRU@1386|Bacillus	91061|Bacilli	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_4558721_1	234267.Acid_4959	3.178e-129	441.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y63K@57723|Acidobacteria	57723|Acidobacteria	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
TLS3_k127_4558721_3	1282356.H045_08110	4.7e-39	168.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YRDW@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_4558721_2	861299.J421_6162	3.407e-44	165.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
TLS3_k127_4558721_0	861299.J421_6163	6.948e-180	576.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg
TLS3_k127_4565205_0	945713.IALB_1512	7.431e-31	131.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iLJ478.TM1264	PBP_like_2
TLS3_k127_4567077_2	929703.KE386491_gene2621	4.941e-41	159.0	COG2197@1|root,COG2197@2|Bacteria,4NMX5@976|Bacteroidetes,47PYR@768503|Cytophagia	976|Bacteroidetes	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_4567077_0	118173.KB235914_gene1399	1.344e-93	348.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_4567077_1	1123229.AUBC01000010_gene3473	6.59e-51	191.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,3JTPM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	MA20_09645	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
TLS3_k127_4567077_3	235279.HH_0456	2.421e-20	93.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2YP5K@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	NT	protein-glutamate methylesterase	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
TLS3_k127_456786_0	402881.Plav_1670	1.746e-10	64.0	COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,2U7IG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS3_k127_4569447_0	1480694.DC28_03250	1.966e-132	432.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS3_k127_4569447_1	228410.NE0194	3.244e-86	302.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,372T4@32003|Nitrosomonadales	28216|Betaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TLS3_k127_4573926_1	68570.DC74_7055	4.235e-35	151.0	COG0488@1|root,COG0488@2|Bacteria,2GJHN@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_4573926_0	1254432.SCE1572_33175	1.624e-81	287.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter, ATP-binding protein	ybiT	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_4579426_0	1307761.L21SP2_2022	1.027e-64	234.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS3_k127_4581134_2	1336243.JAEA01000008_gene1094	5.146e-19	86.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria,1JV3B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_4581134_0	243276.TPANIC_0485	1.866e-42	175.0	COG2114@1|root,COG2972@1|root,COG2114@2|Bacteria,COG2972@2|Bacteria,2J5GP@203691|Spirochaetes	203691|Spirochaetes	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_4581134_3	635013.TherJR_1014	2.772e-06	51.0	COG2949@1|root,COG2949@2|Bacteria,1V1FP@1239|Firmicutes,24HBG@186801|Clostridia,261DH@186807|Peptococcaceae	186801|Clostridia	S	PFAM DUF218 domain	-	-	-	ko:K03748	-	-	-	-	ko00000	-	-	-	DUF218
TLS3_k127_4582786_0	1537715.JQFJ01000002_gene1076	2.823e-41	162.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2K0HZ@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
TLS3_k127_4583496_0	861299.J421_4089	1.917e-27	119.0	COG1680@1|root,COG1680@2|Bacteria,1ZUDD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_4583496_1	761193.Runsl_4029	5.258e-19	92.0	COG2207@1|root,COG2207@2|Bacteria,4NHEJ@976|Bacteroidetes,47MRE@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_4584197_0	1353529.M899_1968	4.652e-65	226.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,42M34@68525|delta/epsilon subdivisions,2MSKZ@213481|Bdellovibrionales,2WKJ6@28221|Deltaproteobacteria	213481|Bdellovibrionales	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS3_k127_4584197_1	608506.COB47_1993	4.584e-09	62.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,42FAD@68295|Thermoanaerobacterales	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
TLS3_k127_4584692_2	755732.Fluta_0093	3.948e-05	52.0	2E00E@1|root,32VPV@2|Bacteria,4NSNA@976|Bacteroidetes,1I4TQ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4584692_0	666681.M301_0689	2.998e-155	495.0	COG2301@1|root,COG2301@2|Bacteria,1Q91U@1224|Proteobacteria,2VJJY@28216|Betaproteobacteria,2KM2P@206350|Nitrosomonadales	206350|Nitrosomonadales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS3_k127_4584692_1	118168.MC7420_3331	2.336e-37	153.0	COG1226@1|root,COG1226@2|Bacteria,1G1YD@1117|Cyanobacteria,1H6ZR@1150|Oscillatoriales	1117|Cyanobacteria	P	'Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
TLS3_k127_4586233_0	1192034.CAP_4315	1.151e-67	257.0	COG1520@1|root,COG3055@1|root,COG1520@2|Bacteria,COG3055@2|Bacteria,1NI1E@1224|Proteobacteria,430IZ@68525|delta/epsilon subdivisions,2WW3C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
TLS3_k127_4586233_1	2340.JV46_02910	8.154e-07	56.0	2EIMJ@1|root,33CCU@2|Bacteria,1NMXZ@1224|Proteobacteria,1SHQA@1236|Gammaproteobacteria,1J797@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4586233_2	1117379.BABA_24030	1.624e-06	58.0	COG2374@1|root,COG3225@1|root,COG2374@2|Bacteria,COG3225@2|Bacteria,1UJUI@1239|Firmicutes,4I2BS@91061|Bacilli,1ZCHV@1386|Bacillus	91061|Bacilli	N	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,LTD
TLS3_k127_4587090_0	391625.PPSIR1_33354	2.434e-97	327.0	COG1028@1|root,COG1028@2|Bacteria,1REA0@1224|Proteobacteria	1224|Proteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_459297_0	190304.FN0223	7.103e-09	68.0	COG0658@1|root,COG0658@2|Bacteria,378SE@32066|Fusobacteria	32066|Fusobacteria	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence
TLS3_k127_4593642_0	765912.Thimo_0438	2.089e-73	262.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,1X2HJ@135613|Chromatiales	135613|Chromatiales	I	acyl-CoA dehydrogenase	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N,AcylCoA_dehyd_C
TLS3_k127_4593642_1	194439.CT1638	5.048e-40	153.0	COG0780@1|root,COG0780@2|Bacteria,1FE3V@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
TLS3_k127_4593642_2	1536770.R50345_04730	3.779e-20	92.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,4HA4G@91061|Bacilli,26RAZ@186822|Paenibacillaceae	91061|Bacilli	E	Glutamate synthase	gltA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS3_k127_4602246_1	215803.DB30_5158	7.398e-86	297.0	COG1697@1|root,COG1697@2|Bacteria	2|Bacteria	L	DNA topoisomerase VI subunit A	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4602246_0	215803.DB30_5159	1.051e-202	641.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2YUPX@29|Myxococcales	28221|Deltaproteobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS3_k127_4603929_1	83406.HDN1F_36680	1.573e-82	281.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1SK7D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
TLS3_k127_4603929_0	1218074.BAXZ01000009_gene2188	1.643e-171	548.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,1K0H7@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Amidase, hydantoinase carbamoylase family	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_4603929_2	439235.Dalk_1557	2.851e-21	102.0	COG1309@1|root,COG1309@2|Bacteria,1NJZH@1224|Proteobacteria	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_4604201_1	1487923.DP73_10880	2.063e-06	55.0	COG2332@1|root,COG2332@2|Bacteria,1VJ83@1239|Firmicutes,24W3E@186801|Clostridia,265YA@186807|Peptococcaceae	186801|Clostridia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS3_k127_4604201_0	945713.IALB_0615	1.89e-18	89.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.12	ko:K00694,ko:K00786	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_tranf_2_3
TLS3_k127_4616599_0	1249627.D779_0271	3.483e-152	502.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
TLS3_k127_4616599_1	130081.XP_005706530.1	3.072e-59	220.0	COG0464@1|root,COG1088@1|root,KOG0730@2759|Eukaryota,KOG0747@2759|Eukaryota	2759|Eukaryota	M	dTDP-glucose 4,6-dehydratase activity	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	AAA,CbiX,Epimerase
TLS3_k127_4639401_0	518766.Rmar_1108	9.737e-241	769.0	COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,1FJ48@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
TLS3_k127_464836_1	86416.Clopa_3616	4.658e-23	104.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,36F75@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_464836_0	338969.Rfer_0062	2.776e-129	421.0	COG1960@1|root,COG1960@2|Bacteria,1R15B@1224|Proteobacteria	1224|Proteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS3_k127_4651480_0	558169.AGAV01000005_gene2268	6.914e-54	199.0	COG3332@1|root,COG3332@2|Bacteria,1UYHE@1239|Firmicutes,4HCA1@91061|Bacilli	91061|Bacilli	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
TLS3_k127_4658952_0	1107311.Q767_01620	1.347e-27	129.0	COG3291@1|root,COG3386@1|root,COG5306@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5306@2|Bacteria,4PM1B@976|Bacteroidetes	976|Bacteroidetes	G	SPTR Cell surface protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4658952_2	1273538.G159_02615	2.481e-08	63.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,26DP7@186818|Planococcaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_4658952_1	756067.MicvaDRAFT_0832	1.307e-17	94.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1G4T5@1117|Cyanobacteria	1117|Cyanobacteria	U	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,Haemagg_act,HemolysinCabind
TLS3_k127_466_1	1123368.AUIS01000006_gene686	5.331e-84	284.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,2NCMV@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS3_k127_466_2	646529.Desaci_3535	5.35e-75	269.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_466_3	330214.NIDE3451	1.396e-24	117.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS3_k127_466_4	1282887.AUJG01000001_gene1740	2.219e-05	50.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia	186801|Clostridia	S	PFAM Uncharacterised BCR, COG1937	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS3_k127_466_0	485913.Krac_9403	1.015e-106	358.0	COG1364@1|root,COG1364@2|Bacteria,2G64K@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	-	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS3_k127_4668550_1	883114.HMPREF9709_00037	5.572e-54	196.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,22G3Z@1570339|Peptoniphilaceae	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS3_k127_4668550_0	94624.Bpet0352	2.409e-78	271.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,3T267@506|Alcaligenaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA_3	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS3_k127_4676564_2	1120985.AUMI01000015_gene1425	3.533e-23	105.0	COG0496@1|root,COG0496@2|Bacteria,1TS2T@1239|Firmicutes,4H4KU@909932|Negativicutes	909932|Negativicutes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
TLS3_k127_4676564_3	545695.TREAZ_0455	2.473e-10	70.0	COG0457@1|root,COG0457@2|Bacteria,2J6BA@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
TLS3_k127_4676564_1	391615.ABSJ01000055_gene1366	7.56e-38	153.0	COG2207@1|root,COG2207@2|Bacteria,1N70D@1224|Proteobacteria,1S9TN@1236|Gammaproteobacteria,1JBPK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_4676564_0	1121904.ARBP01000013_gene445	5.846e-143	469.0	COG1012@1|root,COG1012@2|Bacteria,4NGHD@976|Bacteroidetes,47KZA@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	alkH	-	1.2.1.3,1.2.1.68	ko:K00128,ko:K00154	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_4683516_1	396588.Tgr7_0896	1.657e-21	103.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1WWI0@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
TLS3_k127_4683516_2	755731.Clo1100_2007	5.73e-20	92.0	COG1923@1|root,COG1923@2|Bacteria,1VEGI@1239|Firmicutes,24QIM@186801|Clostridia,36KQP@31979|Clostridiaceae	186801|Clostridia	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
TLS3_k127_4683516_0	756272.Plabr_1016	2.266e-61	226.0	COG0836@1|root,COG0836@2|Bacteria,2IXAR@203682|Planctomycetes	203682|Planctomycetes	M	Mannose-1-phosphate guanylyltransferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS3_k127_4683516_3	279238.Saro_2928	5.2e-09	65.0	COG1595@1|root,COG1595@2|Bacteria,1N413@1224|Proteobacteria,2U89X@28211|Alphaproteobacteria,2KA3H@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_4717165_0	909663.KI867150_gene605	3.716e-46	180.0	COG1994@1|root,COG1994@2|Bacteria,1QZHR@1224|Proteobacteria,43CIT@68525|delta/epsilon subdivisions,2X7T2@28221|Deltaproteobacteria,2MRQV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
TLS3_k127_4717165_1	880074.BARVI_05195	3.462e-20	89.0	COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,2FNIS@200643|Bacteroidia,22X8D@171551|Porphyromonadaceae	976|Bacteroidetes	S	ATP-binding cassette protein, ChvD family	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_4717561_1	1499967.BAYZ01000082_gene1015	1.678e-24	107.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,Guanylate_cyc,HATPase_c,HisKA,PAS,PAS_3,Response_reg,SpoIIE
TLS3_k127_4717561_0	1150600.ADIARSV_1291	1.924e-30	129.0	COG2867@1|root,COG2867@2|Bacteria,4NNHS@976|Bacteroidetes,1ISH1@117747|Sphingobacteriia	976|Bacteroidetes	I	START domain	-	-	-	-	-	-	-	-	-	-	-	-	START
TLS3_k127_4726224_0	1408473.JHXO01000010_gene3664	2.09e-19	100.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia	976|Bacteroidetes	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
TLS3_k127_4726224_1	281090.Lxx16130	3.911e-06	50.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4FKS1@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1731)	-	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS3_k127_4738792_0	363253.LI0109	2.513e-05	57.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42T19@68525|delta/epsilon subdivisions,2WRWI@28221|Deltaproteobacteria,2MGGR@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
TLS3_k127_474133_0	96561.Dole_2799	2.381e-59	216.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2MKKR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Alpha beta hydrolase	agmH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS3_k127_474133_1	1408254.T458_03110	1.386e-35	140.0	COG3011@1|root,COG3011@2|Bacteria,1V7DJ@1239|Firmicutes,4HIUD@91061|Bacilli,26YKY@186822|Paenibacillaceae	91061|Bacilli	S	Thiol-disulfide oxidoreductase DCC	yuxK	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS3_k127_474149_0	357808.RoseRS_0954	2.601e-188	604.0	COG0028@1|root,COG0028@2|Bacteria,2G7NZ@200795|Chloroflexi	200795|Chloroflexi	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_4743500_5	251221.35210862	1.494e-17	89.0	COG0558@1|root,COG0558@2|Bacteria,1G4ZG@1117|Cyanobacteria	1117|Cyanobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iJN678.pgsA	CDP-OH_P_transf
TLS3_k127_4743500_0	1379858.N508_00617	1.792e-133	438.0	COG0104@1|root,COG0104@2|Bacteria,2GEUU@200930|Deferribacteres	200930|Deferribacteres	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS3_k127_4743500_4	1134413.ANNK01000076_gene3419	1.061e-25	113.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,4HIR4@91061|Bacilli,1ZGBF@1386|Bacillus	91061|Bacilli	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS3_k127_4743500_6	1449050.JNLE01000005_gene4408	0.0007422	51.0	COG3292@1|root,COG3469@1|root,COG3979@1|root,COG3292@2|Bacteria,COG3469@2|Bacteria,COG3979@2|Bacteria,1TQIF@1239|Firmicutes,24CZT@186801|Clostridia,36GF7@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 18 family	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18
TLS3_k127_4743500_2	1121920.AUAU01000009_gene1861	3.759e-67	244.0	COG3437@1|root,COG3437@2|Bacteria,3Y2TI@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
TLS3_k127_4743500_3	1026882.MAMP_01676	1.121e-28	120.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,462JU@72273|Thiotrichales	72273|Thiotrichales	KT	response regulator receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS3_k127_4743500_1	1120934.KB894432_gene6140	2.026e-106	374.0	COG0643@1|root,COG0643@2|Bacteria,2IBKY@201174|Actinobacteria,4E8F7@85010|Pseudonocardiales	201174|Actinobacteria	T	Signal transducing histidine kinase, homodimeric domain	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
TLS3_k127_4745198_3	1173029.JH980292_gene76	0.000148	51.0	COG0457@1|root,COG0457@2|Bacteria,1G1G9@1117|Cyanobacteria,1H889@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
TLS3_k127_4745198_0	314264.ROS217_00500	1.432e-115	390.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,46RSG@74030|Roseovarius	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS3_k127_4745198_1	638301.HMPREF0444_1805	1.537e-52	190.0	COG1051@1|root,COG1051@2|Bacteria,1V9FN@1239|Firmicutes,4HHZ1@91061|Bacilli,27HIM@186828|Carnobacteriaceae	91061|Bacilli	F	NUDIX domain	mutX	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS3_k127_4745198_2	1313172.YM304_12950	9.619e-49	192.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4CMRN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
TLS3_k127_4748232_0	195250.CM001776_gene2837	0.0007508	51.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,RHS_repeat,VCBS
TLS3_k127_4755011_0	1449336.JQLO01000001_gene2214	1.934e-47	180.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,4HAYM@91061|Bacilli,27FCJ@186828|Carnobacteriaceae	91061|Bacilli	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	soj	GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS3_k127_4755011_1	1296990.H845_1092	1.571e-08	68.0	COG0823@1|root,COG0823@2|Bacteria,1R6I6@1224|Proteobacteria,2UPB6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
TLS3_k127_47573_0	28444.JODQ01000014_gene6984	2.874e-15	87.0	COG2133@1|root,COG3291@1|root,COG3507@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3507@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria,4EKGY@85012|Streptosporangiales	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1349,F5_F8_type_C,GSDH,PKD,Ricin_B_lectin,ThuA
TLS3_k127_4757385_0	656519.Halsa_2359	2.101e-52	191.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3WB27@53433|Halanaerobiales	186801|Clostridia	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_4757385_1	1480694.DC28_06805	1.139e-11	75.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS3_k127_4758269_3	1145276.T479_09050	4.415e-05	57.0	COG1361@1|root,COG3210@1|root,COG5492@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1VBWG@1239|Firmicutes,4ITWA@91061|Bacilli,3IZ5A@400634|Lysinibacillus	91061|Bacilli	MN	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,Cadherin_3,Flg_new,SLH
TLS3_k127_4758269_2	1449355.JQNR01000005_gene3203	3.348e-05	57.0	COG2273@1|root,COG2273@2|Bacteria,2GKFN@201174|Actinobacteria	201174|Actinobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C
TLS3_k127_4758269_1	391625.PPSIR1_02653	6.333e-45	186.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF637,Haemagg_act,He_PIG,Peptidase_S74,REJ,SprB
TLS3_k127_4758269_0	880073.Calab_3484	4.515e-116	384.0	COG3842@1|root,COG3842@2|Bacteria,2NNU0@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS3_k127_4760673_0	717785.HYPMC_3863	1.487e-54	203.0	COG3832@1|root,COG3832@2|Bacteria,1RJ7U@1224|Proteobacteria,2U9W0@28211|Alphaproteobacteria,3N93U@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_4760673_1	1192759.AKIB01000009_gene2549	4.314e-45	167.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,2K5Z8@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
TLS3_k127_4762040_0	404380.Gbem_1336	4.926e-122	408.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
TLS3_k127_4763101_1	448385.sce8687	9.785e-19	96.0	COG2267@1|root,COG2267@2|Bacteria,1QX85@1224|Proteobacteria,42W1M@68525|delta/epsilon subdivisions,2WR6V@28221|Deltaproteobacteria,2YUZN@29|Myxococcales	28221|Deltaproteobacteria	I	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS3_k127_4763101_0	1246459.KB898358_gene3813	7.505e-32	141.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2U0G1@28211|Alphaproteobacteria,4BC7K@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
TLS3_k127_4766010_0	1348583.ATLH01000009_gene3282	2.532e-25	115.0	2DHHK@1|root,2ZZTA@2|Bacteria,4PG4J@976|Bacteroidetes,1IJEA@117743|Flavobacteriia,1FA3H@104264|Cellulophaga	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4766010_1	866536.Belba_2373	2.61e-07	53.0	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS3_k127_47695_0	744872.Spica_0771	4.21e-97	331.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS3_k127_47695_1	665571.STHERM_c07250	4.361e-25	108.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
TLS3_k127_4771889_0	1233951.IO90_05390	3.741e-24	114.0	COG1835@1|root,COG1835@2|Bacteria,4NMNZ@976|Bacteroidetes,1HXKH@117743|Flavobacteriia,3HH4I@358033|Chryseobacterium	976|Bacteroidetes	I	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
TLS3_k127_4771889_1	1029824.AFID01000002_gene1629	1.39e-12	76.0	COG2039@1|root,COG2039@2|Bacteria,2GN39@201174|Actinobacteria,1W9TX@1268|Micrococcaceae	201174|Actinobacteria	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
TLS3_k127_477320_0	497964.CfE428DRAFT_1504	8.247e-36	148.0	COG3391@1|root,COG4733@1|root,COG3391@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,NHL,SprB
TLS3_k127_4791448_1	1403819.BATR01000002_gene96	8.718e-12	71.0	COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria,46UNM@74201|Verrucomicrobia,2IVJ3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Passenger-associated-transport-repeat	-	-	-	-	-	-	-	-	-	-	-	-	PATR
TLS3_k127_4791448_0	521674.Plim_1493	5.566e-194	617.0	COG2308@1|root,COG2308@2|Bacteria,2IXE6@203682|Planctomycetes	203682|Planctomycetes	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
TLS3_k127_4792319_0	296591.Bpro_4702	6.103e-171	546.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VK5V@28216|Betaproteobacteria,4AAPR@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS3_k127_480847_1	32049.SYNPCC7002_A2455	6.14e-26	109.0	COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,1GYMC@1129|Synechococcus	1117|Cyanobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS3_k127_480847_0	179408.Osc7112_1555	3.128e-57	210.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG2770@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
TLS3_k127_480952_0	1480694.DC28_10570	1.556e-33	147.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
TLS3_k127_4818235_0	1333507.AUTQ01000069_gene2156	1.146e-07	59.0	COG5184@1|root,COG5184@2|Bacteria,1R0KM@1224|Proteobacteria,1T4JW@1236|Gammaproteobacteria,2Q1PE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	DZ	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	LTD
TLS3_k127_482384_2	314285.KT71_02392	0.0006436	46.0	29GUQ@1|root,2ZIQ9@2|Bacteria,1P89M@1224|Proteobacteria,1STDV@1236|Gammaproteobacteria,1JBAC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS3_k127_482384_0	1125863.JAFN01000001_gene3470	2.573e-31	132.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42S9F@68525|delta/epsilon subdivisions,2WN90@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_4830661_0	1191523.MROS_1342	3.002e-150	479.0	COG0031@1|root,COG0031@2|Bacteria	2|Bacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_4835880_2	1123256.KB907959_gene491	0.0003659	50.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,1SAXC@1236|Gammaproteobacteria,1X7M9@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
TLS3_k127_4835880_0	1157490.EL26_03260	5.29e-139	456.0	COG4320@1|root,COG4320@2|Bacteria,1UCBA@1239|Firmicutes,4HBCI@91061|Bacilli	91061|Bacilli	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	DUF2252
TLS3_k127_4835880_1	929556.Solca_3386	5.283e-56	202.0	COG1192@1|root,COG1192@2|Bacteria,4P219@976|Bacteroidetes,1IVJM@117747|Sphingobacteriia	976|Bacteroidetes	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
TLS3_k127_4839248_1	754027.HMPREF9554_03137	6.978e-12	78.0	COG4254@1|root,COG4254@2|Bacteria,2J6MW@203691|Spirochaetes	203691|Spirochaetes	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS3_k127_4839248_0	221027.JO40_09200	1.888e-77	265.0	COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,2J5GP@203691|Spirochaetes	203691|Spirochaetes	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_4841673_0	459495.SPLC1_S540080	2.655e-131	425.0	COG0610@1|root,COG0610@2|Bacteria,1G3YH@1117|Cyanobacteria,1HA5G@1150|Oscillatoriales	1117|Cyanobacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
TLS3_k127_4841673_1	1162668.LFE_0359	8.495e-82	278.0	COG0610@1|root,COG0610@2|Bacteria,3J0QC@40117|Nitrospirae	40117|Nitrospirae	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
TLS3_k127_4841673_2	452637.Oter_2969	3.988e-68	239.0	COG3696@1|root,COG3696@2|Bacteria,46USJ@74201|Verrucomicrobia,3K96P@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
TLS3_k127_4858345_0	1347342.BN863_35320	2.408e-09	64.0	COG2227@1|root,COG2227@2|Bacteria,4NGVF@976|Bacteroidetes,1HXGK@117743|Flavobacteriia	976|Bacteroidetes	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS3_k127_4858345_1	1122212.AULO01000007_gene2337	0.0009222	42.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,1XHIN@135619|Oceanospirillales	135619|Oceanospirillales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.68	ko:K00154	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
TLS3_k127_4864765_0	709797.CSIRO_0741	2.126e-112	382.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JR0R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_4864765_1	1121405.dsmv_1861	3.743e-91	308.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,PTS_EIIA_2
TLS3_k127_4865154_0	1444310.JANV01000086_gene137	1.569e-19	94.0	COG1843@1|root,COG1843@2|Bacteria,1VF85@1239|Firmicutes,4HH9I@91061|Bacilli,1ZQRG@1386|Bacillus	91061|Bacilli	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
TLS3_k127_4865159_0	1340493.JNIF01000003_gene2009	1.797e-31	128.0	COG1232@1|root,COG1232@2|Bacteria,3Y3KX@57723|Acidobacteria	57723|Acidobacteria	H	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS3_k127_4865159_2	375286.mma_2228	1.468e-06	55.0	COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VW90@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
TLS3_k127_4865159_1	761193.Runsl_0759	4.033e-18	86.0	COG4095@1|root,COG4095@2|Bacteria,4NUQW@976|Bacteroidetes,47R6D@768503|Cytophagia	976|Bacteroidetes	S	Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins.	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
TLS3_k127_4873752_2	1550091.JROE01000004_gene1918	6.777e-05	50.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IP7Q@117747|Sphingobacteriia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,PDZ_2,Peptidase_S41,Tricorn_C1
TLS3_k127_4873752_0	1337936.IJ00_05970	2.678e-54	202.0	COG0300@1|root,COG0300@2|Bacteria,1G1Z0@1117|Cyanobacteria,1HR28@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_4873752_1	1191460.F959_01111	7.712e-35	143.0	2B1M2@1|root,31U2I@2|Bacteria,1QRW3@1224|Proteobacteria,1RV37@1236|Gammaproteobacteria,3NJCR@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4880259_0	1267535.KB906767_gene3587	2.511e-43	179.0	COG2373@1|root,COG2373@2|Bacteria,3Y439@57723|Acidobacteria,2JMCS@204432|Acidobacteriia	204432|Acidobacteriia	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
TLS3_k127_4881612_1	765869.BDW_09805	1.329e-10	64.0	COG0204@1|root,COG0204@2|Bacteria,1N01J@1224|Proteobacteria,42UM7@68525|delta/epsilon subdivisions,2MURH@213481|Bdellovibrionales,2WQN9@28221|Deltaproteobacteria	213481|Bdellovibrionales	I	PFAM phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS3_k127_4881612_2	1122622.ATWJ01000007_gene1988	2.724e-08	61.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria,4FGZ4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS3_k127_4881612_0	349161.Dred_2376	2.233e-47	177.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,261JF@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS3_k127_4881612_3	1408436.JHXY01000014_gene1707	0.0005692	43.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,25X7S@186806|Eubacteriaceae	186801|Clostridia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS3_k127_4888597_0	502025.Hoch_1557	6.708e-106	354.0	COG2936@1|root,COG2936@2|Bacteria,1QX6I@1224|Proteobacteria,42YCU@68525|delta/epsilon subdivisions,2WTXJ@28221|Deltaproteobacteria,2YTZE@29|Myxococcales	28221|Deltaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
TLS3_k127_4905806_1	868864.Dester_0870	7.731e-93	323.0	COG0739@1|root,COG4413@1|root,COG0739@2|Bacteria,COG4413@2|Bacteria,2G3U6@200783|Aquificae	200783|Aquificae	EM	Urea transporter	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,UT
TLS3_k127_4905806_0	648996.Theam_0938	5.375e-147	480.0	COG0019@1|root,COG0019@2|Bacteria,2G3VG@200783|Aquificae	200783|Aquificae	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS3_k127_4905806_2	1123057.P872_15940	2.37e-80	281.0	COG0151@1|root,COG0151@2|Bacteria,4NK50@976|Bacteroidetes,47TMM@768503|Cytophagia	976|Bacteroidetes	F	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
TLS3_k127_4905806_4	1158318.ATXC01000001_gene638	1.26e-14	79.0	2EBCA@1|root,335D0@2|Bacteria	2|Bacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
TLS3_k127_4905806_5	1194972.MVAC_04292	1.371e-09	63.0	COG1366@1|root,COG1366@2|Bacteria,2HS26@201174|Actinobacteria,23A7D@1762|Mycobacteriaceae	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
TLS3_k127_4905806_3	1480694.DC28_10570	5.845e-36	154.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
TLS3_k127_4907951_0	439235.Dalk_5164	5.189e-65	229.0	2FCUT@1|root,344XR@2|Bacteria,1P20K@1224|Proteobacteria,4320S@68525|delta/epsilon subdivisions,2WWIJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4907951_1	7213.XP_004521050.1	8.983e-18	88.0	COG1324@1|root,KOG3338@2759|Eukaryota,3A1S2@33154|Opisthokonta,3BQH3@33208|Metazoa,3D77M@33213|Bilateria,41ZVP@6656|Arthropoda,3SN39@50557|Insecta,453SD@7147|Diptera	33208|Metazoa	P	It is involved in the biological process described with response to metal ion	CUTA	GO:0003674,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0008104,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0019899,GO:0022607,GO:0033036,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046914,GO:0051179,GO:0051259,GO:0051260,GO:0065003,GO:0071840	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS3_k127_4911867_0	1038859.AXAU01000009_gene1537	1.947e-58	213.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JTUH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
TLS3_k127_4911867_1	272123.Anacy_2550	5.472e-16	81.0	COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1GDIS@1117|Cyanobacteria,1HMME@1161|Nostocales	1117|Cyanobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
TLS3_k127_4913441_0	1237149.C900_04178	3.854e-16	85.0	2DS7J@1|root,33EW7@2|Bacteria,4PPYB@976|Bacteroidetes,47YSS@768503|Cytophagia	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
TLS3_k127_4913441_2	1415779.JOMH01000001_gene2217	0.0002535	46.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_4913441_1	946483.Cenrod_0264	1.31e-15	83.0	COG1262@1|root,COG2340@1|root,COG1262@2|Bacteria,COG2340@2|Bacteria,1R21A@1224|Proteobacteria,2WI7Q@28216|Betaproteobacteria,4AG4G@80864|Comamonadaceae	1224|Proteobacteria	S	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
TLS3_k127_4938034_0	62977.ACIAD0606	6.567e-18	94.0	2940W@1|root,2ZRFQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4938034_1	639030.JHVA01000001_gene652	1.639e-14	78.0	COG2050@1|root,COG2050@2|Bacteria,3Y57I@57723|Acidobacteria,2JJU4@204432|Acidobacteriia	204432|Acidobacteriia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_4938160_0	402777.KB235903_gene1652	1.137e-89	304.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G4ED@1117|Cyanobacteria,1HA0Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,Guanylate_cyc
TLS3_k127_4938160_1	1502724.FF80_00216	3.734e-46	173.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,3N61F@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	MA20_36195	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
TLS3_k127_4941915_0	545695.TREAZ_3129	0.0005129	52.0	2F58Y@1|root,33W1Y@2|Bacteria,2JBFR@203691|Spirochaetes	203691|Spirochaetes	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1577,PilZ
TLS3_k127_4949470_0	1121904.ARBP01000002_gene6918	4.427e-104	349.0	COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,47UE3@768503|Cytophagia	976|Bacteroidetes	S	ABC transporter C-terminal domain	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS3_k127_4953125_0	1123288.SOV_3c03780	9.513e-27	121.0	COG1560@1|root,COG1560@2|Bacteria,1U76T@1239|Firmicutes,4H2PH@909932|Negativicutes	909932|Negativicutes	M	Lipid A biosynthesis	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS3_k127_4953279_1	1449345.JHWC01000001_gene66	2.051e-24	116.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2YNFC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TLS3_k127_4953279_0	1304885.AUEY01000059_gene2412	1.039e-159	517.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MHMB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS3_k127_4966473_0	96561.Dole_1921	4.707e-180	572.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,42NKV@68525|delta/epsilon subdivisions,2WKPA@28221|Deltaproteobacteria,2MIDW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_4966473_1	518766.Rmar_1382	3.753e-41	159.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
TLS3_k127_4966473_2	1317124.DW2_04244	1.201e-38	147.0	COG1073@1|root,COG1073@2|Bacteria,1PIRI@1224|Proteobacteria,2V9I0@28211|Alphaproteobacteria,2XPAN@285107|Thioclava	28211|Alphaproteobacteria	S	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4996375_0	744872.Spica_2526	2.602e-32	134.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2JBDH@203691|Spirochaetes	2|Bacteria	KT	7TM diverse intracellular signalling	rsbW	-	2.4.1.12,3.1.3.3	ko:K00694,ko:K07315,ko:K20977	ko00500,ko01100,ko02020,ko02025,ko02026,map00500,map01100,map02020,map02025,map02026	M00820	R02889	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02022,ko03021	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	HATPase_c_2,MatE,SpoIIE
TLS3_k127_4996375_1	1313172.YM304_00530	2.11e-14	87.0	COG0584@1|root,COG1361@1|root,COG3291@1|root,COG3897@1|root,COG5184@1|root,COG0584@2|Bacteria,COG1361@2|Bacteria,COG3291@2|Bacteria,COG3897@2|Bacteria,COG5184@2|Bacteria,2GTZZ@201174|Actinobacteria	201174|Actinobacteria	CDZ	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5022324_0	1519464.HY22_00465	2.494e-21	103.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
TLS3_k127_5026717_0	991.IW20_02315	6.361e-61	217.0	COG0377@1|root,COG0377@2|Bacteria,4NFKT@976|Bacteroidetes,1I0R8@117743|Flavobacteriia,2NSHX@237|Flavobacterium	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
TLS3_k127_5026717_1	1123277.KB893178_gene2554	1.046e-26	115.0	COG0838@1|root,COG0838@2|Bacteria,4NQJB@976|Bacteroidetes,47Q47@768503|Cytophagia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS3_k127_5041409_0	497964.CfE428DRAFT_5364	2.847e-06	57.0	COG1366@1|root,COG1366@2|Bacteria,46T72@74201|Verrucomicrobia	74201|Verrucomicrobia	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
TLS3_k127_5051235_0	1125863.JAFN01000001_gene3585	8.325e-110	365.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS3_k127_5051235_1	880071.Fleli_1354	6.106e-17	94.0	COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47NFW@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,TPR_12
TLS3_k127_5051843_3	314345.SPV1_02432	2.479e-21	98.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,MASE4,PAS,PAS_3,PAS_9,Response_reg,dCache_1
TLS3_k127_5051843_0	1112274.KI911560_gene2424	7.404e-120	396.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KMFD@206350|Nitrosomonadales	206350|Nitrosomonadales	T	HD domain	-	-	-	ko:K07814,ko:K13815	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HD,HD_5,Response_reg
TLS3_k127_5051843_2	1112274.KI911560_gene2425	1.579e-40	153.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VVWD@28216|Betaproteobacteria,2KPBH@206350|Nitrosomonadales	206350|Nitrosomonadales	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_5051843_1	1123508.JH636441_gene3711	1.201e-79	294.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_3,Response_reg
TLS3_k127_5051843_4	1122978.AUFP01000006_gene1708	1.408e-11	70.0	COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,2FMJH@200643|Bacteroidia	976|Bacteroidetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	srrA	-	-	ko:K07657,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_5062416_0	760568.Desku_1799	9.485e-07	55.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_5070229_0	1249627.D779_0334	1.087e-91	317.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales	135613|Chromatiales	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TLS3_k127_5074212_2	883156.HMPREF9282_00211	2.77e-23	114.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4H1X4@909932|Negativicutes	909932|Negativicutes	D	FtsK SpoIIIE family protein	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS3_k127_5074212_1	868864.Dester_0328	2.766e-30	132.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,2G44W@200783|Aquificae	200783|Aquificae	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
TLS3_k127_5074212_0	227377.CBU_0620	1.353e-55	211.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1JDAY@118969|Legionellales	118969|Legionellales	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS3_k127_5079431_0	1120956.JHZK01000006_gene631	4.762e-50	194.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JPCC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	crtI	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016119,GO:0016120,GO:0016491,GO:0016627,GO:0036094,GO:0042214,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046246,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13	ko:K09835,ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04787,R04798,R04800,R07512,R09691,R09692	RC01214,RC01960,RC02088,RC02605	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS3_k127_5083257_1	740709.A10D4_06271	3.609e-07	56.0	COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,1S9QR@1236|Gammaproteobacteria,2QG8B@267893|Idiomarinaceae	1236|Gammaproteobacteria	T	Anti-anti-sigma regulatory factor	-	-	-	ko:K20978	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001	-	-	-	STAS,STAS_2
TLS3_k127_5083257_0	517418.Ctha_1069	2.128e-23	108.0	COG2832@1|root,COG2832@2|Bacteria	2|Bacteria	F	Protein of unknown function (DUF454)	ybaN	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
TLS3_k127_5089696_0	1005995.GTPT_0337	1.082e-13	78.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,4BUAV@82986|Tatumella	1236|Gammaproteobacteria	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
TLS3_k127_5090292_0	1173028.ANKO01000159_gene5164	1.4e-115	382.0	COG1162@1|root,COG1162@2|Bacteria,1G18W@1117|Cyanobacteria,1H9XI@1150|Oscillatoriales	1117|Cyanobacteria	S	RsgA GTPase	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS3_k127_5090292_1	1517682.HW49_02120	0.0008826	50.0	28MSN@1|root,2ZB0Y@2|Bacteria,4NHW7@976|Bacteroidetes,2FX00@200643|Bacteroidia,22ZC2@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VIT
TLS3_k127_509200_0	1379270.AUXF01000004_gene3200	3.849e-91	312.0	COG1680@1|root,COG1680@2|Bacteria,1ZUDD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_509200_1	1296415.JACC01000002_gene3223	2.914e-19	90.0	COG0477@1|root,COG2814@2|Bacteria,4NUYS@976|Bacteroidetes,1I53U@117743|Flavobacteriia,2YJTB@290174|Aquimarina	976|Bacteroidetes	EGP	Domain of unknown function (DUF3817)	ydzA	-	-	-	-	-	-	-	-	-	-	-	DUF3817
TLS3_k127_509200_2	223184.AS25_04380	4.115e-10	70.0	COG0204@1|root,COG0204@2|Bacteria,2GQVG@201174|Actinobacteria,1WCIB@1268|Micrococcaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_5095094_1	1121904.ARBP01000004_gene803	2.624e-96	332.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	ndh	-	1.6.99.3	ko:K03885,ko:K10716	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Abhydrolase_6,Ion_trans,Pyr_redox_2,cNMP_binding
TLS3_k127_5095094_0	189425.PGRAT_14725	1.473e-173	574.0	COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae	91061|Bacilli	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
TLS3_k127_5095094_2	1200557.JHWV01000006_gene1862	0.00014	53.0	COG2208@1|root,COG5000@1|root,COG2208@2|Bacteria,COG5000@2|Bacteria,1TQY5@1239|Firmicutes,4H4HJ@909932|Negativicutes	909932|Negativicutes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
TLS3_k127_5097145_2	643648.Slip_0013	1.32e-06	56.0	COG2402@1|root,COG2402@2|Bacteria,1VFYF@1239|Firmicutes,24RM2@186801|Clostridia	186801|Clostridia	S	contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_5097145_0	391625.PPSIR1_23629	5.056e-45	174.0	COG3687@1|root,COG3687@2|Bacteria,1R4HJ@1224|Proteobacteria	1224|Proteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
TLS3_k127_5099576_5	1217714.F975_00887	2.199e-14	79.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,1SYVW@1236|Gammaproteobacteria,3NTBE@468|Moraxellaceae	1236|Gammaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS3_k127_5099576_4	889378.Spiaf_0608	1.486e-26	114.0	COG1406@1|root,COG1406@2|Bacteria,2JAIP@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
TLS3_k127_5099576_1	906968.Trebr_0195	3.365e-41	156.0	COG1406@1|root,COG1406@2|Bacteria,2JAIP@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
TLS3_k127_5099576_3	889378.Spiaf_0607	4.446e-37	143.0	COG2201@1|root,COG2201@2|Bacteria,2JAI9@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS3_k127_5099576_0	1485545.JQLW01000006_gene358	4.462e-49	182.0	COG5514@1|root,COG5514@2|Bacteria,1MX90@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF1794)	MA20_21045	-	-	-	-	-	-	-	-	-	-	-	DUF1794
TLS3_k127_5099576_2	1538644.KO02_07585	1.106e-38	151.0	COG2353@1|root,COG2353@2|Bacteria,4NMFT@976|Bacteroidetes,1ISZV@117747|Sphingobacteriia	976|Bacteroidetes	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS3_k127_5102839_0	1218075.BAYA01000001_gene262	1.98e-132	426.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,1K4T4@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the malate synthase family	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
TLS3_k127_5102839_3	1380600.AUYN01000007_gene3147	0.0004557	49.0	COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,4NHRP@976|Bacteroidetes,1HXVY@117743|Flavobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
TLS3_k127_5102839_1	862908.BMS_0649	2.901e-57	208.0	COG3148@1|root,COG3148@2|Bacteria,1MZCN@1224|Proteobacteria,42S7K@68525|delta/epsilon subdivisions,2MU2H@213481|Bdellovibrionales,2WQI0@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	DTW	-	-	-	ko:K05812	-	-	-	-	ko00000	-	-	-	DTW
TLS3_k127_5102839_2	405948.SACE_6735	1.689e-27	115.0	COG2351@1|root,COG2351@2|Bacteria,2IQUN@201174|Actinobacteria,4E5V4@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
TLS3_k127_5112191_0	1304885.AUEY01000054_gene169	0.0001224	52.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42P32@68525|delta/epsilon subdivisions,2WM9Q@28221|Deltaproteobacteria,2MISR@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TLS3_k127_5118169_0	889378.Spiaf_0527	1.351e-39	161.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	2|Bacteria	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
TLS3_k127_5118169_1	1408473.JHXO01000012_gene317	2.22e-15	77.0	COG0842@1|root,COG0842@2|Bacteria,4NKB0@976|Bacteroidetes,2FW5E@200643|Bacteroidia	976|Bacteroidetes	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
TLS3_k127_512549_2	1408422.JHYF01000002_gene2617	4.305e-21	94.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,36IRH@31979|Clostridiaceae	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS3_k127_512549_1	502025.Hoch_2147	1.94e-42	175.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2YVAG@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS3_k127_512549_0	1120970.AUBZ01000001_gene3642	2.209e-62	222.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,466E9@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TLS3_k127_512549_3	485915.Dret_2233	7.699e-08	56.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2M7ZM@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS3_k127_5129902_1	1232410.KI421413_gene485	1.371e-24	108.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42Q9U@68525|delta/epsilon subdivisions,2X5CC@28221|Deltaproteobacteria,43UFH@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS3_k127_5129902_0	56780.SYN_02346	1.177e-88	302.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42Q9U@68525|delta/epsilon subdivisions,2X5CC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS3_k127_5132774_0	1242864.D187_007533	6.78e-53	199.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42SWK@68525|delta/epsilon subdivisions,2WPU0@28221|Deltaproteobacteria,2YUSY@29|Myxococcales	28221|Deltaproteobacteria	H	tRNA nucleotidyltransferase domain 2 putative	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS3_k127_5134004_2	1232410.KI421415_gene3091	4.954e-10	60.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS_4
TLS3_k127_5134004_1	864702.OsccyDRAFT_2899	3.908e-29	134.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H97F@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS_4,Response_reg
TLS3_k127_5134004_0	864702.OsccyDRAFT_3160	1.073e-51	205.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HABM@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS3_k127_5137518_0	1304885.AUEY01000048_gene611	3.859e-35	139.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,42N54@68525|delta/epsilon subdivisions,2WMGU@28221|Deltaproteobacteria,2MI8K@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TLS3_k127_5137518_1	765869.BDW_07665	1.2e-26	121.0	COG1651@1|root,COG4243@1|root,COG1651@2|Bacteria,COG4243@2|Bacteria,1QSA7@1224|Proteobacteria,42T4Y@68525|delta/epsilon subdivisions,2MTAB@213481|Bdellovibrionales,2WPNT@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	Thiol disulfide interchange protein dsbA	-	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4,VKOR
TLS3_k127_5140315_0	1234679.BN424_785	2.328e-64	225.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli,27FZY@186828|Carnobacteriaceae	91061|Bacilli	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS3_k127_5140435_1	592028.GCWU000321_00650	0.0005731	50.0	COG0795@1|root,COG0795@2|Bacteria,1TRZG@1239|Firmicutes,4H2PV@909932|Negativicutes	909932|Negativicutes	S	Permease, YjgP YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS3_k127_5140435_0	648996.Theam_1479	3.58e-64	226.0	COG1260@1|root,COG1260@2|Bacteria,2G3U0@200783|Aquificae	200783|Aquificae	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS3_k127_5145290_4	1298863.AUEP01000019_gene3507	2.258e-09	64.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,4DNH5@85009|Propionibacteriales	201174|Actinobacteria	K	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
