## Thu Feb 19 19:20:47 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/TLS3_bin.2.fa -m mmseqs --output TLS3_bin.2 --output_dir /data/result/bins/wyx/eggqs50+/TLS3_bin.2 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS3_k127_1004705_1	644107.SL1157_2334	1.258e-17	86.0	2CA50@1|root,32YIT@2|Bacteria,1N822@1224|Proteobacteria,2UFR0@28211|Alphaproteobacteria,4NCNN@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2842
TLS3_k127_1004705_0	371731.Rsw2DRAFT_1445	1.373e-239	745.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,1FAUW@1060|Rhodobacter	28211|Alphaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS3_k127_1004705_2	1232429.CBLL010000103_gene1639	0.0001472	51.0	COG2124@1|root,COG2124@2|Bacteria,2I9EA@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_1042435_1	246200.SPO1675	4.212e-96	335.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria,4NAB9@97050|Ruegeria	28211|Alphaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS3_k127_1042435_0	367336.OM2255_03730	2.821e-98	327.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
TLS3_k127_1042435_3	367336.OM2255_03725	1.099e-58	211.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS3_k127_1042435_4	1402135.SUH3_05115	1.269e-18	94.0	COG2825@1|root,COG2825@2|Bacteria,1MZ4B@1224|Proteobacteria,2UC2P@28211|Alphaproteobacteria,3ZXSE@60136|Sulfitobacter	28211|Alphaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	-	-	-	-	-	-	-	-	-	OmpH
TLS3_k127_1042435_2	1530186.JQEY01000021_gene466	3.331e-80	278.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS3_k127_1047835_2	1173028.ANKO01000127_gene4148	1.947e-30	132.0	COG3240@1|root,COG3240@2|Bacteria,1FZV1@1117|Cyanobacteria,1HB7T@1150|Oscillatoriales	1117|Cyanobacteria	I	Phospholipase lecithinase hemolysin	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
TLS3_k127_1047835_0	414684.RC1_1058	2.866e-86	303.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,2JRCJ@204441|Rhodospirillales	204441|Rhodospirillales	V	MatE	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_1047835_1	1120792.JAFV01000001_gene2562	4.785e-34	136.0	COG0251@1|root,COG0251@2|Bacteria,1RH61@1224|Proteobacteria,2UAE3@28211|Alphaproteobacteria,370IH@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	rutC	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS3_k127_1053414_5	34007.IT40_03645	1.245e-55	199.0	COG0329@1|root,COG0329@2|Bacteria,1MV7E@1224|Proteobacteria,2TTT5@28211|Alphaproteobacteria,2PUI6@265|Paracoccus	28211|Alphaproteobacteria	EM	Protein of unknown function (DUF993)	MA20_16880	-	-	-	-	-	-	-	-	-	-	-	DUF993
TLS3_k127_1053414_4	1224746.B932_0660	1.166e-94	327.0	COG1028@1|root,COG1028@2|Bacteria,1RG0J@1224|Proteobacteria,2U4JH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS3_k127_1053414_3	34007.IT40_03620	3.743e-98	349.0	COG1024@1|root,COG1024@2|Bacteria,1RAIU@1224|Proteobacteria,2U5K1@28211|Alphaproteobacteria,2PVY0@265|Paracoccus	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_1053414_0	412597.AEPN01000054_gene3698	1.423e-270	840.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2TRRK@28211|Alphaproteobacteria,2PWPS@265|Paracoccus	28211|Alphaproteobacteria	I	Malonate decarboxylase, alpha subunit, transporter	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS3_k127_1053414_2	391595.RLO149_c040950	3.792e-117	384.0	COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,2TT2Q@28211|Alphaproteobacteria,2P31I@2433|Roseobacter	28211|Alphaproteobacteria	C	Aldo/keto reductase family	dkgB	-	1.1.1.346	ko:K06222	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
TLS3_k127_1053414_6	1101192.KB910516_gene2520	0.0001277	49.0	COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,2TUNU@28211|Alphaproteobacteria,1JRZK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM regulatory protein LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_1053414_1	34007.IT40_03605	1.818e-254	796.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2PWT4@265|Paracoccus	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_1062557_0	1305735.JAFT01000005_gene2108	0.0	1222.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2U1PA@28211|Alphaproteobacteria,2PFA9@252301|Oceanicola	28211|Alphaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	psrA	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS3_k127_1062557_4	388399.SSE37_18065	4.574e-121	399.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	ttrB	-	-	ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4
TLS3_k127_1062557_5	371731.Rsw2DRAFT_2643	1.106e-71	251.0	COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,2TS1K@28211|Alphaproteobacteria,1FB0K@1060|Rhodobacter	28211|Alphaproteobacteria	I	Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP	pcs	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS3_k127_1062557_2	1469613.JT55_07195	6.288e-151	486.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,3FDRF@34008|Rhodovulum	28211|Alphaproteobacteria	E	Homocysteine S-methyltransferase	yitJ	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS3_k127_1062557_6	272943.RSP_1973	1.121e-58	212.0	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,2U9A2@28211|Alphaproteobacteria,1FBU8@1060|Rhodobacter	28211|Alphaproteobacteria	S	PFAM Fe-S metabolism associated	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
TLS3_k127_1062557_7	272943.RSP_1972	4.435e-11	72.0	2E41R@1|root,32YYC@2|Bacteria,1N7DH@1224|Proteobacteria,2UFHG@28211|Alphaproteobacteria,1FC5S@1060|Rhodobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1062557_3	266809.PM03_10970	4.875e-148	479.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
TLS3_k127_1062557_1	991905.SL003B_3826	0.0	1007.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,4BPQH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
TLS3_k127_1066165_6	1423144.Gal_01567	1.242e-45	172.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,34F4V@302485|Phaeobacter	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_1066165_0	935261.JAGL01000008_gene2317	5.388e-205	647.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,43IG5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transket_pyr,Transketolase_C
TLS3_k127_1066165_1	388401.RB2150_04213	3.812e-184	579.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,3ZFZM@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS3_k127_1066165_7	398580.Dshi_2157	7.596e-18	94.0	COG2919@1|root,COG2919@2|Bacteria,1MZH9@1224|Proteobacteria,2UC4I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	septum formation initiator	-	-	-	-	-	-	-	-	-	-	-	-	DivIC
TLS3_k127_1066165_5	371731.Rsw2DRAFT_2125	1.81e-56	201.0	COG0494@1|root,COG0494@2|Bacteria,1RI5B@1224|Proteobacteria,2U9IF@28211|Alphaproteobacteria,1FBV9@1060|Rhodobacter	28211|Alphaproteobacteria	L	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS3_k127_1066165_2	1530186.JQEY01000001_gene1195	8.341e-135	438.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2TTUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
TLS3_k127_1066165_3	1231392.OCGS_0679	7.206e-99	331.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_1066165_4	384765.SIAM614_07418	5.244e-59	225.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	AI-2E family transporter	MA20_41055	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_1066165_8	290400.Jann_2426	3.316e-11	67.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS3_k127_1070251_3	1144312.PMI09_04686	4.605e-69	242.0	COG0489@1|root,COG0489@2|Bacteria,1MWQC@1224|Proteobacteria,2TXN9@28211|Alphaproteobacteria,4BAYT@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	COG0489 ATPases involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,ParA
TLS3_k127_1070251_4	1082931.KKY_2140	2.846e-65	231.0	COG1802@1|root,COG1802@2|Bacteria,1RBIC@1224|Proteobacteria,2U60T@28211|Alphaproteobacteria,3N8Q2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	FCD	MA20_22675	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_1070251_5	426117.M446_3691	1.027e-38	163.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TR00@28211|Alphaproteobacteria,1JSM8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	PFAM Amidase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS3_k127_1070251_0	1082931.KKY_2142	1.541e-166	544.0	COG0715@1|root,COG0715@2|Bacteria,1R60E@1224|Proteobacteria,2U09M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter (Periplasmic binding protein)	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS3_k127_1070251_2	1082931.KKY_2143	8.517e-118	400.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2TSAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS3_k127_1070251_1	1082931.KKY_2144	4.577e-124	402.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3N6UD@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS3_k127_107245_4	1188256.BASI01000001_gene675	3.942e-24	102.0	2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,2U9CM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4399
TLS3_k127_107245_5	587753.EY04_20915	1.436e-09	68.0	2ESJ5@1|root,33K3V@2|Bacteria	2|Bacteria	S	Membrane-bound lysozyme-inhibitor of c-type lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	MliC
TLS3_k127_107245_1	246200.SPO3541	2.145e-117	391.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,4NB3W@97050|Ruegeria	28211|Alphaproteobacteria	L	Belongs to the Nudix hydrolase family	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
TLS3_k127_107245_3	1112216.JH594425_gene114	6.009e-41	160.0	COG1045@1|root,COG1045@2|Bacteria,1RA58@1224|Proteobacteria,2VEY1@28211|Alphaproteobacteria,2KDAT@204457|Sphingomonadales	204457|Sphingomonadales	E	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
TLS3_k127_107245_2	246200.SPO1243	2.871e-47	172.0	293EG@1|root,2ZQWX@2|Bacteria,1RDP4@1224|Proteobacteria,2U79J@28211|Alphaproteobacteria,4NC4V@97050|Ruegeria	28211|Alphaproteobacteria	S	Elongation factor P	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_107245_0	1469613.JT55_13585	4.702e-304	947.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,3FCRJ@34008|Rhodovulum	28211|Alphaproteobacteria	L	PHP domain	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS3_k127_1088950_1	426117.M446_2182	6.194e-106	370.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,1JRV2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
TLS3_k127_1088950_0	1415756.JQMY01000001_gene587	1.207e-116	387.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,2PC9H@252301|Oceanicola	28211|Alphaproteobacteria	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_1088950_2	1415756.JQMY01000001_gene588	1.682e-34	136.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,2PEC3@252301|Oceanicola	28211|Alphaproteobacteria	S	OstA-like protein	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
TLS3_k127_1103256_0	314264.ROS217_22132	1.982e-222	735.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,46Q1X@74030|Roseovarius	28211|Alphaproteobacteria	H	COG3572 Gamma-glutamylcysteine synthetase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
TLS3_k127_1103256_1	1379270.AUXF01000001_gene2105	8.692e-91	320.0	COG2303@1|root,COG2303@2|Bacteria,1ZUUJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C
TLS3_k127_1103256_2	349102.Rsph17025_0215	5.524e-18	91.0	2CKED@1|root,32SC7@2|Bacteria,1MZAN@1224|Proteobacteria,2UCI6@28211|Alphaproteobacteria,1FC2A@1060|Rhodobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1109692_2	1288298.rosmuc_03579	7.649e-115	390.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,46PRT@74030|Roseovarius	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
TLS3_k127_1109692_1	371731.Rsw2DRAFT_1104	1.497e-133	436.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2TS8U@28211|Alphaproteobacteria,1FB31@1060|Rhodobacter	28211|Alphaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
TLS3_k127_1109692_4	1188256.BASI01000003_gene2689	1.226e-31	125.0	COG0236@1|root,COG0236@2|Bacteria,1MZVG@1224|Proteobacteria,2UC3Q@28211|Alphaproteobacteria,3FEEH@34008|Rhodovulum	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS3_k127_1109692_0	1415756.JQMY01000001_gene2567	1.625e-184	584.0	COG0304@1|root,COG0304@2|Bacteria,1MV30@1224|Proteobacteria,2TRYK@28211|Alphaproteobacteria,2PD6E@252301|Oceanicola	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabF1	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS3_k127_1109692_3	195105.CN97_06125	6.543e-32	131.0	COG5342@1|root,COG5342@2|Bacteria,1NA8M@1224|Proteobacteria,2TSY3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	invasion associated locus B	MA20_19790	-	-	-	-	-	-	-	-	-	-	-	IalB
TLS3_k127_1111312_2	1446473.JHWH01000007_gene429	3.852e-81	290.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2PUPM@265|Paracoccus	28211|Alphaproteobacteria	Q	Zinc-dependent metalloprotease	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,PPC,Peptidase_M10,Peptidase_M10_C,Peptidase_M66,Reprolysin_4
TLS3_k127_1111312_0	1449351.RISW2_14365	1.713e-252	784.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2TSZY@28211|Alphaproteobacteria,4KM4E@93682|Roseivivax	28211|Alphaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS3_k127_1111312_1	1188256.BASI01000002_gene3249	4.569e-106	354.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,3FCHT@34008|Rhodovulum	28211|Alphaproteobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
TLS3_k127_1115558_1	314256.OG2516_13546	8.618e-103	340.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,2PCZZ@252301|Oceanicola	28211|Alphaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS3_k127_1115558_2	631454.N177_1134	4.596e-35	142.0	2CCJC@1|root,31PRJ@2|Bacteria,1R6D1@1224|Proteobacteria,2TV8P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1115558_3	314265.R2601_04808	1.15e-16	82.0	2DNVR@1|root,32ZDF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1115558_0	1122180.Lokhon_00568	9.785e-220	684.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2P810@245186|Loktanella	28211|Alphaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	adhC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0008150,GO:0008152,GO:0015945,GO:0034308,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901615	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_1120979_2	1449350.OCH239_11510	2.308e-30	133.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,4KMQE@93682|Roseivivax	28211|Alphaproteobacteria	C	Cytochrome c	cycA	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
TLS3_k127_1120979_0	195105.CN97_10280	7.783e-236	735.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
TLS3_k127_1120979_1	1122614.JHZF01000011_gene1513	1.466e-163	522.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,2PDUZ@252301|Oceanicola	28211|Alphaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS3_k127_1120979_3	935848.JAEN01000016_gene2397	5.488e-19	89.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,2PWCE@265|Paracoccus	28211|Alphaproteobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS3_k127_1126178_8	713587.THITH_07490	0.0009183	48.0	COG5342@1|root,COG5342@2|Bacteria,1N0W3@1224|Proteobacteria,1SGW7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Invasion associated locus B (IalB) protein	-	-	-	-	-	-	-	-	-	-	-	-	IalB
TLS3_k127_1126178_6	391937.NA2_09858	7.318e-51	188.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,43JYG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS3_k127_1126178_3	1502724.FF80_02995	5.685e-122	398.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,2TQTF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the bacterial solute-binding protein 9 family	sitA	-	-	ko:K02077,ko:K09815,ko:K11604	ko02010,map02010	M00242,M00244,M00317	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5,3.A.1.15.7,3.A.1.15.9	-	-	ZnuA
TLS3_k127_1126178_2	1381123.AYOD01000035_gene3353	1.219e-124	408.0	COG1121@1|root,COG1121@2|Bacteria,1MW47@1224|Proteobacteria,2TRJA@28211|Alphaproteobacteria,43I2U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	sitB	-	-	ko:K11607,ko:K11710	ko02010,map02010	M00317,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.7,3.A.1.15.9	-	-	ABC_tran
TLS3_k127_1126178_1	176299.Atu4469	6.22e-125	406.0	COG1108@1|root,COG1108@2|Bacteria,1MY5X@1224|Proteobacteria,2TQXB@28211|Alphaproteobacteria,4B7X2@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type Mn2 Zn2 transport systems, permease components	sitC	-	-	ko:K11605	ko02010,map02010	M00317	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.7,3.A.1.15.9	-	-	ABC-3
TLS3_k127_1126178_4	1231190.NA8A_14239	1.323e-86	295.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,43HW0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ABC 3 transport family	sitD	-	-	ko:K02075,ko:K11606,ko:K11708,ko:K11709	ko02010,map02010	M00244,M00317,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.7,3.A.1.15.9	-	-	ABC-3
TLS3_k127_1126178_7	311402.Avi_3899	4.529e-06	52.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,4B9SB@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS3_k127_1126178_5	420324.KI912043_gene4030	2.895e-64	228.0	COG0500@1|root,COG2226@2|Bacteria,1RKPU@1224|Proteobacteria,2UDN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_1126178_0	272943.RSP_0239	2.023e-130	417.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,1FAYP@1060|Rhodobacter	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS3_k127_1129083_4	349102.Rsph17025_3130	1.26e-38	147.0	COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,2U992@28211|Alphaproteobacteria,1FBY1@1060|Rhodobacter	28211|Alphaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
TLS3_k127_1129083_3	1461694.ATO9_03240	1.937e-53	195.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,2PE3B@252301|Oceanicola	28211|Alphaproteobacteria	CO	Thioredoxin-like	tlpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS3_k127_1129083_0	314264.ROS217_08655	1.922e-226	713.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,46PMZ@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0165 Argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
TLS3_k127_1129083_5	1449336.JQLO01000001_gene707	1.656e-21	106.0	COG1442@1|root,COG1442@2|Bacteria,1V2FM@1239|Firmicutes,4HFSG@91061|Bacilli,27H7K@186828|Carnobacteriaceae	91061|Bacilli	M	Glycosyl transferase family 8	gspA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0016740,GO:0016757,GO:0043170,GO:0044238,GO:0071704,GO:1901576	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
TLS3_k127_1129083_1	1449350.OCH239_11340	5.911e-217	681.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,4KKZV@93682|Roseivivax	28211|Alphaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS3_k127_1129083_2	1469613.JT55_09765	3.475e-188	617.0	COG0419@1|root,COG0419@2|Bacteria,1MWCT@1224|Proteobacteria,2TS61@28211|Alphaproteobacteria,3FCMF@34008|Rhodovulum	28211|Alphaproteobacteria	L	Domain of unknown function (DUF4175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
TLS3_k127_1160582_1	272943.RSP_1504	3.628e-36	139.0	2E36Z@1|root,32Y6R@2|Bacteria,1NCM6@1224|Proteobacteria,2UGU3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1160582_0	1122614.JHZF01000011_gene2258	2.967e-75	265.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,2PDSV@252301|Oceanicola	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_1160582_2	1123360.thalar_00096	1.604e-33	131.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_2,GST_N_3
TLS3_k127_1161268_0	349102.Rsph17025_0521	1.029e-241	761.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,1FARU@1060|Rhodobacter	28211|Alphaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
TLS3_k127_1161268_2	1125973.JNLC01000015_gene3347	2.989e-37	160.0	COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2TSVU@28211|Alphaproteobacteria,3K6KU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FR47-like protein	MA20_25245	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_1161268_3	1337093.MBE-LCI_1946	2.722e-06	53.0	COG0637@1|root,COG0637@2|Bacteria,1NF90@1224|Proteobacteria,2U9G8@28211|Alphaproteobacteria,2P9GZ@245186|Loktanella	28211|Alphaproteobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS3_k127_1161268_1	1120983.KB894571_gene2727	1.93e-48	179.0	COG0665@1|root,COG0665@2|Bacteria,1R79A@1224|Proteobacteria,2TVMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	ko:K02846	-	-	-	-	ko00000,ko01000	-	-	-	DAO
TLS3_k127_1163088_3	634452.APA01_23920	2.307e-56	198.0	COG5499@1|root,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,2U9KN@28211|Alphaproteobacteria,2JTPE@204441|Rhodospirillales	204441|Rhodospirillales	K	transcription regulator containing HTH domain	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3
TLS3_k127_1163088_4	1382303.JPOM01000001_gene2170	3.276e-43	161.0	COG4680@1|root,COG4680@2|Bacteria,1N036@1224|Proteobacteria,2UHXB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	HigB_toxin, RelE-like toxic component of a toxin-antitoxin system	-	-	-	ko:K19166	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HigB_toxin
TLS3_k127_1163088_1	1123360.thalar_03519	9.137e-78	268.0	COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Inositol monophosphatase	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS3_k127_1163088_0	398580.Dshi_0064	6.877e-183	584.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Zn-dependent proteases and their inactivated homologs	pmbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_1163088_2	351016.RAZWK3B_07124	6.541e-65	229.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,2P159@2433|Roseobacter	28211|Alphaproteobacteria	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_1166382_2	1432055.GLUCORHAEAF1_03420	7.052e-100	336.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,2TRM8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	MA20_13185	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_1166382_1	1500301.JQMF01000005_gene3961	2.447e-103	342.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria,4B76M@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
TLS3_k127_1166382_0	1410620.SHLA_78c000160	9.827e-305	945.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2TR12@28211|Alphaproteobacteria,4BDUK@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Thiamine pyrophosphate enzyme, central domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_1166382_3	195105.CN97_05545	1.112e-33	130.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS3_k127_1169062_2	1123229.AUBC01000005_gene762	1.075e-20	94.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2U1EE@28211|Alphaproteobacteria,3K63B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS3_k127_1169062_1	744980.TRICHSKD4_0493	1.949e-31	128.0	COG1846@1|root,COG1846@2|Bacteria,1NDQD@1224|Proteobacteria	1224|Proteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
TLS3_k127_1169062_0	1123229.AUBC01000005_gene759	0.0	1176.0	COG1018@1|root,COG1600@1|root,COG1018@2|Bacteria,COG1600@2|Bacteria,1MU6E@1224|Proteobacteria,2TRE9@28211|Alphaproteobacteria,3JSXZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	vanB	-	-	ko:K03863	ko00627,ko01120,map00627,map01120	-	R05274	RC00392,RC01533	ko00000,ko00001	-	-	-	Dehalogenase,FAD_binding_6,Fer2,Fer4_16,Fer4_7,NAD_binding_1
TLS3_k127_1170334_0	1336243.JAEA01000013_gene3269	7.405e-117	398.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,1JTVR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_1192417_2	1415756.JQMY01000001_gene647	1.316e-27	114.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,2PCH8@252301|Oceanicola	28211|Alphaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS3_k127_1192417_0	644107.SL1157_1393	3.771e-140	453.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria,4NBBK@97050|Ruegeria	28211|Alphaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
TLS3_k127_1192417_1	1449351.RISW2_11815	8.72e-33	130.0	2AH1R@1|root,317AV@2|Bacteria,1RGWA@1224|Proteobacteria,2U976@28211|Alphaproteobacteria,4KMTT@93682|Roseivivax	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1192417_3	395965.Msil_2344	2.168e-07	62.0	COG3861@1|root,COG3861@2|Bacteria,1RD6Y@1224|Proteobacteria,2U683@28211|Alphaproteobacteria,3NB1S@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS3_k127_1193035_3	1530186.JQEY01000002_gene1596	1.254e-08	58.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS3_k127_1193035_0	1469613.JT55_18920	1.645e-108	363.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,3FD1X@34008|Rhodovulum	28211|Alphaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
TLS3_k127_1193035_1	1317118.ATO8_03806	1.706e-106	352.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,4KK9T@93682|Roseivivax	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
TLS3_k127_1193035_2	1188256.BASI01000002_gene3185	1.19e-68	239.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2TREW@28211|Alphaproteobacteria,3FCWZ@34008|Rhodovulum	28211|Alphaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
TLS3_k127_1215443_1	1337093.MBE-LCI_3495	1.785e-70	246.0	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,2U56J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Gluconate 2-dehydrogenase	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3,TAT_signal
TLS3_k127_1215443_0	1337093.MBE-LCI_3496	4.768e-307	950.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2P9XZ@245186|Loktanella	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.3	ko:K06151	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_1220113_6	663610.JQKO01000001_gene603	9.315e-10	62.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,3N9T3@45404|Beijerinckiaceae	28211|Alphaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS3_k127_1220113_3	1415756.JQMY01000001_gene1694	2.782e-46	168.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,2PEB8@252301|Oceanicola	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS3_k127_1220113_4	1294273.roselon_00461	3.089e-14	82.0	COG5416@1|root,COG5416@2|Bacteria	2|Bacteria	FG	Lipopolysaccharide assembly protein A domain	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
TLS3_k127_1220113_1	1121271.AUCM01000006_gene351	2.298e-79	270.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
TLS3_k127_1220113_2	1449350.OCH239_05205	2.178e-62	224.0	COG2931@1|root,COG2931@2|Bacteria,1QVK6@1224|Proteobacteria,2TWH2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Domain of unknown function (DUF4394)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4394
TLS3_k127_1220113_0	1294273.roselon_00458	2.388e-236	739.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_1220113_5	1317124.DW2_12215	2.477e-13	76.0	2E7WN@1|root,332B9@2|Bacteria,1NAX9@1224|Proteobacteria,2UG5A@28211|Alphaproteobacteria,2XPH1@285107|Thioclava	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1249075_1	314264.ROS217_15006	3.312e-30	119.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,46NII@74030|Roseovarius	28211|Alphaproteobacteria	F	COG0505 Carbamoylphosphate synthase small subunit	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS3_k127_1249075_0	1123229.AUBC01000001_gene1613	2.848e-164	540.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,3JTYR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0061 (SELO) family	MA20_28420	-	-	-	-	-	-	-	-	-	-	-	UPF0061
TLS3_k127_1249075_2	1459636.NTE_00040	3.794e-20	103.0	arCOG09466@1|root,arCOG09466@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1249417_7	1082932.ATCR1_14761	2.048e-14	81.0	COG3103@1|root,COG3103@2|Bacteria,1N82Q@1224|Proteobacteria,2UMU5@28211|Alphaproteobacteria,4BKTS@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS3_k127_1249417_4	1120983.KB894571_gene2493	1.919e-47	177.0	COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,2U7JU@28211|Alphaproteobacteria,1JQ3Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
TLS3_k127_1249417_0	420662.Mpe_A3522	1.184e-147	476.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1KK27@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1249417_6	290397.Adeh_2222	1.732e-28	124.0	COG1977@1|root,COG1977@2|Bacteria,1N6RG@1224|Proteobacteria,43BB8@68525|delta/epsilon subdivisions,2X6QE@28221|Deltaproteobacteria,2YVUR@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
TLS3_k127_1249417_1	666509.RCA23_c14110	2.315e-106	355.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS3_k127_1249417_3	1188256.BASI01000003_gene2874	2.474e-85	288.0	COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2V98F@28211|Alphaproteobacteria,3FDKI@34008|Rhodovulum	28211|Alphaproteobacteria	E	Peptidase family M48	-	-	-	ko:K07387	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M48
TLS3_k127_1249417_5	1353537.TP2_12775	3.759e-44	164.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria,2XNCS@285107|Thioclava	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	erpA	-	-	ko:K13628,ko:K15724	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS3_k127_1249417_2	1122180.Lokhon_00304	1.498e-91	312.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,2P8NT@245186|Loktanella	28211|Alphaproteobacteria	F	Phosphohydrolase-associated domain	dgt	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS3_k127_1249708_4	1410620.SHLA_14c000110	1.474e-36	151.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BDAQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_1249708_0	349102.Rsph17025_1598	3.335e-279	865.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,1FBFT@1060|Rhodobacter	28211|Alphaproteobacteria	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS3_k127_1249708_3	1101191.KI912577_gene1300	8.754e-58	211.0	COG1028@1|root,COG1028@2|Bacteria,1RAEZ@1224|Proteobacteria,2U7DM@28211|Alphaproteobacteria,1JT55@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	csgA	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS3_k127_1249708_1	351016.RAZWK3B_11126	6.916e-215	691.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2TQP6@28211|Alphaproteobacteria,2P2JE@2433|Roseobacter	28211|Alphaproteobacteria	S	protein related to deoxyribodipyrimidine photolyase	phrB	GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP,FAD_binding_7
TLS3_k127_1249708_5	349102.Rsph17025_0891	2.294e-16	84.0	COG3027@1|root,COG3027@2|Bacteria,1N8NY@1224|Proteobacteria,2UCRX@28211|Alphaproteobacteria,1FC2C@1060|Rhodobacter	28211|Alphaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	MA20_17980	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
TLS3_k127_1249708_2	935848.JAEN01000014_gene1703	1.538e-154	490.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,2PUZB@265|Paracoccus	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS3_k127_1269052_2	1208323.B30_05881	3.319e-19	89.0	COG2390@1|root,COG2390@2|Bacteria,1Q5SS@1224|Proteobacteria,2U1K4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG2390 Transcriptional regulator contains sigma factor-related N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_38,Sigma70_r4_2,Sugar-bind
TLS3_k127_1269052_0	314256.OG2516_07056	1.055e-142	460.0	COG3684@1|root,COG3684@2|Bacteria,1R4PC@1224|Proteobacteria,2U32Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	DeoC/LacD family aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS3_k127_1269052_1	1122963.AUHB01000010_gene1607	9.27e-70	247.0	COG1940@1|root,COG1940@2|Bacteria,1RAIC@1224|Proteobacteria,2U65E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	Transcriptional regulator sugar kinase	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_33,ROK
TLS3_k127_1269052_3	314256.OG2516_07046	2.475e-08	65.0	COG0645@1|root,COG0645@2|Bacteria,1QYQ1@1224|Proteobacteria,2TXV7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_129035_2	1367847.JCM7686_3432	4.83e-65	237.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria,2PVF4@265|Paracoccus	28211|Alphaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
TLS3_k127_129035_1	296591.Bpro_2492	6.899e-69	258.0	COG0477@1|root,COG2814@2|Bacteria,1MX4G@1224|Proteobacteria,2VJ3X@28216|Betaproteobacteria,4AG5N@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_129035_0	1054213.HMPREF9946_02640	3.363e-213	678.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JQH0@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K21134	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27	-	-	ACR_tran
TLS3_k127_129254_5	1123237.Salmuc_02167	4.457e-74	253.0	2E3HM@1|root,32EQI@2|Bacteria,1NGRR@1224|Proteobacteria,2UK11@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_129254_7	395495.Lcho_1986	4.866e-19	91.0	COG2010@1|root,COG2010@2|Bacteria,1N5Y7@1224|Proteobacteria,2VYS0@28216|Betaproteobacteria,1KNM4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_129254_0	398580.Dshi_2733	1.001e-181	584.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S1C family	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
TLS3_k127_129254_8	492774.JQMB01000004_gene2045	0.0001508	50.0	COG3242@1|root,COG3242@2|Bacteria,1NGPZ@1224|Proteobacteria,2V8YZ@28211|Alphaproteobacteria,4BH4I@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
TLS3_k127_129254_3	1121479.AUBS01000008_gene986	3.97e-106	359.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
TLS3_k127_129254_2	1461693.ATO10_11132	6.203e-135	440.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
TLS3_k127_129254_1	1188256.BASI01000005_gene2101	5.722e-163	540.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,3FCRD@34008|Rhodovulum	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	gor	GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_129254_6	1449350.OCH239_08490	5.51e-69	242.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,4KM9C@93682|Roseivivax	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
TLS3_k127_129254_4	1305735.JAFT01000005_gene2903	1.279e-84	289.0	COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2TR3D@28211|Alphaproteobacteria,2PDFK@252301|Oceanicola	28211|Alphaproteobacteria	E	Serine dehydratase beta chain	sdaA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
TLS3_k127_13224_2	349102.Rsph17025_1089	4.727e-88	298.0	COG3391@1|root,COG3391@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,1FCI5@1060|Rhodobacter	28211|Alphaproteobacteria	S	GTA TIM-barrel-like domain	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM,Phage-tail_3
TLS3_k127_13224_5	89187.ISM_05205	1.984e-54	196.0	COG0791@1|root,COG0791@2|Bacteria,1RK6X@1224|Proteobacteria,2U93K@28211|Alphaproteobacteria,46QT5@74030|Roseovarius	28211|Alphaproteobacteria	M	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
TLS3_k127_13224_1	1469613.JT55_04060	1.355e-91	319.0	COG5449@1|root,COG5449@2|Bacteria,1MXK2@1224|Proteobacteria,2TTWS@28211|Alphaproteobacteria,3FD28@34008|Rhodovulum	28211|Alphaproteobacteria	S	Phage conserved hypothetical protein BR0599	-	-	-	-	-	-	-	-	-	-	-	-	DUF2163,Phage_BR0599
TLS3_k127_13224_0	1123247.AUIJ01000006_gene3302	5.695e-92	306.0	COG5448@1|root,COG5448@2|Bacteria,1MXM8@1224|Proteobacteria,2TTJ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycoside hydrolase family 24	-	-	-	-	-	-	-	-	-	-	-	-	DUF2460
TLS3_k127_13224_3	1469613.JT55_04050	1.333e-60	218.0	COG5281@1|root,COG5281@2|Bacteria,1R47M@1224|Proteobacteria,2TUIV@28211|Alphaproteobacteria,3FDD5@34008|Rhodovulum	28211|Alphaproteobacteria	S	COG5281, Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_13224_10	1525715.IX54_07095	8.357e-14	79.0	2E2Z2@1|root,32XZR@2|Bacteria,1NA9J@1224|Proteobacteria,2UFQ5@28211|Alphaproteobacteria,2PXT5@265|Paracoccus	28211|Alphaproteobacteria	S	Phage tail assembly chaperone protein, TAC	-	-	-	-	-	-	-	-	-	-	-	-	Phage_TAC_6
TLS3_k127_13224_8	1288298.rosmuc_03453	7.621e-28	125.0	2CN1W@1|root,32SG3@2|Bacteria,1N0IV@1224|Proteobacteria,2UC9F@28211|Alphaproteobacteria,46R2N@74030|Roseovarius	28211|Alphaproteobacteria	S	Phage tail tube protein, GTA-gp10	-	-	-	-	-	-	-	-	-	-	-	-	Phage_TAC_11
TLS3_k127_13224_4	1294273.roselon_02418	1.657e-59	217.0	COG5437@1|root,COG5437@2|Bacteria,1RH1Z@1224|Proteobacteria,2U9I4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Major tail protein, TP901-1 family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_tail_2
TLS3_k127_13224_9	391613.RTM1035_10710	6.091e-24	112.0	2DE8C@1|root,32U2V@2|Bacteria,1MZH7@1224|Proteobacteria,2UBWF@28211|Alphaproteobacteria,46QV6@74030|Roseovarius	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3168)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3168
TLS3_k127_13224_7	1288298.rosmuc_03450	7.429e-29	127.0	COG5614@1|root,COG5614@2|Bacteria,1N0CB@1224|Proteobacteria,2UBY8@28211|Alphaproteobacteria,46R39@74030|Roseovarius	28211|Alphaproteobacteria	S	Phage head-tail joining protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_H_T_join
TLS3_k127_13224_6	1353528.DT23_03825	5.138e-50	187.0	2CK39@1|root,32SBG@2|Bacteria,1MZ6F@1224|Proteobacteria,2VA7T@28211|Alphaproteobacteria,2XN9S@285107|Thioclava	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_13224_11	1234595.C725_2198	9.186e-06	53.0	2DSDE@1|root,33FMS@2|Bacteria,1NADE@1224|Proteobacteria,2UJ2C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1353159_2	501479.ACNW01000102_gene765	1.135e-29	131.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_1353159_0	1207063.P24_04335	1.508e-81	282.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2U6B7@28211|Alphaproteobacteria,2JSUM@204441|Rhodospirillales	204441|Rhodospirillales	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
TLS3_k127_1353159_1	1294273.roselon_00664	2.254e-66	237.0	COG2813@1|root,COG2813@2|Bacteria,1MXE9@1224|Proteobacteria,2TSBA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	16S RNA G1207 methylase RsmC	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS,MTS_N
TLS3_k127_1361566_3	1417296.U879_02390	8.571e-35	137.0	2DMIX@1|root,32RWA@2|Bacteria,1N0KH@1224|Proteobacteria,2UBZ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1361566_0	59538.XP_005964086.1	2.933e-220	691.0	COG0015@1|root,KOG2700@2759|Eukaryota,38D20@33154|Opisthokonta,3BDAF@33208|Metazoa,3CY7E@33213|Bilateria,4870P@7711|Chordata,4903F@7742|Vertebrata,3JEST@40674|Mammalia,4J2TD@91561|Cetartiodactyla	33208|Metazoa	F	adenylosuccinate lyase	-	-	-	-	-	-	-	-	-	-	-	-	ADSL_C,Lyase_1
TLS3_k127_1361566_2	1121861.KB899912_gene1109	1.071e-54	197.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2TU17@28211|Alphaproteobacteria,2JSXW@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TLS3_k127_1361566_1	985054.JQEZ01000001_gene1908	6.417e-127	418.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,4N9TZ@97050|Ruegeria	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
TLS3_k127_1378558_8	1280954.HPO_07382	9.024e-55	211.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,2U97D@28211|Alphaproteobacteria,43ZDD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
TLS3_k127_1378558_3	1280953.HOC_10084	1.659e-114	378.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,2TQS6@28211|Alphaproteobacteria,43ZKF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
TLS3_k127_1378558_2	1121028.ARQE01000010_gene983	9.261e-124	403.0	COG4813@1|root,COG4813@2|Bacteria,1P43S@1224|Proteobacteria,2TUH4@28211|Alphaproteobacteria,2PJCX@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Trehalose utilisation	thuA	-	-	-	-	-	-	-	-	-	-	-	ThuA
TLS3_k127_1378558_0	1121028.ARQE01000010_gene982	3.335e-141	473.0	COG0673@1|root,COG0673@2|Bacteria,1NVIW@1224|Proteobacteria,2U0QQ@28211|Alphaproteobacteria,2PJCE@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_1378558_9	1469613.JT55_09880	5.194e-31	135.0	COG4392@1|root,COG4392@2|Bacteria,1MZUZ@1224|Proteobacteria,2UC31@28211|Alphaproteobacteria,3FEDS@34008|Rhodovulum	28211|Alphaproteobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS3_k127_1378558_5	1469613.JT55_09875	6.867e-71	248.0	COG1296@1|root,COG1296@2|Bacteria,1MVGN@1224|Proteobacteria,2TVIA@28211|Alphaproteobacteria,3FDHB@34008|Rhodovulum	28211|Alphaproteobacteria	E	AzlC protein	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
TLS3_k127_1378558_1	1288298.rosmuc_03228	9.096e-137	440.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VFYH@28211|Alphaproteobacteria,46PK3@74030|Roseovarius	28211|Alphaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS3_k127_1378558_6	1317118.ATO8_06401	9.679e-69	250.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2TV2G@28211|Alphaproteobacteria,4KMR3@93682|Roseivivax	28211|Alphaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS3_k127_1378558_7	1449350.OCH239_07330	8.548e-61	225.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2U5T0@28211|Alphaproteobacteria,4KMVM@93682|Roseivivax	28211|Alphaproteobacteria	H	Molybdopterin-guanine dinucleotide biosynthesis protein	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
TLS3_k127_1378558_4	252305.OB2597_10249	2.533e-75	274.0	COG2082@1|root,COG2082@2|Bacteria,1MX1E@1224|Proteobacteria,2TRRB@28211|Alphaproteobacteria,2PCVV@252301|Oceanicola	28211|Alphaproteobacteria	H	Precorrin-8X methylmutase	cobH	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC
TLS3_k127_1378558_10	388399.SSE37_20037	2.457e-05	57.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS3_k127_1386758_2	69279.BG36_22250	5.361e-78	270.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2U7DN@28211|Alphaproteobacteria,43I3S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Bacterial sugar transferase	exoY	-	2.7.8.6	ko:K00996,ko:K16566	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf
TLS3_k127_1386758_0	1408224.SAMCCGM7_c3776	5.415e-119	397.0	COG1596@1|root,COG1596@2|Bacteria,1RA89@1224|Proteobacteria,2U81D@28211|Alphaproteobacteria,4BM9W@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991,ko:K16552	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18,1.B.18.1	-	-	Poly_export,SLBB
TLS3_k127_1386758_1	1040983.AXAE01000004_gene744	1.256e-101	342.0	COG0463@1|root,COG0463@2|Bacteria,1QVEG@1224|Proteobacteria,2TWDH@28211|Alphaproteobacteria,43RRK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_1,Glycos_transf_2
TLS3_k127_1422710_0	351016.RAZWK3B_03935	5.785e-138	451.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2TRDH@28211|Alphaproteobacteria,2P2HY@2433|Roseobacter	28211|Alphaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
TLS3_k127_1422710_1	420324.KI912045_gene4539	2.471e-92	305.0	COG0262@1|root,COG0262@2|Bacteria,1MY3I@1224|Proteobacteria,2U3DT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS3_k127_1422710_2	1305735.JAFT01000005_gene893	3.573e-33	136.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2UFKH@28211|Alphaproteobacteria,2PES1@252301|Oceanicola	28211|Alphaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS3_k127_1422710_3	1461693.ATO10_04192	1.062e-30	127.0	COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2UFAB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS3_k127_1445408_4	314265.R2601_20671	1.685e-31	139.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria	2|Bacteria	K	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS3_k127_1445408_1	272943.RSP_2621	7.776e-138	440.0	COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria,1FAVQ@1060|Rhodobacter	28211|Alphaproteobacteria	K	Two component transcriptional regulator, winged helix family	ctrA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K02483,ko:K13584	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_1445408_5	272943.RSP_2620	3.593e-23	115.0	2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,1FC22@1060|Rhodobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1153)	MA20_11245	-	-	-	-	-	-	-	-	-	-	-	DUF1153
TLS3_k127_1445408_0	195105.CN97_00520	1.017e-178	567.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS3_k127_1445408_2	1122218.KB893653_gene529	6.398e-91	310.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,1JSAV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
TLS3_k127_1445408_3	1231392.OCGS_2084	5.437e-42	156.0	COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,2UC11@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_03865	-	-	ko:K09948	-	-	-	-	ko00000	-	-	-	DUF1244
TLS3_k127_1470601_0	314264.ROS217_07625	3.869e-63	228.0	COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,2UDFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_1470601_2	314262.MED193_18094	1.107e-53	196.0	COG2227@1|root,COG2227@2|Bacteria,1RKPN@1224|Proteobacteria,2UB0I@28211|Alphaproteobacteria,2P4NG@2433|Roseobacter	28211|Alphaproteobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1470601_1	768671.ThimaDRAFT_4739	3.407e-55	209.0	COG4424@1|root,COG4424@2|Bacteria,1N77D@1224|Proteobacteria,1SB49@1236|Gammaproteobacteria,1WZDB@135613|Chromatiales	135613|Chromatiales	S	PFAM sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS3_k127_1470601_3	266809.PM03_05355	1.041e-20	102.0	2E26U@1|root,32XD7@2|Bacteria,1N67M@1224|Proteobacteria,2UCXU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1480203_2	395495.Lcho_3046	7.291e-61	218.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,2VJGX@28216|Betaproteobacteria,1KMR6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
TLS3_k127_1480203_0	395495.Lcho_3047	9.868e-106	379.0	COG1874@1|root,COG4385@1|root,COG1874@2|Bacteria,COG4385@2|Bacteria,1NEK3@1224|Proteobacteria,2VR29@28216|Betaproteobacteria,1KNB8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	TIGRFAM phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
TLS3_k127_1480203_3	1449076.JOOE01000003_gene3264	7.265e-28	132.0	29FGY@1|root,302EK@2|Bacteria,1PV9V@1224|Proteobacteria,2V1PR@28211|Alphaproteobacteria,2KBUI@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1480203_1	864051.BurJ1DRAFT_2329	2.411e-92	335.0	COG1196@1|root,COG1196@2|Bacteria,1R8NC@1224|Proteobacteria,2VX0P@28216|Betaproteobacteria,1KN4I@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1480203_4	483219.LILAB_30600	7.09e-10	68.0	COG0845@1|root,COG0845@2|Bacteria,1R7QT@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1487198_3	411684.HPDFL43_14972	8.102e-23	105.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,43KPD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS3_k127_1487198_4	411684.HPDFL43_14972	3.751e-17	89.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,43KPD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS3_k127_1487198_2	1242969.ATCC51562_1183	9.188e-26	118.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42M5H@68525|delta/epsilon subdivisions,2YMZE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Pfam matches to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
TLS3_k127_1487198_0	1122135.KB893136_gene559	2.567e-219	685.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_1487198_1	272630.MexAM1_META1p4542	1.09e-123	405.0	COG0491@1|root,COG0491@2|Bacteria,1Q861@1224|Proteobacteria,2U29C@28211|Alphaproteobacteria,1JT0M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_149953_0	1121271.AUCM01000003_gene1765	4.034e-238	751.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_149953_6	1231392.OCGS_0050	2.415e-16	89.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	UPF0056 membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TLS3_k127_149953_2	1469613.JT55_04670	6.993e-62	229.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,3FE0W@34008|Rhodovulum	28211|Alphaproteobacteria	U	MarC family integral membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TLS3_k127_149953_5	292414.TM1040_0952	1.671e-43	166.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VG8P@28211|Alphaproteobacteria,4NBTK@97050|Ruegeria	28211|Alphaproteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
TLS3_k127_149953_3	34007.IT40_17045	2.099e-54	201.0	COG1309@1|root,COG1309@2|Bacteria,1PDYH@1224|Proteobacteria,2V7WH@28211|Alphaproteobacteria,2PY0D@265|Paracoccus	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_149953_4	570967.JMLV01000015_gene3063	6.957e-46	170.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,2JSSV@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
TLS3_k127_149953_1	1211115.ALIQ01000015_gene2282	8.097e-70	244.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria,3NBAH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS3_k127_1517710_4	269796.Rru_A0536	1.647e-26	120.0	COG2207@1|root,COG2207@2|Bacteria,1RJPK@1224|Proteobacteria,2TVEN@28211|Alphaproteobacteria,2JS94@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
TLS3_k127_1517710_1	1121124.JNIX01000007_gene566	1.835e-187	592.0	28JCT@1|root,2Z97C@2|Bacteria,1R738@1224|Proteobacteria,2U3ED@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1517710_3	349102.Rsph17025_1096	1.636e-154	513.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,2TSQD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
TLS3_k127_1517710_2	439497.RR11_1736	2.332e-175	565.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,4NAXJ@97050|Ruegeria	28211|Alphaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS3_k127_1517710_0	1417296.U879_20260	2.821e-313	972.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS3_k127_1526071_1	349102.Rsph17025_2947	3.054e-130	420.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	JM	Glucose-1-phosphate cytidylyltransferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
TLS3_k127_1526071_0	426117.M446_4971	4.723e-151	484.0	COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,2TTV7@28211|Alphaproteobacteria,1JRA5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_1526071_4	1001240.GY21_08450	2.507e-34	152.0	2CANE@1|root,33385@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1526071_2	1166948.JPZL01000001_gene2800	5.911e-64	228.0	COG1898@1|root,COG1898@2|Bacteria,1RDAB@1224|Proteobacteria,1S5T5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS3_k127_1526071_5	395963.Bind_1653	3.781e-33	133.0	COG2361@1|root,COG2361@2|Bacteria,1PTAJ@1224|Proteobacteria,2UMAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
TLS3_k127_1526071_6	1158292.JPOE01000002_gene3494	6.098e-31	124.0	COG1669@1|root,COG1669@2|Bacteria,1N17I@1224|Proteobacteria,2VVYD@28216|Betaproteobacteria,1KMRY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
TLS3_k127_1526071_3	365046.Rta_24850	2.372e-43	170.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VQM9@28216|Betaproteobacteria,4ADI3@80864|Comamonadaceae	28216|Betaproteobacteria	E	homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_3
TLS3_k127_1535892_5	290400.Jann_0617	1.239e-50	179.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
TLS3_k127_1535892_4	1123237.Salmuc_01552	1.789e-63	222.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS3_k127_1535892_2	396588.Tgr7_2570	8.12e-85	284.0	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,1S7W4@1236|Gammaproteobacteria,1WZVN@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS3_k127_1535892_0	570952.ATVH01000017_gene1763	1.846e-144	466.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TLS3_k127_1535892_1	272943.RSP_2660	2.15e-114	388.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,1FBYC@1060|Rhodobacter	28211|Alphaproteobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS3_k127_1535892_3	1317124.DW2_06358	2.48e-82	277.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2XMKF@285107|Thioclava	28211|Alphaproteobacteria	O	ATPase (AAA	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS3_k127_1547634_1	1282876.BAOK01000001_gene1001	7.472e-120	393.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
TLS3_k127_1547634_3	195105.CN97_00415	9.771e-107	352.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS3_k127_1547634_5	1116369.KB890024_gene3733	3.189e-81	276.0	COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2TRHY@28211|Alphaproteobacteria,43HBQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS3_k127_1547634_2	272943.RSP_2242	1.576e-116	390.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,1FBIQ@1060|Rhodobacter	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS3_k127_1547634_6	349102.Rsph17025_2253	1.75e-27	123.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2UBU3@28211|Alphaproteobacteria,1FBXX@1060|Rhodobacter	28211|Alphaproteobacteria	F	PFAM phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
TLS3_k127_1547634_0	398580.Dshi_1761	2.286e-123	411.0	COG0204@1|root,COG0204@2|Bacteria,1QU3F@1224|Proteobacteria,2U1AI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS3_k127_1547634_4	1449351.RISW2_21430	9.144e-91	306.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,4KM27@93682|Roseivivax	28211|Alphaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
TLS3_k127_1550888_4	1122614.JHZF01000011_gene824	5.4e-38	144.0	COG3502@1|root,COG3502@2|Bacteria,1MZEQ@1224|Proteobacteria,2UBR3@28211|Alphaproteobacteria,2PEHP@252301|Oceanicola	28211|Alphaproteobacteria	S	Protein of unknown function (DUF952)	MA20_22095	-	-	-	-	-	-	-	-	-	-	-	DUF952
TLS3_k127_1550888_2	272943.RSP_0957	1.074e-141	462.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,1FAPH@1060|Rhodobacter	28211|Alphaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS3_k127_1550888_3	359.CN09_03190	6.157e-57	202.0	COG4101@1|root,COG4101@2|Bacteria,1RIFZ@1224|Proteobacteria,2UER9@28211|Alphaproteobacteria,4BDZP@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_1550888_1	1411123.JQNH01000001_gene662	3.255e-160	526.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na phosphate symporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
TLS3_k127_1550888_0	1417296.U879_02890	1.082e-165	529.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,2TSKZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG0534 Na -driven multidrug efflux pump	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_156654_0	1121271.AUCM01000003_gene1737	7.801e-96	329.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	MA20_30780	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_156654_1	1353528.DT23_04270	1.229e-50	185.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,2XNAV@285107|Thioclava	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_1589709_1	1188256.BASI01000003_gene2512	7.84e-155	499.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,3FCJ1@34008|Rhodovulum	28211|Alphaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS3_k127_1589709_2	398580.Dshi_1753	2.36e-109	359.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS3_k127_1589709_5	1121271.AUCM01000012_gene2969	3.213e-36	157.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS3_k127_1589709_0	1231392.OCGS_2417	2.936e-295	928.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS3_k127_1589709_4	290400.Jann_2333	2.504e-38	160.0	29KAU@1|root,30784@2|Bacteria,1RCW8@1224|Proteobacteria,2U783@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Holin of 3TMs, for gene-transfer release	-	-	-	-	-	-	-	-	-	-	-	-	GTA_holin_3TM
TLS3_k127_1589709_3	1525715.IX54_12345	1.755e-85	288.0	COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2TT3H@28211|Alphaproteobacteria,2PUCH@265|Paracoccus	28211|Alphaproteobacteria	S	Predicted Peptidoglycan domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
TLS3_k127_1594438_1	1907.SGLAU_11530	4.33e-10	63.0	COG1404@1|root,COG1404@2|Bacteria,2IBFK@201174|Actinobacteria	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS3_k127_1594438_0	349102.Rsph17025_0864	2.061e-196	623.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,1FBJG@1060|Rhodobacter	28211|Alphaproteobacteria	E	PFAM Glutamine synthetase, catalytic	glnA1	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS3_k127_1595379_1	991905.SL003B_0542	7.853e-93	308.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VFXG@28211|Alphaproteobacteria,4BPWS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Isocitrate/isopropylmalate dehydrogenase	-	GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576	1.1.1.42,1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73	ko:K00031,ko:K00052,ko:K07246	ko00020,ko00290,ko00480,ko00630,ko00650,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00630,map00650,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00432,M00535,M00740	R00215,R00267,R00268,R00994,R01751,R01899,R02545,R04426,R06180,R10052	RC00001,RC00084,RC00105,RC00114,RC00417,RC00594,RC00626,RC02801,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS3_k127_1595379_0	1121271.AUCM01000028_gene66	7.763e-187	590.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	5.3.2.8	ko:K16514	ko00362,ko01120,map00362,map01120	-	R07839	RC02426	ko00000,ko00001,ko01000	-	-	-	PrpF
TLS3_k127_1595379_2	1449351.RISW2_03305	2.269e-31	124.0	COG1052@1|root,COG1052@2|Bacteria,1QVZS@1224|Proteobacteria,2TUUQ@28211|Alphaproteobacteria,4KMKF@93682|Roseivivax	28211|Alphaproteobacteria	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_1596969_2	1211115.ALIQ01000196_gene69	5.525e-170	571.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2TSNH@28211|Alphaproteobacteria,3NCBZ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_1596969_8	1120705.FG95_01291	4.701e-67	232.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2U735@28211|Alphaproteobacteria,2K4WC@204457|Sphingomonadales	204457|Sphingomonadales	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS3_k127_1596969_0	1101189.AQUO01000002_gene855	4.79e-248	774.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2PUHK@265|Paracoccus	28211|Alphaproteobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS3_k127_1596969_6	633149.Bresu_1031	2.239e-88	297.0	COG5485@1|root,COG5485@2|Bacteria,1NG9D@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS3_k127_1596969_9	633149.Bresu_1030	5.557e-59	211.0	COG1309@1|root,COG1309@2|Bacteria,1N6WG@1224|Proteobacteria,2UG93@28211|Alphaproteobacteria,2KJZP@204458|Caulobacterales	204458|Caulobacterales	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
TLS3_k127_1596969_5	1417296.U879_02320	5.652e-100	333.0	COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,2TR8U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG1349 Transcriptional regulators of sugar metabolism	glpR	-	-	ko:K02444	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS3_k127_1596969_4	1317118.ATO8_14957	1.919e-102	354.0	COG0697@1|root,COG0697@2|Bacteria,1NDKG@1224|Proteobacteria,2U0DF@28211|Alphaproteobacteria,4KN6J@93682|Roseivivax	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
TLS3_k127_1596969_1	1354722.JQLS01000008_gene2853	6.914e-188	602.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,46Q0S@74030|Roseovarius	28211|Alphaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_1596969_7	1082933.MEA186_34594	9.641e-86	310.0	COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2TS8F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
TLS3_k127_1596969_3	1121479.AUBS01000019_gene2864	4.306e-112	376.0	COG0665@1|root,COG0665@2|Bacteria,1MXD1@1224|Proteobacteria,2TTDG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS3_k127_1596969_10	1122614.JHZF01000013_gene3011	1.624e-19	93.0	COG0454@1|root,COG0456@2|Bacteria,1RCBE@1224|Proteobacteria,2U1JB@28211|Alphaproteobacteria,2PE8Q@252301|Oceanicola	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	yobR	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_1609807_2	667632.KB890217_gene4884	4.103e-54	209.0	COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2VNZ3@28216|Betaproteobacteria,1K3AE@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS3_k127_1609807_0	571166.KI421509_gene2252	5.805e-140	453.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	hpaG	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS3_k127_1609807_1	272943.RSP_0174	7.935e-96	334.0	COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria,1FCNT@1060|Rhodobacter	28211|Alphaproteobacteria	IQ	short-chain dehydrogenase	MA20_27190	-	1.1.1.30	ko:K00019,ko:K18335	ko00051,ko00072,ko00650,ko01100,ko01120,map00051,map00072,map00650,map01100,map01120	M00088	R01361,R10690	RC00089,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
TLS3_k127_1609807_5	266834.SM_b20590	7.964e-21	101.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,4BG64@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	acylphosphatase	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS3_k127_1609807_3	1469613.JT55_17155	6.588e-50	186.0	COG1564@1|root,COG1564@2|Bacteria,1RE29@1224|Proteobacteria,2U7FB@28211|Alphaproteobacteria,3FE22@34008|Rhodovulum	28211|Alphaproteobacteria	H	Thiamin pyrophosphokinase, vitamin B1 binding domain	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
TLS3_k127_1609807_4	1395571.TMS3_0106785	6.421e-43	158.0	COG3045@1|root,COG3045@2|Bacteria,1RDMP@1224|Proteobacteria,1S29X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	creA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05805	-	-	-	-	ko00000	-	-	-	CreA
TLS3_k127_1648794_1	1449351.RISW2_18605	2.503e-70	245.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria,4KKPH@93682|Roseivivax	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS3_k127_1648794_0	1415756.JQMY01000001_gene302	6.473e-170	543.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,2PD22@252301|Oceanicola	28211|Alphaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	ccrM	-	2.1.1.72	ko:K13581	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko02048	-	-	-	N6_N4_Mtase
TLS3_k127_1651060_2	1123229.AUBC01000001_gene1720	9.55e-138	444.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria,3JSPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
TLS3_k127_1651060_4	391937.NA2_01380	5.508e-52	190.0	29PQU@1|root,31QPX@2|Bacteria,1RKRW@1224|Proteobacteria,2UB5U@28211|Alphaproteobacteria,43KIU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
TLS3_k127_1651060_3	1380391.JIAS01000011_gene4712	2.844e-69	246.0	COG0583@1|root,COG0583@2|Bacteria,1R51E@1224|Proteobacteria,2TZIK@28211|Alphaproteobacteria,2JX1S@204441|Rhodospirillales	204441|Rhodospirillales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_1651060_0	391595.RLO149_c024530	3.449e-178	579.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,2P2N5@2433|Roseobacter	28211|Alphaproteobacteria	S	COG3552 Protein containing von Willebrand factor type A (vWA) domain	MA20_09405	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_1651060_5	1168059.KB899087_gene4324	9.967e-29	119.0	2CWCM@1|root,32SZF@2|Bacteria,1N037@1224|Proteobacteria,2UCWU@28211|Alphaproteobacteria,3F1T6@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4260)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4260
TLS3_k127_1651060_1	1380367.JIBC01000006_gene572	2.788e-152	485.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,3ZWC4@60136|Sulfitobacter	28211|Alphaproteobacteria	S	AAA domain (dynein-related subfamily)	MA20_09400	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS3_k127_1653009_0	1123237.Salmuc_01214	2.991e-229	719.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS3_k127_1653009_1	1530186.JQEY01000008_gene3067	7.059e-98	328.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	ptr1	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS3_k127_1653009_2	1417296.U879_02465	5.426e-94	316.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TQZP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	COG0616 periplasmic serine proteases (ClpP class)	sohB	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS3_k127_1663490_4	314256.OG2516_05433	1.709e-26	113.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,2PEHJ@252301|Oceanicola	28211|Alphaproteobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
TLS3_k127_1663490_1	1305735.JAFT01000005_gene3283	1.796e-54	199.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria,2PE7J@252301|Oceanicola	28211|Alphaproteobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS3_k127_1663490_3	1417296.U879_12050	7.596e-36	136.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS3_k127_1663490_0	398580.Dshi_2188	7.233e-80	270.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS3_k127_1663490_2	1461693.ATO10_07171	9.833e-39	160.0	COG2335@1|root,COG2931@1|root,COG2335@2|Bacteria,COG2931@2|Bacteria,1PFSZ@1224|Proteobacteria,2U4ER@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MQ	Beta-Ig-H3 fasciclin	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS3_k127_1663490_5	420324.KI912006_gene8681	4.1e-12	78.0	COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2U7AB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MQ	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_1664839_6	1101190.ARWB01000001_gene2816	1.211e-55	205.0	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,2TVD8@28211|Alphaproteobacteria,370FT@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0066	virR	-	-	-	-	-	-	-	-	-	-	-	UPF0066
TLS3_k127_1664839_9	1523503.JPMY01000003_gene4148	2.041e-14	79.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
TLS3_k127_1664839_0	272943.RSP_0658	0.0	1118.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,1FCM2@1060|Rhodobacter	28211|Alphaproteobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
TLS3_k127_1664839_3	216596.RL3057	2.199e-100	353.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1MY46@1224|Proteobacteria,2TVDK@28211|Alphaproteobacteria,4B8VN@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
TLS3_k127_1664839_7	472175.EL18_01040	1.296e-47	189.0	COG2044@1|root,COG2044@2|Bacteria,1RGAZ@1224|Proteobacteria,2UBFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
TLS3_k127_1664839_4	1188256.BASI01000002_gene3043	1.894e-80	274.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,3FDAU@34008|Rhodovulum	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	MA20_22045	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
TLS3_k127_1664839_2	1121271.AUCM01000005_gene596	1.431e-127	414.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS3_k127_1664839_8	272942.RCAP_rcc03189	4.646e-28	115.0	COG1605@1|root,COG1605@2|Bacteria,1NEMH@1224|Proteobacteria,2UGZQ@28211|Alphaproteobacteria,1FC4F@1060|Rhodobacter	28211|Alphaproteobacteria	E	PFAM Chorismate mutase	pchB	-	4.2.99.21	ko:K04782	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R06602	RC01549,RC02148	ko00000,ko00001,ko01000	-	-	-	CM_2
TLS3_k127_1664839_5	1469613.JT55_13650	4.028e-72	250.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2TSEF@28211|Alphaproteobacteria,3FDFR@34008|Rhodovulum	28211|Alphaproteobacteria	S	Uncharacterized protein family, UPF0114	yqhA	-	-	-	-	-	-	-	-	-	-	-	UPF0114
TLS3_k127_1664839_1	1415756.JQMY01000001_gene1419	5.615e-282	872.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,2PC7H@252301|Oceanicola	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS3_k127_1668785_3	1188256.BASI01000002_gene3277	1.931e-52	191.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,3FD4N@34008|Rhodovulum	28211|Alphaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS3_k127_1668785_1	1188256.BASI01000002_gene3276	1.833e-141	469.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,3FCT4@34008|Rhodovulum	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
TLS3_k127_1668785_0	1469613.JT55_09845	3.459e-286	893.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,3FCV7@34008|Rhodovulum	28211|Alphaproteobacteria	C	Thi4 family	etf	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2
TLS3_k127_1668785_2	398580.Dshi_3076	9.322e-70	241.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS3_k127_1668785_4	246200.SPO0311	2.172e-18	97.0	2CJVZ@1|root,2Z84M@2|Bacteria,1MVJ0@1224|Proteobacteria,2TTJI@28211|Alphaproteobacteria,4NBE8@97050|Ruegeria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1686430_2	349102.Rsph17025_2348	3.703e-32	132.0	COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2U9GK@28211|Alphaproteobacteria,1FC4K@1060|Rhodobacter	28211|Alphaproteobacteria	S	SOS response	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
TLS3_k127_1686430_0	1280952.HJA_16540	2.87e-87	303.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	wcaL	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_1686430_1	252305.OB2597_04003	5.362e-77	286.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	GlcNAc,Glyco_tranf_2_3,Glycos_transf_2
TLS3_k127_1691875_1	1245469.S58_32710	1.303e-88	297.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2TSUP@28211|Alphaproteobacteria,3JVJR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	uracil-DNA glycosylase	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS3_k127_1691875_4	443144.GM21_1545	5.758e-13	77.0	COG3637@1|root,COG3637@2|Bacteria,1NGKR@1224|Proteobacteria	1224|Proteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,Opacity,Surface_Ag_2
TLS3_k127_1691875_0	398580.Dshi_0188	6.283e-169	537.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS3_k127_1691875_5	1449350.OCH239_21275	0.0007884	49.0	COG4430@1|root,COG4430@2|Bacteria,1RJGC@1224|Proteobacteria,2U3AS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
TLS3_k127_1691875_3	633131.TR2A62_2958	6.047e-22	102.0	2A57D@1|root,2ZYPI@2|Bacteria,1RDQ9@1224|Proteobacteria,2U7GJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3429
TLS3_k127_1691875_2	1231392.OCGS_1612	3.442e-43	169.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
TLS3_k127_1694825_3	1231392.OCGS_2364	2.179e-07	58.0	28HN0@1|root,2Z7WE@2|Bacteria,1MXRK@1224|Proteobacteria,2TUQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1694825_1	246200.SPO1632	9.526e-114	382.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,4NBJQ@97050|Ruegeria	28211|Alphaproteobacteria	D	Tyrosine recombinase	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_1694825_0	1530186.JQEY01000001_gene1266	1.316e-173	554.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Mg2 and Co2 transporter CorB	corB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_1694825_2	627192.SLG_33930	4.655e-60	217.0	COG0300@1|root,COG0300@2|Bacteria,1QU2C@1224|Proteobacteria,2TWTH@28211|Alphaproteobacteria,2KEPC@204457|Sphingomonadales	204457|Sphingomonadales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_1723146_0	314264.ROS217_07505	6.564e-137	454.0	28JVS@1|root,2Z9KP@2|Bacteria,1R74U@1224|Proteobacteria,2U1XR@28211|Alphaproteobacteria,46RSW@74030|Roseovarius	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1723146_1	118168.MC7420_7338	4.574e-39	161.0	2DTTJ@1|root,32UVW@2|Bacteria,1G8TS@1117|Cyanobacteria,1HCTF@1150|Oscillatoriales	1117|Cyanobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS3_k127_1731821_1	1267535.KB906767_gene3285	8.328e-05	46.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3Y4AH@57723|Acidobacteria,2JJ4R@204432|Acidobacteriia	204432|Acidobacteriia	K	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
TLS3_k127_1731821_0	1185652.USDA257_c39490	1.41e-276	879.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,4BBFS@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	CoA binding domain	MA20_38090	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS3_k127_1744374_1	1123360.thalar_00154	4.782e-73	248.0	COG1802@1|root,COG1802@2|Bacteria,1MVXM@1224|Proteobacteria,2TT9E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator GntR family	mcbR	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_1744374_0	1380380.JIAX01000008_gene2154	1.799e-100	338.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TQJJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_1744374_2	1123060.JONP01000067_gene840	1.194e-41	176.0	COG2931@1|root,COG3866@1|root,COG2931@2|Bacteria,COG3866@2|Bacteria,1MU7T@1224|Proteobacteria,2UCFI@28211|Alphaproteobacteria,2JZKD@204441|Rhodospirillales	28211|Alphaproteobacteria	GQ	Amb_all	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,HemolysinCabind,Pec_lyase_C