TLS3_k127_5145290_0	156889.Mmc1_1773	1.825e-75	268.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
TLS3_k127_5145290_2	383372.Rcas_3382	7.524e-55	212.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi,375DV@32061|Chloroflexia	32061|Chloroflexia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS3_k127_5145290_1	648996.Theam_0744	5.801e-67	247.0	COG1008@1|root,COG1008@2|Bacteria,2G3VS@200783|Aquificae	200783|Aquificae	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS3_k127_5145290_3	1432055.GLUCORHAEAF1_05780	2.41e-11	70.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2JPUQ@204441|Rhodospirillales	204441|Rhodospirillales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
TLS3_k127_515130_2	1157490.EL26_05980	3.006e-58	206.0	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,4H9WM@91061|Bacilli,278XJ@186823|Alicyclobacillaceae	91061|Bacilli	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS3_k127_515130_3	479434.Sthe_1410	3.128e-39	155.0	COG0755@1|root,COG0755@2|Bacteria,2G6SI@200795|Chloroflexi,27Y6D@189775|Thermomicrobia	189775|Thermomicrobia	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS3_k127_515130_0	1537915.JU57_10190	6.869e-130	420.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2YNAJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS3_k127_515130_1	1347342.BN863_35160	6.826e-63	221.0	COG1898@1|root,COG1898@2|Bacteria,4NNKW@976|Bacteroidetes,1I20V@117743|Flavobacteriia	976|Bacteroidetes	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS3_k127_515130_4	637389.Acaty_c0414	5.147e-15	77.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,2NCIE@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS3_k127_5151816_0	1121430.JMLG01000002_gene1008	3.363e-12	71.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25ZYN@186807|Peptococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS3_k127_5154312_0	889378.Spiaf_1632	6.642e-105	351.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS3_k127_5154312_1	1121472.AQWN01000008_gene1965	4.587e-52	188.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,260HH@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	yugH	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_5156318_0	1480694.DC28_03670	3.401e-97	323.0	COG0379@1|root,COG0379@2|Bacteria,2JAE2@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS3_k127_5171864_1	485918.Cpin_1121	3.995e-57	206.0	COG1670@1|root,COG1670@2|Bacteria,4NNBE@976|Bacteroidetes,1IS72@117747|Sphingobacteriia	976|Bacteroidetes	J	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_5171864_0	1434325.AZQN01000001_gene99	7.85e-71	246.0	COG0221@1|root,COG0221@2|Bacteria,4NGBU@976|Bacteroidetes,47M21@768503|Cytophagia	976|Bacteroidetes	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
TLS3_k127_5171864_2	1192034.CAP_2342	2.06e-33	135.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter, ATP-binding protein	ybiT	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_5180415_1	706587.Desti_3021	5.928e-43	163.0	COG2202@1|root,COG2204@1|root,COG3850@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_5180415_0	1220534.B655_2429	9.699e-111	389.0	COG0784@1|root,arCOG02348@1|root,arCOG02350@1|root,arCOG06712@1|root,arCOG02348@2157|Archaea,arCOG02350@2157|Archaea,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea,2XYJJ@28890|Euryarchaeota	28890|Euryarchaeota	T	Pas domain s-box	-	-	-	-	-	-	-	-	-	-	-	-	DUF835,HAMP,HATPase_c,PAS,PAS_9
TLS3_k127_5180415_2	288000.BBta_5830	2.461e-05	49.0	2FFDN@1|root,347B9@2|Bacteria,1N3AI@1224|Proteobacteria,2TUEQ@28211|Alphaproteobacteria,3JTK2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5190126_0	870187.Thini_3083	3.435e-34	142.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1RPXT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	yafK	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS3_k127_5192931_0	1487953.JMKF01000058_gene4978	2.107e-86	293.0	COG2307@1|root,COG2307@2|Bacteria,1G05F@1117|Cyanobacteria,1H8SU@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
TLS3_k127_5195363_0	316067.Geob_1523	3.712e-24	116.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2WKHT@28221|Deltaproteobacteria,43T2W@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM permease YjgP YjgQ family protein	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS3_k127_5198726_2	1216976.AX27061_2279	3.053e-28	115.0	COG3863@1|root,COG3863@2|Bacteria,1RBGX@1224|Proteobacteria,2VYTV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
TLS3_k127_5198726_0	944479.JQLX01000011_gene834	8.574e-88	302.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2M6ZZ@213113|Desulfurellales	28221|Deltaproteobacteria	E	Chorismate mutase type II	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
TLS3_k127_5198726_1	649747.HMPREF0083_01805	2.111e-37	147.0	COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,4HIQ0@91061|Bacilli,26SV4@186822|Paenibacillaceae	91061|Bacilli	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS3_k127_5198726_4	1121004.ATVC01000006_gene1294	1.541e-13	81.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,2KQ4N@206351|Neisseriales	206351|Neisseriales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS3_k127_5198726_3	517417.Cpar_2044	9.65e-26	109.0	COG0180@1|root,COG0180@2|Bacteria,1FE4Z@1090|Chlorobi	1090|Chlorobi	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS3_k127_5208453_0	1392502.JNIO01000008_gene1938	9.608e-53	191.0	COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,4H3V2@909932|Negativicutes	909932|Negativicutes	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
TLS3_k127_5208453_1	1150600.ADIARSV_2404	1.56e-38	150.0	COG1392@1|root,COG1392@2|Bacteria,4NI25@976|Bacteroidetes,1INNB@117747|Sphingobacteriia	976|Bacteroidetes	P	COGs COG1392 Phosphate transport regulator (distant homolog of PhoU)	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
TLS3_k127_5211293_1	742765.HMPREF9457_02809	2.776e-10	72.0	COG0027@1|root,COG0027@2|Bacteria	2|Bacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,CPSase_L_D2
TLS3_k127_5211293_0	1123248.KB893370_gene4948	8.372e-239	764.0	COG0474@1|root,COG0474@2|Bacteria,4NERM@976|Bacteroidetes,1IR88@117747|Sphingobacteriia	976|Bacteroidetes	P	TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	yoaB	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS3_k127_522097_0	1449126.JQKL01000032_gene1234	9.44e-75	267.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,26822@186813|unclassified Clostridiales	186801|Clostridia	E	Homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TLS3_k127_522097_1	1122216.AUHW01000003_gene634	2.447e-26	122.0	COG1462@1|root,COG1462@2|Bacteria,1UNVC@1239|Firmicutes,4H9IF@909932|Negativicutes	2|Bacteria	M	LPP20 lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TLS3_k127_522097_2	195253.Syn6312_2702	2.337e-08	61.0	COG1462@1|root,COG1462@2|Bacteria,1G2XT@1117|Cyanobacteria,1GYVE@1129|Synechococcus	1117|Cyanobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
TLS3_k127_5224834_1	1230460.C495_12065	9.672e-55	203.0	COG1073@1|root,arCOG01658@2157|Archaea,2XUBM@28890|Euryarchaeota,23SZT@183963|Halobacteria	183963|Halobacteria	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S15
TLS3_k127_5224834_3	1173021.ALWA01000031_gene2777	1.669e-08	66.0	COG1357@1|root,COG1357@2|Bacteria,1G3AI@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Pentapeptide,Pentapeptide_3
TLS3_k127_5224834_2	1487923.DP73_02425	2.202e-17	93.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,261QI@186807|Peptococcaceae	186801|Clostridia	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS3_k127_5224834_0	96561.Dole_2620	3.183e-59	213.0	2A8H0@1|root,30XJ2@2|Bacteria,1REE0@1224|Proteobacteria,42SSU@68525|delta/epsilon subdivisions,2WUYB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5233054_0	1379270.AUXF01000001_gene2396	9.342e-51	184.0	COG0719@1|root,COG0719@2|Bacteria,1ZSMU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS3_k127_5233531_2	1147.D082_02610	8.947e-34	140.0	COG0664@1|root,COG2200@1|root,COG0664@2|Bacteria,COG2200@2|Bacteria,1G38W@1117|Cyanobacteria,1H67A@1142|Synechocystis	1117|Cyanobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,cNMP_binding
TLS3_k127_5233531_0	760568.Desku_2297	3.183e-70	249.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,260BR@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS3_k127_5233531_1	392500.Swoo_1513	2.966e-50	190.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,2QBBH@267890|Shewanellaceae	1236|Gammaproteobacteria	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
TLS3_k127_5234289_0	1403819.BATR01000008_gene241	1.745e-166	535.0	COG3852@1|root,COG5000@1|root,COG3852@2|Bacteria,COG5000@2|Bacteria,46Z98@74201|Verrucomicrobia,2IWR1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
TLS3_k127_5234289_1	1408445.JHXP01000029_gene1819	0.0007427	42.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,1RR5C@1236|Gammaproteobacteria,1JDUF@118969|Legionellales	118969|Legionellales	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS3_k127_5241075_2	1254432.SCE1572_15525	5.937e-23	108.0	COG0265@1|root,COG0526@1|root,COG0265@2|Bacteria,COG0526@2|Bacteria,1QAS6@1224|Proteobacteria,4359M@68525|delta/epsilon subdivisions,2WZKT@28221|Deltaproteobacteria,2Z2BZ@29|Myxococcales	28221|Deltaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,PDZ_2
TLS3_k127_5241075_0	1048983.EL17_21855	1.555e-72	249.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
TLS3_k127_5241075_4	761193.Runsl_1414	2.352e-11	66.0	COG0230@1|root,COG0230@2|Bacteria,4NUTV@976|Bacteroidetes,47RUZ@768503|Cytophagia	976|Bacteroidetes	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS3_k127_5241075_5	1236501.BAJU01000006_gene1052	7.649e-07	56.0	COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2UFAB@28211|Alphaproteobacteria,2JU1B@204441|Rhodospirillales	204441|Rhodospirillales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS3_k127_5241075_1	471854.Dfer_5567	1.935e-26	113.0	COG1695@1|root,COG1695@2|Bacteria,4NQWD@976|Bacteroidetes,47Y0M@768503|Cytophagia	976|Bacteroidetes	K	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180
TLS3_k127_5241075_3	655811.HMPREF0078_1559	2.283e-21	95.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia,22HUD@1570339|Peptoniphilaceae	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS3_k127_5242584_0	517418.Ctha_0833	5.654e-14	76.0	COG0707@1|root,COG0707@2|Bacteria,1FDRW@1090|Chlorobi	1090|Chlorobi	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS3_k127_5247384_0	1293054.HSACCH_00156	2.096e-14	84.0	COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,3WB65@53433|Halanaerobiales	186801|Clostridia	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
TLS3_k127_5247384_1	1279017.AQYJ01000029_gene3328	7.233e-05	49.0	COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,1RMTE@1236|Gammaproteobacteria,464VK@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34	mnmC	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363	2.1.1.61	ko:K15461	-	-	R00601,R08702	RC00003,RC00053,RC00060,RC01483	ko00000,ko01000,ko03016	-	-	-	DAO,Methyltransf_30
TLS3_k127_5256285_1	379066.GAU_0630	1.716e-29	123.0	COG3495@1|root,COG3495@2|Bacteria,1ZUU7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF3299)	-	-	-	ko:K09950	-	-	-	-	ko00000	-	-	-	DUF3299
TLS3_k127_5256285_0	1219072.VHA01S_003_01570	6.776e-48	181.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,1S275@1236|Gammaproteobacteria,1XUZ7@135623|Vibrionales	135623|Vibrionales	V	COG1136 ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_5256285_2	1161401.ASJA01000017_gene1304	6.156e-25	107.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,2TTEF@28211|Alphaproteobacteria,43WG8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	V	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_527133_3	1423815.BACR01000045_gene2267	5.772e-06	51.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HA2A@91061|Bacilli,3F40U@33958|Lactobacillaceae	91061|Bacilli	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.8.6	ko:K00248,ko:K00252,ko:K18244	ko00071,ko00280,ko00310,ko00362,ko00380,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00310,map00362,map00380,map00650,map01100,map01110,map01120,map01130,map01200,map01212	M00032	R01175,R01178,R02487,R02488,R02661,R03172,R04751,R10074	RC00052,RC00068,RC00076,RC00120,RC00148,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_527133_0	1122176.KB903541_gene194	1.225e-82	285.0	COG0596@1|root,COG0596@2|Bacteria,4NFBJ@976|Bacteroidetes	976|Bacteroidetes	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_527133_2	1038862.KB893840_gene935	2.41e-36	151.0	COG2207@1|root,COG2207@2|Bacteria,1P4M5@1224|Proteobacteria,2TSQV@28211|Alphaproteobacteria,3JU83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_527133_4	1207063.P24_06202	0.0001516	48.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2JPME@204441|Rhodospirillales	204441|Rhodospirillales	KQ	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
TLS3_k127_527133_1	1254432.SCE1572_13460	1.783e-47	181.0	COG3687@1|root,COG3687@2|Bacteria,1R4HJ@1224|Proteobacteria,437ZS@68525|delta/epsilon subdivisions,2X9TG@28221|Deltaproteobacteria,2YV0P@29|Myxococcales	28221|Deltaproteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
TLS3_k127_5275398_0	867903.ThesuDRAFT_01182	9.496e-177	567.0	COG0843@1|root,COG0843@2|Bacteria,1TRC2@1239|Firmicutes	1239|Firmicutes	C	COG0843 Heme copper-type cytochrome quinol oxidases, subunit 1	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS3_k127_5275398_1	522306.CAP2UW1_1791	6.431e-43	166.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome c oxidase (Subunit II)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
TLS3_k127_5275398_3	522306.CAP2UW1_1792	0.0003485	46.0	2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2VYHD@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5275398_2	247490.KSU1_B0536	2.126e-16	88.0	COG3637@1|root,COG3637@2|Bacteria,2IYBM@203682|Planctomycetes	203682|Planctomycetes	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS3_k127_527632_0	758.BBIX01000008_gene1022	5.859e-198	634.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1Y7B6@135625|Pasteurellales	135625|Pasteurellales	C	dehydrogenase E1 component	sucA	GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS3_k127_5278983_0	555793.WSK_3248	8.993e-52	195.0	COG2186@1|root,COG2186@2|Bacteria,1NSY6@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5279308_0	240015.ACP_1920	2.355e-06	56.0	COG0457@1|root,COG0457@2|Bacteria,3Y3EM@57723|Acidobacteria,2JIDA@204432|Acidobacteriia	204432|Acidobacteriia	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_11,TPR_16,TPR_2,TPR_8
TLS3_k127_5281974_0	314607.KB13_1085	1.981e-180	574.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1KQGS@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
TLS3_k127_5281974_1	1313421.JHBV01000036_gene2471	2.84e-75	264.0	2E963@1|root,333ES@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
TLS3_k127_5281974_2	944480.ATUV01000001_gene1243	3.81e-70	241.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,2M6Q8@213113|Desulfurellales	28221|Deltaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
TLS3_k127_5281974_3	1122222.AXWR01000053_gene49	4.808e-11	72.0	COG3234@1|root,COG3234@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1175)	yfaT	-	-	ko:K09934	-	-	-	-	ko00000	-	-	-	DUF1175
TLS3_k127_528775_0	1382359.JIAL01000001_gene2659	4.997e-07	61.0	COG2706@1|root,COG2706@2|Bacteria,3Y76Q@57723|Acidobacteria,2JMA2@204432|Acidobacteriia	204432|Acidobacteriia	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_5293311_0	666681.M301_2309	4.995e-74	276.0	COG2203@1|root,COG3447@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KNQY@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
TLS3_k127_529742_0	391735.Veis_0110	3.314e-123	402.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2WFJM@28216|Betaproteobacteria,4AD19@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS3_k127_529742_1	1454007.JAUG01000072_gene4113	2.467e-34	136.0	COG0833@1|root,COG0833@2|Bacteria,4PN7J@976|Bacteroidetes,1IQ7E@117747|Sphingobacteriia	976|Bacteroidetes	E	Amino acid permease	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	AA_permease_2
TLS3_k127_5299914_0	857293.CAAU_0009	3.17e-70	246.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,36E6C@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS3_k127_5299914_1	887327.HMPREF0476_1428	7.006e-48	176.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,2KPUH@206351|Neisseriales	206351|Neisseriales	L	hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS3_k127_5307518_0	1192034.CAP_0838	5.089e-259	807.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJBM@28221|Deltaproteobacteria,2YTUN@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
TLS3_k127_5312580_0	1142394.PSMK_30660	1.218e-82	284.0	COG4631@1|root,COG4631@2|Bacteria,2J56Q@203682|Planctomycetes	203682|Planctomycetes	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4,1.17.3.2	ko:K00106,ko:K13482	ko00230,ko00232,ko00983,ko01100,ko01110,ko01120,ko04146,map00230,map00232,map00983,map01100,map01110,map01120,map04146	M00546	R01768,R01769,R02103,R02107,R07942,R07977,R07978,R07979,R08235	RC00143,RC02017,RC02199	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_5312580_2	1142394.PSMK_30670	5.382e-65	231.0	COG1975@1|root,COG1975@2|Bacteria,2IXRN@203682|Planctomycetes	203682|Planctomycetes	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS3_k127_5312580_3	768706.Desor_2211	9.285e-38	155.0	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,26128@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
TLS3_k127_5312580_4	1125700.HMPREF9195_01795	8.149e-33	140.0	COG1262@1|root,COG5492@1|root,COG1262@2|Bacteria,COG5492@2|Bacteria,2J6K7@203691|Spirochaetes	203691|Spirochaetes	N	hmm pf03781	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,FGE-sulfatase
TLS3_k127_5312580_1	1184267.A11Q_937	8.933e-66	231.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2MT0Z@213481|Bdellovibrionales,2WMRQ@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	peptidylprolyl isomerase, FKBP-type	-	-	5.2.1.8	ko:K01802,ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	iAF987.Gmet_2161	FKBP_C,FKBP_N
TLS3_k127_5312580_5	1489678.RDMS_04715	6.303e-16	87.0	COG1427@1|root,COG1427@2|Bacteria,1WIAQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
TLS3_k127_531455_1	1283300.ATXB01000001_gene1722	6.447e-23	112.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
TLS3_k127_531455_0	1120999.JONM01000006_gene2493	7.635e-30	129.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,2KPXX@206351|Neisseriales	206351|Neisseriales	M	Transglycosylase SLT domain protein	sltY	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
TLS3_k127_531536_0	1123070.KB899250_gene639	1.145e-09	69.0	COG2982@1|root,COG2982@2|Bacteria,46XT1@74201|Verrucomicrobia,2IWHV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_531631_1	439235.Dalk_4291	1.195e-31	126.0	COG4680@1|root,COG4680@2|Bacteria,1N036@1224|Proteobacteria,42VA0@68525|delta/epsilon subdivisions,2WS1B@28221|Deltaproteobacteria,2MM7J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	HigB_toxin, RelE-like toxic component of a toxin-antitoxin system	-	-	-	ko:K19166	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HigB_toxin
TLS3_k127_531631_0	945713.IALB_0331	2.257e-34	135.0	COG5499@1|root,COG5499@2|Bacteria	2|Bacteria	K	transcription regulator containing HTH domain	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,Peptidase_M78
TLS3_k127_5330334_0	1353537.TP2_08400	2.374e-26	114.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2XMWN@285107|Thioclava	28211|Alphaproteobacteria	H	ThiF family	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS3_k127_5330334_1	105422.BBPM01000084_gene7300	5.312e-19	95.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,2NG8W@228398|Streptacidiphilus	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS3_k127_5331615_1	41431.PCC8801_3110	4.355e-10	67.0	2FARY@1|root,342ZC@2|Bacteria,1GEIJ@1117|Cyanobacteria,3KIG2@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5331615_0	1123253.AUBD01000011_gene2020	3.847e-76	256.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1X67E@135614|Xanthomonadales	135614|Xanthomonadales	E	Glyoxalase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS3_k127_5333947_0	1121472.AQWN01000005_gene2382	2.14e-26	125.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,260BC@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS_4
TLS3_k127_5334869_0	1123276.KB893262_gene4085	4.441e-127	412.0	COG0798@1|root,COG0798@2|Bacteria,4NFG7@976|Bacteroidetes,47M0B@768503|Cytophagia	976|Bacteroidetes	P	PFAM Sodium Bile acid symporter family	acr3	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS3_k127_5334869_1	929562.Emtol_1346	1.449e-67	233.0	COG0394@1|root,COG0394@2|Bacteria,4NNN6@976|Bacteroidetes,47PU6@768503|Cytophagia	976|Bacteroidetes	T	Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS3_k127_5340675_0	1249627.D779_0959	9.088e-94	318.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1WWYH@135613|Chromatiales	135613|Chromatiales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TLS3_k127_5340675_1	572477.Alvin_0544	9.292e-42	164.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1WWR8@135613|Chromatiales	135613|Chromatiales	S	PFAM Bacterial domain of	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
TLS3_k127_5346698_0	335543.Sfum_2802	3.733e-70	250.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MQZ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
TLS3_k127_5352969_0	1111454.HMPREF1250_1866	5.704e-52	198.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4H1XT@909932|Negativicutes	909932|Negativicutes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
TLS3_k127_5352969_1	1120970.AUBZ01000026_gene2147	1.215e-14	76.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,4648R@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS3_k127_5357179_0	1287116.X734_21500	6.239e-26	120.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,43IJH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS3_k127_5369152_1	1463934.JOCF01000061_gene3270	3.03e-64	237.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 1 family	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS3_k127_5369152_0	604331.AUHY01000020_gene1922	4.549e-94	318.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	amaB	-	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iPC815.YPO3249	M20_dimer,OHCU_decarbox,Peptidase_M20,Peptidase_M28
TLS3_k127_5383239_0	289377.HL41_02985	2.226e-106	372.0	COG0643@1|root,COG0643@2|Bacteria,2GH2Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
TLS3_k127_5383239_2	1125863.JAFN01000001_gene1189	9.851e-19	94.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SW0@68525|delta/epsilon subdivisions,2WPFF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TLS3_k127_5383239_1	765913.ThidrDRAFT_0518	2.625e-53	203.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WXMA@135613|Chromatiales	135613|Chromatiales	T	Chemotaxis sensory transducer	-	-	-	ko:K03776	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,PAS_3
TLS3_k127_538707_3	1463861.JNXE01000024_gene7132	5.675e-22	103.0	COG2353@1|root,COG2353@2|Bacteria,2IFEK@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS3_k127_538707_2	1499689.CCNN01000007_gene1109	2.527e-27	119.0	COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia,36FUY@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS3_k127_538707_1	404589.Anae109_4368	1.045e-30	131.0	COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria,42X79@68525|delta/epsilon subdivisions,2WXA0@28221|Deltaproteobacteria,2YVD9@29|Myxococcales	28221|Deltaproteobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS3_k127_5387322_0	1480694.DC28_10570	1.774e-37	160.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
TLS3_k127_5388531_1	765420.OSCT_2410	4.007e-17	83.0	COG0614@1|root,COG0614@2|Bacteria,2G9KR@200795|Chloroflexi,377DT@32061|Chloroflexia	32061|Chloroflexia	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TLS3_k127_5388531_0	1480694.DC28_02580	4.667e-56	206.0	COG1344@1|root,COG1344@2|Bacteria,2J6BJ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein 3	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
TLS3_k127_5392987_0	665571.STHERM_c11070	2.508e-44	176.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
TLS3_k127_5405377_1	246194.CHY_2348	4.897e-192	615.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS3_k127_5405377_5	627192.SLG_03890	1.957e-06	55.0	COG5469@1|root,COG5469@2|Bacteria,1NH70@1224|Proteobacteria,2UM6U@28211|Alphaproteobacteria,2KCAK@204457|Sphingomonadales	204457|Sphingomonadales	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5405377_2	631362.Thi970DRAFT_00187	3.781e-47	172.0	COG3577@1|root,COG3577@2|Bacteria,1MYMV@1224|Proteobacteria,1S8C8@1236|Gammaproteobacteria,1WYQ4@135613|Chromatiales	135613|Chromatiales	S	Clan AA aspartic protease, AF_0612 family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5405377_4	203122.Sde_3782	2.22e-15	81.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	5.3.3.19	ko:K19547	ko01130,map01130	M00787	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,HATPase_c,His_kinase,PocR
TLS3_k127_5405377_3	641524.ADICYQ_5091	4.886e-18	94.0	2E39A@1|root,32Y8X@2|Bacteria,4NWB4@976|Bacteroidetes,47SFE@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
TLS3_k127_5405377_0	370438.PTH_2220	1.469e-298	954.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS3_k127_5405377_6	370438.PTH_2386	0.0002404	53.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,26097@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,AAA_16,GAF,GAF_2,HATPase_c,HisKA,Hpt,Pkinase,Response_reg
TLS3_k127_5407470_2	742767.HMPREF9456_02022	9.435e-23	99.0	COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,2FM01@200643|Bacteroidia,22VWZ@171551|Porphyromonadaceae	976|Bacteroidetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
TLS3_k127_5407470_3	1183438.GKIL_3917	3.354e-06	55.0	COG0858@1|root,COG0858@2|Bacteria,1G6JJ@1117|Cyanobacteria	1117|Cyanobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS3_k127_5407470_1	483219.LILAB_16725	2.314e-49	188.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,43BK7@68525|delta/epsilon subdivisions,2X5W4@28221|Deltaproteobacteria,2Z37Z@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_5407470_0	1500306.JQLA01000004_gene5563	2.523e-74	259.0	COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,4BAA0@82115|Rhizobiaceae	28211|Alphaproteobacteria	CT	Adenylyl- / guanylyl cyclase, catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Guanylate_cyc
TLS3_k127_54151_0	1117319.PSPO_01106	2.041e-37	155.0	COG1345@1|root,COG1345@2|Bacteria	2|Bacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	-	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Big_3_5,Flg_bbr_C,FliD_C,LTD,Peptidase_S8,SWM_repeat,TMP_2,VCBS
TLS3_k127_54151_1	768710.DesyoDRAFT_4321	1.704e-35	152.0	COG1368@1|root,COG1368@2|Bacteria,1TQYQ@1239|Firmicutes,25CNS@186801|Clostridia,264HF@186807|Peptococcaceae	186801|Clostridia	M	Phosphoglycerol transferase family protein, alkaline phosphatase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
TLS3_k127_541605_1	1238182.C882_2514	2.773e-56	214.0	COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,2JQ73@204441|Rhodospirillales	204441|Rhodospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_541605_3	313606.M23134_01153	9.145e-15	76.0	2EMN4@1|root,33FAG@2|Bacteria,4NYZA@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_541605_5	1485545.JQLW01000011_gene1392	0.0004918	50.0	COG0666@1|root,COG0666@2|Bacteria,1NH1G@1224|Proteobacteria	1224|Proteobacteria	S	FOG Ankyrin repeat	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4,Ank_5
TLS3_k127_541605_2	1499967.BAYZ01000161_gene390	2.271e-33	139.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2NNXD@2323|unclassified Bacteria	2|Bacteria	LV	Eco57I restriction-modification methylase	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,HSDR_N,N6_Mtase,TaqI_C
TLS3_k127_541605_0	76114.ebA2304	8.925e-87	295.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHUJ@28216|Betaproteobacteria,2KWM7@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS3_k127_5416996_0	880073.Calab_3776	1.554e-99	335.0	COG0621@1|root,COG0621@2|Bacteria,2NNUN@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS3_k127_5419204_0	1337936.IJ00_14985	8.148e-42	161.0	COG0345@1|root,COG0345@2|Bacteria,1FZW1@1117|Cyanobacteria,1HIZP@1161|Nostocales	1117|Cyanobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS3_k127_5419204_1	1121353.H924_06125	3.513e-16	90.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,22K0Y@1653|Corynebacteriaceae	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
TLS3_k127_5421181_0	246197.MXAN_6525	1.572e-20	102.0	297YV@1|root,2ZV50@2|Bacteria,1N204@1224|Proteobacteria,43116@68525|delta/epsilon subdivisions,2WZCN@28221|Deltaproteobacteria,2Z1US@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1826)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1826
TLS3_k127_5422313_0	479433.Caci_5825	1.347e-148	483.0	COG1032@1|root,COG1032@2|Bacteria,2GZU1@201174|Actinobacteria	201174|Actinobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5425014_3	1184267.A11Q_1509	7.444e-28	119.0	COG2010@1|root,COG2010@2|Bacteria,1RDVX@1224|Proteobacteria,42WYA@68525|delta/epsilon subdivisions,2MTWM@213481|Bdellovibrionales,2WT1Y@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
TLS3_k127_5425014_4	1124780.ANNU01000003_gene1433	5.391e-16	85.0	COG2010@1|root,COG2010@2|Bacteria,4NKQI@976|Bacteroidetes,47PEX@768503|Cytophagia	976|Bacteroidetes	C	PFAM Cytochrome C	actE	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
TLS3_k127_5425014_0	1297742.A176_05066	3.703e-65	238.0	COG4531@1|root,COG4531@2|Bacteria,1REHQ@1224|Proteobacteria,42TZ1@68525|delta/epsilon subdivisions,2WQ6N@28221|Deltaproteobacteria,2YY91@29|Myxococcales	28221|Deltaproteobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5425014_1	1120973.AQXL01000121_gene82	5.596e-47	176.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4HC7B@91061|Bacilli,278YZ@186823|Alicyclobacillaceae	91061|Bacilli	H	Lumazine binding domain	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08950,iYO844.BSU23270	Lum_binding
TLS3_k127_5425014_2	1123400.KB904747_gene558	1.862e-41	162.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales	72273|Thiotrichales	LU	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS3_k127_5425014_5	1385935.N836_26825	4.165e-05	46.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G1PT@1117|Cyanobacteria,1H7NV@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,PAS,PAS_8
TLS3_k127_5435347_0	1123388.AQWU01000061_gene937	0.0001563	52.0	COG1214@1|root,COG1214@2|Bacteria,1WJSS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	PFAM Peptidase M22, glycoprotease	-	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS3_k127_5438432_0	56107.Cylst_1828	1.559e-66	247.0	COG0517@1|root,COG0784@1|root,COG2202@1|root,COG3290@1|root,COG4191@1|root,COG5000@1|root,COG0517@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1G1PE@1117|Cyanobacteria,1HM9U@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
TLS3_k127_5439861_0	889378.Spiaf_2483	2.453e-83	287.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS3_k127_5440044_0	1245469.S58_28330	7.616e-35	141.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2U117@28211|Alphaproteobacteria,3JUNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nitrilase cyanide hydratase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_5440044_1	316067.Geob_0679	1.153e-17	88.0	COG1186@1|root,COG1186@2|Bacteria,1NBAD@1224|Proteobacteria,42UTT@68525|delta/epsilon subdivisions,2WQZK@28221|Deltaproteobacteria,43VGU@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
TLS3_k127_5440044_2	760192.Halhy_1255	3.381e-10	68.0	COG3103@1|root,COG4991@2|Bacteria,4NXC6@976|Bacteroidetes	976|Bacteroidetes	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS3_k127_5444222_0	1410618.JNKI01000002_gene933	1.949e-22	107.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4H201@909932|Negativicutes	909932|Negativicutes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS3_k127_5444222_1	446470.Snas_6425	2.82e-21	98.0	2E37T@1|root,32Y7G@2|Bacteria,2GQH5@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
TLS3_k127_5444222_2	306281.AJLK01000156_gene4638	1.749e-17	86.0	COG4640@1|root,COG4640@2|Bacteria,1G9F8@1117|Cyanobacteria	1117|Cyanobacteria	S	Interferon-induced transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CD225
TLS3_k127_5445015_0	504728.K649_05055	1.416e-124	409.0	COG2723@1|root,COG2723@2|Bacteria,1WIBW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glycosyl hydrolase family 1	-	-	3.2.1.21,3.2.1.86	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	-	R00026,R00839,R02558,R02887,R02985,R03527,R04949,R04998,R05133,R05134,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GT1	-	Glyco_hydro_1
TLS3_k127_544595_0	1296416.JACB01000057_gene1483	4.056e-08	64.0	COG0793@1|root,COG0793@2|Bacteria,4NJAA@976|Bacteroidetes,1I1MJ@117743|Flavobacteriia,2YKBQ@290174|Aquimarina	976|Bacteroidetes	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
TLS3_k127_5447084_1	1237149.C900_05331	7.735e-31	130.0	COG1409@1|root,COG4775@1|root,COG1409@2|Bacteria,COG4775@2|Bacteria,4NF9N@976|Bacteroidetes,47JAP@768503|Cytophagia	976|Bacteroidetes	M	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,Metallophos,ShlB
TLS3_k127_5447084_2	1123367.C666_07745	3.829e-19	102.0	COG3083@1|root,COG3083@2|Bacteria,1MX6X@1224|Proteobacteria,2VJH1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF3413)	-	-	-	ko:K07014	-	-	-	-	ko00000	-	-	-	DUF3413,Sulfatase
TLS3_k127_5447084_0	204669.Acid345_4657	1.287e-34	150.0	COG2208@1|root,COG2208@2|Bacteria,3Y6AE@57723|Acidobacteria,2JKYD@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
TLS3_k127_544870_1	290397.Adeh_0872	1.983e-51	188.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1RE8Z@1224|Proteobacteria,42VZV@68525|delta/epsilon subdivisions,2WRHV@28221|Deltaproteobacteria,2YWGA@29|Myxococcales	28221|Deltaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
TLS3_k127_544870_0	264198.Reut_B4743	3.619e-146	469.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,1K1F3@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_5449765_2	7425.NV22850-PA	3.23e-11	74.0	COG0666@1|root,KOG4177@2759|Eukaryota,3AN2N@33154|Opisthokonta	33154|Opisthokonta	M	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2
TLS3_k127_5449765_0	345219.Bcoa_0856	1.173e-12	82.0	COG2911@1|root,COG4412@1|root,COG2911@2|Bacteria,COG4412@2|Bacteria,1UHPT@1239|Firmicutes,4IS5N@91061|Bacilli	91061|Bacilli	M	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Gram_pos_anchor,YSIRK_signal
TLS3_k127_5449765_1	1303518.CCALI_00291	2.036e-12	81.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	NHL
TLS3_k127_5449929_0	1123499.KB908034_gene329	3.934e-32	134.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KQCT@206351|Neisseriales	206351|Neisseriales	T	Histidine kinase-like ATPases	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
TLS3_k127_5449929_1	1485543.JMME01000011_gene1531	0.0004424	53.0	COG2208@1|root,COG5000@1|root,COG2208@2|Bacteria,COG5000@2|Bacteria,1TQY5@1239|Firmicutes,4H4HJ@909932|Negativicutes	909932|Negativicutes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
TLS3_k127_5454446_1	5722.XP_001326357.1	3.186e-07	61.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
TLS3_k127_5454446_0	103690.17130911	2.45e-19	91.0	COG4636@1|root,COG4636@2|Bacteria,1G4JH@1117|Cyanobacteria,1HITX@1161|Nostocales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_5455938_0	1122201.AUAZ01000023_gene3032	1.74e-206	652.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,464PE@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.71	ko:K00128,ko:K06447	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05049,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_5455938_2	716928.AJQT01000043_gene3204	2.721e-19	91.0	2DNXR@1|root,32ZPP@2|Bacteria,1N6PT@1224|Proteobacteria,2UFF3@28211|Alphaproteobacteria,4BFE6@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
TLS3_k127_5455938_1	614083.AWQR01000039_gene1498	7.727e-20	91.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,2VTBF@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_5461995_1	1047013.AQSP01000133_gene2131	5.054e-13	79.0	COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TLS3_k127_5461995_0	416591.Tlet_0835	2.746e-29	121.0	COG1832@1|root,COG1832@2|Bacteria,2GDCX@200918|Thermotogae	200918|Thermotogae	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS3_k127_5461995_3	1123057.P872_07655	0.0004279	51.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494,He_PIG
TLS3_k127_5461995_2	589865.DaAHT2_0387	1.186e-05	58.0	COG2706@1|root,COG5276@1|root,COG5492@1|root,COG2706@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1R8Z4@1224|Proteobacteria,42U3Q@68525|delta/epsilon subdivisions,2WQZX@28221|Deltaproteobacteria,2MKPP@213118|Desulfobacterales	28221|Deltaproteobacteria	N	PFAM Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF1566,Peptidase_C13
TLS3_k127_5470939_0	383372.Rcas_3987	9.172e-06	57.0	COG0457@1|root,COG0457@2|Bacteria,2G73P@200795|Chloroflexi,374UJ@32061|Chloroflexia	32061|Chloroflexia	S	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_6,TPR_7,TPR_8
TLS3_k127_547640_1	643867.Ftrac_2742	2.334e-25	116.0	COG4548@1|root,COG4548@2|Bacteria,4NIHR@976|Bacteroidetes,47U2R@768503|Cytophagia	976|Bacteroidetes	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_CoxE
TLS3_k127_547640_0	1107311.Q767_05590	1.583e-50	185.0	COG4548@1|root,COG4548@2|Bacteria,4NIHR@976|Bacteroidetes,1HWKM@117743|Flavobacteriia,2NUNK@237|Flavobacterium	976|Bacteroidetes	P	NorD protein	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_CoxE
TLS3_k127_5480405_1	754477.Q7C_1159	1.689e-16	85.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,460G8@72273|Thiotrichales	72273|Thiotrichales	J	class II (D, K and N)	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
TLS3_k127_5480405_0	1356852.N008_12705	4.936e-35	143.0	COG3531@1|root,COG3531@2|Bacteria,4NQKI@976|Bacteroidetes,47QFT@768503|Cytophagia	976|Bacteroidetes	O	DSBA-like thioredoxin domain	dsbC	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	DSBA,Thioredoxin_5
TLS3_k127_5488418_0	665571.STHERM_c16380	4.552e-252	798.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS3_k127_5494827_0	926562.Oweho_1068	2.514e-08	65.0	2EGT8@1|root,33AJC@2|Bacteria,4NY9U@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5494827_1	1207076.ALAT01000203_gene1822	4.266e-08	58.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1Z2FT@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS3_k127_5505698_1	1121406.JAEX01000014_gene2329	1.022e-59	216.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2M8FJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS3_k127_5505698_0	1192759.AKIB01000039_gene1470	3.219e-65	228.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2U70I@28211|Alphaproteobacteria,2K3XA@204457|Sphingomonadales	204457|Sphingomonadales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS3_k127_551619_1	1307761.L21SP2_2314	4.29e-41	157.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS3_k127_551619_0	264462.Bd3206	3.019e-41	162.0	COG0400@1|root,COG0400@2|Bacteria,1N0UF@1224|Proteobacteria,42TUA@68525|delta/epsilon subdivisions,2MT5K@213481|Bdellovibrionales,2WQDY@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Serine hydrolase (FSH1)	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS3_k127_551619_2	1033732.CAHI01000030_gene915	5.622e-08	55.0	COG0029@1|root,COG0029@2|Bacteria,4NGUE@976|Bacteroidetes,2FNMT@200643|Bacteroidia,22V48@171550|Rikenellaceae	976|Bacteroidetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS3_k127_5522984_0	1121877.JQKF01000019_gene2595	7.88e-29	122.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_5522984_1	96561.Dole_1868	5.966e-24	117.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_5522984_3	489825.LYNGBM3L_40940	2.674e-06	58.0	2DMX9@1|root,32U7V@2|Bacteria,1G9W1@1117|Cyanobacteria,1HDPY@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5522984_2	1235800.C819_03026	5.176e-11	72.0	COG1442@1|root,COG1442@2|Bacteria,1VGDI@1239|Firmicutes,24RHD@186801|Clostridia,27PNJ@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF4422,Glyco_transf_8
TLS3_k127_5527118_0	1121104.AQXH01000001_gene1585	3.705e-78	274.0	COG0454@1|root,COG0456@2|Bacteria,4NFWE@976|Bacteroidetes,1IPDZ@117747|Sphingobacteriia	976|Bacteroidetes	K	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_5527118_1	1189612.A33Q_2632	1.447e-23	113.0	COG4775@1|root,COG4775@2|Bacteria,4NMIQ@976|Bacteroidetes,47PGI@768503|Cytophagia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
TLS3_k127_5528204_0	114615.BRADO6329	4.185e-105	355.0	COG2355@1|root,COG3568@1|root,COG2355@2|Bacteria,COG3568@2|Bacteria,1R8HG@1224|Proteobacteria,2UNI6@28211|Alphaproteobacteria,3K34W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Ricin-type beta-trefoil	-	-	-	-	-	-	-	-	-	-	-	-	Jacalin,Ricin_B_lectin
TLS3_k127_5537361_0	1282361.ABAC402_13860	2.404e-43	164.0	COG5018@1|root,COG5018@2|Bacteria,1RE77@1224|Proteobacteria,2UJI9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
TLS3_k127_5539505_0	243231.GSU1822	3.443e-62	230.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,43TPJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TLS3_k127_5542115_0	1038858.AXBA01000009_gene568	5.469e-07	62.0	COG1807@1|root,COG1807@2|Bacteria,1NAG4@1224|Proteobacteria,2U4AD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Alg9-like mannosyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22
TLS3_k127_5545656_2	105559.Nwat_2072	1.012e-07	56.0	COG2208@1|root,COG2208@2|Bacteria,1NZTV@1224|Proteobacteria	1224|Proteobacteria	KT	PFAM Stage II sporulation E family protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS3_k127_5545656_1	765420.OSCT_0172	2.052e-36	143.0	COG0102@1|root,COG0102@2|Bacteria,2G6M4@200795|Chloroflexi,3775K@32061|Chloroflexia	32061|Chloroflexia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS3_k127_5545656_0	632335.Calkr_0494	5.111e-37	145.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,42G8M@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS3_k127_5545656_3	1196029.ALIM01000032_gene1232	2.599e-05	56.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4IQKZ@91061|Bacilli,1ZRKZ@1386|Bacillus	91061|Bacilli	O	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N_3
TLS3_k127_5545656_4	765913.ThidrDRAFT_1801	7.671e-05	46.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1RSMI@1236|Gammaproteobacteria,1WW4D@135613|Chromatiales	135613|Chromatiales	NT	PFAM CheW-like	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
TLS3_k127_5547411_0	765420.OSCT_3124	3.579e-45	177.0	COG1207@1|root,COG1207@2|Bacteria,2GBS0@200795|Chloroflexi,376CX@32061|Chloroflexia	32061|Chloroflexia	M	Sugar nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_4
TLS3_k127_555304_1	1121127.JAFA01000015_gene6358	1.614e-10	70.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VR04@28216|Betaproteobacteria,1KH4M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
TLS3_k127_555304_0	237368.SCABRO_01544	5.359e-18	98.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
TLS3_k127_5559528_0	1262449.CP6013_0473	4.603e-46	178.0	COG0491@1|root,COG0491@2|Bacteria,1W0NR@1239|Firmicutes,24EYN@186801|Clostridia,36H0K@31979|Clostridiaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_5559528_1	1280390.CBQR020000004_gene85	1.808e-34	139.0	COG1309@1|root,COG1309@2|Bacteria,1V1DM@1239|Firmicutes,4HG0Y@91061|Bacilli,26WH9@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	yobS	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS3_k127_5566717_0	1173027.Mic7113_0229	1.959e-31	125.0	COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1HCCX@1150|Oscillatoriales	1117|Cyanobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS3_k127_5571884_0	1313421.JHBV01000042_gene3327	6.131e-76	264.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS3_k127_5571884_2	555088.DealDRAFT_0189	1.497e-22	106.0	COG0454@1|root,COG0456@2|Bacteria,1UQW2@1239|Firmicutes,24V33@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_5571884_3	749222.Nitsa_0594	0.0003875	52.0	COG2143@1|root,COG2143@2|Bacteria,1R0ZR@1224|Proteobacteria,43D49@68525|delta/epsilon subdivisions,2YTGG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
TLS3_k127_5571884_1	1042376.AFPK01000036_gene1851	2.892e-62	219.0	COG0685@1|root,COG0685@2|Bacteria,4NJPU@976|Bacteroidetes	976|Bacteroidetes	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
TLS3_k127_5572699_1	945713.IALB_2677	3.354e-32	131.0	2D6MI@1|root,32TMJ@2|Bacteria	2|Bacteria	S	PAP2 superfamily C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_C
TLS3_k127_5572699_2	509635.N824_12855	0.0007577	52.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,4NIEU@976|Bacteroidetes,1IUS1@117747|Sphingobacteriia	976|Bacteroidetes	NU	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
TLS3_k127_5572699_0	246194.CHY_2223	3.537e-150	494.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
TLS3_k127_5577430_1	859657.RPSI07_1361	3.212e-26	109.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,1K8J9@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS3_k127_5577430_0	316067.Geob_2697	4.502e-123	409.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43TFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS3_k127_5586600_0	665571.STHERM_c01660	1.907e-15	84.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_5587609_1	1449351.RISW2_09605	2.118e-12	71.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,4KN95@93682|Roseivivax	28211|Alphaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS3_k127_5587609_0	446471.Xcel_1073	1.182e-21	103.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,4F493@85017|Promicromonosporaceae	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
TLS3_k127_5587609_3	1121938.AUDY01000002_gene405	0.0009359	48.0	COG2172@1|root,COG2172@2|Bacteria,1V1IA@1239|Firmicutes,4HFPF@91061|Bacilli,3NEGA@45667|Halobacillus	91061|Bacilli	T	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B)	rsbW	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
TLS3_k127_5587609_2	1405.DJ92_2695	4.918e-11	65.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,4HAKH@91061|Bacilli,1ZAWK@1386|Bacillus	91061|Bacilli	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:2001065	6.1.1.24	ko:K09698	ko00970,ko01100,map00970,map01100	M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSB619.SA_RS02860	tRNA-synt_1c
TLS3_k127_5591356_0	1158606.I579_02322	1.399e-101	340.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,4AZU9@81852|Enterococcaceae	91061|Bacilli	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
TLS3_k127_5597875_1	1122223.KB890698_gene902	7.264e-87	293.0	COG0624@1|root,COG0624@2|Bacteria,1WIRV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	3.5.1.116	ko:K18151	ko00230,ko01100,ko01120,map00230,map01100,map01120	-	R00469	RC00153,RC02798,RC02805	ko00000,ko00001,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_5597875_2	1121899.Q764_03785	3.306e-20	102.0	COG4319@1|root,COG4319@2|Bacteria,4NPHQ@976|Bacteroidetes,1IN3T@117743|Flavobacteriia,2NX8T@237|Flavobacterium	976|Bacteroidetes	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5597875_0	1537715.JQFJ01000002_gene793	3.296e-166	531.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,2TV1G@28211|Alphaproteobacteria,2K2KQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
TLS3_k127_5597875_3	1250006.JHZZ01000001_gene2157	1.722e-10	64.0	COG0739@1|root,COG0739@2|Bacteria,4NJUQ@976|Bacteroidetes,1IETI@117743|Flavobacteriia,3VX69@52959|Polaribacter	976|Bacteroidetes	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,UT
TLS3_k127_5600229_1	1121930.AQXG01000002_gene2268	4.426e-43	163.0	COG2010@1|root,COG2010@2|Bacteria,4NFMJ@976|Bacteroidetes,1IRZW@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM Cytochrome c, class I	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
TLS3_k127_5600229_2	1121373.KB903625_gene3173	0.0001228	47.0	COG2010@1|root,COG2010@2|Bacteria,4NXV9@976|Bacteroidetes	976|Bacteroidetes	C	Cbb3-type cytochrome oxidase component FixQ	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5600229_0	1121930.AQXG01000002_gene2266	0.0	1017.0	COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,1IP6D@117747|Sphingobacteriia	976|Bacteroidetes	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K15862	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1,FixO
TLS3_k127_5601585_0	937777.Deipe_0859	3.551e-166	535.0	COG4108@1|root,COG4108@2|Bacteria,1WNE7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
TLS3_k127_5601585_2	526222.Desal_2409	1.804e-10	71.0	COG3018@1|root,COG3018@2|Bacteria,1R9S8@1224|Proteobacteria,42RI7@68525|delta/epsilon subdivisions,2WP0N@28221|Deltaproteobacteria,2MC12@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
TLS3_k127_5601585_3	56110.Oscil6304_4158	1.35e-08	62.0	COG1366@1|root,COG1366@2|Bacteria,1G7ZR@1117|Cyanobacteria,1HD6H@1150|Oscillatoriales	1117|Cyanobacteria	T	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
TLS3_k127_5601585_1	404380.Gbem_3727	4.24e-24	112.0	COG1861@1|root,COG1861@2|Bacteria,1RG42@1224|Proteobacteria,42UCD@68525|delta/epsilon subdivisions,2WR2M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Cytidylyltransferase	-	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
TLS3_k127_5602259_1	1463887.KL590004_gene1974	0.0003341	44.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_5602259_0	314230.DSM3645_19088	4.512e-118	389.0	COG0004@1|root,COG0004@2|Bacteria,2IXR9@203682|Planctomycetes	203682|Planctomycetes	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS3_k127_5604680_0	1487953.JMKF01000061_gene4794	1.712e-156	506.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1G29B@1117|Cyanobacteria,1HHAE@1150|Oscillatoriales	1117|Cyanobacteria	L	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
TLS3_k127_5604680_1	626887.J057_16580	2.953e-34	135.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,467W5@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
TLS3_k127_561078_0	397290.C810_03341	6.032e-11	74.0	COG2604@1|root,COG2604@2|Bacteria,1V4NE@1239|Firmicutes,24CPP@186801|Clostridia,27QJE@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
TLS3_k127_5612624_0	290397.Adeh_0133	9.601e-36	149.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WNXT@28221|Deltaproteobacteria,2YV4W@29|Myxococcales	28221|Deltaproteobacteria	EGP	of the major facilitator superfamily	agmP	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,MFS_1_like,Sugar_tr
TLS3_k127_5612624_1	740709.A10D4_04650	1.16e-25	110.0	COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,1SCNB@1236|Gammaproteobacteria,2QGEQ@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF423)	ygdD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF423
TLS3_k127_5612624_2	1293054.HSACCH_00656	1.351e-09	63.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,3WARM@53433|Halanaerobiales	186801|Clostridia	D	TIGRFAM maf protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS3_k127_5621406_0	675806.VII_001316	3.346e-68	243.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,1RNVN@1236|Gammaproteobacteria,1XU5T@135623|Vibrionales	135623|Vibrionales	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_5621406_1	1501230.ET33_06445	2.212e-12	78.0	COG1309@1|root,COG1309@2|Bacteria,1V8XE@1239|Firmicutes,4HJUF@91061|Bacilli,26YRW@186822|Paenibacillaceae	91061|Bacilli	K	TetR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_5625354_1	159087.Daro_3751	6.433e-36	143.0	COG1656@1|root,COG1656@2|Bacteria,1QWEF@1224|Proteobacteria,2WGZK@28216|Betaproteobacteria,2KW1W@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4178
TLS3_k127_5625354_0	443143.GM18_2788	5.753e-261	810.0	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2WM7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Isocitrate dehydrogenase NADP-dependent, monomeric type	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
TLS3_k127_5628251_0	522772.Dacet_2287	6.47e-103	346.0	COG0162@1|root,COG0162@2|Bacteria,2GENZ@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS3_k127_5628251_1	748247.AZKH_p0114	6.81e-47	172.0	COG0346@1|root,COG0346@2|Bacteria,1N3A9@1224|Proteobacteria,2W2MH@28216|Betaproteobacteria,2KYUS@206389|Rhodocyclales	206389|Rhodocyclales	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_5639923_1	391615.ABSJ01000027_gene160	5.563e-37	147.0	COG0596@1|root,COG0596@2|Bacteria,1R4PH@1224|Proteobacteria,1S03W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,adh_short
TLS3_k127_5639923_2	1007105.PT7_0872	2.156e-05	51.0	2CGNP@1|root,32S4A@2|Bacteria,1N1J7@1224|Proteobacteria,2VXE5@28216|Betaproteobacteria,3T8B6@506|Alcaligenaceae	28216|Betaproteobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5639923_0	927658.AJUM01000017_gene3136	5.284e-173	555.0	COG0286@1|root,COG0286@2|Bacteria,4NH2U@976|Bacteroidetes,2FQ18@200643|Bacteroidia	976|Bacteroidetes	L	Helicase C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,Mrr_cat_2,N6_Mtase,ResIII
TLS3_k127_5640156_0	153721.MYP_3027	1.48e-266	847.0	COG1201@1|root,COG1201@2|Bacteria,4NGQ0@976|Bacteroidetes,47NAU@768503|Cytophagia	976|Bacteroidetes	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS3_k127_5643136_0	1463853.JOHW01000012_gene3306	4.507e-15	82.0	COG1100@1|root,COG1100@2|Bacteria,2IP2E@201174|Actinobacteria	201174|Actinobacteria	S	Small GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5643136_1	264730.PSPPH_0331	1.949e-08	63.0	COG0500@1|root,COG0500@2|Bacteria,1R5D7@1224|Proteobacteria,1T1HU@1236|Gammaproteobacteria,1Z4Y7@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
TLS3_k127_565716_0	268407.PWYN_16635	3.866e-172	553.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HE3C@91061|Bacilli,26Q8T@186822|Paenibacillaceae	91061|Bacilli	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
TLS3_k127_565716_1	1304275.C41B8_12694	8.801e-70	244.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2564,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390	PdxJ
TLS3_k127_565716_3	667014.Thein_0075	1.812e-14	85.0	COG4856@1|root,COG4856@2|Bacteria,2GGRH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
TLS3_k127_565716_2	1487921.DP68_04210	1.895e-15	78.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,36DSC@31979|Clostridiaceae	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
TLS3_k127_5661054_0	1230343.CANP01000044_gene3414	4.715e-11	71.0	COG2137@1|root,COG2137@2|Bacteria,1QC5G@1224|Proteobacteria,1T7UE@1236|Gammaproteobacteria,1JDUX@118969|Legionellales	118969|Legionellales	S	Modulates RecA activity	-	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
TLS3_k127_5663123_1	258052.JNYV01000001_gene168	0.0001407	48.0	COG2208@1|root,COG2208@2|Bacteria,2GJSK@201174|Actinobacteria,2M16U@2063|Kitasatospora	201174|Actinobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,PAS,PAS_3,Response_reg,SpoIIE
TLS3_k127_5663123_0	1173025.GEI7407_1016	1.424e-66	249.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_566533_1	1232437.KL661978_gene3775	1.886e-24	106.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,2MJ9N@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS3_k127_566533_0	1122236.KB905143_gene178	3.978e-102	345.0	COG3746@1|root,COG3746@2|Bacteria,1RAJS@1224|Proteobacteria,2W82Y@28216|Betaproteobacteria,2KNJJ@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
TLS3_k127_5666385_1	768670.Calni_0188	8.799e-12	69.0	COG1366@1|root,COG1366@2|Bacteria,2GG2I@200930|Deferribacteres	200930|Deferribacteres	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_5666385_0	99598.Cal7507_2450	5.196e-65	232.0	COG0395@1|root,COG0395@2|Bacteria,1G1XU@1117|Cyanobacteria,1HM9X@1161|Nostocales	1117|Cyanobacteria	G	PFAM Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
TLS3_k127_5666385_2	671143.DAMO_1988	0.0009021	50.0	COG1262@1|root,COG1262@2|Bacteria,2NR8C@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase
TLS3_k127_5680468_0	671143.DAMO_1697	2.784e-74	255.0	COG0004@1|root,COG0004@2|Bacteria,2NP8F@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS3_k127_5680468_1	497965.Cyan7822_1015	5.817e-15	88.0	COG0666@1|root,COG0666@2|Bacteria,1G0E1@1117|Cyanobacteria,3KG08@43988|Cyanothece	1117|Cyanobacteria	S	PFAM Ankyrin	ank	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
TLS3_k127_56809_0	861299.J421_4089	7.953e-30	123.0	COG1680@1|root,COG1680@2|Bacteria,1ZUDD@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_56809_2	498761.HM1_2776	0.0002148	51.0	COG5607@1|root,COG5607@2|Bacteria	2|Bacteria	F	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
TLS3_k127_56809_1	102129.Lepto7375DRAFT_2911	4.002e-23	108.0	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HAPE@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the P-Pant transferase superfamily	hetI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS3_k127_5690040_0	1120972.AUMH01000017_gene762	4.148e-47	185.0	COG2199@1|root,COG5001@1|root,COG2199@2|Bacteria,COG5001@2|Bacteria,1UQA9@1239|Firmicutes,4HBNE@91061|Bacilli	91061|Bacilli	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,PAS_9
TLS3_k127_5690040_1	1101195.Meth11DRAFT_1854	4.94e-45	166.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KMQE@206350|Nitrosomonadales	206350|Nitrosomonadales	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
TLS3_k127_570203_1	469617.FUAG_00372	4.556e-09	69.0	COG3475@1|root,COG3475@2|Bacteria,379WV@32066|Fusobacteria	32066|Fusobacteria	M	LicD family	-	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	LicD
TLS3_k127_570203_0	1206725.BAFU01000030_gene3046	6.846e-13	74.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_5705758_0	555079.Toce_0116	3.622e-234	736.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,42EYD@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS3_k127_5708180_0	1121374.KB891588_gene3307	2.33e-84	292.0	COG3239@1|root,COG3239@2|Bacteria,1MXTQ@1224|Proteobacteria,1RRM8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS3_k127_5740327_0	243231.GSU2308	1.117e-152	492.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	-	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
TLS3_k127_5740497_1	744872.Spica_0855	3.423e-24	109.0	COG5009@1|root,COG5009@2|Bacteria,2J5D4@203691|Spirochaetes	203691|Spirochaetes	M	penicillin-binding protein	pbp-3	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS3_k127_5740497_0	635013.TherJR_0068	3.61e-88	308.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,2602Z@186807|Peptococcaceae	186801|Clostridia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS3_k127_5753912_1	378806.STAUR_4283	4.328e-42	169.0	COG4395@1|root,COG4395@2|Bacteria,1NKJZ@1224|Proteobacteria,43793@68525|delta/epsilon subdivisions,2X2CB@28221|Deltaproteobacteria,2YYKJ@29|Myxococcales	28221|Deltaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
TLS3_k127_5753912_0	759914.BP951000_2277	3.092e-61	221.0	COG0767@1|root,COG0767@2|Bacteria,2J7HE@203691|Spirochaetes	203691|Spirochaetes	Q	Belongs to the MlaE permease family	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS3_k127_5761003_1	864702.OsccyDRAFT_4187	1.675e-18	93.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4
TLS3_k127_5761003_0	1170562.Cal6303_5398	9.867e-88	298.0	COG3000@1|root,COG3000@2|Bacteria,1GAN0@1117|Cyanobacteria,1HQ2V@1161|Nostocales	1117|Cyanobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_5761003_2	525257.HMPREF0204_11942	8.851e-08	56.0	COG0431@1|root,COG0431@2|Bacteria,4NQ3Y@976|Bacteroidetes,1I2TM@117743|Flavobacteriia,3ZRT3@59732|Chryseobacterium	976|Bacteroidetes	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS3_k127_5767227_0	6669.EFX87114	5.717e-39	152.0	COG3663@1|root,KOG4120@2759|Eukaryota,38C6W@33154|Opisthokonta,3BFC3@33208|Metazoa,3D1WB@33213|Bilateria,41UUU@6656|Arthropoda	33208|Metazoa	L	It is involved in the biological process described with DNA repair	TDG	GO:0000122,GO:0000166,GO:0000287,GO:0000700,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003712,GO:0003824,GO:0004844,GO:0005080,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005886,GO:0006139,GO:0006220,GO:0006244,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006298,GO:0006304,GO:0006355,GO:0006357,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008263,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0017076,GO:0018130,GO:0019104,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0030554,GO:0030983,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031402,GO:0031404,GO:0031420,GO:0031974,GO:0031981,GO:0032091,GO:0032182,GO:0032183,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035510,GO:0035511,GO:0035561,GO:0035562,GO:0035639,GO:0036094,GO:0040029,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043412,GO:0043621,GO:0043739,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044728,GO:0045008,GO:0045892,GO:0045934,GO:0045995,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051098,GO:0051100,GO:0051171,GO:0051172,GO:0051239,GO:0051252,GO:0051253,GO:0051336,GO:0051716,GO:0055086,GO:0055114,GO:0060255,GO:0065007,GO:0065009,GO:0070013,GO:0070988,GO:0070989,GO:0071704,GO:0071944,GO:0072527,GO:0072529,GO:0080090,GO:0080111,GO:0090304,GO:0097159,GO:0097367,GO:0097506,GO:0140097,GO:0140110,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1902544,GO:1902679,GO:1903506,GO:1903507,GO:2000026,GO:2000112,GO:2000113,GO:2001141	3.2.2.29	ko:K20813	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS3_k127_5767297_3	153721.MYP_1718	7.603e-54	199.0	COG0842@1|root,COG0842@2|Bacteria,4NKB0@976|Bacteroidetes	976|Bacteroidetes	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
TLS3_k127_5767297_1	1408473.JHXO01000012_gene318	7.535e-89	303.0	COG1131@1|root,COG1131@2|Bacteria,4NMN9@976|Bacteroidetes	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_5767297_2	1319815.HMPREF0202_00965	2.364e-72	256.0	COG2870@1|root,COG2870@2|Bacteria,378KV@32066|Fusobacteria	32066|Fusobacteria	M	Psort location Cytoplasmic, score	rfaE1	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS3_k127_5767297_0	696369.KI912183_gene1621	8.516e-188	604.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,260AT@186807|Peptococcaceae	186801|Clostridia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS3_k127_5767297_4	314278.NB231_03600	6.157e-08	55.0	COG3746@1|root,COG3746@2|Bacteria,1RAJS@1224|Proteobacteria,1S3ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
TLS3_k127_5792401_2	426117.M446_6800	2.601e-16	81.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria,1JUUN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS3_k127_5792401_1	1321815.HMPREF9193_01922	4.817e-20	96.0	COG0781@1|root,COG0781@2|Bacteria,2J7V3@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS3_k127_5792401_0	1125725.HMPREF1325_1719	6.099e-32	140.0	2EZ7M@1|root,33SDH@2|Bacteria,2J5HE@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5792401_3	502558.EGYY_09780	1.83e-06	58.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CUGJ@84998|Coriobacteriia	84998|Coriobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_580476_1	1123405.AUMM01000043_gene2596	1.806e-29	127.0	COG1121@1|root,COG1121@2|Bacteria,1V54Q@1239|Firmicutes,4HHTG@91061|Bacilli,26PVH@186821|Sporolactobacillaceae	91061|Bacilli	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TLS3_k127_580476_0	247490.KSU1_D0783	1.585e-58	214.0	COG0803@1|root,COG0803@2|Bacteria,2J0IP@203682|Planctomycetes	203682|Planctomycetes	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS3_k127_5810898_1	717606.PaecuDRAFT_0699	2.448e-39	161.0	COG5002@1|root,COG5002@2|Bacteria,1UZW7@1239|Firmicutes,4IQAP@91061|Bacilli,276A5@186822|Paenibacillaceae	91061|Bacilli	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
TLS3_k127_5810898_2	269799.Gmet_1230	1.825e-32	146.0	COG0591@1|root,COG2203@1|root,COG2208@1|root,COG0591@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1R7WZ@1224|Proteobacteria,42Q3R@68525|delta/epsilon subdivisions,2WM5A@28221|Deltaproteobacteria,43TB9@69541|Desulfuromonadales	28221|Deltaproteobacteria	EKT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SSF,SpoIIE
TLS3_k127_5810898_0	378806.STAUR_6357	3.508e-93	312.0	COG0464@1|root,COG0464@2|Bacteria,1RCHW@1224|Proteobacteria,42Z41@68525|delta/epsilon subdivisions,2WU9F@28221|Deltaproteobacteria,2YUT7@29|Myxococcales	28221|Deltaproteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS3_k127_5832225_0	1096930.L284_14915	2.902e-22	97.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,2TSH8@28211|Alphaproteobacteria,2K1V4@204457|Sphingomonadales	204457|Sphingomonadales	I	Inositol-3-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS3_k127_5832225_2	319225.Plut_0389	2.853e-07	62.0	COG0795@1|root,COG0795@2|Bacteria,1FDU4@1090|Chlorobi	1090|Chlorobi	S	PFAM permease YjgP YjgQ family protein	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS3_k127_5832225_1	1449353.JQMQ01000005_gene886	7.223e-12	70.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,2NHK7@228398|Streptacidiphilus	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
TLS3_k127_5857078_0	404589.Anae109_3061	6.689e-14	79.0	COG5522@1|root,COG5522@2|Bacteria,1QM2T@1224|Proteobacteria,435G9@68525|delta/epsilon subdivisions,2WZTR@28221|Deltaproteobacteria,2Z2QR@29|Myxococcales	28221|Deltaproteobacteria	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
TLS3_k127_5857078_1	1265505.ATUG01000002_gene2374	2.218e-08	63.0	COG2703@1|root,COG2703@2|Bacteria,1NF0M@1224|Proteobacteria	1224|Proteobacteria	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_5875595_0	1236902.ANAS01000004_gene3596	8.185e-05	48.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4EFSJ@85012|Streptosporangiales	201174|Actinobacteria	C	BFD-like [2Fe-2S] binding domain	-	-	-	ko:K00360	ko00910,ko01120,map00910,map01120	M00531	R00798	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2
TLS3_k127_5876942_0	485915.Dret_1708	6.194e-46	178.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MBRQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
TLS3_k127_5876942_1	573413.Spirs_3857	5.317e-13	70.0	COG1803@1|root,COG1803@2|Bacteria,2J8X0@203691|Spirochaetes	203691|Spirochaetes	G	methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
TLS3_k127_5881130_1	1120950.KB892785_gene250	3.767e-45	169.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DNGV@85009|Propionibacteriales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_5881130_0	65093.PCC7418_3578	5.847e-92	315.0	COG0505@1|root,COG0505@2|Bacteria,1G19V@1117|Cyanobacteria	1117|Cyanobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS3_k127_5883946_1	1076550.LH22_13520	3.153e-32	130.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,1RNVI@1236|Gammaproteobacteria,3VZN1@53335|Pantoea	1236|Gammaproteobacteria	F	adenosine	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_1640,iSF_1195.SF1648,iSFxv_1172.SFxv_1849,iS_1188.S1780	A_deaminase
TLS3_k127_5883946_0	215803.DB30_3447	2.473e-81	284.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS3_k127_590136_0	1123499.KB908023_gene1205	4.293e-38	148.0	COG0586@1|root,COG0586@2|Bacteria,1R6V4@1224|Proteobacteria,2VMXP@28216|Betaproteobacteria,2KQ67@206351|Neisseriales	206351|Neisseriales	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_590136_1	984262.SGRA_3634	1.529e-09	66.0	2EKBS@1|root,33E25@2|Bacteria,4NYC7@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
TLS3_k127_590136_2	1288494.EBAPG3_30620	1.146e-06	56.0	COG3767@1|root,COG3767@2|Bacteria,1Q9CK@1224|Proteobacteria,2WBTH@28216|Betaproteobacteria,373S9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
TLS3_k127_590249_0	187272.Mlg_2248	1.769e-69	247.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1WW7U@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS3_k127_590249_1	1173022.Cri9333_1493	1.126e-13	82.0	COG0859@1|root,COG0859@2|Bacteria,1G0KB@1117|Cyanobacteria,1H7HJ@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS3_k127_5906207_0	264462.Bd1798	1.607e-212	695.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2MTIN@213481|Bdellovibrionales,2WJ8D@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS3_k127_5906207_2	589873.EP13_05710	1.676e-33	137.0	COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,1S5RX@1236|Gammaproteobacteria,466U6@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS3_k127_5906207_1	555088.DealDRAFT_1878	4.433e-58	207.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS3_k127_5919810_1	243275.TDE_1505	5.512e-14	79.0	COG1585@1|root,COG1585@2|Bacteria,2J89B@203691|Spirochaetes	203691|Spirochaetes	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS3_k127_5919810_0	1236959.BAMT01000001_gene1671	1.329e-17	87.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2VMGT@28216|Betaproteobacteria,2KKT2@206350|Nitrosomonadales	206350|Nitrosomonadales	GK	PFAM ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS3_k127_5923439_0	391625.PPSIR1_12793	9.767e-32	136.0	COG1262@1|root,COG1262@2|Bacteria,1QA4V@1224|Proteobacteria,43DXT@68525|delta/epsilon subdivisions,2WZ5G@28221|Deltaproteobacteria,2Z1DE@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5923439_1	391625.PPSIR1_17345	5.964e-05	49.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
TLS3_k127_5926992_0	1120999.JONM01000006_gene2384	2.603e-140	455.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,2KPT2@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS3_k127_5936056_0	448385.sce6695	2.093e-44	172.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria	1224|Proteobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS3_k127_5937519_0	1121472.AQWN01000004_gene913	7.096e-156	509.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,260CD@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
TLS3_k127_5937519_1	1540257.JQMW01000009_gene3823	3.398e-21	97.0	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,36DUW@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS3_k127_593910_2	509191.AEDB02000094_gene4210	2.906e-20	93.0	COG5418@1|root,COG5418@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
TLS3_k127_593910_0	395019.Bmul_4350	5.227e-170	550.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,2WET5@28216|Betaproteobacteria,1KHUX@119060|Burkholderiaceae	28216|Betaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_593910_1	395019.Bmul_4351	3.605e-40	158.0	293C9@1|root,2ZQUV@2|Bacteria,1P74T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5941044_0	754027.HMPREF9554_01175	8.962e-16	86.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_5951874_0	96561.Dole_1197	2.346e-13	76.0	28MK7@1|root,2ZAWI@2|Bacteria,1R83K@1224|Proteobacteria,42MZ5@68525|delta/epsilon subdivisions,2WKYR@28221|Deltaproteobacteria,2MISC@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5951874_1	344747.PM8797T_20059	3.539e-12	71.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,Secretin,TPR_16,TPR_4,TPR_6,TPR_8
TLS3_k127_59528_2	880526.KE386488_gene1054	1.314e-90	307.0	COG1230@1|root,COG1230@2|Bacteria,4NIHB@976|Bacteroidetes,2FNQ7@200643|Bacteroidia,22VGK@171550|Rikenellaceae	976|Bacteroidetes	P	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
TLS3_k127_59528_3	247156.PNF1_1100	1.624e-62	228.0	COG0535@1|root,COG0535@2|Bacteria,2HJ7H@201174|Actinobacteria,4G5N1@85025|Nocardiaceae	201174|Actinobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_59528_1	1123276.KB893259_gene2546	6.201e-95	332.0	COG1109@1|root,COG1109@2|Bacteria,4NFU7@976|Bacteroidetes,47KI8@768503|Cytophagia	976|Bacteroidetes	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pgcA	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_59528_4	1123399.AQVE01000019_gene1635	7.349e-17	86.0	COG1487@1|root,COG1487@2|Bacteria,1RJMX@1224|Proteobacteria	1224|Proteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_59528_6	313628.LNTAR_15417	7.226e-09	61.0	2E9N9@1|root,33N8H@2|Bacteria	2|Bacteria	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS3_k127_59528_0	1499967.BAYZ01000122_gene3362	1.492e-215	684.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iYL1228.KPN_03016	HMGL-like,LeuA_dimer
TLS3_k127_59528_5	1122605.KB893644_gene1432	2.792e-10	69.0	COG0671@1|root,COG0671@2|Bacteria,4NF6Z@976|Bacteroidetes,1ITEY@117747|Sphingobacteriia	976|Bacteroidetes	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS3_k127_5964379_0	33035.JPJF01000050_gene835	1.811e-34	138.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,3XYQJ@572511|Blautia	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS3_k127_5964379_1	1122939.ATUD01000012_gene3150	0.0001952	52.0	COG2374@1|root,COG2374@2|Bacteria,2I2E0@201174|Actinobacteria,4CPCR@84995|Rubrobacteria	84995|Rubrobacteria	S	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
TLS3_k127_5965676_1	1117647.M5M_18875	3.715e-27	127.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1J6YF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
TLS3_k127_5965676_2	118173.KB235914_gene3331	9.399e-22	108.0	COG3274@1|root,COG3274@2|Bacteria	2|Bacteria	S	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_5965676_3	1123504.JQKD01000004_gene5011	7.807e-12	69.0	COG1545@1|root,COG1545@2|Bacteria,1RB09@1224|Proteobacteria,2VV15@28216|Betaproteobacteria,4AJFM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
TLS3_k127_5965676_0	1304284.L21TH_0375	5.427e-51	186.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24AD9@186801|Clostridia,36H90@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt
TLS3_k127_5971152_0	665571.STHERM_c04560	6.771e-75	262.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS3_k127_5980113_5	745411.B3C1_00435	6.957e-16	84.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,1SY8T@1236|Gammaproteobacteria,1JA5K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
TLS3_k127_5980113_3	1485545.JQLW01000005_gene1059	2.304e-32	131.0	COG4914@1|root,COG4914@2|Bacteria,1N1W1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5980113_4	1123236.KB899376_gene1063	4.509e-22	102.0	COG0526@1|root,COG0526@2|Bacteria,1NEB6@1224|Proteobacteria,1RWWT@1236|Gammaproteobacteria,468N9@72275|Alteromonadaceae	1236|Gammaproteobacteria	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin
TLS3_k127_5980113_2	330214.NIDE1073	1.758e-46	169.0	COG3813@1|root,COG3813@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	MA20_39405	-	-	ko:K09984	-	-	-	-	ko00000	-	-	-	DUF1272
TLS3_k127_5980113_6	318161.Sden_2083	1.764e-07	57.0	COG3258@1|root,COG3258@2|Bacteria,1R95B@1224|Proteobacteria,1RYPN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5980113_1	251229.Chro_5415	2.077e-55	202.0	28I0C@1|root,2Z856@2|Bacteria,1GM76@1117|Cyanobacteria,3VN5T@52604|Pleurocapsales	1117|Cyanobacteria	J	PFAM Restriction endonuclease, type II, SinI	-	-	-	-	-	-	-	-	-	-	-	-	RE_SinI
TLS3_k127_5980113_0	1288963.ADIS_4444	2.966e-139	449.0	COG0270@1|root,COG0270@2|Bacteria,4NJPP@976|Bacteroidetes,47JRQ@768503|Cytophagia	976|Bacteroidetes	H	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
TLS3_k127_5985332_1	886293.Sinac_0087	3.224e-44	168.0	COG0534@1|root,COG0534@2|Bacteria,2IX5Q@203682|Planctomycetes	203682|Planctomycetes	V	COG0534 Na -driven multidrug efflux pump	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_5985332_0	316067.Geob_3253	3.351e-60	219.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS3_k127_5986132_0	717785.HYPMC_2300	8.227e-07	55.0	COG1974@1|root,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	HTH_3,Peptidase_S24
TLS3_k127_6000814_0	344747.PM8797T_24291	1.712e-78	275.0	COG0436@1|root,COG0436@2|Bacteria,2IX5E@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_6000980_1	1430440.MGMSRv2_3928	3.033e-05	53.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2UAKC@28211|Alphaproteobacteria,2JSGU@204441|Rhodospirillales	204441|Rhodospirillales	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS3_k127_6000980_0	635013.TherJR_2783	2.267e-08	61.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,261EA@186807|Peptococcaceae	186801|Clostridia	GM	epimerase dehydratase	-	-	4.2.1.45,4.2.1.46	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R02426,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS3_k127_600223_1	641524.ADICYQ_4891	1.267e-06	53.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
TLS3_k127_600223_0	1250005.PHEL85_0025	9.89e-28	118.0	COG1678@1|root,COG1678@2|Bacteria,4NFQA@976|Bacteroidetes,1HXJN@117743|Flavobacteriia,3VW4W@52959|Polaribacter	976|Bacteroidetes	K	Uncharacterized ACR, COG1678	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
TLS3_k127_6008851_0	326427.Cagg_1836	1.478e-152	494.0	COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi,375PP@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_6008851_1	314230.DSM3645_27061	3.861e-99	337.0	COG0626@1|root,COG0626@2|Bacteria,2IYGK@203682|Planctomycetes	203682|Planctomycetes	E	Cys Met metabolism	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_6016356_1	485915.Dret_1086	5.57e-84	284.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2WJ24@28221|Deltaproteobacteria,2M83H@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
TLS3_k127_6016356_0	1134474.O59_000900	0.0	1134.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1FGY6@10|Cellvibrio	1236|Gammaproteobacteria	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS3_k127_6016356_3	391625.PPSIR1_18852	2.375e-35	144.0	COG0300@1|root,COG0300@2|Bacteria,1NUXK@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_6016356_2	478741.JAFS01000001_gene1388	1.126e-37	148.0	COG0508@1|root,COG0508@2|Bacteria,46SHZ@74201|Verrucomicrobia,37G3Q@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_6017149_1	869213.JCM21142_321	2.246e-16	82.0	COG2836@1|root,COG2836@2|Bacteria,4NF84@976|Bacteroidetes,47QDS@768503|Cytophagia	976|Bacteroidetes	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
TLS3_k127_6017149_2	1453498.LG45_09665	3.357e-10	66.0	COG5456@1|root,COG5456@2|Bacteria,4NUZC@976|Bacteroidetes,1I2TV@117743|Flavobacteriia,2NW27@237|Flavobacterium	976|Bacteroidetes	P	cytochrome cbb3 oxidase maturation protein CcoH	ccoH	-	-	-	-	-	-	-	-	-	-	-	FixH
TLS3_k127_6017149_0	945713.IALB_0724	2.316e-20	94.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ccoG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
TLS3_k127_6022145_0	1184267.A11Q_284	3.646e-26	117.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2MSP7@213481|Bdellovibrionales,2WJPC@28221|Deltaproteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8,TIG
TLS3_k127_6022145_1	889378.Spiaf_0105	6.779e-10	64.0	2DGCA@1|root,2ZVDU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6033751_1	553217.ENHAE0001_0363	1.656e-25	109.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,3NK4B@468|Moraxellaceae	1236|Gammaproteobacteria	H	coproporphyrinogen III oxidase	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.98.3	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R06895	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403	HemN_C,Radical_SAM
TLS3_k127_6033751_0	563192.HMPREF0179_00327	5.558e-76	267.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MG50@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
TLS3_k127_604611_1	645465.ACUR01000468_gene484	0.0008813	49.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHH,Endonuclea_NS_2,RHS,RHS_repeat,Tox-HNH-EHHH
TLS3_k127_604611_0	1484460.JSWG01000012_gene1445	1.003e-09	63.0	COG1663@1|root,COG1663@2|Bacteria,4NE2I@976|Bacteroidetes,1HWU8@117743|Flavobacteriia	976|Bacteroidetes	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
TLS3_k127_6054696_0	383372.Rcas_1867	4.027e-184	588.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi,377E8@32061|Chloroflexia	32061|Chloroflexia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS3_k127_6056756_0	1123376.AUIU01000002_gene1673	8.32e-44	164.0	COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae	40117|Nitrospirae	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS3_k127_6056756_1	1265502.KB905947_gene1071	3.104e-27	114.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,2VRC4@28216|Betaproteobacteria,4AE4Z@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
TLS3_k127_6062242_0	1313421.JHBV01000042_gene3333	9.721e-92	311.0	COG4221@1|root,COG4221@2|Bacteria,4PMDB@976|Bacteroidetes	976|Bacteroidetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_606591_0	439235.Dalk_4289	2.115e-132	435.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria,2MJBT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS3_k127_606591_1	1144275.COCOR_07005	1.182e-27	117.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WRH2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
TLS3_k127_6086134_1	653948.CCA22752	1.381e-06	54.0	COG0578@1|root,KOG0042@2759|Eukaryota	2759|Eukaryota	C	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS3_k127_6086134_0	1469948.JPNB01000002_gene3810	2.113e-54	203.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,36DWB@31979|Clostridiaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS3_k127_6101194_1	700598.Niako_5514	1.837e-10	65.0	COG0355@1|root,COG0355@2|Bacteria,4NUYG@976|Bacteroidetes,1ITVV@117747|Sphingobacteriia	976|Bacteroidetes	C	ATP synthase	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS3_k127_6101194_0	768670.Calni_1587	5.271e-219	687.0	COG0055@1|root,COG0055@2|Bacteria,2GEQN@200930|Deferribacteres	200930|Deferribacteres	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS3_k127_6106842_0	156889.Mmc1_2224	8.572e-105	348.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	BQ	Including yeast histone deacetylase and acetoin utilization protein	hdaH	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS3_k127_6106842_2	502025.Hoch_4226	6.731e-25	111.0	COG1075@1|root,COG1075@2|Bacteria,1R75P@1224|Proteobacteria,42QNM@68525|delta/epsilon subdivisions,2WN41@28221|Deltaproteobacteria,2Z16B@29|Myxococcales	28221|Deltaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
TLS3_k127_6106842_3	209285.XP_006693336.1	1.36e-05	56.0	COG0596@1|root,KOG2382@2759|Eukaryota,39UJH@33154|Opisthokonta,3NY7B@4751|Fungi,3QM16@4890|Ascomycota,214YG@147550|Sordariomycetes,3U8C0@5139|Sordariales,3H9IC@35718|Chaetomiaceae	4751|Fungi	S	Serine aminopeptidase, S33	-	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008474,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019752,GO:0032787,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704,GO:0098599,GO:0098732,GO:0098734,GO:0140096	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_6106842_1	448385.sce8975	2.082e-32	136.0	COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria,438KV@68525|delta/epsilon subdivisions,2X3V8@28221|Deltaproteobacteria,2YX7K@29|Myxococcales	28221|Deltaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_6115901_1	2325.TKV_c11020	5.209e-22	110.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,42H69@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_20,CBM_48,DUF3372,PUD
TLS3_k127_6115901_0	483219.LILAB_34710	2.035e-211	688.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2YX6F@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS3_k127_611625_0	383372.Rcas_1775	4.115e-134	439.0	COG0318@1|root,COG0318@2|Bacteria,2G7VC@200795|Chloroflexi	200795|Chloroflexi	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS3_k127_6126428_4	224325.AF_0676	1.124e-26	109.0	COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,246UX@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
TLS3_k127_6126428_5	1118235.CAJH01000022_gene1367	1.757e-21	96.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1X668@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
TLS3_k127_6126428_0	428125.CLOLEP_01014	1.957e-81	279.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3WGEW@541000|Ruminococcaceae	186801|Clostridia	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS3_k127_6126428_6	378806.STAUR_3761	6.031e-12	66.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2WSYK@28221|Deltaproteobacteria,2YW0P@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS3_k127_6126428_2	1191523.MROS_0192	2.281e-46	169.0	COG0099@1|root,COG0099@2|Bacteria	2|Bacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
TLS3_k127_6126428_3	889378.Spiaf_0576	1.017e-44	166.0	COG0100@1|root,COG0100@2|Bacteria,2J7BP@203691|Spirochaetes	203691|Spirochaetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
TLS3_k127_6126428_1	1304880.JAGB01000003_gene1185	1.466e-47	173.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS3_k127_61312_0	857087.Metme_3564	3.117e-25	107.0	COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,1S32X@1236|Gammaproteobacteria,1XGBP@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
TLS3_k127_6136550_1	439235.Dalk_0029	7.376e-49	189.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_6136550_0	1298593.TOL_1107	6.482e-299	935.0	28M78@1|root,2ZAKQ@2|Bacteria,1MXD9@1224|Proteobacteria,1SMTX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6146280_0	907348.TresaDRAFT_1951	2.351e-69	251.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_6153802_4	2711.XP_006477810.1	3.91e-24	105.0	COG0385@1|root,KOG2718@2759|Eukaryota,37PAH@33090|Viridiplantae,3G9UB@35493|Streptophyta	35493|Streptophyta	P	sodium metabolite cotransporter BASS1	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009536,GO:0009941,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
TLS3_k127_6153802_0	313606.M23134_04790	3.888e-108	362.0	COG1054@1|root,COG1054@2|Bacteria,4NEG6@976|Bacteroidetes,47JH6@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the UPF0176 family	yceA	-	-	ko:K07146	-	-	-	-	ko00000	-	-	-	Rhodanese,Rhodanese_C
TLS3_k127_6153802_2	439235.Dalk_2689	3.536e-42	172.0	2ESJJ@1|root,33K47@2|Bacteria,1NJZA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6153802_5	159087.Daro_1058	2.392e-06	52.0	COG2906@1|root,COG2906@2|Bacteria,1NGGY@1224|Proteobacteria,2VWVZ@28216|Betaproteobacteria,2KX62@206389|Rhodocyclales	206389|Rhodocyclales	P	BFD-like [2Fe-2S] binding domain	bfd	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
TLS3_k127_6153802_1	1162668.LFE_0390	2.006e-45	170.0	COG0663@1|root,COG0663@2|Bacteria,3J121@40117|Nitrospirae	40117|Nitrospirae	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS3_k127_6153802_3	1168034.FH5T_08040	2.934e-32	135.0	COG4276@1|root,COG4276@2|Bacteria,4NQJG@976|Bacteroidetes	976|Bacteroidetes	S	SRPBCC domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS3_k127_6165600_0	1216976.AX27061_2704	3.659e-12	68.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,2VSHN@28216|Betaproteobacteria,3T5FG@506|Alcaligenaceae	28216|Betaproteobacteria	M	NlpC P60 family protein	-	-	-	ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
TLS3_k127_6192340_0	402612.FP0618	7.88e-58	206.0	COG3781@1|root,COG3781@2|Bacteria,4NEB1@976|Bacteroidetes,1HYDP@117743|Flavobacteriia,2NSGY@237|Flavobacterium	976|Bacteroidetes	S	membrane	-	-	-	ko:K08994	-	-	-	-	ko00000,ko02000	1.A.46.2	-	-	Bestrophin
TLS3_k127_6192340_1	379066.GAU_0425	8.095e-56	211.0	COG1132@1|root,COG1132@2|Bacteria,1ZUSI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
TLS3_k127_6193728_1	1210884.HG799462_gene8813	2.93e-38	157.0	COG1012@1|root,COG2208@1|root,COG1012@2|Bacteria,COG2208@2|Bacteria,2J30Q@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
TLS3_k127_6193728_2	1500897.JQNA01000002_gene83	5.241e-12	76.0	COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,2VSAM@28216|Betaproteobacteria,1K6NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_6193728_0	448385.sce3967	5.756e-67	238.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1NI1E@1224|Proteobacteria,430IZ@68525|delta/epsilon subdivisions,2WW3C@28221|Deltaproteobacteria,2YYH1@29|Myxococcales	28221|Deltaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_M10
TLS3_k127_6218675_1	316067.Geob_3253	2.684e-15	90.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS3_k127_6218675_0	697282.Mettu_1987	5.784e-25	122.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	3.4.14.5	ko:K01278,ko:K03561,ko:K12287	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
TLS3_k127_6219415_1	59374.Fisuc_2276	4.086e-25	107.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_6219415_0	761193.Runsl_2861	5.273e-44	166.0	COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,47JCA@768503|Cytophagia	976|Bacteroidetes	S	ABC transporter	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS3_k127_6239944_4	1492738.FEM21_03830	5.055e-25	104.0	COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,1HWUI@117743|Flavobacteriia,2NTDC@237|Flavobacterium	976|Bacteroidetes	P	heavy metal translocating P-type ATPase	silP	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_6239944_2	595460.RRSWK_02048	1.324e-55	204.0	COG0398@1|root,COG0398@2|Bacteria,2J2ZN@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,SNARE_assoc
TLS3_k127_6239944_3	419947.MRA_1687	1.507e-44	167.0	COG1225@1|root,COG1225@2|Bacteria,2IIDG@201174|Actinobacteria,239TX@1762|Mycobacteriaceae	201174|Actinobacteria	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,AhpC-TSA_2
TLS3_k127_6239944_0	67267.JNXT01000017_gene7217	1.141e-150	484.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS3_k127_6239944_1	666685.R2APBS1_3815	4.675e-57	201.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1X8WG@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Radical_SAM
TLS3_k127_6255711_1	395495.Lcho_1671	3.654e-55	198.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,1KJ78@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	endonuclease III	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
TLS3_k127_6255711_4	1289135.A966_10482	1.754e-17	94.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M23
TLS3_k127_6255711_0	760192.Halhy_1720	6.625e-80	276.0	COG0463@1|root,COG0463@2|Bacteria,4PKIQ@976|Bacteroidetes,1J0WP@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_6255711_2	1089553.Tph_c28990	3.814e-46	173.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,42F7S@68295|Thermoanaerobacterales	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
TLS3_k127_6255711_5	481448.Minf_1672	6.295e-07	55.0	COG0718@1|root,COG0718@2|Bacteria,46TA9@74201|Verrucomicrobia,37GYJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS3_k127_6255711_3	385682.AFSL01000063_gene1540	6.95e-29	131.0	COG0457@1|root,COG2885@1|root,COG0457@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,2FPU5@200643|Bacteroidia,3XIWE@558415|Marinilabiliaceae	976|Bacteroidetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
TLS3_k127_6256906_6	443143.GM18_0649	1.101e-10	63.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria	1224|Proteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
TLS3_k127_6256906_2	661478.OP10G_1239	6.816e-49	179.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,Polyketide_cyc2
TLS3_k127_6256906_0	509635.N824_18585	2.564e-94	313.0	COG0262@1|root,COG0262@2|Bacteria,4P1JF@976|Bacteroidetes	976|Bacteroidetes	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS3_k127_6256906_3	796606.BMMGA3_09755	2.861e-44	168.0	COG3832@1|root,COG3832@2|Bacteria,1V352@1239|Firmicutes,4HIVF@91061|Bacilli,1ZDWI@1386|Bacillus	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_6256906_4	1298867.AUES01000007_gene5094	9.191e-43	162.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria,3JSA3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS3_k127_6256906_1	1121930.AQXG01000001_gene1237	2.096e-58	206.0	COG3832@1|root,COG3832@2|Bacteria,4NQ4A@976|Bacteroidetes,1ISRX@117747|Sphingobacteriia	976|Bacteroidetes	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_6256906_5	580332.Slit_2322	2.412e-39	151.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2VU68@28216|Betaproteobacteria	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS3_k127_6256906_7	870187.Thini_1988	0.0009772	47.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631,DUF2510,PknH_C,TIR_2
TLS3_k127_6258340_0	643867.Ftrac_2927	9.903e-41	172.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NHCE@976|Bacteroidetes,47X9U@768503|Cytophagia	976|Bacteroidetes	MU	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_11,TPR_16
TLS3_k127_6264719_0	91464.S7335_60	1.987e-53	203.0	COG0553@1|root,COG3886@1|root,COG0553@2|Bacteria,COG3886@2|Bacteria,1FZVD@1117|Cyanobacteria,1H3XN@1129|Synechococcus	1117|Cyanobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,ResIII,SNF2_N
TLS3_k127_6267007_0	323261.Noc_1391	2.9e-52	192.0	COG5285@1|root,COG5285@2|Bacteria,1N31I@1224|Proteobacteria,1SDAB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.46	ko:K21195	ko00440,map00440	-	R10724	RC01107	ko00000,ko00001,ko01000	-	-	-	PhyH
TLS3_k127_6267007_1	335543.Sfum_2230	9.15e-36	143.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2MRQ4@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6268587_0	1121904.ARBP01000001_gene5647	6.422e-124	405.0	COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,47KXJ@768503|Cytophagia	976|Bacteroidetes	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	oorB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS3_k127_6271169_1	335541.Swol_0171	6.432e-17	97.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CARDB,Calx-beta,LRR_5,PKD,SLH
TLS3_k127_6271169_0	1005994.GTGU_02468	4.445e-32	147.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T2KS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
TLS3_k127_6275833_0	401053.AciPR4_0321	4.779e-85	290.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria,2JHTJ@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS3_k127_6275833_1	1384066.JAGT01000001_gene93	3.264e-43	160.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,3WJM9@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