TLS3_k127_1744374_3	1449351.RISW2_17110	2.462e-05	56.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1R8UF@1224|Proteobacteria,2UGWH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	QU	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1766109_1	555793.WSK_3573	2.762e-26	123.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1NQG3@1224|Proteobacteria,2UKG4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS3_k127_1766109_0	694430.Natoc_2999	3.663e-32	130.0	COG0463@1|root,arCOG01385@2157|Archaea,2Y7PB@28890|Euryarchaeota,23UIK@183963|Halobacteria	183963|Halobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_1780336_5	1121271.AUCM01000001_gene3328	4.358e-33	132.0	COG1261@1|root,COG1261@2|Bacteria,1PM4C@1224|Proteobacteria,2TRUS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
TLS3_k127_1780336_1	1415756.JQMY01000001_gene405	1.548e-74	263.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TRHN@28211|Alphaproteobacteria,2PCT2@252301|Oceanicola	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
TLS3_k127_1780336_4	388399.SSE37_17173	2.216e-33	134.0	2AGAB@1|root,316FU@2|Bacteria,1RHRI@1224|Proteobacteria,2U96E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Controls the rotational direction of flagella during chemotaxis	fliL2	-	-	-	-	-	-	-	-	-	-	-	FliL
TLS3_k127_1780336_3	411684.HPDFL43_13762	1.308e-47	183.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,2U2YW@28211|Alphaproteobacteria,43R5C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
TLS3_k127_1780336_0	571166.KI421509_gene2748	2.088e-92	327.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TLS3_k127_1780336_2	1294273.roselon_01326	9.973e-51	186.0	COG1684@1|root,COG1684@2|Bacteria,1R6NQ@1224|Proteobacteria,2VGAB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	COG1684 Flagellar biosynthesis pathway, component FliR	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TLS3_k127_1780336_6	1530186.JQEY01000012_gene2539	4.149e-09	59.0	COG1684@1|root,COG1684@2|Bacteria,1R6NQ@1224|Proteobacteria,2VGAB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	COG1684 Flagellar biosynthesis pathway, component FliR	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TLS3_k127_1791124_1	266809.PM03_09710	1.597e-98	331.0	COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,2TSPG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	auxin efflux carrier family protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TLS3_k127_1791124_2	985054.JQEZ01000004_gene898	2.878e-48	178.0	COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,2U9MS@28211|Alphaproteobacteria,4NCA0@97050|Ruegeria	28211|Alphaproteobacteria	S	Hemimethylated DNA-binding protein YccV like	hspQ	-	-	ko:K11940	-	-	-	-	ko00000,ko03036	-	-	-	YccV-like
TLS3_k127_1791124_3	1089551.KE386572_gene3504	5.93e-45	171.0	COG0454@1|root,COG0456@2|Bacteria,1QUS0@1224|Proteobacteria,2TXDS@28211|Alphaproteobacteria,4BSKY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_1791124_0	1417296.U879_00950	1.37e-222	702.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	gamma-glutamyltransferase	ywrD	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS3_k127_1791124_4	439497.RR11_3484	3.323e-41	156.0	2CCMQ@1|root,32RW3@2|Bacteria,1MZHB@1224|Proteobacteria,2UCC9@28211|Alphaproteobacteria,4NC7H@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2794)	MA20_43795	-	-	-	-	-	-	-	-	-	-	-	DUF2794
TLS3_k127_1796219_2	631454.N177_1931	7.922e-90	303.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria,1JPWV@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
TLS3_k127_1796219_3	1121271.AUCM01000005_gene729	4.13e-85	289.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2TSCU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
TLS3_k127_1796219_0	314232.SKA53_00734	6.663e-99	329.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2TUHN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type tungstate transport system, periplasmic component	MA20_34300	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
TLS3_k127_1796219_1	1121271.AUCM01000005_gene727	2.663e-98	334.0	COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,2TU96@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1910, Periplasmic molybdate-binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,PBP_like
TLS3_k127_1799889_2	1415756.JQMY01000005_gene76	8.037e-43	164.0	COG2145@1|root,COG2145@2|Bacteria,1MVES@1224|Proteobacteria,2U13N@28211|Alphaproteobacteria,2PDGJ@252301|Oceanicola	28211|Alphaproteobacteria	H	Hydroxyethylthiazole kinase family	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
TLS3_k127_1799889_3	1123229.AUBC01000001_gene1568	8.339e-39	149.0	2AS6X@1|root,31HJW@2|Bacteria,1RGYJ@1224|Proteobacteria,2U9UH@28211|Alphaproteobacteria,3JUQB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2852)	MA20_04040	-	-	-	-	-	-	-	-	-	-	-	DUF2852
TLS3_k127_1799889_0	331869.BAL199_28285	8.844e-294	921.0	COG1231@1|root,COG1231@2|Bacteria,1MV82@1224|Proteobacteria,2TVEF@28211|Alphaproteobacteria,4BQYW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Flavin containing amine oxidoreductase	iaaM	-	1.13.12.3	ko:K00466	ko00380,map00380	-	R00679	RC00213	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS3_k127_1799889_1	1402135.SUH3_00490	4.46e-79	271.0	COG0388@1|root,COG0388@2|Bacteria,1RA15@1224|Proteobacteria,2U1MJ@28211|Alphaproteobacteria,3ZXI5@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_1802127_3	1038859.AXAU01000005_gene5110	2.545e-16	83.0	2EFIM@1|root,339B1@2|Bacteria,1NMH3@1224|Proteobacteria,2UGEE@28211|Alphaproteobacteria,3K3PE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1802127_4	1123247.AUIJ01000018_gene2684	7.618e-11	68.0	2E4Q0@1|root,32ZIM@2|Bacteria,1N6SU@1224|Proteobacteria,2UFRW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
TLS3_k127_1802127_2	1417296.U879_18335	2.66e-53	203.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_1802127_5	1208323.B30_14169	5.36e-07	60.0	COG5126@1|root,COG5126@2|Bacteria	2|Bacteria	DTZ	Ca2 -binding protein (EF-Hand superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_1,EF-hand_5
TLS3_k127_1802127_1	272943.RSP_3466	4.622e-100	342.0	COG1413@1|root,COG1413@2|Bacteria,1NUN2@1224|Proteobacteria	1224|Proteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS3_k127_1802127_0	272943.RSP_3467	1.209e-116	383.0	COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,2U3GY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2169)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2169
TLS3_k127_1806477_1	1525715.IX54_06115	1.747e-76	261.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,2PU7C@265|Paracoccus	28211|Alphaproteobacteria	L	DHHA1 domain	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS3_k127_1806477_0	266809.PM03_11495	8.027e-160	508.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Fructose-1,6-bisphosphatase	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS3_k127_1814575_2	1300350.DSW25_09335	1.237e-19	91.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TVNW@28211|Alphaproteobacteria,3ZW9K@60136|Sulfitobacter	28211|Alphaproteobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
TLS3_k127_1814575_1	1535287.JP74_07405	1.636e-81	294.0	COG1028@1|root,COG1028@2|Bacteria,1PGYI@1224|Proteobacteria,2VEUE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_1814575_0	1446473.JHWH01000003_gene3259	2.601e-170	539.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,2PUBJ@265|Paracoccus	28211|Alphaproteobacteria	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.9	ko:K05351	ko00040,ko01100,map00040,map01100	M00014	R01896	RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_1818304_1	411684.HPDFL43_18872	6.439e-103	336.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,43IGK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS3_k127_1818304_0	1101192.KB910516_gene1787	3.64e-121	398.0	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2TU43@28211|Alphaproteobacteria,1JSYY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF808)	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
TLS3_k127_1818304_2	467661.RKLH11_2762	1.961e-68	238.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,3ZHAB@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	S	EVE domain	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
TLS3_k127_1818304_3	1336208.JADY01000031_gene3977	6.857e-07	53.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
TLS3_k127_1827064_3	1530186.JQEY01000001_gene1387	4.346e-27	115.0	COG3718@1|root,COG3718@2|Bacteria,1MWGD@1224|Proteobacteria,2TUJZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	enzyme involved in inositol metabolism	iolB1	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS3_k127_1827064_2	391616.OA238_c17180	3.254e-93	306.0	COG3718@1|root,COG3718@2|Bacteria,1MWGD@1224|Proteobacteria,2TUJZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	enzyme involved in inositol metabolism	iolB1	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS3_k127_1827064_4	460265.Mnod_2521	5.707e-24	102.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,1JTM0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	TIGRFAM methylmalonate-semialdehyde dehydrogenase	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_1827064_1	575540.Isop_3609	1.274e-98	332.0	COG1087@1|root,COG1087@2|Bacteria,2IY22@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS3_k127_1827064_0	272943.RSP_1113	2.318e-108	366.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1FCQS@1060|Rhodobacter	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_1828187_4	349102.Rsph17025_0863	1.929e-151	492.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,1FB56@1060|Rhodobacter	28211|Alphaproteobacteria	C	PFAM FAD dependent oxidoreductase	ordL	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
TLS3_k127_1828187_1	1469613.JT55_08640	2.69e-175	559.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2TQJY@28211|Alphaproteobacteria,3FCHB@34008|Rhodovulum	28211|Alphaproteobacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
TLS3_k127_1828187_8	1121033.AUCF01000014_gene1215	2.736e-116	384.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TTVF@28211|Alphaproteobacteria,2JV6P@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008874,GO:0008875,GO:0016491,GO:0016614,GO:0016616,GO:0036094,GO:0042802,GO:0042803,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
TLS3_k127_1828187_9	375451.RD1_3690	7.652e-112	368.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,2P0XE@2433|Roseobacter	28211|Alphaproteobacteria	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
TLS3_k127_1828187_12	326427.Cagg_1551	5.659e-43	177.0	COG0726@1|root,COG0726@2|Bacteria,2G76U@200795|Chloroflexi,377KB@32061|Chloroflexia	32061|Chloroflexia	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	LysM,Polysacc_deac_1
TLS3_k127_1828187_13	1306174.JODP01000010_gene7023	1.253e-39	166.0	COG1216@1|root,COG1216@2|Bacteria,2I2M3@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_1828187_3	1336235.JAEG01000010_gene3202	8.157e-156	500.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,4B9PT@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS3_k127_1828187_7	1320556.AVBP01000013_gene1556	8.478e-124	409.0	COG1940@1|root,COG2345@1|root,COG1940@2|Bacteria,COG2345@2|Bacteria,1MVGQ@1224|Proteobacteria,2TRFX@28211|Alphaproteobacteria,43I6N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
TLS3_k127_1828187_2	716928.AJQT01000035_gene800	2.624e-167	533.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TT8F@28211|Alphaproteobacteria,4B7NQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, periplasmic component	frcB	-	-	ko:K10552	ko02010,map02010	M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.7	-	-	Peripla_BP_4
TLS3_k127_1828187_0	1156935.QWE_19983	3.189e-178	564.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TRJJ@28211|Alphaproteobacteria,4B7A2@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	frcC	-	-	ko:K10553	ko02010,map02010	M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.7	-	-	BPD_transp_2
TLS3_k127_1828187_5	935557.ATYB01000014_gene1463	1.679e-137	449.0	COG1129@1|root,COG1129@2|Bacteria,1MVNR@1224|Proteobacteria,2TTN8@28211|Alphaproteobacteria,4B72S@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter	frcA	-	-	ko:K10554	ko02010,map02010	M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.7	-	-	ABC_tran
TLS3_k127_1828187_10	1144310.PMI07_000353	1.78e-60	227.0	COG0572@1|root,COG0572@2|Bacteria,1QV2B@1224|Proteobacteria,2TW8T@28211|Alphaproteobacteria,4BNS5@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Phosphoribulokinase / Uridine kinase family	frcK	-	-	-	-	-	-	-	-	-	-	-	ArgK,PRK
TLS3_k127_1828187_6	1123360.thalar_01529	2.642e-129	423.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TQQ5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS3_k127_1828187_11	391613.RTM1035_14322	3.911e-57	202.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,46QQ3@74030|Roseovarius	28211|Alphaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS3_k127_1828187_14	1121033.AUCF01000018_gene5788	3.242e-08	60.0	2DQZR@1|root,339JT@2|Bacteria,1NI88@1224|Proteobacteria,2VGGF@28211|Alphaproteobacteria,2JYCA@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
TLS3_k127_1874052_4	272943.RSP_0344	1.651e-101	337.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,1FB4B@1060|Rhodobacter	28211|Alphaproteobacteria	S	PFAM ABC transporter	rbsA4	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_1874052_3	391613.RTM1035_17890	4.936e-143	461.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2TUGD@28211|Alphaproteobacteria,46NID@74030|Roseovarius	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_1874052_2	991905.SL003B_2460	3.052e-152	485.0	COG1079@1|root,COG1079@2|Bacteria,1NAYV@1224|Proteobacteria,2TTM0@28211|Alphaproteobacteria,4BPGU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_1874052_0	991905.SL003B_2461	2.138e-212	669.0	COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2U0IN@28211|Alphaproteobacteria,4BPXX@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Amidohydrolase family	codA	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_3
TLS3_k127_1874052_1	1294273.roselon_02264	1.304e-180	576.0	COG1804@1|root,COG1804@2|Bacteria,1R43P@1224|Proteobacteria,2U1WN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	5.4.1.3	ko:K14470	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09283	RC02480	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
TLS3_k127_1874052_5	1187851.A33M_1370	1.459e-60	214.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2TV0U@28211|Alphaproteobacteria,3FE75@34008|Rhodovulum	28211|Alphaproteobacteria	S	N-terminal half of MaoC dehydratase	-	-	4.2.1.153	ko:K09709	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09282	RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
TLS3_k127_1875780_1	1188256.BASI01000003_gene2499	6.264e-118	387.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2TS0D@28211|Alphaproteobacteria,3FCRR@34008|Rhodovulum	28211|Alphaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS3_k127_1875780_0	1469613.JT55_11545	1.278e-158	514.0	COG0477@1|root,COG0477@2|Bacteria,1QTUM@1224|Proteobacteria,2TVX9@28211|Alphaproteobacteria,3FEMV@34008|Rhodovulum	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_1895808_1	1449350.OCH239_09340	2.946e-26	109.0	COG0697@1|root,COG0697@2|Bacteria,1RKE2@1224|Proteobacteria,2UDNZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_1895808_0	398580.Dshi_2679	2.593e-320	1000.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_1917867_3	985054.JQEZ01000003_gene1270	1.373e-63	230.0	COG3568@1|root,COG3568@2|Bacteria,1QV2C@1224|Proteobacteria,2U065@28211|Alphaproteobacteria,4N9SU@97050|Ruegeria	28211|Alphaproteobacteria	S	Endonuclease exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_1917867_1	1294273.roselon_01233	8.854e-107	348.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS3_k127_1917867_2	1333998.M2A_2478	1.754e-64	227.0	COG3751@1|root,COG3751@2|Bacteria,1R4BC@1224|Proteobacteria,2U2Q5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
TLS3_k127_1917867_0	1123229.AUBC01000018_gene3652	1.183e-232	725.0	COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,2TSG4@28211|Alphaproteobacteria,3JUTQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the xylose isomerase family	xylA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_1917867_4	1122963.AUHB01000001_gene299	1.917e-39	151.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TR7P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylulose kinase	xylB	GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_1919343_0	1123237.Salmuc_03743	3.211e-139	456.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS3_k127_1950094_5	252305.OB2597_13198	4.2e-37	141.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2U94X@28211|Alphaproteobacteria,2PE2Y@252301|Oceanicola	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS3_k127_1950094_3	252305.OB2597_13188	1.882e-57	209.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,2PDX1@252301|Oceanicola	28211|Alphaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS3_k127_1950094_0	631454.N177_0859	5.636e-98	334.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,1JN21@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	tRNA (Guanine-1)-methyltransferase	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS3_k127_1950094_4	666509.RCA23_c29040	1.578e-51	199.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS3_k127_1950094_6	1415756.JQMY01000001_gene1241	1.294e-32	136.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria,2PEMT@252301|Oceanicola	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL31 family	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS3_k127_1950094_1	1122218.KB893663_gene1714	3.859e-94	318.0	COG1192@1|root,COG1192@2|Bacteria,1MVKR@1224|Proteobacteria,2TRZY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	COG1192 ATPases involved in chromosome partitioning	mipZ	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MipZ
TLS3_k127_1950094_2	1317124.DW2_03349	1.296e-63	221.0	COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,2TTWH@28211|Alphaproteobacteria,2XNK9@285107|Thioclava	28211|Alphaproteobacteria	S	KR domain	MA20_24385	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_1956723_0	1469613.JT55_08555	2.461e-293	920.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,3FDMM@34008|Rhodovulum	28211|Alphaproteobacteria	E	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
TLS3_k127_1956723_4	1469613.JT55_08550	3.287e-14	81.0	COG4583@1|root,COG4583@2|Bacteria,1RC66@1224|Proteobacteria,2U5RU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Sarcosine oxidase, gamma subunit	soxGe	-	1.5.3.1	ko:K00305	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
TLS3_k127_1956723_1	1211115.ALIQ01000199_gene526	1.439e-160	546.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TRT9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Oxidative deamination of D-amino acids	dadA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0008718,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019478,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055114,GO:0055130,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO
TLS3_k127_1956723_2	1122614.JHZF01000011_gene1891	3.482e-114	392.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,2TRDT@28211|Alphaproteobacteria,2PE7R@252301|Oceanicola	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_1956723_3	1122614.JHZF01000011_gene1884	8.238e-41	165.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_1956723_5	445972.ANACOL_01173	7.6e-12	77.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,3WJSS@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS3_k127_198177_1	1469613.JT55_15320	3.848e-74	254.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,3FCZR@34008|Rhodovulum	28211|Alphaproteobacteria	H	ThiF family	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS3_k127_198177_2	1121271.AUCM01000004_gene1240	2.884e-51	188.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	MA20_17975	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TLS3_k127_198177_0	349102.Rsph17025_0575	1.806e-126	409.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria,1FAZB@1060|Rhodobacter	28211|Alphaproteobacteria	S	YmdB-like protein	MA20_17970	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS3_k127_198177_3	89187.ISM_09611	2.071e-21	109.0	COG0697@1|root,COG0697@2|Bacteria,1PDMU@1224|Proteobacteria,2U0T9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_1992039_3	314265.R2601_08561	9.253e-41	158.0	COG1652@1|root,COG1652@2|Bacteria,1MWMR@1224|Proteobacteria,2U7UH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	protein containing LysM domain	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS3_k127_1992039_0	1469613.JT55_04510	1.809e-266	833.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,3FCRT@34008|Rhodovulum	28211|Alphaproteobacteria	O	ABC transporter transmembrane region	atm1	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_1992039_1	314271.RB2654_16656	3.001e-182	581.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS3_k127_1992039_2	1123054.KB907705_gene2419	2.474e-130	426.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X2I3@135613|Chromatiales	135613|Chromatiales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS3_k127_1996641_3	501479.ACNW01000046_gene163	3.408e-31	136.0	COG5456@1|root,COG5456@2|Bacteria,1RHKI@1224|Proteobacteria,2U9GB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM FixH family protein	fixH	-	-	-	-	-	-	-	-	-	-	-	FixH
TLS3_k127_1996641_0	1469613.JT55_14845	9.343e-211	666.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2TRYB@28211|Alphaproteobacteria,3FCGY@34008|Rhodovulum	28211|Alphaproteobacteria	C	IG-like fold at C-terminal of FixG, putative oxidoreductase	ccoG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
TLS3_k127_1996641_4	1246995.AFR_24690	3.375e-28	117.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4DF02@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_1996641_5	266264.Rmet_2501	1.163e-19	94.0	COG0625@1|root,COG3832@1|root,COG0625@2|Bacteria,COG3832@2|Bacteria,1RI7Y@1224|Proteobacteria,2VW09@28216|Betaproteobacteria,1K8QR@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_1996641_2	1385517.N800_03190	1.76e-84	295.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,1S31J@1236|Gammaproteobacteria,1X6CJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
TLS3_k127_1996641_1	1123247.AUIJ01000012_gene843	9.02e-90	304.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TUTH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
TLS3_k127_200838_11	1317118.ATO8_11244	8.356e-32	127.0	COG1734@1|root,COG1734@2|Bacteria,1MZIB@1224|Proteobacteria,2UCQA@28211|Alphaproteobacteria,4KMX6@93682|Roseivivax	28211|Alphaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
TLS3_k127_200838_3	1121028.ARQE01000002_gene2191	6.269e-119	391.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2TR7R@28211|Alphaproteobacteria,2PJDJ@255475|Aurantimonadaceae	28211|Alphaproteobacteria	EH	Amino-transferase class IV	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
TLS3_k127_200838_2	526222.Desal_1396	1.506e-123	410.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2MAA8@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Mandelate racemase muconate lactonizing	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
TLS3_k127_200838_0	1415756.JQMY01000001_gene3014	3.58e-160	510.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,2TS0Y@28211|Alphaproteobacteria,2PD67@252301|Oceanicola	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
TLS3_k127_200838_10	1030157.AFMP01000011_gene3785	1.31e-33	141.0	COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,2UG08@28211|Alphaproteobacteria,2KD6N@204457|Sphingomonadales	204457|Sphingomonadales	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_9
TLS3_k127_200838_12	666509.RCA23_c25880	4.345e-08	61.0	2CXG1@1|root,32T1W@2|Bacteria,1MZFE@1224|Proteobacteria,2UCTB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_200838_1	1123501.KB902282_gene2526	2.267e-147	474.0	COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2TRDE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase	yqjG	GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
TLS3_k127_200838_8	1123060.JONP01000012_gene2829	6.464e-58	205.0	COG1917@1|root,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,2U990@28211|Alphaproteobacteria,2JT27@204441|Rhodospirillales	204441|Rhodospirillales	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_200838_9	1469613.JT55_15560	2.464e-43	165.0	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,3FDCY@34008|Rhodovulum	28211|Alphaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
TLS3_k127_200838_6	1121479.AUBS01000007_gene2200	9.022e-78	271.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980,ko:K22073	-	-	-	-	ko00000,ko01000,ko03016,ko03029	-	-	-	GCV_T,GCV_T_C
TLS3_k127_200838_4	1417296.U879_09810	6.571e-113	370.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS3_k127_200838_5	1089551.KE386572_gene3060	1.465e-89	303.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2U1MH@28211|Alphaproteobacteria,4BSEY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_200838_7	1229205.BUPH_02927	1.19e-71	251.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2VN1A@28216|Betaproteobacteria,1K38D@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
TLS3_k127_2008711_4	272943.RSP_1066	1.398e-75	261.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,1FAPD@1060|Rhodobacter	28211|Alphaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
TLS3_k127_2008711_3	290400.Jann_0635	2.024e-80	286.0	COG0110@1|root,COG0110@2|Bacteria,1MUCJ@1224|Proteobacteria,2U3UD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	acetyltransferase, isoleucine patch superfamily	vatD	-	2.3.1.28	ko:K00638,ko:K18234	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Hexapep
TLS3_k127_2008711_2	1188256.BASI01000001_gene359	1.652e-81	292.0	COG3217@1|root,COG3217@2|Bacteria,1MVSP@1224|Proteobacteria,2U1ST@28211|Alphaproteobacteria,3FDUD@34008|Rhodovulum	28211|Alphaproteobacteria	S	MOSC domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
TLS3_k127_2008711_0	1123247.AUIJ01000004_gene1036	3.096e-245	771.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
TLS3_k127_2008711_1	1337093.MBE-LCI_1271	3.198e-97	338.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2P9PG@245186|Loktanella	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
TLS3_k127_2009441_0	1449351.RISW2_15815	4.509e-157	504.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,4KMFU@93682|Roseivivax	28211|Alphaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS3_k127_2009441_2	272943.RSP_6037	2.574e-10	64.0	COG5457@1|root,COG5457@2|Bacteria,1NGSY@1224|Proteobacteria,2UJV7@28211|Alphaproteobacteria,1FC7E@1060|Rhodobacter	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1127
TLS3_k127_2009441_1	1121271.AUCM01000001_gene3341	1.265e-14	78.0	COG3951@1|root,COG3951@2|Bacteria,1N8ET@1224|Proteobacteria,2UF4I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Flagellar protein FlgJ	flgJ	-	-	-	-	-	-	-	-	-	-	-	Rod-binding
TLS3_k127_2020490_3	1448389.BAVQ01000002_gene2942	5.65e-57	207.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS3_k127_2020490_1	1472418.BBJC01000006_gene2441	1.399e-128	420.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2TSP5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	MA20_40340	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS3_k127_2020490_2	1472418.BBJC01000006_gene2442	5.438e-109	368.0	COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2U0Z1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	cytosine deaminase	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_3
TLS3_k127_2020490_0	1472418.BBJC01000006_gene2443	5.127e-186	610.0	COG0277@1|root,COG0277@2|Bacteria,1MUKV@1224|Proteobacteria,2TVCQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
TLS3_k127_2020490_4	1410620.SHLA_2c000210	1.014e-43	162.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2TTW8@28211|Alphaproteobacteria,4BD0K@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Nitrate sulfonate bicarbonate	MA20_40330	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS3_k127_2046839_3	1217708.F887_02785	2.235e-07	59.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,3NIPA@468|Moraxellaceae	1236|Gammaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
TLS3_k127_2046839_2	371731.Rsw2DRAFT_1291	5.311e-15	84.0	2EIVR@1|root,31A7J@2|Bacteria,1Q52J@1224|Proteobacteria,2VBGN@28211|Alphaproteobacteria,1FD0J@1060|Rhodobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2046839_0	1121271.AUCM01000001_gene3643	1.633e-94	313.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
TLS3_k127_2046839_1	419610.Mext_3063	3.921e-92	313.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,1JTCH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS_3,PAS_4,PAS_7
TLS3_k127_2083986_0	1144312.PMI09_01636	4.703e-148	476.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4B96J@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS3_k127_2083986_1	1146883.BLASA_3143	1.602e-108	373.0	COG1028@1|root,COG1028@2|Bacteria,2I72Q@201174|Actinobacteria,4EU4J@85013|Frankiales	201174|Actinobacteria	IQ	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_2083986_2	1337093.MBE-LCI_2546	1.76e-39	151.0	COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,2TUJ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldo keto reductase	-	-	1.1.1.122	ko:K00064	ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120	M00114	R07675,R08926	RC00066,RC00161	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldo_ket_red
TLS3_k127_2101008_5	991905.SL003B_3566	1.52e-109	378.0	COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria,4BPSQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	proV	GO:0000166,GO:0003674,GO:0004888,GO:0005034,GO:0005215,GO:0005275,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0023052,GO:0030554,GO:0031224,GO:0031460,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0038023,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060089,GO:0065007,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
TLS3_k127_2101008_4	1415756.JQMY01000001_gene1827	7.637e-121	393.0	COG4176@1|root,COG4176@2|Bacteria,1QTTE@1224|Proteobacteria,2TS3U@28211|Alphaproteobacteria,2PDTH@252301|Oceanicola	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	choW	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS3_k127_2101008_3	1288298.rosmuc_02805	3.062e-126	412.0	COG2113@1|root,COG2113@2|Bacteria,1MVIG@1224|Proteobacteria,2TRV8@28211|Alphaproteobacteria,46Q04@74030|Roseovarius	28211|Alphaproteobacteria	E	COG2113 ABC-type proline glycine betaine transport systems, periplasmic components	proX	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS3_k127_2101008_7	991905.SL003B_3569	7.544e-52	190.0	COG1309@1|root,COG1309@2|Bacteria,1R22U@1224|Proteobacteria,2TZ9H@28211|Alphaproteobacteria,4BR3C@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	ko:K02167	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_6,TetR_N
TLS3_k127_2101008_1	195105.CN97_00970	3.801e-216	682.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	betB	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_2101008_0	935261.JAGL01000011_gene2058	2.69e-263	847.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,43INN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_2101008_9	1500257.JQNM01000004_gene453	2.29e-20	103.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BEA9@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase2,HemolysinCabind
TLS3_k127_2101008_6	864069.MicloDRAFT_00013410	4.513e-85	294.0	28Z9U@1|root,2ZM1P@2|Bacteria,1RBFF@1224|Proteobacteria,2U5YY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2101008_8	1502851.FG93_03274	4.171e-21	107.0	COG2931@1|root,COG2931@2|Bacteria,1RCXD@1224|Proteobacteria,2U863@28211|Alphaproteobacteria,3K2K4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,HemolysinCabind
TLS3_k127_2101008_2	1317124.DW2_05400	2.049e-132	428.0	COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2U0FZ@28211|Alphaproteobacteria,2XPE2@285107|Thioclava	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
TLS3_k127_2107144_1	1245471.PCA10_29530	6.965e-76	263.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1YJRX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,Cytochrom_C
TLS3_k127_2107144_0	1305735.JAFT01000004_gene170	0.0	1140.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,2PDDI@252301|Oceanicola	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	ctaD	-	1.9.3.1	ko:K02274,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS3_k127_2134786_3	1367847.JCM7686_0901	7.469e-74	250.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,2PVBD@265|Paracoccus	28211|Alphaproteobacteria	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS3_k127_2134786_2	388051.AUFE01000016_gene5836	9.905e-85	300.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VNGN@28216|Betaproteobacteria,1K0ZX@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_2134786_6	1415756.JQMY01000001_gene1236	2.776e-51	192.0	COG1266@1|root,COG1266@2|Bacteria,1RFHC@1224|Proteobacteria,2U7KR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Abortive infection protein	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS3_k127_2134786_1	1156935.QWE_24073	1.667e-123	409.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,4B8BK@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS3_k127_2134786_0	1530186.JQEY01000001_gene1260	1.03e-129	425.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TUBY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	component I	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
TLS3_k127_2134786_5	391619.PGA1_c24540	2.577e-57	206.0	COG0115@1|root,COG0115@2|Bacteria,1RF9H@1224|Proteobacteria,2U6QR@28211|Alphaproteobacteria,34FCR@302485|Phaeobacter	28211|Alphaproteobacteria	E	Amino-transferase class IV	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
TLS3_k127_2134786_4	1305735.JAFT01000005_gene788	8.453e-74	264.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,2PCB0@252301|Oceanicola	28211|Alphaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS3_k127_2138669_7	1122247.C731_0241	2.294e-36	139.0	COG4577@1|root,COG4577@2|Bacteria,2IM0X@201174|Actinobacteria,239YP@1762|Mycobacteriaceae	201174|Actinobacteria	CQ	Carbon dioxide concentrating mechanism carboxysome shell protein	pduA	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
TLS3_k127_2138669_8	1194972.MVAC_12913	2.794e-24	111.0	COG4576@1|root,COG4576@2|Bacteria,2IQV8@201174|Actinobacteria,23ARZ@1762|Mycobacteriaceae	201174|Actinobacteria	CQ	Ethanolamine utilization protein EutN	-	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
TLS3_k127_2138669_9	1150599.MPHLEI_03558	0.0001166	53.0	2ESM9@1|root,33K5U@2|Bacteria,2IIGK@201174|Actinobacteria,238YK@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2138669_5	1122247.C731_0244	2.575e-73	255.0	COG4577@1|root,COG4577@2|Bacteria,2HX34@201174|Actinobacteria,237JQ@1762|Mycobacteriaceae	201174|Actinobacteria	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
TLS3_k127_2138669_2	258533.BN977_03328	5.443e-142	467.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,235F6@1762|Mycobacteriaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.10,1.2.1.81	ko:K00132,ko:K15515	ko00620,ko00650,ko01100,ko01120,map00620,map00650,map01100,map01120	-	R00228,R01172	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
TLS3_k127_2138669_1	266835.14026356	9.032e-204	641.0	COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,2TU7P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS3_k127_2138669_6	1038858.AXBA01000003_gene4248	9.328e-67	239.0	COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,2U0QH@28211|Alphaproteobacteria,3EYZ7@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	DeoR C terminal sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
TLS3_k127_2138669_3	765698.Mesci_1077	4.812e-107	352.0	COG1028@1|root,COG1028@2|Bacteria,1R3R1@1224|Proteobacteria,2U0MM@28211|Alphaproteobacteria,43NPP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_2138669_4	1449351.RISW2_15380	1.575e-91	316.0	COG2267@1|root,COG2267@2|Bacteria,1NYNM@1224|Proteobacteria,2TWBS@28211|Alphaproteobacteria,4KK4S@93682|Roseivivax	28211|Alphaproteobacteria	I	Thioesterase domain	ybfF	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_2138669_0	1121106.JQKB01000032_gene4434	7.601e-319	1002.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_2146827_0	1337093.MBE-LCI_0743	1.46e-176	559.0	COG0849@1|root,COG1589@1|root,COG0849@2|Bacteria,COG1589@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,2P870@245186|Loktanella	28211|Alphaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS3_k127_2146827_1	1317124.DW2_13165	1.434e-174	559.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,2XM2G@285107|Thioclava	28211|Alphaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS3_k127_2155167_0	794846.AJQU01000042_gene5336	7.851e-141	456.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4B81P@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS3_k127_2160660_3	1449351.RISW2_07920	2.627e-66	237.0	2BWZZ@1|root,2Z7V7@2|Bacteria,1PFGK@1224|Proteobacteria,2TUWA@28211|Alphaproteobacteria,4KM1B@93682|Roseivivax	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2927)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2927
TLS3_k127_2160660_5	398580.Dshi_1882	6.636e-52	189.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_2160660_4	195105.CN97_04440	4.269e-66	229.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
TLS3_k127_2160660_6	314256.OG2516_07487	5.08e-06	54.0	2AJ0U@1|root,319IW@2|Bacteria,1RGWP@1224|Proteobacteria,2U9I9@28211|Alphaproteobacteria,2PEH0@252301|Oceanicola	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2160660_2	622637.KE124774_gene3704	2.658e-76	278.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,36Y9I@31993|Methylocystaceae	28211|Alphaproteobacteria	K	Sir2 family	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS3_k127_2160660_1	195105.CN97_02435	1.678e-76	265.0	2DB9X@1|root,2Z7ZS@2|Bacteria,1N6CK@1224|Proteobacteria,2U2ME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3445)	-	-	1.14.13.238	ko:K22342	-	-	-	-	ko00000,ko01000	-	-	-	DUF3445
TLS3_k127_2160660_0	1469613.JT55_01815	3.612e-240	763.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria,3FCNF@34008|Rhodovulum	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS3_k127_2191011_2	1569209.BBPH01000089_gene2089	2.432e-125	409.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2PXF5@265|Paracoccus	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_2191011_5	1294273.roselon_01250	2.063e-66	229.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS3_k127_2191011_7	580332.Slit_0391	6.024e-51	189.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2VR0S@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase (SDR)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_2191011_1	1469613.JT55_07260	1.756e-128	427.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,3FCT3@34008|Rhodovulum	28211|Alphaproteobacteria	EM	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS3_k127_2191011_0	195105.CN97_10880	4.884e-159	523.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
TLS3_k127_2191011_8	1231392.OCGS_0619	2.606e-34	149.0	COG3861@1|root,COG3861@2|Bacteria,1QXYQ@1224|Proteobacteria,2U3F6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS3_k127_2191011_4	1415756.JQMY01000001_gene1065	2.697e-105	349.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2TU7N@28211|Alphaproteobacteria,2PDQI@252301|Oceanicola	28211|Alphaproteobacteria	EG	EamA-like transporter family	sam	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_2191011_6	371731.Rsw2DRAFT_0858	8.174e-62	227.0	COG0665@1|root,COG0665@2|Bacteria,1MUUJ@1224|Proteobacteria,2TR9J@28211|Alphaproteobacteria,1FBJS@1060|Rhodobacter	28211|Alphaproteobacteria	E	PFAM FAD dependent oxidoreductase	goxB	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
TLS3_k127_2191011_3	1449351.RISW2_20320	1.2e-117	385.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,4KK7R@93682|Roseivivax	28211|Alphaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
TLS3_k127_2210019_0	1525715.IX54_08615	1.074e-307	966.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,2PV9T@265|Paracoccus	28211|Alphaproteobacteria	E	2Fe-2S iron-sulfur cluster binding domain	soxA	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
TLS3_k127_2210019_6	246200.SPO2344	2.608e-36	144.0	COG4583@1|root,COG4583@2|Bacteria,1N27A@1224|Proteobacteria,2U77J@28211|Alphaproteobacteria,4NBQV@97050|Ruegeria	28211|Alphaproteobacteria	E	Sarcosine oxidase, gamma subunit	soxG	-	1.5.3.1	ko:K00305	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
TLS3_k127_2210019_4	1089552.KI911559_gene1916	5.8e-77	285.0	COG4782@1|root,COG4782@2|Bacteria,1MXVC@1224|Proteobacteria,2V79W@28211|Alphaproteobacteria,2JSIV@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
TLS3_k127_2210019_3	1122135.KB893171_gene2128	1.078e-78	270.0	COG0834@1|root,COG0834@2|Bacteria,1NT2J@1224|Proteobacteria,2TU1I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
TLS3_k127_2210019_5	399741.Spro_2398	2.215e-60	217.0	COG4215@1|root,COG4215@2|Bacteria,1R7WB@1224|Proteobacteria,1S0P9@1236|Gammaproteobacteria,400K5@613|Serratia	1236|Gammaproteobacteria	E	ABC transporter	hisQ_2	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS3_k127_2210019_2	999611.KI421504_gene2552	3.174e-80	276.0	COG4160@1|root,COG4160@2|Bacteria,1QV6B@1224|Proteobacteria,2U1EA@28211|Alphaproteobacteria,282F0@191028|Leisingera	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
TLS3_k127_2210019_1	1185766.DL1_04850	3.255e-98	329.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2TUNR@28211|Alphaproteobacteria,2XKQ3@285107|Thioclava	28211|Alphaproteobacteria	J	SAM-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS3_k127_2210923_0	570952.ATVH01000014_gene1833	2.216e-147	473.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2JQ4W@204441|Rhodospirillales	204441|Rhodospirillales	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS3_k127_2210923_2	29306.JOBE01000033_gene5672	2.767e-51	203.0	COG0500@1|root,COG3153@1|root,COG0500@2|Bacteria,COG3153@2|Bacteria,2IKX0@201174|Actinobacteria	201174|Actinobacteria	Q	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9,Methyltransf_11,Methyltransf_25
TLS3_k127_2210923_1	1417296.U879_10805	5.379e-58	220.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2U08T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Phytoene squalene synthetase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291,ko:K18163	ko00906,ko01062,ko01100,ko01110,ko04714,map00906,map01062,map01100,map01110,map04714	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	SQS_PSY
TLS3_k127_2210923_3	314271.RB2654_01770	1.273e-17	83.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_2226171_1	1469613.JT55_04530	3.716e-110	373.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,3FDWK@34008|Rhodovulum	28211|Alphaproteobacteria	S	PQQ-like domain	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
TLS3_k127_2226171_0	1449351.RISW2_20870	2.195e-212	670.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,4KK4M@93682|Roseivivax	28211|Alphaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
TLS3_k127_2226171_3	1123501.KB902310_gene173	8.007e-74	252.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Intracellular protease	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS3_k127_2226171_6	326424.FRAAL1691	0.0004205	51.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria	201174|Actinobacteria	K	epoxide hydrolase	-	-	3.3.2.9	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
TLS3_k127_2226171_5	222534.KB893726_gene348	2.177e-05	48.0	COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria	201174|Actinobacteria	K	epoxide hydrolase	-	-	-	ko:K21159	ko01059,map01059	-	-	-	ko00000,ko00001	-	-	-	EHN
TLS3_k127_2226171_2	1123501.KB902279_gene535	2.546e-95	320.0	COG0583@1|root,COG0583@2|Bacteria,1PR6U@1224|Proteobacteria,2TUC6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	yofA	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_2226171_4	1123247.AUIJ01000010_gene103	2.499e-07	53.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2U74E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
TLS3_k127_2229145_3	1082931.KKY_2433	2.912e-52	189.0	2940Y@1|root,2ZRFS@2|Bacteria,1RF8A@1224|Proteobacteria,2UHTS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	L-alanine exporter	alaE	-	-	-	-	-	-	-	-	-	-	-	AlaE
TLS3_k127_2229145_0	1469613.JT55_15900	1.269e-150	482.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,3FCH5@34008|Rhodovulum	28211|Alphaproteobacteria	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS3_k127_2229145_4	272943.RSP_1677	6.764e-45	179.0	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UCBQ@28211|Alphaproteobacteria,1FBZE@1060|Rhodobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1491)	MA20_15690	-	-	-	-	-	-	-	-	-	-	-	DUF1491
TLS3_k127_2229145_2	349521.HCH_01122	3.521e-59	219.0	COG2885@1|root,COG2885@2|Bacteria,1R4CA@1224|Proteobacteria,1S37I@1236|Gammaproteobacteria,1XP52@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4892,OmpA
TLS3_k127_2229145_1	1188256.BASI01000001_gene519	2.42e-61	216.0	COG1381@1|root,COG1381@2|Bacteria,1MVEJ@1224|Proteobacteria,2TTYW@28211|Alphaproteobacteria,3FD5H@34008|Rhodovulum	28211|Alphaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS3_k127_2237328_1	1469613.JT55_01195	3.734e-85	310.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,3FCWT@34008|Rhodovulum	28211|Alphaproteobacteria	I	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	gpsA	GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS3_k127_2237328_0	1121271.AUCM01000006_gene161	1.778e-139	460.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
TLS3_k127_2237328_2	1430440.MGMSRv2_0906	1.902e-26	126.0	COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2U1Y2@28211|Alphaproteobacteria,2JS8C@204441|Rhodospirillales	204441|Rhodospirillales	H	COG1587 Uroporphyrinogen-III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Mitofilin
TLS3_k127_2237328_3	1472418.BBJC01000001_gene758	4.311e-20	104.0	COG4223@1|root,COG4223@2|Bacteria,1RHEC@1224|Proteobacteria,2UAF8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	Mitofilin
TLS3_k127_2261531_3	52598.EE36_15297	6.179e-42	161.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,3ZXS8@60136|Sulfitobacter	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS3_k127_2261531_4	388739.RSK20926_18952	4.248e-39	148.0	COG0261@1|root,COG3743@1|root,COG0261@2|Bacteria,COG3743@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria,2P24S@2433|Roseobacter	28211|Alphaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L21p
TLS3_k127_2261531_1	439496.RBY4I_3401	4.534e-148	499.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	kefA	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	DUF3772,MS_channel
TLS3_k127_2261531_0	376733.IT41_02575	2.294e-171	543.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,2PV6Y@265|Paracoccus	28211|Alphaproteobacteria	E	forms a complex with serine acetyltransferase CysE	cysB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_2261531_2	1188256.BASI01000002_gene3537	4.026e-57	211.0	COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,2TTKQ@28211|Alphaproteobacteria,3FDG2@34008|Rhodovulum	28211|Alphaproteobacteria	L	NUDIX domain	trgB	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	GGACT,NUDIX
TLS3_k127_2263693_1	1122218.KB893653_gene1425	2.074e-126	427.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JRHV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_2263693_5	1188256.BASI01000001_gene983	3.378e-10	70.0	2ESC7@1|root,33JX0@2|Bacteria,1NHWS@1224|Proteobacteria,2UMQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2263693_4	349102.Rsph17025_2804	2.897e-78	272.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2U5GF@28211|Alphaproteobacteria,1FCKM@1060|Rhodobacter	28211|Alphaproteobacteria	H	Glutathione S-transferase, N-terminal domain	yibF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
TLS3_k127_2263693_2	314256.OG2516_13976	1.803e-112	365.0	COG4725@1|root,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,2PCD8@252301|Oceanicola	28211|Alphaproteobacteria	L	Belongs to the MT-A70-like family	-	-	-	-	-	-	-	-	-	-	-	-	MT-A70
TLS3_k127_2263693_3	1123360.thalar_00079	1.964e-89	302.0	28J7N@1|root,2Z931@2|Bacteria,1MU88@1224|Proteobacteria,2U33G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Restriction endonuclease BglII	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc-BglII
TLS3_k127_2263693_0	1122218.KB893654_gene1873	2.572e-233	728.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,1JRXF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS3_k127_2270122_1	391616.OA238_c07410	4.938e-06	54.0	2C40D@1|root,2Z7MY@2|Bacteria,1MUQA@1224|Proteobacteria,2TTM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2270122_0	1188256.BASI01000005_gene1758	2.027e-90	315.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,3FCI5@34008|Rhodovulum	28211|Alphaproteobacteria	M	Penicillin-binding protein 5, C-terminal domain	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
TLS3_k127_2275967_3	1380391.JIAS01000018_gene1015	1.724e-75	256.0	COG2049@1|root,COG2049@2|Bacteria,1MVE5@1224|Proteobacteria,2V6WP@28211|Alphaproteobacteria,2JRJ8@204441|Rhodospirillales	204441|Rhodospirillales	E	Allophanate hydrolase subunit 1	-	-	-	-	-	-	-	-	-	-	-	-	CT_C_D
TLS3_k127_2275967_0	1380391.JIAS01000018_gene1016	2.676e-147	472.0	COG1984@1|root,COG1984@2|Bacteria,1MU9H@1224|Proteobacteria,2TS7P@28211|Alphaproteobacteria,2JQ6Z@204441|Rhodospirillales	204441|Rhodospirillales	E	Allophanate hydrolase subunit 2	-	-	-	-	-	-	-	-	-	-	-	-	CT_A_B
TLS3_k127_2275967_6	631454.N177_3854	8.776e-42	156.0	COG0640@1|root,COG0640@2|Bacteria,1PFU9@1224|Proteobacteria,2VACF@28211|Alphaproteobacteria,1JQG9@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_2275967_5	1161401.ASJA01000020_gene584	1.219e-49	186.0	COG3832@1|root,COG3832@2|Bacteria,1RA7N@1224|Proteobacteria,2U5AM@28211|Alphaproteobacteria,43ZZG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	MA20_01005	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_2275967_7	228405.HNE_3304	3.57e-17	82.0	2E54V@1|root,32ZXS@2|Bacteria,1N6QG@1224|Proteobacteria,2UG8S@28211|Alphaproteobacteria,440CS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2275967_4	1041159.AZUW01000006_gene1754	1.108e-58	206.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria,2U73S@28211|Alphaproteobacteria,4BDZF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_2275967_2	1282360.ABAC460_22485	1.947e-93	315.0	COG0625@1|root,COG0625@2|Bacteria,1NE6Z@1224|Proteobacteria,2TVN6@28211|Alphaproteobacteria,2KIFS@204458|Caulobacterales	204458|Caulobacterales	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
TLS3_k127_2275967_1	399739.Pmen_4336	6.585e-132	430.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,1RY9Y@1236|Gammaproteobacteria,1YGAU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TLS3_k127_2300307_2	1469613.JT55_00980	1.96e-183	582.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,3FCFR@34008|Rhodovulum	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TLS3_k127_2300307_5	1537715.JQFJ01000002_gene1837	6.096e-34	136.0	COG0454@1|root,COG0456@2|Bacteria,1RI35@1224|Proteobacteria,2UAGV@28211|Alphaproteobacteria,2K618@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03827	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
TLS3_k127_2300307_1	1188256.BASI01000001_gene705	6.997e-188	595.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,3FCHJ@34008|Rhodovulum	28211|Alphaproteobacteria	H	Mur ligase middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
TLS3_k127_2300307_3	1337093.MBE-LCI_2580	4.134e-151	484.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,2P857@245186|Loktanella	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_2300307_4	1530186.JQEY01000005_gene3631	3.592e-43	170.0	COG1266@1|root,COG1266@2|Bacteria,1QSFU@1224|Proteobacteria,2U5DX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CAAX amino terminal protease family protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS3_k127_2300307_0	1415756.JQMY01000001_gene1031	4.848e-317	977.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,2PCRV@252301|Oceanicola	28211|Alphaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS3_k127_2300307_6	1123501.KB902312_gene2544	5.313e-10	69.0	2DYBJ@1|root,32V55@2|Bacteria,1N1PF@1224|Proteobacteria,2UDHD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2312736_8	426117.M446_5904	6.282e-13	77.0	COG4961@1|root,COG4961@2|Bacteria,1PPJ4@1224|Proteobacteria,2V20V@28211|Alphaproteobacteria,1JXX1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS3_k127_2312736_7	1479238.JQMZ01000001_gene706	2.552e-44	181.0	COG4961@1|root,COG4961@2|Bacteria,1RI65@1224|Proteobacteria,2UA0U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS3_k127_2312736_5	195105.CN97_13425	1.97e-52	195.0	COG0741@1|root,COG0741@2|Bacteria,1RDXX@1224|Proteobacteria,2UCH1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS3_k127_2312736_10	1247963.JPHU01000009_gene2370	5.697e-09	61.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria	1224|Proteobacteria	U	Flp Fap pilin component	MA20_03885	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
TLS3_k127_2312736_6	1089552.KI911559_gene999	1.13e-45	177.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2TTPE@28211|Alphaproteobacteria,2JTIY@204441|Rhodospirillales	204441|Rhodospirillales	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
TLS3_k127_2312736_1	1089552.KI911559_gene998	1.501e-107	366.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,2JR67@204441|Rhodospirillales	204441|Rhodospirillales	U	Pilus formation protein N terminal region	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
TLS3_k127_2312736_9	1402135.SUH3_17300	5.224e-09	65.0	2AY36@1|root,31Q50@2|Bacteria,1RKKQ@1224|Proteobacteria,2U9CH@28211|Alphaproteobacteria,3ZYAN@60136|Sulfitobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2312736_2	1089552.KI911559_gene996	2.902e-79	280.0	COG4565@1|root,COG4963@1|root,COG4565@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,2JTJZ@204441|Rhodospirillales	204441|Rhodospirillales	U	Pilus assembly protein	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA
TLS3_k127_2312736_0	1089552.KI911559_gene995	4.881e-192	632.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,2JQHZ@204441|Rhodospirillales	204441|Rhodospirillales	U	Type II/IV secretion system protein	-	-	-	ko:K02283,ko:K20527	ko02024,map02024	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.7.4	-	-	T2SSE
TLS3_k127_2312736_4	1089552.KI911559_gene994	3.84e-57	216.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,2JRT7@204441|Rhodospirillales	204441|Rhodospirillales	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS3_k127_2312736_3	1089552.KI911559_gene993	1.138e-58	214.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria,2JRZQ@204441|Rhodospirillales	204441|Rhodospirillales	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS3_k127_2333606_3	1317118.ATO8_01925	7.615e-28	115.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,4KKPJ@93682|Roseivivax	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS3_k127_2333606_0	398580.Dshi_1078	3.203e-168	534.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TS0W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_2333606_2	351016.RAZWK3B_16525	5.496e-29	121.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2P3KU@2433|Roseobacter	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
TLS3_k127_2333606_1	1461694.ATO9_08220	4.173e-57	199.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,2PCW4@252301|Oceanicola	28211|Alphaproteobacteria	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS3_k127_2339493_1	1305735.JAFT01000005_gene2202	1.595e-56	210.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TTQ4@28211|Alphaproteobacteria,2PDGK@252301|Oceanicola	28211|Alphaproteobacteria	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
TLS3_k127_2339493_0	1469613.JT55_13600	9.761e-225	706.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,3FCJR@34008|Rhodovulum	28211|Alphaproteobacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS3_k127_2339493_2	748247.AZKH_1869	1.097e-48	180.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VQA1@28216|Betaproteobacteria,2KWJW@206389|Rhodocyclales	206389|Rhodocyclales	K	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS3_k127_2355115_1	398580.Dshi_0824	1.703e-90	316.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1R5C7@1224|Proteobacteria,2TS7V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
TLS3_k127_2355115_0	371731.Rsw2DRAFT_2583	1.303e-155	526.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,1FAQQ@1060|Rhodobacter	28211|Alphaproteobacteria	T	Two component, sigma54 specific transcriptional regulator, fis family	luxO	-	-	ko:K10912	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00513	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_2355115_2	1266998.ATUJ01000013_gene2335	1.497e-15	77.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,2PX5U@265|Paracoccus	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
TLS3_k127_2363357_0	391613.RTM1035_03550	2.31e-69	239.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,46P7S@74030|Roseovarius	28211|Alphaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS3_k127_2363357_3	551789.ATVJ01000001_gene2378	7.501e-42	167.0	COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,2U95R@28211|Alphaproteobacteria,43Y1T@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS3_k127_2363357_1	1469613.JT55_03695	5.159e-47	183.0	COG0546@1|root,COG0546@2|Bacteria,1RB0Z@1224|Proteobacteria,2U5DF@28211|Alphaproteobacteria,3FE25@34008|Rhodovulum	28211|Alphaproteobacteria	S	HAD-hyrolase-like	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_237566_8	349102.Rsph17025_0521	6.548e-38	147.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,1FARU@1060|Rhodobacter	28211|Alphaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
TLS3_k127_237566_6	398580.Dshi_0649	3.851e-41	154.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
TLS3_k127_237566_4	272943.RSP_0712	2.864e-83	280.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria,1FBN0@1060|Rhodobacter	28211|Alphaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
TLS3_k127_237566_3	1174684.EBMC1_01260	2.051e-102	351.0	COG2931@1|root,COG2931@2|Bacteria,1QYJ2@1224|Proteobacteria,2TY04@28211|Alphaproteobacteria,2K8VM@204457|Sphingomonadales	204457|Sphingomonadales	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
TLS3_k127_237566_9	195105.CN97_04490	4.062e-20	107.0	COG3009@1|root,COG3009@2|Bacteria,1RH03@1224|Proteobacteria,2U9EI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
TLS3_k127_237566_2	246200.SPO1249	4.898e-149	501.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2TSTX@28211|Alphaproteobacteria,4NBS6@97050|Ruegeria	28211|Alphaproteobacteria	Q	MlaD protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
TLS3_k127_237566_5	314265.R2601_27081	2.82e-72	251.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2TT3D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	paraquat-inducible protein A	pqiA	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
TLS3_k127_237566_7	1185766.DL1_17220	9.078e-41	161.0	COG2995@1|root,COG2995@2|Bacteria,1RAQ9@1224|Proteobacteria,2U6A1@28211|Alphaproteobacteria,2XMV1@285107|Thioclava	28211|Alphaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
TLS3_k127_237566_1	1415756.JQMY01000001_gene1567	5.431e-157	499.0	COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2TS3C@28211|Alphaproteobacteria,2PD3X@252301|Oceanicola	28211|Alphaproteobacteria	P	Polyamine ABC transporter, permease	potC	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS3_k127_237566_0	246200.SPO3474	3.702e-188	596.0	COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2TTJ6@28211|Alphaproteobacteria,4NA5S@97050|Ruegeria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS3_k127_2379632_1	314264.ROS217_13576	1.951e-64	229.0	COG3485@1|root,COG3485@2|Bacteria,1MV3B@1224|Proteobacteria,2TTZJ@28211|Alphaproteobacteria,46QNZ@74030|Roseovarius	28211|Alphaproteobacteria	Q	Dioxygenase	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
TLS3_k127_2379632_0	1569209.BBPH01000044_gene2114	3.899e-110	362.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,2PWJ6@265|Paracoccus	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
TLS3_k127_2379632_2	1121028.ARQE01000006_gene4477	1.799e-58	208.0	COG0599@1|root,COG2267@1|root,COG0599@2|Bacteria,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2TVZ2@28211|Alphaproteobacteria,2PJPS@255475|Aurantimonadaceae	28211|Alphaproteobacteria	I	Alpha/beta hydrolase family	pcaD	-	3.1.1.24,4.1.1.44	ko:K01055,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,CMD
TLS3_k127_2379632_3	1343740.M271_18775	2.479e-51	187.0	COG1082@1|root,COG3185@1|root,COG1082@2|Bacteria,COG3185@2|Bacteria,2GNF0@201174|Actinobacteria	201174|Actinobacteria	E	4-hydroxyphenylpyruvate dioxygenase	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AP_endonuc_2,Glyoxalase,Glyoxalase_5
TLS3_k127_2394563_9	1469613.JT55_06990	6.451e-18	93.0	2BKYU@1|root,32FFG@2|Bacteria,1RHT5@1224|Proteobacteria,2UA28@28211|Alphaproteobacteria,3FE8V@34008|Rhodovulum	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
TLS3_k127_2394563_1	1121271.AUCM01000013_gene2904	3.086e-177	565.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS3_k127_2394563_3	1121271.AUCM01000013_gene2903	2.856e-134	431.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	FeS assembly ATPase SufC	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS3_k127_2394563_0	1294273.roselon_03030	6.97e-300	929.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS3_k127_2394563_4	1449350.OCH239_01625	2.168e-121	407.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,4KMBB@93682|Roseivivax	28211|Alphaproteobacteria	E	Aminotransferase class-V	nifS	GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS3_k127_2394563_7	981384.AEYW01000006_gene2764	1.26e-65	228.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U5B9@28211|Alphaproteobacteria,4NA00@97050|Ruegeria	28211|Alphaproteobacteria	K	Transcriptional regulator	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
TLS3_k127_2394563_5	1469613.JT55_06950	7.725e-117	379.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,3FCQA@34008|Rhodovulum	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
TLS3_k127_2394563_6	1381123.AYOD01000036_gene3781	1.11e-65	235.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2U6DT@28211|Alphaproteobacteria,43RNQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS3_k127_2394563_2	1380350.JIAP01000001_gene1210	6.325e-150	481.0	COG2334@1|root,COG2334@2|Bacteria,1PGM7@1224|Proteobacteria,2TTGY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_2394563_8	1122247.C731_0240	1.238e-63	223.0	COG4577@1|root,COG4577@2|Bacteria,2GNG8@201174|Actinobacteria,2363R@1762|Mycobacteriaceae	201174|Actinobacteria	CQ	Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2394711_1	1417296.U879_02115	1.142e-152	490.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE_2	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_2394711_3	685778.AORL01000022_gene1434	8.035e-95	318.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2TRE6@28211|Alphaproteobacteria,2K1CX@204457|Sphingomonadales	204457|Sphingomonadales	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
TLS3_k127_2394711_2	1415756.JQMY01000001_gene3544	2.569e-138	451.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria,2PD7Q@252301|Oceanicola	28211|Alphaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	fghA	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
TLS3_k127_2394711_4	391613.RTM1035_19961	8.905e-61	216.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2U997@28211|Alphaproteobacteria,46NCU@74030|Roseovarius	28211|Alphaproteobacteria	S	Belongs to the UPF0178 family	MA20_27470	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
TLS3_k127_2394711_0	1461693.ATO10_06696	1.096e-181	578.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	bktB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_2394711_5	985054.JQEZ01000002_gene3696	6.619e-26	112.0	COG0784@1|root,COG0784@2|Bacteria,1REUP@1224|Proteobacteria,2U7HR@28211|Alphaproteobacteria,4NCG1@97050|Ruegeria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_2396246_0	935261.JAGL01000010_gene1929	5.841e-220	695.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,43J2M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS3_k127_2450763_0	1188256.BASI01000001_gene1021	1.485e-286	918.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3FDTT@34008|Rhodovulum	28211|Alphaproteobacteria	S	Alpha-2-Macroglobulin	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
TLS3_k127_2450763_2	1123360.thalar_00322	5.951e-71	249.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2TUA2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	bacC	-	1.1.1.159	ko:K00076	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS3_k127_2450763_1	1469613.JT55_09595	4.913e-104	345.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,3FD27@34008|Rhodovulum	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1013)	MA20_20925	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
TLS3_k127_2450763_3	34007.IT40_07225	1.934e-58	212.0	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,2PVCY@265|Paracoccus	28211|Alphaproteobacteria	J	Belongs to the RNase T2 family	rns	-	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
TLS3_k127_2450763_4	1547437.LL06_13505	3.043e-35	145.0	COG1051@1|root,COG1051@2|Bacteria,1N0YW@1224|Proteobacteria,2UC2E@28211|Alphaproteobacteria,43JZQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_2450763_5	1122223.KB890703_gene1303	1.172e-22	108.0	COG2520@1|root,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
TLS3_k127_2450763_6	136273.GY22_07410	3.41e-07	55.0	COG2207@1|root,COG2207@2|Bacteria,2IARM@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	virS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009268,GO:0009438,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046185,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051596,GO:0051716,GO:0060255,GO:0061727,GO:0065007,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072330,GO:0080090,GO:0104004,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
TLS3_k127_2476663_2	1472418.BBJC01000001_gene769	3.259e-37	140.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS3_k127_2476663_1	272943.RSP_1219	5.208e-56	203.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,1FBUP@1060|Rhodobacter	28211|Alphaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS3_k127_2476663_0	1122180.Lokhon_00679	3.579e-144	462.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,2P85M@245186|Loktanella	28211|Alphaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
TLS3_k127_2492174_1	1211115.ALIQ01000145_gene1024	1.022e-128	420.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,3N9T8@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	PFAM Electron transfer flavoprotein alpha beta-subunit	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS3_k127_2492174_0	1294273.roselon_01521	4.266e-129	419.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS3_k127_2518193_1	314270.RB2083_349	1.299e-08	65.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria,3ZGB6@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	M	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,T2SSE_N
TLS3_k127_2518193_0	272943.RSP_2660	9.225e-71	252.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,1FBYC@1060|Rhodobacter	28211|Alphaproteobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS3_k127_2540479_2	1211115.ALIQ01000171_gene4076	2.018e-50	183.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2TU7N@28211|Alphaproteobacteria,3N9WI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	sam	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
TLS3_k127_2540479_1	1469613.JT55_03500	6.207e-64	233.0	COG1664@1|root,COG1664@2|Bacteria,1MUS9@1224|Proteobacteria,2TSAA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_2540479_0	911045.PSE_2806	1.031e-100	335.0	COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,2TQST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.120,1.1.1.175,1.1.1.48	ko:K22185,ko:K22215	ko00040,ko00052,ko01100,map00040,map00052,map01100	-	R01094,R01097,R01429	RC00066,RC00161	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS3_k127_2573444_1	1396141.BATP01000037_gene3527	5.009e-40	156.0	COG0707@1|root,COG0707@2|Bacteria,46XJP@74201|Verrucomicrobia,2IW33@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Oligosaccharide biosynthesis protein Alg14 like	-	-	-	-	-	-	-	-	-	-	-	-	Alg14
TLS3_k127_2573444_2	196490.AUEZ01000001_gene7417	1.776e-36	147.0	COG5017@1|root,COG5017@2|Bacteria,1MZGV@1224|Proteobacteria,2UBWE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyltransferase family 28 C-terminal domain	pssE	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
TLS3_k127_2573444_0	323848.Nmul_A0256	1.192e-120	398.0	COG0673@1|root,COG0673@2|Bacteria,1PE87@1224|Proteobacteria,2W9B1@28216|Betaproteobacteria,374HB@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS3_k127_2585190_1	1123503.KB908059_gene255	5.769e-105	362.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	vieS	-	2.7.13.3	ko:K07679	ko02020,ko05133,map02020,map05133	M00477	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,Response_reg,SBP_bac_3
TLS3_k127_2585190_0	1381123.AYOD01000016_gene2686	2.393e-163	522.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria,43N4Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS3_k127_2585190_2	631454.N177_0232	6.665e-49	183.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,1JNNR@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