TLS3_k127_6278219_1	1123508.JH636441_gene3255	8.861e-22	101.0	COG0095@1|root,COG0095@2|Bacteria,2J0D8@203682|Planctomycetes	203682|Planctomycetes	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS3_k127_6278219_2	1079460.ATTQ01000020_gene4371	3.906e-07	55.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,4BFBV@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Belongs to the BolA IbaG family	bolA	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564	-	ko:K05527,ko:K22066	-	-	-	-	ko00000,ko03000,ko03029	-	-	-	BolA
TLS3_k127_6278219_0	1131269.AQVV01000017_gene1969	1.082e-85	307.0	COG0458@1|root,COG1304@1|root,COG0458@2|Bacteria,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	lldD	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,FMN_dh
TLS3_k127_6286421_2	665571.STHERM_c12220	1.901e-26	113.0	COG2703@1|root,COG2703@2|Bacteria,2J7CC@203691|Spirochaetes	203691|Spirochaetes	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_6286421_1	889378.Spiaf_0607	3.238e-32	128.0	COG2201@1|root,COG2201@2|Bacteria,2JAI9@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS3_k127_6286421_0	889378.Spiaf_0608	4.117e-38	147.0	COG1406@1|root,COG1406@2|Bacteria,2JAIP@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
TLS3_k127_6286421_3	330214.NIDE1690	9.649e-15	84.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CZB,MCPsignal,dCache_1
TLS3_k127_6315475_2	744872.Spica_0482	0.0001	51.0	COG2206@1|root,COG2206@2|Bacteria,2J6GF@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
TLS3_k127_6315475_0	509190.Cseg_2194	3.046e-05	49.0	COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,2UBW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FlhB HrpN YscU SpaS Family	MA20_35465	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
TLS3_k127_6315475_1	1121355.KB903379_gene745	3.745e-05	46.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS3_k127_631631_1	573413.Spirs_2083	6.426e-39	152.0	COG1235@1|root,COG1235@2|Bacteria,2J5C5@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_631631_0	56780.SYN_01458	3.391e-43	165.0	COG2095@1|root,COG2095@2|Bacteria,1QS1D@1224|Proteobacteria,4348G@68525|delta/epsilon subdivisions,2X9X6@28221|Deltaproteobacteria,2MSBJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TLS3_k127_631631_2	631362.Thi970DRAFT_01310	1.401e-15	84.0	COG4194@1|root,COG4194@2|Bacteria,1QTGM@1224|Proteobacteria,1SVXJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
TLS3_k127_631631_3	1403819.BATR01000025_gene833	5.346e-08	60.0	COG1572@1|root,COG2010@1|root,COG2133@1|root,COG1572@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,46TW3@74201|Verrucomicrobia,2IVDX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS3_k127_63188_2	891391.LAC30SC_07855	6.1e-08	58.0	COG0702@1|root,COG0702@2|Bacteria,1TQFS@1239|Firmicutes,4HDA2@91061|Bacilli,3F521@33958|Lactobacillaceae	91061|Bacilli	GM	NAD(P)H-binding	ylbE	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS3_k127_63188_0	1379270.AUXF01000001_gene1972	2.161e-46	179.0	COG2207@1|root,COG2207@2|Bacteria,1ZV3F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
TLS3_k127_63188_1	1446473.JHWH01000008_gene85	2.583e-14	81.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2TV0F@28211|Alphaproteobacteria,2PWQ8@265|Paracoccus	28211|Alphaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	hbaR	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_632334_0	195105.CN97_00740	0.0009561	52.0	295SR@1|root,2ZT41@2|Bacteria,1RF8D@1224|Proteobacteria,2U701@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6326379_0	525904.Tter_0474	0.0	1098.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2NP08@2323|unclassified Bacteria	2|Bacteria	E	Glutamate synthase central domain	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS3_k127_6329746_0	714943.Mucpa_5270	1.821e-68	243.0	COG2896@1|root,COG2896@2|Bacteria,4NFS9@976|Bacteroidetes,1IPUJ@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22,4.6.1.17	ko:K03639,ko:K20967	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394,R11372	RC03420,RC03425	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TLS3_k127_6330630_0	1170562.Cal6303_3232	2.47e-30	127.0	COG0625@1|root,COG0625@2|Bacteria,1G5EX@1117|Cyanobacteria,1HT23@1161|Nostocales	1117|Cyanobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
TLS3_k127_6330630_1	1453501.JELR01000002_gene304	3.183e-09	64.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,1QU7V@1224|Proteobacteria,1T1QA@1236|Gammaproteobacteria,46693@72275|Alteromonadaceae	1236|Gammaproteobacteria	KT	COG0784 FOG CheY-like receiver	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
TLS3_k127_6332603_0	945713.IALB_0720	4.693e-86	300.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	fixI	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_6334162_0	398767.Glov_2538	1.026e-261	826.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS3_k127_6337530_0	1307761.L21SP2_2609	0.0004698	53.0	COG0457@1|root,COG0457@2|Bacteria	1307761.L21SP2_2609|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6340198_1	658187.LDG_5821	2.496e-21	104.0	COG4097@1|root,COG4097@2|Bacteria	2|Bacteria	P	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
TLS3_k127_6340198_0	313603.FB2170_06750	2.433e-52	187.0	2C1EG@1|root,2Z7MZ@2|Bacteria,4NYQE@976|Bacteroidetes,1IBSY@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6363305_1	868864.Dester_0119	6.293e-67	230.0	COG0458@1|root,COG0458@2|Bacteria,2G3RR@200783|Aquificae	200783|Aquificae	F	PFAM Carbamoyl-phosphate synthase L chain	carB2	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS3_k127_6363305_0	381666.H16_A2781	6.099e-69	244.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2VHM0@28216|Betaproteobacteria,1K3NS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	phenazine biosynthesis protein PhzF family	phzF_1	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
TLS3_k127_6363305_2	1191523.MROS_0708	1.079e-40	158.0	2D6MI@1|root,32TMJ@2|Bacteria	2|Bacteria	S	PAP2 superfamily C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_C
TLS3_k127_6363305_4	1121447.JONL01000001_gene603	1.219e-10	64.0	COG0642@1|root,COG2114@1|root,COG2114@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07648	ko02020,ko02026,map02020,map02026	M00456	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HWE_HK,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
TLS3_k127_6372499_0	1397527.Q670_04270	7.587e-82	288.0	2DB8Y@1|root,2Z7TF@2|Bacteria,1MW4C@1224|Proteobacteria,1RQC5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
TLS3_k127_6372499_2	196627.cg2625	3.434e-45	181.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,22JVE@1653|Corynebacteriaceae	201174|Actinobacteria	I	Belongs to the thiolase family	pcaF	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_6372499_1	1226994.AMZB01000088_gene915	9.226e-67	233.0	COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,1S4S3@1236|Gammaproteobacteria,1YDSS@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TLS3_k127_6372499_7	675817.VDA_000482	6.946e-05	49.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria,1XVBQ@135623|Vibrionales	135623|Vibrionales	C	Molydopterin dinucleotide binding domain	-	-	1.7.2.3	ko:K07812	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.4	-	-	Molybdopterin,Molydop_binding
TLS3_k127_6372499_6	929562.Emtol_1812	9.629e-07	57.0	COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,47JZP@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369,Thioredoxin_8
TLS3_k127_6372499_4	204669.Acid345_4557	1.013e-11	76.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,Cadherin_3,Calx-beta,DUF4347,He_PIG,Invasin_D3,Laminin_G_3,Lectin_C,PA14,Pentaxin,Peptidase_S74
TLS3_k127_6372499_3	765913.ThidrDRAFT_1281	4.452e-20	96.0	COG0526@1|root,COG0526@2|Bacteria,1RJUZ@1224|Proteobacteria,1S6Y0@1236|Gammaproteobacteria,1WYNQ@135613|Chromatiales	135613|Chromatiales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS3_k127_6372499_5	1283300.ATXB01000001_gene1440	3.96e-08	66.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	csgG	-	-	-	-	-	-	-	-	-	-	-	CsgG,DUF4384,PG_binding_1
TLS3_k127_6376769_1	269798.CHU_1041	4.047e-14	73.0	COG0288@1|root,COG0288@2|Bacteria,4NEJT@976|Bacteroidetes,47PCQ@768503|Cytophagia	976|Bacteroidetes	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS3_k127_6376769_0	240016.ABIZ01000001_gene1216	1.122e-177	573.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_8,Response_reg
TLS3_k127_6377160_0	471852.Tcur_4391	5.861e-234	739.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4EFQQ@85012|Streptosporangiales	201174|Actinobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS3_k127_6377160_1	1122134.KB893650_gene1149	6.933e-16	77.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1XKU9@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
TLS3_k127_6380484_2	1519464.HY22_02350	0.0001347	54.0	COG0457@1|root,COG0457@2|Bacteria,1FDVB@1090|Chlorobi	1090|Chlorobi	S	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
TLS3_k127_6380484_0	316274.Haur_0080	1.047e-48	186.0	COG0726@1|root,COG0726@2|Bacteria,2G8CG@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
TLS3_k127_6380484_1	1469607.KK073768_gene1344	3.822e-26	113.0	COG0664@1|root,COG0664@2|Bacteria,1G57E@1117|Cyanobacteria,1HN55@1161|Nostocales	1117|Cyanobacteria	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS3_k127_6400875_0	402777.KB235903_gene774	1.311e-88	304.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
TLS3_k127_6405103_2	1282362.AEAC466_17700	3.042e-27	115.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,2KGMA@204458|Caulobacterales	204458|Caulobacterales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
TLS3_k127_6405103_0	1123250.KB908380_gene764	2.487e-58	207.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,4H3Z2@909932|Negativicutes	909932|Negativicutes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
TLS3_k127_6405103_3	1267005.KB911261_gene2225	4.619e-16	82.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,3N6ZG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
TLS3_k127_6405103_1	373903.Hore_01340	7.614e-55	196.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,3WAKQ@53433|Halanaerobiales	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
TLS3_k127_6410817_0	667014.Thein_1066	3.398e-59	216.0	COG0196@1|root,COG0196@2|Bacteria,2GGTF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Riboflavin kinase	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS3_k127_6417580_0	1379270.AUXF01000005_gene720	3.81e-54	197.0	COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS3_k127_6426582_1	715451.ambt_13390	4.12e-28	118.0	COG5285@1|root,COG5285@2|Bacteria,1QRDD@1224|Proteobacteria,1RQ6U@1236|Gammaproteobacteria,468YT@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS3_k127_6426582_0	1183438.GKIL_2249	5.83e-30	126.0	COG3555@1|root,COG3555@2|Bacteria,1G0W9@1117|Cyanobacteria	1117|Cyanobacteria	O	Aspartyl asparaginyl beta-hydroxylase	-	-	-	ko:K12979	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Asp_Arg_Hydrox
TLS3_k127_6426582_2	28583.AMAG_02445T0	2.936e-17	91.0	KOG2132@1|root,KOG2132@2759|Eukaryota,38CB5@33154|Opisthokonta,3NZH4@4751|Fungi	4751|Fungi	BT	JmjC domain-containing protein	-	-	1.14.11.27	ko:K10277	-	-	-	-	ko00000,ko01000,ko03036	-	-	-	Cupin_8
TLS3_k127_6429692_2	697303.Thewi_2228	7.448e-10	61.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,42ENH@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
TLS3_k127_6429692_0	706587.Desti_5288	2.393e-82	285.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MR47@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS3_k127_6429692_1	264951.V5FZZ9	2.801e-11	67.0	COG0203@1|root,KOG3280@2759|Eukaryota,3A5T5@33154|Opisthokonta,3P1YY@4751|Fungi,3QUMN@4890|Ascomycota,20EV4@147545|Eurotiomycetes,3S7UV@5042|Eurotiales	4751|Fungi	J	Belongs to the bacterial ribosomal protein bL17 family	mrpl8	GO:0000002,GO:0000313,GO:0000315,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0071840,GO:0098798,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS3_k127_6446107_1	595460.RRSWK_01989	7.307e-12	74.0	COG4615@1|root,COG4615@2|Bacteria,2J2MM@203682|Planctomycetes	203682|Planctomycetes	PQ	ABC transporter transmembrane region	-	-	-	ko:K06159,ko:K06160	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.113.2,3.A.1.113.3	-	-	ABC_membrane,ABC_tran
TLS3_k127_6446107_0	1408445.JHXP01000039_gene3366	4.907e-33	139.0	COG3754@1|root,COG5010@1|root,COG3754@2|Bacteria,COG5010@2|Bacteria,1PDZM@1224|Proteobacteria,1SJD3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Rhamnan synthesis protein F	-	-	-	ko:K07272	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	RgpF
TLS3_k127_6449487_3	1123372.AUIT01000010_gene398	7.384e-11	72.0	COG1544@1|root,COG1544@2|Bacteria,2GHW9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS3_k127_6449487_0	1308866.J416_00614	3.883e-83	286.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,4HAXR@91061|Bacilli,470E3@74385|Gracilibacillus	91061|Bacilli	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
TLS3_k127_6449487_2	1209989.TepiRe1_0766	7.059e-24	103.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,42GZ3@68295|Thermoanaerobacterales	186801|Clostridia	G	phosphocarrier	ptsH	-	-	ko:K11184,ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TLS3_k127_6449487_1	522772.Dacet_0450	1.211e-24	108.0	COG2089@1|root,COG2089@2|Bacteria,2GF5V@200930|Deferribacteres	200930|Deferribacteres	M	PFAM N-acetylneuraminic acid synthase domain	-	-	2.5.1.101,2.5.1.56	ko:K01654,ko:K18430	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R10304	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
TLS3_k127_6452156_1	1278073.MYSTI_02814	1.098e-07	65.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	BSP,Bac_surface_Ag,PD40
TLS3_k127_6452156_0	1286106.MPL1_07378	4.734e-08	59.0	COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,1S3KK@1236|Gammaproteobacteria,46150@72273|Thiotrichales	72273|Thiotrichales	E	Spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
TLS3_k127_6455518_0	61459.XP_007781095.1	9.436e-23	110.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3Q63G@4751|Fungi,3R19X@4890|Ascomycota,20UR9@147545|Eurotiomycetes	4751|Fungi	M	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4
TLS3_k127_6455518_1	112098.XP_008615426.1	3.54e-11	75.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Pkinase,Pkinase_Tyr
TLS3_k127_6457760_0	382464.ABSI01000013_gene1716	1.085e-40	158.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_6457760_1	1506583.JQJY01000007_gene4109	8.461e-19	91.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZ3N@117743|Flavobacteriia,2NXGC@237|Flavobacterium	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_6474284_0	349521.HCH_03194	2.625e-39	170.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1T42Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	outer membrane autotransporter barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
TLS3_k127_6481000_1	706587.Desti_3932	3.767e-09	59.0	COG0784@1|root,COG2197@1|root,COG3852@1|root,COG0784@2|Bacteria,COG2197@2|Bacteria,COG3852@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	bphP	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,HWE_HK,PAS_2,PAS_3,PAS_4,PHY,Response_reg
TLS3_k127_6481000_0	204669.Acid345_1150	4.992e-46	177.0	arCOG09454@1|root,31B41@2|Bacteria,3Y8HD@57723|Acidobacteria,2JNG1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6482797_1	1192124.LIG30_4797	0.0005459	51.0	COG0457@1|root,COG0457@2|Bacteria,1RKBA@1224|Proteobacteria,2WA1N@28216|Betaproteobacteria,1KEEP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
TLS3_k127_6487177_1	1042376.AFPK01000045_gene2717	1.179e-31	133.0	COG1835@1|root,COG1835@2|Bacteria,4NMNZ@976|Bacteroidetes,1HXKH@117743|Flavobacteriia,4075G@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	I	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
TLS3_k127_6487177_0	497964.CfE428DRAFT_2397	1.378e-109	364.0	COG1858@1|root,COG1858@2|Bacteria,46SJU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Di-haem cytochrome c peroxidase	mauG	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS3_k127_6495944_1	166318.Syn8016DRAFT_1077	4.851e-23	108.0	COG0083@1|root,COG0083@2|Bacteria,1G1AH@1117|Cyanobacteria,1GZAJ@1129|Synechococcus	1117|Cyanobacteria	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.thrB	GHMP_kinases_C,GHMP_kinases_N
TLS3_k127_6495944_2	667121.ET1_14_02020	3.245e-10	65.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Involved in resistance toward heavy metals	cutA	GO:0003674,GO:0005488,GO:0005507,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS3_k127_6495944_0	1047013.AQSP01000132_gene1749	5.714e-62	224.0	COG0123@1|root,COG0123@2|Bacteria,2NPPE@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS3_k127_6497722_0	756067.MicvaDRAFT_3536	8.79e-26	119.0	COG0553@1|root,COG3886@1|root,COG0553@2|Bacteria,COG3886@2|Bacteria,1FZVD@1117|Cyanobacteria	1117|Cyanobacteria	L	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,ResIII,SNF2_N
TLS3_k127_6517157_0	1242864.D187_008157	1.019e-61	237.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2X2JP@28221|Deltaproteobacteria,2YY11@29|Myxococcales	28221|Deltaproteobacteria	S	A-macroglobulin complement component	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
TLS3_k127_6544874_0	1121033.AUCF01000002_gene556	5.859e-284	882.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,2JQA4@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrd	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS3_k127_6547356_0	1114972.AUAW01000007_gene2521	2.197e-53	203.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,3F4KU@33958|Lactobacillaceae	91061|Bacilli	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS3_k127_6550047_0	478741.JAFS01000001_gene2028	8.029e-37	146.0	COG4798@1|root,COG4798@2|Bacteria,46T4I@74201|Verrucomicrobia,37GDY@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Met-10+ like-protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS3_k127_6550047_1	398512.JQKC01000017_gene3035	7.305e-07	54.0	2DR1B@1|root,339RX@2|Bacteria,1VKXF@1239|Firmicutes,259K6@186801|Clostridia,3WQAI@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6550047_2	1235835.C814_00407	0.0001622	48.0	COG0340@1|root,COG0340@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,3WHDB@541000|Ruminococcaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
TLS3_k127_6553768_0	37659.JNLN01000001_gene1752	1.698e-71	258.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,36E8U@31979|Clostridiaceae	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
TLS3_k127_6556119_4	1216966.BAUC01000010_gene2315	9.227e-21	93.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	iECH74115_1262.ECH74115_2481,iECSP_1301.ECSP_2329,iECs_1301.ECs2467,iG2583_1286.G2583_2207,iPC815.YPO3971,iSDY_1059.SDY_1514,iYL1228.KPN_01210,iZ_1308.Z2793	ELFV_dehydrog,ELFV_dehydrog_N
TLS3_k127_6556119_0	760154.Sulba_1517	2.453e-46	188.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2YP81@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_6556119_3	43989.cce_0691	5.204e-29	117.0	COG1942@1|root,COG1942@2|Bacteria,1G9PD@1117|Cyanobacteria	1117|Cyanobacteria	G	4-oxalocrotonate tautomerase family	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
TLS3_k127_6556119_1	1121423.JONT01000009_gene1452	8.494e-36	148.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,2631B@186807|Peptococcaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_6556119_6	493475.GARC_0444	3.798e-05	54.0	2CB8S@1|root,32W8V@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4199)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4199
TLS3_k127_6556119_2	338963.Pcar_1325	6.924e-32	133.0	COG0461@1|root,COG0461@2|Bacteria,1PI8N@1224|Proteobacteria,42QSR@68525|delta/epsilon subdivisions,2WMT5@28221|Deltaproteobacteria,43SF3@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphoribosyl transferase domain	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS3_k127_6556119_5	714943.Mucpa_2985	8.495e-12	73.0	COG2353@1|root,COG2353@2|Bacteria,4NQKY@976|Bacteroidetes,1IT9I@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS3_k127_6561334_1	331678.Cphamn1_1828	3.751e-25	115.0	COG0558@1|root,COG0558@2|Bacteria,1FDVM@1090|Chlorobi	1090|Chlorobi	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS3_k127_6561334_0	1123355.JHYO01000007_gene482	4.107e-61	213.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,36XVR@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	bhbA	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS3_k127_6571274_2	755732.Fluta_1593	1.629e-05	48.0	COG0745@1|root,COG0745@2|Bacteria,4NGXP@976|Bacteroidetes,1IG0I@117743|Flavobacteriia,2PBMZ@246874|Cryomorphaceae	976|Bacteroidetes	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_6571274_0	309801.trd_1384	1.48e-72	257.0	COG0407@1|root,COG0407@2|Bacteria,2G5NU@200795|Chloroflexi,27XWH@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS3_k127_6571274_1	1220583.GOACH_05_01010	1.169e-13	81.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4GBVM@85026|Gordoniaceae	201174|Actinobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS3_k127_6575456_1	585531.HMPREF0063_13042	6.708e-32	126.0	COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria,4DQ7S@85009|Propionibacteriales	201174|Actinobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
TLS3_k127_6575456_0	1246626.BleG1_0040	5.563e-69	241.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,4HAUR@91061|Bacilli,1ZBA9@1386|Bacillus	91061|Bacilli	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
TLS3_k127_6575456_2	1268239.PALB_36420	2.845e-23	102.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,2Q2DB@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
TLS3_k127_6578301_0	309801.trd_1740	5.411e-312	979.0	COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,27XGQ@189775|Thermomicrobia	189775|Thermomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
TLS3_k127_6578301_1	595460.RRSWK_02400	1.425e-43	175.0	COG0786@1|root,COG0786@2|Bacteria	2|Bacteria	P	glutamate:sodium symporter activity	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
TLS3_k127_6578301_4	749927.AMED_7413	2.001e-05	58.0	COG2730@1|root,COG2755@1|root,COG5297@1|root,COG2730@2|Bacteria,COG2755@2|Bacteria,COG5297@2|Bacteria,2GKTY@201174|Actinobacteria,4DYMC@85010|Pseudonocardiales	201174|Actinobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CBM_10,CBM_2,Cellulase,Lipase_GDSL_2,fn3
TLS3_k127_6578301_3	483219.LILAB_30960	4.21e-07	64.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,CHAP,CHB_HEX_C_1,Cytochrome_cB,F5_F8_type_C,He_PIG,PKD,SBBP
TLS3_k127_6578301_2	177437.HRM2_45380	1.493e-11	72.0	COG1262@1|root,COG1262@2|Bacteria,1R6GS@1224|Proteobacteria,42R3Z@68525|delta/epsilon subdivisions,2WN4D@28221|Deltaproteobacteria,2MJKG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
TLS3_k127_6579024_1	1122176.KB903531_gene3128	8.762e-45	167.0	COG3000@1|root,COG3000@2|Bacteria,4NMKR@976|Bacteroidetes,1ISPG@117747|Sphingobacteriia	976|Bacteroidetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_6579024_2	1504672.669784924	1.639e-14	78.0	COG1848@1|root,COG1848@2|Bacteria,1N5DS@1224|Proteobacteria,2W2KD@28216|Betaproteobacteria,4AHW8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_6579024_3	1122603.ATVI01000005_gene3430	2.747e-07	55.0	COG4118@1|root,COG4118@2|Bacteria,1NH4W@1224|Proteobacteria,1T11U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS3_k127_6579024_0	204669.Acid345_2742	2.572e-252	785.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y2FA@57723|Acidobacteria,2JI4J@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
TLS3_k127_6581765_0	1278073.MYSTI_06804	1.873e-32	141.0	COG4775@1|root,COG4775@2|Bacteria,1QUE3@1224|Proteobacteria,430IG@68525|delta/epsilon subdivisions,2WVP9@28221|Deltaproteobacteria,2YVI0@29|Myxococcales	28221|Deltaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
TLS3_k127_6584614_1	264462.Bd0930	9.309e-79	271.0	COG0693@1|root,COG0693@2|Bacteria,1NBJV@1224|Proteobacteria,437IR@68525|delta/epsilon subdivisions,2MTRY@213481|Bdellovibrionales,2X2SJ@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	ThiJ/PfpI family-like	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ThiJ_like
TLS3_k127_6584614_3	1144275.COCOR_04749	6.923e-09	60.0	2E00G@1|root,32VPX@2|Bacteria,1RJ37@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6584614_0	502025.Hoch_1795	2.447e-93	314.0	COG2159@1|root,COG2159@2|Bacteria,1Q4Y5@1224|Proteobacteria,4304H@68525|delta/epsilon subdivisions,2WVAR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS3_k127_6584614_4	1268239.PALB_2180	1.025e-08	66.0	COG2931@1|root,COG2931@2|Bacteria,1R6WW@1224|Proteobacteria,1SRAH@1236|Gammaproteobacteria,2PZEY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	Q	Protein of unknown function (DUF642)	-	-	-	-	-	-	-	-	-	-	-	-	DUF642
TLS3_k127_6584614_5	1121930.AQXG01000004_gene2837	8.943e-07	55.0	COG4691@1|root,COG4691@2|Bacteria	2|Bacteria	S	Plasmid stability protein	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	Arc
TLS3_k127_6584614_2	102125.Xen7305DRAFT_00000310	1.616e-36	142.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_6585455_0	906968.Trebr_0771	1.696e-50	195.0	COG2199@1|root,COG3706@2|Bacteria,2J8FW@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF,Response_reg
TLS3_k127_6585455_1	1423144.Gal_02843	9.786e-16	87.0	29681@1|root,2ZTI1@2|Bacteria,1RA8W@1224|Proteobacteria,2U6CU@28211|Alphaproteobacteria,34E2V@302485|Phaeobacter	28211|Alphaproteobacteria	S	Peptidase M50B-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
TLS3_k127_6588556_0	467200.ACFA01000915_gene3437	4.572e-66	231.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS3_k127_6588556_1	639282.DEFDS_1483	6.631e-19	94.0	COG0328@1|root,COG0328@2|Bacteria,2GFX8@200930|Deferribacteres	200930|Deferribacteres	L	Reverse transcriptase-like	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
TLS3_k127_6596740_4	449447.MAE_12790	9.599e-28	117.0	COG2402@1|root,COG2402@2|Bacteria,1G8Q4@1117|Cyanobacteria	1117|Cyanobacteria	S	nucleic acid-binding protein contains PIN domain	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
TLS3_k127_6596740_1	195250.CM001776_gene2144	1.852e-63	229.0	COG4974@1|root,COG4974@2|Bacteria,1G4JW@1117|Cyanobacteria,1GZF3@1129|Synechococcus	1117|Cyanobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS3_k127_6596740_2	1340493.JNIF01000003_gene2067	4.557e-63	228.0	COG4974@1|root,COG4974@2|Bacteria,3Y3D0@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS3_k127_6596740_0	1340493.JNIF01000003_gene2060	1.248e-132	457.0	COG0358@1|root,COG0358@2|Bacteria	2|Bacteria	L	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,Toprim_N,zf-CHC2
TLS3_k127_6596740_5	406818.XBJ1_1302	1.937e-26	112.0	COG1396@1|root,COG1396@2|Bacteria,1R044@1224|Proteobacteria,1S8G2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS3_k127_6596740_6	1086011.HJ01_03273	1.742e-17	90.0	2AV1M@1|root,31KRG@2|Bacteria,4PDF7@976|Bacteroidetes,1IDXF@117743|Flavobacteriia,2NZET@237|Flavobacterium	976|Bacteroidetes	S	Super-infection exclusion protein B	-	-	-	-	-	-	-	-	-	-	-	-	SieB
TLS3_k127_6596740_3	96561.Dole_1703	1.46e-55	224.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TLS3_k127_66090_2	1304883.KI912532_gene677	3.383e-20	91.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,2KUUF@206389|Rhodocyclales	206389|Rhodocyclales	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
TLS3_k127_66090_1	748247.AZKH_4201	2.462e-40	156.0	COG1871@1|root,COG1871@2|Bacteria,1RI55@1224|Proteobacteria,2VUAC@28216|Betaproteobacteria,2KWWX@206389|Rhodocyclales	206389|Rhodocyclales	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	-	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
TLS3_k127_66090_0	1123368.AUIS01000004_gene208	2.717e-55	200.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB2	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
TLS3_k127_6609856_0	44689.DDB0230098	2.034e-80	273.0	COG0516@1|root,KOG2550@2759|Eukaryota,3XCNZ@554915|Amoebozoa	554915|Amoebozoa	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	-	GO:0003674,GO:0003682,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS3_k127_6609856_1	378806.STAUR_2976	2.366e-43	165.0	COG0625@1|root,COG0625@2|Bacteria,1PFIW@1224|Proteobacteria,434Q3@68525|delta/epsilon subdivisions,2WZ1E@28221|Deltaproteobacteria,2Z140@29|Myxococcales	28221|Deltaproteobacteria	H	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_N_3
TLS3_k127_6609856_2	5888.CAK91470	6.067e-10	65.0	KOG0498@1|root,KOG0498@2759|Eukaryota	2759|Eukaryota	U	voltage-gated potassium channel activity	-	-	-	ko:K21867	-	-	-	-	ko00000,ko02000	1.A.1.4	-	-	Ion_trans,cNMP_binding
TLS3_k127_6612393_1	517418.Ctha_1772	2.256e-54	194.0	COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	GAF,GerE,HATPase_c,HD,HD_5,HisKA,PAS_4,PAS_9
TLS3_k127_6612393_4	671143.DAMO_0616	8.852e-11	65.0	COG3905@1|root,COG3905@2|Bacteria	2|Bacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS3_k127_6612393_3	244581.IM40_08310	8.889e-23	100.0	COG3668@1|root,COG3668@2|Bacteria,1PZJE@1224|Proteobacteria,2UKWS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Addiction module toxin, RelE StbE	spsF	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS3_k127_6612393_0	1120973.AQXL01000121_gene106	8.668e-68	239.0	COG2022@1|root,COG2022@2|Bacteria,1TQZ1@1239|Firmicutes,4HBSI@91061|Bacilli,277YB@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
TLS3_k127_6612393_2	118005.AWNK01000007_gene805	8.903e-31	138.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_9,RsbU_N,SpoIIE
TLS3_k127_661365_0	1123248.KB893370_gene5116	3.729e-83	286.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS3_k127_6630651_1	398767.Glov_1513	1.54e-32	141.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS3_k127_6630651_0	404589.Anae109_2716	1.867e-53	199.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,42R48@68525|delta/epsilon subdivisions,2WMAR@28221|Deltaproteobacteria,2YUR9@29|Myxococcales	28221|Deltaproteobacteria	E	MazG nucleotide pyrophosphohydrolase domain	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS3_k127_6636983_0	1121927.GOHSU_04_00590	6.54e-36	152.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4GBIW@85026|Gordoniaceae	201174|Actinobacteria	KL	SNF2 Helicase protein	helZ	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF3670,Helicase_C,SNF2_N
TLS3_k127_6638109_1	319224.Sputcn32_0546	1.152e-105	351.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,2Q9HD@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM band 7 protein	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
TLS3_k127_6638109_0	318161.Sden_3070	2.417e-112	373.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,2Q8IF@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM band 7 protein	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
TLS3_k127_6638109_2	1313421.JHBV01000021_gene4813	2.113e-57	209.0	COG0604@1|root,COG0604@2|Bacteria,4NPBM@976|Bacteroidetes,1ITI8@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_6642831_4	56780.SYN_02783	1.114e-05	53.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2MQJV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Lytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
TLS3_k127_6642831_0	1340493.JNIF01000003_gene1736	2.686e-122	404.0	COG0016@1|root,COG0016@2|Bacteria,3Y3NJ@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS3_k127_6642831_1	1313304.CALK_0262	8.74e-113	394.0	COG0072@1|root,COG0072@2|Bacteria	2|Bacteria	J	phenylalanine-tRNA ligase activity	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS3_k127_6642831_2	518766.Rmar_1357	1.208e-24	119.0	COG1680@1|root,COG1680@2|Bacteria,4NJ0F@976|Bacteroidetes	976|Bacteroidetes	V	Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_6642831_3	1270193.JARP01000001_gene2253	9.533e-21	97.0	COG2823@1|root,COG2823@2|Bacteria,4NJ6H@976|Bacteroidetes,1I1QP@117743|Flavobacteriia,2NW7P@237|Flavobacterium	976|Bacteroidetes	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
TLS3_k127_6660326_0	156889.Mmc1_0444	3.971e-43	168.0	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria	1224|Proteobacteria	O	DSBA oxidoreductase	MA20_20720	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
TLS3_k127_6660326_1	518766.Rmar_0205	8.692e-37	145.0	COG1235@1|root,COG1235@2|Bacteria,4NDWB@976|Bacteroidetes,1FJ31@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Metallo-beta-lactamase superfamily	lipB	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
TLS3_k127_6661717_1	1348908.KI518582_gene2395	1.265e-78	268.0	COG0584@1|root,COG0584@2|Bacteria,1VQSU@1239|Firmicutes	1239|Firmicutes	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6661717_0	1196322.A370_05530	5.403e-93	311.0	COG0463@1|root,COG0463@2|Bacteria,1VGSV@1239|Firmicutes	1239|Firmicutes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_6661717_2	1121875.KB907551_gene1098	1.729e-76	265.0	COG1208@1|root,COG1208@2|Bacteria,4PM3W@976|Bacteroidetes,1HYFV@117743|Flavobacteriia	976|Bacteroidetes	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
TLS3_k127_6661717_3	866895.HBHAL_1982	1.835e-08	55.0	COG1208@1|root,COG1208@2|Bacteria,1UKM9@1239|Firmicutes	1239|Firmicutes	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
TLS3_k127_666729_0	545694.TREPR_1617	1.983e-55	205.0	COG0210@1|root,COG0210@2|Bacteria,2J5T4@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_6677111_0	889378.Spiaf_2080	3.117e-91	322.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
TLS3_k127_6677111_2	1112274.KI911560_gene2422	3.19e-29	128.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2VIS1@28216|Betaproteobacteria,2KKEM@206350|Nitrosomonadales	206350|Nitrosomonadales	E	PFAM Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS3_k127_6677111_1	391587.KAOT1_20452	1.007e-33	134.0	COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia	976|Bacteroidetes	M	Peptidase, M23	mepM_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_6685101_0	1385519.N801_17375	0.0007626	51.0	COG2132@1|root,COG2132@2|Bacteria,2ICI4@201174|Actinobacteria,4FIU6@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
TLS3_k127_6706576_0	880071.Fleli_2805	9.682e-28	126.0	COG4872@1|root,COG4872@2|Bacteria,4NIK7@976|Bacteroidetes	976|Bacteroidetes	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
TLS3_k127_6708386_1	1123070.KB899248_gene166	1.282e-24	114.0	COG0744@1|root,COG0744@2|Bacteria,46U6K@74201|Verrucomicrobia,2ITYQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
TLS3_k127_6708386_0	640132.Srot_1211	4.229e-58	215.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.5.2,1.3.98.1	ko:K00226,ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS3_k127_6711268_0	887062.HGR_01607	4.135e-188	603.0	COG1196@1|root,COG2114@1|root,COG2770@1|root,COG1196@2|Bacteria,COG2114@2|Bacteria,COG2770@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4ABWU@80864|Comamonadaceae	28216|Betaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_6711268_1	1036674.A28LD_1539	1.121e-28	120.0	COG2267@1|root,COG2267@2|Bacteria,1MZG8@1224|Proteobacteria,1RMW1@1236|Gammaproteobacteria,2QGIN@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_6712125_0	1121406.JAEX01000001_gene368	8.114e-26	111.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2M93E@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_671227_0	1122921.KB898190_gene1609	1.627e-24	117.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HH84@91061|Bacilli,26SGY@186822|Paenibacillaceae	91061|Bacilli	M	Hydrolase	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
TLS3_k127_671227_1	743722.Sph21_4259	8.197e-21	98.0	COG5002@1|root,COG5002@2|Bacteria,4NDTV@976|Bacteroidetes,1IPRG@117747|Sphingobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	covS	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,PAS
TLS3_k127_6712288_1	1480694.DC28_02695	2.867e-14	76.0	2EY48@1|root,33UVP@2|Bacteria,2J5KT@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein FlaA	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
TLS3_k127_6712288_0	889378.Spiaf_0817	3.156e-20	101.0	2EY48@1|root,3426E@2|Bacteria,2JBFK@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein Flaa	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
TLS3_k127_6712288_2	290397.Adeh_0687	1.673e-10	72.0	COG3031@1|root,COG3031@2|Bacteria,1PUWN@1224|Proteobacteria,42T73@68525|delta/epsilon subdivisions,2WR4E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
TLS3_k127_6715645_0	1242864.D187_005836	1.312e-30	128.0	COG0664@1|root,COG0664@2|Bacteria,1NHNS@1224|Proteobacteria,42X3Y@68525|delta/epsilon subdivisions,2WT4M@28221|Deltaproteobacteria,2YVRK@29|Myxococcales	28221|Deltaproteobacteria	K	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
TLS3_k127_6715662_0	414684.RC1_0665	1.21e-05	57.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2JQH9@204441|Rhodospirillales	204441|Rhodospirillales	H	TonB-dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
TLS3_k127_673322_0	3659.XP_004156084.1	2.031e-19	91.0	COG1234@1|root,2QTNW@2759|Eukaryota,37NC2@33090|Viridiplantae,3GC4W@35493|Streptophyta,4JFYQ@91835|fabids	35493|Streptophyta	S	Ribonuclease z	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
TLS3_k127_6741110_1	1250006.JHZZ01000001_gene1869	8.823e-22	96.0	COG0596@1|root,COG0596@2|Bacteria,4PMBK@976|Bacteroidetes,1IJQW@117743|Flavobacteriia,3VVN2@52959|Polaribacter	976|Bacteroidetes	S	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS3_k127_6741110_0	56110.Oscil6304_2624	2.157e-33	132.0	2DP2P@1|root,3309S@2|Bacteria,1GAAE@1117|Cyanobacteria,1HGD8@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6741110_2	1304885.AUEY01000003_gene446	7.836e-11	68.0	COG3449@1|root,COG3449@2|Bacteria,1N79X@1224|Proteobacteria,4327S@68525|delta/epsilon subdivisions,2WY6F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
TLS3_k127_6746499_1	1405498.SSIM_08925	3.963e-11	70.0	COG0861@1|root,COG0861@2|Bacteria,1TQ09@1239|Firmicutes,4HB99@91061|Bacilli,4GXB3@90964|Staphylococcaceae	91061|Bacilli	P	COG0861 Membrane protein TerC, possibly involved in tellurium resistance	ykoY	-	-	-	-	-	-	-	-	-	-	-	TerC
TLS3_k127_6746499_0	59538.XP_005965855.1	2.182e-14	76.0	COG0012@1|root,KOG1491@2759|Eukaryota,38BC0@33154|Opisthokonta,3BCMG@33208|Metazoa,3CRGD@33213|Bilateria,483BI@7711|Chordata,48VTE@7742|Vertebrata,3JBID@40674|Mammalia,4J1NG@91561|Cetartiodactyla	33208|Metazoa	J	Obg-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS3_k127_6751000_0	1123400.KB904766_gene2957	3.826e-58	223.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,45ZZJ@72273|Thiotrichales	72273|Thiotrichales	L	Helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
TLS3_k127_6752476_0	235909.GK0282	1.517e-155	505.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,4HBAZ@91061|Bacilli,1WEDB@129337|Geobacillus	91061|Bacilli	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS3_k127_6752476_1	862908.BMS_0446	5.211e-107	361.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2MT5M@213481|Bdellovibrionales,2WJE1@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS3_k127_6752476_2	1038867.AXAY01000001_gene6507	5.416e-100	343.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,3JTZ5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	MA20_07375	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
TLS3_k127_6755998_2	1385511.N783_08445	5.319e-36	158.0	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli,2Y8TZ@289201|Pontibacillus	91061|Bacilli	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_6755998_1	195250.CM001776_gene2144	4.351e-66	253.0	COG4974@1|root,COG4974@2|Bacteria,1G4JW@1117|Cyanobacteria,1GZF3@1129|Synechococcus	1117|Cyanobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS3_k127_6755998_0	1340493.JNIF01000003_gene2060	1.436e-130	450.0	COG0358@1|root,COG0358@2|Bacteria	2|Bacteria	L	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,Toprim_N,zf-CHC2
TLS3_k127_6755998_3	55207.KP22_21305	2.353e-25	109.0	COG1396@1|root,COG1396@2|Bacteria,1QV8N@1224|Proteobacteria	1224|Proteobacteria	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS3_k127_6755998_4	1042376.AFPK01000043_gene993	1.116e-08	63.0	2DZN5@1|root,32VEB@2|Bacteria,4NUM5@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6771097_0	1380384.JADN01000007_gene1574	1.352e-32	136.0	28HMY@1|root,2Z7WC@2|Bacteria,4NG8W@976|Bacteroidetes,1HY09@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6772239_2	324602.Caur_1775	0.0002773	49.0	COG1716@1|root,COG1716@2|Bacteria,2G9KV@200795|Chloroflexi,376M0@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Peptidase_C11
TLS3_k127_6772239_0	1353529.M899_2891	8.467e-45	172.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
TLS3_k127_6772239_1	1353529.M899_2890	2.762e-18	89.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2MTFR@213481|Bdellovibrionales,2WITK@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS3_k127_6772863_1	391625.PPSIR1_02476	1.588e-44	169.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1R8QH@1224|Proteobacteria,42T02@68525|delta/epsilon subdivisions,2WPNU@28221|Deltaproteobacteria,2YUP3@29|Myxococcales	28221|Deltaproteobacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
TLS3_k127_6772863_0	742725.HMPREF9450_01699	7.648e-244	760.0	COG0488@1|root,COG0488@2|Bacteria,4NES5@976|Bacteroidetes,2FNIS@200643|Bacteroidia,22UPF@171550|Rikenellaceae	976|Bacteroidetes	S	ATP-binding cassette protein, ChvD family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_6783156_0	1267535.KB906767_gene5090	1.267e-47	180.0	COG1277@1|root,COG1277@2|Bacteria,3Y6D0@57723|Acidobacteria	57723|Acidobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
TLS3_k127_6792139_0	1005994.GTGU_02682	1.188e-37	163.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS3_k127_6792139_1	1034347.CAHJ01000081_gene1395	0.0007364	48.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,4HATQ@91061|Bacilli,1ZM1E@1386|Bacillus	91061|Bacilli	L	Helix-hairpin-helix containing domain	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,UvrD_C_2
TLS3_k127_679249_5	1296415.JACC01000002_gene3274	9.221e-21	103.0	2C0TD@1|root,33M92@2|Bacteria,4NZ5C@976|Bacteroidetes,1IAYJ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_679249_2	643867.Ftrac_2121	4.812e-62	221.0	COG2608@1|root,COG2608@2|Bacteria,4NEDS@976|Bacteroidetes,47TEW@768503|Cytophagia	976|Bacteroidetes	P	MerT mercuric transport protein	-	-	-	-	-	-	-	-	-	-	-	-	HMA,MerT
TLS3_k127_679249_4	743722.Sph21_0220	1.826e-27	113.0	COG0053@1|root,COG0053@2|Bacteria,4NVGY@976|Bacteroidetes,1ITV5@117747|Sphingobacteriia	976|Bacteroidetes	P	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	MerC
TLS3_k127_679249_6	489825.LYNGBM3L_46010	3.323e-20	93.0	2E72B@1|root,331KY@2|Bacteria,1G96A@1117|Cyanobacteria,1HCV2@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_679249_1	1313301.AUGC01000011_gene1144	1.64e-63	227.0	COG0452@1|root,COG0452@2|Bacteria,4NE46@976|Bacteroidetes	976|Bacteroidetes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS3_k127_679249_0	1201293.AKXQ01000009_gene939	4.183e-79	273.0	COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,1RSIB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_679249_3	1356852.N008_01765	2.545e-31	137.0	COG2357@1|root,COG2357@2|Bacteria,4NFMF@976|Bacteroidetes,47P2Z@768503|Cytophagia	976|Bacteroidetes	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM
TLS3_k127_6793949_1	1298593.TOL_3647	1.149e-38	148.0	COG2267@1|root,COG2267@2|Bacteria,1QYEP@1224|Proteobacteria,1T3P8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_6793949_0	1191523.MROS_0845	1.313e-121	396.0	COG0045@1|root,COG0045@2|Bacteria	2|Bacteria	C	succinate-CoA ligase activity	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS3_k127_6799608_0	1158292.JPOE01000005_gene904	7.673e-07	59.0	COG2706@1|root,COG3391@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,1RB38@1224|Proteobacteria,2VSAM@28216|Betaproteobacteria,1KNMC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_6803218_0	215803.DB30_5750	4.375e-61	229.0	COG4258@1|root,COG4258@2|Bacteria,1QX7Z@1224|Proteobacteria,43C13@68525|delta/epsilon subdivisions,2X7BR@28221|Deltaproteobacteria,2YU55@29|Myxococcales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
TLS3_k127_6803218_1	1121877.JQKF01000001_gene1351	4.006e-10	61.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4CNIU@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_6804880_0	1216932.CM240_3080	8.848e-45	171.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36EH8@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_6806409_1	1227739.Hsw_3195	6.8e-12	76.0	COG1520@1|root,COG1520@2|Bacteria,4PNH1@976|Bacteroidetes	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
TLS3_k127_6821538_0	926692.AZYG01000007_gene1301	1.163e-108	364.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,3WAGF@53433|Halanaerobiales	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TLS3_k127_682412_0	1173023.KE650771_gene5328	1.079e-99	329.0	COG1136@1|root,COG1136@2|Bacteria,1G4IP@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_682412_1	1304877.KI519399_gene3042	1.261e-22	102.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,3JVPM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_6834583_3	67593.Physo143949	5.907e-16	86.0	COG0515@1|root,COG0666@1|root,KOG0192@2759|Eukaryota,KOG0504@2759|Eukaryota,3QDVJ@4776|Peronosporales	4776|Peronosporales	T	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Pkinase_Tyr
TLS3_k127_6834583_4	1408439.JHXW01000002_gene479	7.287e-08	60.0	2ESSS@1|root,33KB5@2|Bacteria,37CS9@32066|Fusobacteria	32066|Fusobacteria	S	Protein of unknown function (DUF2628)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2628
TLS3_k127_6834583_2	1123279.ATUS01000001_gene2006	9.425e-39	155.0	COG3687@1|root,COG3687@2|Bacteria,1RG1N@1224|Proteobacteria,1S5SB@1236|Gammaproteobacteria,1J9V9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
TLS3_k127_6834583_0	345341.KUTG_04234	6.246e-157	499.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
TLS3_k127_6834583_1	498211.CJA_3745	7.687e-84	281.0	COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,1RNBQ@1236|Gammaproteobacteria,1FI4Z@10|Cellvibrio	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_6835667_0	5911.EAS05931	1.968e-97	333.0	COG0213@1|root,2QPRY@2759|Eukaryota,3ZCW3@5878|Ciliophora	5878|Ciliophora	H	Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS3_k127_686093_0	207559.Dde_2166	1.172e-136	441.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2M9WJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS3_k127_686093_1	1423321.AS29_17305	4.445e-32	141.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,1ZBF3@1386|Bacillus	91061|Bacilli	S	protein conserved in bacteria	ybbC	-	-	-	-	-	-	-	-	-	-	-	DUF1343
TLS3_k127_686093_2	487796.Flav2ADRAFT_1370	1.079e-30	126.0	COG0026@1|root,COG0026@2|Bacteria,4NEGE@976|Bacteroidetes,1HXZB@117743|Flavobacteriia	976|Bacteroidetes	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS3_k127_686093_3	1122605.KB893637_gene3088	2.091e-09	60.0	COG0026@1|root,COG0026@2|Bacteria,4NEGE@976|Bacteroidetes,1IQSA@117747|Sphingobacteriia	976|Bacteroidetes	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS3_k127_6861552_0	768671.ThimaDRAFT_1313	1.232e-27	116.0	COG1487@1|root,COG1487@2|Bacteria,1RHQJ@1224|Proteobacteria,1TKC4@1236|Gammaproteobacteria,1X1S9@135613|Chromatiales	135613|Chromatiales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_6861552_1	439235.Dalk_0811	6.581e-22	100.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,1Q9TA@1224|Proteobacteria,42QB0@68525|delta/epsilon subdivisions,2WMJT@28221|Deltaproteobacteria,2MN1A@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6862601_0	889378.Spiaf_1449	1.012e-79	283.0	COG0457@1|root,COG0457@2|Bacteria,2J5PC@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
TLS3_k127_686517_0	1162668.LFE_0291	3.705e-75	265.0	COG0643@1|root,COG0643@2|Bacteria,3J0BG@40117|Nitrospirae	40117|Nitrospirae	NT	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
TLS3_k127_6869495_0	665952.HMPREF1015_00607	1.325e-145	471.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,1ZARG@1386|Bacillus	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS3_k127_6875783_1	570967.JMLV01000002_gene1584	4.324e-141	465.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2TRTV@28211|Alphaproteobacteria,2JRRJ@204441|Rhodospirillales	204441|Rhodospirillales	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS3_k127_6875783_3	1166018.FAES_0671	1.595e-09	63.0	COG4251@1|root,COG4251@2|Bacteria,4NTN4@976|Bacteroidetes,47RN1@768503|Cytophagia	976|Bacteroidetes	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
TLS3_k127_6875783_0	1403819.BATR01000008_gene241	2.887e-197	636.0	COG3852@1|root,COG5000@1|root,COG3852@2|Bacteria,COG5000@2|Bacteria,46Z98@74201|Verrucomicrobia,2IWR1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
TLS3_k127_6875783_2	269799.Gmet_2308	2.871e-22	102.0	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,42ZZE@68525|delta/epsilon subdivisions,2WV71@28221|Deltaproteobacteria,43UZ2@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	cheY40H-2	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
TLS3_k127_6878177_1	585501.HMPREF6123_0743	6.821e-18	92.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,2PS7Z@265975|Oribacterium	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS3_k127_6878177_0	1173028.ANKO01000017_gene82	1.941e-88	302.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G4ED@1117|Cyanobacteria,1HA0Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,Guanylate_cyc
TLS3_k127_6890509_0	1317118.ATO8_13867	6.087e-35	137.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,4KKZV@93682|Roseivivax	28211|Alphaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS3_k127_6890887_0	760192.Halhy_5766	2.271e-15	88.0	COG2207@1|root,COG2207@2|Bacteria,4NRDN@976|Bacteroidetes,1J05V@117747|Sphingobacteriia	976|Bacteroidetes	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_6890887_1	1144275.COCOR_07801	1.41e-12	72.0	COG1994@1|root,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,42WVB@68525|delta/epsilon subdivisions,2WT41@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6891421_5	246197.MXAN_1536	0.0002962	43.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,431ED@68525|delta/epsilon subdivisions,2WWZ0@28221|Deltaproteobacteria,2YVD5@29|Myxococcales	28221|Deltaproteobacteria	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
TLS3_k127_6891421_3	278957.ABEA03000160_gene41	8.055e-09	63.0	2BWTE@1|root,330HW@2|Bacteria,46XUB@74201|Verrucomicrobia,3K86Z@414999|Opitutae	414999|Opitutae	S	Protein of unknown function (DUF2937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2937
TLS3_k127_6891421_2	1173029.JH980292_gene1978	1.72e-64	239.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
TLS3_k127_6891421_0	635013.TherJR_1368	2.7e-167	544.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,260WS@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS3_k127_6891421_4	760568.Desku_3413	1.182e-07	59.0	COG2402@1|root,COG2402@2|Bacteria,1V8M3@1239|Firmicutes,24MAG@186801|Clostridia	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_6891421_1	589865.DaAHT2_1209	4.322e-67	234.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales	28221|Deltaproteobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS3_k127_6893414_0	926692.AZYG01000040_gene1542	6.683e-26	118.0	COG2121@1|root,COG2121@2|Bacteria,1V6M7@1239|Firmicutes,24KY0@186801|Clostridia,3WAQ4@53433|Halanaerobiales	186801|Clostridia	S	protein conserved in bacteria	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
TLS3_k127_6893414_1	1307761.L21SP2_0140	3.688e-14	81.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_6899329_0	522772.Dacet_2297	9.273e-50	184.0	COG0040@1|root,COG0040@2|Bacteria,2GFEF@200930|Deferribacteres	200930|Deferribacteres	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
TLS3_k127_6908242_2	926569.ANT_02640	2.6e-17	86.0	COG0573@1|root,COG0573@2|Bacteria,2G62J@200795|Chloroflexi	200795|Chloroflexi	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS3_k127_6908242_1	926569.ANT_02630	5.307e-65	233.0	COG0226@1|root,COG0226@2|Bacteria,2G7T2@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS3_k127_6908242_3	880073.Calab_1859	9.817e-14	75.0	COG0640@1|root,COG0640@2|Bacteria,2NQ1G@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS3_k127_6908242_0	1121939.L861_00255	1.892e-84	293.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,1XHXD@135619|Oceanospirillales	135619|Oceanospirillales	E	M18 family aminopeptidase	-	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
TLS3_k127_6911794_2	290633.GOX2253	4.072e-48	185.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,2JPSX@204441|Rhodospirillales	204441|Rhodospirillales	M	NmrA-like family	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
TLS3_k127_6911794_0	1232683.ADIMK_3165	1.677e-107	368.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465EN@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_6911794_1	349521.HCH_00157	4.829e-73	263.0	COG2355@1|root,COG4733@1|root,COG2355@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	F5_F8_type_C,Peptidase_M19
TLS3_k127_6911794_3	114615.BRADO0013	3.26e-37	156.0	COG2207@1|root,COG2207@2|Bacteria,1P4M5@1224|Proteobacteria,2TSQV@28211|Alphaproteobacteria,3JU83@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_69177_0	706587.Desti_4613	2.653e-05	56.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria	1224|Proteobacteria	KT	ankyrin repeat	-	-	-	ko:K06867,ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
TLS3_k127_693283_2	1122604.JONR01000006_gene2705	7.51e-12	70.0	COG0596@1|root,COG0596@2|Bacteria,1QVQ5@1224|Proteobacteria,1T2GP@1236|Gammaproteobacteria,1XDEN@135614|Xanthomonadales	135614|Xanthomonadales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_693283_3	1232410.KI421412_gene348	1.164e-10	64.0	COG1141@1|root,COG1141@2|Bacteria,1Q2EF@1224|Proteobacteria,42VI5@68525|delta/epsilon subdivisions,2WS6Z@28221|Deltaproteobacteria,43SRS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Divergent 4Fe-4S mono-cluster	frx-4	-	-	ko:K05337	-	-	-	-	ko00000	-	-	iAF987.Gmet_0148	Fer4_13
TLS3_k127_693283_0	91464.S7335_4950	9.741e-35	149.0	COG0204@1|root,COG0204@2|Bacteria,1G3F1@1117|Cyanobacteria,1H47Q@1129|Synechococcus	1117|Cyanobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS3_k127_6932896_0	195250.CM001776_gene91	1.5e-36	150.0	COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria,1GYV6@1129|Synechococcus	1117|Cyanobacteria	V	ABC-type antimicrobial peptide transport system, permease component	devC	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_6932896_1	1173024.KI912154_gene1131	9.206e-13	75.0	COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria,1JK50@1189|Stigonemataceae	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
TLS3_k127_6933535_0	522772.Dacet_1887	9.848e-109	362.0	COG0014@1|root,COG0014@2|Bacteria,2GEXR@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_6941052_2	1379698.RBG1_1C00001G0687	2.651e-49	185.0	COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_6941052_3	273068.TTE1310	3.26e-16	86.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,42GHZ@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05505	NUDIX
TLS3_k127_6941052_0	443143.GM18_0007	1.225e-101	341.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,43TUN@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS3_k127_6941052_1	1313421.JHBV01000041_gene3480	9.086e-57	203.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,1ITE6@117747|Sphingobacteriia	976|Bacteroidetes	O	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS3_k127_6943829_1	888062.HMPREF9083_0716	4.604e-18	91.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4H4HE@909932|Negativicutes	909932|Negativicutes	M	Peptidase, M23 family	envC_2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_6943829_0	697303.Thewi_0927	2.234e-18	89.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,42GQS@68295|Thermoanaerobacterales	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_6944161_0	1033738.CAEP01000020_gene3623	3.643e-122	399.0	COG1118@1|root,COG1118@2|Bacteria,1UI6I@1239|Firmicutes,4ISFJ@91061|Bacilli,26EU7@186818|Planococcaceae	91061|Bacilli	P	TOBE-like domain	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
TLS3_k127_6944161_1	56780.SYN_01481	4.333e-77	285.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MQZ2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
TLS3_k127_6947946_1	1166018.FAES_1238	1.717e-18	89.0	COG4191@1|root,COG4191@2|Bacteria,4NSNP@976|Bacteroidetes,47R37@768503|Cytophagia	976|Bacteroidetes	T	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
TLS3_k127_6947946_0	937774.TEQUI_1180	1.333e-31	132.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,3T3X7@506|Alcaligenaceae	28216|Betaproteobacteria	S	Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS3_k127_6947946_2	909663.KI867150_gene1307	2.132e-09	65.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,2MQDX@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
TLS3_k127_6951596_1	1391647.AVSV01000026_gene476	3.757e-31	131.0	COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,36FHM@31979|Clostridiaceae	186801|Clostridia	N	PFAM OmpA MotB domain protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS3_k127_6951596_0	485917.Phep_0160	6.274e-141	452.0	COG0114@1|root,COG0114@2|Bacteria,4NEQP@976|Bacteroidetes,1IUVX@117747|Sphingobacteriia	976|Bacteroidetes	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS3_k127_6952550_1	1121930.AQXG01000006_gene871	6.627e-34	134.0	COG1127@1|root,COG1127@2|Bacteria,4NETG@976|Bacteroidetes,1IP0Y@117747|Sphingobacteriia	976|Bacteroidetes	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS3_k127_6952550_0	589865.DaAHT2_1300	2.462e-60	214.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MJIH@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS3_k127_6972649_2	1379270.AUXF01000005_gene501	4.217e-05	53.0	COG2834@1|root,COG2834@2|Bacteria,1ZTXG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
TLS3_k127_6972649_1	1123274.KB899410_gene3540	2.202e-21	107.0	COG1426@1|root,COG1426@2|Bacteria,2J61E@203691|Spirochaetes	203691|Spirochaetes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
TLS3_k127_6972649_0	290397.Adeh_0093	8.383e-61	223.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2YUDC@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
TLS3_k127_697483_0	1353276.JADR01000008_gene988	5.495e-24	108.0	2E95M@1|root,333EB@2|Bacteria,4PFU4@976|Bacteroidetes,1I8P0@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6979029_0	177437.HRM2_26840	4.443e-210	665.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
TLS3_k127_6979029_1	1206732.BAGD01000276_gene6218	1.194e-16	85.0	COG2050@1|root,COG2050@2|Bacteria,2IJ8E@201174|Actinobacteria,4G1ZR@85025|Nocardiaceae	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_6979029_2	43228.XP_007738166.1	6.664e-05	48.0	2E2QM@1|root,2S9XI@2759|Eukaryota,3A75K@33154|Opisthokonta,3P5A9@4751|Fungi,3R45Q@4890|Ascomycota,20FSW@147545|Eurotiomycetes	4751|Fungi	S	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS3_k127_6981483_0	580332.Slit_2209	5.502e-62	224.0	COG0679@1|root,COG0679@2|Bacteria,1PHSS@1224|Proteobacteria,2VSSE@28216|Betaproteobacteria,44V9Y@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TLS3_k127_6981774_4	290397.Adeh_0802	2.728e-15	78.0	COG1999@1|root,COG1999@2|Bacteria,1R9EM@1224|Proteobacteria,42N5F@68525|delta/epsilon subdivisions,2WKG7@28221|Deltaproteobacteria,2YV22@29|Myxococcales	28221|Deltaproteobacteria	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	sco	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	-
TLS3_k127_6981774_2	880073.Calab_0304	1.66e-57	214.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2NNSH@2323|unclassified Bacteria	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
TLS3_k127_6981774_0	756272.Plabr_4674	5.188e-202	642.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS3_k127_6981774_3	290397.Adeh_0805	1.622e-39	157.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,42VFA@68525|delta/epsilon subdivisions,2X6H6@28221|Deltaproteobacteria,2YV57@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS3_k127_6981774_5	1192034.CAP_2034	1.412e-08	60.0	2DR0H@1|root,339NS@2|Bacteria,1R3N7@1224|Proteobacteria,42X1P@68525|delta/epsilon subdivisions,2X8S7@28221|Deltaproteobacteria,2Z3NK@29|Myxococcales	28221|Deltaproteobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
TLS3_k127_6981774_1	796942.HMPREF9623_00232	3.429e-88	304.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TLS3_k127_6988963_0	335543.Sfum_1411	3.98e-80	279.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2MQ6I@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
TLS3_k127_7005933_0	7897.ENSLACP00000000033	1.653e-27	114.0	KOG4605@1|root,KOG4605@2759|Eukaryota,3A8Z4@33154|Opisthokonta,3CNFC@33208|Metazoa,3E4K8@33213|Bilateria,48EIW@7711|Chordata,49BIH@7742|Vertebrata	33208|Metazoa	S	CDGSH-type zinc finger. Function unknown.	CISD3	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
TLS3_k127_7005933_1	744980.TRICHSKD4_4293	7.354e-15	83.0	COG2114@1|root,COG2343@1|root,COG2114@2|Bacteria,COG2343@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,NTP_transf_9
TLS3_k127_7009776_2	85982.XP_007321494.1	9.902e-12	69.0	COG1648@1|root,2RYIW@2759|Eukaryota,39KEU@33154|Opisthokonta,3NYT8@4751|Fungi,3V102@5204|Basidiomycota,224V0@155619|Agaricomycetes	4751|Fungi	H	Siroheme synthase	MET8	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016741,GO:0016829,GO:0018130,GO:0019354,GO:0019438,GO:0019752,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042084,GO:0042168,GO:0042440,GO:0043115,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046156,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_C,Sirohm_synth_M
TLS3_k127_7009776_0	1236541.BALL01000003_gene500	2.405e-136	452.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,2Q8T5@267890|Shewanellaceae	1236|Gammaproteobacteria	H	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_3037,iECH74115_1262.ECH74115_4017,iECIAI1_1343.ECIAI1_2867,iECNA114_1301.ECNA114_2794,iECO103_1326.ECO103_3307,iECSE_1348.ECSE_3019,iECSF_1327.ECSF_2552,iECSP_1301.ECSP_3712,iECUMN_1333.ECUMN_3091,iECW_1372.ECW_m2971,iECs_1301.ECs3618,iEKO11_1354.EKO11_1005,iEcE24377_1341.EcE24377A_3065,iSFV_1184.SFV_2742,iSbBS512_1146.SbBS512_E3112,iWFL_1372.ECW_m2971,iZ_1308.Z4073	NIR_SIR,NIR_SIR_ferr
TLS3_k127_7009776_1	1499967.BAYZ01000026_gene1596	3.155e-48	185.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,TPR_12
TLS3_k127_7026097_1	1353276.JADR01000009_gene1800	1.715e-09	70.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia	976|Bacteroidetes	K	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
TLS3_k127_7026097_0	1158345.JNLL01000001_gene318	6.656e-96	322.0	COG1220@1|root,COG1220@2|Bacteria,2G3TH@200783|Aquificae	200783|Aquificae	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
TLS3_k127_7026114_0	1280390.CBQR020000166_gene4414	2.651e-22	113.0	COG5297@1|root,COG5297@2|Bacteria,1V1T2@1239|Firmicutes,4HUDU@91061|Bacilli,26S1Z@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase family 6	guxA	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	CBM_3,Glyco_hydro_6,fn3
TLS3_k127_7026114_1	641107.CDLVIII_4176	2.574e-10	64.0	COG2267@1|root,COG2267@2|Bacteria,1TPI0@1239|Firmicutes,247QR@186801|Clostridia,36F4I@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	1.11.1.10,3.1.1.24	ko:K00433,ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS3_k127_7043990_1	749222.Nitsa_1539	8.717e-14	80.0	COG0457@1|root,COG0457@2|Bacteria,1NWHJ@1224|Proteobacteria,42SQH@68525|delta/epsilon subdivisions,2YQCJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
TLS3_k127_7043990_0	518766.Rmar_0090	5.564e-28	116.0	COG1842@1|root,COG1842@2|Bacteria,4P0T5@976|Bacteroidetes,1FIR5@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
TLS3_k127_7047746_0	1347342.BN863_11390	1.976e-06	58.0	COG1345@1|root,COG3291@1|root,COG3405@1|root,COG1345@2|Bacteria,COG3291@2|Bacteria,COG3405@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia	976|Bacteroidetes	DZ	adhesin AidA-related	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Gly_rich,HYR,Laminin_G_3,PKD,SprB
TLS3_k127_7051028_0	59196.RICGR_1150	2.518e-88	301.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1JDYG@118969|Legionellales	118969|Legionellales	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS3_k127_7068151_6	368408.Tpen_0015	2.006e-14	78.0	arCOG02998@1|root,arCOG02998@2157|Archaea	2157|Archaea	L	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_7068151_3	448385.sce9226	5.546e-49	184.0	COG5031@1|root,COG5031@2|Bacteria,1NKS8@1224|Proteobacteria,434J5@68525|delta/epsilon subdivisions,2WYWC@28221|Deltaproteobacteria,2Z0SR@29|Myxococcales	28221|Deltaproteobacteria	H	ubiquinone biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7068151_2	644282.Deba_1109	1.587e-84	291.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42S0M@68525|delta/epsilon subdivisions,2WNYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	yheT	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_7068151_4	1313421.JHBV01000029_gene2002	3.346e-44	175.0	COG3386@1|root,COG3386@2|Bacteria,4NNEW@976|Bacteroidetes	976|Bacteroidetes	G	Arylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Arylesterase
TLS3_k127_7068151_7	1217703.F904_03084	8.015e-10	68.0	COG2239@1|root,COG2239@2|Bacteria,1RCPU@1224|Proteobacteria,1S1ZV@1236|Gammaproteobacteria,3NJF9@468|Moraxellaceae	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7068151_0	1158146.KB907125_gene2349	4.749e-191	650.0	COG0642@1|root,COG0683@1|root,COG5002@1|root,COG0683@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1T5W7@1236|Gammaproteobacteria,1X2WG@135613|Chromatiales	135613|Chromatiales	T	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Peripla_BP_6
TLS3_k127_7068151_1	314345.SPV1_05153	1.495e-188	643.0	COG2197@1|root,COG2203@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria	1224|Proteobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg
TLS3_k127_7068151_5	386456.JQKN01000002_gene2436	7.799e-17	91.0	COG3315@1|root,arCOG03588@2157|Archaea	2157|Archaea	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
TLS3_k127_7073042_0	1408422.JHYF01000006_gene1012	1.875e-228	721.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,36DYE@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS3_k127_7073042_1	1149133.ppKF707_3713	3.198e-64	228.0	28MN9@1|root,2ZAXV@2|Bacteria,1PPEY@1224|Proteobacteria,1RYAD@1236|Gammaproteobacteria,1YDYC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7073937_1	4538.ORGLA04G0228400.1	1.884e-05	48.0	COG1304@1|root,KOG0538@2759|Eukaryota,37QEA@33090|Viridiplantae,3GX5S@35493|Streptophyta,3KZ0J@4447|Liliopsida,3I35P@38820|Poales	35493|Streptophyta	C	FMN-dependent dehydrogenase	-	-	1.1.3.15	ko:K11517	ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00630,map01100,map01110,map01120,map01130,map01200,map04146	M00532	R00475	RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
TLS3_k127_7073937_0	357808.RoseRS_3593	2.269e-24	119.0	COG1502@1|root,COG1502@2|Bacteria,2G8RC@200795|Chloroflexi,37519@32061|Chloroflexia	32061|Chloroflexia	I	PFAM phospholipase D Transphosphatidylase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
TLS3_k127_7078544_3	1435356.Y013_11120	6.375e-06	54.0	COG2050@1|root,COG2050@2|Bacteria,2GK27@201174|Actinobacteria,4G9CC@85025|Nocardiaceae	201174|Actinobacteria	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_7078544_0	614083.AWQR01000024_gene2209	6.685e-48	179.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,2VMH0@28216|Betaproteobacteria,4AAMY@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_7078544_2	557598.LHK_00435	8.505e-15	77.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,2VMH0@28216|Betaproteobacteria,2KQZ9@206351|Neisseriales	206351|Neisseriales	EG	ORF located using Glimmer GeneMark Blastx COG0697	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_7078544_1	762903.Pedsa_2784	1.254e-16	90.0	COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,1INKY@117747|Sphingobacteriia	976|Bacteroidetes	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS3_k127_7078544_4	985255.APHJ01000023_gene2668	7.225e-05	51.0	COG3212@1|root,COG3212@2|Bacteria,4NR13@976|Bacteroidetes,1I2ZZ@117743|Flavobacteriia	976|Bacteroidetes	S	Putative beta-lactamase-inhibitor-like, PepSY-like	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_like
TLS3_k127_7081563_2	1289135.A966_09269	2.479e-27	113.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7081563_0	1223521.BBJX01000004_gene2549	2.391e-67	233.0	COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,4ADFN@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase_4
TLS3_k127_7081563_1	633.DJ40_3774	3.134e-44	167.0	COG1988@1|root,COG1988@2|Bacteria,1RBHW@1224|Proteobacteria,1S2F9@1236|Gammaproteobacteria,41HBE@629|Yersinia	1236|Gammaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	ybcI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
TLS3_k127_7081563_3	378806.STAUR_6349	3.512e-07	61.0	COG3014@1|root,COG3014@2|Bacteria,1PD4S@1224|Proteobacteria,42V8Q@68525|delta/epsilon subdivisions,2WRSG@28221|Deltaproteobacteria,2YW0X@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
TLS3_k127_708202_1	1004149.AFOE01000006_gene2013	9.275e-24	103.0	COG1131@1|root,COG1131@2|Bacteria,4NH9G@976|Bacteroidetes,1I135@117743|Flavobacteriia	976|Bacteroidetes	V	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13
TLS3_k127_708202_0	879212.DespoDRAFT_00906	1.791e-271	840.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2MJQY@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
TLS3_k127_7090509_0	889378.Spiaf_1842	3.367e-77	270.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	fprA1	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS3_k127_7090509_1	1444310.JANV01000119_gene330	1.196e-56	208.0	COG0119@1|root,COG0119@2|Bacteria,1TQG3@1239|Firmicutes,4HA1U@91061|Bacilli,1ZC18@1386|Bacillus	91061|Bacilli	E	Hydroxymethylglutaryl-CoA lyase	yngG	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS3_k127_7090509_2	397278.JOJN01000006_gene976	1.287e-39	158.0	COG1024@1|root,COG1024@2|Bacteria,2I7QX@201174|Actinobacteria,4DRJV@85009|Propionibacteriales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS3_k127_7090509_3	488538.SAR116_0360	6.198e-05	49.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria,4BQCT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
TLS3_k127_7090931_0	1384054.N790_01970	1.328e-60	216.0	COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,1S772@1236|Gammaproteobacteria,1X6G4@135614|Xanthomonadales	135614|Xanthomonadales	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS3_k127_7090931_1	929562.Emtol_4079	2.366e-38	146.0	COG1398@1|root,COG1398@2|Bacteria,4NE0I@976|Bacteroidetes,47KJ0@768503|Cytophagia	976|Bacteroidetes	I	fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS3_k127_7091929_0	1538644.KO02_15225	6.419e-06	57.0	COG1680@1|root,COG1680@2|Bacteria,4NK2E@976|Bacteroidetes	976|Bacteroidetes	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,TPR_2
TLS3_k127_7098473_0	644282.Deba_1978	2.581e-126	409.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_2942	tRNA-synt_2e
TLS3_k127_7098473_1	340177.Cag_1205	1.182e-07	65.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1FEC7@1090|Chlorobi	1090|Chlorobi	P	sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS3_k127_7098651_0	1379698.RBG1_1C00001G1131	1.149e-99	346.0	COG0497@1|root,COG0497@2|Bacteria,2NNUS@2323|unclassified Bacteria	2|Bacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631,ko:K07459,ko:K20345	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000,ko03400	3.A.1.112,8.A.1	-	-	SMC_N,YkyA
TLS3_k127_7098651_1	518766.Rmar_2430	8.697e-72	251.0	COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes	976|Bacteroidetes	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS3_k127_7103542_0	1265505.ATUG01000001_gene4101	5.048e-52	213.0	COG3209@1|root,COG3266@1|root,COG3209@2|Bacteria,COG3266@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TLS3_k127_7105211_0	1125701.HMPREF1221_00416	2.84e-119	392.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS3_k127_7105211_1	1313301.AUGC01000014_gene2500	1.752e-20	103.0	COG2208@1|root,COG2208@2|Bacteria,4NKKK@976|Bacteroidetes	976|Bacteroidetes	KT	Serine phosphatase RsbU regulator of sigma subunit	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,SpoIIE
TLS3_k127_7109716_0	186497.PF0599	3.005e-63	225.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS3_k127_7110010_0	945713.IALB_0362	1.085e-108	362.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	msbA	-	-	ko:K02021,ko:K06147,ko:K06148,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_7110010_1	906968.Trebr_0195	1.461e-36	143.0	COG1406@1|root,COG1406@2|Bacteria,2JAIP@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
TLS3_k127_7110010_2	1238182.C882_3750	1.604e-36	149.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,2JQ4Y@204441|Rhodospirillales	204441|Rhodospirillales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_7114821_1	153721.MYP_293	1.267e-26	115.0	COG1858@1|root,COG1858@2|Bacteria,4NE4P@976|Bacteroidetes,47K55@768503|Cytophagia	976|Bacteroidetes	C	cytochrome c peroxidase	yhjA	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
TLS3_k127_7114821_0	1254432.SCE1572_16385	1.663e-46	177.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
TLS3_k127_7115020_2	640512.BC1003_2803	8.283e-13	71.0	COG0697@1|root,COG0697@2|Bacteria,1MVKG@1224|Proteobacteria,2VM56@28216|Betaproteobacteria,1K4PV@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	eamA	-	-	ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3.2	-	-	EamA
TLS3_k127_7115020_0	1411685.U062_01015	7.9e-61	231.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4QE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2222,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg
TLS3_k127_7115020_1	1123508.JH636440_gene2102	6.091e-53	193.0	COG3000@1|root,COG3000@2|Bacteria,2J12U@203682|Planctomycetes	203682|Planctomycetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_712022_0	880073.Calab_3009	8.274e-67	244.0	COG2208@1|root,COG2208@2|Bacteria,2NQW9@2323|unclassified Bacteria	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	CHASE2,GAF_2,HATPase_c_2,SpoIIE
TLS3_k127_7126889_2	1122138.AQUZ01000019_gene8171	6.782e-10	65.0	COG1520@1|root,COG4733@1|root,COG1520@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,F5_F8_type_C,PQQ_2,SLH
TLS3_k127_7126889_1	1379698.RBG1_1C00001G1398	3.071e-16	92.0	COG1520@1|root,COG1520@2|Bacteria,2NQ51@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,PQQ_2,SBBP
TLS3_k127_7126889_0	1120977.JHUX01000003_gene1731	4.905e-42	157.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria,3NK46@468|Moraxellaceae	1236|Gammaproteobacteria	S	Appr-1'-p processing enzyme	ymdB	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231	-	-	-	-	-	-	-	-	-	-	Macro
TLS3_k127_712813_0	1121904.ARBP01000001_gene5924	1.403e-14	85.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS3_k127_7130535_0	765869.BDW_04145	4.957e-117	389.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2MSUE@213481|Bdellovibrionales,2WJE6@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_7130535_1	1353529.M899_1584	8.7e-19	97.0	COG2866@1|root,COG2866@2|Bacteria,1N9AY@1224|Proteobacteria,430W9@68525|delta/epsilon subdivisions,2MSZJ@213481|Bdellovibrionales,2WW2T@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	carboxypeptidase	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	AstE_AspA,Peptidase_M14
TLS3_k127_7130535_2	316067.Geob_0889	6.771e-16	88.0	COG3156@1|root,COG3156@2|Bacteria,1N9I4@1224|Proteobacteria,42V0N@68525|delta/epsilon subdivisions,2WRR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM General secretion pathway protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
TLS3_k127_7133298_2	1406840.Q763_01810	3.562e-61	216.0	COG1741@1|root,COG1741@2|Bacteria,4NGJ5@976|Bacteroidetes,1HYY2@117743|Flavobacteriia,2NVEC@237|Flavobacterium	976|Bacteroidetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
TLS3_k127_7133298_0	983917.RGE_09710	7.299e-98	344.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KJCZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
TLS3_k127_7133298_1	425104.Ssed_3347	7.227e-87	291.0	COG1960@1|root,COG1960@2|Bacteria,1R15B@1224|Proteobacteria	1224|Proteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS3_k127_7137062_2	1123057.P872_16335	4.844e-34	133.0	COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,47PUA@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS3_k127_7137062_0	546271.Selsp_1920	1.056e-174	561.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H26S@909932|Negativicutes	909932|Negativicutes	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS3_k127_7137062_1	1207076.ALAT01000099_gene2400	9.786e-52	190.0	COG4229@1|root,COG4229@2|Bacteria,1R3V9@1224|Proteobacteria,1RP5Y@1236|Gammaproteobacteria,1Z2GS@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)	mtnC	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019509,GO:0019752,GO:0042578,GO:0043094,GO:0043102,GO:0043436,GO:0043874,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.77	ko:K09880	ko00270,ko01100,map00270,map01100	M00034	R07395	RC02779	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
TLS3_k127_7138992_1	378806.STAUR_6562	5.332e-27	119.0	COG1226@1|root,COG1226@2|Bacteria,1PEHA@1224|Proteobacteria,43A38@68525|delta/epsilon subdivisions,2X24Q@28221|Deltaproteobacteria,2YW67@29|Myxococcales	28221|Deltaproteobacteria	P	TrkA-C domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	TrkA_C,TrkA_N
TLS3_k127_7138992_0	1161401.ASJA01000016_gene1334	8.909e-64	226.0	COG0662@1|root,COG0662@2|Bacteria,1NX04@1224|Proteobacteria	1224|Proteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_7138992_2	215803.DB30_5159	1.253e-25	108.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2YUPX@29|Myxococcales	28221|Deltaproteobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS3_k127_71423_3	1068980.ARVW01000001_gene4180	1.508e-16	81.0	COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,4DYKR@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_71423_1	589865.DaAHT2_1884	4.283e-46	181.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
TLS3_k127_71423_2	1321781.HMPREF1985_01468	2.357e-18	91.0	COG0239@1|root,COG0239@2|Bacteria	2|Bacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS3_k127_71423_0	1519464.HY22_10540	1.348e-120	398.0	COG0029@1|root,COG0029@2|Bacteria,1FD79@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS3_k127_7150404_0	468059.AUHA01000005_gene2577	4.385e-115	373.0	COG2057@1|root,COG2057@2|Bacteria,4NG9J@976|Bacteroidetes,1IQBC@117747|Sphingobacteriia	976|Bacteroidetes	I	PFAM Coenzyme A transferase	scoB	-	2.8.3.5,2.8.3.6	ko:K01029,ko:K01032	ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120	-	R00410,R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS3_k127_7150404_1	929556.Solca_2021	9.426e-99	324.0	COG1788@1|root,COG1788@2|Bacteria,4NF3T@976|Bacteroidetes,1IQP0@117747|Sphingobacteriia	976|Bacteroidetes	I	PFAM Coenzyme A transferase	scoA	-	2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9	ko:K01027,ko:K01028,ko:K01031,ko:K01034	ko00072,ko00280,ko00310,ko00362,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00362,map00627,map00640,map00650,map01100,map01120,map02020	-	R00410,R01179,R01359,R01365,R02990,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS3_k127_7151687_3	1397528.Q671_15010	7.266e-15	88.0	COG0398@1|root,COG0398@2|Bacteria,1QV55@1224|Proteobacteria,1S6KN@1236|Gammaproteobacteria,1XPIJ@135619|Oceanospirillales	135619|Oceanospirillales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_7151687_1	391587.KAOT1_15878	7.82e-28	130.0	COG3146@1|root,COG3146@2|Bacteria,4NI7H@976|Bacteroidetes,1I0KW@117743|Flavobacteriia	976|Bacteroidetes	S	8-amino-7-oxononanoate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB_like
TLS3_k127_7151687_0	634499.EpC_29360	1.118e-50	190.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,3X4MK@551|Erwinia	1236|Gammaproteobacteria	S	Haemolysin-III related	yqfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
TLS3_k127_7151687_2	187272.Mlg_0089	1.276e-21	108.0	COG1988@1|root,COG1988@2|Bacteria,1PCAC@1224|Proteobacteria,1RYI5@1236|Gammaproteobacteria,1X244@135613|Chromatiales	135613|Chromatiales	S	PFAM membrane-bound metal-dependent hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
TLS3_k127_7152423_1	1173025.GEI7407_3289	9.767e-106	357.0	COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria,1H75A@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_7152423_0	926549.KI421517_gene109	1.967e-134	442.0	COG0477@1|root,COG2814@2|Bacteria,4NEQU@976|Bacteroidetes,47KKT@768503|Cytophagia	976|Bacteroidetes	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_7152423_2	929556.Solca_2846	8.723e-42	159.0	COG3708@1|root,COG3708@2|Bacteria,4NQ46@976|Bacteroidetes,1ITC5@117747|Sphingobacteriia	976|Bacteroidetes	K	PFAM Bacterial transcription activator, effector binding domain	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like
TLS3_k127_7152423_3	306263.Cla_0618	1.797e-31	128.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2YMD3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS3_k127_7156264_0	1005048.CFU_1206	1.026e-124	411.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VH9Y@28216|Betaproteobacteria,476JS@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_7156264_2	700598.Niako_5316	2.929e-25	116.0	COG0746@1|root,COG0746@2|Bacteria,4PG92@976|Bacteroidetes,1ITAM@117747|Sphingobacteriia	976|Bacteroidetes	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	-	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS3_k127_7156264_1	1168034.FH5T_21145	3.047e-38	147.0	COG0314@1|root,COG0314@2|Bacteria,4NP1X@976|Bacteroidetes	976|Bacteroidetes	H	Molybdopterin converting factor	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TLS3_k127_7159666_0	502025.Hoch_5091	8.712e-177	566.0	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,42Z7G@68525|delta/epsilon subdivisions,2WU0D@28221|Deltaproteobacteria,2YU48@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_7169065_0	314230.DSM3645_17635	0.000129	54.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,2IZUV@203682|Planctomycetes	203682|Planctomycetes	H	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
TLS3_k127_7177482_0	756272.Plabr_3346	2.161e-165	539.0	COG0733@1|root,COG0733@2|Bacteria,2J29X@203682|Planctomycetes	203682|Planctomycetes	S	Sodium:neurotransmitter symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SNF
TLS3_k127_717938_0	936155.HFELIS_03770	1.083e-17	96.0	COG0859@1|root,COG0859@2|Bacteria,1N5A1@1224|Proteobacteria,42S5Z@68525|delta/epsilon subdivisions,2YP6I@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	COG0859 ADP-heptose LPS heptosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
TLS3_k127_717938_1	1380393.JHVP01000002_gene1943	1.022e-14	82.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4ERHS@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS3_k127_7181998_0	1480694.DC28_08505	2.48e-86	294.0	COG2114@1|root,COG2114@2|Bacteria,2J77D@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_7185275_0	1219072.VHA01S_084_00140	8.146e-15	81.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XTGI@135623|Vibrionales	135623|Vibrionales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	luxO	GO:0000156,GO:0000160,GO:0003674,GO:0003700,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K10912	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00513	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_7185275_1	760142.Hipma_0803	2.049e-14	83.0	COG1639@1|root,COG1639@2|Bacteria,1N38F@1224|Proteobacteria,42UBF@68525|delta/epsilon subdivisions,2WQEF@28221|Deltaproteobacteria,2M6CX@213113|Desulfurellales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_7187346_0	1480694.DC28_14380	0.0	1233.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
TLS3_k127_7194097_1	497965.Cyan7822_2274	3.878e-13	79.0	28J0S@1|root,2Z8XX@2|Bacteria,1G3N4@1117|Cyanobacteria,3KHGW@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7194097_0	771875.Ferpe_2035	2.839e-111	366.0	COG1186@1|root,COG1186@2|Bacteria,2GCJ9@200918|Thermotogae	200918|Thermotogae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS3_k127_7200820_3	338963.Pcar_0066	0.0004646	47.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42URW@68525|delta/epsilon subdivisions,2WMYB@28221|Deltaproteobacteria,43SFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS3_k127_7200820_0	1198232.CYCME_0794	8.123e-95	322.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,1T3X8@1236|Gammaproteobacteria,463UU@72273|Thiotrichales	72273|Thiotrichales	C	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TLS3_k127_7200820_2	526224.Bmur_0021	9.053e-26	116.0	COG1259@1|root,COG1259@2|Bacteria,2J813@203691|Spirochaetes	203691|Spirochaetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
TLS3_k127_7200820_1	880073.Calab_3717	3.172e-35	148.0	COG1232@1|root,COG1232@2|Bacteria,2NQ1W@2323|unclassified Bacteria	2|Bacteria	H	Flavin containing amine oxidoreductase	hemG	-	1.14.19.9,1.3.3.15,1.3.3.4	ko:K00231,ko:K14266	ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130	M00121,M00789,M00790	R03222,R04178,R09570	RC00885,RC00949	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09325	Amino_oxidase
TLS3_k127_7214824_0	483219.LILAB_31135	8.143e-11	74.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
TLS3_k127_7214824_1	1480694.DC28_03670	1.262e-05	49.0	COG0379@1|root,COG0379@2|Bacteria,2JAE2@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
TLS3_k127_72179_1	1304275.C41B8_14055	1.744e-57	212.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
TLS3_k127_72179_0	640081.Dsui_2090	2.877e-97	327.0	COG0583@1|root,COG0583@2|Bacteria,1MV06@1224|Proteobacteria,2VHGD@28216|Betaproteobacteria,2KVJI@206389|Rhodocyclales	206389|Rhodocyclales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_72179_2	1547437.LL06_19060	1.496e-15	78.0	COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,2TQRG@28211|Alphaproteobacteria,43N4P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_72190_0	1355374.JARU01000020_gene912	8.94e-48	174.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS3_k127_72190_1	1385935.N836_10600	5.95e-41	162.0	COG0668@1|root,COG0668@2|Bacteria,1G06A@1117|Cyanobacteria	1117|Cyanobacteria	M	COG0668 Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TLS3_k127_72190_2	1202532.FF52_17373	2.078e-07	64.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia,2P0MK@237|Flavobacterium	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
TLS3_k127_7219741_0	700598.Niako_2732	3.94e-78	273.0	COG3437@1|root,COG4251@1|root,COG3437@2|Bacteria,COG4251@2|Bacteria,4NDUQ@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
TLS3_k127_7219741_1	1131812.JQMS01000001_gene2386	4.77e-29	123.0	COG0745@1|root,COG4251@1|root,COG5278@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,4NFBM@976|Bacteroidetes,1HYZJ@117743|Flavobacteriia,2NTFR@237|Flavobacterium	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
TLS3_k127_7232166_0	1123242.JH636436_gene400	1.374e-36	147.0	COG1055@1|root,COG1055@2|Bacteria,2IY4X@203682|Planctomycetes	203682|Planctomycetes	P	COG1055 Na H antiporter NhaD and related arsenite	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
TLS3_k127_7232166_2	358220.C380_13585	3.473e-16	89.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,4ACAI@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	ompA	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
TLS3_k127_7232166_1	1519464.HY22_14405	3.984e-18	95.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
TLS3_k127_7239531_0	1313301.AUGC01000001_gene1574	4.253e-19	101.0	COG1629@1|root,COG4771@2|Bacteria,4NM9G@976|Bacteroidetes	976|Bacteroidetes	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
TLS3_k127_7239531_3	1089551.KE386572_gene4748	0.0009238	52.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,Response_reg,SpoIIE
TLS3_k127_7239531_2	395494.Galf_1847	3.308e-05	57.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_7239531_1	1286171.EAL2_808p04380	2.653e-06	55.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,25VZ9@186806|Eubacteriaceae	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
TLS3_k127_7249052_0	1007103.AFHW01000069_gene5704	4.388e-187	598.0	COG0397@1|root,COG0397@2|Bacteria,1TQXD@1239|Firmicutes,4HBKH@91061|Bacilli,26U17@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the UPF0061 (SELO) family	M1-1044	-	-	-	-	-	-	-	-	-	-	-	UPF0061
TLS3_k127_7268228_1	1090320.KB900605_gene3394	1.736e-25	113.0	COG2940@1|root,COG2940@2|Bacteria,1Q9DE@1224|Proteobacteria,2VDKT@28211|Alphaproteobacteria,2K32C@204457|Sphingomonadales	204457|Sphingomonadales	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
TLS3_k127_7268228_2	1487923.DP73_15635	1.141e-09	67.0	COG1309@1|root,COG1309@2|Bacteria,1V86J@1239|Firmicutes,24KZ2@186801|Clostridia	186801|Clostridia	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS3_k127_7268228_0	485916.Dtox_1223	3.176e-81	281.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,260E9@186807|Peptococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
TLS3_k127_7279479_0	1287116.X734_29295	4.474e-21	105.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Sulfatase
TLS3_k127_7283391_0	1297581.H919_11569	1.673e-08	67.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,4H9VJ@91061|Bacilli	91061|Bacilli	F	Belongs to the 5'-nucleotidase family	cpdB	-	3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45	ko:K01081,ko:K07004,ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,CHB_HEX_C_1,LTD,LysM,Metallophos,SLH
TLS3_k127_7303194_1	1336241.JAEB01000015_gene1631	2.309e-35	144.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,25UVE@186806|Eubacteriaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
TLS3_k127_7303194_0	445970.ALIPUT_02705	7.226e-81	287.0	COG0486@1|root,COG0486@2|Bacteria,4NECT@976|Bacteroidetes,2FMER@200643|Bacteroidia,22URH@171550|Rikenellaceae	976|Bacteroidetes	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TLS3_k127_7322799_1	1147.D082_21200	3.153e-05	47.0	COG4636@1|root,COG4636@2|Bacteria,1G5E9@1117|Cyanobacteria,1H666@1142|Synechocystis	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_7322799_0	661478.OP10G_0793	2.116e-69	243.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS3_k127_7322799_2	868131.MSWAN_0045	0.0001364	55.0	COG0517@1|root,COG1409@1|root,COG3291@1|root,arCOG02488@1|root,arCOG02555@1|root,arCOG00600@2157|Archaea,arCOG01144@2157|Archaea,arCOG02488@2157|Archaea,arCOG02510@2157|Archaea,arCOG02555@2157|Archaea,2Y3WW@28890|Euryarchaeota,23PKE@183925|Methanobacteria	183925|Methanobacteria	S	TIGRFAM Polymorphic membrane protein, Chlamydia	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Chlam_PMP
TLS3_k127_7322799_3	467200.ACFA01000816_gene5747	0.0005434	53.0	COG2730@1|root,COG2730@2|Bacteria,2GKTY@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase family 5	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CBM_2,Cellulase,fn3
TLS3_k127_7323681_0	402880.MmarC5_0724	7.979e-90	304.0	COG0253@1|root,arCOG02255@2157|Archaea,2XUYX@28890|Euryarchaeota,23QXQ@183939|Methanococci	183939|Methanococci	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS3_k127_7356882_0	1526927.Plano_0099	5.674e-40	159.0	COG2114@1|root,COG2114@2|Bacteria,1V8X9@1239|Firmicutes,4IQCE@91061|Bacilli,26GPU@186818|Planococcaceae	91061|Bacilli	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS3_k127_7361056_0	404589.Anae109_0303	1.238e-67	243.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,42QKZ@68525|delta/epsilon subdivisions,2WJ74@28221|Deltaproteobacteria,2YU8X@29|Myxococcales	28221|Deltaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
TLS3_k127_7365621_0	1118235.CAJH01000047_gene2962	3.205e-81	279.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1X44J@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
TLS3_k127_7365621_2	1385517.N800_06060	0.0009424	46.0	2E5SG@1|root,330GY@2|Bacteria,1NB2M@1224|Proteobacteria,1SCUK@1236|Gammaproteobacteria,1X791@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7379330_0	997346.HMPREF9374_0362	2.21e-92	311.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,27BBV@186824|Thermoactinomycetaceae	91061|Bacilli	F	Phosphorylase superfamily	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS3_k127_7379330_1	511051.CSE_04300	3.349e-06	51.0	COG1003@1|root,COG1003@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	gcvPB	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
TLS3_k127_7382709_1	264462.Bd3083	1.115e-47	175.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2MTQY@213481|Bdellovibrionales,2WJ1W@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	nuoF-2	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TLS3_k127_7382709_0	1125701.HMPREF1221_01161	8.788e-110	377.0	COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,2J5GP@203691|Spirochaetes	203691|Spirochaetes	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
TLS3_k127_7382709_2	754027.HMPREF9554_03137	3.942e-09	66.0	COG4254@1|root,COG4254@2|Bacteria,2J6MW@203691|Spirochaetes	203691|Spirochaetes	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS3_k127_7392480_0	1307761.L21SP2_1191	2.186e-139	451.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