TLS3_k127_2630515_1	1336235.JAEG01000002_gene490	1.399e-91	306.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TT8F@28211|Alphaproteobacteria,4B7NQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, periplasmic component	frcB	-	-	ko:K10552	ko02010,map02010	M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.7	-	-	Peripla_BP_4
TLS3_k127_2630515_0	1449065.JMLL01000012_gene3668	1.304e-124	412.0	COG1940@1|root,COG2345@1|root,COG1940@2|Bacteria,COG2345@2|Bacteria,1MVGQ@1224|Proteobacteria,2TRFX@28211|Alphaproteobacteria,43I6N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
TLS3_k127_2630515_2	766499.C357_01939	1.318e-87	298.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_2630515_3	411684.HPDFL43_04435	1.657e-21	100.0	COG3788@1|root,COG3788@2|Bacteria,1PM83@1224|Proteobacteria,2UGJD@28211|Alphaproteobacteria,43Q0K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
TLS3_k127_2638666_4	1381123.AYOD01000015_gene2394	5.828e-139	445.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,43JH8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	livG1	-	-	ko:K01995,ko:K11957	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_2638666_5	349102.Rsph17025_0924	5.957e-124	400.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,1FB9Y@1060|Rhodobacter	28211|Alphaproteobacteria	E	PFAM ABC transporter	livF2	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS3_k127_2638666_2	1123229.AUBC01000008_gene397	2.807e-160	512.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSZP@28211|Alphaproteobacteria,3K4RM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2
TLS3_k127_2638666_0	1381123.AYOD01000015_gene2397	6.628e-174	572.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TUXZ@28211|Alphaproteobacteria,43JIU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_2638666_1	1123229.AUBC01000056_gene535	1.21e-160	533.0	COG2421@1|root,COG2421@2|Bacteria,1N12N@1224|Proteobacteria,2TV7V@28211|Alphaproteobacteria,3JUBD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Acetamidase/Formamidase family	MA20_08730	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
TLS3_k127_2638666_6	1123229.AUBC01000056_gene534	4.218e-108	370.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,2TUTU@28211|Alphaproteobacteria,3JVSJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_15935	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_2638666_3	1057002.KB905370_gene5000	1.873e-139	452.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TSKV@28211|Alphaproteobacteria,4B7JY@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldo keto reductase	tas	GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_2638666_7	1231392.OCGS_2231	1.653e-104	342.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS3_k127_2652272_1	314232.SKA53_10609	4.887e-101	336.0	COG2211@1|root,COG2211@2|Bacteria,1MWE4@1224|Proteobacteria,2TQY7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Major Facilitator	pucC2	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
TLS3_k127_2652272_0	1530186.JQEY01000005_gene3654	1.008e-178	582.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2TVK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	geranylgeranyl reductase	bchP	-	1.3.1.111,1.3.1.83	ko:K10960	ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R11226,R11518	RC00212,RC00522,RC01823	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Lycopene_cycl,NAD_binding_8,Pyr_redox_2
TLS3_k127_2652272_2	1449351.RISW2_22475	1.365e-69	250.0	COG1443@1|root,COG1443@2|Bacteria,1R9YJ@1224|Proteobacteria,2U5P8@28211|Alphaproteobacteria,4KMK0@93682|Roseivivax	28211|Alphaproteobacteria	I	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	idi	GO:0003674,GO:0003824,GO:0004452,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:1901576	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
TLS3_k127_2652272_3	1504672.669786362	6.606e-11	64.0	COG1216@1|root,COG1216@2|Bacteria,1QZE3@1224|Proteobacteria,2VYSG@28216|Betaproteobacteria,4AG8W@80864|Comamonadaceae	28216|Betaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_2678274_2	290397.Adeh_2255	6.187e-83	285.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,437TD@68525|delta/epsilon subdivisions,2WT6I@28221|Deltaproteobacteria,2YX1E@29|Myxococcales	28221|Deltaproteobacteria	C	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS3_k127_2678274_3	1238182.C882_0312	3.057e-70	244.0	COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,2VF54@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS3_k127_2678274_7	309801.trd_1042	4.296e-16	88.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,27XV7@189775|Thermomicrobia	189775|Thermomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS3_k127_2678274_6	1157708.KB907450_gene5900	3.464e-29	127.0	COG2186@1|root,COG2186@2|Bacteria,1MY1K@1224|Proteobacteria,2VRNN@28216|Betaproteobacteria,4AIV2@80864|Comamonadaceae	28216|Betaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_2678274_1	476272.RUMHYD_03477	1.76e-86	297.0	COG0371@1|root,COG0371@2|Bacteria,1V994@1239|Firmicutes	1239|Firmicutes	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH_2
TLS3_k127_2678274_0	1231185.BAMP01000054_gene4805	3.516e-98	346.0	COG1921@1|root,COG1921@2|Bacteria,1MW8F@1224|Proteobacteria,2TSR8@28211|Alphaproteobacteria,43RP0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	L-seryl-tRNA selenium transferase	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	SelA
TLS3_k127_2678274_4	1499967.BAYZ01000009_gene5385	8.131e-50	195.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_2678274_5	1499967.BAYZ01000067_gene6044	1.299e-38	151.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
TLS3_k127_268472_6	1122614.JHZF01000013_gene4064	1.886e-07	55.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2PD0C@252301|Oceanicola	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
TLS3_k127_268472_1	1410620.SHLA_4c000150	2.668e-68	243.0	COG2304@1|root,COG2304@2|Bacteria,1PH4N@1224|Proteobacteria,2TQTJ@28211|Alphaproteobacteria,4BB4P@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1194
TLS3_k127_268472_0	670292.JH26_13065	3.11e-183	581.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,1JT7F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS3_k127_268472_4	314264.ROS217_11681	7.377e-25	106.0	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2UBX6@28211|Alphaproteobacteria,46R14@74030|Roseovarius	28211|Alphaproteobacteria	N	Bacterial export proteins, family 3	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
TLS3_k127_268472_3	1417296.U879_15965	3.264e-25	107.0	COG1677@1|root,COG1677@2|Bacteria	2|Bacteria	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
TLS3_k127_268472_2	1415756.JQMY01000001_gene411	3.155e-43	163.0	COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2U94I@28211|Alphaproteobacteria,2PEF7@252301|Oceanicola	28211|Alphaproteobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS3_k127_268472_5	371731.Rsw2DRAFT_0397	1.139e-17	85.0	COG1815@1|root,COG1815@2|Bacteria,1N1G1@1224|Proteobacteria,2UCJ4@28211|Alphaproteobacteria,1FC20@1060|Rhodobacter	28211|Alphaproteobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
TLS3_k127_2711735_1	935565.JAEM01000001_gene303	6.288e-116	384.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,2PWUQ@265|Paracoccus	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_2711735_3	1417296.U879_18490	3.324e-59	214.0	COG1280@1|root,COG1280@2|Bacteria,1RET0@1224|Proteobacteria,2TT5R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	threonine efflux protein	MA20_02350	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS3_k127_2711735_2	398580.Dshi_2477	5.21e-61	213.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2U7XQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional Regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
TLS3_k127_2711735_0	1123060.JONP01000005_gene5574	9.57e-117	396.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TWIJ@28211|Alphaproteobacteria,2JTHF@204441|Rhodospirillales	204441|Rhodospirillales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_2714517_9	686340.Metal_2785	1.054e-22	99.0	COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1XFIZ@135618|Methylococcales	135618|Methylococcales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_2714517_6	1188256.BASI01000001_gene1434	2.772e-85	290.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2TSY8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	iclR	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS3_k127_2714517_1	935840.JAEQ01000019_gene2092	8.729e-181	573.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,43HFC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	PFAM aminotransferase	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS3_k127_2714517_2	351016.RAZWK3B_07614	4.174e-180	567.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2P238@2433|Roseobacter	28211|Alphaproteobacteria	E	COG1171 Threonine dehydratase	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_2714517_0	1185652.USDA257_c17700	4.189e-215	690.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,4B9GX@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	amino acid aldolase or racemase	dhaa	-	4.1.3.41	ko:K18425	-	-	-	-	ko00000,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
TLS3_k127_2714517_3	501479.ACNW01000106_gene4781	2.712e-154	493.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TT7X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ornithine cyclodeaminase	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS3_k127_2714517_5	1123060.JONP01000084_gene5278	2.629e-95	318.0	COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2U5JV@28211|Alphaproteobacteria,2JSDB@204441|Rhodospirillales	204441|Rhodospirillales	K	Putative FMN-binding domain	-	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
TLS3_k127_2714517_8	349102.Rsph17025_4248	1.862e-25	116.0	COG1279@1|root,COG1279@2|Bacteria,1RD6B@1224|Proteobacteria,2U583@28211|Alphaproteobacteria,1FC35@1060|Rhodobacter	28211|Alphaproteobacteria	S	LysE type translocator	argO	-	-	ko:K06895	-	-	-	-	ko00000,ko02000	2.A.75.1	-	-	LysE
TLS3_k127_2714517_4	367336.OM2255_03287	2.61e-103	340.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS3_k127_2714517_7	314256.OG2516_03213	6.219e-74	254.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,2PC8V@252301|Oceanicola	28211|Alphaproteobacteria	H	Molybdenum cofactor biosynthesis protein	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS3_k127_2721866_6	1446473.JHWH01000018_gene3712	9.973e-65	224.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U9GW@28211|Alphaproteobacteria,2PWGN@265|Paracoccus	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
TLS3_k127_2721866_5	1123237.Salmuc_02576	1.218e-65	241.0	COG2981@1|root,COG2981@2|Bacteria,1MWAA@1224|Proteobacteria,2TT6E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Protein involved in cysteine biosynthesis	MA20_24505	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	EI24
TLS3_k127_2721866_1	1121271.AUCM01000001_gene3550	2.1e-69	246.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase	ydjA	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS3_k127_2721866_2	195105.CN97_07120	1.893e-68	241.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	GO:0003674,GO:0003824,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_2721866_3	1530186.JQEY01000002_gene1662	1.112e-67	238.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2U6B7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0126
TLS3_k127_2721866_4	1121124.JNIX01000008_gene2337	3.247e-66	233.0	COG4430@1|root,COG4430@2|Bacteria,1NEN6@1224|Proteobacteria,2U849@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS3_k127_2721866_7	693986.MOC_2863	1.517e-19	98.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2U7UR@28211|Alphaproteobacteria,1JZBV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,Response_reg,cNMP_binding
TLS3_k127_2721866_0	754035.Mesau_05465	1.339e-105	350.0	COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,2TT7Q@28211|Alphaproteobacteria,43HEV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GM	epimerase dehydratase	-	-	4.1.1.35,5.1.3.10,5.1.3.2,5.1.3.25	ko:K01784,ko:K08678,ko:K12454,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R01384,R02984,R04266,R10279	RC00289,RC00508,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS3_k127_2730472_2	102125.Xen7305DRAFT_00050600	5.361e-81	299.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1G1JS@1117|Cyanobacteria,3VNJN@52604|Pleurocapsales	1117|Cyanobacteria	Q	Heme peroxidase family protein,putative calcium-binding protein	-	-	1.11.1.7	ko:K19511	-	-	-	-	ko00000,ko01000	-	-	-	An_peroxidase,HemolysinCabind
TLS3_k127_2730472_6	1337093.MBE-LCI_0113	1.836e-32	133.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2UCUE@28211|Alphaproteobacteria,2P95S@245186|Loktanella	28211|Alphaproteobacteria	L	nuclease	-	-	-	-	-	-	-	-	-	-	-	-	SNase
TLS3_k127_2730472_3	1294273.roselon_03143	1.805e-57	207.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS3_k127_2730472_0	1294273.roselon_03143	8.012e-149	488.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS3_k127_2730472_1	252305.OB2597_01417	1.375e-97	342.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,2PDP7@252301|Oceanicola	28211|Alphaproteobacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS3_k127_2730472_4	1461693.ATO10_01605	1.114e-56	205.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS3_k127_2730472_5	1123247.AUIJ01000009_gene3089	2.596e-47	176.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS3_k127_2738911_1	252305.OB2597_09779	4.774e-65	228.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Hydrogenase urease accessory protein	hupE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
TLS3_k127_2738911_3	83219.PM02_18115	1.109e-06	63.0	2EV28@1|root,33NHA@2|Bacteria,1NK90@1224|Proteobacteria,2UNAQ@28211|Alphaproteobacteria,3ZYZJ@60136|Sulfitobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2738911_0	420324.KI911970_gene1564	4.295e-303	942.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
TLS3_k127_2738911_2	314264.ROS217_13711	1.251e-34	146.0	COG2067@1|root,COG2067@2|Bacteria,1REWT@1224|Proteobacteria,2TXXB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2773787_6	1305735.JAFT01000001_gene13	2.921e-80	282.0	COG5621@1|root,COG5621@2|Bacteria,1QPJ4@1224|Proteobacteria,2TVNN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydroxyneurosporene synthase	crtC	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016122,GO:0016123,GO:0016829,GO:0016835,GO:0016836,GO:0018904,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046148,GO:0071704,GO:1901178,GO:1901180,GO:1901503,GO:1901576	4.2.1.131	ko:K09844	ko00906,ko01100,map00906,map01100	-	R07516,R07519,R07522,R07528,R07532,R07536,R07539,R07543,R09790	RC00966	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_2773787_2	1123237.Salmuc_00139	2.75e-138	456.0	COG1233@1|root,COG1233@2|Bacteria,1MX1C@1224|Proteobacteria,2TS2R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1233 Phytoene dehydrogenase and related proteins	crtD	-	1.3.99.27	ko:K09845	ko00906,ko01100,map00906,map01100	-	R07517,R07520,R07523,R07534	RC02080	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS3_k127_2773787_4	314232.SKA53_12318	4.418e-102	340.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TV46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	crtE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033385,GO:0033386,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS3_k127_2773787_5	1188256.BASI01000001_gene1006	5.644e-102	344.0	COG2230@1|root,COG2230@2|Bacteria,1QY5K@1224|Proteobacteria,2TXGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0500 SAM-dependent methyltransferases	crtF	-	2.1.1.210	ko:K09846	ko00906,ko01100,map00906,map01100	-	R07521,R07524,R07527,R07529,R07533,R07535	RC00003,RC02082	ko00000,ko00001,ko01000	-	-	-	Dimerisation2,Methyltransf_2
TLS3_k127_2773787_3	1188256.BASI01000001_gene1007	1.621e-134	436.0	COG1063@1|root,COG1063@2|Bacteria,1MVZC@1224|Proteobacteria,2TRM6@28211|Alphaproteobacteria,3FDP6@34008|Rhodovulum	28211|Alphaproteobacteria	E	Dehydrogenase	bchC	-	1.1.1.396	ko:K11337	ko00860,ko01110,map00860,map01110	-	R09055	RC01377	ko00000,ko00001,ko01000	-	-	-	ADH_N
TLS3_k127_2773787_0	1305735.JAFT01000001_gene18	8.765e-175	557.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2TSKC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP	bchX	-	1.3.7.14,1.3.7.15	ko:K11333	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000	-	-	-	Fer4_NifH
TLS3_k127_2773787_1	266809.PM03_13490	1.215e-144	464.0	COG2710@1|root,COG2710@2|Bacteria,1MUGI@1224|Proteobacteria,2TU7U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Chlorophyllide reductase subunit Y	bchY	-	1.3.7.14,1.3.7.15	ko:K11334	ko00860,ko01110,map00860,map01110	-	R09053,R09060	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro
TLS3_k127_2814608_3	272568.GDI1210	4.217e-148	479.0	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2TT7U@28211|Alphaproteobacteria,2JQ7G@204441|Rhodospirillales	204441|Rhodospirillales	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
TLS3_k127_2814608_4	1415756.JQMY01000001_gene3055	5.309e-121	394.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2TSP5@28211|Alphaproteobacteria,2PCIM@252301|Oceanicola	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS3_k127_2814608_1	1305735.JAFT01000005_gene1732	3.006e-166	527.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2TQV6@28211|Alphaproteobacteria,2PD6H@252301|Oceanicola	28211|Alphaproteobacteria	P	NMT1/THI5 like	thiY	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS3_k127_2814608_2	935261.JAGL01000010_gene1912	7.827e-152	508.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria,43IAT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS3_k127_2814608_0	384765.SIAM614_08763	1.384e-180	578.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	matB	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_2814608_5	1122218.KB893663_gene1589	5.941e-83	285.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria,1JS65@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
TLS3_k127_2814608_9	272943.RSP_0557	3.119e-08	59.0	COG5457@1|root,COG5457@2|Bacteria,1NHHX@1224|Proteobacteria,2UJ9Y@28211|Alphaproteobacteria,1FC79@1060|Rhodobacter	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1127
TLS3_k127_2814608_6	1188256.BASI01000002_gene3027	8.724e-72	250.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,3FD5M@34008|Rhodovulum	28211|Alphaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS3_k127_2814608_7	371731.Rsw2DRAFT_2630	2.006e-44	173.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,1FBPR@1060|Rhodobacter	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS3_k127_28272_2	1168059.KB899087_gene2831	3.823e-109	383.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2TU62@28211|Alphaproteobacteria,3EYJ5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS3_k127_28272_5	1207063.P24_10400	1.782e-12	78.0	2E3X5@1|root,32YUB@2|Bacteria,1N766@1224|Proteobacteria,2UFVD@28211|Alphaproteobacteria,2JU5G@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknwon function (DUF3008)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3008
TLS3_k127_28272_3	1120983.KB894571_gene2141	3.752e-92	321.0	COG1680@1|root,COG1680@2|Bacteria,1R8N7@1224|Proteobacteria,2UCNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS3_k127_28272_4	187272.Mlg_2182	4.584e-19	102.0	2E4J2@1|root,32ZE4@2|Bacteria,1N7YM@1224|Proteobacteria,1S4GF@1236|Gammaproteobacteria,1WY9W@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3775
TLS3_k127_28272_1	1411123.JQNH01000001_gene1124	6.947e-142	471.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM peptidase S10 serine carboxypeptidase	MA20_31445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
TLS3_k127_28272_0	412597.AEPN01000002_gene2860	3.186e-174	558.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2PVW1@265|Paracoccus	28211|Alphaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS3_k127_2834575_1	1123501.KB902280_gene480	5.854e-92	304.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	chvD	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_2834575_0	290400.Jann_1080	2.555e-278	872.0	COG1409@1|root,COG1409@2|Bacteria,1N44U@1224|Proteobacteria,2U456@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	N terminal of Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,MetallophosC,MetallophosN
TLS3_k127_2834575_2	1089551.KE386572_gene1877	6.251e-06	56.0	COG2885@1|root,COG2885@2|Bacteria,1RJ3P@1224|Proteobacteria,2U9ZX@28211|Alphaproteobacteria,4BSCM@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	OmpA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
TLS3_k127_2852180_3	1280681.AUJZ01000045_gene2511	4.211e-10	70.0	COG1705@1|root,COG3409@1|root,COG1705@2|Bacteria,COG3409@2|Bacteria,1V7JY@1239|Firmicutes,24C0T@186801|Clostridia,4C0SW@830|Butyrivibrio	186801|Clostridia	NU	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Amidase_3,CW_7,CW_binding_1,Cu_amine_oxidN1,Glucosaminidase,PG_binding_1
TLS3_k127_2852180_0	1123501.KB902298_gene3656	2.833e-76	266.0	COG3409@1|root,COG3409@2|Bacteria,1RFU4@1224|Proteobacteria,2U8C1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	N-acetylmuramidase	-	-	-	-	-	-	-	-	-	-	-	-	Muraidase,PG_binding_1
TLS3_k127_2852180_2	759362.KVU_2557	8.376e-44	173.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS3_k127_2852180_1	195105.CN97_19860	5.283e-64	224.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS3_k127_2853751_4	999547.KI421500_gene3749	2.393e-23	102.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,2TSAR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	uracil-DNA glycosylase	dpoL	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
TLS3_k127_2853751_1	1408224.SAMCCGM7_c3748	1.083e-123	413.0	COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2TTBK@28211|Alphaproteobacteria,4BA4P@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Polysaccharide biosynthesis protein	pssL	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
TLS3_k127_2853751_2	1408224.SAMCCGM7_c3735	1.096e-118	411.0	COG2273@1|root,COG2273@2|Bacteria,1Q6IY@1224|Proteobacteria,2TVH1@28211|Alphaproteobacteria,4BASH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2853751_3	412597.AEPN01000079_gene1346	3.763e-42	175.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2PV2I@265|Paracoccus	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_2853751_0	266779.Meso_4497	4.713e-169	542.0	COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2TRBE@28211|Alphaproteobacteria,43IZ2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Mannitol dehydrogenase	uxuB	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
TLS3_k127_2858429_0	224911.27351786	5.726e-223	701.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2TRKA@28211|Alphaproteobacteria,3JSZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS3_k127_2858429_1	349102.Rsph17025_1831	2.033e-153	491.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,1FCRP@1060|Rhodobacter	28211|Alphaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS3_k127_2858429_2	391626.OAN307_c26460	8.145e-14	72.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
TLS3_k127_2866900_2	195105.CN97_00165	2.439e-09	61.0	COG4643@1|root,COG4643@2|Bacteria,1N08G@1224|Proteobacteria,2TV40@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Protein of unknown function (DUF3987)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3987
TLS3_k127_2866900_0	224911.27351786	4.741e-222	698.0	COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2TRKA@28211|Alphaproteobacteria,3JSZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
TLS3_k127_2866900_1	349102.Rsph17025_1831	2.488e-103	359.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,1FCRP@1060|Rhodobacter	28211|Alphaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
TLS3_k127_2873520_1	1121271.AUCM01000004_gene1188	4.653e-79	271.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS3_k127_2873520_0	1417296.U879_16820	0.0	1249.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
TLS3_k127_2873520_2	1211777.BN77_4047	7.031e-29	134.0	COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2UG0P@28211|Alphaproteobacteria,4BE78@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_2877961_1	1288298.rosmuc_03097	8.403e-60	218.0	COG1075@1|root,COG1075@2|Bacteria,1R7C0@1224|Proteobacteria,2U52E@28211|Alphaproteobacteria,46QG2@74030|Roseovarius	28211|Alphaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF900
TLS3_k127_2877961_0	1469613.JT55_18560	8.609e-131	423.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,3FCG3@34008|Rhodovulum	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_2915790_3	384765.SIAM614_24847	2.725e-133	428.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS3_k127_2915790_1	1123229.AUBC01000019_gene4179	6.688e-226	710.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,3JS8Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS3_k127_2915790_5	398580.Dshi_2135	5.586e-60	215.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_27940	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_2915790_0	1188256.BASI01000005_gene1712	1.052e-267	829.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,3FCM9@34008|Rhodovulum	28211|Alphaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS3_k127_2915790_6	1231392.OCGS_0764	1.873e-52	199.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2TUVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	colicin V production	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TLS3_k127_2915790_2	1469613.JT55_12465	1.871e-198	627.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,3FCJM@34008|Rhodovulum	28211|Alphaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
TLS3_k127_2915790_4	252305.OB2597_00500	2.434e-109	363.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2PCBK@252301|Oceanicola	28211|Alphaproteobacteria	Q	ATPases associated with a variety of cellular activities	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS3_k127_2915790_7	367336.OM2255_06220	7.966e-41	152.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS3_k127_2919474_4	1500304.JQKY01000003_gene550	1.467e-48	176.0	COG4803@1|root,COG4803@2|Bacteria,1RAJ2@1224|Proteobacteria,2U6M7@28211|Alphaproteobacteria,4BBUE@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
TLS3_k127_2919474_1	765698.Mesci_6283	9.931e-162	525.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VF1X@28211|Alphaproteobacteria,43NU8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K18988	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF3471
TLS3_k127_2919474_2	765698.Mesci_6284	2.724e-145	471.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VF1X@28211|Alphaproteobacteria,43NU8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K18988	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF3471
TLS3_k127_2919474_0	1161401.ASJA01000001_gene562	4.404e-169	551.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,43XB8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
TLS3_k127_2919474_3	1121271.AUCM01000003_gene1649	3.078e-142	471.0	COG0079@1|root,COG0079@2|Bacteria,1MWPU@1224|Proteobacteria,2TRV5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase	hisC1	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_2927306_0	34007.IT40_22845	5.113e-269	846.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2PVTK@265|Paracoccus	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS3_k127_2927306_1	1188256.BASI01000005_gene2110	6.769e-85	318.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,3FD1F@34008|Rhodovulum	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	MA20_24420	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
TLS3_k127_2927306_2	762376.AXYL_03554	3.396e-80	276.0	COG1876@1|root,COG1876@2|Bacteria	2|Bacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	B_lectin,PG_binding_1,VanY
TLS3_k127_2927306_6	1294273.roselon_03266	0.0002127	46.0	2E6I5@1|root,3315B@2|Bacteria,1N6WY@1224|Proteobacteria,2UF81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2927306_4	981384.AEYW01000023_gene3805	6.041e-31	124.0	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,4NCNC@97050|Ruegeria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2312)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2312
TLS3_k127_2927306_3	1101190.ARWB01000001_gene3115	1.736e-43	169.0	COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,2UA6G@28211|Alphaproteobacteria,3702N@31993|Methylocystaceae	28211|Alphaproteobacteria	L	DNA mismatch endonuclease Vsr	-	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Vsr
TLS3_k127_2927306_5	394221.Mmar10_1019	7.071e-24	104.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria,43XN9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
TLS3_k127_2939715_2	1122218.KB893653_gene564	4.225e-27	114.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,1JSBN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM PHB accumulation regulatory domain	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
TLS3_k127_2939715_5	1245471.PCA10_26700	0.000213	46.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS3_k127_2939715_0	1121271.AUCM01000009_gene2104	3.865e-59	216.0	COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,2TT4R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	EAL domain	yfgF	-	-	-	-	-	-	-	-	-	-	-	EAL
TLS3_k127_2939715_1	1449350.OCH239_01765	1.365e-52	189.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,4KMN7@93682|Roseivivax	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
TLS3_k127_2939715_3	1157708.KB907451_gene4864	8.144e-22	98.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4ABWU@80864|Comamonadaceae	28216|Betaproteobacteria	T	Adenylate cyclase	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
TLS3_k127_2981688_3	483219.LILAB_18865	2.701e-36	143.0	COG4912@1|root,COG4912@2|Bacteria,1RGVM@1224|Proteobacteria,42ZZV@68525|delta/epsilon subdivisions,2WVCM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS3_k127_2981688_2	999547.KI421500_gene828	2.826e-93	312.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,27ZMT@191028|Leisingera	28211|Alphaproteobacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TLS3_k127_2981688_4	666509.RCA23_c13340	1.318e-26	110.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2UF3C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
TLS3_k127_2981688_0	1449351.RISW2_22745	4.443e-222	704.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,4KM4X@93682|Roseivivax	28211|Alphaproteobacteria	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
TLS3_k127_2981688_1	1342301.JASD01000008_gene1440	7.827e-96	321.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,3ZVUX@60136|Sulfitobacter	28211|Alphaproteobacteria	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS3_k127_298748_1	1449065.JMLL01000010_gene881	2.37e-169	543.0	COG4310@1|root,COG4310@2|Bacteria,1NDWT@1224|Proteobacteria,2TTYP@28211|Alphaproteobacteria,43MMY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF2172)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2172,DUF4910,HTH_47,Peptidase_M28
TLS3_k127_298748_4	1532558.JL39_12650	5.758e-84	287.0	COG2227@1|root,COG2227@2|Bacteria,1RAQ6@1224|Proteobacteria,2U62S@28211|Alphaproteobacteria,4BDSS@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
TLS3_k127_298748_0	1040983.AXAE01000004_gene733	2.341e-183	587.0	COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,2TUKG@28211|Alphaproteobacteria,43MUV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
TLS3_k127_298748_2	439375.Oant_3391	1.385e-128	438.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria,1J1HI@118882|Brucellaceae	28211|Alphaproteobacteria	JM	Glucose-1-phosphate cytidylyltransferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
TLS3_k127_298748_5	1122132.AQYH01000003_gene3041	1.304e-76	276.0	COG2120@1|root,COG2120@2|Bacteria,1MX2V@1224|Proteobacteria,2TT5F@28211|Alphaproteobacteria,4BC39@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS3_k127_298748_3	572477.Alvin_1965	3.338e-113	389.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS3_k127_298748_6	1122180.Lokhon_02175	2.972e-35	141.0	COG0457@1|root,COG1216@1|root,COG0457@2|Bacteria,COG1216@2|Bacteria,1R1ZZ@1224|Proteobacteria,2TZGV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
TLS3_k127_2988474_2	1123237.Salmuc_05620	2.096e-43	165.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS3_k127_2988474_1	391624.OIHEL45_01035	8.661e-86	294.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1253 Hemolysins and related proteins containing CBS domains	tlyC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
TLS3_k127_2988474_0	195105.CN97_01835	1.535e-125	423.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
TLS3_k127_2991841_0	935848.JAEN01000004_gene1303	2.732e-148	493.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,2PWK8@265|Paracoccus	28211|Alphaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS3_k127_2991841_1	314256.OG2516_09473	8.254e-121	398.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,2PD88@252301|Oceanicola	28211|Alphaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
TLS3_k127_2991841_2	420324.KI911948_gene9246	8.727e-59	231.0	COG2461@1|root,COG3920@1|root,COG2461@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2TX95@28211|Alphaproteobacteria,1JYYN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_3,PAS_4,PAS_9
TLS3_k127_2993573_0	371731.Rsw2DRAFT_1582	6.182e-103	352.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,1FB46@1060|Rhodobacter	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	sun1	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
TLS3_k127_2993573_1	1367847.JCM7686_1339	1.535e-77	264.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,2PUS2@265|Paracoccus	28211|Alphaproteobacteria	K	CarD-like/TRCF domain	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS3_k127_3004359_2	1469613.JT55_12390	6.408e-76	259.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2U6G5@28211|Alphaproteobacteria,3FDWV@34008|Rhodovulum	28211|Alphaproteobacteria	D	VirC1 protein	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	CbiA
TLS3_k127_3004359_1	398580.Dshi_1339	1.502e-107	355.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_19195	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_3004359_0	349102.Rsph17025_1984	3.473e-156	503.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,1FBPV@1060|Rhodobacter	28211|Alphaproteobacteria	P	PFAM ABC transporter	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS3_k127_3007769_2	314264.ROS217_07505	6.575e-56	203.0	28JVS@1|root,2Z9KP@2|Bacteria,1R74U@1224|Proteobacteria,2U1XR@28211|Alphaproteobacteria,46RSW@74030|Roseovarius	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3007769_1	314264.ROS217_07625	5.146e-59	217.0	COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,2UDFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_3007769_0	118168.MC7420_7338	2.544e-66	239.0	2DTTJ@1|root,32UVW@2|Bacteria,1G8TS@1117|Cyanobacteria,1HCTF@1150|Oscillatoriales	1117|Cyanobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS3_k127_3008654_1	1547437.LL06_09480	1.348e-71	252.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,43HT3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2189)	MA20_04950	-	-	-	-	-	-	-	-	-	-	-	DUF2189
TLS3_k127_3008654_2	1317124.DW2_10559	7.217e-48	177.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,2XNAV@285107|Thioclava	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_3008654_0	398580.Dshi_1176	1.337e-91	313.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	MA20_30780	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_3011911_3	595537.Varpa_1467	1.295e-30	123.0	COG5552@1|root,COG5552@2|Bacteria,1MZBV@1224|Proteobacteria,2VVJM@28216|Betaproteobacteria,4AEUN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS3_k127_3011911_2	1469613.JT55_17155	7.499e-54	203.0	COG1564@1|root,COG1564@2|Bacteria,1RE29@1224|Proteobacteria,2U7FB@28211|Alphaproteobacteria,3FE22@34008|Rhodovulum	28211|Alphaproteobacteria	H	Thiamin pyrophosphokinase, vitamin B1 binding domain	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
TLS3_k127_3011911_1	1122218.KB893663_gene1666	2.992e-60	213.0	COG3045@1|root,COG3045@2|Bacteria,1RDMP@1224|Proteobacteria,2U72F@28211|Alphaproteobacteria,1JT4W@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM CreA family protein	creA	-	-	ko:K05805	-	-	-	-	ko00000	-	-	-	CreA
TLS3_k127_3011911_4	398580.Dshi_2741	2.609e-24	106.0	2CA50@1|root,32YIT@2|Bacteria,1N822@1224|Proteobacteria,2UFR0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2842
TLS3_k127_3011911_0	195105.CN97_06625	9.633e-84	279.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS3_k127_3074426_1	398580.Dshi_0036	1.064e-128	415.0	COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Exodeoxyribonuclease III	xthA2	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS3_k127_3074426_3	1231185.BAMP01000121_gene990	8.076e-15	77.0	2CAE1@1|root,33CHP@2|Bacteria,1NIX1@1224|Proteobacteria,2UK24@28211|Alphaproteobacteria,43MD9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3074426_0	1449351.RISW2_19260	1.224e-151	490.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,4KMFG@93682|Roseivivax	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	acuI	-	1.1.1.1	ko:K00001,ko:K19745	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R00919,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00095,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_3074426_2	1446473.JHWH01000008_gene136	7.56e-59	220.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria,2PWJS@265|Paracoccus	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS3_k127_3104614_1	1121271.AUCM01000012_gene2971	6.399e-122	402.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2TSYS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS3_k127_3104614_0	1188256.BASI01000001_gene1241	4.645e-159	530.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,3FCS1@34008|Rhodovulum	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS3_k127_3111985_1	1469613.JT55_01440	4.149e-85	286.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,3FCH2@34008|Rhodovulum	28211|Alphaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS3_k127_3111985_0	1569209.BBPH01000078_gene1128	1.751e-103	343.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,2PUQK@265|Paracoccus	28211|Alphaproteobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
TLS3_k127_3111985_2	349102.Rsph17025_0399	2.86e-27	116.0	COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,1FBTA@1060|Rhodobacter	28211|Alphaproteobacteria	L	Belongs to the DnaA family	hda	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA
TLS3_k127_3124784_3	1122180.Lokhon_01740	5.051e-36	154.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2U08T@28211|Alphaproteobacteria,2P90X@245186|Loktanella	28211|Alphaproteobacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291,ko:K18163	ko00906,ko01062,ko01100,ko01110,ko04714,map00906,map01062,map01100,map01110,map04714	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	SQS_PSY
TLS3_k127_3124784_0	1121271.AUCM01000008_gene3280	6.896e-260	811.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSK4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	MA20_26350	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS3_k127_3124784_1	371731.Rsw2DRAFT_1263	1.259e-160	522.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,1FAYN@1060|Rhodobacter	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
TLS3_k127_3124784_2	1282360.ABAC460_05950	1.424e-39	153.0	COG2315@1|root,COG2315@2|Bacteria,1RHEZ@1224|Proteobacteria,2U97K@28211|Alphaproteobacteria,2KH5B@204458|Caulobacterales	204458|Caulobacterales	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS3_k127_3138353_4	768671.ThimaDRAFT_2790	2.865e-12	67.0	COG1394@1|root,COG1394@2|Bacteria,1RJCN@1224|Proteobacteria,1S7QV@1236|Gammaproteobacteria,1WY6C@135613|Chromatiales	135613|Chromatiales	C	subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
TLS3_k127_3138353_0	765913.ThidrDRAFT_3266	4.688e-152	502.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RY40@1236|Gammaproteobacteria,1WXJ9@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
TLS3_k127_3138353_2	985054.JQEZ01000001_gene2378	3.959e-28	132.0	COG0636@1|root,COG0636@2|Bacteria,1RB4B@1224|Proteobacteria,2USIX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
TLS3_k127_3138353_3	768671.ThimaDRAFT_2788	1.058e-15	77.0	COG0636@1|root,COG0636@2|Bacteria,1RB4B@1224|Proteobacteria,1S2I4@1236|Gammaproteobacteria,1WY0G@135613|Chromatiales	135613|Chromatiales	C	subunit c	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
TLS3_k127_3138353_1	765913.ThidrDRAFT_3268	3.714e-42	162.0	COG1390@1|root,COG1390@2|Bacteria,1MYFC@1224|Proteobacteria,1S1YK@1236|Gammaproteobacteria,1WWH9@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
TLS3_k127_3138882_3	1417296.U879_10920	6.111e-74	252.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
TLS3_k127_3138882_5	195105.CN97_08825	2.574e-61	220.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	nucleic-acid-binding protein implicated in transcription termination	MA20_23920	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448,Ribosomal_L7Ae
TLS3_k127_3138882_0	1461693.ATO10_06091	0.0	1044.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
TLS3_k127_3138882_2	419610.Mext_0062	2.592e-78	269.0	COG1335@1|root,COG1335@2|Bacteria,1RF03@1224|Proteobacteria,2U7S1@28211|Alphaproteobacteria,1JRN0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS3_k127_3138882_4	1297569.MESS2_1650031	2.871e-65	236.0	298NJ@1|root,2ZVT4@2|Bacteria,1RE4U@1224|Proteobacteria,2U80S@28211|Alphaproteobacteria,43PJV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3138882_1	981384.AEYW01000024_gene3971	2.221e-113	389.0	COG4249@1|root,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TR94@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
TLS3_k127_3138882_6	765911.Thivi_3431	0.0005671	49.0	COG0845@1|root,COG0845@2|Bacteria,1R0RK@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3165098_2	1535287.JP74_05810	5.691e-96	320.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TR7P@28211|Alphaproteobacteria,3N7QE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	FGGY family of carbohydrate kinases, C-terminal domain	xylB	GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_3165098_1	1121939.L861_04890	1.598e-140	452.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XHD1@135619|Oceanospirillales	135619|Oceanospirillales	S	transporter substrate-binding protein	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
TLS3_k127_3165098_3	1121939.L861_04885	2.165e-25	123.0	COG4729@1|root,COG4729@2|Bacteria,1N3QP@1224|Proteobacteria,1SAH9@1236|Gammaproteobacteria,1XPN4@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain of unknown function (DUF1850)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1850
TLS3_k127_3165098_0	42565.FP66_00640	5.769e-186	592.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1XH5B@135619|Oceanospirillales	135619|Oceanospirillales	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS3_k127_3174783_2	1317124.DW2_05225	1.558e-28	122.0	COG4392@1|root,COG4392@2|Bacteria,1MZUZ@1224|Proteobacteria,2UC31@28211|Alphaproteobacteria,2XNFY@285107|Thioclava	28211|Alphaproteobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
TLS3_k127_3174783_1	1415756.JQMY01000001_gene977	7.591e-43	163.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,2PE77@252301|Oceanicola	28211|Alphaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS3_k127_3174783_0	1188256.BASI01000001_gene522	0.0	1032.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,3FCW8@34008|Rhodovulum	28211|Alphaproteobacteria	J	B3/4 domain	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS3_k127_3194031_0	398580.Dshi_0001	1.916e-264	819.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
TLS3_k127_3194031_2	1469613.JT55_00585	3.229e-40	153.0	COG3791@1|root,COG3791@2|Bacteria,1N0KM@1224|Proteobacteria,2UBTK@28211|Alphaproteobacteria,3FEEE@34008|Rhodovulum	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_3194031_1	290400.Jann_0251	3.658e-42	159.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS3_k127_3195333_1	1415756.JQMY01000001_gene1505	1.66e-24	108.0	2AJ0U@1|root,319IW@2|Bacteria,1RGWP@1224|Proteobacteria,2U9I9@28211|Alphaproteobacteria,2PEH0@252301|Oceanicola	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3195333_0	1417296.U879_12990	4.539e-266	831.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
TLS3_k127_3232051_6	1305735.JAFT01000005_gene527	1.527e-42	164.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,2PDH0@252301|Oceanicola	28211|Alphaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
TLS3_k127_3232051_5	195105.CN97_10760	1.798e-71	255.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS3_k127_3232051_1	371731.Rsw2DRAFT_2866	7.652e-149	477.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,1FAST@1060|Rhodobacter	28211|Alphaproteobacteria	F	Cell wall formation	ddl	-	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS3_k127_3232051_3	880072.Desac_0670	3.387e-124	418.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,42N40@68525|delta/epsilon subdivisions,2WKUV@28221|Deltaproteobacteria,2MRT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the alkaline phosphatase family	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
TLS3_k127_3232051_2	1469613.JT55_02620	2.173e-127	415.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,3FCT7@34008|Rhodovulum	28211|Alphaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS3_k127_3232051_7	1120949.KB903333_gene1517	1.093e-38	161.0	COG2519@1|root,COG2519@2|Bacteria,2I40X@201174|Actinobacteria,4DMHF@85008|Micromonosporales	201174|Actinobacteria	J	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS3_k127_3232051_0	314264.ROS217_23532	6.01e-219	704.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,46PR7@74030|Roseovarius	28211|Alphaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_3232051_4	1417296.U879_18095	6.478e-91	309.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS3_k127_32382_2	1292034.OR37_01707	5.774e-52	187.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,2KFJ0@204458|Caulobacterales	204458|Caulobacterales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
TLS3_k127_32382_3	195105.CN97_17490	2.288e-30	136.0	COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_32382_0	1122614.JHZF01000013_gene3345	2.051e-221	704.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,2PCM7@252301|Oceanicola	28211|Alphaproteobacteria	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
TLS3_k127_32382_1	1185766.DL1_17745	7.813e-97	323.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,2XMNM@285107|Thioclava	28211|Alphaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS3_k127_3239397_0	991905.SL003B_3825	4.821e-249	780.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,4BPSG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	MA20_16190	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
TLS3_k127_3239397_1	195105.CN97_01755	7.297e-130	417.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	transglutaminase domain protein	MA20_16195	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
TLS3_k127_3239592_13	34007.IT40_23930	4.037e-07	55.0	COG5591@1|root,COG5591@2|Bacteria,1N6RP@1224|Proteobacteria,2UFFA@28211|Alphaproteobacteria,2PXP6@265|Paracoccus	28211|Alphaproteobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
TLS3_k127_3239592_8	631454.N177_2737	1.277e-52	195.0	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VGBI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
TLS3_k127_3239592_9	1417296.U879_16790	9.126e-42	161.0	COG2197@1|root,COG2197@2|Bacteria,1RDUR@1224|Proteobacteria,2U7E1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	COG2771 DNA-binding HTH domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS3_k127_3239592_0	1417296.U879_14490	0.0	1814.0	COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2TQXU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
TLS3_k127_3239592_12	991905.SL003B_2976	9.568e-14	82.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2U81X@28211|Alphaproteobacteria,4BQYK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologues	-	-	-	-	-	-	-	-	-	-	-	-	SNase
TLS3_k127_3239592_2	375451.RD1_1868	7.94e-162	532.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2P2Q3@2433|Roseobacter	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.12,6.2.1.3	ko:K01897,ko:K01904	ko00061,ko00071,ko00130,ko00360,ko00940,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00130,map00360,map00940,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00039,M00086,M00137,M00350	R01280,R01616,R01943,R02194,R02221,R02255,R06583	RC00004,RC00014,RC00131	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS3_k127_3239592_5	1123237.Salmuc_03577	9.533e-67	236.0	COG0517@1|root,COG0517@2|Bacteria,1QVXV@1224|Proteobacteria,2U5IK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS3_k127_3239592_1	358220.C380_01685	7.443e-238	756.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,4ABGN@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM glucose-methanol-choline oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_3239592_10	1121106.JQKB01000034_gene5981	2.405e-32	147.0	COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,2UC1E@28211|Alphaproteobacteria,2JTT3@204441|Rhodospirillales	204441|Rhodospirillales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS3_k127_3239592_4	1449350.OCH239_12795	1.299e-102	348.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	mdoC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0008150,GO:0008152,GO:0009311,GO:0016020,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0044238,GO:0044464,GO:0071704,GO:0071944	-	ko:K11941	-	-	-	-	ko00000,ko01000	-	-	-	Acyl_transf_3
TLS3_k127_3239592_11	391593.RCCS2_10135	4.388e-28	124.0	2E7B7@1|root,331UM@2|Bacteria,1RDQR@1224|Proteobacteria,2U7SQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3239592_7	195105.CN97_05895	1.061e-56	210.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS3_k127_3239592_6	1417296.U879_06565	3.425e-59	211.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
TLS3_k127_3239592_3	1415756.JQMY01000001_gene1990	5.545e-114	371.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,2PDDJ@252301|Oceanicola	28211|Alphaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
TLS3_k127_3240945_1	1231392.OCGS_2320	1.809e-25	117.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	oligoketide cyclase lipid transport protein	pasT	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
TLS3_k127_3240945_0	1535287.JP74_08440	5.685e-96	316.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2TTN7@28211|Alphaproteobacteria,3N8ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS3_k127_3257814_4	856793.MICA_2020	2.547e-05	56.0	COG3420@1|root,COG3420@2|Bacteria,1QXVM@1224|Proteobacteria	1224|Proteobacteria	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565
TLS3_k127_3257814_3	1530186.JQEY01000001_gene697	1.727e-12	72.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS3_k127_3257814_2	1449351.RISW2_17190	4.794e-60	236.0	COG1475@1|root,COG1475@2|Bacteria,1MY4B@1224|Proteobacteria,2U47Z@28211|Alphaproteobacteria,4KNAX@93682|Roseivivax	28211|Alphaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS3_k127_3257814_0	195105.CN97_02020	6.215e-233	729.0	COG1192@1|root,COG1192@2|Bacteria,1MVJU@1224|Proteobacteria,2TRYQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	COG1192 ATPases involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS3_k127_3257814_1	1342301.JASD01000003_gene12	2.572e-131	432.0	COG5534@1|root,COG5534@2|Bacteria,1MXQ0@1224|Proteobacteria,2TRBV@28211|Alphaproteobacteria,3ZWKU@60136|Sulfitobacter	28211|Alphaproteobacteria	L	Replication initiator protein A	-	-	-	-	-	-	-	-	-	-	-	-	RPA
TLS3_k127_3265348_1	1121271.AUCM01000005_gene796	4.764e-88	317.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS3_k127_3265348_0	349102.Rsph17025_0196	3.926e-109	367.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,1FAPM@1060|Rhodobacter	28211|Alphaproteobacteria	K	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18
TLS3_k127_3265348_2	420324.KI912047_gene3842	7.712e-71	245.0	COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,2U1H0@28211|Alphaproteobacteria,1JUB8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS3_k127_3280905_1	1449351.RISW2_12460	1.033e-53	196.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,4KKJ2@93682|Roseivivax	28211|Alphaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
TLS3_k127_3280905_0	1530186.JQEY01000009_gene2900	3.291e-96	327.0	COG3021@1|root,COG3021@2|Bacteria,1MWFK@1224|Proteobacteria,2U1VS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_3280905_2	1101189.AQUO01000001_gene3411	2.571e-11	67.0	2EMS8@1|root,33FEP@2|Bacteria,1NJ54@1224|Proteobacteria,2UJC6@28211|Alphaproteobacteria,2PXJI@265|Paracoccus	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3280905_3	1089551.KE386572_gene4583	9.733e-05	46.0	2C4KB@1|root,32YM4@2|Bacteria,1N74A@1224|Proteobacteria,2UHJ4@28211|Alphaproteobacteria,4BT5T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3299215_1	759362.KVU_2220	2.181e-48	190.0	COG1846@1|root,COG1846@2|Bacteria,1RD9U@1224|Proteobacteria,2U7NF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS3_k127_3299215_0	1417296.U879_11155	2.943e-107	359.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.77	ko:K01459,ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
TLS3_k127_3299215_2	644076.SCH4B_3228	5.654e-35	138.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,4NCN2@97050|Ruegeria	28211|Alphaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
TLS3_k127_3299215_3	1089551.KE386572_gene602	1.788e-10	62.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,4BQIJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphoribosyl transferase domain	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS3_k127_3299480_1	1569209.BBPH01000171_gene453	2.178e-79	273.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TTBX@28211|Alphaproteobacteria,2PZ5G@265|Paracoccus	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_3299480_0	1469613.JT55_06795	7.671e-306	967.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,3FCVY@34008|Rhodovulum	28211|Alphaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
TLS3_k127_3304287_0	1288298.rosmuc_00010	5.832e-191	608.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,46QKI@74030|Roseovarius	28211|Alphaproteobacteria	J	Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS3_k127_3304287_1	570952.ATVH01000014_gene1866	3.342e-21	93.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2JQ0Z@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS3_k127_3338777_1	1123229.AUBC01000006_gene973	4.648e-112	368.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,2TU5N@28211|Alphaproteobacteria,3JUHK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
TLS3_k127_3338777_2	1123229.AUBC01000006_gene974	0.0009758	51.0	2EQBZ@1|root,33HY3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3338777_0	1417296.U879_07495	1.828e-187	609.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TLS3_k127_3344199_0	272943.RSP_1020	1.499e-252	786.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,1FBEA@1060|Rhodobacter	28211|Alphaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS3_k127_3344199_3	1123072.AUDH01000006_gene3270	0.0001071	55.0	2DR7Y@1|root,33AM1@2|Bacteria,1R3AX@1224|Proteobacteria,2UH1W@28211|Alphaproteobacteria,2JZ7D@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3253)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3253
TLS3_k127_3344199_1	314271.RB2654_17626	1.179e-248	786.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	MA20_44660	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
TLS3_k127_3344199_2	314256.OG2516_16901	4.762e-247	781.0	28H8H@1|root,2Z7KE@2|Bacteria,1MV77@1224|Proteobacteria,2TSVV@28211|Alphaproteobacteria,2PCGD@252301|Oceanicola	28211|Alphaproteobacteria	S	Aerotolerance regulator N-terminal	MA20_44655	-	-	-	-	-	-	-	-	-	-	-	BatA,DUF4159
TLS3_k127_3344846_4	388399.SSE37_17173	0.0006963	48.0	2AGAB@1|root,316FU@2|Bacteria,1RHRI@1224|Proteobacteria,2U96E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Controls the rotational direction of flagella during chemotaxis	fliL2	-	-	-	-	-	-	-	-	-	-	-	FliL
TLS3_k127_3344846_2	1449351.RISW2_22665	9.485e-60	222.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TRHN@28211|Alphaproteobacteria,4KMCU@93682|Roseivivax	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
TLS3_k127_3344846_3	985054.JQEZ01000003_gene1326	9.544e-35	141.0	COG1261@1|root,COG1261@2|Bacteria,1PM4C@1224|Proteobacteria,2TRUS@28211|Alphaproteobacteria,4NCFJ@97050|Ruegeria	28211|Alphaproteobacteria	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly	flgA	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
TLS3_k127_3344846_0	1469613.JT55_00310	5.585e-120	405.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2TRR4@28211|Alphaproteobacteria,3FCX9@34008|Rhodovulum	28211|Alphaproteobacteria	N	Flagella basal body rod protein	flgG	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS3_k127_3344846_1	272943.RSP_1327	1.89e-73	257.0	COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,2U06G@28211|Alphaproteobacteria,1FBPQ@1060|Rhodobacter	28211|Alphaproteobacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	flgF	-	-	ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS3_k127_335393_2	1525715.IX54_01585	6.856e-74	254.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,2PWEH@265|Paracoccus	28211|Alphaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
TLS3_k127_335393_6	1449350.OCH239_09525	3.336e-28	124.0	COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,4KMX9@93682|Roseivivax	28211|Alphaproteobacteria	S	Membrane fusogenic activity	MA20_05375	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
TLS3_k127_335393_3	398580.Dshi_2646	7.969e-65	226.0	COG5465@1|root,COG5465@2|Bacteria,1REC1@1224|Proteobacteria,2U7UP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative bacterial sensory transduction regulator	MA20_05485	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS3_k127_335393_1	195105.CN97_01720	2.919e-96	322.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS3_k127_335393_7	570967.JMLV01000010_gene1181	1.385e-20	99.0	COG5490@1|root,COG5490@2|Bacteria,1MZ74@1224|Proteobacteria,2UCS0@28211|Alphaproteobacteria,2JTK7@204441|Rhodospirillales	204441|Rhodospirillales	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
TLS3_k127_335393_5	1122614.JHZF01000011_gene2110	4.21e-49	184.0	COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,2U9AH@28211|Alphaproteobacteria,2PEAK@252301|Oceanicola	28211|Alphaproteobacteria	J	Putative tRNA binding domain	csaA	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
TLS3_k127_335393_0	1041142.ATTP01000001_gene1923	6.18e-99	332.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,4B80B@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR2	-	1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81	ko:K00015,ko:K00050,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R00717,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_335393_4	864069.MicloDRAFT_00068750	6.241e-52	188.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,1JV4E@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS3_k127_3356207_2	1122218.KB893654_gene2051	1.49e-36	140.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,1JRES@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
TLS3_k127_3356207_0	1530186.JQEY01000008_gene2999	1.452e-82	287.0	COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,2TUVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_3356207_3	314271.RB2654_08527	1.064e-25	112.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2UF4D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS3_k127_3356207_1	246200.SPOA0076	1.985e-40	155.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,2TVMQ@28211|Alphaproteobacteria,4NA8I@97050|Ruegeria	28211|Alphaproteobacteria	S	Hydrolase, carbon-nitrogen family	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_3374645_2	398580.Dshi_0930	5.956e-195	634.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	MA20_07375	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
TLS3_k127_3374645_0	1123247.AUIJ01000018_gene2673	0.0	1182.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_3374645_3	266779.Meso_1477	4.121e-26	113.0	COG2155@1|root,COG2155@2|Bacteria,1N77I@1224|Proteobacteria,2UESE@28211|Alphaproteobacteria,43QB8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF378)	-	-	-	ko:K09779	-	-	-	-	ko00000	-	-	-	DUF378
TLS3_k127_3374645_1	1123501.KB902310_gene253	2.912e-203	637.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS3_k127_3374645_5	1381123.AYOD01000006_gene1135	6.068e-16	82.0	COG5591@1|root,COG5591@2|Bacteria,1N7TH@1224|Proteobacteria,2UMID@28211|Alphaproteobacteria,43M2K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
TLS3_k127_3374645_4	252305.OB2597_01937	2.23e-18	90.0	COG1426@1|root,COG1426@2|Bacteria,1MYWX@1224|Proteobacteria,2TQM2@28211|Alphaproteobacteria,2PCB7@252301|Oceanicola	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
TLS3_k127_3380509_3	414684.RC1_0053	8.976e-49	177.0	COG4643@1|root,COG5545@1|root,COG4643@2|Bacteria,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,2U0ID@28211|Alphaproteobacteria,2JVCN@204441|Rhodospirillales	204441|Rhodospirillales	S	Virulence-associated protein E	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_3,VirE
TLS3_k127_3380509_4	1123237.Salmuc_04414	2.836e-32	143.0	COG3218@1|root,COG3218@2|Bacteria,1RI22@1224|Proteobacteria,2UB1D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system auxiliary component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
TLS3_k127_3380509_0	1231392.OCGS_0914	4.207e-124	417.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents periplasmic component	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS3_k127_3380509_1	195105.CN97_16635	7.889e-121	398.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC transporter	yrbF	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
TLS3_k127_3380509_2	1231392.OCGS_0916	4.269e-107	355.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	MA20_08115	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS,STAS_2
TLS3_k127_3384456_2	1185766.DL1_20005	8.752e-94	314.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,2XKYE@285107|Thioclava	28211|Alphaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS3_k127_3384456_1	195105.CN97_00555	9.776e-136	447.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
TLS3_k127_3384456_0	349102.Rsph17025_2146	7.77e-210	677.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,1FBDP@1060|Rhodobacter	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
TLS3_k127_3389121_0	1415756.JQMY01000001_gene2375	2.965e-116	383.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,2PDD3@252301|Oceanicola	28211|Alphaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
TLS3_k127_3389121_3	1121479.AUBS01000001_gene3275	8.08e-35	138.0	COG1714@1|root,COG1714@2|Bacteria,1P9TI@1224|Proteobacteria,2TRIS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane protein domain	MA20_36685	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS3_k127_3389121_1	314265.R2601_25631	9.248e-108	357.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	polyphosphate kinase	ppk_2	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0042802,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS3_k127_3389121_2	1530186.JQEY01000008_gene2995	1.056e-56	206.0	COG2267@1|root,COG2267@2|Bacteria,1MW9H@1224|Proteobacteria,2U1YC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_3393610_0	1469613.JT55_04070	0.0	1217.0	COG3391@1|root,COG3391@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,3FDUE@34008|Rhodovulum	28211|Alphaproteobacteria	S	GTA TIM-barrel-like domain	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM,Phage-tail_3
TLS3_k127_3393610_2	1101189.AQUO01000001_gene1011	7.809e-07	59.0	2AMVY@1|root,31CSS@2|Bacteria,1Q9MB@1224|Proteobacteria,2V4U8@28211|Alphaproteobacteria,2PXVD@265|Paracoccus	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3393610_1	290400.Jann_2684	7.748e-20	95.0	2BWZZ@1|root,2Z7V7@2|Bacteria,1PFGK@1224|Proteobacteria,2TUWA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2927)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2927
TLS3_k127_3396919_2	314256.OG2516_10014	2.761e-94	333.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria,2PDW6@252301|Oceanicola	28211|Alphaproteobacteria	N	FlhB HrpN YscU SpaS Family	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
TLS3_k127_3396919_3	1188256.BASI01000001_gene454	2.9e-64	230.0	COG1684@1|root,COG1684@2|Bacteria,1R6NQ@1224|Proteobacteria,2VGAB@28211|Alphaproteobacteria,3FDED@34008|Rhodovulum	28211|Alphaproteobacteria	N	Bacterial export proteins, family 1	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
TLS3_k127_3396919_0	1417296.U879_15915	1.153e-294	919.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
TLS3_k127_3396919_4	195105.CN97_13425	3.978e-53	197.0	COG0741@1|root,COG0741@2|Bacteria,1RDXX@1224|Proteobacteria,2UCH1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS3_k127_3396919_1	1002340.AFCF01000066_gene382	1.335e-136	454.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U0RN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Animal haem peroxidase	-	-	1.11.1.7	ko:K19511	-	-	-	-	ko00000,ko01000	-	-	-	An_peroxidase,HemolysinCabind
TLS3_k127_3396990_1	1317118.ATO8_00120	9.704e-197	634.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,4KKJR@93682|Roseivivax	28211|Alphaproteobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS3_k127_3396990_3	398580.Dshi_1795	6.483e-120	407.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
TLS3_k127_3396990_5	765698.Mesci_5412	2.941e-93	316.0	COG1917@1|root,COG3631@1|root,COG1917@2|Bacteria,COG3631@2|Bacteria,1N7QJ@1224|Proteobacteria,2UFRZ@28211|Alphaproteobacteria,43RUY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	Cupin_2,SnoaL_2
TLS3_k127_3396990_0	1122214.AQWH01000012_gene3741	7.439e-212	664.0	COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,2TUCZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1
TLS3_k127_3396990_2	384765.SIAM614_24857	3.097e-159	506.0	COG1175@1|root,COG1175@2|Bacteria,1MU84@1224|Proteobacteria,2TRM5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport systems permease components	amyD	-	-	ko:K17316	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
TLS3_k127_3396990_4	1122214.AQWH01000012_gene3739	1.379e-98	341.0	COG0395@1|root,COG0395@2|Bacteria,1MUT9@1224|Proteobacteria,2TRQ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026,ko:K17317	ko02010,map02010	M00207,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
TLS3_k127_3397293_1	1188256.BASI01000005_gene1750	2.575e-53	191.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,3FCZH@34008|Rhodovulum	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_3397293_2	999549.KI421513_gene2774	9.697e-14	81.0	2E56U@1|root,32ZZI@2|Bacteria,1N750@1224|Proteobacteria,2UF4W@28211|Alphaproteobacteria,281P5@191028|Leisingera	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3397293_0	441620.Mpop_2263	7.747e-184	583.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,2TSAR@28211|Alphaproteobacteria,1JS83@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Uracil-DNA glycosylase superfamily	MA20_15960	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
TLS3_k127_3405422_3	266809.PM03_11370	1.519e-14	83.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS3_k127_3405422_0	391595.RLO149_c025720	2.466e-175	556.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,2P287@2433|Roseobacter	28211|Alphaproteobacteria	D	COG0772 Bacterial cell division membrane protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
TLS3_k127_3405422_2	1082933.MEA186_28202	1.89e-21	95.0	COG3360@1|root,COG3360@2|Bacteria,1N6YT@1224|Proteobacteria,2UFPQ@28211|Alphaproteobacteria,43M7Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TLS3_k127_3405422_1	338966.Ppro_2756	3.106e-43	173.0	2AK27@1|root,31ARV@2|Bacteria,1NMHV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3414485_0	1121033.AUCF01000009_gene1018	5.97e-288	927.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JQS7@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS3_k127_3414485_1	266779.Meso_2228	8.938e-125	409.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,43H7U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CJ	COG1042 Acyl-CoA synthetase (NDP forming)	MA20_38090	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS3_k127_3422561_0	1469613.JT55_13895	5.557e-126	417.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,3FCU9@34008|Rhodovulum	28211|Alphaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS3_k127_3422561_1	1469613.JT55_13890	1.253e-70	246.0	COG1600@1|root,COG1600@2|Bacteria,1R9XX@1224|Proteobacteria,2UA5Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1145 Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3422561_2	376733.IT41_13540	9e-39	168.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,2PVA7@265|Paracoccus	28211|Alphaproteobacteria	T	Phosphoglycerate mutase family	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS3_k127_3457828_9	1082933.MEA186_17993	6.479e-48	176.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSTD@28211|Alphaproteobacteria,43HJ0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	araH	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_3457828_4	34007.IT40_03025	9.878e-110	361.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,2PVWD@265|Paracoccus	28211|Alphaproteobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	deoD	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS3_k127_3457828_5	1168059.KB899087_gene2448	6.326e-107	359.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2TU6F@28211|Alphaproteobacteria,3F18H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
TLS3_k127_3457828_3	266809.PM03_00345	1.447e-118	388.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane transporter protein	MA20_19835	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_3457828_8	1417296.U879_07545	7.341e-67	249.0	2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transmembrane protein (Alph_Pro_TM)	MA20_19830	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
TLS3_k127_3457828_6	314232.SKA53_10744	3.971e-103	345.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,2TSNZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ion transport protein	ccaA	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
TLS3_k127_3457828_1	316057.RPD_3255	4.904e-155	499.0	COG1506@1|root,COG1506@2|Bacteria,1R3T5@1224|Proteobacteria,2U0MA@28211|Alphaproteobacteria,3JS2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Hydrolase_4
TLS3_k127_3457828_0	1121271.AUCM01000002_gene3887	5.943e-214	675.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,2TQWC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member	-	-	3.1.11.5	ko:K01144	-	-	-	-	ko00000,ko01000	-	-	-	AAA_30,UvrD_C_2
TLS3_k127_3457828_7	501479.ACNW01000046_gene181	2.532e-85	287.0	COG3916@1|root,COG3916@2|Bacteria,1MWPW@1224|Proteobacteria,2TVJ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Acyl-homoserine-lactone synthase	raiI	-	2.3.1.184	ko:K20249	ko00270,ko01100,ko02024,map00270,map01100,map02024	-	R08940	RC00021,RC00039	ko00000,ko00001,ko01000	-	-	-	Autoind_synth
TLS3_k127_3457828_2	246200.SPO2128	5.461e-152	490.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,4NBAQ@97050|Ruegeria	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_3457828_10	314265.R2601_23795	1.542e-21	109.0	COG0122@1|root,COG0400@1|root,COG0122@2|Bacteria,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2TTWP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Phospholipase Carboxylesterase	estB	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS3_k127_3464025_4	1337093.MBE-LCI_1954	2.82e-22	98.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2P8HS@245186|Loktanella	28211|Alphaproteobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
TLS3_k127_3464025_1	371731.Rsw2DRAFT_0624	6.875e-99	338.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,1FB7W@1060|Rhodobacter	28211|Alphaproteobacteria	H	TIGRFAM 5,10-methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_3464025_3	1417296.U879_07835	1.502e-37	145.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria,2UBTM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
TLS3_k127_3464025_0	1121479.AUBS01000001_gene3561	9.564e-105	353.0	COG0685@1|root,COG0685@2|Bacteria,1MVWT@1224|Proteobacteria,2TTSF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0685 5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_3464025_2	1380391.JIAS01000002_gene3187	4.595e-46	185.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2U1D1@28211|Alphaproteobacteria,2JSI1@204441|Rhodospirillales	204441|Rhodospirillales	S	Haloacid dehalogenase-like hydrolase	cbbY	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS3_k127_3470764_1	1089551.KE386572_gene3872	4.06e-189	617.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS3_k127_3470764_2	1089551.KE386572_gene3873	7.216e-113	368.0	COG1028@1|root,COG1028@2|Bacteria,1MX8B@1224|Proteobacteria,2U26N@28211|Alphaproteobacteria,4BS22@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_18145	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_3470764_0	1112216.JH594425_gene446	8.414e-196	617.0	COG2017@1|root,COG2017@2|Bacteria,1MVUY@1224|Proteobacteria,2U3XD@28211|Alphaproteobacteria,2K2UW@204457|Sphingomonadales	204457|Sphingomonadales	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
TLS3_k127_3490895_3	1121033.AUCF01000024_gene217	5.577e-130	417.0	COG0687@1|root,COG0687@2|Bacteria,1PRWU@1224|Proteobacteria,2U2MI@28211|Alphaproteobacteria,2JQQG@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
TLS3_k127_3490895_2	1125973.JNLC01000010_gene1148	1.086e-145	471.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3JTXD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
TLS3_k127_3490895_4	1121033.AUCF01000024_gene215	5.334e-127	421.0	COG1176@1|root,COG1176@2|Bacteria,1NNYP@1224|Proteobacteria,2U084@28211|Alphaproteobacteria,2JRNR@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS3_k127_3490895_5	1120792.JAFV01000001_gene1308	5.176e-120	392.0	COG1177@1|root,COG1177@2|Bacteria,1R29Z@1224|Proteobacteria,2TQM5@28211|Alphaproteobacteria,36ZNC@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS3_k127_3490895_0	266835.14026363	0.0	1118.0	COG4909@1|root,COG4909@2|Bacteria,1R4F8@1224|Proteobacteria,2U15Y@28211|Alphaproteobacteria,43N7X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Dehydratase large subunit	-	-	4.2.1.28	ko:K01699	ko00640,map00640	-	R02376	RC00707	ko00000,ko00001,ko01000	-	-	-	Dehydratase_LU,Dehydratase_MU
TLS3_k127_3490895_10	1121033.AUCF01000024_gene221	1.14e-35	157.0	COG4910@1|root,COG4910@2|Bacteria,1R96C@1224|Proteobacteria,2UAWD@28211|Alphaproteobacteria,2JTSU@204441|Rhodospirillales	204441|Rhodospirillales	Q	Dehydratase small subunit	-	-	-	-	-	-	-	-	-	-	-	-	Dehydratase_SU
TLS3_k127_3490895_8	717785.HYPMC_3788	2.808e-102	349.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUNB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS3_k127_3490895_6	1040983.AXAE01000008_gene166	9.069e-120	390.0	COG1028@1|root,COG1028@2|Bacteria,1MWCY@1224|Proteobacteria,2TT44@28211|Alphaproteobacteria,43N9K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_3490895_9	1057002.KB905370_gene3723	1.773e-100	340.0	COG1609@1|root,COG1609@2|Bacteria,1MXQ1@1224|Proteobacteria,2U3YE@28211|Alphaproteobacteria,4B9QT@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K03435	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_4
TLS3_k127_3490895_1	644076.SCH4B_3817	1.162e-152	490.0	COG1879@1|root,COG1879@2|Bacteria,1MUAT@1224|Proteobacteria,2U2VQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
TLS3_k127_3490895_7	1297569.MESS2_p60013	3.332e-109	362.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,43GZV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_3506881_1	1122614.JHZF01000011_gene1962	1.708e-58	216.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,2PDE5@252301|Oceanicola	28211|Alphaproteobacteria	M	Peptidase family M23	MA20_30780	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_3506881_2	414684.RC1_1625	7.438e-57	216.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2JS6P@204441|Rhodospirillales	204441|Rhodospirillales	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS3_k127_3506881_0	716928.AJQT01000013_gene1294	3.561e-67	249.0	COG4335@1|root,COG4335@2|Bacteria,1P0C1@1224|Proteobacteria,2TV47@28211|Alphaproteobacteria,4B9ZF@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS3_k127_3508912_1	1370122.JHXQ01000021_gene2256	4.796e-105	359.0	COG0745@1|root,COG3920@1|root,COG0745@2|Bacteria,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2TSSQ@28211|Alphaproteobacteria,4B7N7@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	fsrR	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,Response_reg
TLS3_k127_3508912_2	1156935.QWE_04938	2.704e-66	246.0	COG3437@1|root,COG3437@2|Bacteria,1QXI4@1224|Proteobacteria,2TXB8@28211|Alphaproteobacteria,4BNUY@82115|Rhizobiaceae	28211|Alphaproteobacteria	KT	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_3508912_0	349102.Rsph17025_1341	3.212e-117	388.0	COG0642@1|root,COG5278@1|root,COG0642@2|Bacteria,COG5278@2|Bacteria,1NXDJ@1224|Proteobacteria,2TX0U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA
TLS3_k127_3509022_5	1461694.ATO9_02550	1.933e-23	101.0	COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,2PE35@252301|Oceanicola	28211|Alphaproteobacteria	F	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
TLS3_k127_3509022_0	314265.R2601_14220	2.944e-210	661.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
TLS3_k127_3509022_3	1122180.Lokhon_00625	1.814e-56	224.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,2P8QP@245186|Loktanella	28211|Alphaproteobacteria	D	COG4942 Membrane-bound metallopeptidase	filA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_3509022_1	376733.IT41_17000	1.596e-207	658.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria,2PUN6@265|Paracoccus	28211|Alphaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
TLS3_k127_3509022_6	1367847.JCM7686_3464	1.067e-09	66.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2PY9Q@265|Paracoccus	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,HemolysinCabind,LTD
TLS3_k127_3509022_2	1305735.JAFT01000005_gene907	2.697e-117	385.0	COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria,2PEIS@252301|Oceanicola	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fixR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_3509022_4	371731.Rsw2DRAFT_3238	7.775e-50	184.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,1FBUM@1060|Rhodobacter	28211|Alphaproteobacteria	K	PFAM Cold-shock	cspC	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS3_k127_350997_3	1269813.ATUL01000001_gene1102	2.954e-09	69.0	COG1943@1|root,COG1943@2|Bacteria,1P8IT@1224|Proteobacteria,1RSQC@1236|Gammaproteobacteria,1WWSI@135613|Chromatiales	135613|Chromatiales	L	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
TLS3_k127_350997_1	1380394.JADL01000010_gene4341	3.457e-79	278.0	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2TSP3@28211|Alphaproteobacteria,2JRSB@204441|Rhodospirillales	204441|Rhodospirillales	M	effector of murein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	LrgB
TLS3_k127_350997_2	519989.ECTPHS_12169	1.949e-22	107.0	COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,1SDBW@1236|Gammaproteobacteria,1WYVC@135613|Chromatiales	135613|Chromatiales	S	PFAM LrgA	-	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
TLS3_k127_350997_0	1354722.JQLS01000008_gene2471	1.517e-160	512.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,46NF9@74030|Roseovarius	28211|Alphaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS3_k127_3510531_2	1449076.JOOE01000001_gene2448	8.937e-101	336.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VFDU@28211|Alphaproteobacteria,2K48Y@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS3_k127_3510531_0	1231392.OCGS_1260	7.443e-129	417.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS3_k127_3510531_3	1234595.C725_2271	6.488e-89	305.0	COG3920@1|root,COG3920@2|Bacteria,1MXWD@1224|Proteobacteria,2TUVS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,PAS_4,PAS_8,PAS_9
TLS3_k127_3510531_5	1449049.JONW01000005_gene1381	5.08e-12	75.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_3510531_1	1123247.AUIJ01000001_gene1693	1.381e-113	368.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2TQS5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	scoB	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS3_k127_3510531_4	1121028.ARQE01000001_gene3610	6.521e-78	276.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,2TRWI@28211|Alphaproteobacteria,2PK7I@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
TLS3_k127_3511863_0	314271.RB2654_12554	1.209e-320	996.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS3_k127_3511863_1	595536.ADVE02000001_gene2064	3.045e-06	57.0	2EJ3S@1|root,33CV1@2|Bacteria,1PUNS@1224|Proteobacteria,2V68J@28211|Alphaproteobacteria,3714J@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3518162_9	1266909.AUAG01000025_gene1847	5.537e-44	162.0	COG4636@1|root,COG4636@2|Bacteria,1RCFH@1224|Proteobacteria,1S3NE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_3518162_5	331869.BAL199_14477	1.345e-75	265.0	COG0212@1|root,COG0212@2|Bacteria,1RAZI@1224|Proteobacteria,2U6UH@28211|Alphaproteobacteria,4BS7I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	5-formyltetrahydrofolate cyclo-ligase family	-	-	-	-	-	-	-	-	-	-	-	-	5-FTHF_cyc-lig
TLS3_k127_3518162_3	1469245.JFBG01000056_gene2447	2.04e-84	289.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,1WXHP@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
TLS3_k127_3518162_1	1469245.JFBG01000056_gene2448	3.868e-133	441.0	COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,1RZTV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_3518162_6	1469245.JFBG01000056_gene2449	1.161e-74	258.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1WVXE@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
TLS3_k127_3518162_0	1121413.JMKT01000003_gene180	1.419e-181	586.0	COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,42PP5@68525|delta/epsilon subdivisions,2WMQR@28221|Deltaproteobacteria,2M8D9@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
TLS3_k127_3518162_2	257310.BB4044	5.631e-129	426.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2VIKG@28216|Betaproteobacteria,3T20H@506|Alcaligenaceae	28216|Betaproteobacteria	S	Oxidoreductase	lhgO	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS3_k127_3518162_8	419610.Mext_4644	1.67e-49	183.0	COG4636@1|root,COG4636@2|Bacteria,1RHNE@1224|Proteobacteria,2U9GQ@28211|Alphaproteobacteria,1JSJS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_3518162_4	1121106.JQKB01000036_gene725	2.71e-77	278.0	COG0367@1|root,COG0367@2|Bacteria,1NNHE@1224|Proteobacteria	1224|Proteobacteria	E	asparagine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3518162_7	684949.ATTJ01000003_gene3179	4.841e-65	225.0	COG4091@1|root,COG4091@2|Bacteria	2|Bacteria	-	-	strU	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF,Shikimate_DH
TLS3_k127_3526102_2	1500257.JQNM01000010_gene593	2.578e-106	351.0	COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,2TR3Q@28211|Alphaproteobacteria,4B8S5@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Xanthine dehydrogenase	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
TLS3_k127_3526102_0	1408224.SAMCCGM7_c3666	0.0	1172.0	COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,2TTAB@28211|Alphaproteobacteria,4BC7X@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_3526102_3	1057002.KB905370_gene3271	7.042e-70	259.0	COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,2TU5J@28211|Alphaproteobacteria,4B7Q8@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	xdhC	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS3_k127_3526102_1	1535287.JP74_12000	4.156e-140	456.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,3N7I7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	ATPases associated with a variety of cellular activities	MA20_34815	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_3531026_1	1054213.HMPREF9946_00942	1.961e-97	339.0	COG1404@1|root,COG1404@2|Bacteria,1N6B3@1224|Proteobacteria,2U3Y1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS3_k127_3531026_0	371731.Rsw2DRAFT_1795	2.493e-171	548.0	COG4857@1|root,COG4857@2|Bacteria,1MXBW@1224|Proteobacteria,2TR0Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate	mtnK	-	2.7.1.100	ko:K00899	ko00270,ko01100,map00270,map01100	M00034	R04143	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
TLS3_k127_3531026_3	1500257.JQNM01000009_gene865	6.697e-18	98.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2V8W2@28211|Alphaproteobacteria,4BF2R@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_3531026_2	1541065.JRFE01000014_gene1481	8.43e-64	243.0	COG2133@1|root,COG2931@1|root,COG2133@2|Bacteria,COG2931@2|Bacteria,1G2CB@1117|Cyanobacteria,3VM5E@52604|Pleurocapsales	1117|Cyanobacteria	GQ	Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,GSDH,Laminin_G_3,Lectin_C
TLS3_k127_3542214_6	1337093.MBE-LCI_1719	3.003e-14	81.0	29KTS@1|root,307R7@2|Bacteria,1N8YZ@1224|Proteobacteria,2UH2V@28211|Alphaproteobacteria,2P9SZ@245186|Loktanella	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3542214_5	272943.RSP_2085	8.555e-25	108.0	2E4VN@1|root,33KMW@2|Bacteria,1NIA0@1224|Proteobacteria,2UM4K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3542214_0	1317118.ATO8_04696	4.335e-311	967.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,4KMDS@93682|Roseivivax	28211|Alphaproteobacteria	KL	DEAD-like helicases superfamily	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
TLS3_k127_3542214_4	331869.BAL199_05139	9.682e-28	126.0	COG3238@1|root,COG3238@2|Bacteria	2|Bacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
TLS3_k127_3542214_3	391937.NA2_19146	1.957e-55	207.0	COG0454@1|root,COG0456@2|Bacteria,1RBE6@1224|Proteobacteria,2U9H8@28211|Alphaproteobacteria,43PH5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS3_k127_3542214_1	991905.SL003B_3430	1.016e-68	238.0	COG1396@1|root,COG1396@2|Bacteria,1Q1NG@1224|Proteobacteria,2U79V@28211|Alphaproteobacteria,4BQZ9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	MA20_22200	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
TLS3_k127_3542214_2	376733.IT41_04710	1.097e-60	219.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2U5A0@28211|Alphaproteobacteria,2PVD9@265|Paracoccus	28211|Alphaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
TLS3_k127_3557989_3	1294273.roselon_00153	2.097e-22	102.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria	1224|Proteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0003674,GO:0005215	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS3_k127_3557989_2	439497.RR11_3426	7.286e-25	109.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,4NBXI@97050|Ruegeria	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0003674,GO:0005215	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS3_k127_3557989_1	388739.RSK20926_16432	5.698e-103	349.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,2P1W6@2433|Roseobacter	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS3_k127_3557989_0	1415756.JQMY01000001_gene2774	6.371e-111	381.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2TTFE@28211|Alphaproteobacteria,2PCB6@252301|Oceanicola	28211|Alphaproteobacteria	S	Protein of unknown function (DUF815)	MA20_41470	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
TLS3_k127_3575938_3	571166.KI421509_gene736	3.35e-12	67.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	UPF0056 membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
TLS3_k127_3575938_1	1188256.BASI01000002_gene3396	4.466e-39	153.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VG8P@28211|Alphaproteobacteria,3FDIW@34008|Rhodovulum	28211|Alphaproteobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
TLS3_k127_3575938_0	391589.RGAI101_2546	2.862e-52	196.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,2P2PF@2433|Roseobacter	28211|Alphaproteobacteria	M	COG1560 Lauroyl myristoyl acyltransferase	msbB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS3_k127_3575938_2	414684.RC1_1058	1.08e-27	121.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,2JRCJ@204441|Rhodospirillales	204441|Rhodospirillales	V	MatE	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_3579482_0	398580.Dshi_0125	1.292e-265	826.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQV0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
TLS3_k127_3579482_1	1211115.ALIQ01000149_gene356	2.424e-146	469.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,2TRRX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS3_k127_3587475_3	1122614.JHZF01000011_gene1980	1.861e-84	291.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2TRRV@28211|Alphaproteobacteria,2PDD5@252301|Oceanicola	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
TLS3_k127_3587475_2	314256.OG2516_12491	1.479e-119	393.0	COG0346@1|root,COG0346@2|Bacteria,1P6TT@1224|Proteobacteria,2TQXR@28211|Alphaproteobacteria,2PE2F@252301|Oceanicola	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	mhqO	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS3_k127_3587475_4	935261.JAGL01000019_gene586	6.333e-65	241.0	COG0400@1|root,COG0400@2|Bacteria,1MUKQ@1224|Proteobacteria,2TUA0@28211|Alphaproteobacteria,43RQK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Phospholipase Carboxylesterase	mhqD	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,DLH
TLS3_k127_3587475_0	398580.Dshi_3491	1.17e-238	752.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_3587475_5	670292.JH26_17750	6.298e-46	171.0	2DMKA@1|root,32S5N@2|Bacteria,1N1W8@1224|Proteobacteria,2UC4K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SPW
TLS3_k127_3587475_1	1211115.ALIQ01000116_gene4706	7.15e-160	525.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3NBSI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
TLS3_k127_3587475_6	272943.RSP_2382	2.543e-44	179.0	2CFNJ@1|root,32S24@2|Bacteria,1N1K9@1224|Proteobacteria,2UDHS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3618)	ndiB	-	-	-	-	-	-	-	-	-	-	-	DUF3618
TLS3_k127_3587475_7	272943.RSP_2383	2.464e-37	147.0	2E4S1@1|root,32ZKH@2|Bacteria,1N9PR@1224|Proteobacteria,2UFAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS3_k127_3587475_8	272943.RSP_6050	1.907e-18	96.0	2EJM3@1|root,33DC0@2|Bacteria,1NGP8@1224|Proteobacteria,2UKSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3598455_0	483219.LILAB_30600	5.56e-61	241.0	COG0845@1|root,COG0845@2|Bacteria,1R7QT@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3614529_12	1040989.AWZU01000039_gene6129	3.412e-16	90.0	COG1925@1|root,COG1925@2|Bacteria,1N8YC@1224|Proteobacteria,2UGFF@28211|Alphaproteobacteria,3JZIV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	PTS HPr component phosphorylation site	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TLS3_k127_3614529_10	1547437.LL06_13215	1.606e-41	164.0	COG3412@1|root,COG3412@2|Bacteria,1RHM8@1224|Proteobacteria,2UASX@28211|Alphaproteobacteria,43PG3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Dihydroxyacetone kinase, phosphotransfer	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	EIIA-man
TLS3_k127_3614529_9	1121033.AUCF01000001_gene2261	5.138e-51	188.0	COG1461@1|root,COG1461@2|Bacteria,1MXIB@1224|Proteobacteria,2U5YZ@28211|Alphaproteobacteria,2JS82@204441|Rhodospirillales	204441|Rhodospirillales	S	Dak2	-	-	-	-	-	-	-	-	-	-	-	-	Dak2
TLS3_k127_3614529_2	935557.ATYB01000014_gene3782	1.087e-153	521.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TR7P@28211|Alphaproteobacteria,4BDD4@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_3614529_8	1297865.APJD01000006_gene4333	5.896e-76	266.0	COG2390@1|root,COG2390@2|Bacteria,1R558@1224|Proteobacteria,2U3PY@28211|Alphaproteobacteria,3JWUJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Putative sugar-binding domain	-	-	2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01059	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HTH_11,HTH_Crp_2,Sugar-bind
TLS3_k127_3614529_1	935557.ATYB01000014_gene3780	5.333e-165	533.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria,2TRFG@28211|Alphaproteobacteria,4BD88@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
TLS3_k127_3614529_7	744980.TRICHSKD4_2618	8.793e-90	305.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2U1NG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Aldolase	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
TLS3_k127_3614529_4	1079460.ATTQ01000001_gene5986	9.583e-134	436.0	COG1175@1|root,COG1175@2|Bacteria,1MUVG@1224|Proteobacteria,2U2IC@28211|Alphaproteobacteria,4BDNN@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_3614529_5	1281779.H009_21426	1.493e-131	441.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TU85@28211|Alphaproteobacteria,4B8P2@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10229	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	BPD_transp_1
TLS3_k127_3614529_0	1281779.H009_21431	1.607e-237	743.0	COG1653@1|root,COG1653@2|Bacteria,1R3Y9@1224|Proteobacteria,2VF3G@28211|Alphaproteobacteria,4BBX4@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_3614529_6	1297865.APJD01000006_gene4331	1.016e-115	381.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,3JW2H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_3614529_3	314231.FP2506_01853	9.574e-138	450.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS3_k127_3614529_11	1123229.AUBC01000001_gene1474	6.753e-21	100.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TYM2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	sugar phosphatases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,Hydrolase_6,Hydrolase_like
TLS3_k127_3626947_4	1530186.JQEY01000009_gene2948	2.172e-21	94.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0260 family	MA20_15575	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TLS3_k127_3626947_1	195105.CN97_07000	1.451e-118	393.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS3_k127_3626947_3	1121479.AUBS01000007_gene2199	2.253e-34	139.0	COG2020@1|root,COG2020@2|Bacteria,1RK3H@1224|Proteobacteria,2UC3K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS3_k127_3626947_2	1123247.AUIJ01000010_gene170	6.638e-59	228.0	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2U07P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	nahD	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS3_k127_3626947_0	195105.CN97_10995	7.266e-164	521.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS3_k127_3626947_5	1121946.AUAX01000015_gene6005	1.028e-15	91.0	COG1247@1|root,COG1247@2|Bacteria,2I3CR@201174|Actinobacteria,4DDTD@85008|Micromonosporales	201174|Actinobacteria	M	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_3631137_14	1207063.P24_05344	3.666e-27	128.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2JPI7@204441|Rhodospirillales	204441|Rhodospirillales	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
TLS3_k127_3631137_4	272943.RSP_2144	1.334e-160	523.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG2230 Cyclopropane fatty acid synthase and related methyltransferases	cfa	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0008825,GO:0009987,GO:0016740,GO:0016741,GO:0030258,GO:0032259,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS3_k127_3631137_10	570952.ATVH01000014_gene1877	1.016e-70	246.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2TUX0@28211|Alphaproteobacteria,2JRSA@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
TLS3_k127_3631137_7	1207063.P24_05329	4.104e-128	422.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2TQUH@28211|Alphaproteobacteria,2JQJY@204441|Rhodospirillales	204441|Rhodospirillales	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase
TLS3_k127_3631137_2	349102.Rsph17025_0815	1.69e-192	612.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,1FCFI@1060|Rhodobacter	28211|Alphaproteobacteria	H	DNA photolyase	phrB	GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS3_k127_3631137_11	690585.JNNU01000004_gene4144	3.944e-48	178.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria,4BEYV@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	bleomycin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_3631137_15	69395.JQLZ01000001_gene3369	2.987e-25	108.0	COG2261@1|root,COG2261@2|Bacteria,1N88H@1224|Proteobacteria,2UFV9@28211|Alphaproteobacteria,2KHFE@204458|Caulobacterales	204458|Caulobacterales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS3_k127_3631137_16	631454.N177_3576	4.979e-21	95.0	2DTSC@1|root,33MG7@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS3_k127_3631137_18	1040983.AXAE01000012_gene2013	2.475e-06	61.0	2DRQB@1|root,33CKR@2|Bacteria,1MZI3@1224|Proteobacteria,2UDVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3631137_0	1121271.AUCM01000005_gene642	1.172e-205	653.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA5	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS3_k127_3631137_8	1123360.thalar_00363	9.733e-124	426.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TQZR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	MA20_14685	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_3631137_5	384765.SIAM614_09798	7.33e-149	476.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	gsiC	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_3631137_12	1057002.KB905370_gene5860	2.651e-34	139.0	2DS4T@1|root,32USD@2|Bacteria,1RIFI@1224|Proteobacteria,2UBWM@28211|Alphaproteobacteria,4B97C@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3631137_6	1122132.AQYH01000007_gene2176	3.154e-146	477.0	COG1566@1|root,COG1566@2|Bacteria,1NAMI@1224|Proteobacteria,2TTW3@28211|Alphaproteobacteria,4BC3Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	Biotin-lipoyl like	yiaV	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2
TLS3_k127_3631137_9	1500304.JQKY01000007_gene3228	8.082e-122	396.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,4BA62@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS3_k127_3631137_13	1367847.JCM7686_1932	1.658e-27	128.0	COG4291@1|root,COG4291@2|Bacteria,1RKVD@1224|Proteobacteria,2VGBS@28211|Alphaproteobacteria,2PVWI@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1345)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
TLS3_k127_3631137_1	1449350.OCH239_21180	3.109e-202	663.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TU1J@28211|Alphaproteobacteria,4KNNC@93682|Roseivivax	28211|Alphaproteobacteria	E	ABC transporter substrate-binding protein	gsiB	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS3_k127_3631137_3	351016.RAZWK3B_10131	2.317e-187	596.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TUHU@28211|Alphaproteobacteria,2P1QI@2433|Roseobacter	28211|Alphaproteobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	dapE2	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_3631137_17	1469613.JT55_03545	1.166e-19	102.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VFZH@28211|Alphaproteobacteria,3FEMJ@34008|Rhodovulum	28211|Alphaproteobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,HTH_24,PUA_2
TLS3_k127_3648916_2	717785.HYPMC_0530	6.95e-06	52.0	2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3648916_1	1123360.thalar_00172	8.988e-24	106.0	COG4530@1|root,COG4530@2|Bacteria	2|Bacteria	P	PFAM conserved	MA20_24185	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
TLS3_k127_3648916_0	935840.JAEQ01000008_gene793	1.676e-151	490.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,43I1W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	TIGRFAM polyhydroxyalkanoate depolymerase, intracellular	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
TLS3_k127_3648916_3	1367847.JCM7686_1917	3.883e-05	53.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,2PV73@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function DUF45	MA20_23375	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
TLS3_k127_3672_1	1569209.BBPH01000117_gene3676	6.137e-89	295.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2TVZ3@28211|Alphaproteobacteria,2PW45@265|Paracoccus	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
TLS3_k127_3672_3	318586.Pden_5118	7.455e-63	234.0	COG4529@1|root,COG4529@2|Bacteria,1MU3U@1224|Proteobacteria,2TUBM@28211|Alphaproteobacteria,2PWU1@265|Paracoccus	28211|Alphaproteobacteria	S	FAD-NAD(P)-binding	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	NAD_binding_9
TLS3_k127_3672_2	1525715.IX54_05430	1.213e-73	256.0	COG4529@1|root,COG4529@2|Bacteria,1MU3U@1224|Proteobacteria,2TUBM@28211|Alphaproteobacteria,2PWU1@265|Paracoccus	28211|Alphaproteobacteria	S	FAD-NAD(P)-binding	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	NAD_binding_9
TLS3_k127_3672_0	1367847.JCM7686_1202	3.637e-148	484.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2TVZ3@28211|Alphaproteobacteria,2PUZ9@265|Paracoccus	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran
TLS3_k127_3672_4	759362.KVU_1105	4.023e-08	57.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2TVZ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran
TLS3_k127_3674805_1	570967.JMLV01000006_gene199	2.907e-83	284.0	COG3016@1|root,COG3016@2|Bacteria,1NXYQ@1224|Proteobacteria,2U0QY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Iron-regulated protein	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
TLS3_k127_3674805_0	1041159.AZUW01000003_gene4867	4.954e-156	501.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,4B7D7@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glycine cleavage system T protein	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS3_k127_3674805_2	375451.RD1_1223	9.813e-51	183.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,2P3FV@2433|Roseobacter	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
TLS3_k127_3689479_2	1317118.ATO8_03646	8.008e-41	154.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,4KKI5@93682|Roseivivax	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS3_k127_3689479_1	1123360.thalar_00322	1.44e-61	230.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2TUA2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	bacC	-	1.1.1.159	ko:K00076	ko00121,map00121	-	-	-	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS3_k127_3689479_0	367336.OM2255_08170	1.74e-98	336.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_20925	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
TLS3_k127_3689479_3	1469613.JT55_09600	1.061e-40	167.0	COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,3FD9P@34008|Rhodovulum	28211|Alphaproteobacteria	J	Ribonuclease T2 family	rns	-	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
TLS3_k127_3707624_1	1317124.DW2_06663	4.399e-41	159.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,2XKR6@285107|Thioclava	28211|Alphaproteobacteria	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS3_k127_3707624_0	1353537.TP2_03705	1.615e-247	775.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2XN02@285107|Thioclava	28211|Alphaproteobacteria	S	Putative modulator of DNA gyrase	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_3715857_4	1123229.AUBC01000012_gene2685	6.379e-65	229.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2TS85@28211|Alphaproteobacteria,3JXET@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative sugar-binding N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
TLS3_k127_3715857_3	1123229.AUBC01000012_gene2688	7.009e-80	277.0	COG2186@1|root,COG2186@2|Bacteria,1MUP9@1224|Proteobacteria,2TV1R@28211|Alphaproteobacteria,3K6GG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
TLS3_k127_3715857_2	290400.Jann_3061	8.865e-97	344.0	2CB42@1|root,2Z7Y3@2|Bacteria,1PK1X@1224|Proteobacteria,2TVBX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3715857_1	1123229.AUBC01000012_gene2687	1.145e-126	430.0	COG0673@1|root,COG0673@2|Bacteria,1MW74@1224|Proteobacteria,2TSFH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_3715857_0	1123229.AUBC01000012_gene2684	1.413e-129	427.0	COG0059@1|root,COG0059@2|Bacteria,1R05A@1224|Proteobacteria,2TYJD@28211|Alphaproteobacteria,3K2N1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Phosphogluconate dehydrogenase (decarboxylating) C-term	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored,IlvN,PGDH_C
TLS3_k127_3715857_5	1123229.AUBC01000012_gene2684	2.016e-28	114.0	COG0059@1|root,COG0059@2|Bacteria,1R05A@1224|Proteobacteria,2TYJD@28211|Alphaproteobacteria,3K2N1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Phosphogluconate dehydrogenase (decarboxylating) C-term	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored,IlvN,PGDH_C
TLS3_k127_3724550_2	388401.RB2150_05553	9.842e-38	143.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,3ZGH9@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
TLS3_k127_3724550_0	935840.JAEQ01000005_gene1208	1.667e-263	818.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,43H1D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS3_k127_3724550_1	716928.AJQT01000043_gene3159	9.821e-43	162.0	2C846@1|root,32GGG@2|Bacteria,1RIHT@1224|Proteobacteria,2U9Y6@28211|Alphaproteobacteria,4BKZC@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
TLS3_k127_3726017_6	1123247.AUIJ01000009_gene3038	3.719e-69	249.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Pyruvate phosphate dikinase	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_3726017_3	176299.Atu4647	2.017e-126	417.0	COG2113@1|root,COG2113@2|Bacteria,1MVIG@1224|Proteobacteria,2TRV8@28211|Alphaproteobacteria,4B730@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC-type proline glycine betaine transport systems, periplasmic components	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS3_k127_3726017_1	1125973.JNLC01000015_gene3390	7.61e-237	742.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,3JW9D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	betC	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Choline_sulf_C,DUF4976,Sulfatase
TLS3_k127_3726017_0	1294273.roselon_00032	2.024e-244	766.0	COG5598@1|root,COG5598@2|Bacteria,1MX73@1224|Proteobacteria,2TS1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
TLS3_k127_3726017_4	1502851.FG93_00327	5.728e-125	406.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,3JSFP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	MA20_05720	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS3_k127_3726017_2	1101192.KB910516_gene4014	7.936e-159	533.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2TS9Q@28211|Alphaproteobacteria,1JQWF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
TLS3_k127_3726017_7	1500257.JQNM01000002_gene4683	1.087e-51	192.0	COG4101@1|root,COG4101@2|Bacteria,1RIFZ@1224|Proteobacteria,2UER9@28211|Alphaproteobacteria,4BDZP@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_3726017_9	351016.RAZWK3B_20206	2.216e-33	134.0	2D78S@1|root,32TNJ@2|Bacteria,1N0VB@1224|Proteobacteria,2UCAT@28211|Alphaproteobacteria,2P3K5@2433|Roseobacter	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4864)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4864
TLS3_k127_3726017_8	644107.SL1157_0544	6.266e-38	149.0	COG5434@1|root,COG5434@2|Bacteria,1MVBW@1224|Proteobacteria,2TVNM@28211|Alphaproteobacteria,4NADN@97050|Ruegeria	28211|Alphaproteobacteria	M	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
TLS3_k127_3726017_5	1082933.MEA186_35259	3.036e-110	374.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,43IGF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,EAL,GGDEF
TLS3_k127_3733830_4	999547.KI421500_gene136	7.46e-131	435.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U0RN@28211|Alphaproteobacteria,280H8@191028|Leisingera	28211|Alphaproteobacteria	Q	Animal haem peroxidase	-	-	1.11.1.7	ko:K19511	-	-	-	-	ko00000,ko01000	-	-	-	An_peroxidase,HemolysinCabind
TLS3_k127_3733830_9	497964.CfE428DRAFT_2018	1.918e-48	177.0	COG3651@1|root,COG3651@2|Bacteria,46VSR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2237
TLS3_k127_3733830_3	349102.Rsph17025_3020	1.363e-146	476.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2TSVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
TLS3_k127_3733830_1	316056.RPC_0079	4.129e-241	780.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2TSPH@28211|Alphaproteobacteria,3JTE5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	attG	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_3733830_8	272943.RSP_1542	4.661e-77	286.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2TSNF@28211|Alphaproteobacteria,1FD3X@1060|Rhodobacter	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	MA20_22875	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_3733830_0	1381123.AYOD01000003_gene1912	0.0	1248.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,43ITV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
TLS3_k127_3733830_10	272943.RSP_3327	1.641e-44	173.0	COG0705@1|root,COG0705@2|Bacteria,1RCNV@1224|Proteobacteria,2U6Q7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
TLS3_k127_3733830_2	1192868.CAIU01000008_gene1042	1.619e-202	641.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria,43ICQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	PFAM phospholipase D	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
TLS3_k127_3733830_11	52598.EE36_12848	2.156e-21	102.0	COG4222@1|root,COG4222@2|Bacteria,1N0B0@1224|Proteobacteria,2TT18@28211|Alphaproteobacteria,3ZY9A@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Esterase-like activity of phytase	MA20_03555	-	-	-	-	-	-	-	-	-	-	-	Phytase-like
TLS3_k127_3733830_6	626418.bglu_1g18390	1.153e-96	323.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHZJ@28216|Betaproteobacteria,1K3N9@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N
TLS3_k127_3733830_5	1410620.SHLA_1c001980	3.423e-104	347.0	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2TVXU@28211|Alphaproteobacteria,4B73V@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	fpr	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
TLS3_k127_3733830_7	349102.Rsph17025_1987	1.932e-90	307.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,1FAPC@1060|Rhodobacter	28211|Alphaproteobacteria	JKL	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K03732,ko:K11927	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS3_k127_3744139_1	1028800.RG540_CH08240	8.748e-40	150.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,2UC19@28211|Alphaproteobacteria,4BFUB@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS3_k127_3744139_0	1121271.AUCM01000012_gene2997	1.98e-216	689.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase)	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
TLS3_k127_3753839_2	1123360.thalar_03047	5.827e-08	63.0	COG3118@1|root,COG3118@2|Bacteria,1R8CU@1224|Proteobacteria,2U2AN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	belongs to the thioredoxin family	flaA	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3753839_0	388739.RSK20926_08887	1.287e-135	437.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,2P21N@2433|Roseobacter	28211|Alphaproteobacteria	N	COG1291 Flagellar motor component	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS3_k127_3753839_1	571166.KI421509_gene2754	4.513e-30	126.0	COG3334@1|root,COG3334@2|Bacteria,1RKF6@1224|Proteobacteria	1224|Proteobacteria	S	PFAM MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	MgtE_N
TLS3_k127_3753839_3	1472418.BBJC01000001_gene453	6.961e-08	61.0	2CM6A@1|root,32SDT@2|Bacteria,1N0P3@1224|Proteobacteria,2UCD1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3754570_1	1353537.TP2_07160	4.77e-162	515.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2XMB6@285107|Thioclava	28211|Alphaproteobacteria	C	Catalyzes the formation of succinate from succinate semialdehyde	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_3754570_0	314264.ROS217_06765	1.974e-173	557.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,46QGE@74030|Roseovarius	28211|Alphaproteobacteria	H	Iron-sulfur cluster-binding domain	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,PqqD,Radical_SAM,SPASM
TLS3_k127_3754570_3	1530186.JQEY01000005_gene3519	9.941e-27	122.0	COG0535@1|root,COG0535@2|Bacteria,1N7TR@1224|Proteobacteria,2UFAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	coenzyme PQQ synthesis	pqqD	-	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
TLS3_k127_3754570_2	314265.R2601_04903	1.698e-103	338.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2TSQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06136,ko:K06137,ko:K06138	-	-	-	-	ko00000,ko01000	-	-	-	PqqD,TENA_THI-4
TLS3_k127_3770605_1	1131814.JAFO01000001_gene3885	1.072e-40	164.0	COG2303@1|root,COG2303@2|Bacteria,1MXUT@1224|Proteobacteria	1224|Proteobacteria	E	(GMC) oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,DUF1080,FAD_binding_2,FAD_binding_3,GMC_oxred_C,GMC_oxred_N
TLS3_k127_3770605_0	1056820.KB900685_gene2798	4.142e-96	326.0	COG1215@1|root,COG1215@2|Bacteria,1R4ZM@1224|Proteobacteria,1S1EG@1236|Gammaproteobacteria,2PPHX@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_3770605_2	1248916.ANFY01000005_gene2785	2.151e-32	136.0	COG1216@1|root,COG1216@2|Bacteria,1R5GW@1224|Proteobacteria,2TTEN@28211|Alphaproteobacteria,2K3YZ@204457|Sphingomonadales	204457|Sphingomonadales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS3_k127_3784593_1	716928.AJQT01000051_gene1414	1.648e-243	758.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2TRUJ@28211|Alphaproteobacteria,4B8IE@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Phosphoglucomutase	pgm	GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005982,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009266,GO:0009409,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009581,GO:0009582,GO:0009590,GO:0009605,GO:0009628,GO:0009629,GO:0009941,GO:0009987,GO:0010319,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019252,GO:0019318,GO:0019320,GO:0019388,GO:0031967,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046365,GO:0048046,GO:0050896,GO:0051606,GO:0055114,GO:0071704,GO:1901575,GO:1901576	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_3784593_0	1040986.ATYO01000001_gene1945	8.152e-245	788.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,43J5W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196	ko:K02438	ko00500,ko01100,map00500,map01100	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS3_k127_3784593_2	1525715.IX54_15635	9.604e-145	475.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2TRU1@28211|Alphaproteobacteria,2PVEZ@265|Paracoccus	28211|Alphaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoG	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
TLS3_k127_3784593_3	1449351.RISW2_10725	2.783e-118	399.0	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,2TQU8@28211|Alphaproteobacteria,4KMHS@93682|Roseivivax	28211|Alphaproteobacteria	M	Glycosyl transferase family 21	opgH	GO:0005575,GO:0016020	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glyco_trans_2_3
TLS3_k127_3787146_0	1294273.roselon_03141	1.297e-238	746.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS3_k127_3787146_1	1417296.U879_15145	5.118e-66	229.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2TU3N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS3_k127_3804109_0	412597.AEPN01000001_gene2929	1.711e-161	521.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,2PVNV@265|Paracoccus	28211|Alphaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
TLS3_k127_3804109_7	38833.XP_003057314.1	0.0006819	50.0	KOG3648@1|root,KOG3648@2759|Eukaryota,37YRY@33090|Viridiplantae,34JQK@3041|Chlorophyta	3041|Chlorophyta	U	Cysteine rich repeat	-	-	-	ko:K06816	ko04514,map04514	-	-	-	ko00000,ko00001,ko04516	-	-	-	Cys_rich_FGFR
TLS3_k127_3804109_3	398580.Dshi_3429	2.028e-83	287.0	COG1896@1|root,COG1896@2|Bacteria,1RACF@1224|Proteobacteria,2TUK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolases of HD superfamily	MA20_42120	-	-	ko:K06952	-	-	-	-	ko00000	-	-	-	HD,HD_3
TLS3_k127_3804109_1	1188256.BASI01000001_gene1000	4.707e-103	344.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,3FCYV@34008|Rhodovulum	28211|Alphaproteobacteria	O	Tetratricopeptide repeat	trxA2	-	-	ko:K03671,ko:K05838	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS3_k127_3804109_2	1469613.JT55_14405	1.076e-92	309.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,3FD5S@34008|Rhodovulum	28211|Alphaproteobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TLS3_k127_3804109_6	272942.RCAP_rcc03332	2.188e-17	96.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2UF4N@28211|Alphaproteobacteria,1FC5M@1060|Rhodobacter	28211|Alphaproteobacteria	S	Belongs to the UPF0434 family	MA20_24965	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
TLS3_k127_3804109_4	1449351.RISW2_19275	1.067e-48	182.0	COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria,4KMGJ@93682|Roseivivax	28211|Alphaproteobacteria	S	Stringent starvation protein B	MA20_02250	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
TLS3_k127_3804109_5	1054213.HMPREF9946_00141	1.988e-24	106.0	COG3247@1|root,COG3247@2|Bacteria,1N5EQ@1224|Proteobacteria,2TRDZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	response to pH	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3807426_3	272943.RSP_0306	7.531e-110	364.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS3_k127_3807426_1	1469613.JT55_11295	0.0	1009.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2TSXP@28211|Alphaproteobacteria,3FCGR@34008|Rhodovulum	28211|Alphaproteobacteria	E	Urease alpha-subunit, N-terminal domain	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
TLS3_k127_3807426_4	991905.SL003B_0765	5.325e-102	336.0	COG3791@1|root,COG3791@2|Bacteria,1MX4A@1224|Proteobacteria,2TSAN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione	gfa	-	4.4.1.22	ko:K03396	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R06982	RC00069,RC01707	ko00000,ko00001,ko01000	-	-	-	GFA
TLS3_k127_3807426_8	1188256.BASI01000002_gene3479	1.155e-47	175.0	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2TVBW@28211|Alphaproteobacteria,3FD7Q@34008|Rhodovulum	28211|Alphaproteobacteria	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
TLS3_k127_3807426_7	272943.RSP_0303	3.417e-60	216.0	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2TRVW@28211|Alphaproteobacteria,1FBV5@1060|Rhodobacter	28211|Alphaproteobacteria	J	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
TLS3_k127_3807426_5	595536.ADVE02000002_gene4192	4.394e-99	335.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2TQMU@28211|Alphaproteobacteria,36XT9@31993|Methylocystaceae	28211|Alphaproteobacteria	KO	CobW/HypB/UreG, nucleotide-binding domain	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
TLS3_k127_3807426_2	1231392.OCGS_0828	3.228e-186	589.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS3_k127_3807426_6	388401.RB2150_16377	3.034e-69	242.0	COG3803@1|root,COG3803@2|Bacteria,1RIPA@1224|Proteobacteria,2UA7E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
TLS3_k127_3807426_0	195105.CN97_06045	0.0	1017.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
TLS3_k127_3807426_9	1317124.DW2_10764	8.05e-16	80.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,2XMNT@285107|Thioclava	28211|Alphaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS3_k127_3819592_0	1123501.KB902289_gene1622	3.559e-157	507.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
TLS3_k127_3819592_1	631454.N177_1022	1.032e-114	376.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,1JNGG@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS3_k127_3856280_3	999547.KI421500_gene2105	2.556e-88	297.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,2TVI6@28211|Alphaproteobacteria,27ZPB@191028|Leisingera	28211|Alphaproteobacteria	M	Glycosyl hydrolases family 25	lyc	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
TLS3_k127_3856280_1	272943.RSP_3229	8.589e-156	514.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,1FAYJ@1060|Rhodobacter	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	mltB	-	-	ko:K00786,ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
TLS3_k127_3856280_5	1472418.BBJC01000005_gene2376	2.921e-23	113.0	COG1226@1|root,COG1226@2|Bacteria,1NH49@1224|Proteobacteria,2UENB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Potassium channel protein	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS3_k127_3856280_2	991905.SL003B_3482	1.038e-101	336.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,4BPCH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS3_k127_3856280_0	1156935.QWE_12853	7.4e-212	676.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria,4BBF4@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_17,Fer4_8,LUD_dom
TLS3_k127_3856280_4	1120956.JHZK01000022_gene1548	2.968e-39	168.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2U5II@28211|Alphaproteobacteria,1JNWG@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TLS3_k127_3864305_3	1402135.SUH3_12255	1.018e-32	135.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria,3ZW2D@60136|Sulfitobacter	28211|Alphaproteobacteria	P	SBF-like CPA transporter family (DUF4137)	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
TLS3_k127_3864305_2	1449350.OCH239_15285	2.578e-102	340.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,4KNGK@93682|Roseivivax	28211|Alphaproteobacteria	K	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,LMWPc
TLS3_k127_3864305_1	1105367.CG50_16005	1.754e-140	452.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2TS7I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	ko:K21826	-	-	-	-	ko00000,ko03000	-	-	-	DJ-1_PfpI,HTH_18
TLS3_k127_3864305_0	367336.OM2255_06685	2.344e-219	688.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
TLS3_k127_3891011_0	1381123.AYOD01000002_gene543	3.659e-294	907.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,43IR6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_3891011_4	1116369.KB890024_gene2368	9.535e-73	249.0	2BXMA@1|root,2ZBQ1@2|Bacteria,1MXZ1@1224|Proteobacteria,2TUF6@28211|Alphaproteobacteria,43JK6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3891011_5	1231190.NA8A_14951	6.147e-60	218.0	COG0346@1|root,COG0346@2|Bacteria,1RI06@1224|Proteobacteria,2U77N@28211|Alphaproteobacteria,43K0K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Lactoylglutathione lyase	lguL	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
TLS3_k127_3891011_8	1231190.NA8A_14956	4.857e-32	136.0	COG4321@1|root,COG4321@2|Bacteria,1MZP2@1224|Proteobacteria,2UBZU@28211|Alphaproteobacteria,43KGN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	RHH_4
TLS3_k127_3891011_1	398580.Dshi_0728	2.088e-218	703.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2TRIR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (Chain L) multisubunit Na H antiporter, MnhA subunit	mrpA	GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,Proton_antipo_M,Proton_antipo_N
TLS3_k127_3891011_7	398580.Dshi_0729	5.013e-34	152.0	COG2111@1|root,COG2111@2|Bacteria,1REGG@1224|Proteobacteria,2UB7J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Subunit B of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
TLS3_k127_3891011_6	398580.Dshi_0730	2.475e-39	149.0	COG1006@1|root,COG1006@2|Bacteria,1RH8H@1224|Proteobacteria,2UA52@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Multisubunit Na H antiporter, MnhC subunit	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS3_k127_3891011_2	398580.Dshi_0731	2.524e-165	547.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS3_k127_3891011_9	398580.Dshi_0732	1.225e-25	123.0	COG1863@1|root,COG1863@2|Bacteria,1RB2I@1224|Proteobacteria,2U5QR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Multisubunit Na H antiporter, MnhE subunit	mnhE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS3_k127_3891011_11	266809.PM03_02405	2.642e-10	66.0	COG2212@1|root,COG2212@2|Bacteria,1N7BC@1224|Proteobacteria,2UF5W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Multisubunit Na H antiporter, MnhF subunit	mnhF	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
TLS3_k127_3891011_10	290400.Jann_3689	1.728e-24	108.0	COG1320@1|root,COG1320@2|Bacteria,1MZ6Z@1224|Proteobacteria,2UDZK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na H antiporter	mrpG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS3_k127_3891011_3	272943.RSP_6056	1.459e-128	419.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2TS4G@28211|Alphaproteobacteria,1FB98@1060|Rhodobacter	28211|Alphaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
TLS3_k127_3901386_5	1337093.MBE-LCI_2941	7.62e-82	282.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2TUX7@28211|Alphaproteobacteria,2P9KM@245186|Loktanella	28211|Alphaproteobacteria	M	Transglycosylase SLT domain	MA20_36170	-	-	-	-	-	-	-	-	-	-	-	SLT,SPOR
TLS3_k127_3901386_1	426117.M446_5727	2.021e-167	536.0	COG3546@1|root,COG3546@2|Bacteria,1R6EN@1224|Proteobacteria,2TRQJ@28211|Alphaproteobacteria,1JQTU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM manganese containing catalase	-	-	-	-	-	-	-	-	-	-	-	-	Mn_catalase
TLS3_k127_3901386_7	765912.Thimo_0178	5.809e-22	101.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1WYXG@135613|Chromatiales	135613|Chromatiales	P	Divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS3_k127_3901386_2	1500257.JQNM01000002_gene4260	2.404e-146	467.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,4B9FB@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	hpcE	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
TLS3_k127_3901386_4	1320556.AVBP01000020_gene233	5.167e-109	362.0	COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria,43GVD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	with different specificities (related to short-chain alcohol	MA20_27190	-	1.1.1.30	ko:K00019,ko:K18335	ko00051,ko00072,ko00650,ko01100,ko01120,map00051,map00072,map00650,map01100,map01120	M00088	R01361,R10690	RC00089,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
TLS3_k127_3901386_0	314232.SKA53_02596	2.261e-236	749.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2P8B7@245186|Loktanella	28211|Alphaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
TLS3_k127_3901386_3	272942.RCAP_rcc01574	1.999e-112	373.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,1FCD7@1060|Rhodobacter	28211|Alphaproteobacteria	H	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS3_k127_3901386_6	1123247.AUIJ01000027_gene663	1.036e-73	269.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	mlaE	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
TLS3_k127_3910963_3	318586.Pden_1238	6.966e-63	227.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2TQZ1@28211|Alphaproteobacteria,2PVI2@265|Paracoccus	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
TLS3_k127_3910963_5	391613.RTM1035_10860	1.715e-49	193.0	COG2128@1|root,COG2128@2|Bacteria,1RD2I@1224|Proteobacteria,2U7MW@28211|Alphaproteobacteria,46QSI@74030|Roseovarius	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS3_k127_3910963_2	366394.Smed_2035	1.034e-118	389.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,2TSIG@28211|Alphaproteobacteria,4BEGY@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase,TAT_signal
TLS3_k127_3910963_0	398580.Dshi_1469	1.06e-187	594.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_3910963_6	1121933.AUHH01000001_gene2161	2.275e-22	107.0	2CF2I@1|root,33GH4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3910963_4	243233.MCA1625	6.97e-53	205.0	COG4636@1|root,COG4636@2|Bacteria,1R58B@1224|Proteobacteria,1RSKS@1236|Gammaproteobacteria,1XERW@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_3910963_1	272942.RCAP_rcc02295	2.258e-126	409.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,1FAU6@1060|Rhodobacter	28211|Alphaproteobacteria	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS3_k127_3911481_4	314265.R2601_10409	2.607e-15	86.0	COG5568@1|root,COG5568@2|Bacteria,1N6UW@1224|Proteobacteria,2UF8P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1150)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1150
TLS3_k127_3911481_0	1123501.KB902315_gene3418	4.087e-66	229.0	COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspH	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
TLS3_k127_3911481_3	266809.PM03_01620	5.022e-19	89.0	COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	small protein containing a coiled-coil domain	MA20_03740	-	-	-	-	-	-	-	-	-	-	-	DUF465
TLS3_k127_3911481_1	1123367.C666_12305	5.432e-62	218.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,2KW4U@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
TLS3_k127_3911481_2	1449351.RISW2_18075	2.635e-51	189.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,4KMAB@93682|Roseivivax	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS3_k127_3924779_1	1208323.B30_15186	5.91e-29	124.0	COG2197@1|root,COG2197@2|Bacteria,1RA3V@1224|Proteobacteria,2U0I0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	kdpE	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_3924779_3	243365.CV_0195	0.0001627	48.0	2EKBB@1|root,33E1Q@2|Bacteria,1NJ3D@1224|Proteobacteria,2VXMB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3924779_0	1122929.KB908215_gene553	2.225e-111	376.0	COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,2TRCE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	-	5.5.1.2	ko:K01857	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03307	RC00902	ko00000,ko00001,ko01000	-	-	-	ADSL_C,Lyase_1
TLS3_k127_3924779_2	1123247.AUIJ01000012_gene904	4.539e-16	78.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TRG7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
TLS3_k127_3928947_1	1288298.rosmuc_02495	2.12e-107	355.0	COG3239@1|root,COG3239@2|Bacteria,1MXA8@1224|Proteobacteria,2TUQG@28211|Alphaproteobacteria,46QCS@74030|Roseovarius	28211|Alphaproteobacteria	I	COG3239 Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
TLS3_k127_3928947_3	290400.Jann_3514	7.545e-58	213.0	COG3221@1|root,COG3221@2|Bacteria,1R6YE@1224|Proteobacteria,2U6QH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
TLS3_k127_3928947_5	272943.RSP_2388	1.13e-36	147.0	COG0494@1|root,COG0494@2|Bacteria,1MZ5D@1224|Proteobacteria,2UBX9@28211|Alphaproteobacteria,1FC46@1060|Rhodobacter	28211|Alphaproteobacteria	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_3928947_2	1231392.OCGS_1950	2.448e-89	304.0	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2TUQ5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Dmso reductase anchor subunit	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
TLS3_k127_3928947_0	1525715.IX54_14560	0.0	1506.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2PUSF@265|Paracoccus	28211|Alphaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
TLS3_k127_3928947_4	1121271.AUCM01000008_gene3148	3.307e-52	186.0	COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,2TU53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	MA20_04555	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08990	-	-	-	-	ko00000	-	-	-	DUF697
TLS3_k127_3931221_0	1297569.MESS2_730015	1.097e-244	764.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC transporter	-	-	-	ko:K17210	ko02010,map02010	M00592	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.21	-	-	ABC_tran
TLS3_k127_3931221_1	1297569.MESS2_730016	4.679e-155	514.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2U0D6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17209	ko02010,map02010	M00212,M00592	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21	-	-	BPD_transp_2
TLS3_k127_3931221_2	1381123.AYOD01000015_gene2603	1.623e-118	386.0	COG1177@1|root,COG1177@2|Bacteria,1NGDC@1224|Proteobacteria,2U2G2@28211|Alphaproteobacteria,43HUT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	cysT	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS3_k127_3931221_3	1156935.QWE_03453	1.691e-108	368.0	COG1176@1|root,COG1176@2|Bacteria,1R47U@1224|Proteobacteria,2U0UW@28211|Alphaproteobacteria,4BAVQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS3_k127_3931221_4	1211115.ALIQ01000184_gene4172	3.829e-72	248.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3NB6W@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	TOBE domain	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS3_k127_3938507_5	1096546.WYO_1956	3.088e-17	83.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS3_k127_3938507_4	266779.Meso_2114	1.378e-20	101.0	COG3306@1|root,COG3306@2|Bacteria,1N5KB@1224|Proteobacteria,2UD6J@28211|Alphaproteobacteria,43KZF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	COG3306 Glycosyltransferase involved in LPS biosynthesis	-	-	-	ko:K07270	-	-	-	-	ko00000	-	GT25	-	Glyco_transf_25
TLS3_k127_3938507_2	1122962.AULH01000016_gene221	1.778e-71	257.0	28H5T@1|root,2Z7IB@2|Bacteria,1N7V9@1224|Proteobacteria,2TTZQ@28211|Alphaproteobacteria,3712F@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3938507_0	371731.Rsw2DRAFT_2580	0.0	1151.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,1FAXW@1060|Rhodobacter	28211|Alphaproteobacteria	C	Phosphate acetyl butaryl transferase	dme	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
TLS3_k127_3938507_3	1144343.PMI41_03467	9.984e-49	184.0	COG5646@1|root,COG5646@2|Bacteria,1N60V@1224|Proteobacteria,2UMYY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_3938507_1	314256.OG2516_13444	1.894e-319	988.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,2PCA6@252301|Oceanicola	28211|Alphaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.1,6.2.1.17	ko:K01895,ko:K01908	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS3_k127_3952198_0	252305.OB2597_14921	2.741e-226	708.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,2PCYN@252301|Oceanicola	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
TLS3_k127_3952198_1	743836.AYNA01000147_gene553	2.569e-116	384.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2U5X1@28211|Alphaproteobacteria,36YNY@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Carboxylesterase family	-	-	3.1.1.83	ko:K01066,ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
TLS3_k127_3953519_1	1509405.GV67_02370	9.614e-131	424.0	COG2390@1|root,COG2390@2|Bacteria,1MWHQ@1224|Proteobacteria,2TSIT@28211|Alphaproteobacteria,4B82Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	smoC	-	-	-	-	-	-	-	-	-	-	-	MarR_2,Sugar-bind
TLS3_k127_3953519_0	1547437.LL06_13185	1.877e-233	728.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2TSYG@28211|Alphaproteobacteria,43J3X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	smoE	-	-	ko:K02027,ko:K10227	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	SBP_bac_1
TLS3_k127_3961053_5	1188256.BASI01000002_gene3160	1.079e-30	132.0	COG3591@1|root,COG3591@2|Bacteria,1MXUN@1224|Proteobacteria,2TT3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG3591 V8-like Glu-specific endopeptidase	-	-	-	ko:K04775	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Trypsin,Trypsin_2
TLS3_k127_3961053_4	388399.SSE37_18155	2.597e-55	199.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
TLS3_k127_3961053_1	991905.SL003B_1516	3.874e-135	443.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,4BTE3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_3961053_2	1188256.BASI01000001_gene698	3.012e-114	376.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,3FD76@34008|Rhodovulum	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_3961053_0	1504981.KO116_1087	2.789e-208	654.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS3_k127_3961053_6	398580.Dshi_1873	1.047e-27	115.0	COG2863@1|root,COG2863@2|Bacteria,1NGKI@1224|Proteobacteria	1224|Proteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS3_k127_3961053_3	644107.SL1157_1459	5.576e-58	208.0	COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,2TRJD@28211|Alphaproteobacteria,4NB0C@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS3_k127_3961053_11	1449346.JQMO01000003_gene2423	5.356e-07	55.0	COG3899@1|root,COG3899@2|Bacteria,2HEUH@201174|Actinobacteria,2M5KT@2063|Kitasatospora	201174|Actinobacteria	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS3_k127_3961053_10	935840.JAEQ01000002_gene3438	6.738e-08	65.0	COG0457@1|root,COG0457@2|Bacteria,1NKZ8@1224|Proteobacteria,2URA3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3961053_7	935840.JAEQ01000002_gene3438	3.403e-19	96.0	COG0457@1|root,COG0457@2|Bacteria,1NKZ8@1224|Proteobacteria,2URA3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3961053_9	1038862.KB893847_gene5947	1.456e-10	70.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2U37P@28211|Alphaproteobacteria,3JXAU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8,Trans_reg_C
TLS3_k127_3961053_8	1123269.NX02_00855	6.451e-19	90.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_3968080_4	1123229.AUBC01000001_gene1449	1.359e-25	114.0	COG1404@1|root,COG1404@2|Bacteria,1PH66@1224|Proteobacteria,2V8WN@28211|Alphaproteobacteria,3K5IK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS3_k127_3968080_0	1415756.JQMY01000001_gene3125	0.0	1516.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,2PCUQ@252301|Oceanicola	28211|Alphaproteobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS3_k127_3968080_3	1231185.BAMP01000034_gene514	3.52e-43	160.0	COG2351@1|root,COG2351@2|Bacteria,1RH84@1224|Proteobacteria,2U9IT@28211|Alphaproteobacteria,43K94@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
TLS3_k127_3968080_1	375451.RD1_4068	8.408e-167	542.0	COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,2TR3Q@28211|Alphaproteobacteria,2P22E@2433|Roseobacter	28211|Alphaproteobacteria	C	COG4630 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
TLS3_k127_3968080_2	272942.RCAP_rcc00791	7.599e-112	373.0	COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,2TTAB@28211|Alphaproteobacteria,1FBE3@1060|Rhodobacter	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_3983954_0	384765.SIAM614_14295	1.126e-174	555.0	COG4425@1|root,COG4425@2|Bacteria,1MXSU@1224|Proteobacteria,2TV9M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
TLS3_k127_3983954_2	1185766.DL1_00200	2.452e-34	151.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2U5K0@28211|Alphaproteobacteria,2XMBU@285107|Thioclava	28211|Alphaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
TLS3_k127_3983954_1	1121271.AUCM01000003_gene1727	1.277e-136	451.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2TS3F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS3_k127_3983954_3	1123247.AUIJ01000002_gene2262	3.448e-16	83.0	298HD@1|root,2ZVNE@2|Bacteria,1RDBR@1224|Proteobacteria,2U79Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Component of SufBCD complex	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3986700_2	441620.Mpop_4835	1.772e-97	328.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,1JSGB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	FL	PFAM helix-turn-helix- domain containing protein AraC type	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
TLS3_k127_3986700_1	1121028.ARQE01000004_gene1558	2.599e-126	417.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria,2PKQA@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Domain of unknown function DUF21	tlyC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_3986700_0	1122212.AULO01000010_gene299	2.263e-211	664.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XHXR@135619|Oceanospirillales	135619|Oceanospirillales	Q	TRAP-type mannitol chloroaromatic compound transport system, large permease component	gtrB	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS3_k127_3986700_3	266779.Meso_2812	5.831e-66	229.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U75U@28211|Alphaproteobacteria,43J4V@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS3_k127_4008115_5	1304877.KI519399_gene2067	4.778e-35	136.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,3JUNP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
TLS3_k127_4008115_0	1469613.JT55_08165	9.042e-68	238.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,3FD8T@34008|Rhodovulum	28211|Alphaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS3_k127_4008115_1	1530186.JQEY01000013_gene65	7.138e-50	190.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2U94X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS3_k127_4008115_4	935848.JAEN01000002_gene839	3.349e-40	161.0	COG1605@1|root,COG1605@2|Bacteria,1MZTQ@1224|Proteobacteria,2UCMC@28211|Alphaproteobacteria,2PXE2@265|Paracoccus	28211|Alphaproteobacteria	E	Chorismate mutase type II	tyrA	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