TLS3_k127_7397731_0	1123228.AUIH01000034_gene2782	1.663e-64	226.0	COG0500@1|root,COG0500@2|Bacteria,1RDRV@1224|Proteobacteria,1S2T5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_7397731_2	742766.HMPREF9455_02896	1.188e-11	72.0	COG3449@1|root,COG3449@2|Bacteria	2|Bacteria	K	DNA topoisomerase (ATP-hydrolyzing) inhibitor activity	yhgE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	DUF4153,GyrI-like,HTH_18,SOUL
TLS3_k127_7397731_1	243231.GSU0080	5.604e-57	210.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43T3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase S1 and S6, chymotrypsin Hap	degQ	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
TLS3_k127_7399463_1	497964.CfE428DRAFT_4918	9.99e-138	455.0	COG0369@1|root,COG0369@2|Bacteria,46SEE@74201|Verrucomicrobia	74201|Verrucomicrobia	P	oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
TLS3_k127_7399463_0	1123070.KB899261_gene2102	1.478e-190	608.0	COG0155@1|root,COG0155@2|Bacteria,46TDQ@74201|Verrucomicrobia,2ITQ2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Nitrite and sulphite reductase 4Fe-4S domain	-	-	-	-	-	-	-	-	-	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS3_k127_7421972_2	1313301.AUGC01000014_gene2506	1.066e-46	172.0	COG1490@1|root,COG1490@2|Bacteria,4NNFF@976|Bacteroidetes	976|Bacteroidetes	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS3_k127_7421972_1	1033802.SSPSH_002542	9.073e-53	194.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,1S1SK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_7421972_3	1192034.CAP_5313	2.696e-41	158.0	COG4276@1|root,COG4276@2|Bacteria,1R0BS@1224|Proteobacteria,43CU7@68525|delta/epsilon subdivisions,2X81U@28221|Deltaproteobacteria,2Z3JC@29|Myxococcales	28221|Deltaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
TLS3_k127_7421972_0	1196028.ALEF01000014_gene2725	1.13e-101	346.0	COG0702@1|root,COG0702@2|Bacteria,1UX1J@1239|Firmicutes,4IJQE@91061|Bacilli,4C6I2@84406|Virgibacillus	91061|Bacilli	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS3_k127_7427879_0	246194.CHY_2074	1.112e-96	335.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,42ETI@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_7439708_1	1385935.N836_07015	6.403e-09	64.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	CMAS,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25
TLS3_k127_7439708_0	572546.Arcpr_0656	8.917e-54	202.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,245XG@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS3_k127_7440247_0	671143.DAMO_1846	1.315e-89	316.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
TLS3_k127_7440247_1	1211115.ALIQ01000196_gene65	2.851e-40	162.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria	1224|Proteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS3_k127_7451267_0	309807.SRU_0869	3.459e-39	151.0	2CBKC@1|root,32RTJ@2|Bacteria,4NTE7@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7451763_4	768670.Calni_1176	1.376e-05	51.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_16,TPR_2,TPR_8
TLS3_k127_7451763_1	4952.CAG82336	3.769e-65	234.0	COG0657@1|root,KOG1515@2759|Eukaryota,3A1CU@33154|Opisthokonta,3NZ98@4751|Fungi,3QKHV@4890|Ascomycota,3RVXJ@4891|Saccharomycetes	4751|Fungi	V	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS3_k127_7451763_3	378806.STAUR_0951	6.089e-24	109.0	COG1309@1|root,COG1309@2|Bacteria,1N8UC@1224|Proteobacteria,43DN7@68525|delta/epsilon subdivisions,2X291@28221|Deltaproteobacteria,2YYN1@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_7451763_0	378806.STAUR_0950	1.2e-85	291.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,43EW6@68525|delta/epsilon subdivisions,2X285@28221|Deltaproteobacteria,2YUSM@29|Myxococcales	28221|Deltaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_7451763_2	1196083.SALWKB12_0914	3.63e-31	129.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,2KPVQ@206351|Neisseriales	206351|Neisseriales	O	Peptidase, U32 family	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
TLS3_k127_7451885_0	927677.ALVU02000001_gene3918	4.231e-07	63.0	COG2208@1|root,COG3850@1|root,COG2208@2|Bacteria,COG3850@2|Bacteria,1G3MK@1117|Cyanobacteria,1H4MY@1142|Synechocystis	1117|Cyanobacteria	KT	Sigma factor PP2C-like phosphatases	icfG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,HAMP,HisKA,Response_reg,SpoIIE
TLS3_k127_7462794_1	1117647.M5M_08075	8.536e-46	175.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1RMZB@1236|Gammaproteobacteria,1J8YA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
TLS3_k127_7462794_2	339670.Bamb_5077	6.354e-21	102.0	COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,2VJR8@28216|Betaproteobacteria,1K60Y@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS3_k127_7462794_0	373903.Hore_23250	1.758e-75	261.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3WB27@53433|Halanaerobiales	186801|Clostridia	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_7465904_3	1515615.HQ41_03380	1.85e-19	95.0	COG1519@1|root,COG1519@2|Bacteria,4NESA@976|Bacteroidetes,2FPNI@200643|Bacteroidia,22XA0@171551|Porphyromonadaceae	976|Bacteroidetes	M	transferase	waaA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
TLS3_k127_7465904_2	1122217.KB899589_gene320	6.361e-82	277.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,4H2XP@909932|Negativicutes	909932|Negativicutes	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS3_k127_7465904_1	1341151.ASZU01000003_gene2479	2.202e-156	505.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H9U4@91061|Bacilli,27B75@186824|Thermoactinomycetaceae	91061|Bacilli	O	ClpX C4-type zinc finger	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS3_k127_7465904_0	639282.DEFDS_0195	2.631e-158	516.0	COG0466@1|root,COG0466@2|Bacteria,2GEQJ@200930|Deferribacteres	200930|Deferribacteres	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
TLS3_k127_7466818_0	1254432.SCE1572_47520	9.133e-18	89.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,42P4Q@68525|delta/epsilon subdivisions,2WK5G@28221|Deltaproteobacteria,2YU4N@29|Myxococcales	28221|Deltaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS3_k127_746798_0	248742.XP_005646923.1	1.944e-50	186.0	COG4240@1|root,KOG2878@2759|Eukaryota,37NTW@33090|Viridiplantae,34K12@3041|Chlorophyta	3041|Chlorophyta	S	D-glycerate 3-kinase	-	-	2.7.1.31	ko:K15918	ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00561,map00630,map01100,map01110,map01130,map01200	M00532	R01514	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	-
TLS3_k127_7468073_0	1408473.JHXO01000007_gene752	1.943e-29	124.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,4NGZ0@976|Bacteroidetes	976|Bacteroidetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9
TLS3_k127_7468073_1	655813.HMPREF8579_0987	2.678e-18	91.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,4HAAZ@91061|Bacilli,1WPHM@1303|Streptococcus oralis	91061|Bacilli	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS3_k127_7474353_1	1453496.AT03_03420	8.32e-10	68.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1RQMH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Sensor protein basS	basS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0042221,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07643,ko:K07645	ko01503,ko02020,ko02024,map01503,map02020,map02024	M00451,M00453,M00721,M00722	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS3_k127_7474353_0	1121271.AUCM01000002_gene4160	1.731e-21	102.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_7474615_0	765420.OSCT_0756	1.032e-09	72.0	COG3850@1|root,COG3850@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,HisKA_7TM,MFS_1
TLS3_k127_7490760_0	439235.Dalk_0859	4.39e-29	134.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TLS3_k127_7492081_0	1232410.KI421413_gene479	2.23e-21	102.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42TW3@68525|delta/epsilon subdivisions,2WPZS@28221|Deltaproteobacteria,43W40@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Shikimate kinase	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS3_k127_7492081_1	1167006.UWK_00231	2.465e-06	49.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,42N54@68525|delta/epsilon subdivisions,2WMGU@28221|Deltaproteobacteria,2MI8K@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TLS3_k127_7496583_0	237368.SCABRO_01544	6.928e-17	94.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
TLS3_k127_7496583_1	1184267.A11Q_1086	3.001e-08	66.0	COG4254@1|root,COG4254@2|Bacteria,1NATC@1224|Proteobacteria,42X7Q@68525|delta/epsilon subdivisions,2MU59@213481|Bdellovibrionales,2WTAB@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
TLS3_k127_7501344_0	1250232.JQNJ01000001_gene30	2.442e-127	415.0	COG1052@1|root,COG1052@2|Bacteria,4NF1R@976|Bacteroidetes,1HZJN@117743|Flavobacteriia	976|Bacteroidetes	CH	D-isomer specific 2-hydroxyacid dehydrogenase	ldhA	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_7508042_0	706587.Desti_0932	3.732e-142	465.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2WIYI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Sodium sulphate symporter	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS3_k127_7508042_2	1453500.AT05_11295	4.108e-57	208.0	COG2067@1|root,COG2067@2|Bacteria,4NQHN@976|Bacteroidetes,1I6SN@117743|Flavobacteriia	976|Bacteroidetes	I	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
TLS3_k127_7508042_1	1175306.GWL_32270	1.854e-136	440.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,472KX@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS3_k127_7516779_1	1121904.ARBP01000001_gene5944	7.116e-71	247.0	COG0446@1|root,COG0446@2|Bacteria,4NET1@976|Bacteroidetes,47JW2@768503|Cytophagia	976|Bacteroidetes	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS3_k127_7516779_0	926549.KI421517_gene3946	2.026e-162	521.0	COG0348@1|root,COG0348@2|Bacteria,4NHSX@976|Bacteroidetes,47KC5@768503|Cytophagia	976|Bacteroidetes	C	4Fe-4S dicluster domain	yccM_2	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7,Fer4_9
TLS3_k127_7516779_2	1089550.ATTH01000001_gene2217	2.736e-55	202.0	COG3176@1|root,COG3176@2|Bacteria,4PKEK@976|Bacteroidetes	976|Bacteroidetes	S	hemolysin	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
TLS3_k127_7516779_5	382464.ABSI01000005_gene1399	5.064e-27	118.0	COG2318@1|root,COG2318@2|Bacteria,46WF2@74201|Verrucomicrobia,2IWE9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7516779_4	1056512.D515_04886	1.87e-32	138.0	COG3332@1|root,COG3332@2|Bacteria,1RE1W@1224|Proteobacteria,1S59Q@1236|Gammaproteobacteria,1XU3T@135623|Vibrionales	135623|Vibrionales	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
TLS3_k127_7516779_3	382464.ABSI01000005_gene1401	4.556e-47	182.0	COG0189@1|root,COG0586@1|root,COG0189@2|Bacteria,COG0586@2|Bacteria,46UXZ@74201|Verrucomicrobia	74201|Verrucomicrobia	HJ	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_7525291_0	1125863.JAFN01000001_gene2585	2.199e-136	441.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS3_k127_7532223_0	596151.DesfrDRAFT_2590	6.084e-53	194.0	COG0279@1|root,COG2605@1|root,COG0279@2|Bacteria,COG2605@2|Bacteria,1QWU7@1224|Proteobacteria,42QI3@68525|delta/epsilon subdivisions,2X8DE@28221|Deltaproteobacteria,2MGSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,SIS_2
TLS3_k127_7532223_1	1280.SAXN108_0732	0.0006493	49.0	COG1388@1|root,COG3942@1|root,COG1388@2|Bacteria,COG3942@2|Bacteria,1V8WM@1239|Firmicutes,4I27S@91061|Bacilli,4GX44@90964|Staphylococcaceae	91061|Bacilli	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,LysM
TLS3_k127_7533742_0	1140.Synpcc7942_2303	1.267e-57	210.0	COG0294@1|root,COG0294@2|Bacteria,1G050@1117|Cyanobacteria,1GZAI@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796,ko:K18824	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Pterin_bind
TLS3_k127_7533742_1	1444306.JFZC01000041_gene81	9.322e-32	130.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,26NN5@186821|Sporolactobacillaceae	91061|Bacilli	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
TLS3_k127_7534477_0	1123503.KB908056_gene1425	1.403e-110	366.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,2KFV8@204458|Caulobacterales	204458|Caulobacterales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS3_k127_7534477_1	648996.Theam_1095	5.864e-13	70.0	COG0115@1|root,COG0115@2|Bacteria,2G3W3@200783|Aquificae	200783|Aquificae	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS3_k127_7542752_0	91464.S7335_3111	1.775e-05	57.0	COG5662@1|root,COG5662@2|Bacteria,1GQIT@1117|Cyanobacteria	1117|Cyanobacteria	K	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
TLS3_k127_7551525_0	1123518.ARWI01000001_gene1939	2.032e-05	48.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,45ZMN@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_7567966_0	1158760.AQXP01000049_gene641	8.679e-12	77.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_756803_0	1242864.D187_000778	1.276e-33	148.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,42N4N@68525|delta/epsilon subdivisions,2WKJ1@28221|Deltaproteobacteria,2YU9U@29|Myxococcales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
TLS3_k127_7573370_1	945713.IALB_2033	4.214e-38	149.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_7573370_0	485918.Cpin_5868	2.93e-101	337.0	COG3239@1|root,COG3239@2|Bacteria,4NH2H@976|Bacteroidetes,1IQFV@117747|Sphingobacteriia	976|Bacteroidetes	I	PFAM Fatty acid desaturase	-	-	1.14.18.5,1.14.19.17	ko:K04712	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00094,M00099	R06519	RC00824	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_desaturase,Lipid_DES
TLS3_k127_7574875_1	1116472.MGMO_45c00700	4.833e-39	154.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,1XEI4@135618|Methylococcales	135618|Methylococcales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
TLS3_k127_7574875_0	1265845.PWEIH_00780	9.742e-65	230.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,26MDG@186820|Listeriaceae	91061|Bacilli	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
TLS3_k127_75753_0	1210884.HG799463_gene9826	8.457e-28	118.0	COG0412@1|root,COG0412@2|Bacteria,2IZ0R@203682|Planctomycetes	203682|Planctomycetes	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS3_k127_7577443_0	864051.BurJ1DRAFT_2252	3.05e-76	279.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KN6Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	CHASE2	-	-	2.7.13.3	ko:K10715	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE2,HATPase_c,HisKA,Hpt,Response_reg
TLS3_k127_7583925_1	1121413.JMKT01000008_gene1044	1.378e-11	73.0	COG1652@1|root,COG1652@2|Bacteria,1N2HY@1224|Proteobacteria,42URJ@68525|delta/epsilon subdivisions,2WQ66@28221|Deltaproteobacteria,2MC9F@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398,LysM
TLS3_k127_7583925_0	316067.Geob_0681	5.185e-193	615.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,43T9E@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS3_k127_7587493_0	1191523.MROS_1872	1.208e-58	214.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K03641,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.2	-	-	Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2
TLS3_k127_7587493_1	1123073.KB899243_gene824	9.401e-51	196.0	COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,1RQRZ@1236|Gammaproteobacteria,1X4YB@135614|Xanthomonadales	135614|Xanthomonadales	V	Inner membrane protein involved in colicin E2 resistance	creD	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
TLS3_k127_7588411_1	391009.Tmel_1885	5.954e-63	229.0	COG0404@1|root,COG0404@2|Bacteria,2GC8B@200918|Thermotogae	200918|Thermotogae	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2007,GCV_T,GCV_T_C
TLS3_k127_7588411_2	1296415.JACC01000006_gene1572	0.0003111	52.0	COG1595@1|root,COG1595@2|Bacteria,4NNP4@976|Bacteroidetes,1I284@117743|Flavobacteriia,2YGWU@290174|Aquimarina	976|Bacteroidetes	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_7588411_0	1408433.JHXV01000006_gene2696	2.529e-107	359.0	COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia,2PAC8@246874|Cryomorphaceae	976|Bacteroidetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS3_k127_7591480_1	1150600.ADIARSV_3599	2.403e-21	96.0	COG0415@1|root,COG0415@2|Bacteria,4NEDW@976|Bacteroidetes,1IQZJ@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS3_k127_7591480_0	1242864.D187_003660	3.14e-142	468.0	COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,42N8N@68525|delta/epsilon subdivisions,2WKR3@28221|Deltaproteobacteria,2YUA0@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
TLS3_k127_7593820_0	313628.LNTAR_14402	2.645e-51	203.0	COG0564@1|root,COG0564@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	-	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,Rhodanese
TLS3_k127_7593820_2	906968.Trebr_1979	3.977e-06	57.0	2EMQ9@1|root,33FCS@2|Bacteria	2|Bacteria	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS3_k127_7593820_1	1122613.ATUP01000001_gene2109	2.649e-16	83.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,43W6A@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_7596440_0	118005.AWNK01000011_gene154	1.506e-101	343.0	COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria	2|Bacteria	T	EAL domain	yjcC	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,Peripla_BP_3
TLS3_k127_7596482_2	1415166.NONO_c20780	4.563e-43	167.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FXBC@85025|Nocardiaceae	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_7596482_1	313606.M23134_04048	3.467e-138	454.0	COG0446@1|root,COG0446@2|Bacteria,4NET1@976|Bacteroidetes,47JW2@768503|Cytophagia	976|Bacteroidetes	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS3_k127_7596482_0	1415779.JOMH01000001_gene2621	3.692e-155	497.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria,1X68V@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS3_k127_7596518_0	744872.Spica_0773	3.534e-31	126.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_7596518_1	744872.Spica_0772	8.211e-11	72.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
TLS3_k127_760518_1	679926.Mpet_0666	1.545e-42	162.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS3_k127_760518_2	1313293.BAN_0039400	2.088e-38	156.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J7KD@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
TLS3_k127_760518_0	596152.DesU5LDRAFT_2436	4.249e-49	186.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WM9R@28221|Deltaproteobacteria,2MG33@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
TLS3_k127_7615535_0	1158338.JNLJ01000001_gene178	4.003e-05	57.0	COG0457@1|root,COG0457@2|Bacteria	1158338.JNLJ01000001_gene178|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7615535_1	1304275.C41B8_07202	0.0005631	49.0	COG0596@1|root,COG0596@2|Bacteria,1RDWF@1224|Proteobacteria,1S564@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	EstX protein	estX	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS3_k127_7615771_0	1278073.MYSTI_00814	5.511e-65	233.0	COG1520@1|root,COG2234@1|root,COG1520@2|Bacteria,COG2234@2|Bacteria,1NI1E@1224|Proteobacteria,430IZ@68525|delta/epsilon subdivisions,2WW3C@28221|Deltaproteobacteria,2YYH1@29|Myxococcales	28221|Deltaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_M10
TLS3_k127_7617839_1	360104.CCC13826_2038	1.071e-11	73.0	COG0790@1|root,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	DUF900,Sel1,TPR_8
TLS3_k127_7617839_0	573061.Clocel_4180	8.049e-14	83.0	COG5492@1|root,COG5492@2|Bacteria,1VX47@1239|Firmicutes,24C5W@186801|Clostridia,36H1I@31979|Clostridiaceae	186801|Clostridia	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
TLS3_k127_7627953_0	1437425.CSEC_0326	2.459e-50	185.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_7640414_1	1163409.UUA_04173	6.813e-14	79.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1X32F@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS3_k127_7640414_0	452637.Oter_4364	1.449e-67	233.0	COG5293@1|root,COG5293@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2326
TLS3_k127_7644156_0	1121447.JONL01000002_gene1987	7.077e-07	60.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X6YR@28221|Deltaproteobacteria,2MH8N@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg,dCache_1
TLS3_k127_764701_0	744872.Spica_1230	1.86e-36	148.0	COG1253@1|root,COG1253@2|Bacteria,2J61P@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1253 Hemolysins and related protein containing CBS domains	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
TLS3_k127_764701_1	515635.Dtur_1328	7.718e-17	87.0	COG0319@1|root,COG0319@2|Bacteria	2|Bacteria	C	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029	-	-	-	UPF0054
TLS3_k127_7649589_0	929703.KE386491_gene1361	6.571e-57	221.0	COG1368@1|root,COG1368@2|Bacteria,4NIAA@976|Bacteroidetes,47MRX@768503|Cytophagia	976|Bacteroidetes	M	Sulfatase	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
TLS3_k127_7649950_0	1313301.AUGC01000010_gene956	9.798e-176	562.0	COG1830@1|root,COG1830@2|Bacteria,4NEUM@976|Bacteroidetes	976|Bacteroidetes	G	Aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
TLS3_k127_7649950_1	246197.MXAN_1582	1.964e-28	119.0	2CNQU@1|root,32SHJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS3_k127_7649950_2	1068978.AMETH_1192	2.85e-18	96.0	COG0596@1|root,COG0596@2|Bacteria,2I51U@201174|Actinobacteria,4E7Q6@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_7657196_1	59894.ENSFALP00000000264	1.508e-06	59.0	COG0515@1|root,KOG0192@2759|Eukaryota,39SGA@33154|Opisthokonta,3BFNI@33208|Metazoa,3CZ58@33213|Bilateria,483MU@7711|Chordata,48XFT@7742|Vertebrata,4GR9A@8782|Aves	33208|Metazoa	T	Ankyrin repeat and protein kinase domain-containing protein 1	ANKK1	-	2.7.11.1	ko:K16289	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,Pkinase,Pkinase_Tyr
TLS3_k127_7657196_0	1406840.Q763_15180	9.164e-30	121.0	COG0346@1|root,COG0346@2|Bacteria,4NNNG@976|Bacteroidetes,1I1XF@117743|Flavobacteriia,2NWAI@237|Flavobacterium	976|Bacteroidetes	E	Glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_7661886_0	1118235.CAJH01000025_gene1825	9.89e-13	76.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1X456@135614|Xanthomonadales	135614|Xanthomonadales	J	Elongation factor P--(R)-beta-lysine ligase	lysS	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
TLS3_k127_7662092_0	717231.Flexsi_1562	1.442e-50	184.0	COG1573@1|root,COG1573@2|Bacteria,2GFD7@200930|Deferribacteres	200930|Deferribacteres	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS3_k127_7665461_3	749222.Nitsa_1424	2.784e-21	100.0	COG4636@1|root,COG4636@2|Bacteria,1RI9E@1224|Proteobacteria,42SV0@68525|delta/epsilon subdivisions,2YPQ6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_7665461_7	1122604.JONR01000048_gene1002	3.019e-05	51.0	2CG3H@1|root,32MES@2|Bacteria,1P5A1@1224|Proteobacteria,1SUJW@1236|Gammaproteobacteria,1XBNT@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7665461_1	402777.KB235903_gene1652	3.774e-66	243.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G4ED@1117|Cyanobacteria,1HA0Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,Guanylate_cyc
TLS3_k127_7665461_2	236814.IX39_06470	7.309e-47	185.0	COG1194@1|root,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,1HY00@117743|Flavobacteriia,3ZPVX@59732|Chryseobacterium	976|Bacteroidetes	L	Adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
TLS3_k127_7665461_0	441620.Mpop_1087	1.281e-69	252.0	COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,2TU1V@28211|Alphaproteobacteria,1JRR6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Guanine deaminase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS3_k127_7665461_5	1144319.PMI16_02327	1.887e-08	58.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,473PM@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	ATPases associated with a variety of cellular activities	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS3_k127_7665991_0	574087.Acear_0683	1.513e-100	349.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,3WADB@53433|Halanaerobiales	186801|Clostridia	J	glycyl-tRNA synthetase, tetrameric type, beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS3_k127_7665991_1	986075.CathTA2_1548	1.048e-09	70.0	COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,4HBBA@91061|Bacilli	91061|Bacilli	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
TLS3_k127_7666667_0	293826.Amet_1755	2.816e-09	68.0	COG2304@1|root,COG2304@2|Bacteria,1U8R5@1239|Firmicutes,24F1T@186801|Clostridia,36PN4@31979|Clostridiaceae	186801|Clostridia	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA
TLS3_k127_7666667_1	1149133.ppKF707_0594	0.0001531	49.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1YCWZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	U	Belongs to the peptidase S26 family	lepB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS3_k127_7667459_1	1304888.ATWF01000002_gene458	6.685e-39	148.0	COG0757@1|root,COG0757@2|Bacteria,2GFQ3@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS3_k127_7667459_0	767434.Fraau_2914	1.315e-74	264.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1X42C@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
TLS3_k127_7679298_4	449447.MAE_55720	6.735e-22	97.0	COG1724@1|root,COG1724@2|Bacteria,1G9Z7@1117|Cyanobacteria	1117|Cyanobacteria	N	PFAM YcfA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
TLS3_k127_7679298_3	65093.PCC7418_1677	6.397e-24	101.0	COG1598@1|root,COG1598@2|Bacteria,1G9KW@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7679298_0	1089548.KI783301_gene2140	2.232e-73	254.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,3WE00@539002|Bacillales incertae sedis	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
TLS3_k127_7679298_2	28042.GU90_10375	1.207e-32	133.0	COG3502@1|root,COG3542@1|root,COG3502@2|Bacteria,COG3542@2|Bacteria,2IFG5@201174|Actinobacteria,4E5NZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5,DUF952
TLS3_k127_7679298_1	1207076.ALAT01000198_gene1172	1.352e-38	151.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,1S6PJ@1236|Gammaproteobacteria,1Z3BQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS3_k127_7694836_1	1027273.GZ77_04985	5.43e-13	70.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
TLS3_k127_7694836_0	264732.Moth_1337	2.927e-132	432.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_76960_2	330214.NIDE4192	8.994e-28	126.0	COG4783@1|root,COG4783@2|Bacteria,3J19Q@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS3_k127_76960_1	1094466.KQS_00165	1.731e-44	175.0	COG4269@1|root,COG4269@2|Bacteria,4NI7F@976|Bacteroidetes,1I85H@117743|Flavobacteriia,2NTM3@237|Flavobacterium	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF898)	-	-	-	-	-	-	-	-	-	-	-	-	DUF898
TLS3_k127_76960_0	41431.PCC8801_4230	2.269e-92	325.0	COG1018@1|root,COG1018@2|Bacteria,1G49Z@1117|Cyanobacteria,3KIM4@43988|Cyanothece	1117|Cyanobacteria	C	oxidoreductase FAD NAD(P)-binding	-	-	-	ko:K21832	-	-	-	-	ko00000	-	-	-	FAD_binding_6,FHA,Fer2,NAD_binding_1
TLS3_k127_76960_3	1527444.ucyna2_00487	6.756e-10	61.0	COG0348@1|root,COG5126@1|root,COG0348@2|Bacteria,COG5126@2|Bacteria,1FZVX@1117|Cyanobacteria	1117|Cyanobacteria	CT	cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_1,EF-hand_5,EF-hand_7,EF-hand_8,Fer4_5
TLS3_k127_7704021_0	941770.GL622178_gene166	1.716e-63	225.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,3F3V9@33958|Lactobacillaceae	91061|Bacilli	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_7704021_1	1489678.RDMS_04030	3.961e-46	175.0	COG0606@1|root,COG0606@2|Bacteria,1WI18@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ATPase with chaperone activity	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS3_k127_7704051_1	91464.S7335_1042	4.316e-30	123.0	COG0451@1|root,COG0451@2|Bacteria,1G559@1117|Cyanobacteria	1117|Cyanobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_7704051_0	83406.HDN1F_00160	1.239e-95	323.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	nrp	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Epimerase,NAD_binding_10,NAD_binding_4
TLS3_k127_7707840_0	1121472.AQWN01000002_gene2107	1.905e-23	105.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,262C8@186807|Peptococcaceae	186801|Clostridia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS01470	ACPS
TLS3_k127_7707840_1	861454.HMPREF9099_02827	0.0003264	50.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,27JA1@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS3_k127_7708952_0	1101195.Meth11DRAFT_1545	4.515e-122	409.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,2W0WB@28216|Betaproteobacteria,2KKXQ@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
TLS3_k127_7710217_0	304371.MCP_2179	1.753e-06	57.0	COG0500@1|root,arCOG02702@2157|Archaea,2XWS9@28890|Euryarchaeota,2NAVE@224756|Methanomicrobia	224756|Methanomicrobia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS3_k127_7715571_0	1191523.MROS_0721	3.248e-126	415.0	COG1932@1|root,COG1932@2|Bacteria	2|Bacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS3_k127_7715571_1	744872.Spica_2526	8.601e-52	209.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2JBDH@203691|Spirochaetes	2|Bacteria	KT	7TM diverse intracellular signalling	rsbW	-	2.4.1.12,3.1.3.3	ko:K00694,ko:K07315,ko:K20977	ko00500,ko01100,ko02020,ko02025,ko02026,map00500,map01100,map02020,map02025,map02026	M00820	R02889	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02022,ko03021	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	HATPase_c_2,MatE,SpoIIE
TLS3_k127_7715692_1	2903.EOD14036	4.964e-25	121.0	KOG4441@1|root,KOG4441@2759|Eukaryota	2759|Eukaryota	KLT	protein ubiquitination	-	-	-	ko:K10454,ko:K10457	-	-	-	-	ko00000,ko04121	-	-	-	Kelch_1
TLS3_k127_7715692_0	1227349.C170_06564	9.503e-73	250.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,4HFTY@91061|Bacilli,26RMU@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS3_k127_7715692_2	1408439.JHXW01000002_gene705	1.28e-14	73.0	COG0065@1|root,COG0065@2|Bacteria,379KW@32066|Fusobacteria	32066|Fusobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS3_k127_7722378_2	526227.Mesil_2000	8.983e-32	128.0	COG0735@1|root,COG0735@2|Bacteria,1WJYT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS3_k127_7722378_3	380358.XALC_0155	3.759e-05	52.0	2DRCV@1|root,33B8R@2|Bacteria,1R3NN@1224|Proteobacteria,1SIBE@1236|Gammaproteobacteria,1X8WU@135614|Xanthomonadales	135614|Xanthomonadales	S	MerC mercury resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MerC
TLS3_k127_7722378_0	909663.KI867150_gene2380	5.061e-64	232.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
TLS3_k127_7722378_1	483219.LILAB_13180	1.953e-42	171.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2X4RT@28221|Deltaproteobacteria,2YZGD@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_7726368_0	1265505.ATUG01000001_gene4101	1.178e-36	162.0	COG3209@1|root,COG3266@1|root,COG3209@2|Bacteria,COG3266@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
TLS3_k127_7727198_1	478741.JAFS01000002_gene940	1.088e-12	72.0	COG0469@1|root,COG0469@2|Bacteria,46X3X@74201|Verrucomicrobia,37H8R@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Pyruvate kinase, barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PK
TLS3_k127_7728506_6	1284352.AOIG01000021_gene3963	5.989e-11	74.0	COG0596@1|root,COG0596@2|Bacteria,1UI50@1239|Firmicutes,4ISDP@91061|Bacilli,2772B@186822|Paenibacillaceae	91061|Bacilli	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_7728506_2	868864.Dester_0378	4.406e-41	162.0	COG0130@1|root,COG0130@2|Bacteria,2G40M@200783|Aquificae	200783|Aquificae	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
TLS3_k127_7728506_4	1191523.MROS_1415	4.888e-19	91.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS3_k127_7728506_5	1048983.EL17_13515	1.179e-18	89.0	COG0227@1|root,COG0227@2|Bacteria,4NS7Q@976|Bacteroidetes,47R5P@768503|Cytophagia	976|Bacteroidetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS3_k127_7728506_0	796606.BMMGA3_15130	2.486e-102	346.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HD4F@91061|Bacilli,1ZQW9@1386|Bacillus	91061|Bacilli	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS3_k127_7728506_1	289376.THEYE_A1762	3.276e-73	259.0	COG0019@1|root,COG0019@2|Bacteria	2|Bacteria	E	diaminopimelate decarboxylase activity	speC	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS3_k127_7728506_3	497964.CfE428DRAFT_0789	1.144e-36	145.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_7728574_1	1304876.AZVC01000009_gene3468	8.893e-96	321.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
TLS3_k127_7728574_0	768710.DesyoDRAFT_2788	4.112e-109	364.0	COG0330@1|root,COG0330@2|Bacteria,1TR6S@1239|Firmicutes,24A7V@186801|Clostridia	186801|Clostridia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
TLS3_k127_7744453_0	498848.TaqDRAFT_4878	5.852e-07	63.0	COG4447@1|root,COG4447@2|Bacteria,1WJIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7750792_0	118168.MC7420_7975	2.913e-27	120.0	COG0666@1|root,COG0666@2|Bacteria,1G0E1@1117|Cyanobacteria,1H7BV@1150|Oscillatoriales	1117|Cyanobacteria	S	COG0666 FOG Ankyrin repeat	ank	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
TLS3_k127_775534_0	1047013.AQSP01000140_gene2498	2.686e-11	72.0	COG1597@1|root,COG1597@2|Bacteria,2NS0F@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS3_k127_7756109_1	67356.KL575673_gene4338	3.094e-08	61.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysNC	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
TLS3_k127_7756109_0	1082933.MEA186_04891	6.553e-40	158.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,43GW6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
TLS3_k127_7760495_2	545694.TREPR_3772	2.539e-09	66.0	COG2703@1|root,COG2703@2|Bacteria,2J7CC@203691|Spirochaetes	203691|Spirochaetes	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_7760495_3	1307761.L21SP2_0538	6.274e-09	58.0	2CG1E@1|root,2ZMPU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7760495_1	857293.CAAU_0949	3.345e-16	88.0	COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia,36JBF@31979|Clostridiaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
TLS3_k127_7760495_0	866536.Belba_3492	3.587e-116	379.0	COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,47JIN@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_7761198_0	880072.Desac_2326	1.39e-104	355.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria,2MS6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_7761198_1	1380386.JIAW01000002_gene5523	1.046e-73	251.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,2329G@1762|Mycobacteriaceae	201174|Actinobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS3_k127_7771036_0	1123401.JHYQ01000020_gene952	2.904e-61	215.0	COG1791@1|root,COG1791@2|Bacteria,1RCZD@1224|Proteobacteria,1S42U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway	mtnD	GO:0000096,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0010309,GO:0016491,GO:0016701,GO:0016702,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051213,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.13.11.53,1.13.11.54	ko:K08967	ko00270,ko01100,map00270,map01100	M00034	R07363,R07364	RC01866,RC02018,RC02118	ko00000,ko00001,ko00002,ko01000	-	-	iYL1228.KPN_00643	ARD
TLS3_k127_7771036_1	755732.Fluta_2108	2.722e-37	148.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	mtnB	-	3.1.3.87,4.1.2.17,4.2.1.109	ko:K01628,ko:K08964,ko:K08966	ko00051,ko00270,ko01100,ko01120,map00051,map00270,map01100,map01120	M00034	R02262,R07392,R07394	RC00603,RC00604,RC01939,RC02074	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
TLS3_k127_7771425_1	1278073.MYSTI_01148	1.648e-38	147.0	COG1024@1|root,COG1024@2|Bacteria,1R3Q4@1224|Proteobacteria	1224|Proteobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_7771425_0	1122918.KB907262_gene624	1.516e-59	215.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,4HACA@91061|Bacilli,26QQR@186822|Paenibacillaceae	91061|Bacilli	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS3_k127_7775726_0	351348.Maqu_2652	7.624e-104	353.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,465AN@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
TLS3_k127_7776131_1	526227.Mesil_1787	5.062e-47	174.0	COG0624@1|root,COG0624@2|Bacteria,1WIRV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	3.5.1.116	ko:K18151	ko00230,ko01100,ko01120,map00230,map01100,map01120	-	R00469	RC00153,RC02798,RC02805	ko00000,ko00001,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_7776131_2	1038862.KB893842_gene333	6.264e-35	139.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2UGI0@28211|Alphaproteobacteria,3K0NB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS3_k127_7776131_0	1089547.KB913013_gene2253	5.921e-98	325.0	COG0580@1|root,COG0580@2|Bacteria,4NEFK@976|Bacteroidetes,47KUR@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the MIP aquaporin (TC 1.A.8) family	glpF	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
TLS3_k127_7776131_3	1158318.ATXC01000001_gene1297	1.301e-16	91.0	COG0681@1|root,COG0681@2|Bacteria,2G41Z@200783|Aquificae	200783|Aquificae	U	Signal peptidase I	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS3_k127_7776131_4	1437425.CSEC_0326	3.374e-16	79.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_7781969_0	1185876.BN8_06297	1.424e-146	475.0	COG0649@1|root,COG0649@2|Bacteria,4NF02@976|Bacteroidetes,47KBK@768503|Cytophagia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS3_k127_7782645_1	215803.DB30_4130	1.816e-08	66.0	COG4676@1|root,COG4676@2|Bacteria,1Q2DI@1224|Proteobacteria,437ZR@68525|delta/epsilon subdivisions,2X39P@28221|Deltaproteobacteria,2YV0B@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7782645_0	289377.HL41_00705	4.443e-40	159.0	COG0266@1|root,COG0266@2|Bacteria,2GH1J@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS3_k127_77832_0	1496688.ER33_09320	4.381e-66	236.0	COG4615@1|root,COG4615@2|Bacteria,1G2TH@1117|Cyanobacteria	1117|Cyanobacteria	V	Cyclic peptide transporter	-	-	-	ko:K06160	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.113.2	-	-	ABC_membrane,ABC_tran
TLS3_k127_77832_1	314275.MADE_1013900	3.982e-43	163.0	COG1216@1|root,COG1216@2|Bacteria,1NWNH@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_7791528_0	391615.ABSJ01000018_gene77	9.533e-07	56.0	COG2239@1|root,COG2239@2|Bacteria,1RCPU@1224|Proteobacteria,1S1ZV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7802711_0	1280954.HPO_18260	4.004e-16	89.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,43WIZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	KQ	transcriptional	arsR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_31
TLS3_k127_7805852_0	313594.PI23P_00225	1.041e-35	138.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,4NF98@976|Bacteroidetes,1I0RT@117743|Flavobacteriia,3VW0P@52959|Polaribacter	976|Bacteroidetes	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
TLS3_k127_7808105_0	1379281.AVAG01000090_gene315	2.541e-124	411.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,2M8F8@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
TLS3_k127_7808105_1	929703.KE386491_gene1246	1.397e-98	332.0	COG3239@1|root,COG3239@2|Bacteria,4NH2H@976|Bacteroidetes,47K2X@768503|Cytophagia	976|Bacteroidetes	I	Sphingolipid Delta4-desaturase (DES)	-	-	1.14.18.5,1.14.19.17	ko:K04712	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00094,M00099	R06519	RC00824	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_desaturase,Lipid_DES
TLS3_k127_7819959_0	1121896.JMLU01000019_gene821	2.751e-91	307.0	COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,1HX1P@117743|Flavobacteriia,2NS8H@237|Flavobacterium	976|Bacteroidetes	S	in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
TLS3_k127_7819959_1	1123368.AUIS01000006_gene583	3.298e-50	184.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
TLS3_k127_7830572_0	1454004.AW11_00130	7.27e-148	473.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KPQU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	JKL	Belongs to the DEAD box helicase family	rhlE1	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS3_k127_7853567_1	1042209.HK44_000550	2.09e-05	51.0	COG1306@1|root,COG1306@2|Bacteria,1MWBY@1224|Proteobacteria,1RV3Z@1236|Gammaproteobacteria,1YTA5@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
TLS3_k127_7853567_0	744872.Spica_0012	9.314e-46	174.0	COG0313@1|root,COG0313@2|Bacteria,2J5DW@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS3_k127_7853602_1	479435.Kfla_6037	4.255e-14	78.0	COG0454@1|root,COG0456@2|Bacteria,2HZJR@201174|Actinobacteria,4DS7Z@85009|Propionibacteriales	201174|Actinobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS3_k127_7853602_0	278957.ABEA03000180_gene2022	6.548e-47	174.0	COG0740@1|root,COG0740@2|Bacteria,46TSB@74201|Verrucomicrobia,3K79J@414999|Opitutae	414999|Opitutae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
TLS3_k127_7857709_0	522772.Dacet_0050	8.61e-53	196.0	COG0697@1|root,COG0697@2|Bacteria,2GGBX@200930|Deferribacteres	200930|Deferribacteres	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_7858289_0	330214.NIDE3851	1.93e-174	559.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS3_k127_7859157_0	1047013.AQSP01000123_gene1545	7.008e-29	134.0	COG2373@1|root,COG2373@2|Bacteria,2NQA2@2323|unclassified Bacteria	2|Bacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
TLS3_k127_786410_1	545695.TREAZ_2242	1.294e-05	58.0	2F00C@1|root,33T4C@2|Bacteria,2J5MS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_786410_0	1121897.AUGO01000003_gene1761	1.477e-36	149.0	COG0616@1|root,COG0616@2|Bacteria,4NES1@976|Bacteroidetes,1HWJS@117743|Flavobacteriia,2NTJQ@237|Flavobacterium	976|Bacteroidetes	OU	signal peptide peptidase SppA, 67K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS3_k127_7866513_3	1121920.AUAU01000030_gene2717	6.912e-08	61.0	COG0775@1|root,COG0775@2|Bacteria	2|Bacteria	F	adenosylhomocysteine nucleosidase activity	mqnB	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.4.2.1,3.2.2.26,3.2.2.9	ko:K01243,ko:K03784,ko:K11783	ko00130,ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,ko01230,map00130,map00230,map00240,map00270,map00760,map01100,map01110,map01230	M00034,M00609	R00194,R01401,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R08587,R10244	RC00033,RC00063,RC00122,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS3_k127_7866513_1	929562.Emtol_3737	1.015e-59	216.0	COG1738@1|root,COG1738@2|Bacteria,4NFP3@976|Bacteroidetes,47J8X@768503|Cytophagia	976|Bacteroidetes	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
TLS3_k127_7866513_2	948106.AWZT01000059_gene3418	4.023e-24	115.0	2ACTP@1|root,312EI@2|Bacteria,1RFTU@1224|Proteobacteria,2W0F8@28216|Betaproteobacteria,1K22P@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7866513_0	1089547.KB913013_gene2768	4.045e-68	245.0	COG2017@1|root,COG2017@2|Bacteria,4NE32@976|Bacteroidetes,47KZH@768503|Cytophagia	976|Bacteroidetes	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7867858_0	1283287.KB822585_gene2722	8.014e-40	151.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4DR4B@85009|Propionibacteriales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
TLS3_k127_7867858_1	864051.BurJ1DRAFT_4625	5.348e-29	124.0	COG0625@1|root,COG0625@2|Bacteria,1RAP2@1224|Proteobacteria,2VQGV@28216|Betaproteobacteria,1KN5R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS3_k127_7867858_2	1121935.AQXX01000129_gene1755	2.649e-21	99.0	COG2267@1|root,COG2267@2|Bacteria,1QU2V@1224|Proteobacteria,1T1NP@1236|Gammaproteobacteria,1XRW9@135619|Oceanospirillales	135619|Oceanospirillales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_7869040_0	679197.HMPREF9336_00640	3.702e-77	264.0	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE20	-	1.3.8.7,1.3.8.8	ko:K00249,ko:K00255	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_7885164_1	1265505.ATUG01000001_gene3055	3.909e-69	253.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,2MP6J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
TLS3_k127_7885164_3	1123508.JH636439_gene1524	0.0008324	47.0	COG1918@1|root,COG1918@2|Bacteria,2J0K6@203682|Planctomycetes	203682|Planctomycetes	P	COG1918 Fe2 transport system protein A	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
TLS3_k127_7885164_0	661478.OP10G_4242	2.533e-174	568.0	COG0370@1|root,COG0370@2|Bacteria	2|Bacteria	P	ferrous iron transmembrane transporter activity	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
TLS3_k127_7885164_2	56110.Oscil6304_0567	1.562e-16	90.0	COG2114@1|root,COG2114@2|Bacteria,1G2PF@1117|Cyanobacteria,1H9X1@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_7889580_0	694427.Palpr_2665	1.639e-264	829.0	COG2216@1|root,COG2216@2|Bacteria,4NFBI@976|Bacteroidetes,2FND6@200643|Bacteroidia,22VUY@171551|Porphyromonadaceae	976|Bacteroidetes	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
TLS3_k127_7889580_1	694427.Palpr_2664	5.667e-213	675.0	COG2060@1|root,COG2060@2|Bacteria,4NF2G@976|Bacteroidetes,2FP4S@200643|Bacteroidia,22WF2@171551|Porphyromonadaceae	976|Bacteroidetes	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
TLS3_k127_7889580_2	472759.Nhal_0042	8.514e-07	52.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
TLS3_k127_7890439_0	1125701.HMPREF1221_00388	4.731e-36	152.0	COG4372@1|root,COG4372@2|Bacteria,2J5RI@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Borrelia P83 100 protein	-	-	-	-	-	-	-	-	-	-	-	-	Borrelia_P83
TLS3_k127_7904097_0	665571.STHERM_c11280	4.518e-20	98.0	2C2MH@1|root,33D2Y@2|Bacteria,2J70Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7904097_2	1121937.AUHJ01000004_gene1117	1.026e-09	71.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,4669T@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	membrane	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS3_k127_7904097_1	1157708.KB907454_gene3103	1.15e-11	77.0	COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,2VMQ1@28216|Betaproteobacteria,4AEMT@80864|Comamonadaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
TLS3_k127_7924508_1	1123248.KB893326_gene1376	3.167e-05	49.0	2C9DJ@1|root,33GUH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
TLS3_k127_7924508_0	411459.RUMOBE_03690	2.211e-53	196.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,3XYWD@572511|Blautia	186801|Clostridia	F	Psort location Cytoplasmic, score 8.87	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS3_k127_7924762_0	880073.Calab_2574	1.219e-150	482.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_7924762_2	1499967.BAYZ01000193_gene3902	2.413e-35	149.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
TLS3_k127_7924762_1	1123377.AUIV01000009_gene2575	3.445e-38	149.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1X77M@135614|Xanthomonadales	135614|Xanthomonadales	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	HIT
TLS3_k127_7924762_3	866895.HBHAL_4167	3.85e-13	76.0	COG0546@1|root,COG0546@2|Bacteria,1V6BF@1239|Firmicutes,4HC3F@91061|Bacilli,3NETF@45667|Halobacillus	91061|Bacilli	S	haloacid dehalogenase-like hydrolase	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