TLS3_k127_4008115_2	1121271.AUCM01000006_gene400	9.747e-49	188.0	COG1670@1|root,COG1670@2|Bacteria,1PY0X@1224|Proteobacteria,2VEXD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_4008115_3	1417296.U879_07765	2.681e-46	175.0	COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,2U851@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS3_k127_4008115_6	1156935.QWE_08241	2.557e-06	51.0	COG1670@1|root,COG1670@2|Bacteria,1PY0X@1224|Proteobacteria,2VEXD@28211|Alphaproteobacteria,4BMIT@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_4025300_4	1231392.OCGS_0787	6.776e-40	158.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2TUNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	DM	COG0739 Membrane proteins related to metalloendopeptidases	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
TLS3_k127_4025300_2	388739.RSK20926_16472	1.056e-89	299.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,2P1ZG@2433|Roseobacter	28211|Alphaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS3_k127_4025300_1	1122180.Lokhon_02973	6.963e-93	312.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,2P7YT@245186|Loktanella	28211|Alphaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
TLS3_k127_4025300_5	759362.KVU_2576	1.919e-20	102.0	COG5454@1|root,COG5454@2|Bacteria,1N778@1224|Proteobacteria,2UBS2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1467
TLS3_k127_4025300_3	501479.ACNW01000096_gene933	7.825e-74	250.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS3_k127_4025300_6	1208323.B30_12497	3.861e-12	80.0	COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2UJFJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Cytochrome oxidase maturation protein	fixS	-	-	-	-	-	-	-	-	-	-	-	FixS
TLS3_k127_4025300_0	1188256.BASI01000001_gene1279	2.277e-219	700.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3FCJ7@34008|Rhodovulum	28211|Alphaproteobacteria	P	P-type ATPase'	fixI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_4037918_2	395965.Msil_3452	2.751e-108	362.0	COG0387@1|root,COG0387@2|Bacteria,1MWD8@1224|Proteobacteria,2TS6S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium calcium exchanger membrane	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
TLS3_k127_4037918_5	1449351.RISW2_09145	2.03e-43	165.0	COG0587@1|root,COG0587@2|Bacteria,1RINU@1224|Proteobacteria,2U9C7@28211|Alphaproteobacteria,4KMTC@93682|Roseivivax	28211|Alphaproteobacteria	L	DNA polymerase III	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	tRNA_anti-codon
TLS3_k127_4037918_4	391613.RTM1035_12578	4.899e-58	204.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,46QVR@74030|Roseovarius	28211|Alphaproteobacteria	C	Iron-sulfur cluster-binding protein	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
TLS3_k127_4037918_0	69279.BG36_02490	6.93e-236	741.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,2TR25@28211|Alphaproteobacteria,43NGV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Permease family	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
TLS3_k127_4037918_6	1038859.AXAU01000002_gene282	5.927e-32	130.0	COG2127@1|root,COG2127@2|Bacteria,1N0VF@1224|Proteobacteria,2UCNH@28211|Alphaproteobacteria,3JZDT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS3_k127_4037918_7	1168059.KB899087_gene3977	1.851e-31	136.0	COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2TSVU@28211|Alphaproteobacteria,3EZIS@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	FR47-like protein	MA20_25245	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_4037918_1	1525715.IX54_11895	1.695e-159	516.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2PVFX@265|Paracoccus	28211|Alphaproteobacteria	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS3_k127_4037918_3	935848.JAEN01000016_gene2358	2.443e-75	263.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,2PURN@265|Paracoccus	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS3_k127_4046194_0	1122218.KB893654_gene2169	1.971e-129	428.0	COG2199@1|root,COG3437@1|root,COG3437@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,1JSAU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM GGDEF domain containing protein	pleD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
TLS3_k127_4046194_1	1449350.OCH239_20660	4.722e-45	166.0	COG5349@1|root,COG5349@2|Bacteria,1MZDD@1224|Proteobacteria,2UCM4@28211|Alphaproteobacteria,4KMME@93682|Roseivivax	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
TLS3_k127_4046194_2	1417296.U879_02285	6.197e-24	108.0	COG0494@1|root,COG0494@2|Bacteria,1N8EV@1224|Proteobacteria,2TTNV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	MA20_36340	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_4070341_0	1294273.roselon_01390	8.754e-139	461.0	COG0642@1|root,COG2205@2|Bacteria,1QV2U@1224|Proteobacteria,2TW9G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS3_k127_4070341_1	388739.RSK20926_08717	4.591e-63	224.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,2P1T1@2433|Roseobacter	28211|Alphaproteobacteria	S	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems	senC	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
TLS3_k127_4075554_0	716928.AJQT01000067_gene3871	6.824e-293	923.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4B9W8@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	iorB	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
TLS3_k127_4075554_1	935557.ATYB01000008_gene5373	6.871e-69	244.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,4BCPG@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	[2Fe-2S] binding domain	iorA	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS3_k127_4075554_2	398580.Dshi_0845	5.303e-37	142.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,2TSKZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG0534 Na -driven multidrug efflux pump	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_4076014_4	1530186.JQEY01000001_gene881	5.409e-65	229.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-transferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_4076014_0	1381123.AYOD01000042_gene2143	2.891e-192	605.0	COG1840@1|root,COG1840@2|Bacteria,1Q13Q@1224|Proteobacteria,2TS7Y@28211|Alphaproteobacteria,43J3D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
TLS3_k127_4076014_1	1381123.AYOD01000043_gene1444	2.013e-140	470.0	COG4132@1|root,COG4132@2|Bacteria,1NF20@1224|Proteobacteria,2U0S4@28211|Alphaproteobacteria,43JHN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS3_k127_4076014_2	1381123.AYOD01000043_gene1445	2.249e-133	432.0	COG1177@1|root,COG1177@2|Bacteria,1MV4A@1224|Proteobacteria,2TUA3@28211|Alphaproteobacteria,43IW3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
TLS3_k127_4076014_3	1381123.AYOD01000043_gene1446	7.579e-103	351.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,43GT7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS3_k127_4102008_6	1122132.AQYH01000017_gene1032	1.967e-30	129.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TSPS@28211|Alphaproteobacteria,4BM5U@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_4102008_3	1123237.Salmuc_05404	5.124e-58	207.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2U79I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS3_k127_4102008_2	1041138.KB890258_gene2828	1.431e-64	224.0	COG3791@1|root,COG3791@2|Bacteria,1REMP@1224|Proteobacteria,2U61P@28211|Alphaproteobacteria,4BE73@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_4102008_1	864051.BurJ1DRAFT_2394	2.704e-66	231.0	COG3832@1|root,COG3832@2|Bacteria,1RA7N@1224|Proteobacteria,2VU3U@28216|Betaproteobacteria	28216|Betaproteobacteria	NT	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_4102008_4	366394.Smed_3513	7.855e-47	170.0	COG0640@1|root,COG0640@2|Bacteria,1RHUX@1224|Proteobacteria,2U9YE@28211|Alphaproteobacteria,4BFKB@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Sugar-specific transcriptional regulator TrmB	MA20_09440	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
TLS3_k127_4102008_5	1417296.U879_15695	3.967e-43	179.0	2CN5Z@1|root,32SGB@2|Bacteria,1N1FB@1224|Proteobacteria,2UBV1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2948)	MA20_21100	-	-	-	-	-	-	-	-	-	-	-	DUF2948
TLS3_k127_4102008_0	1469613.JT55_15230	1.358e-203	640.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,3FCRC@34008|Rhodovulum	28211|Alphaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
TLS3_k127_4106759_2	1287116.X734_05370	9.097e-144	464.0	COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,2TT7Q@28211|Alphaproteobacteria,43HEV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GM	epimerase dehydratase	-	-	4.1.1.35,5.1.3.10,5.1.3.2,5.1.3.25	ko:K01784,ko:K08678,ko:K12454,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R01384,R02984,R04266,R10279	RC00289,RC00508,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS3_k127_4106759_0	1370122.JHXQ01000007_gene3207	9.555e-277	884.0	COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,2TW46@28211|Alphaproteobacteria,4BBYQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Male sterility protein	rfbE	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS3_k127_4106759_1	1298858.AUEL01000003_gene5822	3.562e-215	674.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TUPK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
TLS3_k127_4106759_3	935557.ATYB01000008_gene5485	3.744e-10	61.0	COG0438@1|root,COG0438@2|Bacteria,1Q3IF@1224|Proteobacteria,2TVNS@28211|Alphaproteobacteria,4BC64@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_4108751_0	991905.SL003B_2510	2.165e-183	585.0	COG0847@1|root,COG2905@1|root,COG0847@2|Bacteria,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,4BQ0X@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	LT	Putative nucleotidyltransferase substrate binding domain	-	-	2.7.7.7	ko:K02342,ko:K07182	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	CBS,DUF294,DUF294_C,RNase_T
TLS3_k127_4108751_1	1280001.BAOA01000100_gene4460	8.332e-06	52.0	COG1388@1|root,COG1388@2|Bacteria,1P36H@1224|Proteobacteria,1SSMK@1236|Gammaproteobacteria,1XWQZ@135623|Vibrionales	135623|Vibrionales	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS3_k127_4112315_0	1122614.JHZF01000013_gene3468	8.663e-224	701.0	COG1488@1|root,COG1488@2|Bacteria,1MV8U@1224|Proteobacteria,2TREY@28211|Alphaproteobacteria,2PDQP@252301|Oceanicola	28211|Alphaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
TLS3_k127_4112315_1	501479.ACNW01000101_gene106	5.619e-83	282.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2TRMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Nicotinamidase	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS3_k127_4112315_3	1123360.thalar_01463	6.812e-11	68.0	2ENS6@1|root,33GDA@2|Bacteria,1NIB9@1224|Proteobacteria,2UMC4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
TLS3_k127_4112315_2	1122929.KB908225_gene3039	9.633e-70	247.0	COG3016@1|root,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,2U3QW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
TLS3_k127_4123981_0	349102.Rsph17025_2592	1.787e-116	381.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,1FAVS@1060|Rhodobacter	28211|Alphaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS3_k127_4123981_1	272943.RSP_1340	4.271e-115	376.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1FBI0@1060|Rhodobacter	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS3_k127_4123981_2	412597.AEPN01000008_gene2122	1.711e-34	134.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,2PXKH@265|Paracoccus	28211|Alphaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS3_k127_4123981_3	195105.CN97_08985	1.543e-13	76.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS3_k127_4124634_2	1101189.AQUO01000001_gene3547	7.594e-30	119.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,2PV9Y@265|Paracoccus	28211|Alphaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
TLS3_k127_4124634_0	62977.ACIAD1279	0.0	1189.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HJ	GNAT family acetyltransferase	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	ATP-grasp_5,CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK
TLS3_k127_4124634_1	642227.HA49_14185	3.811e-189	612.0	COG4242@1|root,COG4242@2|Bacteria,1R6CH@1224|Proteobacteria,1RPCF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	PQ	COG4242 Cyanophycinase and related exopeptidases	-	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
TLS3_k127_4143015_2	102129.Lepto7375DRAFT_6630	5.016e-07	63.0	COG4424@1|root,COG4424@2|Bacteria,1GQFR@1117|Cyanobacteria,1HD1A@1150|Oscillatoriales	1117|Cyanobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
TLS3_k127_4143015_0	999550.KI421507_gene270	2.194e-60	214.0	COG2227@1|root,COG2227@2|Bacteria,1RKPN@1224|Proteobacteria,2UB0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4143015_1	1122194.AUHU01000002_gene2909	1.433e-13	79.0	COG0438@1|root,COG0463@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,1QYCI@1224|Proteobacteria,1T5BB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_4147579_11	1469245.JFBG01000012_gene898	2.688e-106	361.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1RNTS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS3_k127_4147579_7	388399.SSE37_21980	1.407e-117	383.0	COG1129@1|root,COG1129@2|Bacteria,1MVNR@1224|Proteobacteria,2TTCM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS3_k127_4147579_0	1449351.RISW2_15430	5.949e-208	654.0	COG1653@1|root,COG1653@2|Bacteria,1MXZJ@1224|Proteobacteria,2TSFY@28211|Alphaproteobacteria,4KK57@93682|Roseivivax	28211|Alphaproteobacteria	G	Alpha-glucoside ABC transporter substrate-binding protein	aglE	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_4147579_8	1144312.PMI09_00764	2.628e-114	377.0	COG1028@1|root,COG1028@2|Bacteria,1MXE0@1224|Proteobacteria,2U1P2@28211|Alphaproteobacteria,4BDNJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_4147579_5	1469245.JFBG01000012_gene890	3.814e-136	450.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1RSE0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	2-dehydrogenase	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_4147579_13	1500301.JQMF01000005_gene3956	9.162e-105	349.0	COG1737@1|root,COG1737@2|Bacteria,1MW2B@1224|Proteobacteria,2TV88@28211|Alphaproteobacteria,4B7E2@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	SIS domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
TLS3_k127_4147579_10	1123501.KB902279_gene595	6.347e-111	365.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_4147579_19	290400.Jann_0773	9.494e-48	186.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,2UA4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_4147579_6	398580.Dshi_2889	1.367e-120	402.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TRDC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EQ	peptidase	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
TLS3_k127_4147579_16	314256.OG2516_11766	4.237e-69	243.0	COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2TTW2@28211|Alphaproteobacteria,2PDTZ@252301|Oceanicola	28211|Alphaproteobacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
TLS3_k127_4147579_4	371731.Rsw2DRAFT_0371	8.972e-140	458.0	COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2TSF2@28211|Alphaproteobacteria,1FB3P@1060|Rhodobacter	28211|Alphaproteobacteria	N	basal body rod protein	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
TLS3_k127_4147579_14	1469613.JT55_00420	8.743e-89	310.0	COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2TV1B@28211|Alphaproteobacteria,3FDEW@34008|Rhodovulum	28211|Alphaproteobacteria	N	flagellar hook-associated protein	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
TLS3_k127_4147579_22	1294273.roselon_01340	5.59e-21	109.0	COG1344@1|root,COG1344@2|Bacteria,1MVTB@1224|Proteobacteria,2TVAK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
TLS3_k127_4147579_2	1342302.JASC01000001_gene427	1.713e-155	498.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2TQNX@28211|Alphaproteobacteria,3ZWHB@60136|Sulfitobacter	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
TLS3_k127_4147579_23	187303.BN69_3300	3.854e-16	85.0	2DU34@1|root,33NRR@2|Bacteria,1PM3M@1224|Proteobacteria,2UQ6C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4147579_18	1381123.AYOD01000035_gene3545	7.158e-62	237.0	COG2327@1|root,COG2327@2|Bacteria,1RBBM@1224|Proteobacteria,2TTRA@28211|Alphaproteobacteria,43JHD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Polysaccharide pyruvyl transferase	exoV	-	-	ko:K16563	-	-	-	-	ko00000	-	-	-	PS_pyruv_trans
TLS3_k127_4147579_3	644107.SL1157_0973	3.529e-153	489.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,4N9VJ@97050|Ruegeria	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS3_k127_4147579_17	391624.OIHEL45_06855	1.052e-65	228.0	COG1846@1|root,COG1846@2|Bacteria,1RIX7@1224|Proteobacteria,2U94M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	petP	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS3_k127_4147579_12	644076.SCH4B_3250	3.784e-106	350.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TSQF@28211|Alphaproteobacteria,4NBHI@97050|Ruegeria	28211|Alphaproteobacteria	K	DNA-binding response regulator	petR	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_4147579_9	1040983.AXAE01000004_gene740	6.453e-112	377.0	COG2327@1|root,COG2327@2|Bacteria,1R6AN@1224|Proteobacteria,2U30E@28211|Alphaproteobacteria,43MZM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Polysaccharide pyruvyl transferase	amsJ	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
TLS3_k127_4147579_15	1410620.SHLA_22c000460	1.913e-69	250.0	COG1216@1|root,COG1216@2|Bacteria,1R89T@1224|Proteobacteria,2U78K@28211|Alphaproteobacteria,4BF53@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_4147579_24	941770.GL622181_gene591	7.917e-12	76.0	COG1442@1|root,COG1442@2|Bacteria,1UY8Y@1239|Firmicutes,4HBAE@91061|Bacilli,3F4YJ@33958|Lactobacillaceae	91061|Bacilli	M	family 8	arbY	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
TLS3_k127_4147579_1	1417296.U879_00205	2.203e-174	556.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038,ko:K21977	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS3_k127_4147579_20	1266998.ATUJ01000003_gene1658	1.141e-46	184.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2PWU6@265|Paracoccus	28211|Alphaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS3_k127_4147579_21	1429916.X566_10080	2.01e-27	117.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,3JQSR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	ThiF family	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
TLS3_k127_4173070_1	1449351.RISW2_22400	6.89e-23	107.0	COG3334@1|root,COG3334@2|Bacteria,1RKF6@1224|Proteobacteria,2UC98@28211|Alphaproteobacteria,4KMNZ@93682|Roseivivax	28211|Alphaproteobacteria	S	PFAM MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	MgtE_N
TLS3_k127_4173070_0	1188256.BASI01000001_gene451	5.193e-117	381.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,3FDQH@34008|Rhodovulum	28211|Alphaproteobacteria	N	MotA/TolQ/ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS3_k127_4179187_0	187303.BN69_2478	2.302e-58	216.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2TQRV@28211|Alphaproteobacteria,36Y60@31993|Methylocystaceae	28211|Alphaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
TLS3_k127_4179187_2	314271.RB2654_21048	4.94e-39	151.0	2AMDN@1|root,31C93@2|Bacteria,1Q89W@1224|Proteobacteria,2UVND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4179187_1	990285.RGCCGE502_16330	1.32e-53	198.0	2DQB4@1|root,335RD@2|Bacteria,1NEDH@1224|Proteobacteria,2V6NQ@28211|Alphaproteobacteria,4BCBJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS3_k127_4179187_3	1280947.HY30_05840	7.698e-25	107.0	COG0406@1|root,COG0406@2|Bacteria,1N14H@1224|Proteobacteria,2UF2M@28211|Alphaproteobacteria,43ZTG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS3_k127_4197556_0	1547437.LL06_08165	5.045e-112	376.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria,43IEH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS3_k127_4197556_1	666509.RCA23_c28660	2.949e-17	83.0	COG5508@1|root,COG5508@2|Bacteria,1N7D3@1224|Proteobacteria,2UF8M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	conserved small protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1674
TLS3_k127_4197556_2	1479237.JMLY01000001_gene2553	1.42e-07	59.0	2DNJ3@1|root,32XS3@2|Bacteria,1N5GA@1224|Proteobacteria,1S9KP@1236|Gammaproteobacteria,46C2I@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS3_k127_4197716_2	1122962.AULH01000020_gene3626	4.093e-14	72.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,36XA8@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_4197716_0	644107.SL1157_1071	4.27e-221	693.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,4NAQN@97050|Ruegeria	28211|Alphaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
TLS3_k127_4197716_1	272942.RCAP_rcc00035	2.471e-95	316.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,1FCJA@1060|Rhodobacter	28211|Alphaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
TLS3_k127_4234122_2	65497.JODV01000004_gene1594	6.413e-90	299.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4DYSV@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	mmsA	GO:0000166,GO:0003674,GO:0003824,GO:0004029,GO:0004030,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0006066,GO:0006067,GO:0006069,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0022900,GO:0031974,GO:0034308,GO:0036094,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070013,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901615	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_4234122_3	402881.Plav_2147	1.598e-82	286.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,1JNXV@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	PFAM 2-nitropropane dioxygenase NPD	MA20_36480	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
TLS3_k127_4234122_0	1547437.LL06_22110	5.04e-184	582.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,43H1W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_27425	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_4234122_1	314264.ROS217_23437	4.851e-118	406.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,46NHT@74030|Roseovarius	28211|Alphaproteobacteria	I	COG1024 Enoyl-CoA hydratase carnithine racemase	-	-	1.1.1.31,4.2.1.17	ko:K00020,ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05066,R05595,R06411,R06412,R06942,R08093	RC00099,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
TLS3_k127_4234122_4	411684.HPDFL43_08234	7.976e-63	239.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria,43I72@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS3_k127_4241543_2	349102.Rsph17025_2705	2.094e-83	283.0	COG0664@1|root,COG0664@2|Bacteria,1PIN3@1224|Proteobacteria,2TSFE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	fixK	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_4241543_4	1449350.OCH239_03005	1.141e-33	133.0	COG3631@1|root,COG3631@2|Bacteria,1N487@1224|Proteobacteria,2UBRI@28211|Alphaproteobacteria,4KMY9@93682|Roseivivax	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS3_k127_4241543_0	1337093.MBE-LCI_0688	2.25e-309	966.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	'PFAM Alpha amylase, catalytic	-	-	2.4.1.4,2.4.1.7	ko:K00690,ko:K05341	ko00500,map00500	-	R00803,R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
TLS3_k127_4241543_3	1410620.SHLA_26c000790	2.063e-52	194.0	COG1309@1|root,COG1309@2|Bacteria,1RHSR@1224|Proteobacteria,2UBF3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_4241543_1	1410620.SHLA_26c000800	6.657e-119	394.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,4BANF@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS3_k127_4241543_5	1188256.BASI01000001_gene805	2.332e-09	61.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,3FCYN@34008|Rhodovulum	28211|Alphaproteobacteria	J	Probable RNA and SrmB- binding site of polymerase A	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
TLS3_k127_4242465_2	1122132.AQYH01000017_gene1032	9.203e-68	231.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TSPS@28211|Alphaproteobacteria,4BM5U@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_4242465_1	1122132.AQYH01000017_gene1033	1.982e-119	400.0	COG2017@1|root,COG2017@2|Bacteria,1RBJD@1224|Proteobacteria,2U5RH@28211|Alphaproteobacteria,4BIXD@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4242465_0	1188256.BASI01000001_gene485	0.0	1017.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,3FCHR@34008|Rhodovulum	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS3_k127_4253751_6	290400.Jann_3165	2.207e-36	145.0	COG2197@1|root,COG2197@2|Bacteria,1RA3V@1224|Proteobacteria,2U0I0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	kdpE	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_4253751_2	398580.Dshi_2658	5.541e-117	387.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS3_k127_4253751_0	1123360.thalar_02255	0.0	1345.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_4253751_4	290400.Jann_1763	2.002e-76	259.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS3_k127_4253751_3	246200.SPO1511	3.831e-98	328.0	COG1131@1|root,COG1131@2|Bacteria,1MX56@1224|Proteobacteria,2TTQM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	MA20_34505	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_4253751_1	1461693.ATO10_01255	1.631e-129	421.0	COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria,2TSUF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	transport, permease protein	MA20_34500	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS3_k127_4253751_5	296591.Bpro_0095	2.348e-74	259.0	COG2186@1|root,COG2186@2|Bacteria,1N6N0@1224|Proteobacteria,2VPN3@28216|Betaproteobacteria,4AHF4@80864|Comamonadaceae	28216|Betaproteobacteria	K	FadR C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_4259884_1	983917.RGE_39170	1.402e-143	463.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,1KKDD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TLS3_k127_4259884_7	349102.Rsph17025_0396	7.69e-42	162.0	COG1247@1|root,COG1247@2|Bacteria,1RDNE@1224|Proteobacteria,2U9BP@28211|Alphaproteobacteria,1FBV1@1060|Rhodobacter	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	yncA	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
TLS3_k127_4259884_3	1469613.JT55_15745	2.143e-81	281.0	COG1268@1|root,COG1268@2|Bacteria,1RH78@1224|Proteobacteria,2U9DN@28211|Alphaproteobacteria,3FE4A@34008|Rhodovulum	28211|Alphaproteobacteria	S	BioY family	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
TLS3_k127_4259884_5	1449065.JMLL01000011_gene2214	1.143e-56	203.0	COG3506@1|root,COG3506@2|Bacteria,1RGKQ@1224|Proteobacteria,2U7X8@28211|Alphaproteobacteria,43PBH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1349)	-	-	-	ko:K09702	-	-	-	-	ko00000	-	-	-	DUF1349
TLS3_k127_4259884_6	501479.ACNW01000097_gene1080	6.706e-51	199.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,2U8FN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
TLS3_k127_4259884_4	1509405.GV67_08120	9.767e-66	237.0	COG2327@1|root,COG2327@2|Bacteria,1RBBM@1224|Proteobacteria,2TTRA@28211|Alphaproteobacteria,4BBHI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Succinoglycan biosynthesis protein	exoV	-	2.5.1.98	ko:K16563,ko:K21154	-	-	-	-	ko00000,ko01000	-	-	-	PS_pyruv_trans
TLS3_k127_4259884_2	1461693.ATO10_01705	1.303e-88	297.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	acetolactate synthase	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TLS3_k127_4259884_0	314256.OG2516_15604	7.692e-282	871.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,2PCPF@252301|Oceanicola	28211|Alphaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_4275690_3	1231392.OCGS_1815	2.178e-58	211.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2TSXY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane protein, hemolysin III homolog	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
TLS3_k127_4275690_2	1449351.RISW2_13850	2.142e-81	287.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,4KKW6@93682|Roseivivax	28211|Alphaproteobacteria	S	Cob(I)yrinic acid a,c-diamide adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS3_k127_4275690_5	195105.CN97_11655	3.057e-16	80.0	2E3XR@1|root,32YUS@2|Bacteria,1N8QN@1224|Proteobacteria,2UFB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Hypoxia induced protein conserved region	-	-	-	-	-	-	-	-	-	-	-	-	HIG_1_N
TLS3_k127_4275690_4	477641.MODMU_4082	1.11e-22	100.0	2EE1U@1|root,337WK@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
TLS3_k127_4275690_7	1500304.JQKY01000004_gene1552	0.0001442	49.0	2ADDQ@1|root,3133F@2|Bacteria,1PRQJ@1224|Proteobacteria,2V3Z5@28211|Alphaproteobacteria,4BFN0@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4275690_1	1082933.MEA186_18240	2.333e-105	349.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria,43GT3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS3_k127_4275690_0	1502724.FF80_01864	1.812e-135	451.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TTSX@28211|Alphaproteobacteria,3N7YZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
TLS3_k127_4277827_1	349102.Rsph17025_1063	5.003e-56	201.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2TUVR@28211|Alphaproteobacteria,1FCQU@1060|Rhodobacter	28211|Alphaproteobacteria	S	Colicin V production protein	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
TLS3_k127_4277827_0	1417296.U879_14020	5.598e-204	644.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
TLS3_k127_428227_3	1188256.BASI01000002_gene3386	1.503e-126	410.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,3FCVK@34008|Rhodovulum	28211|Alphaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
TLS3_k127_428227_4	412597.AEPN01000004_gene3272	4.998e-39	156.0	COG2606@1|root,COG2606@2|Bacteria,1RD82@1224|Proteobacteria,2U7H0@28211|Alphaproteobacteria,2PWYF@265|Paracoccus	28211|Alphaproteobacteria	S	Aminoacyl-tRNA editing domain	ybaK	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS3_k127_428227_0	1469613.JT55_11315	1.149e-243	759.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,3FCPZ@34008|Rhodovulum	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_428227_1	1122218.KB893653_gene1363	1.052e-200	634.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,1JSPA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS3_k127_428227_2	1188256.BASI01000002_gene3678	4.459e-151	502.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,3FD4W@34008|Rhodovulum	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4131)	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
TLS3_k127_428227_5	935565.JAEM01000034_gene2506	7.432e-15	77.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,2PW9Q@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function DUF72	MA20_09500	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS3_k127_4339209_0	1105367.CG50_10900	5.028e-153	499.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2TRXU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	COG1157 Flagellar biosynthesis type III secretory pathway ATPase	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS3_k127_4339209_1	195105.CN97_13360	1.983e-10	63.0	COG1815@1|root,COG1815@2|Bacteria,1N1G1@1224|Proteobacteria,2UCJ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
TLS3_k127_4347390_0	1185766.DL1_04850	1.572e-138	447.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2TUNR@28211|Alphaproteobacteria,2XKQ3@285107|Thioclava	28211|Alphaproteobacteria	J	SAM-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS3_k127_4347390_2	1123237.Salmuc_03748	6.873e-48	187.0	COG1569@1|root,COG1569@2|Bacteria,1RCZE@1224|Proteobacteria,2U5DQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TLS3_k127_4347390_1	1123237.Salmuc_04512	3.038e-115	380.0	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS3_k127_4384742_2	391619.PGA1_c35690	1.384e-10	74.0	COG3118@1|root,COG3118@2|Bacteria,1R8CU@1224|Proteobacteria,2U2AN@28211|Alphaproteobacteria,34E4D@302485|Phaeobacter	28211|Alphaproteobacteria	O	belongs to the thioredoxin family	flaA	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4384742_0	391613.RTM1035_20271	3.007e-135	452.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,46Q2V@74030|Roseovarius	28211|Alphaproteobacteria	N	MotA/TolQ/ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS3_k127_4384742_1	1415756.JQMY01000001_gene396	4.436e-31	129.0	COG3334@1|root,COG3334@2|Bacteria,1RKF6@1224|Proteobacteria,2UC98@28211|Alphaproteobacteria,2PEJ3@252301|Oceanicola	28211|Alphaproteobacteria	S	PFAM MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	MgtE_N
TLS3_k127_4448402_2	1173264.KI913949_gene1115	1.289e-22	110.0	COG0739@1|root,COG1404@1|root,COG4257@1|root,COG0739@2|Bacteria,COG1404@2|Bacteria,COG4257@2|Bacteria,1G7B0@1117|Cyanobacteria,1HBXD@1150|Oscillatoriales	1117|Cyanobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_4448402_0	1381123.AYOD01000015_gene2393	5.795e-167	533.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,43JFM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	livJ	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS3_k127_4448402_1	1381123.AYOD01000015_gene2394	3.288e-122	396.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,43JH8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	livG1	-	-	ko:K01995,ko:K11957	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_4461369_0	1305735.JAFT01000005_gene2211	1.325e-239	746.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2PD3B@252301|Oceanicola	28211|Alphaproteobacteria	C	Cytochrome bd terminal oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
TLS3_k127_4461369_1	1305735.JAFT01000005_gene2212	2.247e-174	553.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,2PCWE@252301|Oceanicola	28211|Alphaproteobacteria	C	Cytochrome bd terminal oxidase subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TLS3_k127_4461369_3	114615.BRADO3291	4.255e-78	273.0	COG0300@1|root,COG0300@2|Bacteria,1RBH6@1224|Proteobacteria,2U68F@28211|Alphaproteobacteria,3K3WB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_4461369_2	644107.SL1157_A0151	4.154e-130	421.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4NBJP@97050|Ruegeria	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	mltK	-	-	ko:K10191	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	ABC_tran,TOBE_2
TLS3_k127_447137_1	1317124.DW2_17235	3.355e-138	456.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2XMAD@285107|Thioclava	28211|Alphaproteobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS3_k127_447137_2	648885.KB316286_gene2557	6.463e-87	311.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRGU@28211|Alphaproteobacteria,1JRKK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	BQ	PFAM Histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS3_k127_447137_3	1122132.AQYH01000020_gene60	5.624e-09	61.0	2DHRA@1|root,300N8@2|Bacteria,1Q6D5@1224|Proteobacteria,2VCIT@28211|Alphaproteobacteria,4BHU0@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_447137_0	266834.SM_b20049	8.16e-207	662.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,4B8BS@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	elongation factor G	MA20_05220	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS3_k127_4500224_9	441620.Mpop_2813	2.57e-06	50.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,1JTHW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_4500224_8	1429916.X566_00070	4.351e-08	60.0	COG2608@1|root,COG2608@2|Bacteria,1PUDP@1224|Proteobacteria,2V0M9@28211|Alphaproteobacteria,3K1Y7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
TLS3_k127_4500224_6	935840.JAEQ01000010_gene1564	1.363e-38	148.0	COG3544@1|root,COG3544@2|Bacteria,1N0KY@1224|Proteobacteria,2UC2H@28211|Alphaproteobacteria,43KSF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS3_k127_4500224_5	761193.Runsl_3699	3.269e-53	196.0	COG0745@1|root,COG0745@2|Bacteria,4NIP5@976|Bacteroidetes,47K0M@768503|Cytophagia	976|Bacteroidetes	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07665,ko:K07669	ko02020,map02020	M00452,M00460,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_4500224_4	1185652.USDA257_c24120	6.957e-82	293.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1N5YU@1224|Proteobacteria,2TTXK@28211|Alphaproteobacteria,4BC2F@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_4500224_2	887898.HMPREF0551_1540	2.253e-107	363.0	COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,2VRM8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
TLS3_k127_4500224_1	398580.Dshi_1993	1.976e-135	447.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	redB	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS3_k127_4500224_3	398580.Dshi_1992	4.762e-94	328.0	COG0438@1|root,COG0438@2|Bacteria,1PEWW@1224|Proteobacteria,2U2ZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_4500224_0	1229172.JQFA01000002_gene2794	1.878e-189	618.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1H7BU@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_4500224_7	598467.BrE312_2834	6.198e-17	90.0	COG0510@1|root,COG3173@1|root,COG0510@2|Bacteria,COG3173@2|Bacteria,1MXSM@1224|Proteobacteria,1SM6U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_4515077_2	388399.SSE37_17248	1.043e-09	59.0	COG3951@1|root,COG3951@2|Bacteria,1N8ET@1224|Proteobacteria,2UF4I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Flagellar protein FlgJ	flgJ	-	-	-	-	-	-	-	-	-	-	-	Rod-binding
TLS3_k127_4515077_0	1126627.BAWE01000004_gene1937	1.662e-81	284.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria,3JVXR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_4515077_1	314270.RB2083_40	5.51e-18	89.0	COG3677@1|root,COG3677@2|Bacteria,1R999@1224|Proteobacteria,2UD3G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595
TLS3_k127_4534358_1	1417296.U879_00565	1.202e-205	666.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_4534358_4	1089551.KE386572_gene3916	2.273e-27	121.0	COG3685@1|root,COG3685@2|Bacteria,1R4MJ@1224|Proteobacteria,2U9EB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
TLS3_k127_4534358_0	1185766.DL1_03610	2.037e-223	700.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2XMQD@285107|Thioclava	28211|Alphaproteobacteria	C	catalyzes the oxidation of dihydrolipoamide to lipoamide	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_4534358_3	314232.SKA53_14511	1.492e-52	188.0	COG3686@1|root,COG3686@2|Bacteria,1N00R@1224|Proteobacteria,2U94Y@28211|Alphaproteobacteria,2P912@245186|Loktanella	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
TLS3_k127_4534358_2	1472418.BBJC01000001_gene343	5.03e-76	256.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_4550831_3	349163.Acry_1069	1.627e-102	361.0	COG0287@1|root,COG0287@2|Bacteria,1QN63@1224|Proteobacteria,2TT5P@28211|Alphaproteobacteria,2JVN1@204441|Rhodospirillales	204441|Rhodospirillales	E	Phosphogluconate dehydrogenase (decarboxylating) C-term	-	-	-	-	-	-	-	-	-	-	-	-	PGDH_C
TLS3_k127_4550831_1	1123229.AUBC01000012_gene2685	4.114e-146	485.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2TS85@28211|Alphaproteobacteria,3JXET@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative sugar-binding N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
TLS3_k127_4550831_0	1123229.AUBC01000012_gene2686	3.812e-208	662.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2TSJV@28211|Alphaproteobacteria,3JWJK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Ribulose bisphosphate carboxylase large chain, catalytic domain	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
TLS3_k127_4550831_2	1123229.AUBC01000012_gene2687	7.078e-115	377.0	COG0673@1|root,COG0673@2|Bacteria,1MW74@1224|Proteobacteria,2TSFH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_4551164_0	1415756.JQMY01000001_gene3028	1.795e-212	683.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2PDQG@252301|Oceanicola	28211|Alphaproteobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TLS3_k127_4551164_3	1446473.JHWH01000001_gene1011	2.968e-11	76.0	2C7S8@1|root,32RJQ@2|Bacteria,1N2C7@1224|Proteobacteria,2UBZK@28211|Alphaproteobacteria,2PWPU@265|Paracoccus	28211|Alphaproteobacteria	-	-	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	-
TLS3_k127_4551164_2	349102.Rsph17025_1601	5.84e-105	348.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,1FBDE@1060|Rhodobacter	28211|Alphaproteobacteria	M	shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
TLS3_k127_4551164_1	1002340.AFCF01000062_gene846	3.309e-182	576.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria,34EPF@302485|Phaeobacter	28211|Alphaproteobacteria	D	Actin	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
TLS3_k127_4552088_2	1525715.IX54_12635	8.943e-180	572.0	COG4277@1|root,COG4277@2|Bacteria,1MVCV@1224|Proteobacteria,2TT5U@28211|Alphaproteobacteria,2PUGE@265|Paracoccus	28211|Alphaproteobacteria	S	Helix-hairpin-helix DNA-binding motif class 1	MA20_15955	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS3_k127_4552088_3	314264.ROS217_16025	9.817e-20	96.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,46S10@74030|Roseovarius	28211|Alphaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	csbD	-	-	-	-	-	-	-	-	-	-	-	CsbD
TLS3_k127_4552088_0	266779.Meso_2421	2.201e-297	926.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VF2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS3_k127_4552088_1	648885.KB316282_gene286	4.774e-195	619.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,1JSE8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
TLS3_k127_4559843_1	991905.SL003B_0721	7.937e-110	361.0	COG1540@1|root,COG1540@2|Bacteria,1MUYV@1224|Proteobacteria,2TQUC@28211|Alphaproteobacteria,4BQE6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0271 (lamB) family	ybgL	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
TLS3_k127_4559843_0	349102.Rsph17025_1048	1.445e-146	471.0	COG0436@1|root,COG0436@2|Bacteria,1MUHD@1224|Proteobacteria,2TRDR@28211|Alphaproteobacteria,1FANS@1060|Rhodobacter	28211|Alphaproteobacteria	H	PFAM Aminotransferase class I and II	aspC4	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS3_k127_4580625_0	571166.KI421509_gene3848	1.011e-142	469.0	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2TSQJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane-anchored protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
TLS3_k127_4580625_1	1121271.AUCM01000006_gene374	1.071e-121	410.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TLS3_k127_4580625_2	371731.Rsw2DRAFT_0497	1.172e-77	263.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,1FAVN@1060|Rhodobacter	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TLS3_k127_4609570_1	1380391.JIAS01000005_gene2418	1.613e-79	274.0	COG2186@1|root,COG2186@2|Bacteria,1R8FM@1224|Proteobacteria,2U056@28211|Alphaproteobacteria,2JZE1@204441|Rhodospirillales	204441|Rhodospirillales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_4609570_0	1168059.KB899087_gene2620	1.226e-133	457.0	2CB42@1|root,2Z7Y3@2|Bacteria,1PK1X@1224|Proteobacteria,2TVBX@28211|Alphaproteobacteria,3F16F@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4615252_4	1472418.BBJC01000003_gene1515	7.518e-27	118.0	COG4765@1|root,COG4765@2|Bacteria,1RHI7@1224|Proteobacteria,2UBR9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2155
TLS3_k127_4615252_2	252305.OB2597_05855	4.021e-40	159.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2UCHU@28211|Alphaproteobacteria,2PE5I@252301|Oceanicola	28211|Alphaproteobacteria	Q	COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
TLS3_k127_4615252_0	1417296.U879_00870	2.725e-57	202.0	COG3761@1|root,COG3761@2|Bacteria,1RHS3@1224|Proteobacteria,2U95G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase 17.2 kD subunit	MA20_29090	-	1.6.99.3	ko:K00356	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	NDUFA12
TLS3_k127_4615252_1	935261.JAGL01000017_gene2731	8.394e-48	182.0	COG0834@1|root,COG0834@2|Bacteria,1N6H5@1224|Proteobacteria,2U5FP@28211|Alphaproteobacteria,43I69@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	ET	PFAM Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS3_k127_4615252_3	766499.C357_19196	4.391e-33	129.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
TLS3_k127_46265_6	693986.MOC_0709	3.371e-08	59.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,1JR27@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
TLS3_k127_46265_5	999549.KI421513_gene3203	1.177e-41	168.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,280BW@191028|Leisingera	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
TLS3_k127_46265_1	1415756.JQMY01000001_gene2716	8.653e-154	512.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,2PC7G@252301|Oceanicola	28211|Alphaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
TLS3_k127_46265_2	252305.OB2597_02597	3.293e-80	286.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,2PCN2@252301|Oceanicola	28211|Alphaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS3_k127_46265_3	1305735.JAFT01000005_gene3453	2.013e-66	241.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2TQUB@28211|Alphaproteobacteria,2PCKN@252301|Oceanicola	28211|Alphaproteobacteria	S	Predicted permease YjgP/YjgQ family	MA20_28210	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
TLS3_k127_46265_0	1231392.OCGS_0047	6.002e-186	595.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS3_k127_46265_4	1123237.Salmuc_00239	1.462e-42	162.0	COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase III, chi subunit	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
TLS3_k127_4646001_0	195105.CN97_13805	0.0	1279.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
TLS3_k127_4646001_4	1342302.JASC01000013_gene2975	2.597e-67	240.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,3ZUWJ@60136|Sulfitobacter	28211|Alphaproteobacteria	O	peptidyl-prolyl isomerase	ppiC	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
TLS3_k127_4646001_2	1469613.JT55_00820	5.633e-153	499.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,3FCMD@34008|Rhodovulum	28211|Alphaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS3_k127_4646001_5	314256.OG2516_11141	1.977e-59	226.0	COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria,2PE5P@252301|Oceanicola	28211|Alphaproteobacteria	L	NUDIX domain	mutT	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Acetyltransf_3,NUDIX,NUDIX_4
TLS3_k127_4646001_7	1337093.MBE-LCI_0790	3.205e-06	51.0	2C9A2@1|root,339RZ@2|Bacteria,1NGPJ@1224|Proteobacteria,2UJXS@28211|Alphaproteobacteria,2PA23@245186|Loktanella	28211|Alphaproteobacteria	S	Translation initiation factor 2	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4646001_1	1380358.JADJ01000005_gene2829	5.016e-168	547.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1XH4R@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS3_k127_4646001_3	1121271.AUCM01000006_gene122	1.796e-88	301.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	bioC	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS3_k127_4646001_6	1105367.CG50_11200	4.003e-51	188.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
TLS3_k127_464811_6	1288298.rosmuc_02815	1.689e-61	216.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,46NGC@74030|Roseovarius	28211|Alphaproteobacteria	V	COG3023 Negative regulator of beta-lactamase expression	ampD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	2.5.1.3,3.5.1.28	ko:K00788,ko:K01447,ko:K03806,ko:K11066	ko00730,ko01100,map00730,map01100	M00127	R03223,R04112,R10712	RC00064,RC00141,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Amidase_2,PG_binding_1
TLS3_k127_464811_9	83219.PM02_12955	6.809e-22	105.0	2AYG7@1|root,31QJH@2|Bacteria,1RE73@1224|Proteobacteria,2U6WH@28211|Alphaproteobacteria,3ZWAU@60136|Sulfitobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_464811_0	1469613.JT55_05405	1.321e-239	748.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,3FCMT@34008|Rhodovulum	28211|Alphaproteobacteria	F	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS3_k127_464811_8	1461693.ATO10_14289	1.743e-31	139.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS3_k127_464811_5	398580.Dshi_2787	2.758e-66	236.0	2D1C5@1|root,32TAD@2|Bacteria,1N23F@1224|Proteobacteria,2U94F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
TLS3_k127_464811_3	1188256.BASI01000002_gene3056	6.642e-108	353.0	COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2TV26@28211|Alphaproteobacteria,3FD66@34008|Rhodovulum	28211|Alphaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS3_k127_464811_7	1123237.Salmuc_05439	3.28e-44	174.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2UD3W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS3_k127_464811_2	1469613.JT55_02535	3.162e-117	398.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,3FCZK@34008|Rhodovulum	28211|Alphaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS3_k127_464811_10	272942.RCAP_rcc02381	1.772e-17	93.0	COG5462@1|root,COG5462@2|Bacteria,1N1DA@1224|Proteobacteria,2UBXT@28211|Alphaproteobacteria,1FC3X@1060|Rhodobacter	28211|Alphaproteobacteria	S	secreted (Periplasmic) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_464811_1	1288298.rosmuc_03074	1.243e-218	707.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,46PAW@74030|Roseovarius	28211|Alphaproteobacteria	M	COG0768 Cell division protein FtsI penicillin-binding protein 2	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TLS3_k127_464811_4	1317124.DW2_13095	1.513e-83	304.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,2XKIS@285107|Thioclava	28211|Alphaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_4648995_2	460265.Mnod_5656	2.327e-21	101.0	2FDWQ@1|root,345X5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4648995_1	391593.RCCS2_04314	4.768e-33	133.0	COG1846@1|root,COG1846@2|Bacteria,1RD9U@1224|Proteobacteria,2U7NF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR_2
TLS3_k127_4648995_0	83219.PM02_12205	9.998e-111	364.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,2TR3E@28211|Alphaproteobacteria,3ZX3Y@60136|Sulfitobacter	28211|Alphaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS3_k127_4657590_0	644107.SL1157_0138	9.389e-183	576.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,2TQNS@28211|Alphaproteobacteria,4N9XX@97050|Ruegeria	28211|Alphaproteobacteria	EG	Belongs to the IlvD Edd family	edd	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS3_k127_4657590_1	1353531.AZNX01000005_gene3712	3.824e-56	205.0	COG0412@1|root,COG0412@2|Bacteria,1MYJ9@1224|Proteobacteria,2UBAU@28211|Alphaproteobacteria,4BA2W@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS3_k127_4657590_2	388739.RSK20926_10519	2.135e-17	83.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,2P2E9@2433|Roseobacter	28211|Alphaproteobacteria	G	COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase	eda	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
TLS3_k127_46642_0	398580.Dshi_0674	4.657e-129	419.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
TLS3_k127_46642_2	331869.BAL199_27196	4.467e-15	85.0	COG0789@1|root,COG0789@2|Bacteria,1N831@1224|Proteobacteria,2UFMB@28211|Alphaproteobacteria,4BSX4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
TLS3_k127_46642_1	1417296.U879_09680	2.066e-65	228.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	chaperone	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
TLS3_k127_4669180_0	349102.Rsph17025_2244	3.245e-127	415.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,1FCMV@1060|Rhodobacter	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	tdcB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017144,GO:0018249,GO:0019538,GO:0019752,GO:0019842,GO:0030170,GO:0030378,GO:0030848,GO:0036094,GO:0036211,GO:0036361,GO:0042219,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0047661,GO:0048037,GO:0050662,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_4669180_2	1188256.BASI01000005_gene1985	1.703e-83	305.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2TT0S@28211|Alphaproteobacteria,3FD4I@34008|Rhodovulum	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_4669180_3	1188256.BASI01000005_gene1984	4.771e-69	261.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2TS5K@28211|Alphaproteobacteria,3FD6W@34008|Rhodovulum	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	dehII	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
TLS3_k127_4669180_1	1122614.JHZF01000013_gene3584	8.569e-118	384.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2PDK2@252301|Oceanicola	28211|Alphaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_4669180_4	1267005.KB911257_gene758	4.639e-17	81.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,3N65J@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS3_k127_4681248_1	441620.Mpop_4923	3.93e-121	397.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria,1JT2Q@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS3_k127_4681248_0	1123360.thalar_03196	7.147e-270	843.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_4681248_2	398580.Dshi_0674	4.027e-120	428.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
TLS3_k127_4681248_3	1417296.U879_09705	2.514e-33	135.0	2ASBV@1|root,31HR4@2|Bacteria,1RKAJ@1224|Proteobacteria,2UB0D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4681248_4	351016.RAZWK3B_08666	1.566e-10	66.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2P2NK@2433|Roseobacter	28211|Alphaproteobacteria	V	Protein export membrane protein	acrF	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
TLS3_k127_4681248_5	935557.ATYB01000008_gene5922	1.14e-07	62.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TU0W@28211|Alphaproteobacteria,4BBS2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
TLS3_k127_470770_2	666509.RCA23_c02500	2.521e-110	365.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,T2SSE_N
TLS3_k127_470770_3	1208323.B30_03912	1.207e-89	300.0	COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,2TUKM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_470770_4	1449351.RISW2_13500	5.548e-88	295.0	COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,2TUDN@28211|Alphaproteobacteria,4KKWP@93682|Roseivivax	28211|Alphaproteobacteria	S	Pyrimidine 5'-nucleotidase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS3_k127_470770_1	1469613.JT55_17525	5.204e-127	419.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TT9M@28211|Alphaproteobacteria,3FD2H@34008|Rhodovulum	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS3_k127_470770_0	1417296.U879_02360	4.116e-221	691.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	trimethylamine methyltransferase	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
TLS3_k127_4707858_1	349102.Rsph17025_0793	2.403e-126	413.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2TTET@28211|Alphaproteobacteria,1FCMM@1060|Rhodobacter	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	cysT	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
TLS3_k127_4707858_0	1569209.BBPH01000117_gene3680	1.702e-165	528.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2TT52@28211|Alphaproteobacteria,2PU6C@265|Paracoccus	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
TLS3_k127_4708214_0	34007.IT40_04300	1.506e-74	265.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2TTF9@28211|Alphaproteobacteria,2PUZD@265|Paracoccus	28211|Alphaproteobacteria	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS3_k127_4708214_2	78245.Xaut_1492	3.897e-24	118.0	COG4319@1|root,COG4319@2|Bacteria,1RII1@1224|Proteobacteria,2V6QK@28211|Alphaproteobacteria,3F1VH@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4440
TLS3_k127_4708214_1	1461693.ATO10_08788	9.15e-48	180.0	COG3793@1|root,COG3793@2|Bacteria,1RD1X@1224|Proteobacteria,2U788@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM Mo-dependent nitrogenase	-	-	-	-	-	-	-	-	-	-	-	-	TerB
TLS3_k127_4723394_4	1446473.JHWH01000006_gene1808	6.516e-30	120.0	COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria,2PXM8@265|Paracoccus	28211|Alphaproteobacteria	T	Belongs to the BolA IbaG family	MA20_09125	-	-	-	-	-	-	-	-	-	-	-	BolA
TLS3_k127_4723394_2	1123247.AUIJ01000009_gene3067	1.351e-55	196.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grlA	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
TLS3_k127_4723394_1	644076.SCH4B_1640	2.436e-56	203.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2TUIY@28211|Alphaproteobacteria,4NBZU@97050|Ruegeria	28211|Alphaproteobacteria	S	CoA-binding domain protein	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS3_k127_4723394_0	1188256.BASI01000001_gene1358	6.638e-98	328.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,3FD3G@34008|Rhodovulum	28211|Alphaproteobacteria	J	RNA 2'-O ribose methyltransferase substrate binding	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
TLS3_k127_4723394_5	29730.Gorai.001G164700.1	0.0003683	45.0	2B8KU@1|root,2S0S2@2759|Eukaryota,37UKM@33090|Viridiplantae,3GJ2Y@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4723394_3	1122180.Lokhon_00990	9.189e-42	156.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,2P85J@245186|Loktanella	28211|Alphaproteobacteria	J	tRNA synthetases class I (K)	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
TLS3_k127_4739864_2	1304878.AUGD01000010_gene4634	6.768e-39	151.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TYRW@28211|Alphaproteobacteria,3JT84@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	MA20_37370	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS3_k127_4739864_0	1380394.JADL01000009_gene3204	4.181e-190	606.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,2JRHT@204441|Rhodospirillales	204441|Rhodospirillales	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_4739864_1	1089551.KE386572_gene125	1.735e-136	443.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TW5I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	MA20_37380	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS3_k127_4739864_3	7217.FBpp0121191	1.073e-05	53.0	KOG1306@1|root,KOG1306@2759|Eukaryota,38CSX@33154|Opisthokonta,3BAVY@33208|Metazoa,3CSR1@33213|Bilateria,41V4G@6656|Arthropoda,3SHYQ@50557|Insecta,44ZMX@7147|Diptera,45W4K@7214|Drosophilidae	33208|Metazoa	P	Calcium sodium antiporter activity. It is involved in the biological process described with cell communication	SLC8A3	GO:0000003,GO:0000302,GO:0001508,GO:0001666,GO:0001701,GO:0001890,GO:0001892,GO:0002026,GO:0002027,GO:0002028,GO:0002244,GO:0002376,GO:0002520,GO:0003006,GO:0003007,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003018,GO:0003674,GO:0005215,GO:0005432,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005783,GO:0005789,GO:0005856,GO:0005874,GO:0005886,GO:0005887,GO:0005901,GO:0005911,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006816,GO:0006851,GO:0006873,GO:0006874,GO:0006875,GO:0006883,GO:0006936,GO:0006937,GO:0006939,GO:0006941,GO:0006942,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0007204,GO:0007272,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007507,GO:0007584,GO:0007602,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0008015,GO:0008016,GO:0008092,GO:0008150,GO:0008324,GO:0008366,GO:0009314,GO:0009410,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009605,GO:0009612,GO:0009628,GO:0009636,GO:0009653,GO:0009719,GO:0009743,GO:0009746,GO:0009749,GO:0009790,GO:0009791,GO:0009792,GO:0009887,GO:0009888,GO:0009987,GO:0009991,GO:0010001,GO:0010033,GO:0010035,GO:0010243,GO:0010522,GO:0010644,GO:0010646,GO:0010647,GO:0010649,GO:0010762,GO:0010763,GO:0010880,GO:0010881,GO:0010882,GO:0010959,GO:0012505,GO:0014070,GO:0014074,GO:0014704,GO:0014706,GO:0014819,GO:0014829,GO:0015075,GO:0015077,GO:0015081,GO:0015085,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015630,GO:0015672,GO:0016020,GO:0016021,GO:0016323,GO:0019722,GO:0019725,GO:0019867,GO:0019932,GO:0021537,GO:0022008,GO:0022414,GO:0022804,GO:0022857,GO:0022890,GO:0023051,GO:0023052,GO:0023056,GO:0030001,GO:0030003,GO:0030004,GO:0030016,GO:0030017,GO:0030018,GO:0030054,GO:0030097,GO:0030154,GO:0030278,GO:0030315,GO:0030334,GO:0030335,GO:0030425,GO:0030500,GO:0030501,GO:0030506,GO:0030900,GO:0031000,GO:0031090,GO:0031224,GO:0031226,GO:0031594,GO:0031667,GO:0031674,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0031981,GO:0031984,GO:0032501,GO:0032502,GO:0032879,GO:0033198,GO:0033273,GO:0033280,GO:0033554,GO:0033993,GO:0034220,GO:0034284,GO:0034599,GO:0034614,GO:0034762,GO:0034765,GO:0034976,GO:0035050,GO:0035051,GO:0035150,GO:0035295,GO:0035296,GO:0035556,GO:0035637,GO:0035690,GO:0035725,GO:0035902,GO:0035994,GO:0036270,GO:0036293,GO:0036294,GO:0036376,GO:0036477,GO:0040012,GO:0040017,GO:0042063,GO:0042175,GO:0042221,GO:0042310,GO:0042383,GO:0042391,GO:0042493,GO:0042542,GO:0042552,GO:0042592,GO:0042692,GO:0042995,GO:0043005,GO:0043009,GO:0043025,GO:0043167,GO:0043169,GO:0043197,GO:0043198,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043269,GO:0043279,GO:0043292,GO:0044057,GO:0044291,GO:0044297,GO:0044309,GO:0044325,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044430,GO:0044432,GO:0044444,GO:0044446,GO:0044449,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044557,GO:0044853,GO:0045121,GO:0045202,GO:0045211,GO:0045778,GO:0046677,GO:0046683,GO:0046872,GO:0046873,GO:0048167,GO:0048168,GO:0048172,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048522,GO:0048534,GO:0048568,GO:0048608,GO:0048709,GO:0048731,GO:0048738,GO:0048747,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050804,GO:0050806,GO:0050877,GO:0050880,GO:0050884,GO:0050890,GO:0050896,GO:0050905,GO:0051049,GO:0051094,GO:0051146,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051270,GO:0051272,GO:0051279,GO:0051282,GO:0051480,GO:0051481,GO:0051560,GO:0051591,GO:0051606,GO:0051641,GO:0051649,GO:0051716,GO:0051899,GO:0051924,GO:0055001,GO:0055002,GO:0055006,GO:0055007,GO:0055013,GO:0055065,GO:0055067,GO:0055074,GO:0055078,GO:0055080,GO:0055082,GO:0055085,GO:0055117,GO:0055119,GO:0060047,GO:0060048,GO:0060078,GO:0060291,GO:0060322,GO:0060341,GO:0060401,GO:0060402,GO:0060429,GO:0060537,GO:0061061,GO:0061337,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0070167,GO:0070169,GO:0070482,GO:0070509,GO:0070588,GO:0070838,GO:0070887,GO:0071310,GO:0071312,GO:0071313,GO:0071320,GO:0071407,GO:0071415,GO:0071417,GO:0071453,GO:0071456,GO:0071466,GO:0071495,GO:0071944,GO:0072359,GO:0072503,GO:0072507,GO:0072511,GO:0086001,GO:0086010,GO:0086012,GO:0086036,GO:0086038,GO:0086064,GO:0086065,GO:0090066,GO:0090075,GO:0090257,GO:0097060,GO:0097447,GO:0097458,GO:0097553,GO:0097746,GO:0097756,GO:0098588,GO:0098589,GO:0098590,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098703,GO:0098719,GO:0098735,GO:0098739,GO:0098771,GO:0098794,GO:0098805,GO:0098827,GO:0098857,GO:0099080,GO:0099081,GO:0099177,GO:0099512,GO:0099513,GO:0099516,GO:0099580,GO:0099587,GO:0120025,GO:0120038,GO:0140115,GO:1901660,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902656,GO:1903169,GO:1903522,GO:1903779,GO:1904062,GO:1990034,GO:2000026,GO:2000145,GO:2000147	-	ko:K05849	ko04020,ko04022,ko04371,ko04740,ko04974,map04020,map04022,map04371,map04740,map04974	-	-	-	ko00000,ko00001,ko00536,ko02000	2.A.19.3	-	-	Calx-beta,Na_Ca_ex,Na_Ca_ex_C
TLS3_k127_4740825_7	195105.CN97_00525	1.251e-33	132.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS3_k127_4740825_4	1547437.LL06_24465	6.494e-131	426.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2TR6P@28211|Alphaproteobacteria,43HFD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	futA1	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
TLS3_k127_4740825_0	1381123.AYOD01000003_gene1854	0.0	1204.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,43HWN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	tamB	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
TLS3_k127_4740825_2	1144343.PMI41_04002	1.049e-186	606.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2TRWD@28211|Alphaproteobacteria,43H99@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	surface antigen	tamA	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA
TLS3_k127_4740825_3	1446473.JHWH01000015_gene3606	3.7e-133	441.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2TQPI@28211|Alphaproteobacteria,2PVPX@265|Paracoccus	28211|Alphaproteobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS3_k127_4740825_6	1446473.JHWH01000009_gene231	5.248e-47	181.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2PY9Q@265|Paracoccus	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase2,HemolysinCabind
TLS3_k127_4740825_5	1192868.CAIU01000019_gene2707	1.241e-72	248.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,43JWA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS3_k127_4740825_1	1288298.rosmuc_00533	1.716e-314	967.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VFZH@28211|Alphaproteobacteria,46PQ0@74030|Roseovarius	28211|Alphaproteobacteria	H	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,HTH_24,PUA_2
TLS3_k127_4744011_2	1123229.AUBC01000003_gene2136	4.172e-45	168.0	COG0340@1|root,COG0340@2|Bacteria,1N1WU@1224|Proteobacteria,2TQK4@28211|Alphaproteobacteria,3JTCW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Biotin/lipoate A/B protein ligase family	-	-	-	-	-	-	-	-	-	-	-	-	BPL_LplA_LipB_2,DUF4444
TLS3_k127_4744011_1	1443111.JASG01000004_gene978	7.116e-54	203.0	28NIR@1|root,2ZBK2@2|Bacteria,1RAAF@1224|Proteobacteria,2U5XR@28211|Alphaproteobacteria,3ZX6Y@60136|Sulfitobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4744011_0	1411123.JQNH01000001_gene2302	8.676e-113	377.0	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2TTH2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4744011_3	1123229.AUBC01000003_gene2133	2.523e-33	146.0	COG0746@1|root,COG0746@2|Bacteria,1RB53@1224|Proteobacteria,2TUXF@28211|Alphaproteobacteria,3JT1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Protein of unknown function (DUF3305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3305
TLS3_k127_4744011_4	426355.Mrad2831_3200	3.758e-25	117.0	2AEGQ@1|root,314BX@2|Bacteria,1RD3G@1224|Proteobacteria,2U7I4@28211|Alphaproteobacteria,1JUUP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306
TLS3_k127_4767570_3	195105.CN97_09195	5.829e-158	524.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2TR3A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	deiminase	hutF	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS3_k127_4767570_2	1122614.JHZF01000017_gene2865	2.463e-165	552.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,2PDQ8@252301|Oceanicola	28211|Alphaproteobacteria	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS3_k127_4767570_0	384765.SIAM614_22497	4.634e-317	977.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS3_k127_4767570_1	314256.OG2516_12386	2.292e-187	592.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,2PCV0@252301|Oceanicola	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	MA20_36195	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
TLS3_k127_4767570_4	1131814.JAFO01000001_gene2019	3.756e-134	438.0	COG3832@1|root,COG3832@2|Bacteria,1N3W1@1224|Proteobacteria,2TSB4@28211|Alphaproteobacteria,3F0GM@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	MA20_35785	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_4767570_5	1131814.JAFO01000001_gene2020	2.212e-48	176.0	COG0640@1|root,COG0640@2|Bacteria,1N10H@1224|Proteobacteria,2UBRH@28211|Alphaproteobacteria,3F1H5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_4772450_0	1381123.AYOD01000001_gene1119	6.389e-261	818.0	COG0747@1|root,COG0747@2|Bacteria,1MUP8@1224|Proteobacteria,2TQXX@28211|Alphaproteobacteria,43KJB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	MA20_20695	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS3_k127_4772450_2	1121271.AUCM01000005_gene573	2.301e-150	487.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS3_k127_4772450_3	391593.RCCS2_02640	4.276e-149	486.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2P2KG@2433|Roseobacter	28211|Alphaproteobacteria	P	COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component	oppD1	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS3_k127_4772450_4	391613.RTM1035_04475	3.467e-118	397.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,46PD2@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_4772450_1	1411123.JQNH01000001_gene2590	1.073e-165	529.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amidohydrolase	MA20_09240	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_4772450_5	460265.Mnod_0829	7.231e-45	168.0	COG3832@1|root,COG3832@2|Bacteria,1RF9V@1224|Proteobacteria,2UA9G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_4787862_2	272943.RSP_1947	3.744e-93	312.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,1FAYT@1060|Rhodobacter	28211|Alphaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS3_k127_4787862_3	1122214.AQWH01000026_gene4804	1.135e-61	218.0	arCOG09452@1|root,335JP@2|Bacteria,1RJGH@1224|Proteobacteria,2UG21@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4787862_4	323098.Nwi_1835	1.373e-07	60.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,3JRGS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS3_k127_4787862_5	631454.N177_3563	1.737e-07	61.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,1JNKS@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS3_k127_4787862_1	316056.RPC_4421	1.034e-205	661.0	COG0492@1|root,COG2905@1|root,COG0492@2|Bacteria,COG2905@2|Bacteria,1MVX2@1224|Proteobacteria,2TQN3@28211|Alphaproteobacteria,3JU7C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cyclic nucleotide-monophosphate binding domain	MA20_21135	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,cNMP_binding
TLS3_k127_4787862_0	246200.SPO1431	3.463e-230	751.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria,4N9Y0@97050|Ruegeria	28211|Alphaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47,2.5.1.49	ko:K01738,ko:K01740	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R01287,R03601,R04859	RC00020,RC02814,RC02821,RC02848	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_4790127_1	1002340.AFCF01000042_gene2055	1.504e-101	358.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2TSU3@28211|Alphaproteobacteria,34E2Y@302485|Phaeobacter	28211|Alphaproteobacteria	S	Peptidase C26	puuD	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
TLS3_k127_4790127_0	272943.RSP_1982	1.008e-318	995.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,1FBEV@1060|Rhodobacter	28211|Alphaproteobacteria	E	TIGRFAM aminopeptidase N	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
TLS3_k127_4808242_4	652103.Rpdx1_3203	5.844e-28	115.0	COG1563@1|root,COG1563@2|Bacteria,1RB3N@1224|Proteobacteria,2UIUD@28211|Alphaproteobacteria,3JU5P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
TLS3_k127_4808242_3	935848.JAEN01000015_gene2494	4.224e-29	124.0	COG1006@1|root,COG1006@2|Bacteria,1N7TX@1224|Proteobacteria,2UHUU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM NADH-ubiquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS3_k127_4808242_1	1123229.AUBC01000012_gene2699	8.632e-159	520.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,3JSAF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS3_k127_4808242_0	1123229.AUBC01000012_gene2698	3.273e-201	662.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,3JX98@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
TLS3_k127_4808242_2	1123229.AUBC01000012_gene2697	2.958e-54	211.0	COG0651@1|root,COG0651@2|Bacteria,1N6BY@1224|Proteobacteria,2TUZY@28211|Alphaproteobacteria,3JXRH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS3_k127_4812529_5	388401.RB2150_17514	1.143e-87	297.0	COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2TR4M@28211|Alphaproteobacteria,3ZGQ7@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
TLS3_k127_4812529_1	1408418.JNJH01000011_gene3689	2.516e-112	368.0	COG1129@1|root,COG1129@2|Bacteria,1MW4I@1224|Proteobacteria,2VFEX@28211|Alphaproteobacteria,2JWD2@204441|Rhodospirillales	204441|Rhodospirillales	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_4812529_3	1121127.JAFA01000007_gene5325	3.853e-106	360.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2WAQR@28216|Betaproteobacteria,1K3VE@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_4812529_0	1121127.JAFA01000007_gene5326	3.164e-117	402.0	COG1879@1|root,COG1879@2|Bacteria,1MV17@1224|Proteobacteria,2W9DW@28216|Betaproteobacteria,1K6GW@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
TLS3_k127_4812529_4	935557.ATYB01000014_gene3374	2.006e-103	350.0	COG0583@1|root,COG0583@2|Bacteria,1MXDQ@1224|Proteobacteria,2U3ZA@28211|Alphaproteobacteria,4BAF8@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator, lysr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_4812529_6	1353531.AZNX01000003_gene2902	1.121e-77	274.0	COG1028@1|root,COG1028@2|Bacteria,1R5GY@1224|Proteobacteria,2UPHC@28211|Alphaproteobacteria,4BM5F@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_4812529_2	1122132.AQYH01000005_gene426	5.072e-108	357.0	COG0329@1|root,COG0329@2|Bacteria,1MWV5@1224|Proteobacteria,2TRE1@28211|Alphaproteobacteria,4BD3I@82115|Rhizobiaceae	28211|Alphaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS3_k127_4818580_0	1354722.JQLS01000008_gene1807	2.247e-175	557.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,46PU7@74030|Roseovarius	28211|Alphaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS3_k127_4819260_2	1157490.EL26_18565	2.368e-42	158.0	COG1247@1|root,COG1247@2|Bacteria,1VJ3A@1239|Firmicutes,4HRVQ@91061|Bacilli	91061|Bacilli	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_4819260_1	1122218.KB893654_gene1844	1.736e-170	541.0	COG2141@1|root,COG2141@2|Bacteria,1MUTJ@1224|Proteobacteria,2TTZI@28211|Alphaproteobacteria,1JU1Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_4819260_0	1417296.U879_18325	1.363e-204	644.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS3_k127_4884509_0	398580.Dshi_1282	0.0	1613.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Formate dehydrogenase, alpha subunit	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS3_k127_4884509_1	314256.OG2516_07477	4.513e-293	909.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,2PFAJ@252301|Oceanicola	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoEF	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
TLS3_k127_4884509_6	439497.RR11_1075	2.741e-91	310.0	COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2TQYX@28211|Alphaproteobacteria,4NA3U@97050|Ruegeria	28211|Alphaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_4884509_4	467661.RKLH11_3724	8.498e-136	451.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,3ZGY7@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_2,Ligase_CoA
TLS3_k127_4884509_5	467661.RKLH11_3270	3.215e-124	421.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,3ZH21@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	H	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,Ligase_CoA
TLS3_k127_4884509_3	314256.OG2516_14131	3.442e-145	468.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,2PCHS@252301|Oceanicola	28211|Alphaproteobacteria	E	Prephenate dehydrogenase	tyrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43	ko:K00210,ko:K00220,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025,M00040	R00732,R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS3_k127_4884509_2	1469613.JT55_13655	1.729e-147	475.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria,3FCK8@34008|Rhodovulum	28211|Alphaproteobacteria	E	Aminotransferase class I and II	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_4884509_7	1530186.JQEY01000001_gene893	5.602e-08	57.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS3_k127_4897723_2	1342302.JASC01000002_gene74	2.173e-106	368.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,2TTEF@28211|Alphaproteobacteria	1224|Proteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	MacB_PCD
TLS3_k127_4897723_5	290400.Jann_3107	2.336e-79	286.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_4897723_8	344747.PM8797T_24521	8.368e-18	96.0	2ECB1@1|root,3369C@2|Bacteria,2J4U8@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4897723_4	1342302.JASC01000002_gene77	1.717e-79	284.0	COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria,2UQPU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS3_k127_4897723_10	1305735.JAFT01000005_gene2270	2.243e-14	78.0	2DRE5@1|root,33BCF@2|Bacteria,1Q7EQ@1224|Proteobacteria,2UTK8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	ko:K16915	ko02010,map02010	M00246	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	-
TLS3_k127_4897723_11	575540.Isop_3247	3.65e-05	55.0	COG5266@1|root,COG5266@2|Bacteria,2J333@203682|Planctomycetes	203682|Planctomycetes	P	PFAM Nickel uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
TLS3_k127_4897723_9	1305735.JAFT01000005_gene2270	8.485e-18	92.0	2DRE5@1|root,33BCF@2|Bacteria,1Q7EQ@1224|Proteobacteria,2UTK8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	ko:K16915	ko02010,map02010	M00246	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	-
TLS3_k127_4897723_3	1121396.KB892902_gene2309	6.979e-105	349.0	COG5266@1|root,COG5266@2|Bacteria,1PVKN@1224|Proteobacteria,42PYV@68525|delta/epsilon subdivisions,2WK42@28221|Deltaproteobacteria,2MIRP@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Domain of unknown function (DUF4198)	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	DUF4198
TLS3_k127_4897723_1	1448389.BAVQ01000002_gene2942	2.215e-107	387.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS3_k127_4897723_0	706587.Desti_1959	9.6e-110	376.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,42M4U@68525|delta/epsilon subdivisions,2WJAG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K03458,ko:K16345	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.4.2	-	-	Xan_ur_permease
TLS3_k127_4897723_7	391613.RTM1035_12348	1.913e-22	100.0	COG5453@1|root,COG5453@2|Bacteria,1N7WA@1224|Proteobacteria,2UFN1@28211|Alphaproteobacteria,46R15@74030|Roseovarius	28211|Alphaproteobacteria	S	Transcriptional activator HlyU	hlyU	-	-	-	-	-	-	-	-	-	-	-	HlyU
TLS3_k127_4897723_6	1123072.AUDH01000013_gene1473	1.682e-61	214.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,2JQ4J@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS3_k127_4922985_4	388399.SSE37_21810	5.99e-09	60.0	COG0500@1|root,COG2226@2|Bacteria,1R6ZI@1224|Proteobacteria,2TRC6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_4922985_3	1123237.Salmuc_00758	1.004e-61	221.0	COG1116@1|root,COG1116@2|Bacteria,1MU6C@1224|Proteobacteria,2TS5F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS3_k127_4922985_2	744980.TRICHSKD4_0790	7.063e-90	306.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2TR0G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS3_k127_4922985_1	1461694.ATO9_14235	1.167e-130	427.0	COG0715@1|root,COG0715@2|Bacteria,1MWUA@1224|Proteobacteria,2TRS0@28211|Alphaproteobacteria,2PE5S@252301|Oceanicola	28211|Alphaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS3_k127_4922985_0	1231392.OCGS_1886	1.282e-252	788.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS3_k127_4946329_4	1121271.AUCM01000005_gene603	3.435e-06	55.0	COG3064@1|root,COG3064@2|Bacteria,1QVP8@1224|Proteobacteria,2TWJ5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4946329_1	252305.OB2597_15650	5.274e-58	207.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,2PE6J@252301|Oceanicola	28211|Alphaproteobacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS3_k127_4946329_0	1208323.B30_15716	1.825e-102	340.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2TQXQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	MotA TolQ ExbB proton channel	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
TLS3_k127_4946329_2	1380394.JADL01000003_gene5053	4.209e-36	141.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,2JTHP@204441|Rhodospirillales	204441|Rhodospirillales	S	thioesterase	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS3_k127_4946329_3	314278.NB231_12254	4.84e-29	117.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WX1Z@135613|Chromatiales	135613|Chromatiales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
TLS3_k127_4957064_2	1530186.JQEY01000001_gene697	3.657e-06	55.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS3_k127_4957064_0	1353528.DT23_17855	5.55e-278	876.0	COG3345@1|root,COG3345@2|Bacteria,1MWTQ@1224|Proteobacteria,2TR2X@28211|Alphaproteobacteria,2XP1T@285107|Thioclava	28211|Alphaproteobacteria	G	Melibiase	rafA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
TLS3_k127_4957064_1	1192868.CAIU01000010_gene1287	3.833e-181	587.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,43J1K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GMC oxidoreductase family	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_4964761_9	1188256.BASI01000001_gene1410	6.69e-50	197.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U7C6@28211|Alphaproteobacteria,3FDBG@34008|Rhodovulum	28211|Alphaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	chaC	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
TLS3_k127_4964761_8	1123360.thalar_00900	6.512e-73	257.0	COG4093@1|root,COG4093@2|Bacteria,1R5ZP@1224|Proteobacteria,2U3GC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2125)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2125
TLS3_k127_4964761_3	502025.Hoch_1341	1.598e-128	443.0	COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,42YS3@68525|delta/epsilon subdivisions,2WU59@28221|Deltaproteobacteria,2YTT1@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS3_k127_4964761_0	999550.KI421507_gene1369	7.144e-237	740.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
TLS3_k127_4964761_4	1294273.roselon_02804	1.461e-105	364.0	COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,2TT0A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
TLS3_k127_4964761_5	195105.CN97_10495	3.967e-101	335.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
TLS3_k127_4964761_2	1317124.DW2_12375	5.857e-137	445.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,2XM9V@285107|Thioclava	28211|Alphaproteobacteria	FP	Exopolyphosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS3_k127_4964761_6	314256.OG2516_06424	1.625e-100	336.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2PCRF@252301|Oceanicola	28211|Alphaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_4964761_11	999547.KI421500_gene1081	9.597e-38	149.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria,2UBTM@28211|Alphaproteobacteria,281R0@191028|Leisingera	28211|Alphaproteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
TLS3_k127_4964761_7	314265.R2601_25166	3.391e-98	330.0	COG0685@1|root,COG0685@2|Bacteria,1MVWT@1224|Proteobacteria,2TTSF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0685 5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_4964761_10	501479.ACNW01000076_gene1758	2.101e-48	192.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2U52Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_4964761_1	252305.OB2597_03524	1.898e-164	529.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TSBY@28211|Alphaproteobacteria,2PCDP@252301|Oceanicola	28211|Alphaproteobacteria	E	CO dehydrogenase/acetyl-CoA synthase delta subunit	acsE	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS3_k127_4972255_2	991905.SL003B_3825	2.886e-100	332.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,4BPSG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	MA20_16190	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
TLS3_k127_4972255_1	195105.CN97_01765	3.44e-105	349.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TRFC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
TLS3_k127_4972255_0	1530186.JQEY01000001_gene1269	4.779e-152	489.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS3_k127_4974598_2	1121271.AUCM01000008_gene3152	1.708e-41	158.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	thioesterase'	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
TLS3_k127_4974598_0	1121271.AUCM01000005_gene605	1.349e-98	329.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2TQXQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	MotA TolQ ExbB proton channel	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
TLS3_k127_4974598_1	1120983.KB894574_gene1024	4.446e-52	189.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,1JP2N@119043|Rhodobiaceae	28211|Alphaproteobacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
TLS3_k127_4980723_2	1122939.ATUD01000002_gene1260	6.247e-07	53.0	COG4293@1|root,COG4293@2|Bacteria,2IG98@201174|Actinobacteria,4CQEX@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF1802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
TLS3_k127_4980723_0	469383.Cwoe_1856	1.845e-217	685.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria	84995|Rubrobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS3_k127_4980723_1	469383.Cwoe_1857	2.528e-168	542.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS3_k127_4988416_3	314232.SKA53_10769	4.057e-36	152.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,2P7Y7@245186|Loktanella	28211|Alphaproteobacteria	BQ	Including yeast histone deacetylase and acetoin utilization protein	hdaH	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS3_k127_4988416_2	1510531.JQJJ01000009_gene1184	8.709e-49	180.0	COG2318@1|root,COG2318@2|Bacteria,1R974@1224|Proteobacteria,2U4ZA@28211|Alphaproteobacteria,3JQW4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
TLS3_k127_4988416_0	1188256.BASI01000002_gene3202	1.978e-221	714.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,3FCQZ@34008|Rhodovulum	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
TLS3_k127_4988416_1	1121272.KB903272_gene482	2.159e-94	318.0	COG2978@1|root,COG2978@2|Bacteria,2GN45@201174|Actinobacteria,4DH1N@85008|Micromonosporales	201174|Actinobacteria	H	AbgT putative transporter family	ydaH	-	-	ko:K12942	-	-	-	-	ko00000	-	-	-	ABG_transport
TLS3_k127_5001349_2	1525715.IX54_06110	2.433e-38	144.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,2PUEY@265|Paracoccus	28211|Alphaproteobacteria	G	in Escherichia coli this protein forms a dimer and binds manganese	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
TLS3_k127_5001349_0	1121271.AUCM01000005_gene900	1.183e-210	677.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Single-stranded-DNA-specific exonuclease (RecJ)	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS3_k127_5001349_1	246200.SPOA0210	2.426e-75	262.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,4NB15@97050|Ruegeria	28211|Alphaproteobacteria	EG	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
TLS3_k127_5001349_3	935261.JAGL01000029_gene342	9.228e-17	80.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2TT7F@28211|Alphaproteobacteria,43IWA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS3_k127_5013061_2	1380394.JADL01000008_gene3612	1.904e-28	124.0	COG0477@1|root,2Z82B@2|Bacteria,1R9GD@1224|Proteobacteria,2TTIS@28211|Alphaproteobacteria,2JVPW@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_5013061_0	1231392.OCGS_0283	3.96e-112	387.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0524 Sugar kinases, ribokinase family	pfkB	-	2.7.1.20,2.7.1.4	ko:K00847,ko:K00856	ko00051,ko00230,ko00500,ko00520,ko01100,map00051,map00230,map00500,map00520,map01100	-	R00185,R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS3_k127_5013061_1	1417296.U879_02420	1.679e-100	333.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS3_k127_5013061_3	69279.BG36_03780	1.442e-05	49.0	2EBP1@1|root,335P7@2|Bacteria,1NEQC@1224|Proteobacteria,2UN3R@28211|Alphaproteobacteria,43MAF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	PFAM Rickettsia 17 kDa surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,Rick_17kDa_Anti
TLS3_k127_5030622_3	1500301.JQMF01000023_gene5579	2.39e-46	179.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,4BAUP@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
TLS3_k127_5030622_1	1500301.JQMF01000023_gene5578	2.922e-100	336.0	COG0372@1|root,COG0372@2|Bacteria,1MUII@1224|Proteobacteria,2TSDI@28211|Alphaproteobacteria,4BD58@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_5030622_2	1500301.JQMF01000023_gene5577	9.015e-50	185.0	COG1802@1|root,COG1802@2|Bacteria,1N7GE@1224|Proteobacteria,2TRBH@28211|Alphaproteobacteria,4BCRM@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
TLS3_k127_5030622_0	314256.OG2516_11996	3.654e-136	439.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2TR82@28211|Alphaproteobacteria,2PC9Q@252301|Oceanicola	28211|Alphaproteobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25,4.1.99.12	ko:K01497,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
TLS3_k127_5032461_8	1288298.rosmuc_02302	3.124e-29	128.0	COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria,46QZJ@74030|Roseovarius	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DUF442
TLS3_k127_5032461_5	1123360.thalar_02036	1.658e-66	231.0	COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	grp	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS3_k127_5032461_2	1294273.roselon_02542	1.498e-159	516.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
TLS3_k127_5032461_10	1380380.JIAX01000010_gene144	1.21e-18	93.0	2CAHY@1|root,32RRF@2|Bacteria,1MZVR@1224|Proteobacteria,2UBQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2849)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2849
TLS3_k127_5032461_0	1380380.JIAX01000010_gene145	3.085e-271	847.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Sulfite reductase	cysI	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS3_k127_5032461_4	1121271.AUCM01000004_gene1257	3.298e-78	270.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2U5AP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF934,PAPS_reduct
TLS3_k127_5032461_9	349102.Rsph17025_0336	3.205e-27	124.0	COG3749@1|root,COG3749@2|Bacteria,1QV31@1224|Proteobacteria,2U9VA@28211|Alphaproteobacteria,1FC1V@1060|Rhodobacter	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
TLS3_k127_5032461_6	1185652.USDA257_c44300	2.121e-49	191.0	2DMYA@1|root,32UCU@2|Bacteria,1N37S@1224|Proteobacteria,2UCB7@28211|Alphaproteobacteria,4BN1W@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5032461_3	252305.OB2597_14043	2.205e-88	297.0	COG1738@1|root,COG1738@2|Bacteria,1MVQU@1224|Proteobacteria,2TRYN@28211|Alphaproteobacteria,2PDEW@252301|Oceanicola	28211|Alphaproteobacteria	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	yhhQ	GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046116,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072531,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1990397	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
TLS3_k127_5032461_7	1525715.IX54_07890	1.446e-42	165.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2U9M7@28211|Alphaproteobacteria,2PX0Y@265|Paracoccus	28211|Alphaproteobacteria	J	RF-1 domain	MA20_05665	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS3_k127_5032461_1	1089547.KB913013_gene3519	7.65e-174	561.0	2EXW3@1|root,33R57@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5034188_3	1123501.KB902288_gene1726	5.3e-24	100.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	3-hydroxyacyl-coa dehydrogenase	bhbD	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS3_k127_5034188_0	1122180.Lokhon_01380	1.803e-263	820.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2P8FE@245186|Loktanella	28211|Alphaproteobacteria	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
TLS3_k127_5034188_2	349102.Rsph17025_2563	1.045e-34	139.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,1FBZV@1060|Rhodobacter	28211|Alphaproteobacteria	H	HPr Serine kinase C-terminal domain	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C
TLS3_k127_5034188_1	1122180.Lokhon_01376	6.221e-75	258.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2TTI4@28211|Alphaproteobacteria,2P7XM@245186|Loktanella	28211|Alphaproteobacteria	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS3_k127_5049530_3	411684.HPDFL43_20282	4.349e-58	216.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,2TR3E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS3_k127_5049530_2	570967.JMLV01000006_gene199	9.023e-72	267.0	COG3016@1|root,COG3016@2|Bacteria,1NXYQ@1224|Proteobacteria,2U0QY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Iron-regulated protein	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
TLS3_k127_5049530_1	272943.RSP_0601	1.1e-122	402.0	COG0568@1|root,COG0568@2|Bacteria,1MUXA@1224|Proteobacteria,2TUED@28211|Alphaproteobacteria,1FB2E@1060|Rhodobacter	28211|Alphaproteobacteria	K	RNA polymerase, sigma 32 subunit, RpoH	rpoH2	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
TLS3_k127_5049530_0	1469613.JT55_15355	1.35e-232	730.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,3FCGC@34008|Rhodovulum	28211|Alphaproteobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS3_k127_5070337_2	252305.OB2597_07170	8.956e-71	242.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,2PD9N@252301|Oceanicola	28211|Alphaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS3_k127_5070337_0	1188256.BASI01000001_gene1333	3.154e-84	283.0	COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2TTCK@28211|Alphaproteobacteria,3FD3R@34008|Rhodovulum	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	lrp	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
TLS3_k127_5070337_1	272943.RSP_1576	5.226e-83	289.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,1FBDR@1060|Rhodobacter	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS3_k127_5101426_0	479434.Sthe_2247	4.929e-126	423.0	COG2909@1|root,COG2909@2|Bacteria,2G80F@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS3_k127_5115274_1	1317124.DW2_01190	4.516e-167	529.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2XMRG@285107|Thioclava	28211|Alphaproteobacteria	F	Belongs to the prokaryotic GSH synthase family	gshB	GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
TLS3_k127_5115274_5	1469613.JT55_15360	8.936e-69	246.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
TLS3_k127_5115274_2	1082933.MEA186_12026	1.838e-163	522.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,43N8V@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	MA20_17020	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS3_k127_5115274_3	1123072.AUDH01000001_gene3133	1.367e-131	429.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TTCJ@28211|Alphaproteobacteria,2JV7K@204441|Rhodospirillales	204441|Rhodospirillales	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
TLS3_k127_5115274_4	34007.IT40_20045	2.282e-77	271.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,2PVHC@265|Paracoccus	28211|Alphaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS3_k127_5115274_8	266809.PM03_12965	3.004e-08	65.0	COG3203@1|root,COG3203@2|Bacteria,1MX5Q@1224|Proteobacteria,2UA49@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Gram-negative porin	-	-	-	ko:K08720	ko01501,ko05111,map01501,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.1.2.1	-	-	Porin_4
TLS3_k127_5115274_7	266809.PM03_12965	1.082e-20	104.0	COG3203@1|root,COG3203@2|Bacteria,1MX5Q@1224|Proteobacteria,2UA49@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Gram-negative porin	-	-	-	ko:K08720	ko01501,ko05111,map01501,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.1.2.1	-	-	Porin_4
TLS3_k127_5115274_6	1294273.roselon_00852	9.755e-32	132.0	2C2J5@1|root,315UG@2|Bacteria,1RHAH@1224|Proteobacteria,2U94W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF3576)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3576
TLS3_k127_5115274_0	272943.RSP_0840	0.0	1058.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,1FAPS@1060|Rhodobacter	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS3_k127_5141007_0	1417296.U879_19765	3.777e-72	256.0	COG5590@1|root,COG5590@2|Bacteria,1MW25@1224|Proteobacteria,2U9ST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	rpsU-divergently transcribed protein	cOQ9	-	-	ko:K18587	-	-	-	-	ko00000	-	-	-	COQ9
TLS3_k127_5141007_3	1121271.AUCM01000011_gene1950	1.651e-27	112.0	COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
TLS3_k127_5141007_1	1348657.M622_16005	3.667e-64	224.0	COG2320@1|root,COG2320@2|Bacteria,1RH46@1224|Proteobacteria,2VWUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
TLS3_k127_5141007_2	412597.AEPN01000002_gene2772	4.783e-28	114.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria,2PVM0@265|Paracoccus	28211|Alphaproteobacteria	K	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS3_k127_5142105_1	1500257.JQNM01000004_gene254	1.182e-63	225.0	COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,2TUS4@28211|Alphaproteobacteria,4BEBI@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
TLS3_k127_5142105_2	69395.JQLZ01000006_gene2157	0.0008517	51.0	COG1585@1|root,COG1585@2|Bacteria,1PVR4@1224|Proteobacteria,2UEDQ@28211|Alphaproteobacteria,2KGY1@204458|Caulobacterales	204458|Caulobacterales	OU	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
TLS3_k127_5142105_0	1415756.JQMY01000001_gene3305	1.545e-116	397.0	COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,2TSX0@28211|Alphaproteobacteria,2PCP9@252301|Oceanicola	28211|Alphaproteobacteria	S	MotA TolQ ExbB proton channel family	MA20_18055	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
TLS3_k127_5153575_10	1008459.TASI_1188	1.318e-26	110.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,3T29C@506|Alcaligenaceae	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS3_k127_5153575_0	292414.TM1040_0010	0.0	1033.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,4NAJC@97050|Ruegeria	28211|Alphaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS3_k127_5153575_5	1461694.ATO9_00415	7.855e-82	288.0	COG3145@1|root,COG3145@2|Bacteria,1N5HB@1224|Proteobacteria,2U5C6@28211|Alphaproteobacteria,2PCRJ@252301|Oceanicola	28211|Alphaproteobacteria	L	2OG-Fe(II) oxygenase superfamily	alkB	-	1.14.11.33	ko:K03919	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	2OG-FeII_Oxy_2
TLS3_k127_5153575_4	1120983.KB894570_gene1861	6.634e-92	312.0	COG0412@1|root,COG0412@2|Bacteria,1R5J6@1224|Proteobacteria,2UE6V@28211|Alphaproteobacteria,1JP5P@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH,Peptidase_S9
TLS3_k127_5153575_9	1367847.JCM7686_0232	1.854e-28	125.0	COG3103@1|root,COG3650@1|root,COG3650@2|Bacteria,COG4991@2|Bacteria,1N281@1224|Proteobacteria,2UD1Y@28211|Alphaproteobacteria,2PUY9@265|Paracoccus	28211|Alphaproteobacteria	T	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS3_k127_5153575_8	1268635.Loa_02776	9.191e-43	162.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,1SA9N@1236|Gammaproteobacteria,1JEJ7@118969|Legionellales	118969|Legionellales	I	Thioesterase superfamily	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
TLS3_k127_5153575_2	1231392.OCGS_2530	5.547e-120	401.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	3'(2'),5'-bisphosphate nucleotidase	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
TLS3_k127_5153575_3	398580.Dshi_3575	3.411e-112	375.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
TLS3_k127_5153575_1	388401.RB2150_12466	1.05e-137	443.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2TRT6@28211|Alphaproteobacteria,3ZG1I@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	M	UTP--glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS3_k127_5153575_7	1469613.JT55_00725	2.647e-51	186.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,3FDBV@34008|Rhodovulum	28211|Alphaproteobacteria	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
TLS3_k127_5153575_6	1415756.JQMY01000001_gene585	1.926e-77	263.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,2PCKG@252301|Oceanicola	28211|Alphaproteobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS3_k127_5166230_5	1294273.roselon_00309	6.103e-42	159.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	MA20_17975	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TLS3_k127_5166230_2	935848.JAEN01000005_gene3699	3.545e-126	409.0	COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria,2PVT8@265|Paracoccus	28211|Alphaproteobacteria	S	YmdB-like protein	MA20_17970	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
TLS3_k127_5166230_4	290400.Jann_3384	3.525e-75	268.0	COG0697@1|root,COG0697@2|Bacteria,1PDMU@1224|Proteobacteria,2U0T9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_5166230_1	349102.Rsph17025_0576	3.969e-188	607.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,1FBIB@1060|Rhodobacter	28211|Alphaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS3_k127_5166230_0	391613.RTM1035_15632	7.365e-226	715.0	COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,46PE6@74030|Roseovarius	28211|Alphaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS3_k127_5166230_3	1449351.RISW2_02325	1.084e-124	404.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,4KM01@93682|Roseivivax	28211|Alphaproteobacteria	K	transcriptional regulatory protein	MA20_17930	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS3_k127_5174631_1	1415756.JQMY01000001_gene2162	1.805e-179	576.0	COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,2PCZV@252301|Oceanicola	28211|Alphaproteobacteria	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
TLS3_k127_5174631_2	1122614.JHZF01000011_gene929	4.421e-169	540.0	COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,2PCRD@252301|Oceanicola	28211|Alphaproteobacteria	S	Phage portal protein	gp34	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
TLS3_k127_5174631_4	1121271.AUCM01000001_gene3375	3.107e-17	93.0	2E4PR@1|root,32ZID@2|Bacteria,1N6SB@1224|Proteobacteria,2UFAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5174631_3	1415756.JQMY01000001_gene2165	1.684e-60	218.0	COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,2PE85@252301|Oceanicola	28211|Alphaproteobacteria	S	Caudovirus prohead serine protease	-	-	-	ko:K06904	-	-	-	-	ko00000	-	-	-	Peptidase_S78
TLS3_k127_5174631_0	1469613.JT55_04015	3.763e-186	591.0	COG4653@1|root,COG4653@2|Bacteria,1MWU1@1224|Proteobacteria,2TSSY@28211|Alphaproteobacteria,3FCG9@34008|Rhodovulum	28211|Alphaproteobacteria	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
TLS3_k127_5181030_2	1305735.JAFT01000005_gene501	4.776e-42	171.0	COG0697@1|root,COG0697@2|Bacteria,1R3W3@1224|Proteobacteria,2TS0I@28211|Alphaproteobacteria,2PE8F@252301|Oceanicola	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_5181030_0	1333998.M2A_2936	4.869e-160	522.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,4BPA9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS3_k127_5181030_1	1370122.JHXQ01000010_gene1445	8.345e-96	317.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,4B8BZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS3_k127_5206411_4	1126627.BAWE01000002_gene1265	3.832e-71	244.0	COG1309@1|root,COG1309@2|Bacteria,1RC7C@1224|Proteobacteria,2U5YR@28211|Alphaproteobacteria,3JXEE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_5206411_1	1380391.JIAS01000012_gene4529	5.461e-91	308.0	COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,2U3BR@28211|Alphaproteobacteria,2JVJT@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS3_k127_5206411_2	1510531.JQJJ01000008_gene3671	3.761e-90	310.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,3JSM5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FMN-dependent dehydrogenase	lldD	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
TLS3_k127_5206411_3	1380391.JIAS01000012_gene4531	4.178e-72	251.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria,2JSXD@204441|Rhodospirillales	204441|Rhodospirillales	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
TLS3_k127_5206411_0	1089551.KE386572_gene848	1.679e-120	396.0	COG1172@1|root,COG1172@2|Bacteria,1PRXF@1224|Proteobacteria,2TV5I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS3_k127_5206411_5	1528106.JRJE01000025_gene87	1.892e-07	52.0	COG1172@1|root,COG1172@2|Bacteria,1MVKQ@1224|Proteobacteria,2TTT3@28211|Alphaproteobacteria,2JPKQ@204441|Rhodospirillales	204441|Rhodospirillales	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS3_k127_5211697_2	1245471.PCA10_29550	9.605e-15	77.0	2EP82@1|root,33GUS@2|Bacteria,1NHPI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5211697_0	272943.RSP_0946	5.433e-143	461.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,2TUAH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA topoisomerase	MA20_25110	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
TLS3_k127_5211697_1	272943.RSP_2384	3.454e-63	226.0	COG3871@1|root,COG3871@2|Bacteria,1RJZK@1224|Proteobacteria,2U9BJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	stress protein (general stress protein 26)	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
TLS3_k127_5233157_2	1469613.JT55_08980	1.532e-78	267.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,3FD10@34008|Rhodovulum	28211|Alphaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS3_k127_5233157_3	1449350.OCH239_01020	1.26e-76	259.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,4KKBG@93682|Roseivivax	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS3_k127_5233157_1	1121028.ARQE01000028_gene303	6.56e-85	297.0	COG5001@1|root,COG5001@2|Bacteria,1QU1Y@1224|Proteobacteria,2U5YN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF
TLS3_k127_5233157_0	1461694.ATO9_20060	3.139e-141	471.0	COG3898@1|root,COG3898@2|Bacteria,1P5RR@1224|Proteobacteria,2TT5Q@28211|Alphaproteobacteria,2PCD5@252301|Oceanicola	28211|Alphaproteobacteria	S	HemY protein N-terminus	lapB	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_19
TLS3_k127_5233157_4	1294273.roselon_01374	1.568e-22	111.0	COG4223@1|root,COG4223@2|Bacteria,1RHEC@1224|Proteobacteria,2UAF8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	Mitofilin
TLS3_k127_5272467_2	1353528.DT23_04855	2.11e-135	439.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2XKNB@285107|Thioclava	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
TLS3_k127_5272467_5	1266908.AQPB01000039_gene832	1.102e-84	289.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_5272467_0	1188256.BASI01000007_gene2247	4.69e-204	649.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,3FCWU@34008|Rhodovulum	28211|Alphaproteobacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS3_k127_5272467_7	195105.CN97_02875	1.657e-15	79.0	COG1585@1|root,COG1585@2|Bacteria,1NA05@1224|Proteobacteria,2UFXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	COG1585 Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS3_k127_5272467_3	195105.CN97_02870	5.92e-134	432.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
TLS3_k127_5272467_1	1121271.AUCM01000006_gene404	1.856e-158	511.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C
TLS3_k127_5272467_4	391619.PGA1_c32480	9.301e-97	325.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,34FBJ@302485|Phaeobacter	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	MA20_06380	-	3.5.1.68	ko:K01458	ko00340,ko00630,map00340,map00630	-	R00525	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	FGase
TLS3_k127_5272467_8	766499.C357_20375	8.112e-15	78.0	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS3_k127_5272467_6	318586.Pden_0390	8.044e-16	78.0	COG5349@1|root,COG5349@2|Bacteria,1PSFX@1224|Proteobacteria,2V4MW@28211|Alphaproteobacteria,2PXF3@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
TLS3_k127_5288249_0	1547437.LL06_00605	0.0	1379.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43IYD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
TLS3_k127_5288249_1	1279038.KB907347_gene3143	2.269e-90	305.0	COG0657@1|root,COG0657@2|Bacteria,1MV3J@1224|Proteobacteria,2TUQ3@28211|Alphaproteobacteria,2JSFA@204441|Rhodospirillales	204441|Rhodospirillales	I	alpha/beta hydrolase fold	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3,Abhydrolase_6
TLS3_k127_5288249_2	349102.Rsph17025_3011	1.854e-32	130.0	COG1522@1|root,COG1522@2|Bacteria,1MZDV@1224|Proteobacteria,2UBTU@28211|Alphaproteobacteria,1FBZG@1060|Rhodobacter	28211|Alphaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	QU41_18010	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
TLS3_k127_5301223_5	195105.CN97_05705	2.091e-36	142.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS3_k127_5301223_4	1231392.OCGS_0362	1.229e-43	165.0	COG5342@1|root,COG5342@2|Bacteria,1R46Z@1224|Proteobacteria,2U5KW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	invasion associated locus B	-	-	-	-	-	-	-	-	-	-	-	-	IalB
TLS3_k127_5301223_3	391626.OAN307_c46020	1.508e-45	173.0	COG1595@1|root,COG1595@2|Bacteria,1RHRR@1224|Proteobacteria,2U9G0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_5301223_0	376733.IT41_16980	2.514e-128	419.0	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2TV9J@28211|Alphaproteobacteria,2PW5H@265|Paracoccus	28211|Alphaproteobacteria	E	L-asparaginase II	ansA	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
TLS3_k127_5301223_7	335543.Sfum_1184	3.046e-05	49.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5301223_1	1449350.OCH239_18580	2.545e-83	295.0	COG3710@1|root,COG5616@1|root,COG3710@2|Bacteria,COG5616@2|Bacteria,1R8J1@1224|Proteobacteria,2U521@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS3_k127_5301223_6	1569209.BBPH01000080_gene108	1.541e-13	78.0	2DNVR@1|root,32ZDF@2|Bacteria,1PMNT@1224|Proteobacteria,2V08X@28211|Alphaproteobacteria,2PY0J@265|Paracoccus	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5301223_2	999547.KI421500_gene2362	3.579e-57	200.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,27ZGE@191028|Leisingera	28211|Alphaproteobacteria	E	Aconitase family (aconitate hydratase)	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS3_k127_5320554_7	222534.KB893683_gene1215	7.49e-13	76.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4ERVU@85013|Frankiales	201174|Actinobacteria	F	PFAM Adenosine AMP deaminase	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
TLS3_k127_5320554_5	472759.Nhal_3082	9.785e-19	96.0	COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,1T04E@1236|Gammaproteobacteria,1X2KR@135613|Chromatiales	135613|Chromatiales	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS3_k127_5320554_3	1123247.AUIJ01000019_gene22	5.041e-63	220.0	COG0741@1|root,COG0741@2|Bacteria,1N08U@1224|Proteobacteria,2U82R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS3_k127_5320554_4	864069.MicloDRAFT_00044120	3.08e-51	188.0	COG3247@1|root,COG3247@2|Bacteria,1R63F@1224|Proteobacteria,2U3AR@28211|Alphaproteobacteria,1JYSN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	MA20_30435	-	-	-	-	-	-	-	-	-	-	-	DUF308
TLS3_k127_5320554_0	1305735.JAFT01000005_gene3719	0.0	1471.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2PCDX@252301|Oceanicola	28211|Alphaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
TLS3_k127_5320554_2	1354722.JQLS01000008_gene1196	4.122e-134	433.0	COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,2TRAX@28211|Alphaproteobacteria,46P66@74030|Roseovarius	28211|Alphaproteobacteria	K	Transcriptional regulator, LysR family	MA20_05050	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_5320554_1	272943.RSP_2951	0.0	1043.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,1FB44@1060|Rhodobacter	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS3_k127_5325447_1	1305735.JAFT01000005_gene2063	6.023e-126	419.0	COG1594@1|root,COG1594@2|Bacteria,1MWK8@1224|Proteobacteria,2U0YM@28211|Alphaproteobacteria,2PCFP@252301|Oceanicola	28211|Alphaproteobacteria	K	COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase	-	-	-	-	-	-	-	-	-	-	-	-	zf-RRN7
TLS3_k127_5325447_0	1461694.ATO9_06090	1.307e-164	528.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2TRUP@28211|Alphaproteobacteria,2PCB2@252301|Oceanicola	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4339)	ydjI	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,SHOCT
TLS3_k127_5325447_2	1317124.DW2_04675	4.254e-37	143.0	2BWZZ@1|root,2Z86E@2|Bacteria,1MW89@1224|Proteobacteria,2U08W@28211|Alphaproteobacteria,2XMKM@285107|Thioclava	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2927)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2927
TLS3_k127_5339556_1	1082931.KKY_3138	6.239e-141	460.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2TSIP@28211|Alphaproteobacteria,3N6FZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS3_k127_5339556_0	1211112.ALJC01000122_gene314	9.791e-212	672.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS3_k127_5339556_2	686340.Metal_3865	4.963e-41	156.0	COG4636@1|root,COG4636@2|Bacteria,1RGFC@1224|Proteobacteria,1S3SY@1236|Gammaproteobacteria,1XGBA@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_5352801_0	1122218.KB893653_gene1064	1.188e-87	294.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,1JSTK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS3_k127_5352801_1	501479.ACNW01000065_gene3280	4.783e-43	162.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_39715	-	-	-	-	-	-	-	-	-	-	-	DUF1178
TLS3_k127_5352801_2	1089552.KI911559_gene524	1.246e-38	155.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,2JQBI@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
TLS3_k127_5363991_3	272942.RCAP_rcc02308	1.443e-96	325.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,2TV8D@28211|Alphaproteobacteria,1FBXD@1060|Rhodobacter	28211|Alphaproteobacteria	S	EamA-like transporter family	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
TLS3_k127_5363991_4	1123360.thalar_01115	1.971e-90	308.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	integral membrane protein	MA20_41380	-	-	-	-	-	-	-	-	-	-	-	DUF2189
TLS3_k127_5363991_2	1317124.DW2_02335	3.273e-115	389.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,2XM8T@285107|Thioclava	28211|Alphaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
TLS3_k127_5363991_1	314256.OG2516_11481	1.273e-123	417.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,2PD1D@252301|Oceanicola	28211|Alphaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
TLS3_k127_5363991_0	246200.SPO0066	3.726e-140	462.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2TS53@28211|Alphaproteobacteria,4N9ZH@97050|Ruegeria	28211|Alphaproteobacteria	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
TLS3_k127_5363991_5	795797.C497_15842	1.164e-05	54.0	COG0726@1|root,arCOG02876@2157|Archaea,2XWD9@28890|Euryarchaeota,23U0Q@183963|Halobacteria	183963|Halobacteria	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
TLS3_k127_5422041_1	1305735.JAFT01000005_gene3846	7.569e-80	270.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,2PDN6@252301|Oceanicola	28211|Alphaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
TLS3_k127_5422041_0	272942.RCAP_rcc01911	2.197e-143	471.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,1FBFM@1060|Rhodobacter	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS3_k127_5422041_2	246200.SPO2495	1.47e-47	172.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,4NCCY@97050|Ruegeria	28211|Alphaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS3_k127_5422041_3	1417296.U879_13035	1.48e-40	152.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2U9A5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, MerR family	merR	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS3_k127_544752_2	338966.Ppro_1373	4.606e-22	108.0	COG5544@1|root,COG5544@2|Bacteria,1QU58@1224|Proteobacteria,42S6G@68525|delta/epsilon subdivisions,2WNWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_544752_1	1123229.AUBC01000016_gene4266	7.169e-43	162.0	2CGGQ@1|root,32S3Z@2|Bacteria,1MZDW@1224|Proteobacteria,2UD1K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Protein of unknown function (DUF3140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3140
TLS3_k127_544752_0	252305.OB2597_08924	4.342e-67	243.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind,Peptidase_M10_C
TLS3_k127_5457541_2	89187.ISM_13260	5.306e-41	156.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TTQ4@28211|Alphaproteobacteria,46ND9@74030|Roseovarius	28211|Alphaproteobacteria	E	COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
TLS3_k127_5457541_1	371731.Rsw2DRAFT_0966	2.975e-84	293.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria,1FBC4@1060|Rhodobacter	28211|Alphaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS3_k127_5457541_0	349102.Rsph17025_3087	6.191e-227	711.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,1FBJ4@1060|Rhodobacter	28211|Alphaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
TLS3_k127_5463994_3	1461694.ATO9_08565	3.561e-32	126.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,2TQNS@28211|Alphaproteobacteria,2PDB2@252301|Oceanicola	28211|Alphaproteobacteria	EG	Belongs to the IlvD Edd family	edd	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS3_k127_5463994_1	375451.RD1_2878	1.346e-88	301.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,2P2E9@2433|Roseobacter	28211|Alphaproteobacteria	G	COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase	eda	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
TLS3_k127_5463994_0	1122132.AQYH01000010_gene4110	8.561e-213	684.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,4B7E4@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the GPI family	pgi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS3_k127_5463994_4	1207063.P24_09516	2.06e-24	114.0	COG0589@1|root,COG0589@2|Bacteria,1MZVB@1224|Proteobacteria,2UIF6@28211|Alphaproteobacteria,2JXQG@204441|Rhodospirillales	204441|Rhodospirillales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_5463994_2	991905.SL003B_0879	2.029e-65	232.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,2TQYW@28211|Alphaproteobacteria,4BQ0J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	RNA pseudouridylate synthase	rluA	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
TLS3_k127_5463994_5	450851.PHZ_c1346	7.625e-07	51.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,2KI3K@204458|Caulobacterales	204458|Caulobacterales	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
TLS3_k127_5471794_1	1288298.rosmuc_01417	7.434e-207	649.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,46NZP@74030|Roseovarius	28211|Alphaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
TLS3_k127_5471794_4	89187.ISM_10685	1.904e-119	405.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,46Q1G@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0626 Cystathionine beta-lyases cystathionine gamma-synthases	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_5471794_2	1449351.RISW2_15145	9.209e-145	490.0	COG2124@1|root,COG2124@2|Bacteria,1PHZM@1224|Proteobacteria,2V863@28211|Alphaproteobacteria,4KP4T@93682|Roseivivax	28211|Alphaproteobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_5471794_6	1522072.IL54_1822	6.377e-103	340.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2TRGG@28211|Alphaproteobacteria,2K1ZT@204457|Sphingomonadales	204457|Sphingomonadales	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
TLS3_k127_5471794_3	1449351.RISW2_07670	2.149e-144	467.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,4KKRI@93682|Roseivivax	28211|Alphaproteobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_5471794_5	1569209.BBPH01000069_gene3966	1.685e-105	359.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2PUTC@265|Paracoccus	28211|Alphaproteobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS3_k127_5471794_9	1122180.Lokhon_00954	2.401e-26	127.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,2P975@245186|Loktanella	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	bigR	-	-	-	-	-	-	-	-	-	-	-	HTH_5
TLS3_k127_5471794_0	279714.FuraDRAFT_3015	0.0	1165.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KQDF@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdE	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
TLS3_k127_5471794_8	1469613.JT55_13615	1.124e-40	174.0	COG5458@1|root,COG5458@2|Bacteria,1N054@1224|Proteobacteria,2UBY1@28211|Alphaproteobacteria,3FDEQ@34008|Rhodovulum	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1489)	MA20_36070	-	-	-	-	-	-	-	-	-	-	-	DUF1489
TLS3_k127_5471794_7	1123247.AUIJ01000010_gene158	2.482e-71	252.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS3_k127_5478202_0	935261.JAGL01000011_gene2058	8.161e-254	803.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,43INN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
TLS3_k127_5478202_2	1417296.U879_08655	7.277e-86	307.0	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS3_k127_5478202_1	272943.RSP_2183	2.047e-200	632.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,1FB9C@1060|Rhodobacter	28211|Alphaproteobacteria	C	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid	betB	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_5527134_2	1121939.L861_14940	2.953e-31	130.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS3_k127_5527134_1	1353537.TP2_04710	2.809e-83	291.0	29WNZ@1|root,30I9V@2|Bacteria,1RD7D@1224|Proteobacteria,2U7N7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5527134_0	314271.RB2654_12629	5.897e-86	290.0	COG2223@1|root,COG2223@2|Bacteria,1QV5K@1224|Proteobacteria,2TWA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_5527575_0	224911.27355196	3.395e-138	462.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2V8CX@28211|Alphaproteobacteria,3K1IY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_5527575_2	1458357.BG58_08765	6.039e-69	243.0	COG1082@1|root,COG1082@2|Bacteria,1R3UQ@1224|Proteobacteria,2VKWW@28216|Betaproteobacteria,1K547@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS3_k127_5527575_1	658612.MD26_21295	3.892e-106	351.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,1S20H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS3_k127_5527693_1	1472418.BBJC01000001_gene804	4.485e-15	86.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	divL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,PAS_8
TLS3_k127_5527693_0	1122614.JHZF01000013_gene3273	1.561e-44	168.0	COG0642@1|root,COG2205@2|Bacteria,1QV2U@1224|Proteobacteria,2TW9G@28211|Alphaproteobacteria,2PDR1@252301|Oceanicola	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	regB	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS3_k127_5530469_0	501479.ACNW01000066_gene3262	4.225e-139	445.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS3_k127_5530469_5	58123.JOFJ01000007_gene531	4.323e-43	162.0	COG2518@1|root,COG2518@2|Bacteria,2IKSJ@201174|Actinobacteria,4EQ8F@85012|Streptosporangiales	201174|Actinobacteria	O	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_5530469_2	391593.RCCS2_03344	4.169e-112	369.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,2P1BE@2433|Roseobacter	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
TLS3_k127_5530469_4	388401.RB2150_05328	1.365e-54	198.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria,3ZHAJ@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
TLS3_k127_5530469_3	1449350.OCH239_01240	7.135e-80	295.0	COG2931@1|root,COG3119@1|root,COG2931@2|Bacteria,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,4KKB9@93682|Roseivivax	28211|Alphaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,HemolysinCabind,Sulfatase
TLS3_k127_5530469_1	1500257.JQNM01000006_gene1918	5.105e-114	376.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,4B7D7@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glycine cleavage system T protein	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS3_k127_5552494_4	1318628.MARLIPOL_09851	4.487e-23	108.0	2BY09@1|root,3353N@2|Bacteria,1NFWE@1224|Proteobacteria,1SR07@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS3_k127_5552494_2	313612.L8106_14650	1.066e-32	139.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,1G4UZ@1117|Cyanobacteria,1HAAV@1150|Oscillatoriales	1117|Cyanobacteria	Q	Scp-like extracellular	-	-	-	-	-	-	-	-	-	-	-	-	CAP,HemolysinCabind,PPC
TLS3_k127_5552494_3	1541065.JRFE01000014_gene1630	1.879e-29	129.0	COG2340@1|root,COG2340@2|Bacteria,1G4UZ@1117|Cyanobacteria,3VKJX@52604|Pleurocapsales	1117|Cyanobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,HemolysinCabind,PPC
TLS3_k127_5552494_0	1246459.KB898371_gene38	0.0	1013.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,4B8GI@82115|Rhizobiaceae	28211|Alphaproteobacteria	EG	Belongs to the IlvD Edd family	MA20_27195	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS3_k127_5552494_1	1120999.JONM01000014_gene2822	6.428e-35	145.0	COG0406@1|root,COG0406@2|Bacteria,1RH8P@1224|Proteobacteria,2VUH5@28216|Betaproteobacteria	28216|Betaproteobacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5564645_1	1123501.KB902276_gene1190	6.725e-43	172.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
TLS3_k127_5564645_0	1417296.U879_07420	1.137e-271	859.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
TLS3_k127_5594543_3	1297570.MESS4_750003	2.525e-06	49.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1NJ6Q@1224|Proteobacteria,2U3XV@28211|Alphaproteobacteria,43RF1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS3_k127_5594543_0	266834.SM_b20686	3.255e-138	443.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2TRTI@28211|Alphaproteobacteria,4BCZS@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS3_k127_5594543_1	1041159.AZUW01000016_gene1583	1.324e-106	360.0	COG0457@1|root,COG0457@2|Bacteria,1PQD2@1224|Proteobacteria,2U31T@28211|Alphaproteobacteria,4BD55@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_17,TPR_19,TPR_2,TPR_4,TPR_8
TLS3_k127_5594543_2	1057002.KB905370_gene3917	1.873e-74	253.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,4B8PH@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Thioesterase
TLS3_k127_5609190_1	367336.OM2255_03287	1.027e-105	348.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS3_k127_5609190_0	1123247.AUIJ01000009_gene3089	2.65e-135	450.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS3_k127_5609190_2	398580.Dshi_1801	2.743e-62	221.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS3_k127_5609190_3	1337093.MBE-LCI_1460	7.984e-28	113.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,2P8NJ@245186|Loktanella	28211|Alphaproteobacteria	E	Indole-3-glycerol phosphate synthase	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS3_k127_5616271_1	1123360.thalar_03196	1.872e-53	189.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_5616271_0	398580.Dshi_3491	6.649e-231	730.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	abcT3	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_5625362_5	266809.PM03_12460	7.232e-32	125.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS3_k127_5625362_1	1446473.JHWH01000002_gene1635	1.877e-107	362.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,2PVUY@265|Paracoccus	28211|Alphaproteobacteria	M	Penicillin-binding protein 5, C-terminal domain	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
TLS3_k127_5625362_2	1120949.KB903301_gene6412	1.623e-98	328.0	COG1028@1|root,COG1028@2|Bacteria,2IB1P@201174|Actinobacteria,4DE41@85008|Micromonosporales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_5625362_3	1500259.JQLD01000022_gene1604	7.168e-65	224.0	COG3832@1|root,COG3832@2|Bacteria,1NAJ0@1224|Proteobacteria,2UFZ0@28211|Alphaproteobacteria,4BERQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_5625362_4	1500259.JQLD01000022_gene1603	6.884e-45	164.0	COG0640@1|root,COG0640@2|Bacteria,1RIW5@1224|Proteobacteria,2UB7R@28211|Alphaproteobacteria,4BFPT@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_5625362_0	272943.RSP_1205	4.278e-130	428.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,1FBGB@1060|Rhodobacter	28211|Alphaproteobacteria	H	Probable RNA and SrmB- binding site of polymerase A	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
TLS3_k127_5625362_6	1122180.Lokhon_00732	5.085e-14	72.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2P903@245186|Loktanella	28211|Alphaproteobacteria	L	NUDIX domain	MA20_44635	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_5630579_4	1208323.B30_12739	7.588e-07	51.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	type II secretion system protein	tadC	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS3_k127_5630579_1	1402135.SUH3_17335	1.542e-52	195.0	COG5010@1|root,COG5010@2|Bacteria,1MVTK@1224|Proteobacteria,2TVBA@28211|Alphaproteobacteria,3ZYUE@60136|Sulfitobacter	28211|Alphaproteobacteria	U	Tetratricopeptide repeat	MA20_18455	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_12,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
TLS3_k127_5630579_2	392499.Swit_4870	4.482e-12	77.0	COG4960@1|root,COG4960@2|Bacteria,1RAYG@1224|Proteobacteria,2UJT9@28211|Alphaproteobacteria,2K6EK@204457|Sphingomonadales	204457|Sphingomonadales	OU	peptidase	cpaA	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
TLS3_k127_5630579_0	195105.CN97_12860	3.142e-106	353.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
TLS3_k127_5630913_1	1131813.AQVT01000001_gene3803	4.205e-89	310.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,1JTP5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS_3,PAS_4,PAS_7,PAS_8
TLS3_k127_5630913_0	400682.PAC_15710424	3.365e-124	409.0	COG0626@1|root,KOG0053@2759|Eukaryota,3A170@33154|Opisthokonta,3BQFC@33208|Metazoa	33208|Metazoa	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
TLS3_k127_5630913_2	1417296.U879_04190	4.986e-88	302.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	cytochrome P450	pksS	-	1.14.14.1	ko:K00493	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko01000	-	-	-	p450
TLS3_k127_5649371_0	1417296.U879_09120	6.279e-170	553.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS3_k127_5649371_1	252305.OB2597_08694	4.637e-43	162.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2PD9U@252301|Oceanicola	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS3_k127_5681343_0	1188256.BASI01000002_gene3449	2.092e-291	901.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,3FD97@34008|Rhodovulum	28211|Alphaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
TLS3_k127_5681343_4	272943.RSP_1674	1.743e-117	384.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,1FB07@1060|Rhodobacter	28211|Alphaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS3_k127_5681343_7	1530186.JQEY01000002_gene1713	5.03e-72	262.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS3_k127_5681343_3	1188256.BASI01000001_gene634	1.512e-146	482.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,3FCH5@34008|Rhodovulum	28211|Alphaproteobacteria	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS3_k127_5681343_8	1469613.JT55_15895	1.689e-45	174.0	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UCBQ@28211|Alphaproteobacteria,3FDG1@34008|Rhodovulum	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1491)	MA20_15690	-	-	-	-	-	-	-	-	-	-	-	DUF1491
TLS3_k127_5681343_1	1166948.JPZL01000002_gene1517	1.032e-264	834.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,1XIM5@135619|Oceanospirillales	135619|Oceanospirillales	P	anion transporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS3_k127_5681343_6	1188256.BASI01000001_gene519	4.634e-74	256.0	COG1381@1|root,COG1381@2|Bacteria,1MVEJ@1224|Proteobacteria,2TTYW@28211|Alphaproteobacteria,3FD5H@34008|Rhodovulum	28211|Alphaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS3_k127_5681343_5	266835.14028276	4.527e-97	336.0	COG3920@1|root,COG3920@2|Bacteria,1MXWD@1224|Proteobacteria,2TUVS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,PAS_4,PAS_8,PAS_9
TLS3_k127_5681343_10	371731.Rsw2DRAFT_1703	3.285e-20	96.0	COG3187@1|root,COG3187@2|Bacteria,1N0S0@1224|Proteobacteria,2UBSA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG3187 Heat shock protein	-	-	-	-	-	-	-	-	-	-	-	-	META
TLS3_k127_5681343_2	1122218.KB893654_gene1938	6.351e-243	762.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,1JRPH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase type 2 domain	mcd	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_5682482_1	1342301.JASD01000008_gene989	2.65e-57	201.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,3ZVI2@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS3_k127_5682482_0	991905.SL003B_1516	1.553e-138	452.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,4BTE3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_5682482_2	1122609.AUGT01000012_gene4394	7.478e-28	124.0	2B5JQ@1|root,31YEN@2|Bacteria,2GXVE@201174|Actinobacteria	201174|Actinobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS3_k127_5686429_1	1472418.BBJC01000002_gene1321	2.131e-72	249.0	COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GcrA cell cycle regulator	gcrA	-	-	ko:K13583	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	GcrA
TLS3_k127_5686429_0	1469613.JT55_07275	1.613e-140	451.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,3FCX2@34008|Rhodovulum	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS3_k127_5686429_2	1294273.roselon_01252	3.071e-53	198.0	COG0454@1|root,COG0454@2|Bacteria,1RDGT@1224|Proteobacteria,2TRF5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS3_k127_5686429_3	1287276.X752_15400	4.256e-14	73.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2TS9C@28211|Alphaproteobacteria,43NQN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Aminotransferase	tyrB	-	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_5686834_1	1469613.JT55_04060	6.677e-88	308.0	COG5449@1|root,COG5449@2|Bacteria,1MXK2@1224|Proteobacteria,2TTWS@28211|Alphaproteobacteria,3FD28@34008|Rhodovulum	28211|Alphaproteobacteria	S	Phage conserved hypothetical protein BR0599	-	-	-	-	-	-	-	-	-	-	-	-	DUF2163,Phage_BR0599
TLS3_k127_5686834_0	272943.RSP_2476	6.059e-90	302.0	COG5448@1|root,COG5448@2|Bacteria,1MXM8@1224|Proteobacteria,2TTJ3@28211|Alphaproteobacteria,1FCKN@1060|Rhodobacter	28211|Alphaproteobacteria	S	Conserved hypothetical protein 2217 (DUF2460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2460
TLS3_k127_5686834_2	1121271.AUCM01000001_gene3366	3.21e-64	226.0	COG5281@1|root,COG5281@2|Bacteria,1R47M@1224|Proteobacteria,2TUIV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG5281, Phage-related minor tail protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5686834_7	1123247.AUIJ01000006_gene3304	8.467e-11	70.0	2E2Z2@1|root,32XZR@2|Bacteria,1NA9J@1224|Proteobacteria,2UFQ5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phage tail assembly chaperone protein, TAC	-	-	-	-	-	-	-	-	-	-	-	-	Phage_TAC_6
TLS3_k127_5686834_4	1288298.rosmuc_03453	1.411e-29	127.0	2CN1W@1|root,32SG3@2|Bacteria,1N0IV@1224|Proteobacteria,2UC9F@28211|Alphaproteobacteria,46R2N@74030|Roseovarius	28211|Alphaproteobacteria	S	Phage tail tube protein, GTA-gp10	-	-	-	-	-	-	-	-	-	-	-	-	Phage_TAC_11
TLS3_k127_5686834_3	1123501.KB902276_gene1253	9.828e-64	221.0	COG5437@1|root,COG5437@2|Bacteria,1RH1Z@1224|Proteobacteria,2U9I4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Major tail protein, TP901-1 family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_tail_2
TLS3_k127_5686834_6	398580.Dshi_2171	4.775e-24	111.0	2DE8C@1|root,32U2V@2|Bacteria,1MZH7@1224|Proteobacteria,2UBWF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	gene transfer agent protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3168
TLS3_k127_5686834_5	246200.SPO2259	2.129e-28	119.0	COG5614@1|root,COG5614@2|Bacteria,1N0CB@1224|Proteobacteria,2UBY8@28211|Alphaproteobacteria,4NCE4@97050|Ruegeria	28211|Alphaproteobacteria	S	Head-tail adaptor	-	-	-	-	-	-	-	-	-	-	-	-	Phage_H_T_join
TLS3_k127_5686834_8	1461693.ATO10_02035	2.313e-09	58.0	2CK39@1|root,32SBG@2|Bacteria,1MZ6F@1224|Proteobacteria,2UBT5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phage_connect_1
TLS3_k127_5692875_4	398580.Dshi_1578	1.046e-26	121.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2UGK6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
TLS3_k127_5692875_3	1443111.JASG01000004_gene1327	4.377e-66	231.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,3ZX9H@60136|Sulfitobacter	28211|Alphaproteobacteria	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
TLS3_k127_5692875_2	1530186.JQEY01000002_gene1441	5.808e-96	329.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
TLS3_k127_5692875_1	1122218.KB893654_gene2566	6.415e-110	381.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria,1JSGV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
TLS3_k127_5692875_0	1122218.KB893654_gene2567	2.944e-120	395.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,1JR9F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	TIGRFAM nitrogen regulation protein NR(I)	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
TLS3_k127_5728840_3	1449049.JONW01000005_gene1260	2.234e-07	52.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TV3B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
TLS3_k127_5728840_1	1500301.JQMF01000023_gene5573	3.824e-114	374.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,2U0FJ@28211|Alphaproteobacteria,4BCAQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
TLS3_k127_5728840_0	395965.Msil_1169	5.826e-153	491.0	COG1503@1|root,COG1503@2|Bacteria,1MXX2@1224|Proteobacteria,2U2KZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5728840_2	1337093.MBE-LCI_1159	1.383e-23	102.0	COG2343@1|root,COG2343@2|Bacteria,1RHXD@1224|Proteobacteria,2UC5N@28211|Alphaproteobacteria,2P8ZT@245186|Loktanella	28211|Alphaproteobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS3_k127_5729671_4	1417296.U879_02300	2.544e-42	157.0	COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GcrA cell cycle regulator	gcrA	-	-	ko:K13583	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	GcrA
TLS3_k127_5729671_3	1121271.AUCM01000003_gene1740	4.955e-64	241.0	COG0596@1|root,COG2771@1|root,COG0596@2|Bacteria,COG2771@2|Bacteria,1RGAP@1224|Proteobacteria,2TXE8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator, LuxR family hydrolase, alpha beta fold family protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,GerE
TLS3_k127_5729671_0	1282876.BAOK01000001_gene3286	1.461e-99	343.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,4BQ0Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657,ko:K07659	ko02020,ko02026,map02020,map02026	M00434,M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_5729671_2	1161401.ASJA01000006_gene1881	1.577e-68	241.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,43XGE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS3_k127_5729671_1	426117.M446_1659	9.253e-90	309.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,1JT2R@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
TLS3_k127_5740558_1	349102.Rsph17025_1059	1.862e-41	162.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,1FCHZ@1060|Rhodobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF541)	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
TLS3_k127_5740558_0	1297570.MESS4_750112	3.937e-84	284.0	COG0500@1|root,COG2226@2|Bacteria,1R79J@1224|Proteobacteria,2U421@28211|Alphaproteobacteria,43GS7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_5745103_3	1449350.OCH239_21780	2.103e-84	284.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,4KKPJ@93682|Roseivivax	28211|Alphaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
TLS3_k127_5745103_0	266809.PM03_05555	2.686e-166	543.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	dctB	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1,dCache_3
TLS3_k127_5745103_1	1461693.ATO10_03105	1.66e-163	532.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	dctD	-	-	ko:K10126	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_5745103_2	1207063.P24_09921	1.728e-101	339.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2TRAK@28211|Alphaproteobacteria,2JZS5@204441|Rhodospirillales	204441|Rhodospirillales	K	COG0583 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_5748859_4	216596.pRL120201	3.556e-164	529.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TUYW@28211|Alphaproteobacteria,4B776@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K17203	ko02010,map02010	M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.11,3.A.1.2.16	-	-	BPD_transp_2
TLS3_k127_5748859_0	1449351.RISW2_00205	0.0	1041.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC transporter	-	-	-	ko:K17204	ko02010,map02010	M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.11,3.A.1.2.16	-	-	ABC_tran
TLS3_k127_5748859_7	1101189.AQUO01000002_gene668	1.243e-68	246.0	COG5618@1|root,COG5618@2|Bacteria,1RC24@1224|Proteobacteria,2U7AA@28211|Alphaproteobacteria,2PX5F@265|Paracoccus	28211|Alphaproteobacteria	S	Predicted periplasmic lipoprotein (DUF2291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2291