TLS3_k127_7932628_0	1267533.KB906734_gene4071	1.366e-37	151.0	COG1090@1|root,COG1090@2|Bacteria,3Y4IA@57723|Acidobacteria,2JKY0@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS3_k127_7932628_2	317025.Tcr_1706	2.088e-27	117.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,461B8@72273|Thiotrichales	72273|Thiotrichales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS3_k127_7932628_3	1177928.TH2_14857	1.184e-19	95.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,2JTBZ@204441|Rhodospirillales	204441|Rhodospirillales	T	Phosphohistidine phosphatase SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS3_k127_7932628_1	1105031.HMPREF1141_3535	3.986e-36	141.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,36E3S@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS3_k127_793981_0	570952.ATVH01000013_gene2656	1.303e-29	120.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,2JPZD@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS3_k127_793981_1	891968.Anamo_0882	3.626e-14	76.0	COG0771@1|root,COG0771@2|Bacteria,3TAK4@508458|Synergistetes	508458|Synergistetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS3_k127_7941927_2	1121957.ATVL01000006_gene2586	4.463e-10	62.0	COG2197@1|root,COG2197@2|Bacteria,4NMX5@976|Bacteroidetes,47PYR@768503|Cytophagia	976|Bacteroidetes	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_7941927_0	582744.Msip34_0810	8.72e-33	130.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2VSDT@28216|Betaproteobacteria,2KMTB@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS3_k127_7941927_1	1123242.JH636435_gene934	1.448e-32	136.0	COG2202@1|root,COG4585@1|root,COG5000@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,COG5000@2|Bacteria,2J0U8@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3
TLS3_k127_7955215_0	373903.Hore_16210	1.794e-77	277.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS3_k127_7962512_1	1410609.JHVB01000001_gene1786	4.852e-90	307.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS3_k127_7962512_0	1209989.TepiRe1_0309	2.532e-133	440.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,42FBS@68295|Thermoanaerobacterales	186801|Clostridia	JKL	PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
TLS3_k127_7962512_3	32049.SYNPCC7002_A0909	1.549e-13	70.0	COG2954@1|root,COG2954@2|Bacteria,1G5NQ@1117|Cyanobacteria,1H05R@1129|Synechococcus	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
TLS3_k127_7962512_2	509191.AEDB02000094_gene4210	1.557e-30	124.0	COG5418@1|root,COG5418@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
TLS3_k127_7967016_2	909663.KI867150_gene1849	3.007e-14	78.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WQQK@28221|Deltaproteobacteria,2MQMY@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
TLS3_k127_7967016_0	228410.NE1847	2.277e-66	249.0	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,2WB7N@28216|Betaproteobacteria,372HS@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS3_k127_7967016_3	1123389.ATXJ01000049_gene1653	9.244e-07	56.0	2DRHM@1|root,33799@2|Bacteria,1WKGG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7967016_1	658612.MD26_16850	7.658e-42	160.0	COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,1S3A0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_7969408_1	1123354.AUDR01000013_gene730	5.473e-08	53.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2VI10@28216|Betaproteobacteria,1KRMQ@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS3_k127_7969408_2	1278073.MYSTI_00730	5.681e-07	59.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WNRN@28221|Deltaproteobacteria,2YW8K@29|Myxococcales	28221|Deltaproteobacteria	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TLS3_k127_7969408_3	357808.RoseRS_3927	9.989e-07	58.0	2AYXV@1|root,31R3M@2|Bacteria,2GBPM@200795|Chloroflexi,375U4@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7969408_0	331678.Cphamn1_2462	8.727e-31	135.0	COG0860@1|root,COG0860@2|Bacteria,1FD6H@1090|Chlorobi	1090|Chlorobi	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
TLS3_k127_7969803_0	1242864.D187_009245	1.397e-295	920.0	COG2133@1|root,COG2133@2|Bacteria,1QTS4@1224|Proteobacteria	1224|Proteobacteria	G	Neutral/alkaline non-lysosomal ceramidase, C-terminal	-	-	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk,Ceramidse_alk_C
TLS3_k127_7969803_1	867900.Celly_1756	5.219e-62	216.0	COG5646@1|root,COG5646@2|Bacteria,4NNPA@976|Bacteroidetes,1I1Y8@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_7972778_0	261292.Nit79A3_1298	9.164e-30	121.0	COG0425@1|root,COG0425@2|Bacteria,1R8DP@1224|Proteobacteria,2WFJB@28216|Betaproteobacteria,373Y3@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	AurF
TLS3_k127_7972778_1	485918.Cpin_6438	2.485e-18	95.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1IPCA@117747|Sphingobacteriia	976|Bacteroidetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_7972778_2	1458462.JNLK01000001_gene504	1.788e-07	62.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,27JID@186928|unclassified Lachnospiraceae	186801|Clostridia	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,SpoIIE
TLS3_k127_7974767_2	1121904.ARBP01000001_gene5919	2.753e-21	95.0	COG0526@1|root,COG0526@2|Bacteria,4PKQI@976|Bacteroidetes,47XZ0@768503|Cytophagia	976|Bacteroidetes	O	Thioredoxin-like domain	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS3_k127_7974767_0	395493.BegalDRAFT_2112	1.549e-48	183.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1S6AG@1236|Gammaproteobacteria,462B4@72273|Thiotrichales	72273|Thiotrichales	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
TLS3_k127_7974767_1	247634.GPB2148_930	1.104e-24	106.0	COG5331@1|root,COG5331@2|Bacteria,1N7DJ@1224|Proteobacteria,1SGUP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
TLS3_k127_7989995_0	1283300.ATXB01000001_gene1205	1.898e-14	78.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,1XEE8@135618|Methylococcales	135618|Methylococcales	C	NADH dehydrogenase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS3_k127_799234_0	1408428.JNJP01000009_gene1397	1.718e-59	217.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK05@28221|Deltaproteobacteria,2MG50@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
TLS3_k127_799234_1	478741.JAFS01000002_gene551	2.064e-25	109.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46SVA@74201|Verrucomicrobia,37FY0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_7995588_0	351160.RCIX562	0.0002972	50.0	arCOG03561@1|root,arCOG03561@2157|Archaea	2157|Archaea	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7999292_0	1242864.D187_005734	4.032e-153	492.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,42QPP@68525|delta/epsilon subdivisions,2WK2U@28221|Deltaproteobacteria,2YTUH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_7999292_1	1242864.D187_005732	4.45e-77	263.0	COG0702@1|root,COG0702@2|Bacteria,1QR3E@1224|Proteobacteria,4341F@68525|delta/epsilon subdivisions,2X4MP@28221|Deltaproteobacteria,2YZ9G@29|Myxococcales	28221|Deltaproteobacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_7999292_2	744872.Spica_1637	8.322e-33	139.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
TLS3_k127_800260_1	1121396.KB893081_gene1736	3.586e-37	148.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2MIUK@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS3_k127_800260_0	236097.ADG881_2849	4.52e-43	167.0	COG0300@1|root,COG0300@2|Bacteria,1NUXK@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_8011455_0	906968.Trebr_0196	1.582e-58	220.0	COG0004@1|root,COG0643@1|root,COG0004@2|Bacteria,COG0643@2|Bacteria,2JA63@203691|Spirochaetes	203691|Spirochaetes	NPT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,HATPase_c,Hpt
TLS3_k127_8012302_1	1410609.JHVB01000004_gene511	0.0001208	53.0	COG1196@1|root,COG1196@2|Bacteria,2J5RV@203691|Spirochaetes	203691|Spirochaetes	D	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,HTH_38
TLS3_k127_8012302_0	194439.CT1575	2.553e-142	475.0	COG1200@1|root,COG1200@2|Bacteria,1FDNZ@1090|Chlorobi	1090|Chlorobi	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS3_k127_8015755_3	395961.Cyan7425_2656	7.02e-26	109.0	COG0412@1|root,COG0412@2|Bacteria,1G1CY@1117|Cyanobacteria,3KJU9@43988|Cyanothece	1117|Cyanobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS3_k127_8015755_1	118173.KB235914_gene4089	5.506e-56	202.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,1H9WZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
TLS3_k127_8015755_0	272560.BPSL2175	9.365e-72	247.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2VR4K@28216|Betaproteobacteria,1K18T@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the glutathione peroxidase family	gpo	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TLS3_k127_8015755_2	1121127.JAFA01000065_gene4735	3.602e-34	141.0	COG1024@1|root,COG1024@2|Bacteria,1MWXK@1224|Proteobacteria,2W01A@28216|Betaproteobacteria,1K31B@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_8015755_5	373903.Hore_21670	2.049e-13	81.0	COG3858@1|root,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia	186801|Clostridia	M	family 18	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Glyco_hydro_18
TLS3_k127_8024477_0	1379698.RBG1_1C00001G0971	2.339e-84	288.0	COG0152@1|root,COG0152@2|Bacteria,2NP0V@2323|unclassified Bacteria	2|Bacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945,ko:K03566	ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	SAICAR_synt
TLS3_k127_8024477_1	1267535.KB906767_gene3799	2.741e-29	126.0	COG0852@1|root,COG0852@2|Bacteria,3Y5E8@57723|Acidobacteria,2JNBQ@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS3_k127_8030759_0	59374.Fisuc_0005	1.546e-06	60.0	COG3103@1|root,COG3103@2|Bacteria	2|Bacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8033224_2	1296990.H845_2130	9.878e-06	53.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JUYE@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
TLS3_k127_8033224_0	1279009.ADICEAN_00317	1.356e-104	347.0	COG0463@1|root,COG0463@2|Bacteria,4NEZP@976|Bacteroidetes,47MB5@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_4
TLS3_k127_803365_0	1501230.ET33_15115	5.951e-49	188.0	COG1680@1|root,COG1680@2|Bacteria,1UX4S@1239|Firmicutes,4I381@91061|Bacilli,26Z2G@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_8033928_0	945713.IALB_2994	1.148e-06	61.0	28P4Q@1|root,2ZBZV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8039687_0	1121405.dsmv_2528	1.629e-71	256.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,42MQ1@68525|delta/epsilon subdivisions,2WJII@28221|Deltaproteobacteria,2MHPJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
TLS3_k127_8043862_0	1353529.M899_2889	1.08e-57	210.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2MT1V@213481|Bdellovibrionales,2WMSN@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TLS3_k127_8043862_1	59374.Fisuc_2423	1.049e-50	191.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_8044432_0	349521.HCH_04239	1.302e-38	151.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1XM3D@135619|Oceanospirillales	135619|Oceanospirillales	S	Peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
TLS3_k127_8046739_2	661478.OP10G_2742	7.527e-29	128.0	COG0595@1|root,COG0595@2|Bacteria	2|Bacteria	H	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
TLS3_k127_8046739_0	262724.TT_C1079	4.053e-95	318.0	COG0107@1|root,COG0107@2|Bacteria,1WJ30@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS3_k127_8046739_3	616991.JPOO01000001_gene4601	9.513e-26	113.0	COG5580@1|root,COG5580@2|Bacteria,4PK53@976|Bacteroidetes,1I3SX@117743|Flavobacteriia	976|Bacteroidetes	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_8046739_1	1408813.AYMG01000039_gene2245	2.979e-50	186.0	COG3000@1|root,COG3000@2|Bacteria,4NFWX@976|Bacteroidetes,1IXQU@117747|Sphingobacteriia	976|Bacteroidetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_8048324_1	272559.BF9343_1818	6.024e-18	89.0	2CHU7@1|root,2ZHJ4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8048324_2	1121422.AUMW01000020_gene1762	1.345e-12	75.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS3_k127_8048324_0	1313421.JHBV01000035_gene2496	6.672e-72	253.0	COG3239@1|root,COG3239@2|Bacteria,4P03Y@976|Bacteroidetes	976|Bacteroidetes	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS3_k127_8061588_1	1121468.AUBR01000001_gene505	3.827e-54	210.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,42EMA@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS3_k127_8061588_0	665571.STHERM_c10880	5.666e-86	307.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TLS3_k127_8061588_3	537007.BLAHAN_04748	2.308e-08	63.0	COG2891@1|root,COG2891@2|Bacteria,1V1EJ@1239|Firmicutes,24GF4@186801|Clostridia,3Y080@572511|Blautia	186801|Clostridia	M	Psort location CytoplasmicMembrane, score 9.99	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
TLS3_k127_8061588_2	706587.Desti_3716	1.792e-25	119.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2MQK3@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TLS3_k127_8069493_1	768710.DesyoDRAFT_3463	2.387e-38	148.0	COG0745@1|root,COG0745@2|Bacteria,1UDAQ@1239|Firmicutes,249RQ@186801|Clostridia,2622R@186807|Peptococcaceae	186801|Clostridia	KT	PFAM Response regulator receiver domain	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_8069493_0	1156937.MFUM_230013	1.874e-78	275.0	COG0642@1|root,COG2205@2|Bacteria,46UHY@74201|Verrucomicrobia,37GB8@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	Osmosensitive K+ channel His kinase sensor domain	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
TLS3_k127_8071874_2	439235.Dalk_4148	3.717e-38	146.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WUG9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_8071874_0	1122164.JHWF01000003_gene2136	1.99e-85	295.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1JCWT@118969|Legionellales	118969|Legionellales	I	Fatty acid desaturase	-	-	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
TLS3_k127_8071874_1	880073.Calab_3038	7.647e-66	234.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS3_k127_8076655_1	243276.TPANIC_0220	1.551e-07	58.0	COG1366@1|root,COG1366@2|Bacteria,2J8N5@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_8076655_0	5762.XP_002681812.1	5.427e-13	75.0	COG0170@1|root,KOG4453@2759|Eukaryota	2759|Eukaryota	I	phytol kinase activity	DGK1	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576	2.7.1.174	ko:K16368	ko00564,ko01100,ko01110,map00564,map01100,map01110	-	R09944	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP_transf_1
TLS3_k127_8077094_0	1507.HMPREF0262_01943	9.888e-10	59.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,36DUP@31979|Clostridiaceae	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS3_k127_8092761_0	83406.HDN1F_36680	8.788e-105	349.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1SK7D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
TLS3_k127_8092761_1	1095769.CAHF01000022_gene198	2.869e-24	108.0	COG4891@1|root,COG4891@2|Bacteria,1N4U1@1224|Proteobacteria,2VTZI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_8092761_2	1131269.AQVV01000003_gene675	3.119e-11	71.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8103737_1	760192.Halhy_0902	2.011e-19	89.0	COG2270@1|root,COG2270@2|Bacteria,4PKPY@976|Bacteroidetes	976|Bacteroidetes	S	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS3_k127_8103737_3	90814.KL370891_gene1335	6.079e-06	59.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales	72273|Thiotrichales	M	PFAM AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
TLS3_k127_8103737_2	1157708.KB907451_gene4758	5.772e-10	64.0	2EGTE@1|root,33AJI@2|Bacteria,1NM7R@1224|Proteobacteria	1224|Proteobacteria	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
TLS3_k127_8103737_0	204669.Acid345_0108	5.946e-42	174.0	COG1656@1|root,COG1656@2|Bacteria,3Y4NR@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4178
TLS3_k127_8107501_4	794903.OPIT5_13785	4.244e-06	53.0	COG1487@1|root,COG1487@2|Bacteria	794903.OPIT5_13785|-	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8107501_2	665571.STHERM_c09290	5.053e-65	239.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TLS3_k127_8107501_0	118005.AWNK01000006_gene1192	7.188e-161	530.0	COG1298@1|root,COG1298@2|Bacteria	2|Bacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TLS3_k127_8107501_3	272562.CA_C2146	1.139e-35	151.0	COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia,36EPY@31979|Clostridiaceae	186801|Clostridia	N	flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
TLS3_k127_8107501_1	889378.Spiaf_2083	2.381e-78	269.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
TLS3_k127_8109256_0	1218084.BBJK01000212_gene8163	0.0	1037.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K1NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aconitate hydratase	acnD	-	4.2.1.117,4.2.1.3	ko:K01681,ko:K20455	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900,R11263	RC00497,RC00498,RC00618,RC01152	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS3_k127_8109256_1	1123070.KB899251_gene803	5.226e-45	169.0	COG2940@1|root,COG2940@2|Bacteria,46W0B@74201|Verrucomicrobia,2IUGA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	-	-	-	-	-	-	-	-	-	SET
TLS3_k127_810968_0	1046714.AMRX01000006_gene2663	3.947e-74	259.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,465J0@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_810968_1	1313304.CALK_1619	3.355e-41	162.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	gldF	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
TLS3_k127_8111277_0	330214.NIDE1512	7.229e-24	113.0	COG4589@1|root,COG4589@2|Bacteria,3J1FV@40117|Nitrospirae	40117|Nitrospirae	I	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS3_k127_8129275_0	1206720.BAFQ01000005_gene60	1.285e-151	494.0	COG0326@1|root,COG0326@2|Bacteria,2GNPQ@201174|Actinobacteria,4FV89@85025|Nocardiaceae	201174|Actinobacteria	O	Molecular chaperone. Has ATPase activity	htpG	GO:0000302,GO:0000303,GO:0000305,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0010035,GO:0016020,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
TLS3_k127_8135725_2	62928.azo1411	1.573e-15	77.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KUCG@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
TLS3_k127_8135725_1	1120953.AUBH01000007_gene1824	1.259e-31	129.0	COG1406@1|root,COG1406@2|Bacteria,1RATZ@1224|Proteobacteria,1S22M@1236|Gammaproteobacteria,466Q2@72275|Alteromonadaceae	1236|Gammaproteobacteria	N	inhibitor of MCP methylation, homolog of CheC	cheX	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
TLS3_k127_8150719_1	536227.CcarbDRAFT_5441	0.0002295	53.0	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,36DDY@31979|Clostridiaceae	186801|Clostridia	O	peptidylprolyl isomerase	prsA2	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
TLS3_k127_8150719_0	717774.Marme_3023	4.53e-34	136.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1XK83@135619|Oceanospirillales	135619|Oceanospirillales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
TLS3_k127_8155331_0	397291.C804_02831	2.124e-71	246.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,27JCF@186928|unclassified Lachnospiraceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS3_k127_8183754_0	686340.Metal_1961	2.926e-185	607.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1XE61@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
TLS3_k127_8183754_1	1116472.MGMO_100c00020	1.524e-114	391.0	COG1009@1|root,COG1009@2|Bacteria,1R5G2@1224|Proteobacteria,1RN3G@1236|Gammaproteobacteria,1XDPZ@135618|Methylococcales	135618|Methylococcales	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
TLS3_k127_8183754_2	857087.Metme_1587	9.35e-60	213.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1XDZX@135618|Methylococcales	135618|Methylococcales	P	PFAM Sulphate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TLS3_k127_819998_1	313603.FB2170_16751	8.954e-33	132.0	COG3239@1|root,COG3239@2|Bacteria,4NERD@976|Bacteroidetes,1HX6Z@117743|Flavobacteriia,2PGWQ@252356|Maribacter	976|Bacteroidetes	I	Fatty acid desaturase	-	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS3_k127_819998_0	368407.Memar_0380	1.008e-38	153.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
TLS3_k127_8203832_0	931276.Cspa_c20080	7.223e-58	224.0	COG2247@1|root,COG3291@1|root,COG4447@1|root,COG4932@1|root,COG5263@1|root,COG2247@2|Bacteria,COG3291@2|Bacteria,COG4447@2|Bacteria,COG4932@2|Bacteria,COG5263@2|Bacteria,1VCI4@1239|Firmicutes,24CF6@186801|Clostridia,36N4E@31979|Clostridiaceae	186801|Clostridia	M	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,N_methyl
TLS3_k127_8206192_0	697303.Thewi_1720	2.78e-155	512.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS3_k127_8206192_2	357808.RoseRS_3609	2.96e-80	278.0	COG0530@1|root,COG0530@2|Bacteria,2G7I2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS3_k127_8206192_1	700598.Niako_3481	1.083e-125	420.0	COG0659@1|root,COG0659@2|Bacteria,4NE9G@976|Bacteroidetes,1INYY@117747|Sphingobacteriia	976|Bacteroidetes	P	COGs COG0659 Sulfate permease and related transporter (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TLS3_k127_8206192_3	700598.Niako_3481	1.309e-79	276.0	COG0659@1|root,COG0659@2|Bacteria,4NE9G@976|Bacteroidetes,1INYY@117747|Sphingobacteriia	976|Bacteroidetes	P	COGs COG0659 Sulfate permease and related transporter (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
TLS3_k127_8207028_0	511.JT27_07485	5.741e-37	154.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2WGJ7@28216|Betaproteobacteria,3T9HQ@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
TLS3_k127_8207028_1	1123242.JH636434_gene4554	3.054e-30	132.0	COG4249@1|root,COG4249@2|Bacteria,2J2RG@203682|Planctomycetes	203682|Planctomycetes	S	Agenet domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
TLS3_k127_8212046_0	1124780.ANNU01000005_gene2378	4.633e-34	137.0	COG0596@1|root,COG0596@2|Bacteria,4NDZI@976|Bacteroidetes,47JB4@768503|Cytophagia	976|Bacteroidetes	S	Serine aminopeptidase, S33	ybfF	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_8212046_1	429009.Adeg_1622	1.276e-06	57.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,42FI3@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS3_k127_8213661_1	204536.SULAZ_0985	2.05e-94	335.0	COG0128@1|root,COG0128@2|Bacteria,2G3JZ@200783|Aquificae	200783|Aquificae	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS3_k127_8213661_0	1125863.JAFN01000001_gene1660	4.673e-108	369.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS3_k127_8233663_1	1238182.C882_1755	1.966e-29	134.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,2JQ06@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS3_k127_8233663_0	709797.CSIRO_3424	5.317e-71	252.0	COG0614@1|root,COG0614@2|Bacteria,1PK1C@1224|Proteobacteria,2TRF4@28211|Alphaproteobacteria,3JUAC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
TLS3_k127_8233663_2	1184267.A11Q_487	6.801e-10	60.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,42P6R@68525|delta/epsilon subdivisions,2MSMN@213481|Bdellovibrionales,2WKXS@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS3_k127_8234356_2	1294143.H681_08550	9.019e-24	107.0	28MN9@1|root,2ZAXV@2|Bacteria,1PPEY@1224|Proteobacteria,1RYAD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8234356_0	1123393.KB891330_gene782	1.118e-99	338.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1KSC8@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS3_k127_8234356_4	1191523.MROS_0656	8.985e-05	55.0	28P4Q@1|root,2ZBZV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8234356_1	243275.TDE_0205	1.802e-58	217.0	COG2114@1|root,COG2114@2|Bacteria,2J6YU@203691|Spirochaetes	203691|Spirochaetes	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	2TM,Guanylate_cyc
TLS3_k127_8241016_1	330214.NIDE4143	1.575e-25	116.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Spermine_synth
TLS3_k127_8241016_0	489825.LYNGBM3L_24440	8.646e-114	376.0	COG0604@1|root,COG0604@2|Bacteria,1G3SY@1117|Cyanobacteria,1HEBR@1150|Oscillatoriales	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
TLS3_k127_8241016_2	468059.AUHA01000003_gene1685	1.714e-22	97.0	COG2271@1|root,COG2271@2|Bacteria,4NG3R@976|Bacteroidetes,1IW8Q@117747|Sphingobacteriia	976|Bacteroidetes	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
TLS3_k127_8241327_0	351627.Csac_2083	5.349e-89	309.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,42EMV@68295|Thermoanaerobacterales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
TLS3_k127_8241327_1	290397.Adeh_0116	1.059e-31	131.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2YX0Q@29|Myxococcales	28221|Deltaproteobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS3_k127_8242665_0	118163.Ple7327_0865	1.116e-113	379.0	COG1233@1|root,COG1233@2|Bacteria,1G4AK@1117|Cyanobacteria	1117|Cyanobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
TLS3_k127_8242665_1	887898.HMPREF0551_1545	0.0005654	52.0	2A2RR@1|root,30R50@2|Bacteria,1RF6F@1224|Proteobacteria,2VYJ0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alginate export	-	-	-	ko:K16081	-	-	-	-	ko00000,ko02000	1.B.13.1	-	-	Alginate_exp
TLS3_k127_8245050_0	653733.Selin_2418	1.753e-59	217.0	COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	yliE	GO:0003674,GO:0003824,GO:0008081,GO:0016787,GO:0016788,GO:0042578,GO:0071111	-	-	-	-	-	-	-	-	-	-	CHASE9,EAL,GGDEF,Response_reg
TLS3_k127_8245050_1	1026882.MAMP_02828	6.685e-36	143.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
TLS3_k127_825732_1	1286632.P278_13120	5.854e-08	55.0	COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,1HWYD@117743|Flavobacteriia	976|Bacteroidetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_825732_0	1502724.FF80_01519	4.645e-43	165.0	COG1413@1|root,COG1413@2|Bacteria,1MZV0@1224|Proteobacteria,2UERM@28211|Alphaproteobacteria,3N8R0@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8267340_1	56110.Oscil6304_3613	4.534e-85	293.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	BLUF,CHASE2,Guanylate_cyc
TLS3_k127_8267340_0	706587.Desti_4167	1.72e-151	496.0	COG0659@1|root,COG0659@2|Bacteria,1MXA7@1224|Proteobacteria,42ZHY@68525|delta/epsilon subdivisions,2WV08@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	-
TLS3_k127_8273723_1	1280696.ATVY01000019_gene2865	3.348e-47	177.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,4BXI2@830|Butyrivibrio	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS3_k127_8273723_2	1123366.TH3_07075	2.748e-25	109.0	COG0607@1|root,COG0607@2|Bacteria,1Q2JH@1224|Proteobacteria,2UHT3@28211|Alphaproteobacteria,2JUEZ@204441|Rhodospirillales	204441|Rhodospirillales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_8273723_0	879212.DespoDRAFT_02546	1.263e-119	396.0	COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,42ZPX@68525|delta/epsilon subdivisions,2WV2B@28221|Deltaproteobacteria,2MND9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
TLS3_k127_8273723_3	439235.Dalk_3740	0.0001542	50.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	cbrA	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS3_k127_8273935_0	686340.Metal_0292	5.663e-37	156.0	COG0834@1|root,COG3920@1|root,COG4251@1|root,COG0834@2|Bacteria,COG3920@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HWE_HK,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,dCache_1
TLS3_k127_8274668_1	1219031.BBJR01000042_gene2787	2.136e-05	56.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,4AA87@80864|Comamonadaceae	28216|Betaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
TLS3_k127_8274668_0	526224.Bmur_0770	8.971e-32	132.0	COG0193@1|root,COG0193@2|Bacteria,2J8P8@203691|Spirochaetes	203691|Spirochaetes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	ABM,Pept_tRNA_hydro
TLS3_k127_8278920_0	1289135.A966_03383	2.41e-42	170.0	COG0617@1|root,COG0617@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
TLS3_k127_8278920_1	1480694.DC28_00565	2.193e-25	116.0	COG2227@1|root,COG2227@2|Bacteria,2JBIU@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase domain	ubiG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS3_k127_8279198_0	1120978.KB894080_gene1360	9.907e-53	190.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,27FEH@186828|Carnobacteriaceae	91061|Bacilli	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS3_k127_828921_0	1123270.ATUR01000007_gene1342	3.793e-51	192.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria,2K088@204457|Sphingomonadales	204457|Sphingomonadales	Q	Cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_8291897_0	574376.BAMA_13570	1.918e-13	73.0	COG1183@1|root,COG1183@2|Bacteria,1TR44@1239|Firmicutes,4HWWT@91061|Bacilli,1ZRQ5@1386|Bacillus	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
TLS3_k127_8291897_1	1128421.JAGA01000002_gene191	0.0008297	52.0	2EDFC@1|root,3366P@2|Bacteria	2|Bacteria	S	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
TLS3_k127_8304461_1	1144275.COCOR_04186	3.39e-61	220.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42RAD@68525|delta/epsilon subdivisions,2X5RN@28221|Deltaproteobacteria,2Z372@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS3_k127_8304461_3	864051.BurJ1DRAFT_0475	1.242e-19	97.0	2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,2VS4A@28216|Betaproteobacteria,1KKT6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8304461_2	269799.Gmet_2863	2.858e-37	151.0	COG0388@1|root,COG0388@2|Bacteria,1RIQI@1224|Proteobacteria,42T6J@68525|delta/epsilon subdivisions,2WPVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_8304461_0	1379698.RBG1_1C00001G0370	9.601e-85	297.0	COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS3_k127_8305049_0	926550.CLDAP_37080	6.079e-195	614.0	COG0538@1|root,COG0538@2|Bacteria,2G5SM@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
TLS3_k127_8305049_2	8479.XP_005306017.1	3.248e-52	197.0	COG1024@1|root,KOG1680@2759|Eukaryota,38GW7@33154|Opisthokonta,3BEV5@33208|Metazoa,3D05B@33213|Bilateria,487YW@7711|Chordata,4951Z@7742|Vertebrata,4CGPZ@8459|Testudines	33208|Metazoa	I	Belongs to the enoyl-CoA hydratase isomerase family	-	GO:0001666,GO:0003008,GO:0006950,GO:0007600,GO:0008150,GO:0009628,GO:0009987,GO:0019233,GO:0032501,GO:0033554,GO:0036293,GO:0036294,GO:0042221,GO:0050877,GO:0050896,GO:0051716,GO:0070482,GO:0070887,GO:0071453,GO:0071456	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_8305049_1	686340.Metal_0160	1.383e-82	281.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1XEHN@135618|Methylococcales	135618|Methylococcales	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS3_k127_8305493_0	1403819.BATR01000040_gene1181	9.595e-28	128.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,46WM8@74201|Verrucomicrobia,2IV4E@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,TPR_16,Transglut_core
TLS3_k127_8305718_1	9305.ENSSHAP00000002943	7.044e-30	120.0	COG0596@1|root,COG1011@1|root,KOG3085@2759|Eukaryota,KOG4178@2759|Eukaryota,39WAD@33154|Opisthokonta,3BACN@33208|Metazoa,3CVBC@33213|Bilateria,482KF@7711|Chordata,48X7C@7742|Vertebrata,3JII9@40674|Mammalia,4K68M@9263|Metatheria	33208|Metazoa	I	Alpha/beta hydrolase family	EPHX2	GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006633,GO:0006690,GO:0006725,GO:0006793,GO:0006796,GO:0006805,GO:0006810,GO:0006873,GO:0006874,GO:0006875,GO:0006886,GO:0006950,GO:0006952,GO:0006954,GO:0006996,GO:0007031,GO:0007600,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008217,GO:0008610,GO:0009056,GO:0009058,GO:0009410,GO:0009636,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015031,GO:0015643,GO:0015833,GO:0016043,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0017144,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019369,GO:0019373,GO:0019439,GO:0019725,GO:0019752,GO:0030003,GO:0030258,GO:0031907,GO:0031974,GO:0032501,GO:0032787,GO:0033036,GO:0033365,GO:0033559,GO:0034613,GO:0035150,GO:0035296,GO:0042221,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042759,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045777,GO:0046272,GO:0046394,GO:0046483,GO:0046839,GO:0046872,GO:0046907,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0050877,GO:0050880,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070727,GO:0070887,GO:0071466,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072330,GO:0072503,GO:0072507,GO:0072593,GO:0072594,GO:0072662,GO:0072663,GO:0080090,GO:0090066,GO:0090181,GO:0097176,GO:0097746,GO:0097755,GO:0098771,GO:1900673,GO:1901360,GO:1901361,GO:1901568,GO:1901575,GO:1901576	3.1.3.76,3.3.2.10	ko:K08726,ko:K10089	ko00590,ko00625,ko01100,ko01120,ko04142,ko04145,ko04146,map00590,map00625,map01100,map01120,map04142,map04145,map04146	-	R05842,R07108,R07109,R07110,R07111	RC01477,RC01757	ko00000,ko00001,ko01000,ko01002,ko01009,ko04091,ko04147	-	-	-	Abhydrolase_1,HAD_2
TLS3_k127_8305718_2	1121035.AUCH01000015_gene2596	5.024e-21	99.0	COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,2VT8G@28216|Betaproteobacteria,2KWR8@206389|Rhodocyclales	206389|Rhodocyclales	P	Hemerythrin-like metal-binding protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
TLS3_k127_8305718_0	655815.ZPR_4697	6.524e-44	175.0	COG4299@1|root,COG4299@2|Bacteria,4NDZF@976|Bacteroidetes,1HX1B@117743|Flavobacteriia	976|Bacteroidetes	S	COGs COG4299 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
TLS3_k127_8310762_1	273068.TTE2235	1.291e-81	279.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,42F0K@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	-	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7	ko:K00868,ko:K00941,ko:K14153	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS3_k127_8310762_0	247490.KSU1_C0602	2.944e-86	299.0	COG2133@1|root,COG2133@2|Bacteria,2IXAF@203682|Planctomycetes	203682|Planctomycetes	G	glucose sorbosone	-	-	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	DUF1080,GSDH,SGL
TLS3_k127_8311080_0	656519.Halsa_1998	2.273e-14	78.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,3WC19@53433|Halanaerobiales	186801|Clostridia	D	Belongs to the SpoVG family	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
TLS3_k127_8311080_1	714961.BFZC1_13208	2.563e-13	78.0	COG3714@1|root,COG3714@2|Bacteria,1V3FV@1239|Firmicutes,4HHMP@91061|Bacilli,3IWNJ@400634|Lysinibacillus	91061|Bacilli	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
TLS3_k127_8316441_0	240016.ABIZ01000001_gene1216	4.829e-150	488.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_8,Response_reg
TLS3_k127_8316441_2	1121445.ATUZ01000011_gene626	2.51e-15	80.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_8316441_1	744872.Spica_2526	1.623e-28	121.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2JBDH@203691|Spirochaetes	2|Bacteria	KT	7TM diverse intracellular signalling	rsbW	-	2.4.1.12,3.1.3.3	ko:K00694,ko:K07315,ko:K20977	ko00500,ko01100,ko02020,ko02025,ko02026,map00500,map01100,map02020,map02025,map02026	M00820	R02889	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02022,ko03021	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	HATPase_c_2,MatE,SpoIIE
TLS3_k127_8323569_7	517418.Ctha_1929	4.36e-06	52.0	COG1366@1|root,COG1366@2|Bacteria,1FEAD@1090|Chlorobi	1090|Chlorobi	T	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS
TLS3_k127_8323569_0	1121887.AUDK01000005_gene3163	3.71e-134	444.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,N6_Mtase,TaqI_C
TLS3_k127_8323569_2	1298593.TOL_1706	7.42e-85	296.0	COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,1RYUQ@1236|Gammaproteobacteria,1XI8G@135619|Oceanospirillales	135619|Oceanospirillales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8323569_4	1123248.KB893315_gene3111	1.873e-32	130.0	COG0640@1|root,COG0640@2|Bacteria,4NQK3@976|Bacteroidetes,1IYKS@117747|Sphingobacteriia	976|Bacteroidetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
TLS3_k127_8323569_3	1313301.AUGC01000003_gene2135	6.272e-37	148.0	COG0500@1|root,COG0500@2|Bacteria,4NPKT@976|Bacteroidetes	976|Bacteroidetes	Q	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
TLS3_k127_8323569_1	1121889.AUDM01000006_gene1500	6.964e-129	419.0	COG0701@1|root,COG0701@2|Bacteria,4NDUJ@976|Bacteroidetes,1HX91@117743|Flavobacteriia,2NV6C@237|Flavobacterium	976|Bacteroidetes	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
TLS3_k127_8323569_5	931626.Awo_c04600	3.606e-20	92.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,25ZA4@186806|Eubacteriaceae	186801|Clostridia	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
TLS3_k127_8323569_6	929556.Solca_3636	4.601e-17	81.0	COG0798@1|root,COG0798@2|Bacteria,4NFG7@976|Bacteroidetes,1IP3I@117747|Sphingobacteriia	976|Bacteroidetes	P	arsenical-resistance protein	acr3	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS3_k127_8324959_1	644282.Deba_2330	1.148e-22	98.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2WJDN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Belongs to the flagella basal body rod proteins family	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS3_k127_8324959_0	1379281.AVAG01000057_gene413	1.733e-29	126.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2WK22@28221|Deltaproteobacteria,2M7UP@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
TLS3_k127_8327241_0	468059.AUHA01000003_gene1806	4.548e-76	267.0	COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,1IPNC@117747|Sphingobacteriia	976|Bacteroidetes	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS3_k127_8328010_0	404589.Anae109_2973	6.624e-154	499.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,42NHS@68525|delta/epsilon subdivisions,2WJHI@28221|Deltaproteobacteria,2YU3U@29|Myxococcales	28221|Deltaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS3_k127_8328010_1	1379270.AUXF01000002_gene1438	3.884e-25	108.0	COG3288@1|root,COG3288@2|Bacteria,1ZV3E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
TLS3_k127_8328642_1	1340493.JNIF01000003_gene3716	1.038e-09	70.0	COG4783@1|root,COG4783@2|Bacteria,3Y8U1@57723|Acidobacteria	57723|Acidobacteria	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8328642_0	926549.KI421517_gene455	2.172e-75	263.0	COG2234@1|root,COG2234@2|Bacteria,4NIQX@976|Bacteroidetes,47MWW@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
TLS3_k127_83299_3	1469557.JSWF01000025_gene1455	1.337e-11	65.0	COG3714@1|root,COG3714@2|Bacteria,4NMZ9@976|Bacteroidetes,1I1IJ@117743|Flavobacteriia	976|Bacteroidetes	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
TLS3_k127_83299_0	1179155.CF67_04122	1.117e-104	352.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XSMD@135623|Vibrionales	135623|Vibrionales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS3_k127_83299_2	269799.Gmet_0456	6.278e-13	80.0	COG2227@1|root,COG4641@1|root,COG2227@2|Bacteria,COG4641@2|Bacteria,1RHSX@1224|Proteobacteria	1224|Proteobacteria	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
TLS3_k127_83299_1	944479.JQLX01000011_gene742	9.377e-19	93.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS3_k127_8330292_0	398512.JQKC01000016_gene2751	2.8e-17	91.0	COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia,3WJUP@541000|Ruminococcaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PAP2_3
TLS3_k127_8330292_1	351348.Maqu_2531	3.022e-13	79.0	COG4254@1|root,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,1S1E7@1236|Gammaproteobacteria,46B8N@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
TLS3_k127_8351442_1	1242864.D187_004950	9.967e-29	119.0	COG4894@1|root,COG4894@2|Bacteria,1RKPJ@1224|Proteobacteria,434XW@68525|delta/epsilon subdivisions,2WZ8Q@28221|Deltaproteobacteria,2Z1KE@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8351442_2	882.DVU_1243	4.375e-15	82.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2MAXD@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM toluene tolerance family protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
TLS3_k127_8351442_0	360107.CHAB381_0319	1.839e-29	122.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2YNXT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	(Lipo)protein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
TLS3_k127_8351743_2	1479235.KK366039_gene97	1.614e-10	62.0	COG0515@1|root,COG0515@2|Bacteria,1R7HM@1224|Proteobacteria,1RUIY@1236|Gammaproteobacteria,1XR6D@135619|Oceanospirillales	135619|Oceanospirillales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS3_k127_8351743_0	1089553.Tph_c27390	3.606e-146	471.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,42F4E@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS3_k127_8351743_1	1379270.AUXF01000004_gene3173	1.988e-37	146.0	COG0224@1|root,COG0224@2|Bacteria,1ZSZR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS3_k127_8353035_1	1328313.DS2_01728	6.332e-38	151.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,4645T@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	iYL1228.KPN_03597,ic_1306.c3945	polyprenyl_synt
TLS3_k127_8353035_0	196367.JNFG01000004_gene5412	1.358e-67	241.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2VJ2P@28216|Betaproteobacteria,1K4JY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,HTH_17,SHOCT
TLS3_k127_8354175_1	207954.MED92_13011	5.036e-89	303.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XH59@135619|Oceanospirillales	135619|Oceanospirillales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,PAS_9
TLS3_k127_8354175_0	395494.Galf_0009	3.651e-92	310.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	bclA_1	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_8355475_0	83406.HDN1F_27760	5.423e-92	314.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1J5C4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_8363533_1	744872.Spica_0671	2.2e-21	96.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
TLS3_k127_8363533_0	1267535.KB906767_gene2479	1.694e-42	165.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria,2JI3B@204432|Acidobacteriia	204432|Acidobacteriia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
TLS3_k127_836538_0	237368.SCABRO_02864	4.333e-32	139.0	COG0399@1|root,COG0399@2|Bacteria,2IYUJ@203682|Planctomycetes	203682|Planctomycetes	E	pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
TLS3_k127_8366770_2	880072.Desac_0583	1.996e-08	60.0	COG0811@1|root,COG0811@2|Bacteria,1NBED@1224|Proteobacteria,42WAH@68525|delta/epsilon subdivisions,2X5KM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	MotA TolQ ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TLS3_k127_8366770_1	181119.XP_005534527.1	3.742e-37	151.0	COG0204@1|root,KOG2848@2759|Eukaryota,38GE5@33154|Opisthokonta,3BC07@33208|Metazoa,3CWDI@33213|Bilateria,48837@7711|Chordata,48WN3@7742|Vertebrata,4GW53@8782|Aves	33208|Metazoa	I	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like	AGPAT1	GO:0001817,GO:0001819,GO:0001959,GO:0001961,GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010646,GO:0010647,GO:0012505,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019222,GO:0019637,GO:0023051,GO:0023056,GO:0031323,GO:0031325,GO:0031984,GO:0042171,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0051239,GO:0051240,GO:0060759,GO:0060760,GO:0065007,GO:0071617,GO:0071704,GO:0090407,GO:0098827,GO:1901576	2.3.1.51	ko:K03989,ko:K13509	ko00561,ko00564,ko01100,ko01110,ko04072,ko04610,ko04975,ko05133,ko05150,ko05322,map00561,map00564,map01100,map01110,map04072,map04610,map04975,map05133,map05150,map05322	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	-	-	-	Acyltransferase
TLS3_k127_8366770_0	452637.Oter_1686	8.162e-67	235.0	COG1272@1|root,COG1272@2|Bacteria,46T25@74201|Verrucomicrobia,3K7KU@414999|Opitutae	74201|Verrucomicrobia	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
TLS3_k127_8372_5	638303.Thal_1386	4.074e-16	86.0	COG1463@1|root,COG1463@2|Bacteria,2G3I1@200783|Aquificae	200783|Aquificae	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS3_k127_8372_7	1249480.B649_01520	0.0007228	51.0	COG1463@1|root,COG1463@2|Bacteria,1RFFS@1224|Proteobacteria,42P4P@68525|delta/epsilon subdivisions,2YNNZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS3_k127_8372_6	240015.ACP_2782	6.57e-05	53.0	COG3088@1|root,COG3088@2|Bacteria,3Y4YV@57723|Acidobacteria,2JJM2@204432|Acidobacteriia	204432|Acidobacteriia	O	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS3_k127_8372_1	1304888.ATWF01000001_gene901	7.661e-235	734.0	COG0499@1|root,COG0499@2|Bacteria,2GEPA@200930|Deferribacteres	200930|Deferribacteres	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS3_k127_8372_3	864702.OsccyDRAFT_3843	1.612e-89	312.0	COG1231@1|root,COG1231@2|Bacteria,1G3IC@1117|Cyanobacteria,1H8H3@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS3_k127_8372_4	313612.L8106_16464	3.158e-26	122.0	COG2843@1|root,COG2843@2|Bacteria,1G20Q@1117|Cyanobacteria,1H7BE@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS3_k127_8372_2	697282.Mettu_2660	3.616e-159	522.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF
TLS3_k127_8372_0	768671.ThimaDRAFT_1090	6.895e-315	984.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,1T2RH@1236|Gammaproteobacteria,1WW59@135613|Chromatiales	1236|Gammaproteobacteria	NT	PFAM CheB methylesterase	-	-	-	-	-	-	-	-	-	-	-	-	CheB_methylest,CheR,CheR_N,PAS,PAS_10,PAS_4
TLS3_k127_837650_0	502025.Hoch_3072	6.885e-148	477.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_8380323_1	1519464.HY22_01215	1.764e-26	119.0	COG0705@1|root,COG0705@2|Bacteria,1FDF1@1090|Chlorobi	1090|Chlorobi	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS3_k127_8380323_0	1539298.JO41_03480	4.226e-51	192.0	COG1306@1|root,COG1306@2|Bacteria,2J5BQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
TLS3_k127_8381180_1	1545915.JROG01000009_gene2869	1.827e-27	121.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2K182@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TLS3_k127_8381180_0	1279009.ADICEAN_00552	2.92e-72	248.0	COG0399@1|root,COG0399@2|Bacteria,4NEIU@976|Bacteroidetes,47JAI@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the DegT DnrJ EryC1 family	wecE	-	2.6.1.59	ko:K02805	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	DegT_DnrJ_EryC1
TLS3_k127_8382406_0	273068.TTE0549	4.532e-57	216.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,42EVW@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the thiolase family	thlA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_8383470_0	318161.Sden_1098	3.185e-17	91.0	COG1075@1|root,COG1075@2|Bacteria,1NB6J@1224|Proteobacteria,1RS95@1236|Gammaproteobacteria,2Q9VH@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Lipase (class 2)	hlyC	GO:0003674,GO:0003824,GO:0004806,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0052689,GO:0071704,GO:1901575	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