TLS3_k127_5748859_2	1101189.AQUO01000002_gene667	3.361e-223	706.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TVIT@28211|Alphaproteobacteria,2PWKD@265|Paracoccus	28211|Alphaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	eryA	-	2.7.1.215	ko:K00862	-	-	R11536	RC00017	ko00000,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_5748859_1	1410620.SHLA_5c000600	1.589e-253	803.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,4B6XW@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	eryB	-	1.1.1.402,1.1.5.3	ko:K00111,ko:K21054	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS3_k127_5748859_3	376733.IT41_12400	2.312e-173	547.0	COG1082@1|root,COG1082@2|Bacteria,1NWHA@1224|Proteobacteria,2U0VA@28211|Alphaproteobacteria,2PV4J@265|Paracoccus	28211|Alphaproteobacteria	G	Xylose isomerase domain protein TIM barrel	eryC	-	5.1.3.38	ko:K21909	-	-	-	-	ko00000,ko01000	-	-	-	AP_endonuc_2
TLS3_k127_5748859_5	1101189.AQUO01000002_gene664	9.874e-129	419.0	COG2390@1|root,COG2390@2|Bacteria,1MWHQ@1224|Proteobacteria,2TSIT@28211|Alphaproteobacteria,2PVMS@265|Paracoccus	28211|Alphaproteobacteria	K	Putative sugar-binding domain	eryD	-	-	-	-	-	-	-	-	-	-	-	Sugar-bind
TLS3_k127_5748859_6	1472418.BBJC01000001_gene834	2.553e-83	287.0	COG1178@1|root,COG3840@1|root,COG1178@2|Bacteria,COG3840@2|Bacteria,1MWCF@1224|Proteobacteria,2TQKC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG1178 ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
TLS3_k127_5752923_1	631454.N177_3134	2.125e-81	283.0	COG1216@1|root,COG1216@2|Bacteria,1R59U@1224|Proteobacteria,2TV7K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Involved in cell wall biogenesis	MA20_06075	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS3_k127_5752923_0	1122962.AULH01000026_gene3392	9.043e-144	485.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,36YVJ@31993|Methylocystaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	1.1.5.9	ko:K19813	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R00305	RC00066	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
TLS3_k127_5752923_2	1048834.TC41_0605	7.86e-45	178.0	COG4424@1|root,COG4424@2|Bacteria,1V5ZE@1239|Firmicutes,4HY3Z@91061|Bacilli	91061|Bacilli	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS3_k127_5752923_3	1096546.WYO_0562	1.169e-41	159.0	COG4636@1|root,COG4636@2|Bacteria,1RHNE@1224|Proteobacteria,2U9GQ@28211|Alphaproteobacteria,1JSJS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_5805675_4	661478.OP10G_0131	9.884e-06	51.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS3_k127_5805675_3	391626.OAN307_c03370	7.265e-18	86.0	COG0690@1|root,COG0690@2|Bacteria,1N75P@1224|Proteobacteria,2UF51@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS3_k127_5805675_0	1246459.KB898353_gene204	3.152e-88	311.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,4B7XG@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
TLS3_k127_5805675_1	42565.FP66_14095	1.62e-53	201.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1RZCF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS3_k127_5805675_2	762376.AXYL_03923	1.635e-29	121.0	COG2145@1|root,COG2145@2|Bacteria,1MVES@1224|Proteobacteria,2VRH7@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
TLS3_k127_5817750_2	1382303.JPOM01000001_gene1862	4.869e-74	258.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria,2KG1M@204458|Caulobacterales	204458|Caulobacterales	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
TLS3_k127_5817750_4	314256.OG2516_17690	3.365e-20	102.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2PDPV@252301|Oceanicola	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS3_k127_5817750_3	935261.JAGL01000030_gene288	2.786e-65	233.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,43RAG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_5817750_5	1287276.X752_29200	1.354e-16	83.0	2EJPG@1|root,33DEA@2|Bacteria,1NFP3@1224|Proteobacteria,2UK0D@28211|Alphaproteobacteria,43M53@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5817750_1	1449351.RISW2_05120	3.583e-92	311.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,4KKAJ@93682|Roseivivax	28211|Alphaproteobacteria	U	ABC 3 transport family	znuB	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS3_k127_5817750_0	1121271.AUCM01000010_gene2383	1.167e-94	317.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,2TQUI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TLS3_k127_5821733_4	1192868.CAIU01000017_gene2414	1.27e-124	419.0	COG1069@1|root,COG1069@2|Bacteria,1MY11@1224|Proteobacteria,2TTQN@28211|Alphaproteobacteria,43GVT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	TIGRFAM FGGY-family pentulose kinase	fggy	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
TLS3_k127_5821733_5	1410620.SHLA_12c000930	3.209e-56	223.0	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2U0W3@28211|Alphaproteobacteria,4B8EV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS3_k127_5821733_6	391625.PPSIR1_35707	3.03e-26	126.0	COG0454@1|root,COG0456@2|Bacteria,1N90X@1224|Proteobacteria	1224|Proteobacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS3_k127_5821733_0	1446473.JHWH01000007_gene576	7.957e-216	689.0	COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2TRBE@28211|Alphaproteobacteria,2PVR3@265|Paracoccus	28211|Alphaproteobacteria	G	Mannitol dehydrogenase Rossmann domain	mtlK	-	1.1.1.57,1.1.1.67	ko:K00040,ko:K00045	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00061	R00868,R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
TLS3_k127_5821733_1	1547437.LL06_13170	1.117e-177	560.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43IRG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ABC transporter	MA20_14720	-	-	ko:K10111	ko02010,map02010	M00194,M00200,M00204,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS3_k127_5821733_3	1547437.LL06_13175	9.096e-151	479.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TQJF@28211|Alphaproteobacteria,43IKC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	smoG	-	-	ko:K10229	ko02010,map02010	M00200	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.5	-	-	BPD_transp_1
TLS3_k127_5821733_2	1532558.JL39_22350	1.074e-156	499.0	COG1175@1|root,COG1175@2|Bacteria,1MVF1@1224|Proteobacteria,2TST1@28211|Alphaproteobacteria,4B8PS@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type sugar transport systems, permease components	smoF	-	-	ko:K10228	ko02010,map02010	M00200	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.5	-	-	BPD_transp_1
TLS3_k127_5823681_0	1125973.JNLC01000001_gene138	2.778e-113	371.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2TSNH@28211|Alphaproteobacteria,3JT2N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	MA20_04105	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_5823681_2	1041146.ATZB01000010_gene4006	7.185e-31	127.0	COG4319@1|root,COG4319@2|Bacteria,1NZK9@1224|Proteobacteria,2UEHY@28211|Alphaproteobacteria,4BEA8@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
TLS3_k127_5823681_1	1121861.KB899922_gene3157	8.417e-49	183.0	COG2764@1|root,COG2764@2|Bacteria,1RJPS@1224|Proteobacteria,2UACG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_5836283_3	290400.Jann_0275	5.611e-27	111.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase	gst	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N_3
TLS3_k127_5836283_2	1238182.C882_0589	2.158e-95	317.0	COG5530@1|root,COG5530@2|Bacteria,1R6P3@1224|Proteobacteria,2TUPW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2270
TLS3_k127_5836283_0	644107.SL1157_1037	6.617e-126	412.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,4NAIV@97050|Ruegeria	28211|Alphaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase isomerase	MA20_24380	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
TLS3_k127_5836283_1	290400.Jann_0247	3.209e-103	342.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	GO:0008150,GO:0042221,GO:0046677,GO:0050896	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS3_k127_5837836_5	1123229.AUBC01000008_gene499	3.234e-18	97.0	COG0644@1|root,COG0644@2|Bacteria,1RAS8@1224|Proteobacteria,2U5PA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_3,NAD_binding_8,Pyr_redox_2
TLS3_k127_5837836_1	314271.RB2654_20203	3.173e-72	276.0	COG0500@1|root,COG2226@2|Bacteria,1QYSR@1224|Proteobacteria,2TXZD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
TLS3_k127_5837836_0	1121106.JQKB01000035_gene6055	1.445e-109	372.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,2JVG5@204441|Rhodospirillales	204441|Rhodospirillales	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
TLS3_k127_5837836_3	640511.BC1002_4823	7.529e-66	235.0	COG3336@1|root,COG3336@2|Bacteria,1RDWT@1224|Proteobacteria,2VRQE@28216|Betaproteobacteria,1K234@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cytochrome c oxidase caa3-type, assembly factor	-	-	-	ko:K02351	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
TLS3_k127_5837836_4	640511.BC1002_4824	8.397e-31	141.0	COG1981@1|root,COG1981@2|Bacteria,1N2W1@1224|Proteobacteria,2W6GN@28216|Betaproteobacteria,1KD7E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0093)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0093
TLS3_k127_5837836_2	1121127.JAFA01000002_gene1568	2.167e-69	237.0	COG4244@1|root,COG4244@2|Bacteria,1RF4K@1224|Proteobacteria,2WE3P@28216|Betaproteobacteria,1KBK3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
TLS3_k127_5854576_2	1123237.Salmuc_02994	8.298e-99	330.0	COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,2TU5M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	NYN domain	MA20_36560	-	-	-	-	-	-	-	-	-	-	-	NYN
TLS3_k127_5854576_4	351016.RAZWK3B_09166	8.748e-52	189.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,2P3A2@2433|Roseobacter	28211|Alphaproteobacteria	H	COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
TLS3_k127_5854576_5	314265.R2601_11619	3.651e-50	181.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS3_k127_5854576_0	1417296.U879_16015	0.0	1009.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS3_k127_5854576_3	1417296.U879_16020	1.434e-53	197.0	COG3216@1|root,COG3216@2|Bacteria,1QA1I@1224|Proteobacteria,2TS9W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
TLS3_k127_5854576_1	1123501.KB902300_gene3925	3.717e-102	336.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
TLS3_k127_5887248_2	402881.Plav_3622	1.659e-25	110.0	COG1396@1|root,COG1396@2|Bacteria,1RDBW@1224|Proteobacteria,2U7CY@28211|Alphaproteobacteria,1JPB6@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	QU41_21520	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS3_k127_5887248_0	1417296.U879_10660	1.845e-202	636.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS3_k127_5887248_1	195105.CN97_01845	8.348e-78	269.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
TLS3_k127_5904677_1	266835.14023678	1.065e-156	504.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43IBF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS3_k127_5904677_6	1380394.JADL01000003_gene4934	1.36e-30	125.0	2C1J2@1|root,32R8T@2|Bacteria,1MYNF@1224|Proteobacteria,2U9IR@28211|Alphaproteobacteria,2JWGW@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5904677_3	1380391.JIAS01000011_gene4631	6.929e-137	443.0	COG0524@1|root,COG0524@2|Bacteria,1NA08@1224|Proteobacteria,2U1CN@28211|Alphaproteobacteria,2JW5U@204441|Rhodospirillales	204441|Rhodospirillales	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
TLS3_k127_5904677_5	1410620.SHLA_39c000750	9.251e-41	166.0	COG3254@1|root,COG3254@2|Bacteria,1RGZM@1224|Proteobacteria,2VGR7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	L-rhamnose mutarotase	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
TLS3_k127_5904677_4	290400.Jann_3057	7.189e-72	260.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2TV15@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17203	ko02010,map02010	M00212,M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19	-	-	BPD_transp_2
TLS3_k127_5904677_0	1123229.AUBC01000012_gene2681	1.268e-224	711.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,3JQYV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TLS3_k127_5904677_2	1123229.AUBC01000012_gene2682	1.736e-146	471.0	COG1172@1|root,COG1172@2|Bacteria,1RBVF@1224|Proteobacteria,2U58Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS3_k127_592394_1	1294273.roselon_01648	3.453e-209	659.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS3_k127_592394_3	1530186.JQEY01000001_gene934	4.941e-41	159.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2UC7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_592394_2	318586.Pden_3784	5.308e-65	235.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,2PUV7@265|Paracoccus	28211|Alphaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
TLS3_k127_592394_0	1188256.BASI01000005_gene1963	3.046e-302	932.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,3FCS0@34008|Rhodovulum	28211|Alphaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS3_k127_592394_4	1123355.JHYO01000026_gene221	6.325e-05	49.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,36X8K@31993|Methylocystaceae	28211|Alphaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS3_k127_5948051_1	1038858.AXBA01000038_gene5053	2.994e-82	280.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3EY3U@335928|Xanthobacteraceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K21134	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27	-	-	ACR_tran
TLS3_k127_5948051_3	1417296.U879_00075	2.323e-70	253.0	COG0477@1|root,COG2814@2|Bacteria,1MX4G@1224|Proteobacteria,2TTT7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_5948051_2	1101189.AQUO01000001_gene2218	2.226e-75	267.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria,2PVF4@265|Paracoccus	28211|Alphaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
TLS3_k127_5948051_0	266779.Meso_2091	7.951e-126	406.0	COG1960@1|root,COG1960@2|Bacteria,1MW97@1224|Proteobacteria,2TUS1@28211|Alphaproteobacteria,43J9C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_38160	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_5955077_1	1226994.AMZB01000109_gene1763	7.333e-109	356.0	COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,1RZSD@1236|Gammaproteobacteria,1YE2B@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Creatinase/Prolidase N-terminal domain	doeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019752,GO:0032787,GO:0042399,GO:0042400,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046700,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.4.13.9,3.5.4.44	ko:K01271,ko:K15783	ko00260,ko01100,map00260,map01100	-	R09800	RC02661	ko00000,ko00001,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
TLS3_k127_5955077_0	1123237.Salmuc_01907	8.932e-138	454.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE_1	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_5963412_7	1121106.JQKB01000015_gene5814	1.998e-59	210.0	COG2227@1|root,COG2227@2|Bacteria,1N2VZ@1224|Proteobacteria,2TU4Z@28211|Alphaproteobacteria,2JR97@204441|Rhodospirillales	204441|Rhodospirillales	H	Magnesium-protoporphyrin IX methyltransferase C-terminus	bchM	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	MTS,Mg-por_mtran_C,PrmA
TLS3_k127_5963412_1	351016.RAZWK3B_19556	4.77e-184	595.0	COG0477@1|root,COG2814@2|Bacteria,1MW95@1224|Proteobacteria,2TS8H@28211|Alphaproteobacteria,2P1JS@2433|Roseobacter	28211|Alphaproteobacteria	EGP	PUCC protein	lhaA	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
TLS3_k127_5963412_4	1366046.HIMB11_02818	1.574e-89	302.0	COG3861@1|root,COG3861@2|Bacteria,1NU42@1224|Proteobacteria,2TTV5@28211|Alphaproteobacteria,3ZI7M@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	S	Photosynthetic reaction centre, H-chain N-terminal region	puhA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464	-	ko:K13991	ko02020,map02020	-	-	-	ko00000,ko00001,ko00194	-	-	-	PRC,PRCH
TLS3_k127_5963412_8	1123237.Salmuc_00119	1.679e-54	198.0	COG3428@1|root,COG3428@2|Bacteria,1RHA4@1224|Proteobacteria,2UA6D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial PH domain	puhB	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS3_k127_5963412_9	272943.RSP_6110	3.25e-42	172.0	2E7QH@1|root,3325Y@2|Bacteria,1MZ3C@1224|Proteobacteria,2UG5F@28211|Alphaproteobacteria,1FCUM@1060|Rhodobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5963412_3	371731.Rsw2DRAFT_0898	5.137e-181	578.0	COG1633@1|root,COG1633@2|Bacteria,1N5FH@1224|Proteobacteria,2TU0E@28211|Alphaproteobacteria,1FCD9@1060|Rhodobacter	28211|Alphaproteobacteria	H	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	acsF	-	1.14.13.81	ko:K04035	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06265,R06266,R06267,R10068	RC00741,RC01491,RC01492,RC03042	ko00000,ko00001,ko01000	-	-	-	Rubrerythrin
TLS3_k127_5963412_5	1294273.roselon_01109	2.106e-89	304.0	COG0523@1|root,COG0523@2|Bacteria,1MY4T@1224|Proteobacteria,2U0DU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Photosynthetic complex assembly protein 2	puhE	-	-	-	-	-	-	-	-	-	-	-	DUF3623
TLS3_k127_5963412_0	1120983.KB894571_gene2465	1.228e-202	651.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,1JN7T@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	Cys/Met metabolism PLP-dependent enzyme	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_5963412_11	314265.R2601_26571	5.606e-26	109.0	COG2906@1|root,COG2906@2|Bacteria,1N0J0@1224|Proteobacteria,2UD47@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	bacterioferritin-associated ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
TLS3_k127_5963412_6	1317118.ATO8_10088	6.142e-76	258.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2U70I@28211|Alphaproteobacteria,4KM6R@93682|Roseivivax	28211|Alphaproteobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS3_k127_5963412_2	622637.KE124774_gene895	3.864e-182	584.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,36XXG@31993|Methylocystaceae	28211|Alphaproteobacteria	P	STAS domain	MA20_05210	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS3_k127_5970435_1	1449351.RISW2_08015	5.101e-59	209.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,4KMBI@93682|Roseivivax	28211|Alphaproteobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS3_k127_5970435_2	1123247.AUIJ01000002_gene2305	1.558e-29	122.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,2UCF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	DnaK suppressor protein	dskA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
TLS3_k127_5970435_0	314270.RB2083_1037	4.721e-159	503.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,3ZG2S@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	H	Cobalamin biosynthesis protein CobT	cobT	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
TLS3_k127_6010466_4	1121939.L861_09330	3.167e-05	49.0	COG3133@1|root,COG3133@2|Bacteria,1RA1D@1224|Proteobacteria,1S202@1236|Gammaproteobacteria,1XKSA@135619|Oceanospirillales	135619|Oceanospirillales	M	Glycine zipper 2TM domain	-	-	-	ko:K06077	-	-	-	-	ko00000	-	-	-	Rick_17kDa_Anti
TLS3_k127_6010466_0	1380391.JIAS01000015_gene109	2.97e-115	386.0	COG0111@1|root,COG0111@2|Bacteria,1R76G@1224|Proteobacteria,2VGNT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_6010466_2	1530186.JQEY01000011_gene2649	2.757e-77	273.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	uracil-DNA glycosylase	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS3_k127_6010466_1	266809.PM03_08405	4.644e-85	287.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
TLS3_k127_6010466_3	1449351.RISW2_13270	1.162e-49	187.0	COG4233@1|root,COG4233@2|Bacteria,1REVE@1224|Proteobacteria,2VEXK@28211|Alphaproteobacteria,4KKJD@93682|Roseivivax	28211|Alphaproteobacteria	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
TLS3_k127_6025003_1	765912.Thimo_3173	1.022e-139	457.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,1RMBV@1236|Gammaproteobacteria,1WW88@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM Penicillin-binding protein 1C	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
TLS3_k127_6025003_0	1121271.AUCM01000005_gene687	1.401e-178	567.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
TLS3_k127_6027713_0	1510531.JQJJ01000008_gene3890	2.071e-158	507.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,3JQQS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
TLS3_k127_6027713_1	1287276.X752_12195	1.974e-124	411.0	COG1940@1|root,COG2345@1|root,COG1940@2|Bacteria,COG2345@2|Bacteria,1MVGQ@1224|Proteobacteria,2TRFX@28211|Alphaproteobacteria,43I6N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
TLS3_k127_6027713_2	411684.HPDFL43_00890	9.354e-09	59.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TT8F@28211|Alphaproteobacteria,43HQZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10552	ko02010,map02010	M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.7	-	-	Peripla_BP_4
TLS3_k127_6033164_2	1121106.JQKB01000007_gene1077	6.585e-104	362.0	COG3629@1|root,COG3629@2|Bacteria,1MV0P@1224|Proteobacteria,2U2U5@28211|Alphaproteobacteria,2JXTW@204441|Rhodospirillales	204441|Rhodospirillales	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
TLS3_k127_6033164_4	1121106.JQKB01000007_gene1075	9.111e-47	192.0	2DB71@1|root,2Z7JE@2|Bacteria,1NAGB@1224|Proteobacteria,2TSB5@28211|Alphaproteobacteria,2JU99@204441|Rhodospirillales	204441|Rhodospirillales	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
TLS3_k127_6033164_5	1353531.AZNX01000006_gene5712	3.407e-46	181.0	COG1609@1|root,COG1609@2|Bacteria,1R40Q@1224|Proteobacteria,2TTX2@28211|Alphaproteobacteria,4B7UB@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS3_k127_6033164_0	1381123.AYOD01000035_gene3736	3.025e-186	591.0	COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,2TR6B@28211|Alphaproteobacteria,43HZH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_6033164_3	1089551.KE386572_gene298	1.11e-91	310.0	COG1082@1|root,COG1082@2|Bacteria,1QYE4@1224|Proteobacteria,2TXTQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS3_k127_6033164_1	1510531.JQJJ01000013_gene131	2.162e-108	352.0	COG1082@1|root,COG1082@2|Bacteria,1MVSJ@1224|Proteobacteria,2TV5J@28211|Alphaproteobacteria,3JQNF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS3_k127_6045584_0	1411123.JQNH01000001_gene3067	4.871e-160	533.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS3_k127_6045584_3	864069.MicloDRAFT_00065340	2.586e-66	244.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria,1JT3J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS3_k127_6045584_4	272943.RSP_1594	5.824e-40	170.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,1FBUZ@1060|Rhodobacter	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
TLS3_k127_6045584_1	1188256.BASI01000005_gene1827	5.332e-156	531.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3FCZN@34008|Rhodovulum	28211|Alphaproteobacteria	T	Sigma-54 interaction domain	luxO	-	-	ko:K10912	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00513	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
TLS3_k127_6045584_2	398580.Dshi_0824	6.964e-80	287.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1R5C7@1224|Proteobacteria,2TS7V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
TLS3_k127_6045584_6	1122201.AUAZ01000018_gene1660	1.114e-22	113.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,46DD6@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07678,ko:K20974	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
TLS3_k127_6045584_5	314256.OG2516_07273	3.31e-32	132.0	COG3915@1|root,COG3915@2|Bacteria,1RHJS@1224|Proteobacteria,2U8BH@28211|Alphaproteobacteria,2PEJ1@252301|Oceanicola	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS3_k127_6046234_2	314271.RB2654_20893	2.942e-88	308.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
TLS3_k127_6046234_0	272943.RSP_0675	2.221e-119	389.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,1FBA9@1060|Rhodobacter	28211|Alphaproteobacteria	L	TIGRFAM hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
TLS3_k127_6046234_1	1469613.JT55_17485	2.049e-102	350.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,3FD07@34008|Rhodovulum	28211|Alphaproteobacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
TLS3_k127_6046234_3	266809.PM03_12460	8.827e-76	259.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
TLS3_k127_6046234_4	391593.RCCS2_02815	3.276e-15	79.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,2P1E7@2433|Roseobacter	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
TLS3_k127_6048206_2	1040983.AXAE01000004_gene737	1.901e-122	417.0	COG2723@1|root,COG2723@2|Bacteria,1R87Y@1224|Proteobacteria,2U2WT@28211|Alphaproteobacteria,43N9E@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,Glyco_hydro_53,Glyco_hydro_cc
TLS3_k127_6048206_1	1082931.KKY_934	7.527e-185	599.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,3N6QE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS3_k127_6048206_0	1037409.BJ6T_32800	1.318e-216	680.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,3JQX1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptidase dimerisation domain	dapE_1	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_6048206_3	420324.KI912037_gene2409	1.696e-47	172.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,1JS1S@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS3_k127_606960_4	1294273.roselon_01119	2.749e-17	90.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
TLS3_k127_606960_3	388401.RB2150_12381	7.269e-59	216.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,3ZH8D@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	J	nucleic-acid-binding protein implicated in transcription termination	MA20_23920	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448,Ribosomal_L7Ae
TLS3_k127_606960_0	1353537.TP2_06180	8.659e-248	789.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,2XMYM@285107|Thioclava	28211|Alphaproteobacteria	J	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
TLS3_k127_606960_2	89187.ISM_06535	1.079e-68	253.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria,46PCY@74030|Roseovarius	28211|Alphaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS3_k127_606960_1	1461693.ATO10_06441	1.558e-87	292.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2TSK7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain	regA	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
TLS3_k127_6078377_4	571166.KI421509_gene4045	9.771e-11	70.0	2B214@1|root,31UHY@2|Bacteria,1RJXN@1224|Proteobacteria,2U9RS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6078377_3	999547.KI421500_gene3183	3.797e-93	311.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,280IF@191028|Leisingera	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_6078377_1	391613.RTM1035_07589	5.443e-102	353.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,46P8D@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_6078377_0	999547.KI421500_gene3181	1.776e-137	455.0	COG4177@1|root,COG4177@2|Bacteria,1MXPG@1224|Proteobacteria,2VFF4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
TLS3_k127_6078377_2	439496.RBY4I_3239	6.548e-100	329.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_6089680_4	1122218.KB893653_gene396	3.665e-62	220.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2U9H5@28211|Alphaproteobacteria,1JSEK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	D	PFAM Maf family protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS3_k127_6089680_1	1367847.JCM7686_3459	2.984e-103	357.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,2PUKI@265|Paracoccus	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
TLS3_k127_6089680_5	1417296.U879_11385	9.485e-60	222.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
TLS3_k127_6089680_3	1123501.KB902314_gene3195	4.052e-95	316.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
TLS3_k127_6089680_6	398580.Dshi_3447	1.79e-52	203.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
TLS3_k127_6089680_2	398580.Dshi_3276	1.846e-99	345.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2TUHX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
TLS3_k127_6089680_0	1342302.JASC01000013_gene2876	3.806e-164	519.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,3ZVR0@60136|Sulfitobacter	28211|Alphaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00410,ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
TLS3_k127_6115430_1	644107.SL1157_1387	1.583e-104	345.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,4NAXQ@97050|Ruegeria	28211|Alphaproteobacteria	O	DnaJ C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
TLS3_k127_6115430_2	331869.BAL199_27196	2.453e-16	83.0	COG0789@1|root,COG0789@2|Bacteria,1N831@1224|Proteobacteria,2UFMB@28211|Alphaproteobacteria,4BSX4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
TLS3_k127_6115430_0	1123229.AUBC01000006_gene880	2.736e-294	921.0	COG4222@1|root,COG4222@2|Bacteria,1MVDD@1224|Proteobacteria,2TRWJ@28211|Alphaproteobacteria,3K3KG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Esterase-like activity of phytase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Phytase-like
TLS3_k127_6131293_4	1367847.JCM7686_2328	8.69e-37	152.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.30	ko:K18608	ko00750,ko01120,map00750,map01120	-	R01712	RC00008,RC00048	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS3_k127_6131293_2	1188256.BASI01000003_gene2887	1.054e-112	377.0	COG4608@1|root,COG4608@2|Bacteria,1R6HX@1224|Proteobacteria,2U41F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran
TLS3_k127_6131293_3	1188256.BASI01000003_gene2886	2e-96	337.0	COG0444@1|root,COG0444@2|Bacteria,1RA5C@1224|Proteobacteria,2U6CF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC transporter	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran
TLS3_k127_6131293_1	1188256.BASI01000003_gene2885	6.691e-120	404.0	COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,2TQVQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS3_k127_6131293_0	1188256.BASI01000003_gene2884	4.369e-142	454.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQJC@28211|Alphaproteobacteria,3FDZ4@34008|Rhodovulum	28211|Alphaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_613220_0	398580.Dshi_2695	9.874e-147	469.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2TS3I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	urtA	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
TLS3_k127_613220_1	398580.Dshi_2692	1.138e-72	256.0	COG2304@1|root,COG2304@2|Bacteria,1PH4N@1224|Proteobacteria,2TQTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF1194
TLS3_k127_6160056_4	1367847.JCM7686_3062	2.733e-18	85.0	COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria,2PWDY@265|Paracoccus	28211|Alphaproteobacteria	S	GcrA cell cycle regulator	gcrA	-	-	ko:K13583	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	GcrA
TLS3_k127_6160056_1	1188256.BASI01000002_gene3325	5.599e-110	366.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria,3FEC7@34008|Rhodovulum	28211|Alphaproteobacteria	U	ABC-2 type transporter	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS3_k127_6160056_3	1380394.JADL01000006_gene5319	1.099e-43	168.0	COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,2TSJZ@28211|Alphaproteobacteria,2JRRK@204441|Rhodospirillales	204441|Rhodospirillales	D	VirC1 protein	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
TLS3_k127_6160056_0	1502724.FF80_01845	4.233e-248	781.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,3N7WA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Alpha-amylase domain	aglA2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
TLS3_k127_6160056_2	1267535.KB906767_gene4364	9.067e-69	239.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
TLS3_k127_6178415_1	1353537.TP2_09650	3.612e-178	594.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,2XMT3@285107|Thioclava	28211|Alphaproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
TLS3_k127_6178415_2	1440774.Y900_016025	2.536e-163	525.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,235P0@1762|Mycobacteriaceae	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	algD	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS3_k127_6178415_4	211165.AJLN01000100_gene4202	9.602e-55	216.0	COG0438@1|root,COG0438@2|Bacteria,1GF3Y@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6178415_3	318996.AXAZ01000097_gene2487	1.906e-109	379.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2TRZB@28211|Alphaproteobacteria,3K08D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
TLS3_k127_6178415_0	1354722.JQLS01000004_gene4061	9.733e-195	621.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2TUKE@28211|Alphaproteobacteria,46RQV@74030|Roseovarius	28211|Alphaproteobacteria	C	Protein of unknown function (DUF3485)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
TLS3_k127_6178415_5	351016.RAZWK3B_01035	6.741e-20	103.0	COG5338@1|root,COG5338@2|Bacteria,1RJS0@1224|Proteobacteria,2UB2K@28211|Alphaproteobacteria,2P3N6@2433|Roseobacter	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6218772_0	744979.R2A130_1633	2.311e-140	451.0	COG0714@1|root,COG0714@2|Bacteria,1NWIN@1224|Proteobacteria,2TTPB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	AAA domain (dynein-related subfamily)	MA20_13975	-	-	-	-	-	-	-	-	-	-	-	AAA_5
TLS3_k127_6218772_2	388399.SSE37_21535	3.904e-111	384.0	COG3552@1|root,COG3552@2|Bacteria,1MUEJ@1224|Proteobacteria,2TQQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein containing von Willebrand factor type A (VWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_6218772_1	1126627.BAWE01000004_gene3543	2.88e-119	407.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRQX@28211|Alphaproteobacteria,3JRD4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
TLS3_k127_622754_2	1211115.ALIQ01000198_gene462	1.292e-90	309.0	COG0673@1|root,COG0673@2|Bacteria,1PENS@1224|Proteobacteria,2V8D0@28211|Alphaproteobacteria,3NCVD@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS3_k127_622754_0	1211115.ALIQ01000198_gene463	1.243e-172	567.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3NAJC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS3_k127_622754_1	1211115.ALIQ01000198_gene464	1.999e-136	441.0	COG3386@1|root,COG3386@2|Bacteria,1MVQM@1224|Proteobacteria,2U3TF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
TLS3_k127_6247564_0	1294273.roselon_01233	5.372e-84	280.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
TLS3_k127_6247564_2	633149.Bresu_2891	5.422e-20	98.0	2EE5H@1|root,33801@2|Bacteria,1NFKZ@1224|Proteobacteria,2UIVJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
TLS3_k127_6247564_1	1121939.L861_14940	1.423e-43	168.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS3_k127_6247564_3	1446473.JHWH01000011_gene864	1.033e-19	93.0	COG3568@1|root,COG3568@2|Bacteria,1QV2C@1224|Proteobacteria,2U065@28211|Alphaproteobacteria,2PWCT@265|Paracoccus	28211|Alphaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_6259756_1	631454.N177_1006	2.309e-31	124.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2U14G@28211|Alphaproteobacteria,1JPV8@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_6259756_3	269796.Rru_A3379	2.174e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,1RK4Q@1224|Proteobacteria,2UBBB@28211|Alphaproteobacteria,2JSKY@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_9
TLS3_k127_6259756_0	501479.ACNW01000047_gene441	6.775e-106	363.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2TRDY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_6259756_2	349102.Rsph17025_2626	9.653e-13	72.0	COG3637@1|root,COG3637@2|Bacteria,1QV2K@1224|Proteobacteria,2TR2T@28211|Alphaproteobacteria,1FCCI@1060|Rhodobacter	28211|Alphaproteobacteria	M	Exopolysaccharide biosynthesis protein YbjH	-	-	-	-	-	-	-	-	-	-	-	-	YjbH
TLS3_k127_6260870_2	351016.RAZWK3B_05232	2.023e-77	267.0	COG2186@1|root,COG2186@2|Bacteria,1MY1K@1224|Proteobacteria,2U67X@28211|Alphaproteobacteria,2P3U6@2433|Roseobacter	28211|Alphaproteobacteria	K	COG2186 Transcriptional regulators	-	-	-	ko:K19775	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
TLS3_k127_6260870_1	351016.RAZWK3B_02015	7.673e-113	377.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2TS7I@28211|Alphaproteobacteria,2P1MP@2433|Roseobacter	28211|Alphaproteobacteria	K	COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	glxA	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
TLS3_k127_6260870_3	351016.RAZWK3B_01995	9.895e-40	156.0	COG4583@1|root,COG4583@2|Bacteria,1RC66@1224|Proteobacteria,2U5RU@28211|Alphaproteobacteria,2P396@2433|Roseobacter	28211|Alphaproteobacteria	E	COG4583 Sarcosine oxidase gamma subunit	soxGe	-	1.5.3.1	ko:K00305	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
TLS3_k127_6260870_0	351016.RAZWK3B_02000	5.45e-275	857.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,2P11E@2433|Roseobacter	28211|Alphaproteobacteria	C	Sarcosine oxidase, alpha subunit family	soxA2	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
TLS3_k127_6266610_0	1449351.RISW2_16455	1.553e-100	363.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,2TVMQ@28211|Alphaproteobacteria,4KM9P@93682|Roseivivax	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_6266610_1	1123501.KB902276_gene1108	1.313e-88	296.0	COG0454@1|root,COG0454@2|Bacteria,1RDBA@1224|Proteobacteria,2TTF2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_6266610_2	1150469.RSPPHO_02169	1.08e-26	126.0	COG0477@1|root,COG0477@2|Bacteria,1QTUM@1224|Proteobacteria,2TVX9@28211|Alphaproteobacteria,2JZ14@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_6266610_3	1188256.BASI01000001_gene476	6.362e-12	68.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,3FCJX@34008|Rhodovulum	28211|Alphaproteobacteria	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
TLS3_k127_6270127_2	1294273.roselon_02392	2.473e-26	115.0	COG1196@1|root,COG1196@2|Bacteria,1NEMB@1224|Proteobacteria,2UIE7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6270127_0	765698.Mesci_1970	9.873e-138	451.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria,43HFW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
TLS3_k127_6270127_1	467661.RKLH11_2599	5.98e-75	254.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,3ZG8J@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS3_k127_6273950_3	743721.Psesu_1123	1.691e-08	63.0	2DTVY@1|root,33MW8@2|Bacteria,1P6ST@1224|Proteobacteria,1SU01@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6273950_4	492774.JQMB01000003_gene2733	4.378e-08	56.0	COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,2TS5Z@28211|Alphaproteobacteria,4B9MV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Major facilitator superfamily	fsr	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
TLS3_k127_6273950_1	1410620.SHLA_57c000220	4.873e-30	126.0	COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,2TS5Z@28211|Alphaproteobacteria,4B9MV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Major facilitator superfamily	fsr	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
TLS3_k127_6273950_2	1033732.CAHI01000015_gene464	3.912e-11	70.0	COG0477@1|root,COG2814@2|Bacteria,4NE1N@976|Bacteroidetes,2FW79@200643|Bacteroidia	976|Bacteroidetes	EGP	Transporter, major facilitator family protein	fsr	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
TLS3_k127_6273950_0	371731.Rsw2DRAFT_1440	6.616e-134	437.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,1FB20@1060|Rhodobacter	28211|Alphaproteobacteria	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
TLS3_k127_6289120_1	570967.JMLV01000002_gene1603	1.116e-139	448.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,2JTKV@204441|Rhodospirillales	204441|Rhodospirillales	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
TLS3_k127_6289120_2	83219.PM02_15310	7.963e-119	411.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2TS4Z@28211|Alphaproteobacteria,3ZVDQ@60136|Sulfitobacter	28211|Alphaproteobacteria	V	MatE	matE	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS3_k127_6289120_3	190650.CC_0994	1.547e-106	349.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2KEZ9@204458|Caulobacterales	204458|Caulobacterales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS3_k127_6289120_0	1415756.JQMY01000001_gene1856	3.368e-150	492.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2PCPM@252301|Oceanicola	28211|Alphaproteobacteria	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS3_k127_6349434_0	1123237.Salmuc_04054	5.736e-66	227.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2U7DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG2148 Sugar transferases involved in lipopolysaccharide synthesis	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
TLS3_k127_6349434_1	314264.ROS217_07550	1.617e-57	216.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2U0F2@28211|Alphaproteobacteria,46RG9@74030|Roseovarius	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS3_k127_638513_1	1123501.KB902288_gene1710	2.8e-10	65.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TRCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacF	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11,SPOR
TLS3_k127_638513_0	375451.RD1_0515	2e-94	316.0	COG1309@1|root,COG1309@2|Bacteria,1R5AI@1224|Proteobacteria,2U7HG@28211|Alphaproteobacteria,2P57J@2433|Roseobacter	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	MA20_16910	-	-	-	-	-	-	-	-	-	-	-	TetR_C_3,TetR_C_9,TetR_N
TLS3_k127_6397441_0	398580.Dshi_0059	1.996e-274	853.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS3_k127_6397441_3	1123060.JONP01000067_gene840	8.297e-37	148.0	COG2931@1|root,COG3866@1|root,COG2931@2|Bacteria,COG3866@2|Bacteria,1MU7T@1224|Proteobacteria,2UCFI@28211|Alphaproteobacteria,2JZKD@204441|Rhodospirillales	28211|Alphaproteobacteria	GQ	Amb_all	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,HemolysinCabind,Pec_lyase_C
TLS3_k127_6397441_2	1122218.KB893653_gene551	1.383e-73	258.0	COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,2TUIN@28211|Alphaproteobacteria,1JTT9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
TLS3_k127_6397441_1	1121271.AUCM01000005_gene700	1.722e-99	332.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,2TS6Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_6412385_0	1122132.AQYH01000002_gene1359	1.706e-175	590.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,4BBWI@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS3_k127_6412385_2	266779.Meso_2092	3.113e-109	357.0	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2U0MC@28211|Alphaproteobacteria,43J4M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS3_k127_6412385_1	1353531.AZNX01000008_gene645	3.375e-161	517.0	COG1960@1|root,COG1960@2|Bacteria,1MW97@1224|Proteobacteria,2TUS1@28211|Alphaproteobacteria,4B84H@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_38160	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_6413237_2	1120966.AUBU01000012_gene175	1.086e-55	209.0	COG0189@1|root,COG0189@2|Bacteria,4NF3Y@976|Bacteroidetes	976|Bacteroidetes	HJ	Sugar-transfer associated ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST
TLS3_k127_6413237_3	1279038.KB907343_gene2467	8.242e-28	116.0	COG3450@1|root,COG3450@2|Bacteria,1N0F7@1224|Proteobacteria,2UG5M@28211|Alphaproteobacteria,2JUD0@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
TLS3_k127_6413237_0	1267005.KB911264_gene3200	2.824e-81	275.0	COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria,2UDER@28211|Alphaproteobacteria,3N73T@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Cupin domain	manC	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_6413237_1	1054213.HMPREF9946_00141	5.508e-72	259.0	COG3247@1|root,COG3247@2|Bacteria,1N5EQ@1224|Proteobacteria,2TRDZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	response to pH	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6419083_0	1122614.JHZF01000011_gene991	1.171e-198	630.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2PD31@252301|Oceanicola	28211|Alphaproteobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
TLS3_k127_6419083_1	371731.Rsw2DRAFT_1308	7.427e-59	210.0	29M59@1|root,3082Q@2|Bacteria,1PUXY@1224|Proteobacteria,2U6M4@28211|Alphaproteobacteria,1FBRJ@1060|Rhodobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
TLS3_k127_6442431_0	1569209.BBPH01000089_gene2084	2.019e-133	434.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,2PYCR@265|Paracoccus	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_6442431_1	398580.Dshi_1004	1.613e-62	222.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_6442733_2	596151.DesfrDRAFT_2590	6.625e-43	175.0	COG0279@1|root,COG2605@1|root,COG0279@2|Bacteria,COG2605@2|Bacteria,1QWU7@1224|Proteobacteria,42QI3@68525|delta/epsilon subdivisions,2X8DE@28221|Deltaproteobacteria,2MGSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,SIS_2
TLS3_k127_6442733_1	1128421.JAGA01000003_gene3697	7.634e-88	299.0	COG1028@1|root,COG1028@2|Bacteria	1128421.JAGA01000003_gene3697|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6442733_0	479434.Sthe_0047	3.792e-104	346.0	COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi,27Z3S@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_6443372_6	1410620.SHLA_9c000180	4.898e-12	78.0	COG1079@1|root,COG1079@2|Bacteria,1NAYV@1224|Proteobacteria,2TTM0@28211|Alphaproteobacteria,4B77I@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_6443372_3	1410620.SHLA_9c000170	8.314e-142	483.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2TUGD@28211|Alphaproteobacteria,4B70W@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_6443372_0	1123237.Salmuc_00046	2.034e-182	615.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC transporter	rbsA4	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_6443372_1	1547437.LL06_13255	3.386e-156	502.0	COG1744@1|root,COG1744@2|Bacteria,1MVU5@1224|Proteobacteria,2TTTH@28211|Alphaproteobacteria,43HCV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
TLS3_k127_6443372_7	467661.RKLH11_619	2.051e-09	71.0	29724@1|root,2ZUAH@2|Bacteria,1RGP1@1224|Proteobacteria,2U8AW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6443372_2	1547437.LL06_06650	3.504e-151	505.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2TQU5@28211|Alphaproteobacteria,43HAN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	MA20_22065	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B
TLS3_k127_6443372_5	1123237.Salmuc_02872	3.439e-88	309.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS3_k127_6443372_4	1437448.AZRT01000012_gene707	2.205e-93	341.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,1J3CU@118882|Brucellaceae	28211|Alphaproteobacteria	L	ATP dependent DNA ligase C terminal region	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS3_k127_644815_6	1449351.RISW2_12475	2.15e-64	224.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,4KKZ8@93682|Roseivivax	28211|Alphaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS3_k127_644815_7	398580.Dshi_0179	1.619e-59	229.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.31,3.5.1.88	ko:K01450,ko:K01462	ko00270,ko00630,map00270,map00630	-	R00653	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	Pep_deformylase
TLS3_k127_644815_2	1317124.DW2_11666	1.733e-140	469.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,2TR29@28211|Alphaproteobacteria,2XMX6@285107|Thioclava	28211|Alphaproteobacteria	E	Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_644815_1	1417296.U879_19800	2.393e-155	496.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	mcl1	GO:0003674,GO:0003824,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872,GO:0047777,GO:0050083	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TLS3_k127_644815_0	272942.RCAP_rcc03165	1.162e-160	511.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria,1FANG@1060|Rhodobacter	28211|Alphaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
TLS3_k127_644815_4	1123247.AUIJ01000004_gene1104	1.551e-80	275.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-transferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_644815_5	1353528.DT23_05155	1.078e-72	264.0	COG2177@1|root,COG2177@2|Bacteria,1MXKQ@1224|Proteobacteria,2TSNT@28211|Alphaproteobacteria,2XKGM@285107|Thioclava	28211|Alphaproteobacteria	D	cell division protein	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
TLS3_k127_644815_3	1469613.JT55_09755	6.685e-89	297.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,3FD0X@34008|Rhodovulum	28211|Alphaproteobacteria	D	ATPases associated with a variety of cellular activities	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TLS3_k127_645097_4	1294273.roselon_03017	1.428e-28	118.0	COG1621@1|root,COG1621@2|Bacteria,1PIQ9@1224|Proteobacteria,2UCAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 68 family	sacB	GO:0005575,GO:0005576	2.4.1.10,3.2.1.26	ko:K00692,ko:K01193	ko00052,ko00500,ko01100,ko02020,map00052,map00500,map01100,map02020	-	R00801,R00802,R02410,R03635,R03921,R05140,R06088	RC00028,RC00077	ko00000,ko00001,ko01000,ko01003	-	GH32,GH68	-	Glyco_hydro_68
TLS3_k127_645097_0	935840.JAEQ01000021_gene4418	4.518e-105	346.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,2TRJZ@28211|Alphaproteobacteria,43M6P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
TLS3_k127_645097_2	1123237.Salmuc_00454	7.742e-73	255.0	COG0251@1|root,COG0251@2|Bacteria,1RAKQ@1224|Proteobacteria,2U5F4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS3_k127_645097_1	536019.Mesop_5990	1.05e-104	342.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS3_k127_645097_3	34007.IT40_25630	6.353e-70	239.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,2PWTN@265|Paracoccus	28211|Alphaproteobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS3_k127_6456155_1	1121033.AUCF01000006_gene4354	3.125e-13	73.0	COG4221@1|root,COG4221@2|Bacteria,1MUU6@1224|Proteobacteria,2TQW8@28211|Alphaproteobacteria,2JRCQ@204441|Rhodospirillales	204441|Rhodospirillales	S	short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_6456155_0	501479.ACNW01000076_gene1733	1.702e-204	647.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0433 Predicted ATPase	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
TLS3_k127_6460478_0	1123237.Salmuc_05639	2.522e-95	324.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	N-formylglutamate amidohydrolase	MA20_06380	-	3.5.1.68	ko:K01458	ko00340,ko00630,map00340,map00630	-	R00525	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	FGase
TLS3_k127_6460478_2	388401.RB2150_13246	2.779e-14	77.0	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,3ZHY3@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
TLS3_k127_6460478_1	1449351.RISW2_06245	1.609e-61	221.0	COG3409@1|root,COG4249@1|root,COG3409@2|Bacteria,COG4249@2|Bacteria,1PHZP@1224|Proteobacteria,2VA4X@28211|Alphaproteobacteria,4KKZC@93682|Roseivivax	28211|Alphaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS3_k127_6461534_0	1402135.SUH3_02855	3.163e-218	681.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,3ZV8Q@60136|Sulfitobacter	28211|Alphaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS3_k127_6461534_1	398580.Dshi_2135	1.416e-65	231.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_27940	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_6461534_2	1461694.ATO9_13085	2.071e-37	146.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,2PCSE@252301|Oceanicola	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
TLS3_k127_6483145_1	1417296.U879_02340	1.004e-126	418.0	COG1820@1|root,COG1820@2|Bacteria,1MW8Y@1224|Proteobacteria,2TRBT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	GO:0003674,GO:0003824,GO:0005488,GO:0006040,GO:0006044,GO:0006046,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008270,GO:0008448,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0016999,GO:0017001,GO:0017144,GO:0019213,GO:0019262,GO:0019752,GO:0022607,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
TLS3_k127_6483145_0	1185766.DL1_20250	3.169e-130	424.0	COG2222@1|root,COG2222@2|Bacteria,1MXC7@1224|Proteobacteria,2TUJY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM sugar isomerase (SIS)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
TLS3_k127_6484639_2	1530186.JQEY01000007_gene3159	2.559e-109	361.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TRCV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S11 family	dacF	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11,SPOR
TLS3_k127_6484639_6	1500301.JQMF01000006_gene1838	1.785e-11	71.0	COG5490@1|root,COG5490@2|Bacteria,1MZW0@1224|Proteobacteria,2UC4T@28211|Alphaproteobacteria,4BFRQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Phasin protein	MA20_36110	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
TLS3_k127_6484639_4	1294273.roselon_00665	3.428e-51	182.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS3_k127_6484639_3	1294273.roselon_00664	6.873e-71	258.0	COG2813@1|root,COG2813@2|Bacteria,1MXE9@1224|Proteobacteria,2TSBA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	16S RNA G1207 methylase RsmC	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS,MTS_N
TLS3_k127_6484639_5	1443111.JASG01000004_gene1556	1.069e-23	104.0	COG0694@1|root,COG0694@2|Bacteria,1N7QK@1224|Proteobacteria,2UG58@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6484639_0	195105.CN97_09645	4.16e-155	503.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_6484639_1	1121271.AUCM01000004_gene1184	5.702e-138	471.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_6491380_1	1105367.CG50_01345	7.137e-183	576.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
TLS3_k127_6491380_2	1392838.AWNM01000019_gene4061	3.863e-80	279.0	COG0657@1|root,COG0657@2|Bacteria,1MV3J@1224|Proteobacteria,2VNRV@28216|Betaproteobacteria	28216|Betaproteobacteria	I	esterase	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3,COesterase
TLS3_k127_6491380_0	1417296.U879_06340	5.532e-202	653.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	cckA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
TLS3_k127_6504113_3	1530186.JQEY01000003_gene2121	5.041e-41	153.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	glucose sorbosone	yliI	-	1.1.5.2	ko:K00117,ko:K21430	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	GSDH
TLS3_k127_6504113_2	89187.ISM_16230	5.375e-71	248.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria,46RES@74030|Roseovarius	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
TLS3_k127_6504113_1	420324.KI912086_gene7322	9.806e-141	452.0	COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,2TUJ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_6504113_0	1410620.SHLA_78c000050	7.036e-158	505.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2TR13@28211|Alphaproteobacteria,4B81W@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_6509709_0	1354722.JQLS01000008_gene1731	3.393e-226	709.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,46NJV@74030|Roseovarius	28211|Alphaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
TLS3_k127_6509709_3	1532558.JL39_05225	5.974e-115	402.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,2TR3E@28211|Alphaproteobacteria,4BB8C@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS3_k127_6509709_2	582402.Hbal_0541	1.018e-124	420.0	COG3011@1|root,COG3011@2|Bacteria,1PR4E@1224|Proteobacteria,2V0TE@28211|Alphaproteobacteria,43YT5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS3_k127_6509709_1	1502724.FF80_03031	9.124e-164	527.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,3N7NR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, YdiU/UPF0061 family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
TLS3_k127_6516403_3	1449350.OCH239_20825	2.481e-09	65.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2TR82@28211|Alphaproteobacteria,4KKQ4@93682|Roseivivax	28211|Alphaproteobacteria	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25,4.1.99.12	ko:K01497,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
TLS3_k127_6516403_0	1415756.JQMY01000001_gene276	1.719e-119	393.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2TR97@28211|Alphaproteobacteria,2PDGA@252301|Oceanicola	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	mtrA	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_6516403_1	349102.Rsph17025_3042	6.361e-105	348.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2TRTM@28211|Alphaproteobacteria,1FCQ5@1060|Rhodobacter	28211|Alphaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	ycgM	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0008948,GO:0016787,GO:0016822,GO:0016823,GO:0016829,GO:0016830,GO:0016831,GO:0018773,GO:0031974,GO:0031981,GO:0034545,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
TLS3_k127_6516403_2	1469613.JT55_00240	8.877e-45	178.0	COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,2UCHH@28211|Alphaproteobacteria,3FDI3@34008|Rhodovulum	28211|Alphaproteobacteria	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD,FlgD_ig
TLS3_k127_6516403_4	1161401.ASJA01000003_gene2890	2.614e-09	65.0	COG3144@1|root,COG3144@2|Bacteria,1N7X4@1224|Proteobacteria,2UF9W@28211|Alphaproteobacteria,43YRS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	N	Flagellar hook-length control protein FliK	-	-	-	ko:K02414,ko:K10565	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
TLS3_k127_6523238_0	1105367.CG50_12550	9.091e-128	415.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TTE1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
TLS3_k127_6523238_1	1547437.LL06_12850	2.786e-66	245.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2U27Q@28211|Alphaproteobacteria,43RTX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_6523238_3	570967.JMLV01000010_gene1211	2.479e-23	111.0	COG4338@1|root,COG4338@2|Bacteria,1N3G5@1224|Proteobacteria,2UATJ@28211|Alphaproteobacteria,2JTEC@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6523238_2	1397666.RS24_00445	1.041e-24	109.0	COG3806@1|root,COG3806@2|Bacteria,1RI6T@1224|Proteobacteria,2TVH9@28211|Alphaproteobacteria,4BQQN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	ChrR Cupin-like domain	chrR	-	-	ko:K07167	-	-	-	-	ko00000	-	-	-	Cupin_7,zf-HC2
TLS3_k127_6544267_1	936455.KI421499_gene1791	1.085e-117	391.0	COG1503@1|root,COG1503@2|Bacteria,1MXX2@1224|Proteobacteria,2U2KZ@28211|Alphaproteobacteria,3JS95@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6544267_0	1525715.IX54_08775	8.624e-203	640.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,2PW6C@265|Paracoccus	28211|Alphaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_6544267_2	349102.Rsph17025_0648	3.885e-116	393.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria,1FBAB@1060|Rhodobacter	28211|Alphaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS3_k127_6544267_4	1469613.JT55_12000	1.012e-35	154.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria,3FDJ8@34008|Rhodovulum	28211|Alphaproteobacteria	G	haloacid dehalogenase-like hydrolase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_6544267_3	1417296.U879_13875	7.616e-56	207.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,2U5T9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
TLS3_k127_6544267_5	1101189.AQUO01000001_gene1730	4.439e-10	66.0	COG1539@1|root,COG1539@2|Bacteria,1MY5Q@1224|Proteobacteria,2TRVX@28211|Alphaproteobacteria,2PUI1@265|Paracoccus	28211|Alphaproteobacteria	H	Dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	4HFCP_synth,FolB
TLS3_k127_6563531_0	1469613.JT55_06530	0.0	1515.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,3FCKA@34008|Rhodovulum	28211|Alphaproteobacteria	KL	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS3_k127_6621940_0	314271.RB2654_06257	8.973e-104	347.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS3_k127_6621940_3	644107.SL1157_0026	3.485e-29	123.0	COG4731@1|root,COG4731@2|Bacteria,1RHN9@1224|Proteobacteria,2U9SP@28211|Alphaproteobacteria,4NC8Z@97050|Ruegeria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
TLS3_k127_6621940_4	405948.SACE_3008	3.602e-08	65.0	COG4319@1|root,COG4319@2|Bacteria,2IRHC@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS3_k127_6621940_2	314232.SKA53_07366	7.854e-81	287.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,2P88P@245186|Loktanella	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS3_k127_6621940_1	1123501.KB902315_gene3310	2.41e-92	306.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.9,3.1.3.15,4.2.1.19	ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03013,R03243,R03457	RC00006,RC00017,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	IGPD
TLS3_k127_6629217_0	195105.CN97_10995	3.118e-149	477.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS3_k127_6629217_1	292414.TM1040_2074	9.042e-68	238.0	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2U07P@28211|Alphaproteobacteria,4N9XS@97050|Ruegeria	28211|Alphaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	nahD	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS3_k127_6658880_10	1123501.KB902313_gene2923	2.47e-34	135.0	COG3568@1|root,COG3568@2|Bacteria,1QV2C@1224|Proteobacteria,2U065@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_6658880_1	1317124.DW2_09211	1.297e-193	609.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,2XM6M@285107|Thioclava	28211|Alphaproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS3_k127_6658880_4	1469613.JT55_07570	5.798e-125	407.0	COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,2V86R@28211|Alphaproteobacteria,3FDVH@34008|Rhodovulum	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_6658880_2	1125973.JNLC01000016_gene2868	1.193e-180	585.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,2TSZJ@28211|Alphaproteobacteria,3JR2B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Transporter associated domain	cvrA	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	CorC_HlyC,Na_H_Exchanger
TLS3_k127_6658880_12	1057002.KB905370_gene1723	2.915e-05	54.0	COG4961@1|root,COG4961@2|Bacteria,1N10I@1224|Proteobacteria,2UG9G@28211|Alphaproteobacteria,4BHNV@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS3_k127_6658880_11	266779.Meso_0608	6.245e-14	77.0	COG4961@1|root,COG4963@1|root,COG4961@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,43H2T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	AAA domain	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,TadE
TLS3_k127_6658880_7	1530186.JQEY01000010_gene2761	1.153e-88	306.0	COG4655@1|root,COG4655@2|Bacteria,1RGJG@1224|Proteobacteria,2U32U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS3_k127_6658880_3	266809.PM03_06445	1.155e-132	427.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS3_k127_6658880_6	1337093.MBE-LCI_2257	1.011e-92	312.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria,2P8J7@245186|Loktanella	28211|Alphaproteobacteria	S	Probable molybdopterin binding domain	cinA1	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
TLS3_k127_6658880_8	1294273.roselon_00255	2.287e-38	148.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2U95K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	MA20_41450	-	-	-	-	-	-	-	-	-	-	-	DUF498
TLS3_k127_6658880_5	314264.ROS217_21812	2.062e-97	329.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,46P1R@74030|Roseovarius	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS3_k127_6658880_0	1122180.Lokhon_01698	3.691e-224	707.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2P8HP@245186|Loktanella	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS3_k127_6658880_9	349102.Rsph17025_0455	1.988e-37	146.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,1FC2Q@1060|Rhodobacter	28211|Alphaproteobacteria	U	TIGRFAM preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS3_k127_6679406_3	272943.RSP_0890	3.516e-35	142.0	COG2854@1|root,COG2854@2|Bacteria,1PDBV@1224|Proteobacteria,2U5HR@28211|Alphaproteobacteria,1FBU7@1060|Rhodobacter	28211|Alphaproteobacteria	Q	PFAM toluene tolerance	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
TLS3_k127_6679406_2	1123360.thalar_03136	1.084e-55	205.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	(Lipo)protein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
TLS3_k127_6679406_1	272943.RSP_0894	4.809e-64	224.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,1FBRX@1060|Rhodobacter	28211|Alphaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS3_k127_6679406_0	314256.OG2516_12391	3.538e-88	299.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2TV1D@28211|Alphaproteobacteria,2PCHG@252301|Oceanicola	28211|Alphaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
TLS3_k127_6679406_4	469383.Cwoe_0449	3.097e-26	118.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria,4CTPZ@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
TLS3_k127_6682791_1	123899.JPQP01000004_gene340	7.664e-17	89.0	2EB92@1|root,3359J@2|Bacteria,1N8U0@1224|Proteobacteria,2W8UN@28216|Betaproteobacteria,3T78J@506|Alcaligenaceae	28216|Betaproteobacteria	S	PhoP regulatory network protein YrbL	-	-	-	-	-	-	-	-	-	-	-	-	YrbL-PhoP_reg
TLS3_k127_6682791_0	216596.RL3573A	1.55e-18	92.0	2DDPZ@1|root,2ZIV2@2|Bacteria,1NJY3@1224|Proteobacteria,2UK1B@28211|Alphaproteobacteria,4BEJ6@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6703353_3	1187851.A33M_2350	2.878e-16	83.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria,2UF5P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_6703353_0	1123237.Salmuc_02793	1.685e-161	527.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family'	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
TLS3_k127_6703353_2	1417296.U879_04275	2.15e-85	290.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
TLS3_k127_6703353_1	631454.N177_2171	3.283e-93	312.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,1JPXN@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	SAF	MA20_06800	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
TLS3_k127_6722395_4	1120956.JHZK01000030_gene16	9.339e-71	256.0	COG2304@1|root,COG2304@2|Bacteria,1RA4S@1224|Proteobacteria,2U5T8@28211|Alphaproteobacteria,1JNRF@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6722395_3	1123229.AUBC01000014_gene2939	1.214e-115	392.0	COG2319@1|root,COG3474@1|root,COG2319@2|Bacteria,COG3474@2|Bacteria,1MWJA@1224|Proteobacteria,2TRIX@28211|Alphaproteobacteria,3JS61@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	WD domain, G-beta repeat	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,WD40
TLS3_k127_6722395_1	441620.Mpop_1891	2.314e-162	535.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,1JRJU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	MA20_36630	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
TLS3_k127_6722395_0	1354722.JQLS01000008_gene582	1.018e-208	662.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TSTS@28211|Alphaproteobacteria,46NPQ@74030|Roseovarius	28211|Alphaproteobacteria	P	COG1178 ABC-type Fe3 transport system, permease component	sfuB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS3_k127_6722395_2	1089551.KE386572_gene1647	2.375e-128	418.0	COG2376@1|root,COG2376@2|Bacteria,1MVSR@1224|Proteobacteria,2TTK3@28211|Alphaproteobacteria,4BRC7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Dak1 domain	dhaK	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
TLS3_k127_6722395_5	1168059.KB899087_gene3287	3.298e-23	108.0	2CEM6@1|root,31A6G@2|Bacteria,1PV1R@1224|Proteobacteria,2V6IS@28211|Alphaproteobacteria,3F1F3@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6722395_6	936455.KI421499_gene3704	2.307e-14	75.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2TR28@28211|Alphaproteobacteria,3JUNN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS3_k127_6739225_0	1122180.Lokhon_02191	3.137e-88	310.0	COG3524@1|root,COG3524@2|Bacteria,1R3ZY@1224|Proteobacteria,2U0I2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG3524 Capsule polysaccharide export protein	kpsE	-	-	ko:K10107	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.101	-	-	-
TLS3_k127_6739225_2	1121271.AUCM01000007_gene3822	5.909e-71	259.0	COG1682@1|root,COG1682@2|Bacteria,1MUTE@1224|Proteobacteria,2U29Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component	kpsM	-	-	ko:K09688	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.101	-	-	ABC2_membrane
TLS3_k127_6739225_3	1279019.ARQK01000027_gene2457	2.023e-56	217.0	COG0463@1|root,COG0463@2|Bacteria,1R7V3@1224|Proteobacteria,1S0CE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyltransferases involved in cell wall biogenesis	wceM	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_6739225_1	391937.NA2_18465	5.656e-73	272.0	COG1216@1|root,COG1216@2|Bacteria,1R5GW@1224|Proteobacteria,2TTEN@28211|Alphaproteobacteria,43M8U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
TLS3_k127_6739225_4	1123501.KB902286_gene2040	8.865e-35	148.0	2E81Q@1|root,332FR@2|Bacteria,1ND2Z@1224|Proteobacteria,2UHIA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6745050_0	1449351.RISW2_12675	2.412e-158	508.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,4KM6F@93682|Roseivivax	28211|Alphaproteobacteria	I	Acetyl-CoA dehydrogenase C-terminal like	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS3_k127_6745050_1	1123247.AUIJ01000013_gene2443	3.672e-101	338.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS3_k127_6745050_2	388401.RB2150_10384	5.703e-70	245.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,3ZHE3@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	MA20_18155	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
TLS3_k127_6747063_1	349102.Rsph17025_2270	3.193e-219	693.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
TLS3_k127_6747063_3	1461694.ATO9_15415	7.76e-55	198.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,2PDYP@252301|Oceanicola	28211|Alphaproteobacteria	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	ccmG	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
TLS3_k127_6747063_5	1449351.RISW2_07495	0.0001665	53.0	COG3114@1|root,COG3114@2|Bacteria,1NGTN@1224|Proteobacteria,2UJD6@28211|Alphaproteobacteria,4KN40@93682|Roseivivax	28211|Alphaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmD	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
TLS3_k127_6747063_2	1121271.AUCM01000003_gene1532	1.86e-119	387.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
TLS3_k127_6747063_4	1158318.ATXC01000001_gene948	9.651e-07	52.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_2,TonB_C
TLS3_k127_6747063_0	1415756.JQMY01000001_gene2275	0.0	1004.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2PDMF@252301|Oceanicola	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4445)	nqrF	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
TLS3_k127_6769467_4	1121271.AUCM01000003_gene1495	3.561e-15	76.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