TLS3_k127_8397527_2	1198114.AciX9_1712	1.27e-26	117.0	COG0704@1|root,COG0704@2|Bacteria,3Y4DI@57723|Acidobacteria,2JJ5M@204432|Acidobacteriia	204432|Acidobacteriia	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS3_k127_8397527_0	338966.Ppro_3160	4.428e-103	341.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,43U4R@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS3_k127_8397527_1	1408422.JHYF01000006_gene1212	1.058e-66	235.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,36DCX@31979|Clostridiaceae	186801|Clostridia	P	Phosphate transport system permease protein PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
TLS3_k127_8405944_1	1254432.SCE1572_17865	1.583e-16	84.0	298PG@1|root,2ZVTY@2|Bacteria,1RIKV@1224|Proteobacteria,433IU@68525|delta/epsilon subdivisions,2WXIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8405944_0	404380.Gbem_2446	8.834e-214	687.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,43U0M@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TLS3_k127_8413093_0	1480694.DC28_02270	5.92e-64	229.0	COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes	203691|Spirochaetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS3_k127_8415088_0	886379.AEWI01000059_gene2768	1.588e-151	482.0	COG0610@1|root,COG0610@2|Bacteria,4NFJ8@976|Bacteroidetes,2FMP6@200643|Bacteroidia,3XKIF@558415|Marinilabiliaceae	976|Bacteroidetes	L	Type I restriction and modification enzyme - subunit R C terminal	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoR124_C,HSDR_N,ResIII
TLS3_k127_8415088_3	1123303.AQVD01000002_gene1748	3.788e-11	67.0	2EKHD@1|root,33E7D@2|Bacteria,1VZXU@1239|Firmicutes,4HXYR@91061|Bacilli	91061|Bacilli	S	STAS-like domain of unknown function (DUF4325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4325
TLS3_k127_8415088_2	907348.TresaDRAFT_0154	1.468e-16	85.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_8415088_1	531844.FIC_00619	2.25e-31	131.0	2A760@1|root,30W1Z@2|Bacteria,4P2EY@976|Bacteroidetes,1I8NH@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8420804_0	1121935.AQXX01000140_gene976	5.067e-58	213.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_8420804_2	1288494.EBAPG3_17270	2.476e-10	67.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VPIV@28216|Betaproteobacteria,3733C@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Ankyrin repeat	arp3	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
TLS3_k127_8420804_1	1434325.AZQN01000002_gene984	2.324e-10	71.0	COG1876@1|root,COG1876@2|Bacteria,4NK1R@976|Bacteroidetes,47XA8@768503|Cytophagia	976|Bacteroidetes	M	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
TLS3_k127_8427797_1	1121918.ARWE01000001_gene1142	9.139e-21	100.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42URW@68525|delta/epsilon subdivisions,2WMYB@28221|Deltaproteobacteria,43SFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS3_k127_8427797_2	1121090.KB894706_gene982	1.172e-12	77.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,4HIQ4@91061|Bacilli,1ZRQQ@1386|Bacillus	91061|Bacilli	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS3_k127_8427797_0	1266908.AQPB01000027_gene647	1.22e-47	183.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1WWYX@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,Radical_SAM
TLS3_k127_8429465_4	382464.ABSI01000020_gene122	0.0001595	51.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,46TS1@74201|Verrucomicrobia,2ITZM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
TLS3_k127_8429465_2	1121439.dsat_2525	8.093e-19	90.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg
TLS3_k127_8429465_1	386456.JQKN01000001_gene2316	7.967e-60	221.0	arCOG02349@1|root,arCOG06721@1|root,arCOG02349@2157|Archaea,arCOG06721@2157|Archaea,2Y2Z1@28890|Euryarchaeota	28890|Euryarchaeota	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2
TLS3_k127_8429465_3	504472.Slin_1882	4.051e-16	81.0	COG4251@1|root,COG4251@2|Bacteria,4NTN4@976|Bacteroidetes,47RN1@768503|Cytophagia	976|Bacteroidetes	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
TLS3_k127_8429465_0	879212.DespoDRAFT_03175	5.42e-107	364.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria,2MNQI@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
TLS3_k127_8434272_0	1239962.C943_00996	3e-33	133.0	COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,47JC4@768503|Cytophagia	976|Bacteroidetes	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran,OEP
TLS3_k127_8434272_1	1280949.HAD_15462	1.437e-08	66.0	COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria,43XPN@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	COG0208 Ribonucleotide reductase, beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	AurF
TLS3_k127_8434272_2	1122194.AUHU01000002_gene2861	6.091e-08	59.0	2E5SG@1|root,330GY@2|Bacteria,1NB2M@1224|Proteobacteria,1SCUK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8436501_0	400682.PAC_15716088	4.411e-41	174.0	COG0666@1|root,KOG0502@2759|Eukaryota,KOG0504@2759|Eukaryota,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta	33154|Opisthokonta	M	protein localization to T-tubule	-	-	-	ko:K10380,ko:K15503,ko:K21440	ko04624,ko05205,map04624,map05205	-	-	-	ko00000,ko00001,ko01009,ko03400,ko04131,ko04812	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
TLS3_k127_8436501_1	5722.XP_001302501.1	1.279e-12	74.0	COG0666@1|root,KOG4177@2759|Eukaryota	5722.XP_001302501.1|-	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8440095_2	33876.JNXY01000044_gene1841	1.14e-05	47.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4D8F7@85008|Micromonosporales	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS3_k127_8440095_1	1388763.O165_006575	1.167e-10	76.0	COG2132@1|root,COG2132@2|Bacteria,1QVES@1224|Proteobacteria,1T2CX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Phage tail tube, TTP, lambda-like	-	-	-	-	-	-	-	-	-	-	-	-	Phage_TTP_11
TLS3_k127_8440095_3	1346330.M472_19575	4.951e-05	57.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.14.14.47	ko:K00491,ko:K21572	ko00220,ko00330,ko01100,ko01110,map00220,map00330,map01100,map01110	-	R11711,R11712,R11713	RC00177,RC00330,RC01044	ko00000,ko00001,ko01000,ko02000	8.A.46.1,8.A.46.3	-	-	EF-hand_5,FAD_binding_6,Fer2_BFD,NAD_binding_1,NAD_binding_10,NO_synthase,SusD-like_3,SusD_RagB
TLS3_k127_8440095_0	649747.HMPREF0083_02736	9.213e-30	123.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli,27783@186822|Paenibacillaceae	91061|Bacilli	NT	Chemotaxis protein cheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
TLS3_k127_8442793_0	153721.MYP_1818	1.238e-172	553.0	COG3158@1|root,COG3158@2|Bacteria,4NET9@976|Bacteroidetes,47K58@768503|Cytophagia	976|Bacteroidetes	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TLS3_k127_8442793_1	755732.Fluta_2304	3.844e-87	291.0	COG3158@1|root,COG3158@2|Bacteria,4NET9@976|Bacteroidetes,1HX75@117743|Flavobacteriia	976|Bacteroidetes	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
TLS3_k127_8442987_0	693661.Arcve_1955	8.5e-27	121.0	COG1482@1|root,arCOG10219@2157|Archaea,2XZYE@28890|Euryarchaeota,247BQ@183980|Archaeoglobi	183980|Archaeoglobi	G	Phosphomannose isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
TLS3_k127_8442987_1	926556.Echvi_3625	6.109e-13	78.0	COG1960@1|root,COG1960@2|Bacteria,4NEM4@976|Bacteroidetes,47U95@768503|Cytophagia	976|Bacteroidetes	C	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS3_k127_8447404_0	1397527.Q670_09495	4.218e-20	91.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XN10@135619|Oceanospirillales	135619|Oceanospirillales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
TLS3_k127_8447404_1	1046627.BZARG_2148	2.615e-07	54.0	COG0225@1|root,COG0225@2|Bacteria,4NI9D@976|Bacteroidetes,1I0XI@117743|Flavobacteriia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS3_k127_8447404_2	1298863.AUEP01000007_gene280	3.284e-06	58.0	COG2114@1|root,COG2770@1|root,COG2114@2|Bacteria,COG2770@2|Bacteria,2GJRI@201174|Actinobacteria,4DNYW@85009|Propionibacteriales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1319c	Guanylate_cyc,HAMP
TLS3_k127_8450696_0	1006004.GBAG_3158	1.324e-43	184.0	COG2373@1|root,COG3420@1|root,COG4932@1|root,COG2373@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T2KS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
TLS3_k127_8455653_0	72664.XP_006391044.1	7.785e-09	61.0	2DPQK@1|root,2S6A2@2759|Eukaryota,388KT@33090|Viridiplantae,3GXPM@35493|Streptophyta,3HYNC@3699|Brassicales	35493|Streptophyta	S	RimP N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF150
TLS3_k127_8459999_4	589865.DaAHT2_1216	3.674e-56	208.0	COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,42N9H@68525|delta/epsilon subdivisions,2WJMK@28221|Deltaproteobacteria,2MIEP@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_9
TLS3_k127_8459999_3	879212.DespoDRAFT_00919	1.365e-59	224.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,2MHMS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
TLS3_k127_8459999_7	1278073.MYSTI_04890	1.75e-29	127.0	COG5662@1|root,COG5662@2|Bacteria,1R2VH@1224|Proteobacteria	1224|Proteobacteria	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS3_k127_8459999_1	1118055.CAGU01000006_gene966	6.054e-88	299.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,22G2A@1570339|Peptoniphilaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS3_k127_8459999_2	525903.Taci_0743	2.155e-66	231.0	COG0264@1|root,COG0264@2|Bacteria,3TA46@508458|Synergistetes	508458|Synergistetes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS3_k127_8459999_0	1144275.COCOR_02225	2.821e-92	309.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2YU4R@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS3_k127_8459999_5	1121413.JMKT01000008_gene1645	1.704e-48	179.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2M8XC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS3_k127_8459999_6	349741.Amuc_1193	2.469e-34	134.0	COG0020@1|root,COG0020@2|Bacteria,46SMY@74201|Verrucomicrobia,2IU5V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS3_k127_8471277_1	63737.Npun_F3677	4.623e-30	130.0	COG0784@1|root,COG3920@1|root,COG0784@2|Bacteria,COG3920@2|Bacteria,1GPYK@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA_2,PAS,PAS_3,PAS_9,Response_reg
TLS3_k127_8471277_0	1128421.JAGA01000002_gene1765	2.265e-45	173.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
TLS3_k127_8471277_2	1121441.AUCX01000016_gene2358	3.732e-10	64.0	COG0745@1|root,COG2206@1|root,COG0745@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42YJ6@68525|delta/epsilon subdivisions,2WURA@28221|Deltaproteobacteria,2MH8V@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	HD,PAS_4,PAS_9,Response_reg
TLS3_k127_8472346_4	6412.HelroP170433	4.345e-05	54.0	28KPY@1|root,2QT5X@2759|Eukaryota,3A9XV@33154|Opisthokonta	33154|Opisthokonta	M	Nucleotide-diphospho-sugar transferase	-	-	-	ko:K20784	ko00514,map00514	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT77	-	Nucleotid_trans
TLS3_k127_8472346_5	522306.CAP2UW1_3566	0.0001275	51.0	2E3ZS@1|root,32YWP@2|Bacteria,1NAZV@1224|Proteobacteria,2W4P7@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8472346_3	247634.GPB2148_2708	8.9e-07	51.0	2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria,1SHN2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8472346_0	1000565.METUNv1_01977	4.883e-254	796.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2VHAK@28216|Betaproteobacteria,2KUSP@206389|Rhodocyclales	206389|Rhodocyclales	H	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
TLS3_k127_8472346_6	118161.KB235922_gene1040	0.0001817	53.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8472346_2	1121930.AQXG01000007_gene434	4.699e-72	255.0	COG0438@1|root,COG0438@2|Bacteria,4NGZA@976|Bacteroidetes	976|Bacteroidetes	M	Stealth protein CR2, conserved region 2	-	-	-	-	-	-	-	-	-	-	-	-	Stealth_CR1,Stealth_CR2,Stealth_CR3,Stealth_CR4
TLS3_k127_8472346_1	1298920.KI911353_gene3123	1.331e-105	364.0	COG0079@1|root,COG1213@1|root,COG0079@2|Bacteria,COG1213@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,21ZU1@1506553|Lachnoclostridium	186801|Clostridia	EM	Nucleotidyl transferase	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,NTP_transf_3
TLS3_k127_8476526_0	59374.Fisuc_2276	2.589e-136	443.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_8476526_1	59374.Fisuc_2591	4.843e-82	289.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_8476841_1	1227453.C444_01072	4.347e-10	63.0	COG0477@1|root,arCOG00130@2157|Archaea,2XVFS@28890|Euryarchaeota,23UCU@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_8476841_0	309801.trd_0207	1.198e-22	108.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2G7WZ@200795|Chloroflexi,27XSW@189775|Thermomicrobia	189775|Thermomicrobia	L	GIY-YIG type nucleases (URI domain)	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
TLS3_k127_8479311_0	743722.Sph21_0369	5.148e-62	229.0	COG1160@1|root,COG1160@2|Bacteria,4NE2J@976|Bacteroidetes,1IR18@117747|Sphingobacteriia	976|Bacteroidetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS3_k127_8484118_1	504487.JCM19302_4138	8.881e-07	55.0	29E7I@1|root,3015I@2|Bacteria,4NNFG@976|Bacteroidetes,1I2ET@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
TLS3_k127_8484118_0	765420.OSCT_0603	2.958e-27	119.0	COG2267@1|root,COG2267@2|Bacteria,2GB91@200795|Chloroflexi,377KC@32061|Chloroflexia	32061|Chloroflexia	I	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8487482_1	56780.SYN_02636	1.633e-59	214.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MQGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein domain	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS3_k127_8487482_0	644282.Deba_2884	3.853e-72	254.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS3_k127_8497541_0	861299.J421_2443	1.195e-33	132.0	COG0177@1|root,COG0177@2|Bacteria,1ZT7K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS3_k127_8497541_1	1297617.JPJD01000020_gene329	7.962e-29	127.0	COG1075@1|root,COG1075@2|Bacteria,1TQFF@1239|Firmicutes,2494B@186801|Clostridia,26AW6@186813|unclassified Clostridiales	186801|Clostridia	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF676,PGAP1
TLS3_k127_8497541_3	760192.Halhy_3522	6.256e-18	87.0	2DZQQ@1|root,32VGE@2|Bacteria,4NTQG@976|Bacteroidetes,1IUJT@117747|Sphingobacteriia	976|Bacteroidetes	S	Transmembrane family 220, helix	-	-	-	-	-	-	-	-	-	-	-	-	TMEM220
TLS3_k127_8497541_4	1392498.JQLH01000001_gene1496	3.453e-07	60.0	COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,1HXN5@117743|Flavobacteriia,2PG7R@252356|Maribacter	976|Bacteroidetes	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS3_k127_8497541_2	517418.Ctha_2171	3.555e-22	106.0	COG1127@1|root,COG1127@2|Bacteria	2|Bacteria	Q	ATPase activity	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS3_k127_8497823_0	1380387.JADM01000002_gene1910	1.404e-48	194.0	COG3391@1|root,COG3391@2|Bacteria,1MWMT@1224|Proteobacteria,1S7U7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
TLS3_k127_8498013_1	1121373.KB903664_gene2604	1.33e-18	91.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NHCE@976|Bacteroidetes,47NZ4@768503|Cytophagia	976|Bacteroidetes	MU	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
TLS3_k127_8498633_2	1089547.KB913013_gene1188	1.086e-09	63.0	COG0607@1|root,COG0607@2|Bacteria,4NSD1@976|Bacteroidetes,47R62@768503|Cytophagia	976|Bacteroidetes	P	PFAM Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_8498633_0	1379270.AUXF01000004_gene2893	1.139e-148	488.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS3_k127_8498633_3	992406.RIA_1109	1.132e-09	60.0	COG0607@1|root,COG0607@2|Bacteria,4PFI6@976|Bacteroidetes,1I75C@117743|Flavobacteriia	976|Bacteroidetes	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8498633_4	1117647.M5M_18645	0.0007338	47.0	COG1937@1|root,COG1937@2|Bacteria,1N6ZN@1224|Proteobacteria,1S6I2@1236|Gammaproteobacteria,1J71M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	rcnR	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
TLS3_k127_8498633_1	246197.MXAN_4314	1.069e-20	99.0	COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,2Z1G5@29|Myxococcales	28221|Deltaproteobacteria	P	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
TLS3_k127_850282_1	1121920.AUAU01000019_gene2604	4.585e-17	89.0	COG4659@1|root,COG4659@2|Bacteria	2|Bacteria	C	FMN binding	rnfG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
TLS3_k127_850282_0	1121920.AUAU01000019_gene2603	8.543e-91	314.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K12065	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	Porin_O_P
TLS3_k127_8505689_0	1353529.M899_1121	8.774e-50	190.0	COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP dicarboxylate transporter- DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS3_k127_8507424_5	1123252.ATZF01000004_gene2006	7.634e-11	64.0	COG2259@1|root,31BQE@2|Bacteria,1V7K9@1239|Firmicutes,4HJ13@91061|Bacilli	91061|Bacilli	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
TLS3_k127_8507424_4	265729.GS18_0206560	2.122e-17	86.0	COG0202@1|root,COG0202@2|Bacteria,1VD02@1239|Firmicutes,4HKNS@91061|Bacilli,1ZII0@1386|Bacillus	91061|Bacilli	K	COG0202 DNA-directed RNA polymerase, alpha subunit 40 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	RNA_pol_A_CTD
TLS3_k127_8507424_3	362418.IW19_15945	8.372e-25	108.0	COG3801@1|root,COG3801@2|Bacteria,4NSK5@976|Bacteroidetes,1IAE8@117743|Flavobacteriia,2NWR1@237|Flavobacterium	976|Bacteroidetes	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS3_k127_8507424_1	1207063.P24_01425	3.623e-48	178.0	COG0454@1|root,COG0456@2|Bacteria,1RHEU@1224|Proteobacteria,2U9CP@28211|Alphaproteobacteria,2JWS4@204441|Rhodospirillales	204441|Rhodospirillales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_8507424_0	1144319.PMI16_02809	5.729e-63	219.0	COG3832@1|root,COG3832@2|Bacteria,1RI7Y@1224|Proteobacteria,2VW09@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_8507424_2	485918.Cpin_4592	4.552e-32	126.0	2E5NA@1|root,330D3@2|Bacteria,4NUZF@976|Bacteroidetes,1IU4P@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
TLS3_k127_8507424_6	479432.Sros_0431	2.082e-10	62.0	COG0596@1|root,COG0596@2|Bacteria,2I32Y@201174|Actinobacteria,4ER3J@85012|Streptosporangiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_8508050_0	1120973.AQXL01000122_gene127	2.793e-255	803.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,4HB5N@91061|Bacilli	91061|Bacilli	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS3_k127_8508050_1	1121422.AUMW01000019_gene1815	1.807e-37	153.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1UI8N@1239|Firmicutes,25EE0@186801|Clostridia,260HY@186807|Peptococcaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,GGDEF
TLS3_k127_8508246_0	42565.FP66_02335	3.577e-25	108.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales	135619|Oceanospirillales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS3_k127_8508602_1	309807.SRU_0707	1.11e-11	76.0	2BFSX@1|root,329MV@2|Bacteria,4P7GD@976|Bacteroidetes	309807.SRU_0707|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8508602_0	196367.JNFG01000030_gene8544	3.67e-13	78.0	COG1595@1|root,COG1595@2|Bacteria,1PT8E@1224|Proteobacteria,2W1XX@28216|Betaproteobacteria,1K2WI@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_8512171_1	1480694.DC28_00135	7.759e-07	60.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS3_k127_8512171_0	1229781.C272_03600	6.672e-47	179.0	COG0560@1|root,COG0560@2|Bacteria,2GJDH@201174|Actinobacteria,4F88J@85019|Brevibacteriaceae	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
TLS3_k127_8512685_0	319225.Plut_1748	5.423e-124	403.0	COG0074@1|root,COG0074@2|Bacteria,1FD8P@1090|Chlorobi	1090|Chlorobi	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS3_k127_8512685_2	411459.RUMOBE_00206	2.089e-35	141.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,3Y03J@572511|Blautia	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS3_k127_8512685_1	1254432.SCE1572_22855	2.954e-105	355.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria,2YXF6@29|Myxococcales	28221|Deltaproteobacteria	C	Pyruvate dehydrogenase	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Transket_pyr,Transketolase_C
TLS3_k127_8512685_3	497321.C664_11167	2.252e-07	56.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2VQAQ@28216|Betaproteobacteria,2KW2Q@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
TLS3_k127_8518743_1	269798.CHU_2715	4.047e-37	156.0	COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NHCE@976|Bacteroidetes,47NZ4@768503|Cytophagia	976|Bacteroidetes	MU	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
TLS3_k127_8518743_0	358220.C380_19495	4.703e-75	265.0	COG0753@1|root,COG0753@2|Bacteria,1N4WM@1224|Proteobacteria,2VV71@28216|Betaproteobacteria,4AI8G@80864|Comamonadaceae	28216|Betaproteobacteria	P	Catalase	-	-	-	-	-	-	-	-	-	-	-	-	Catalase
TLS3_k127_8518743_2	318161.Sden_1206	2.863e-09	61.0	COG3728@1|root,32VVZ@2|Bacteria,1N3FD@1224|Proteobacteria,1SCUV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	terminase	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
TLS3_k127_8522136_0	1387312.BAUS01000002_gene827	6.035e-80	271.0	COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,2VJ0E@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS3_k127_8522136_1	395961.Cyan7425_0758	3.538e-52	196.0	COG0657@1|root,COG0657@2|Bacteria,1G3P7@1117|Cyanobacteria,3KHVC@43988|Cyanothece	1117|Cyanobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	-	-	3.1.1.83	ko:K01066,ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
TLS3_k127_8528741_1	261292.Nit79A3_1546	3.424e-08	64.0	COG1075@1|root,COG1075@2|Bacteria,1P9W7@1224|Proteobacteria,2WBXR@28216|Betaproteobacteria,373ZK@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PGAP1-like protein	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	PGAP1
TLS3_k127_8528741_0	70601.3257678	2.478e-09	64.0	COG2265@1|root,arCOG00122@2157|Archaea,2XW70@28890|Euryarchaeota,2439C@183968|Thermococci	183968|Thermococci	J	Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA	-	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.189	ko:K03212	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
TLS3_k127_8532344_0	1094466.KQS_06670	2.186e-95	319.0	COG1808@1|root,COG1808@2|Bacteria,4NDXI@976|Bacteroidetes,1HXBV@117743|Flavobacteriia,2NU3P@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
TLS3_k127_8540327_0	596152.DesU5LDRAFT_2267	6.87e-26	123.0	COG1129@1|root,COG1129@2|Bacteria,1QUMV@1224|Proteobacteria,42Q9M@68525|delta/epsilon subdivisions,2X8BR@28221|Deltaproteobacteria,2MGDV@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	ATPases associated with a variety of cellular activities	-	-	-	ko:K05776	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	ABC_tran
TLS3_k127_854712_1	1038858.AXBA01000006_gene814	2.216e-06	54.0	2DIBA@1|root,302MG@2|Bacteria,1NGIQ@1224|Proteobacteria,2V04D@28211|Alphaproteobacteria,3F05H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Cysteine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
TLS3_k127_854712_2	251221.35212330	0.0002771	51.0	COG1595@1|root,COG1595@2|Bacteria,1G34M@1117|Cyanobacteria	1117|Cyanobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_854712_0	1120965.AUBV01000009_gene3114	7.357e-26	109.0	COG2852@1|root,COG2852@2|Bacteria,4NUSE@976|Bacteroidetes,47R33@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS3_k127_854736_0	1089553.Tph_c12900	8.606e-92	316.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,42F4D@68295|Thermoanaerobacterales	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS3_k127_854736_1	926566.Terro_1378	5.31e-11	63.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria,2JIC5@204432|Acidobacteriia	204432|Acidobacteriia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
TLS3_k127_8554181_0	1123058.KB894219_gene202	6.017e-32	133.0	COG0596@1|root,COG0596@2|Bacteria,4PKKR@976|Bacteroidetes,1IJBZ@117743|Flavobacteriia	976|Bacteroidetes	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,UPF0227
TLS3_k127_8557357_0	582744.Msip34_2446	1.295e-17	96.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,2KMI5@206350|Nitrosomonadales	206350|Nitrosomonadales	I	phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsB	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
TLS3_k127_8562668_0	204669.Acid345_4578	4.109e-18	94.0	COG1309@1|root,COG1309@2|Bacteria,3Y8NY@57723|Acidobacteria,2JNEU@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS3_k127_8564669_0	161156.JQKW01000013_gene138	1.316e-114	383.0	COG0111@1|root,COG0111@2|Bacteria,2GH7H@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS3_k127_8564669_2	68170.KL590477_gene2379	5.851e-21	104.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MetW,Methyltransf_11,Methyltransf_23
TLS3_k127_8564669_1	880526.KE386488_gene1823	1.203e-37	153.0	COG1216@1|root,COG1216@2|Bacteria,4PKFB@976|Bacteroidetes,2FSAV@200643|Bacteroidia,22VCA@171550|Rikenellaceae	976|Bacteroidetes	S	N-terminal domain of galactosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
TLS3_k127_856513_0	1313421.JHBV01000030_gene2082	4.823e-72	249.0	COG3000@1|root,COG3000@2|Bacteria,4NFWX@976|Bacteroidetes	976|Bacteroidetes	I	sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_8582063_0	1210884.HG799469_gene13956	5.742e-36	145.0	COG1136@1|root,COG1136@2|Bacteria,2IY81@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_8582063_1	595494.Tola_1572	1.45e-28	127.0	COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,1Y3DP@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	pdxB	-	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C,DUF3410
TLS3_k127_8584293_5	426355.Mrad2831_6183	1.674e-33	136.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JQYU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,Response_reg
TLS3_k127_8584293_2	44251.PDUR_13465	1.563e-80	276.0	COG4430@1|root,COG4430@2|Bacteria,1UYP9@1239|Firmicutes,4HDZD@91061|Bacilli,26RX5@186822|Paenibacillaceae	91061|Bacilli	S	Bacteriocin-protection, YdeI or OmpD-Associated	ydeI	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
TLS3_k127_8584293_0	1123023.JIAI01000004_gene8202	1.01e-163	528.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4E1FK@85010|Pseudonocardiales	201174|Actinobacteria	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS3_k127_8584293_1	118173.KB235914_gene803	1.367e-91	328.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GAF,GGDEF,PHY
TLS3_k127_8584293_3	1004785.AMBLS11_07155	7.052e-50	184.0	COG3195@1|root,COG3195@2|Bacteria,1RIGR@1224|Proteobacteria,1S6QX@1236|Gammaproteobacteria,467QT@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	OHCU decarboxylase	uraD	-	4.1.1.97	ko:K16840	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06604	RC01551	ko00000,ko00001,ko00002,ko01000	-	-	-	OHCU_decarbox
TLS3_k127_8584293_4	1384054.N790_01290	4.279e-43	161.0	COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria,1S6M1@1236|Gammaproteobacteria,1XAJC@135614|Xanthomonadales	135614|Xanthomonadales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
TLS3_k127_8585964_2	1410632.JHWW01000004_gene1697	2.551e-18	85.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,27II0@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
TLS3_k127_8585964_0	232348.ADXL01000074_gene13	3.841e-86	302.0	COG0141@1|root,COG0141@2|Bacteria,1G1I2@1117|Cyanobacteria,1GYAR@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS3_k127_8585964_1	215803.DB30_7241	8.919e-41	159.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,4372N@68525|delta/epsilon subdivisions,2X1UJ@28221|Deltaproteobacteria,2Z0EY@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_8587082_1	502025.Hoch_3708	3.332e-97	326.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2YUGD@29|Myxococcales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS3_k127_8587082_0	1280944.HY17_14180	3.508e-103	344.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,43X0Q@69657|Hyphomonadaceae	28211|Alphaproteobacteria	GM	NAD-dependent	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS3_k127_8588188_3	1242864.D187_009279	1.714e-22	97.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales	28221|Deltaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS3_k127_8588188_0	1333507.AUTQ01000242_gene1792	9.367e-147	486.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg,dCache_1
TLS3_k127_8588188_2	1333507.AUTQ01000242_gene1793	8.611e-24	105.0	COG0745@1|root,COG0745@2|Bacteria	1333507.AUTQ01000242_gene1793|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8588188_1	1333507.AUTQ01000242_gene1794	1.065e-138	449.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2Q1AE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	rpfG	-	-	ko:K07814,ko:K13815	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HD,HD_5,Response_reg
TLS3_k127_8589047_0	1120966.AUBU01000012_gene17	4.545e-35	142.0	2E29H@1|root,32X6D@2|Bacteria,4NSA2@976|Bacteroidetes,47RCG@768503|Cytophagia	976|Bacteroidetes	S	Acetoacetate decarboxylase (ADC)	-	-	-	-	-	-	-	-	-	-	-	-	ADC
TLS3_k127_8589047_1	390874.Tpet_1323	2.873e-20	95.0	COG1940@1|root,COG1940@2|Bacteria,2GCCT@200918|Thermotogae	200918|Thermotogae	G	PFAM ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS3_k127_864524_1	1415779.JOMH01000001_gene674	6.781e-31	132.0	COG3550@1|root,COG3550@2|Bacteria,1QJ5P@1224|Proteobacteria,1RP64@1236|Gammaproteobacteria,1X369@135614|Xanthomonadales	135614|Xanthomonadales	S	HipA-like C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HipA_C
TLS3_k127_864524_0	1121405.dsmv_1861	9.066e-127	422.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,PTS_EIIA_2
TLS3_k127_867886_0	1353529.M899_1534	1.014e-47	190.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2MSVZ@213481|Bdellovibrionales,2WJ7A@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	SMART PDZ DHR GLGF domain protein	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
TLS3_k127_867886_1	760011.Spico_0380	0.0001582	52.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_884806_1	324925.Ppha_2093	3.525e-65	235.0	COG1209@1|root,COG1209@2|Bacteria,1FD8Z@1090|Chlorobi	1090|Chlorobi	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
TLS3_k127_884806_0	545693.BMQ_4543	1.397e-75	276.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,4HAG2@91061|Bacilli,1ZC16@1386|Bacillus	91061|Bacilli	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TLS3_k127_884806_8	926549.KI421517_gene2133	4.209e-07	55.0	COG0828@1|root,COG0828@2|Bacteria,4NUPV@976|Bacteroidetes,47RU4@768503|Cytophagia	976|Bacteroidetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TLS3_k127_884806_4	1192034.CAP_1502	7.326e-53	205.0	2AGSA@1|root,31707@2|Bacteria,1PY8B@1224|Proteobacteria,4355T@68525|delta/epsilon subdivisions,2WZGR@28221|Deltaproteobacteria,2Z247@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_884806_3	1192034.CAP_1501	3.341e-53	205.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N1I@68525|delta/epsilon subdivisions,2WNI2@28221|Deltaproteobacteria,2YV54@29|Myxococcales	28221|Deltaproteobacteria	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
TLS3_k127_884806_6	221288.JH992901_gene3651	6.366e-26	110.0	COG4634@1|root,COG4634@2|Bacteria,1GKHI@1117|Cyanobacteria,1JM7P@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
TLS3_k127_884806_5	195253.Syn6312_3343	1.871e-29	118.0	COG2442@1|root,COG2442@2|Bacteria,1G8BN@1117|Cyanobacteria,1H21P@1129|Synechococcus	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS3_k127_884806_7	1173022.Cri9333_2145	1.182e-15	82.0	COG1943@1|root,COG1943@2|Bacteria,1G5SV@1117|Cyanobacteria,1HBAQ@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
TLS3_k127_884806_2	742725.HMPREF9450_01111	1.126e-61	225.0	COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,2FM28@200643|Bacteroidia,22UYZ@171550|Rikenellaceae	976|Bacteroidetes	I	Acyl-CoA dehydrogenase, C-terminal domain	acd	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_dehyd_C
TLS3_k127_909667_1	269799.Gmet_2342	3.405e-14	80.0	COG1216@1|root,COG1216@2|Bacteria,1R4ZP@1224|Proteobacteria,432JF@68525|delta/epsilon subdivisions,2WY2J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_909667_0	1313421.JHBV01000031_gene1507	1.123e-17	91.0	2DP10@1|root,3302V@2|Bacteria,4PMCJ@976|Bacteroidetes	976|Bacteroidetes	S	START domain	-	-	-	-	-	-	-	-	-	-	-	-	START
TLS3_k127_913619_0	765952.PUV_13560	1.82e-101	344.0	COG0161@1|root,COG0161@2|Bacteria,2JGX8@204428|Chlamydiae	204428|Chlamydiae	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_913619_1	329726.AM1_1733	1.756e-85	297.0	COG0502@1|root,COG0502@2|Bacteria,1G3B8@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.bioB	BATS,Radical_SAM
TLS3_k127_913735_1	349521.HCH_01096	8.571e-69	239.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria,1XIV8@135619|Oceanospirillales	135619|Oceanospirillales	F	dihydroorotase	-	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS3_k127_913735_0	1502852.FG94_02520	7.347e-133	434.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,473XM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
TLS3_k127_913735_2	158189.SpiBuddy_2449	3.081e-12	77.0	COG1357@1|root,COG4733@1|root,COG4886@1|root,COG5279@1|root,COG1357@2|Bacteria,COG4733@2|Bacteria,COG4886@2|Bacteria,COG5279@2|Bacteria	2|Bacteria	D	protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_3,Flg_new,LRR_5,Mfa_like_1,RCC1
TLS3_k127_913735_3	713587.THITH_09770	8.826e-05	53.0	COG0515@1|root,COG1404@1|root,COG0515@2|Bacteria,COG1404@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,1WXY7@135613|Chromatiales	135613|Chromatiales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS3_k127_918731_1	1184267.A11Q_1050	3.721e-15	81.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2MTW3@213481|Bdellovibrionales,2WKTX@28221|Deltaproteobacteria	213481|Bdellovibrionales	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
TLS3_k127_918731_0	452637.Oter_2161	1.886e-46	175.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
TLS3_k127_929786_0	1122194.AUHU01000005_gene985	0.000108	54.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1R5Q7@1224|Proteobacteria,1RPH2@1236|Gammaproteobacteria,465FR@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
TLS3_k127_935968_0	404589.Anae109_3852	4.579e-120	394.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TLS3_k127_935968_1	123214.PERMA_0218	2.659e-36	150.0	COG1104@1|root,COG1104@2|Bacteria,2G4RH@200783|Aquificae	200783|Aquificae	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS3_k127_936871_0	179408.Osc7112_1554	2.081e-65	236.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
TLS3_k127_939402_2	620914.JH621287_gene1416	5.639e-16	85.0	COG3014@1|root,COG3014@2|Bacteria,4NIIU@976|Bacteroidetes,1I0JV@117743|Flavobacteriia,2YITE@290174|Aquimarina	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	TPR_2
TLS3_k127_939402_0	1519464.HY22_10520	1.909e-68	240.0	COG0586@1|root,COG0586@2|Bacteria,1FE4G@1090|Chlorobi	1090|Chlorobi	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
TLS3_k127_939402_1	1415779.JOMH01000001_gene2295	7.295e-26	114.0	COG1309@1|root,COG1309@2|Bacteria,1MUJ5@1224|Proteobacteria,1RN9W@1236|Gammaproteobacteria,1X3N6@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional regulator	fabR	-	-	ko:K22105	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS3_k127_940546_1	998674.ATTE01000001_gene3321	0.0002247	54.0	COG1234@1|root,COG1234@2|Bacteria,1QE3B@1224|Proteobacteria,1RZJQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	of the beta-lactamase superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_940546_0	7955.ENSDARP00000085704	6.29e-10	72.0	COG0664@1|root,KOG0614@2759|Eukaryota,3AH8Y@33154|Opisthokonta,3BA35@33208|Metazoa,3CRYY@33213|Bilateria,47ZK6@7711|Chordata,491XR@7742|Vertebrata,4A07P@7898|Actinopterygii	33208|Metazoa	T	cGMP-dependent protein kinase	-	-	2.7.11.12	ko:K19477	ko04022,ko04540,ko04611,ko04713,ko04714,ko04730,ko04740,ko04923,ko04924,ko04970,map04022,map04540,map04611,map04713,map04714,map04730,map04740,map04923,map04924,map04970	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
TLS3_k127_946215_1	468059.AUHA01000006_gene2907	6.781e-29	120.0	COG0730@1|root,COG0730@2|Bacteria,4NTZ8@976|Bacteroidetes	976|Bacteroidetes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_946215_0	96561.Dole_2193	8.843e-41	157.0	COG0451@1|root,COG0451@2|Bacteria,1PE5Z@1224|Proteobacteria,43A0H@68525|delta/epsilon subdivisions,2X262@28221|Deltaproteobacteria,2MN1V@213118|Desulfobacterales	28221|Deltaproteobacteria	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_947999_2	1122604.JONR01000020_gene510	2.993e-34	140.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,1S0UK@1236|Gammaproteobacteria,1X4IW@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
TLS3_k127_947999_3	272624.lpg2483	3.079e-16	86.0	COG2128@1|root,COG2128@2|Bacteria,1RC52@1224|Proteobacteria,1S2A0@1236|Gammaproteobacteria,1JGNC@118969|Legionellales	118969|Legionellales	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS3_k127_947999_1	1173024.KI912149_gene5983	2.326e-58	214.0	COG1595@1|root,COG1595@2|Bacteria,1G0NE@1117|Cyanobacteria,1JK91@1189|Stigonemataceae	1117|Cyanobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_947999_0	698758.AXY_10960	4.092e-109	361.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,4HASA@91061|Bacilli	91061|Bacilli	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS3_k127_954282_0	83406.HDN1F_15990	6.434e-308	958.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1J4JG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit	-	-	5.4.99.2,5.4.99.63	ko:K01847,ko:K14447	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833,R09292	RC00395,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS3_k127_954282_1	981223.AIED01000078_gene680	1.382e-44	172.0	COG0412@1|root,COG0412@2|Bacteria,1PSEB@1224|Proteobacteria,1RNZS@1236|Gammaproteobacteria,3NKZ0@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
TLS3_k127_954282_2	582402.Hbal_2344	1.596e-40	162.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,43WDX@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS3_k127_955873_0	765869.BDW_13700	2.103e-50	188.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2MSQ6@213481|Bdellovibrionales,2WIXF@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
TLS3_k127_955873_1	765912.Thimo_0509	0.0004295	47.0	COG2198@1|root,COG2198@2|Bacteria,1QN0K@1224|Proteobacteria,1TKC8@1236|Gammaproteobacteria,1X1SV@135613|Chromatiales	135613|Chromatiales	T	Histidine Phosphotransfer domain	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt
TLS3_k127_956728_0	402626.Rpic_0025	3.422e-07	58.0	COG2706@1|root,COG3391@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,1RB38@1224|Proteobacteria,2VSAM@28216|Betaproteobacteria,1K6NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_956767_3	1200792.AKYF01000006_gene1344	1.763e-07	64.0	COG3469@1|root,COG3469@2|Bacteria,1TQIF@1239|Firmicutes,4HDT6@91061|Bacilli,26THM@186822|Paenibacillaceae	91061|Bacilli	G	chitinase	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,Glyco_hydro_18,fn3
TLS3_k127_956767_2	1123020.AUIE01000001_gene2404	1.523e-31	143.0	COG2373@1|root,COG2931@1|root,COG2982@1|root,COG3210@1|root,COG4932@1|root,COG5184@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria,1YFJH@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	MQU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
TLS3_k127_956767_0	1123276.KB893254_gene3450	1.773e-66	252.0	COG1502@1|root,COG2374@1|root,COG1502@2|Bacteria,COG2374@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	DUF3494,He_PIG,PLDc_2,VCBS
TLS3_k127_956767_1	1201288.M900_1998	5.899e-46	173.0	COG3651@1|root,COG3651@2|Bacteria,1RH68@1224|Proteobacteria,42TUY@68525|delta/epsilon subdivisions,2WQCV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
TLS3_k127_956767_4	504487.JCM19302_3193	1.748e-05	50.0	COG3103@1|root,COG3103@2|Bacteria,4NU2A@976|Bacteroidetes,1I4GG@117743|Flavobacteriia	976|Bacteroidetes	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS3_k127_961710_1	7668.SPU_012058-tr	6.251e-17	89.0	COG0666@1|root,KOG0504@2759|Eukaryota,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria	33208|Metazoa	M	ankyrin 3, node of Ranvier (ankyrin G)	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,ZU5
TLS3_k127_961710_0	1120970.AUBZ01000041_gene564	1.241e-73	255.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,464FD@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
TLS3_k127_963790_3	1408164.MOLA814_02302	8.457e-14	73.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2VVW8@28216|Betaproteobacteria,1KQ4N@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS3_k127_963790_0	984262.SGRA_1390	2.834e-121	406.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,1IWSD@117747|Sphingobacteriia	976|Bacteroidetes	M	COG2885 Outer membrane protein and related peptidoglycan-associated	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
TLS3_k127_963790_1	765869.BDW_01675	1.101e-27	123.0	COG0811@1|root,COG0811@2|Bacteria,1NBED@1224|Proteobacteria,42WAH@68525|delta/epsilon subdivisions,2MTKG@213481|Bdellovibrionales,2X5KM@28221|Deltaproteobacteria	213481|Bdellovibrionales	U	MotA TolQ ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
TLS3_k127_963790_2	365044.Pnap_3787	3.466e-18	89.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSMV@28216|Betaproteobacteria,4AEE0@80864|Comamonadaceae	28216|Betaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS3_k127_967381_0	543728.Vapar_2712	1.389e-28	121.0	COG4271@1|root,COG4271@2|Bacteria,1PPCX@1224|Proteobacteria,2VQMZ@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Predicted nucleotide-binding protein containing TIR-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR-like
TLS3_k127_967381_1	1121923.GPUN_2838	2.798e-26	113.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,4674U@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Belongs to the MtfA family	mtfA	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
TLS3_k127_969822_1	545694.TREPR_3682	1.458e-12	71.0	COG1487@1|root,COG1487@2|Bacteria,2JABZ@203691|Spirochaetes	203691|Spirochaetes	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_969822_0	1122919.KB905573_gene3534	3.604e-71	258.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26RMX@186822|Paenibacillaceae	91061|Bacilli	G	Glycoside hydrolase family 3	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4309,Glyco_hydro_3
TLS3_k127_971323_2	526222.Desal_0896	1.433e-35	136.0	COG1803@1|root,COG1803@2|Bacteria,1RD3D@1224|Proteobacteria,42SPC@68525|delta/epsilon subdivisions,2WP55@28221|Deltaproteobacteria,2MD0A@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM Methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
TLS3_k127_971323_0	404380.Gbem_3645	2.263e-151	496.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS3_k127_971323_1	391625.PPSIR1_23629	4.2e-37	150.0	COG3687@1|root,COG3687@2|Bacteria,1R4HJ@1224|Proteobacteria	1224|Proteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
TLS3_k127_974494_1	492774.JQMB01000008_gene14	5.9e-24	104.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TR1K@28211|Alphaproteobacteria,4B85K@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
TLS3_k127_974494_0	1123277.KB893217_gene4690	4.948e-77	264.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,47JHZ@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
TLS3_k127_976072_0	1140.Synpcc7942_2139	1.593e-64	226.0	COG0625@1|root,COG0625@2|Bacteria,1G34I@1117|Cyanobacteria,1H15C@1129|Synechococcus	1117|Cyanobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS3_k127_978796_0	264462.Bd1868	8.538e-64	233.0	COG0438@1|root,COG0438@2|Bacteria,1Q4DP@1224|Proteobacteria,4346D@68525|delta/epsilon subdivisions,2MUG0@213481|Bdellovibrionales,2X1YY@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS3_k127_982711_0	264462.Bd0368	1.307e-97	330.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2MUP9@213481|Bdellovibrionales,2WMIS@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS3_k127_982711_1	1504672.669783299	2.192e-59	213.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9PT@80864|Comamonadaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS3_k127_983921_0	1123277.KB893194_gene5847	1.097e-214	672.0	COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,4NGSB@976|Bacteroidetes,47U8D@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.1.1,1.3.98.1	ko:K00226,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
TLS3_k127_983921_1	714943.Mucpa_6397	3.23e-33	131.0	COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,1IW2Z@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.3.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K17722	ko00240,ko00250,ko00410,ko00770,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00410,map00770,map00910,map01100,map01110,map01120,map01130,map01230	M00046	R00093,R00114,R00248,R00977,R01414,R11026	RC00006,RC00010,RC00072,RC00123,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
TLS3_k127_985257_2	246197.MXAN_1386	1.344e-10	63.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2YU49@29|Myxococcales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
TLS3_k127_985257_0	761193.Runsl_2437	2.608e-183	584.0	COG1251@1|root,COG1251@2|Bacteria,4NE44@976|Bacteroidetes,47M7X@768503|Cytophagia	976|Bacteroidetes	C	Nitrite and sulphite reductase 4Fe-4S	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
TLS3_k127_985257_1	388413.ALPR1_01655	1.024e-31	134.0	COG2146@1|root,COG2146@2|Bacteria,4NQQ8@976|Bacteroidetes,47QJ5@768503|Cytophagia	976|Bacteroidetes	P	TIGRFAM nitrite reductase NAD(P)H , small subunit	-	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske_2
TLS3_k127_985751_1	1123020.AUIE01000024_gene5100	4.886e-31	129.0	COG2867@1|root,COG2867@2|Bacteria,1N681@1224|Proteobacteria,1SAUK@1236|Gammaproteobacteria,1YFM6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	START domain	-	-	-	-	-	-	-	-	-	-	-	-	START
TLS3_k127_985751_0	1304888.ATWF01000001_gene2255	1.266e-45	170.0	COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,2GF8G@200930|Deferribacteres	200930|Deferribacteres	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
TLS3_k127_99193_0	717606.PaecuDRAFT_4315	7.703e-08	64.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,26T15@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like
TLS3_k127_99624_3	889378.Spiaf_2004	2.838e-37	141.0	COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
TLS3_k127_99624_0	452637.Oter_2476	3.267e-185	593.0	COG0004@1|root,COG0004@2|Bacteria,46SCE@74201|Verrucomicrobia,3K7NK@414999|Opitutae	414999|Opitutae	P	ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS3_k127_99624_2	889378.Spiaf_2004	2.811e-47	171.0	COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
TLS3_k127_99624_1	864702.OsccyDRAFT_4465	5.183e-103	342.0	COG0004@1|root,COG0004@2|Bacteria,1G0S8@1117|Cyanobacteria,1H6WR@1150|Oscillatoriales	1117|Cyanobacteria	U	ammonium transporteR	amt1	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
## 3312 queries scanned
## Total time (seconds): 221.7235724925995
## Rate: 14.94 q/s