TLS3_k127_6769467_2	766499.C357_05832	9.517e-122	401.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS3_k127_6769467_3	89187.ISM_01970	6.027e-66	235.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,46P8W@74030|Roseovarius	28211|Alphaproteobacteria	S	SOS response associated peptidase (SRAP)	MA20_42060	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS3_k127_6769467_0	398580.Dshi_0849	1.3e-183	592.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TTUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the 5'-nucleotidase family	MA20_07595	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006213,GO:0006259,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007155,GO:0007159,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009164,GO:0009166,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019362,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0022610,GO:0031974,GO:0031981,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046135,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0072524,GO:0072527,GO:0072529,GO:0090304,GO:0098609,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,LysM,Metallophos
TLS3_k127_6769467_1	991905.SL003B_3287	1.928e-167	540.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,4BPXD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.96	ko:K16871	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R10178	RC00008,RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_3
TLS3_k127_6769467_6	1121938.AUDY01000007_gene2501	0.0004688	46.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6769467_5	1423144.Gal_00445	7.52e-11	68.0	COG0582@1|root,COG0582@2|Bacteria,1R3TM@1224|Proteobacteria,2TS94@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
TLS3_k127_678590_6	314232.SKA53_11613	1.831e-06	55.0	29724@1|root,2ZUAH@2|Bacteria,1RGP1@1224|Proteobacteria,2U8AW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_678590_4	396595.TK90_1671	6.173e-58	224.0	COG3971@1|root,COG3971@2|Bacteria,1R3UP@1224|Proteobacteria,1SES7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	hydratase decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_678590_2	716928.AJQT01000025_gene3997	2.106e-116	382.0	COG1524@1|root,COG1524@2|Bacteria,1MYH0@1224|Proteobacteria,2TT65@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	proteins of the AP superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS3_k127_678590_3	935565.JAEM01000018_gene1066	8.38e-67	247.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2U5X1@28211|Alphaproteobacteria,2PVT3@265|Paracoccus	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
TLS3_k127_678590_0	1449065.JMLL01000013_gene2866	2.547e-254	794.0	COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2TS4U@28211|Alphaproteobacteria,43J7P@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS3_k127_678590_1	1381123.AYOD01000047_gene247	3.318e-151	483.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSIY@28211|Alphaproteobacteria,43IIF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_678590_5	935261.JAGL01000006_gene2255	2.012e-21	107.0	COG1173@1|root,COG1173@2|Bacteria,1MU0P@1224|Proteobacteria,2TSX5@28211|Alphaproteobacteria,43II6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS3_k127_6804952_3	1105367.CG50_05285	4.721e-25	111.0	COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,2TRZ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
TLS3_k127_6804952_1	1185766.DL1_14685	1.365e-63	222.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,2U98X@28211|Alphaproteobacteria,2XNJS@285107|Thioclava	28211|Alphaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobP	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
TLS3_k127_6804952_4	441620.Mpop_2087	8.473e-18	93.0	COG1872@1|root,COG1872@2|Bacteria,1PMJY@1224|Proteobacteria,2V06N@28211|Alphaproteobacteria,1JVIA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS3_k127_6804952_0	1461694.ATO9_16785	5.1e-164	524.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TSBY@28211|Alphaproteobacteria,2PCDP@252301|Oceanicola	28211|Alphaproteobacteria	E	CO dehydrogenase/acetyl-CoA synthase delta subunit	acsE	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS3_k127_6804952_2	1317118.ATO8_07961	1.55e-60	219.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2U52Q@28211|Alphaproteobacteria,4KMJU@93682|Roseivivax	28211|Alphaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_6804952_5	1294273.roselon_03048	7.39e-16	78.0	COG0685@1|root,COG0685@2|Bacteria,1MVWT@1224|Proteobacteria,2TTSF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0685 5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_6810144_0	1120983.KB894575_gene715	1.479e-106	351.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,1JQ0B@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
TLS3_k127_6810144_1	1122214.AQWH01000006_gene2325	1.464e-43	173.0	COG1309@1|root,COG1309@2|Bacteria,1NX24@1224|Proteobacteria,2USNK@28211|Alphaproteobacteria,2PM1Q@255475|Aurantimonadaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_6819817_2	1121479.AUBS01000002_gene3614	9.133e-48	184.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2U75R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS3_k127_6819817_1	388401.RB2150_15690	7.425e-85	289.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2TV8S@28211|Alphaproteobacteria,3ZG15@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS3_k127_6819817_0	1569209.BBPH01000155_gene1763	4.826e-209	656.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,2PVME@265|Paracoccus	28211|Alphaproteobacteria	IQ	catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS3_k127_6819817_3	1122963.AUHB01000007_gene3728	6.065e-36	139.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,36XMN@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_6855034_0	1122614.JHZF01000011_gene818	3.53e-307	957.0	COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,2PDJ7@252301|Oceanicola	28211|Alphaproteobacteria	L	helicase superfamily c-terminal domain	mgpS	-	3.6.4.13	ko:K17675	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C
TLS3_k127_6856091_0	272943.RSP_2679	2.292e-167	538.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS3_k127_6856091_2	1122963.AUHB01000001_gene586	5.438e-26	111.0	COG3729@1|root,COG3729@2|Bacteria,1NH1J@1224|Proteobacteria,2VGGJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Stress-induced bacterial acidophilic repeat motif	-	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	KGG
TLS3_k127_6856091_1	1336249.JADW01000026_gene4594	5.042e-26	116.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2U5JM@28211|Alphaproteobacteria,4BJAJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_6879862_0	1125973.JNLC01000016_gene2868	1.801e-97	330.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,2TSZJ@28211|Alphaproteobacteria,3JR2B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Transporter associated domain	cvrA	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	CorC_HlyC,Na_H_Exchanger
TLS3_k127_6879862_1	391595.RLO149_c033000	3.296e-14	79.0	COG1525@1|root,COG1525@2|Bacteria,1Q36Y@1224|Proteobacteria,2VA6A@28211|Alphaproteobacteria,2P568@2433|Roseobacter	28211|Alphaproteobacteria	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	SNase
TLS3_k127_6910836_2	395961.Cyan7425_5147	4.04e-21	108.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Metallophos
TLS3_k127_6910836_0	375451.RD1_1635	0.0	1018.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2P10R@2433|Roseobacter	28211|Alphaproteobacteria	I	COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit	mutB	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS3_k127_6910836_1	314271.RB2654_09034	1.576e-45	167.0	COG0604@1|root,COG0604@2|Bacteria,1MXIK@1224|Proteobacteria,2TQPR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	ccrA	-	1.1.1.1,1.3.1.85	ko:K00001,ko:K14446	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	M00373	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R09291	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_69509_3	1402135.SUH3_03220	7.551e-30	122.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,2U940@28211|Alphaproteobacteria,3ZY60@60136|Sulfitobacter	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS3_k127_69509_1	864069.MicloDRAFT_00028240	1.497e-52	191.0	COG0431@1|root,COG0431@2|Bacteria,1RDFK@1224|Proteobacteria,2U70M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS3_k127_69509_4	318586.Pden_4580	2.078e-24	106.0	COG0431@1|root,COG2329@1|root,COG0431@2|Bacteria,COG2329@2|Bacteria,1MXQ8@1224|Proteobacteria,2TRI5@28211|Alphaproteobacteria,2PV41@265|Paracoccus	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS3_k127_69509_0	371731.Rsw2DRAFT_2224	1.283e-139	455.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,1FANK@1060|Rhodobacter	28211|Alphaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS3_k127_69509_5	1188256.BASI01000002_gene3280	1.691e-19	102.0	2E3KZ@1|root,32YJ8@2|Bacteria,1N7A7@1224|Proteobacteria,2UFMR@28211|Alphaproteobacteria,3FDGD@34008|Rhodovulum	28211|Alphaproteobacteria	S	Putative prokaryotic signal transducing protein	MA20_42240	-	-	-	-	-	-	-	-	-	-	-	DUF2007
TLS3_k127_69509_2	1353537.TP2_08455	4.688e-51	187.0	COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,2TUBR@28211|Alphaproteobacteria,2XMUY@285107|Thioclava	28211|Alphaproteobacteria	J	Methyltransferase domain	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS
TLS3_k127_695403_0	759362.KVU_2413	3.995e-137	443.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2U25R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS3_k127_695403_1	1410620.SHLA_10c000450	4.629e-99	332.0	COG2207@1|root,COG2207@2|Bacteria,1MXT9@1224|Proteobacteria,2U0UP@28211|Alphaproteobacteria,4BJ46@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	AraC-binding-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
TLS3_k127_695403_2	1381123.AYOD01000028_gene390	6.595e-21	107.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,43NTP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS3_k127_695403_3	991905.SL003B_0728	2.65e-18	83.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EQ	N-methylhydantoinase B acetone carboxylase alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
TLS3_k127_6966620_1	1353537.TP2_01950	4.944e-135	458.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,2XMIQ@285107|Thioclava	28211|Alphaproteobacteria	E	Gamma-glutamylputrescine oxidoreductase	puuB	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
TLS3_k127_6966620_4	1101189.AQUO01000002_gene621	2.62e-10	65.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria,2PY33@265|Paracoccus	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	puuB	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
TLS3_k127_6966620_2	1082931.KKY_2864	2.622e-124	427.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,3N685@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
TLS3_k127_6966620_0	1082931.KKY_2864	1.616e-139	453.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria,3N685@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K11073	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
TLS3_k127_6966620_3	349521.HCH_00809	1.187e-90	325.0	COG0784@1|root,COG2198@1|root,COG3452@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG3452@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XRVZ@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_6973680_9	439497.RR11_3615	5.126e-17	87.0	2E8MM@1|root,332Z2@2|Bacteria,1N74Q@1224|Proteobacteria,2UFS8@28211|Alphaproteobacteria,4NCPF@97050|Ruegeria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6973680_0	1443111.JASG01000004_gene2910	1.163e-219	691.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,3ZUVS@60136|Sulfitobacter	28211|Alphaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS3_k127_6973680_8	999141.GME_14173	1.085e-18	91.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1S08P@1236|Gammaproteobacteria,1XN50@135619|Oceanospirillales	135619|Oceanospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS3_k127_6973680_2	1188256.BASI01000003_gene2814	8.016e-161	530.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,3FCRF@34008|Rhodovulum	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS3_k127_6973680_5	1353528.DT23_07135	7.763e-71	263.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,2TUIK@28211|Alphaproteobacteria,2XMCQ@285107|Thioclava	28211|Alphaproteobacteria	J	GCN5 family	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS3_k127_6973680_3	1294273.roselon_00057	3.14e-159	535.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the peptidase M16 family	mpp	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_6973680_1	272943.RSP_1831	5.552e-188	615.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,1FB93@1060|Rhodobacter	28211|Alphaproteobacteria	H	TIGRFAM threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
TLS3_k127_6973680_6	571166.KI421509_gene3566	7.541e-58	222.0	COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Surf1-like protein	surf1	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
TLS3_k127_6973680_4	1123501.KB902282_gene2427	1.071e-145	466.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	heme copper-type cytochrome quinol oxidase, subunit 3	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
TLS3_k127_6973680_7	349102.Rsph17025_0617	5.378e-57	205.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
TLS3_k127_6973680_11	1121271.AUCM01000004_gene1193	3.057e-13	72.0	2EFUR@1|root,339KW@2|Bacteria,1NHGF@1224|Proteobacteria,2UJKN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cytochrome C oxidase assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6973680_10	266809.PM03_02070	1.509e-16	80.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS3_k127_6975686_4	648757.Rvan_0999	1.055e-58	208.0	294R4@1|root,2ZS4D@2|Bacteria,1RDGM@1224|Proteobacteria,2U71V@28211|Alphaproteobacteria,3N8TR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	2-vinyl bacteriochlorophyllide hydratase (BCHF)	bchF	GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.165	ko:K11336	ko00860,ko01110,map00860,map01110	-	R09054,R09059	RC02412	ko00000,ko00001,ko01000	-	-	-	BCHF
TLS3_k127_6975686_2	398580.Dshi_3534	2.968e-213	678.0	COG2710@1|root,COG2710@2|Bacteria,1MVP0@1224|Proteobacteria,2TSK1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex	bchN	-	1.3.7.7	ko:K04038	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06282	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro
TLS3_k127_6975686_1	1449351.RISW2_22515	4.029e-244	784.0	COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,2TSTQ@28211|Alphaproteobacteria,4KKQ1@93682|Roseivivax	28211|Alphaproteobacteria	F	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex	bchB	-	1.3.7.7	ko:K04039	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06282	RC01008	ko00000,ko00001,ko01000	-	-	-	Oxidored_nitro,PCP_red
TLS3_k127_6975686_0	1120956.JHZK01000006_gene659	0.0	1547.0	COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,2TQVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases	bchH	-	6.6.1.1	ko:K03403	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,DUF3479
TLS3_k127_6975686_3	398580.Dshi_3537	2.235e-168	534.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2TSKC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP	bchL	-	1.3.7.7	ko:K04037	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06282	RC01008	ko00000,ko00001,ko01000	-	-	-	Fer4_NifH
TLS3_k127_6975686_5	1449350.OCH239_19540	2.097e-20	96.0	COG2227@1|root,COG2227@2|Bacteria,1N2VZ@1224|Proteobacteria,2TU4Z@28211|Alphaproteobacteria,4KM13@93682|Roseivivax	28211|Alphaproteobacteria	H	Magnesium-protoporphyrin IX methyltransferase C-terminus	bchM	GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	MTS,Mg-por_mtran_C,PrmA
TLS3_k127_6985143_8	195105.CN97_18175	4.717e-17	89.0	2DP1J@1|root,3305M@2|Bacteria,1N92M@1224|Proteobacteria,2UHF3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6985143_5	670292.JH26_01905	2.553e-26	119.0	COG3266@1|root,COG3266@2|Bacteria,1NC0S@1224|Proteobacteria,2UG0A@28211|Alphaproteobacteria,1JWRG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6985143_2	633131.TR2A62_1410	1.198e-59	221.0	COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2U9HD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	carbon monoxide dehydrogenase	coxG	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS3_k127_6985143_7	644107.SL1157_2300	2.177e-17	88.0	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2UBV0@28211|Alphaproteobacteria,4NCGS@97050|Ruegeria	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
TLS3_k127_6985143_9	272942.RCAP_rcc01968	2.683e-05	55.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2TRCS@28211|Alphaproteobacteria,1FB55@1060|Rhodobacter	28211|Alphaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS3_k127_6985143_1	1469613.JT55_06740	7.336e-80	284.0	COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria,3FD9N@34008|Rhodovulum	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_6985143_3	1449351.RISW2_20890	6.527e-45	177.0	COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,4KMM3@93682|Roseivivax	28211|Alphaproteobacteria	O	Disulfide bond formation protein DsbB	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
TLS3_k127_6985143_0	246200.SPO2123	3.681e-94	313.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,4NAYJ@97050|Ruegeria	28211|Alphaproteobacteria	L	HNH endonuclease	MA20_20605	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
TLS3_k127_6985143_4	1367847.JCM7686_2054	2.969e-38	146.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2TTWP@28211|Alphaproteobacteria,2PWDW@265|Paracoccus	28211|Alphaproteobacteria	S	Phospholipase/Carboxylesterase	estB	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS3_k127_700737_3	426117.M446_2144	8.886e-118	385.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2TSZ0@28211|Alphaproteobacteria,1JTKG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	PFAM amidohydrolase	-	-	3.5.4.32	ko:K18456	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_1
TLS3_k127_700737_1	349102.Rsph17025_3035	1.038e-220	707.0	COG0726@1|root,COG3195@1|root,COG0726@2|Bacteria,COG3195@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,1FBB9@1060|Rhodobacter	28211|Alphaproteobacteria	G	polysaccharide deacetylase	-	-	3.5.1.41	ko:K01452	ko00520,ko01100,map00520,map01100	-	R02333	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	OHCU_decarbox,Polysacc_deac_1
TLS3_k127_700737_4	1317118.ATO8_13427	2.764e-48	177.0	COG2351@1|root,COG2351@2|Bacteria,1RH84@1224|Proteobacteria,2U9IT@28211|Alphaproteobacteria,4KMUA@93682|Roseivivax	28211|Alphaproteobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
TLS3_k127_700737_0	272943.RSP_0240	3.379e-237	761.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,1FBKP@1060|Rhodobacter	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
TLS3_k127_700737_2	1121028.ARQE01000007_gene3881	2.43e-136	440.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,2PJAY@255475|Aurantimonadaceae	28211|Alphaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS3_k127_7016991_3	314271.RB2654_20208	7.556e-15	78.0	COG0644@1|root,COG0644@2|Bacteria,1RAS8@1224|Proteobacteria,2U5PA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_3,NAD_binding_8,Pyr_redox_2
TLS3_k127_7016991_1	1370122.JHXQ01000005_gene3485	5.114e-42	157.0	COG3546@1|root,COG3546@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria,4BD7C@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	DUF892,Mn_catalase
TLS3_k127_7016991_4	754035.Mesau_02569	4.108e-07	57.0	COG3546@1|root,COG3546@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria,43JY3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	PFAM Manganese containing catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
TLS3_k127_7016991_2	349102.Rsph17025_0606	5.607e-41	154.0	COG3546@1|root,COG3546@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
TLS3_k127_7016991_0	269796.Rru_A3015	4.914e-82	286.0	COG0687@1|root,COG0687@2|Bacteria,1PRWU@1224|Proteobacteria,2U2MI@28211|Alphaproteobacteria,2JQQG@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
TLS3_k127_7018358_0	371731.Rsw2DRAFT_2278	5.898e-104	346.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2TTI4@28211|Alphaproteobacteria,1FBDC@1060|Rhodobacter	28211|Alphaproteobacteria	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS3_k127_7018358_1	1469613.JT55_15840	5.586e-45	180.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,3FDDU@34008|Rhodovulum	28211|Alphaproteobacteria	G	PTS system fructose IIA component	manX	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
TLS3_k127_7018358_3	371731.Rsw2DRAFT_2280	1.275e-32	128.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2UC0H@28211|Alphaproteobacteria,1FC0E@1060|Rhodobacter	28211|Alphaproteobacteria	H	phosphocarrier, HPr	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TLS3_k127_7018358_2	1123229.AUBC01000001_gene1567	1.146e-41	157.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2TUIH@28211|Alphaproteobacteria,3JR8S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	WHG domain	MA20_04045	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS3_k127_7019632_0	1144310.PMI07_005405	8.015e-160	512.0	COG1015@1|root,COG1015@2|Bacteria,1MVN8@1224|Proteobacteria,2TRMP@28211|Alphaproteobacteria,4BITV@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
TLS3_k127_7019632_1	644107.SL1157_2172	3.358e-102	359.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2TSBX@28211|Alphaproteobacteria,4NBSE@97050|Ruegeria	28211|Alphaproteobacteria	F	Adenosine/AMP deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS3_k127_7019632_2	1449351.RISW2_13095	4.372e-101	349.0	COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,2TRS7@28211|Alphaproteobacteria,4KMDH@93682|Roseivivax	28211|Alphaproteobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS3_k127_7019632_3	1246995.AFR_17265	4.085e-08	55.0	COG0730@1|root,COG0730@2|Bacteria,2HNU1@201174|Actinobacteria,4DJ8J@85008|Micromonosporales	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_7033569_5	991905.SL003B_0351	9.743e-45	164.0	COG0347@1|root,COG0347@2|Bacteria,1RIRQ@1224|Proteobacteria,2UA55@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	nitrogen regulatory protein PII	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
TLS3_k127_7033569_2	83219.PM02_07395	1.034e-126	413.0	COG3329@1|root,COG3329@2|Bacteria,1N85P@1224|Proteobacteria,2TRK2@28211|Alphaproteobacteria,3ZW00@60136|Sulfitobacter	28211|Alphaproteobacteria	S	Na+-dependent bicarbonate transporter superfamily	-	-	-	ko:K07086	-	-	-	-	ko00000	-	-	-	Sbt_1
TLS3_k127_7033569_4	314256.OG2516_09790	3.082e-62	228.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria,2PDH3@252301|Oceanicola	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS3_k127_7033569_6	89187.ISM_02355	4.968e-05	51.0	2C1XR@1|root,32T89@2|Bacteria,1N1HY@1224|Proteobacteria,2UCII@28211|Alphaproteobacteria,46R01@74030|Roseovarius	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7033569_1	1432050.IE4771_CH01352	7.003e-149	475.0	COG1028@1|root,COG1028@2|Bacteria,1MVKN@1224|Proteobacteria,2TTMH@28211|Alphaproteobacteria,4B8TB@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS3_k127_7033569_3	331869.BAL199_17678	2.228e-64	225.0	COG1309@1|root,COG1309@2|Bacteria,1RFRF@1224|Proteobacteria,2U8ES@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_7033569_0	246200.SPO2078	2.649e-178	569.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,4NAF8@97050|Ruegeria	28211|Alphaproteobacteria	S	Penicillin amidase	quiP	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS3_k127_705998_3	991905.SL003B_0169	4.866e-170	546.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,4BRIE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	acsA2	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_705998_12	398580.Dshi_1819	6.238e-36	147.0	COG2197@1|root,COG2197@2|Bacteria,1RFWB@1224|Proteobacteria,2U8BA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG2771 DNA-binding HTH domain-containing proteins	-	-	-	ko:K07782,ko:K19731	ko02020,ko02024,ko02026,map02020,map02024,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
TLS3_k127_705998_7	398580.Dshi_1291	5.956e-77	273.0	COG4912@1|root,COG4912@2|Bacteria,1NKDG@1224|Proteobacteria,2TU19@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS3_k127_705998_8	371731.Rsw2DRAFT_0744	3.673e-73	251.0	COG3576@1|root,COG3576@2|Bacteria,1R8RC@1224|Proteobacteria,2TUXH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS3_k127_705998_1	1417296.U879_18195	1.207e-245	772.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
TLS3_k127_705998_2	1121271.AUCM01000003_gene1570	1.43e-172	552.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
TLS3_k127_705998_10	195105.CN97_03105	9.235e-68	247.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_705998_6	371731.Rsw2DRAFT_1699	1.149e-89	302.0	28NX2@1|root,2ZBUV@2|Bacteria,1RD3N@1224|Proteobacteria,2U89D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_705998_0	1122180.Lokhon_01212	8.058e-251	793.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,2P9F5@245186|Loktanella	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_705998_11	1530186.JQEY01000004_gene2103	1.373e-57	228.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
TLS3_k127_705998_4	1469613.JT55_11545	4.022e-158	509.0	COG0477@1|root,COG0477@2|Bacteria,1QTUM@1224|Proteobacteria,2TVX9@28211|Alphaproteobacteria,3FEMV@34008|Rhodovulum	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_705998_5	1188256.BASI01000003_gene2499	1.269e-137	447.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2TS0D@28211|Alphaproteobacteria,3FCRR@34008|Rhodovulum	28211|Alphaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
TLS3_k127_705998_13	1317124.DW2_17330	1.205e-27	119.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2U5DE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
TLS3_k127_705998_9	1231392.OCGS_1559	1.597e-72	246.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
TLS3_k127_7074260_0	398580.Dshi_1469	2.696e-190	601.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_7074260_2	1317124.DW2_15935	1.507e-139	471.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,2XKIH@285107|Thioclava	28211|Alphaproteobacteria	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS3_k127_7074260_1	1123237.Salmuc_02286	3.208e-163	524.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
TLS3_k127_7074260_3	246200.SPO1987	1.448e-42	163.0	COG1670@1|root,COG1670@2|Bacteria,1N6Q1@1224|Proteobacteria,2UG72@28211|Alphaproteobacteria,4NAZT@97050|Ruegeria	28211|Alphaproteobacteria	J	Acetyltransferase, gnat family	MA20_44020	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_7074260_4	1122180.Lokhon_01781	1.121e-37	141.0	COG0211@1|root,COG0211@2|Bacteria,1PTF9@1224|Proteobacteria,2VAH2@28211|Alphaproteobacteria,2P96A@245186|Loktanella	28211|Alphaproteobacteria	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS3_k127_7081900_2	1207063.P24_09916	4.617e-98	328.0	COG0702@1|root,COG0702@2|Bacteria,1N8V3@1224|Proteobacteria,2TYI8@28211|Alphaproteobacteria,2JTPW@204441|Rhodospirillales	204441|Rhodospirillales	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS3_k127_7081900_6	195105.CN97_10720	2.779e-09	62.0	2DNVR@1|root,32ZDF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7081900_5	350058.Mvan_3415	3.991e-60	223.0	COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae	201174|Actinobacteria	IK	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Trans_reg_C
TLS3_k127_7081900_3	398580.Dshi_1070	1.029e-92	308.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
TLS3_k127_7081900_4	582899.Hden_2748	1.257e-91	311.0	COG3258@1|root,COG3258@2|Bacteria,1NIQK@1224|Proteobacteria,2U0YV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome c class I	-	-	1.8.2.2	ko:K19713	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrom_C,Cytochrome_CBB3
TLS3_k127_7081900_1	272942.RCAP_rcc02175	1.178e-119	409.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,2TVXN@28211|Alphaproteobacteria,1FATE@1060|Rhodobacter	28211|Alphaproteobacteria	H	Methionine synthase B12-binding module cap domain protein	mtbC	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
TLS3_k127_7081900_0	1123501.KB902277_gene815	6.847e-137	444.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Radical SAM	MA20_42330	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS3_k127_7101210_2	391593.RCCS2_06099	2.902e-32	127.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2P12R@2433|Roseobacter	28211|Alphaproteobacteria	M	COG0768 Cell division protein FtsI penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
TLS3_k127_7101210_0	1208323.B30_19283	2.826e-146	477.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS3_k127_7101210_1	1417296.U879_05625	1.105e-120	400.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	ghrA	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
TLS3_k127_7104757_2	266809.PM03_00690	9.356e-10	60.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1062 Zn-dependent alcohol dehydrogenases, class III	-	-	1.1.1.306	ko:K00153	-	-	R09129,R10301	RC00069,RC01715	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_7104757_0	391624.OIHEL45_09433	8.486e-183	581.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	dgoD	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
TLS3_k127_7104757_1	1231392.OCGS_1020	1.372e-35	146.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Large extracellular alpha-helical protein	MA20_30110	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
TLS3_k127_7111920_2	1449351.RISW2_12775	1.04e-209	656.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,4KKPV@93682|Roseivivax	28211|Alphaproteobacteria	I	Belongs to the thiolase family	phbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_7111920_3	1266998.ATUJ01000001_gene2655	6.788e-123	399.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,2PU91@265|Paracoccus	28211|Alphaproteobacteria	IQ	KR domain	phbB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
TLS3_k127_7111920_4	1402135.SUH3_15415	2.844e-113	384.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,3ZVQ2@60136|Sulfitobacter	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_7111920_1	1188256.BASI01000002_gene3699	2.483e-315	978.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,3FCI1@34008|Rhodovulum	28211|Alphaproteobacteria	T	Elongation factor G C-terminus	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS3_k127_7111920_7	195105.CN97_00485	1.535e-55	196.0	COG1396@1|root,COG1396@2|Bacteria,1RDBW@1224|Proteobacteria,2U7CY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
TLS3_k127_7111920_5	1123501.KB902279_gene532	5.87e-94	316.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	inositol mono-phosphatase	hisN	-	3.1.3.15,3.1.3.25,3.1.3.93	ko:K01092,ko:K18649	ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00114,M00131	R01185,R01186,R01187,R03013,R07674	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS3_k127_7111920_6	252305.OB2597_02102	1.222e-86	302.0	COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria,2PCJ8@252301|Oceanicola	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	pldB	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
TLS3_k127_7111920_10	89187.ISM_00040	4.041e-35	141.0	COG3255@1|root,COG3255@2|Bacteria,1N0RD@1224|Proteobacteria,2UBXK@28211|Alphaproteobacteria,46QZT@74030|Roseovarius	28211|Alphaproteobacteria	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
TLS3_k127_7111920_9	1123360.thalar_01211	1.381e-45	186.0	COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	MA20_05980	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
TLS3_k127_7111920_0	272943.RSP_2422	0.0	1176.0	COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,1FANR@1060|Rhodobacter	28211|Alphaproteobacteria	L	helicase superfamily c-terminal domain	mgpS	-	3.6.4.13	ko:K17675	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C
TLS3_k127_7111920_11	1449350.OCH239_14570	1.426e-24	108.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2UBS3@28211|Alphaproteobacteria,4KMVD@93682|Roseivivax	28211|Alphaproteobacteria	J	S4 RNA-binding domain	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
TLS3_k127_7111920_8	1317118.ATO8_11194	6.413e-55	193.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,4KMQK@93682|Roseivivax	28211|Alphaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
TLS3_k127_7113932_1	371731.Rsw2DRAFT_0326	5.251e-79	267.0	COG1175@1|root,COG1175@2|Bacteria,1MWXJ@1224|Proteobacteria,2TR77@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type sugar transport systems permease components	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
TLS3_k127_7113932_3	1282362.AEAC466_09565	1.352e-48	180.0	COG0346@1|root,COG0346@2|Bacteria,1RGTU@1224|Proteobacteria,2U9R1@28211|Alphaproteobacteria,2KH4M@204458|Caulobacterales	204458|Caulobacterales	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_7113932_0	371731.Rsw2DRAFT_0325	1.534e-225	708.0	COG1653@1|root,COG1653@2|Bacteria,1PFH6@1224|Proteobacteria,2V8NV@28211|Alphaproteobacteria,1FD0K@1060|Rhodobacter	2|Bacteria	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_7113932_2	376733.IT41_02375	6.522e-66	231.0	COG2103@1|root,COG2103@2|Bacteria,1MVDR@1224|Proteobacteria,2TTCF@28211|Alphaproteobacteria,2PW1A@265|Paracoccus	28211|Alphaproteobacteria	S	SIS domain	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
TLS3_k127_7135003_1	713586.KB900536_gene39	2.117e-118	394.0	COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,1RNIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Trehalose_PPase
TLS3_k127_7135003_0	713586.KB900536_gene40	6.24e-306	961.0	COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,1RPN6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	hydrolase family 65, central catalytic	ycjT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944	2.4.1.64,3.2.1.28,5.4.2.6	ko:K01194,ko:K01838,ko:K04844,ko:K05342	ko00500,ko01100,map00500,map01100	-	R00010,R02727,R02728,R11310	RC00049,RC00408	ko00000,ko00001,ko00537,ko01000	-	GH37,GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
TLS3_k127_7135003_2	935261.JAGL01000027_gene738	2.258e-118	427.0	COG3546@1|root,COG3546@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria,43JY3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	PFAM Manganese containing catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
TLS3_k127_7135003_3	661087.HMPREF1008_01721	1.277e-06	58.0	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,2IK2U@201174|Actinobacteria,4CUF5@84998|Coriobacteriia	84998|Coriobacteriia	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DHH,DHHA1,Helicase_C
TLS3_k127_7147855_1	1048983.EL17_09250	8.179e-77	275.0	COG1228@1|root,COG1228@2|Bacteria,4NGGD@976|Bacteroidetes,47R4K@768503|Cytophagia	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,SnoaL_2
TLS3_k127_7147855_0	1082931.KKY_2611	6.499e-182	574.0	COG1312@1|root,COG1312@2|Bacteria,1MWYD@1224|Proteobacteria,2TTDI@28211|Alphaproteobacteria,3N83N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the dehydration of D-mannonate	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
TLS3_k127_7149409_5	1105367.CG50_09945	6.167e-27	110.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Cold shock	cspA4	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS3_k127_7149409_2	1417296.U879_12885	1.025e-114	382.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_7149409_3	1317124.DW2_01485	9.47e-43	165.0	COG1309@1|root,COG1309@2|Bacteria,1MZ9E@1224|Proteobacteria,2U0MU@28211|Alphaproteobacteria,2XKIY@285107|Thioclava	28211|Alphaproteobacteria	K	AefR-like transcriptional repressor, C-terminal region	acnR	-	-	-	-	-	-	-	-	-	-	-	TetR_C_7,TetR_N
TLS3_k127_7149409_1	1417296.U879_18080	3.019e-128	417.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2U06F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_7149409_4	314264.ROS217_20872	4.707e-35	135.0	COG5470@1|root,COG5470@2|Bacteria,1RGYN@1224|Proteobacteria,2U9AN@28211|Alphaproteobacteria,46R06@74030|Roseovarius	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
TLS3_k127_7149409_6	766499.C357_22360	1.326e-24	106.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2UBQW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	MA20_24570	-	-	-	-	-	-	-	-	-	-	-	DUF1330
TLS3_k127_7149409_0	272943.RSP_0451	0.0	1277.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,1FB15@1060|Rhodobacter	28211|Alphaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS3_k127_7187807_1	631454.N177_2171	2.023e-99	328.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,1JPXN@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	SAF	MA20_06800	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
TLS3_k127_7187807_2	153948.NAL212_0730	2.892e-85	292.0	28KEA@1|root,2ZA0J@2|Bacteria,1R5TS@1224|Proteobacteria,2WBU3@28216|Betaproteobacteria,373TA@32003|Nitrosomonadales	28216|Betaproteobacteria	H	PFAM Sulfotransferase	-	-	2.8.2.1	ko:K01014	ko05204,map05204	-	R01242	RC00007,RC00128	ko00000,ko00001,ko01000	-	-	-	Sulfotransfer_1
TLS3_k127_7187807_5	1185652.USDA257_c43110	1.898e-14	78.0	COG3278@1|root,COG3278@2|Bacteria,1NMI5@1224|Proteobacteria,2TVT7@28211|Alphaproteobacteria,4BNP6@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7187807_0	1122180.Lokhon_02267	1.242e-142	461.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,2P7WX@245186|Loktanella	28211|Alphaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS3_k127_7187807_3	1417296.U879_09760	3.112e-80	293.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	MA20_44650	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS3_k127_7187807_4	1121271.AUCM01000005_gene824	1.636e-65	230.0	28H8H@1|root,2Z7KE@2|Bacteria,1MV77@1224|Proteobacteria,2TSVV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	N-terminal double-transmembrane domain	MA20_44655	-	-	-	-	-	-	-	-	-	-	-	BatA,DUF4159
TLS3_k127_7190987_3	1120792.JAFV01000001_gene1775	9.893e-06	50.0	COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria,36Y0W@31993|Methylocystaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
TLS3_k127_7190987_1	1089551.KE386572_gene4483	3.847e-228	728.0	COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,2TT2M@28211|Alphaproteobacteria,4BRCH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS3_k127_7190987_2	1089551.KE386572_gene4482	6.917e-117	412.0	COG0510@1|root,COG0510@2|Bacteria,1MVBB@1224|Proteobacteria,2TT5Z@28211|Alphaproteobacteria,4BRU5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Choline_kinase
TLS3_k127_7190987_0	1267005.KB911264_gene3112	4.675e-251	798.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	Sardh	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.3.19	ko:K19191	ko00760,ko01120,map00760,map01120	-	R10102	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
TLS3_k127_7216068_5	411684.HPDFL43_14997	3.703e-14	85.0	COG2771@1|root,COG2771@2|Bacteria,1N6UR@1224|Proteobacteria,2U10Z@28211|Alphaproteobacteria,43K9B@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Autoinducer binding domain	-	-	-	ko:K18098	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
TLS3_k127_7216068_0	1123501.KB902277_gene840	5.176e-99	338.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
TLS3_k127_7216068_2	1121271.AUCM01000008_gene3126	2.895e-54	192.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
TLS3_k127_7216068_1	571166.KI421509_gene1322	1.505e-54	195.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria,2U74A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	-	-	-	-	-	-	-	-	-	-	-	NifU_N
TLS3_k127_7216068_3	1525715.IX54_10945	3.38e-43	167.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria,2PWWF@265|Paracoccus	28211|Alphaproteobacteria	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
TLS3_k127_7216068_4	999611.KI421504_gene2720	4.704e-31	123.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2UGK6@28211|Alphaproteobacteria,281DV@191028|Leisingera	28211|Alphaproteobacteria	I	Phosphatidylglycerophosphatase A	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
TLS3_k127_7226592_0	414684.RC1_0066	3.935e-77	265.0	COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,2TRW8@28211|Alphaproteobacteria,2JS45@204441|Rhodospirillales	204441|Rhodospirillales	S	Phage terminase large subunit (GpA)	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_GpA
TLS3_k127_7226592_3	1232443.BAIA02000135_gene1431	3.156e-15	83.0	COG4220@1|root,COG4220@2|Bacteria,1VGX7@1239|Firmicutes,24S8B@186801|Clostridia	186801|Clostridia	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7226592_2	1430440.MGMSRv2_0684	3.338e-33	133.0	29U1D@1|root,30FAK@2|Bacteria,1RCY2@1224|Proteobacteria,2UF0W@28211|Alphaproteobacteria,2JX40@204441|Rhodospirillales	204441|Rhodospirillales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7226592_1	1123501.KB902299_gene3836	2.195e-35	139.0	COG1846@1|root,COG1846@2|Bacteria,1QV27@1224|Proteobacteria,2TWVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Protein of unknown function (DUF3489)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3489
TLS3_k127_7235604_5	877424.ATWC01000007_gene195	1.878e-07	61.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,27JZW@186928|unclassified Lachnospiraceae	186801|Clostridia	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,sCache_3_3
TLS3_k127_7235604_0	314264.ROS217_17025	9.291e-183	579.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,46QF3@74030|Roseovarius	28211|Alphaproteobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739,ko:K10764	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_7235604_3	1188256.BASI01000005_gene2053	2.916e-130	434.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2TUES@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
TLS3_k127_7235604_2	314256.OG2516_07435	2.607e-145	475.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,2PCTQ@252301|Oceanicola	28211|Alphaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS3_k127_7235604_1	314256.OG2516_07435	2.634e-174	561.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,2PCTQ@252301|Oceanicola	28211|Alphaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS3_k127_7235604_6	760568.Desku_2077	1.624e-06	61.0	COG0500@1|root,COG2226@2|Bacteria,1UY28@1239|Firmicutes,24GXH@186801|Clostridia,262Q6@186807|Peptococcaceae	186801|Clostridia	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_7235604_4	1208323.B30_04892	2.019e-123	397.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
TLS3_k127_7252964_1	1040989.AWZU01000002_gene5205	3.636e-93	309.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2TSZ0@28211|Alphaproteobacteria,3K3A5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.32	ko:K18456	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_1
TLS3_k127_7252964_0	1082933.MEA186_14177	6.147e-126	420.0	COG3257@1|root,COG3257@2|Bacteria,1MW60@1224|Proteobacteria,2TS34@28211|Alphaproteobacteria,43HMF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein possibly involved in glyoxylate utilization	-	-	3.5.3.26	ko:K14977	ko00230,ko01120,map00230,map01120	-	R05554	RC01419	ko00000,ko00001,ko01000	-	-	-	Cupin_2
TLS3_k127_7252964_2	1500301.JQMF01000028_gene2817	4.053e-49	193.0	COG3194@1|root,COG3194@2|Bacteria,1RH5G@1224|Proteobacteria,2U8A4@28211|Alphaproteobacteria,4BCRU@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source	allA	-	4.3.2.3	ko:K01483	ko00230,ko01100,map00230,map01100	-	R00776	RC00153,RC00379	ko00000,ko00001,ko01000	-	-	-	Ureidogly_lyase
TLS3_k127_7268361_3	1211115.ALIQ01000016_gene4589	9.726e-71	240.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,3N9QG@45404|Beijerinckiaceae	28211|Alphaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS3_k127_7268361_2	216596.RL1142	8.72e-133	444.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BA4K@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_19,TPR_8,Trans_reg_C
TLS3_k127_7268361_1	1446473.JHWH01000002_gene1653	2.851e-165	524.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,2PUF5@265|Paracoccus	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	gyaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_7268361_4	1231392.OCGS_1657	9.481e-52	190.0	COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	SH3_4
TLS3_k127_7268361_0	1123257.AUFV01000019_gene2038	8.812e-308	960.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS3_k127_7287362_15	66869.JNXG01000002_gene5923	1.504e-12	68.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,41ATK@629295|Streptomyces griseus group	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS3_k127_7287362_12	675635.Psed_3776	2.308e-28	119.0	COG4319@1|root,COG4319@2|Bacteria,2II1S@201174|Actinobacteria,4E56Z@85010|Pseudonocardiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,SnoaL_3
TLS3_k127_7287362_11	1121861.KB899922_gene3157	6.505e-54	194.0	COG2764@1|root,COG2764@2|Bacteria,1RJPS@1224|Proteobacteria,2UACG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_7287362_9	794846.AJQU01000026_gene661	4.992e-103	347.0	COG4312@1|root,COG4312@2|Bacteria,1QIBA@1224|Proteobacteria,2TTFP@28211|Alphaproteobacteria,4B7GU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
TLS3_k127_7287362_13	452652.KSE_64370	2.168e-21	105.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,2M36W@2063|Kitasatospora	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
TLS3_k127_7287362_3	1057002.KB905370_gene4497	8.438e-139	447.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TVPU@28211|Alphaproteobacteria,4BD7I@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	lactate/malate dehydrogenase, NAD binding domain	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
TLS3_k127_7287362_10	1461694.ATO9_11520	1.039e-82	303.0	COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2TQXV@28211|Alphaproteobacteria,2PCNP@252301|Oceanicola	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	gltR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_7287362_0	1547437.LL06_22105	8.065e-283	873.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,43IP5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_7287362_2	1547437.LL06_22110	2.083e-171	544.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,43H1W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_27425	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_7287362_8	391624.OIHEL45_14564	9.761e-108	370.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	-	-	1.1.1.31,4.2.1.17	ko:K00020,ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05066,R05595,R06411,R06412,R06942,R08093	RC00099,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
TLS3_k127_7287362_5	571166.KI421509_gene1694	2.959e-117	389.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS3_k127_7287362_6	376733.IT41_19445	2.18e-114	383.0	COG0607@1|root,COG4275@1|root,COG0607@2|Bacteria,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TRC3@28211|Alphaproteobacteria,2PV8V@265|Paracoccus	28211|Alphaproteobacteria	P	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,Rhodanese
TLS3_k127_7287362_4	472175.EL18_00610	1.508e-124	409.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria,43HAC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_7287362_7	1415756.JQMY01000001_gene2594	2.499e-114	380.0	COG0583@1|root,COG0583@2|Bacteria,1MXC9@1224|Proteobacteria,2TTTY@28211|Alphaproteobacteria,2PCYR@252301|Oceanicola	28211|Alphaproteobacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7287362_14	349102.Rsph17025_1534	2.766e-21	96.0	2CHPT@1|root,32YYG@2|Bacteria,1N6R5@1224|Proteobacteria,2UFC7@28211|Alphaproteobacteria,1FC4R@1060|Rhodobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7287362_1	1247963.JPHU01000012_gene874	4.766e-175	561.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
TLS3_k127_7287362_16	394221.Mmar10_1019	5.471e-11	70.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria,43XN9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
TLS3_k127_7308318_7	290397.Adeh_2255	1.196e-32	130.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,437TD@68525|delta/epsilon subdivisions,2WT6I@28221|Deltaproteobacteria,2YX1E@29|Myxococcales	28221|Deltaproteobacteria	C	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS3_k127_7308318_2	1238182.C882_0314	5.63e-104	356.0	COG0644@1|root,COG0644@2|Bacteria,1R26V@1224|Proteobacteria,2TZC1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
TLS3_k127_7308318_5	981384.AEYW01000004_gene1795	5.115e-45	179.0	COG0596@1|root,COG0596@2|Bacteria,1NCX0@1224|Proteobacteria,2UEMT@28211|Alphaproteobacteria,4NBVB@97050|Ruegeria	28211|Alphaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_7308318_6	981384.AEYW01000004_gene1793	4.681e-44	166.0	COG2346@1|root,COG2346@2|Bacteria,1Q6XQ@1224|Proteobacteria,2U9CB@28211|Alphaproteobacteria,4NCTS@97050|Ruegeria	28211|Alphaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS3_k127_7308318_1	501479.ACNW01000058_gene4412	7.148e-137	444.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
TLS3_k127_7308318_0	501479.ACNW01000058_gene4413	7.99e-191	621.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U17W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9,Response_reg
TLS3_k127_7308318_3	501479.ACNW01000058_gene4414	1.659e-96	326.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Guanylate_cyc,Response_reg,Trans_reg_C
TLS3_k127_7308318_4	1211115.ALIQ01000190_gene914	1.247e-72	261.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TWTV@28211|Alphaproteobacteria,3NBUK@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_7308318_8	1040986.ATYO01000009_gene2304	1.012e-16	80.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2U5CQ@28211|Alphaproteobacteria,43R8U@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
TLS3_k127_7324585_1	314270.RB2083_2019	7.231e-234	767.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria,3ZG8P@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	L	Superfamily II DNA	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
TLS3_k127_7324585_9	412597.AEPN01000022_gene823	3.76e-62	219.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,2PUXY@265|Paracoccus	28211|Alphaproteobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TLS3_k127_7324585_2	1353537.TP2_16285	1.227e-135	475.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,2XPJK@285107|Thioclava	28211|Alphaproteobacteria	S	Reductase C-terminal	thcD	-	1.14.13.111,1.18.1.3	ko:K00529,ko:K16968	ko00071,ko00360,ko00920,ko01120,ko01220,map00071,map00360,map00920,map01120,map01220	M00545	R02000,R06782,R06783,R09513	RC00098,RC02556	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
TLS3_k127_7324585_12	1121271.AUCM01000002_gene3971	2.168e-29	127.0	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2UBWN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS3_k127_7324585_8	1502851.FG93_02072	4.708e-83	291.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,3JT29@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	gst1	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS3_k127_7324585_15	391595.RLO149_c000780	5.918e-14	86.0	2AJGT@1|root,31A38@2|Bacteria,1Q4UE@1224|Proteobacteria,2VB99@28211|Alphaproteobacteria,2P4BY@2433|Roseobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7324585_10	1123501.KB902280_gene513	3.779e-38	147.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS3_k127_7324585_0	1417296.U879_06735	0.0	1133.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
TLS3_k127_7324585_14	1280380.KR100_02190	1.78e-16	89.0	2DG8R@1|root,2ZUYV@2|Bacteria,1G8JI@1117|Cyanobacteria,1H2G4@1129|Synechococcus	1117|Cyanobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
TLS3_k127_7324585_11	1002340.AFCF01000016_gene2559	3.446e-32	138.0	2DKXV@1|root,30THP@2|Bacteria,1PQI1@1224|Proteobacteria,2UFVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
TLS3_k127_7324585_7	1449351.RISW2_16510	4.071e-94	331.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2U2Y6@28211|Alphaproteobacteria,4KM0W@93682|Roseivivax	28211|Alphaproteobacteria	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_7324585_4	1188256.BASI01000001_gene514	1.029e-108	358.0	COG1215@1|root,COG1215@2|Bacteria,1R6YR@1224|Proteobacteria,2V85Y@28211|Alphaproteobacteria,3FDP4@34008|Rhodovulum	28211|Alphaproteobacteria	M	N-terminal domain of galactosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
TLS3_k127_7324585_5	371731.Rsw2DRAFT_0478	4.876e-107	356.0	COG0463@1|root,COG0463@2|Bacteria,1MXQB@1224|Proteobacteria,2U2SY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyltransferase family 92	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_4,Glyco_transf_92
TLS3_k127_7324585_3	195105.CN97_11345	3.436e-128	415.0	COG0695@1|root,COG0695@2|Bacteria,1MXQW@1224|Proteobacteria,2TT7R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0695 glutaredoxin and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin,MauE
TLS3_k127_7324585_6	648885.KB316283_gene3532	5.329e-102	340.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,1JSC1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	GK	PFAM ROK family	mak	-	2.7.1.2,2.7.1.4	ko:K00845,ko:K00847	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS3_k127_7324585_13	1381123.AYOD01000049_gene35	1.156e-20	98.0	COG0239@1|root,COG0239@2|Bacteria,1N3EB@1224|Proteobacteria,2VAM9@28211|Alphaproteobacteria,43M4M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	D	CrcB-like protein, Camphor Resistance (CrcB)	-	-	-	-	-	-	-	-	-	-	-	-	CRCB
TLS3_k127_7324585_16	1331060.RLDS_11610	1.872e-09	62.0	COG0239@1|root,COG0239@2|Bacteria	2|Bacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS3_k127_7327311_2	1188256.BASI01000003_gene2531	7.309e-95	331.0	COG0303@1|root,COG0303@2|Bacteria,1QUKM@1224|Proteobacteria,2TWCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
TLS3_k127_7327311_1	1188256.BASI01000003_gene2530	4.407e-130	429.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,3FE6J@34008|Rhodovulum	28211|Alphaproteobacteria	O	XdhC Rossmann domain	MA20_09415	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS3_k127_7327311_0	398580.Dshi_1476	1.016e-283	881.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS3_k127_7339650_0	1469613.JT55_14395	1.538e-141	456.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,3FCS1@34008|Rhodovulum	28211|Alphaproteobacteria	CH	FAD binding domain	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
TLS3_k127_7339650_2	375451.RD1_1845	4.399e-05	53.0	COG1961@1|root,COG1961@2|Bacteria,1PF4F@1224|Proteobacteria,2V7FP@28211|Alphaproteobacteria,2P3YH@2433|Roseobacter	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7339650_1	2340.JV46_10900	6.084e-69	246.0	COG1442@1|root,COG1442@2|Bacteria,1PS3F@1224|Proteobacteria,1SSS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_734384_4	1354722.JQLS01000008_gene1909	5.464e-42	159.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria,46QTS@74030|Roseovarius	28211|Alphaproteobacteria	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS3_k127_734384_2	314265.R2601_23243	2.097e-76	260.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2U74H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS3_k127_734384_1	794846.AJQU01000059_gene427	3.081e-164	527.0	COG2899@1|root,COG2899@2|Bacteria,1NURT@1224|Proteobacteria,2TRRF@28211|Alphaproteobacteria,4B7JU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
TLS3_k127_734384_3	1280949.HAD_04065	1.22e-55	214.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TXUV@28211|Alphaproteobacteria,440U5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
TLS3_k127_734384_5	287.DR97_278	3.302e-21	98.0	COG0642@1|root,COG0745@1|root,COG2770@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YE0H@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg
TLS3_k127_734384_6	983917.RGE_44730	2.655e-05	53.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VR5U@28216|Betaproteobacteria,1KKW9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cysteine-rich motif following a subset of SET domains	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
TLS3_k127_734384_0	1123229.AUBC01000004_gene3283	2.928e-255	808.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JR86@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K21134	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27	-	-	ACR_tran
TLS3_k127_7346911_0	935565.JAEM01000031_gene2623	9.668e-280	870.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,2PWCA@265|Paracoccus	28211|Alphaproteobacteria	I	Carboxyl transferase domain	mccB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_7346911_7	1569209.BBPH01000075_gene825	7.303e-28	117.0	2ETYH@1|root,33MFM@2|Bacteria,1R35V@1224|Proteobacteria,2TZY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
TLS3_k127_7346911_8	1545915.JROG01000004_gene2353	1.676e-20	97.0	COG4374@1|root,COG4374@2|Bacteria,1N7EF@1224|Proteobacteria,2UFJV@28211|Alphaproteobacteria,2K75Y@204457|Sphingomonadales	204457|Sphingomonadales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
TLS3_k127_7346911_2	391613.RTM1035_08709	1.252e-194	612.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,46Q1M@74030|Roseovarius	28211|Alphaproteobacteria	C	COG1960 Acyl-CoA dehydrogenases	ivd	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_7346911_6	1280944.HY17_00750	1.483e-42	162.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,2U723@28211|Alphaproteobacteria,43XTE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	COG3040 Bacterial lipocalin	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
TLS3_k127_7346911_4	1123501.KB902315_gene3310	2.65e-88	297.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.9,3.1.3.15,4.2.1.19	ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03013,R03243,R03457	RC00006,RC00017,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	IGPD
TLS3_k127_7346911_3	398580.Dshi_0795	4.258e-91	314.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
TLS3_k127_7346911_1	371731.Rsw2DRAFT_2839	1.372e-206	653.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
TLS3_k127_7346911_5	1121271.AUCM01000003_gene1783	1.834e-63	225.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U5BD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS3_k127_7346911_9	1317124.DW2_03369	4.883e-19	86.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,2XMHR@285107|Thioclava	28211|Alphaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03768,ko:K09565	ko04020,ko04022,ko05012,ko05016,ko05145,map04020,map04022,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Pro_isomerase
TLS3_k127_7349254_3	1449351.RISW2_23135	5.28e-24	103.0	COG5349@1|root,COG5349@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF983)	MA20_36345	-	-	-	-	-	-	-	-	-	-	-	DUF983
TLS3_k127_7349254_0	1353537.TP2_04180	4.336e-60	229.0	COG3409@1|root,COG4249@1|root,COG3409@2|Bacteria,COG4249@2|Bacteria,1PRS3@1224|Proteobacteria,2V40E@28211|Alphaproteobacteria,2XN4S@285107|Thioclava	28211|Alphaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS3_k127_7349254_1	1121015.N789_13440	1.349e-41	166.0	COG0346@1|root,COG0346@2|Bacteria,1N3K0@1224|Proteobacteria,1SBM8@1236|Gammaproteobacteria,1X6WJ@135614|Xanthomonadales	135614|Xanthomonadales	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7349254_4	331869.BAL199_07533	8.66e-13	79.0	COG2931@1|root,COG2931@2|Bacteria,1RCTH@1224|Proteobacteria,2U58A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_7349254_2	1417296.U879_11115	5.312e-32	130.0	COG0454@1|root,COG0456@2|Bacteria,1RCBE@1224|Proteobacteria,2U1JB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	yobR	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_7375648_4	376733.IT41_11710	5.4e-33	133.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,2PW32@265|Paracoccus	28211|Alphaproteobacteria	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
TLS3_k127_7375648_0	398580.Dshi_1851	0.0	1500.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS3_k127_7375648_3	1123501.KB902310_gene177	5.418e-46	169.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS3_k127_7375648_1	1123501.KB902277_gene1060	1.137e-63	226.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Secreted protein	MA20_43790	-	-	-	-	-	-	-	-	-	-	-	DUF1223
TLS3_k127_7375648_2	314232.SKA53_08761	7.241e-59	212.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2TS2H@28211|Alphaproteobacteria,2P8CU@245186|Loktanella	28211|Alphaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	msbB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
TLS3_k127_739323_2	1547437.LL06_07640	2.438e-44	163.0	COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2TSUM@28211|Alphaproteobacteria,43I6K@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS3_k127_739323_0	1298858.AUEL01000004_gene925	2.017e-74	252.0	COG4154@1|root,COG4154@2|Bacteria,1RJ03@1224|Proteobacteria,2U9P9@28211|Alphaproteobacteria,43K1W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the RbsD FucU family	-	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
TLS3_k127_739323_1	371731.Rsw2DRAFT_0062	4.997e-67	236.0	COG2755@1|root,COG2755@2|Bacteria,1REJS@1224|Proteobacteria,2U7DH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG2755 Lysophospholipase L1 and related	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS3_k127_7394305_4	272942.RCAP_rcc03487	3.546e-30	139.0	COG3118@1|root,COG3118@2|Bacteria,1R8CU@1224|Proteobacteria,2U2AN@28211|Alphaproteobacteria,1FBR5@1060|Rhodobacter	28211|Alphaproteobacteria	O	belongs to the thioredoxin family	flaA	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7394305_0	292414.TM1040_2951	1.09e-142	458.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,4NBU8@97050|Ruegeria	28211|Alphaproteobacteria	N	MotA/TolQ/ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
TLS3_k127_7394305_3	1028801.RG1141_CH07880	2.545e-39	156.0	COG4332@1|root,COG4332@2|Bacteria,1N0V1@1224|Proteobacteria,2UB78@28211|Alphaproteobacteria,4BEBJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1062
TLS3_k127_7394305_5	349102.Rsph17025_2748	2.855e-26	115.0	COG3334@1|root,COG3334@2|Bacteria,1RKF6@1224|Proteobacteria,2UC98@28211|Alphaproteobacteria,1FC21@1060|Rhodobacter	28211|Alphaproteobacteria	S	PFAM MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	MgtE_N
TLS3_k127_7394305_6	371731.Rsw2DRAFT_0380	2.611e-10	69.0	2CM6A@1|root,32SDT@2|Bacteria,1N0P3@1224|Proteobacteria,2UCD1@28211|Alphaproteobacteria,1FBZT@1060|Rhodobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7394305_2	1469613.JT55_00380	1.723e-41	162.0	COG1580@1|root,COG1580@2|Bacteria,1RH5D@1224|Proteobacteria,2U9BF@28211|Alphaproteobacteria,3FE9F@34008|Rhodovulum	28211|Alphaproteobacteria	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
TLS3_k127_7394305_1	1231392.OCGS_2094	6.376e-134	446.0	COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2TR6J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
TLS3_k127_7396345_4	272943.RSP_0394	2.828e-84	282.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria,1FBIW@1060|Rhodobacter	28211|Alphaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS3_k127_7396345_0	1449351.RISW2_14315	1.571e-124	408.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,4KMD1@93682|Roseivivax	28211|Alphaproteobacteria	F	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS3_k127_7396345_1	1469613.JT55_08505	1.539e-119	399.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2TS5Q@28211|Alphaproteobacteria,3FD8F@34008|Rhodovulum	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
TLS3_k127_7396345_3	1101189.AQUO01000001_gene3531	1.564e-84	294.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,2PU1T@265|Paracoccus	28211|Alphaproteobacteria	H	Lumazine binding domain	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
TLS3_k127_7396345_2	716928.AJQT01000114_gene3031	5.119e-112	380.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria,4BHPK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_7396345_5	716928.AJQT01000114_gene3032	1.93e-76	265.0	COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,2TR7M@28211|Alphaproteobacteria,4BICQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
TLS3_k127_7396345_6	716928.AJQT01000114_gene3033	2.543e-26	119.0	COG0607@1|root,COG0607@2|Bacteria,1N61C@1224|Proteobacteria,2UDHA@28211|Alphaproteobacteria,4BJM5@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_741529_3	1429916.X566_16830	4.392e-69	249.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TQPQ@28211|Alphaproteobacteria,3JRXB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	hprA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_741529_0	1122132.AQYH01000004_gene1606	9.899e-151	505.0	COG0148@1|root,COG0148@2|Bacteria,1PIEJ@1224|Proteobacteria,2TT8V@28211|Alphaproteobacteria,4BD27@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	-	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS3_k127_741529_1	331869.BAL199_22132	1.949e-113	389.0	COG4857@1|root,COG4857@2|Bacteria,1MXBW@1224|Proteobacteria,2TR0Z@28211|Alphaproteobacteria,4BRV5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_741529_2	266265.Bxe_C0625	3.573e-86	306.0	COG0179@1|root,COG0179@2|Bacteria,1QUQP@1224|Proteobacteria,2VQEI@28216|Betaproteobacteria,1K3B3@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS3_k127_741529_4	1120950.KB892757_gene6423	3.896e-23	110.0	2DBNR@1|root,2ZA54@2|Bacteria	2|Bacteria	S	Methane oxygenase PmoA	-	-	-	-	-	-	-	-	-	-	-	-	PmoA
TLS3_k127_7424217_0	1188256.BASI01000001_gene422	0.0	1058.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,3FCG6@34008|Rhodovulum	28211|Alphaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS3_k127_7424217_1	1123501.KB902300_gene3912	8.229e-12	68.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,2TQRM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	vdlC	GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_7427715_0	521098.Aaci_0638	2.354e-27	122.0	COG4424@1|root,COG4424@2|Bacteria,1V5ZE@1239|Firmicutes,4HY3Z@91061|Bacilli	91061|Bacilli	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
TLS3_k127_7427715_1	648885.KB316282_gene852	5.742e-14	81.0	COG4636@1|root,COG4636@2|Bacteria,1RHNE@1224|Proteobacteria,2U9GQ@28211|Alphaproteobacteria,1JSJS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
TLS3_k127_7428148_2	1337093.MBE-LCI_0766	3.461e-36	139.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,2P7XI@245186|Loktanella	28211|Alphaproteobacteria	H	tRNA (Uracil-5-)-methyltransferase	rumA	-	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	tRNA_U5-meth_tr
TLS3_k127_7428148_3	1449350.OCH239_09395	4.05e-29	124.0	COG0847@1|root,COG0847@2|Bacteria,1RHD8@1224|Proteobacteria,2UFQU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
TLS3_k127_7428148_0	1188256.BASI01000001_gene990	7.282e-172	554.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2TQY2@28211|Alphaproteobacteria,3FCJQ@34008|Rhodovulum	28211|Alphaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
TLS3_k127_7428148_1	1188256.BASI01000001_gene989	1.608e-104	347.0	COG4143@1|root,COG4143@2|Bacteria,1MUBB@1224|Proteobacteria,2TTS4@28211|Alphaproteobacteria,3FDYN@34008|Rhodovulum	28211|Alphaproteobacteria	H	Bacterial extracellular solute-binding protein	tbpA	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_1,SBP_bac_11,SBP_bac_6,SBP_bac_8
TLS3_k127_7435687_11	266809.PM03_13595	6.018e-56	200.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	MA20_24805	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
TLS3_k127_7435687_0	195105.CN97_19970	1.859e-242	754.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS3_k127_7435687_4	1415756.JQMY01000001_gene502	9.539e-121	401.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,2PD7C@252301|Oceanicola	28211|Alphaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
TLS3_k127_7435687_1	1317124.DW2_09336	1.721e-228	732.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,2XKW3@285107|Thioclava	28211|Alphaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
TLS3_k127_7435687_10	1105367.CG50_12105	5.007e-56	211.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2U9T9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
TLS3_k127_7435687_7	89187.ISM_06720	2.066e-90	304.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,46PM6@74030|Roseovarius	28211|Alphaproteobacteria	D	COG1192 ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS3_k127_7435687_6	349102.Rsph17025_2663	1.357e-106	357.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,1FAU0@1060|Rhodobacter	28211|Alphaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
TLS3_k127_7435687_3	1525715.IX54_03605	8.12e-148	482.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,2PVA6@265|Paracoccus	28211|Alphaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
TLS3_k127_7435687_8	314232.SKA53_11848	1.212e-69	258.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,2P8QH@245186|Loktanella	28211|Alphaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS3_k127_7435687_5	314271.RB2654_13554	7.566e-107	351.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
TLS3_k127_7435687_2	1417296.U879_11460	5.916e-153	501.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
TLS3_k127_7435687_9	314270.RB2083_751	1.753e-58	209.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,3ZH71@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS3_k127_7435687_13	1479237.JMLY01000001_gene2086	1.235e-38	153.0	COG5549@1|root,COG5549@2|Bacteria,1RIJW@1224|Proteobacteria,1SIG8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
TLS3_k127_7435687_12	266809.PM03_08995	5.067e-48	173.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS3_k127_7443_1	1461693.ATO10_00845	7.171e-91	307.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS3_k127_7443_0	1336245.JAGO01000011_gene536	8.258e-119	392.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RN5Z@1236|Gammaproteobacteria,1XI47@135619|Oceanospirillales	135619|Oceanospirillales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_7443_4	1469613.JT55_15765	5.76e-18	98.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2TRIV@28211|Alphaproteobacteria,3FDC6@34008|Rhodovulum	28211|Alphaproteobacteria	N	FliG middle domain	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
TLS3_k127_7443_2	644107.SL1157_1264	1.973e-87	297.0	COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2TT93@28211|Alphaproteobacteria,4NAFS@97050|Ruegeria	28211|Alphaproteobacteria	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
TLS3_k127_7443_3	1231392.OCGS_2092	4.827e-25	108.0	COG1886@1|root,COG1886@2|Bacteria,1MZKP@1224|Proteobacteria	1224|Proteobacteria	N	COG1886 Flagellar motor switch type III secretory pathway protein	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
TLS3_k127_745491_11	477228.YO5_17155	1.383e-98	340.0	COG2303@1|root,COG2303@2|Bacteria,1MXUT@1224|Proteobacteria,1S03P@1236|Gammaproteobacteria,1Z409@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,FAD_binding_3,GMC_oxred_C,Pyr_redox_2
TLS3_k127_745491_0	472175.EL18_01940	1.878e-266	831.0	COG3507@1|root,COG3507@2|Bacteria,1NNX4@1224|Proteobacteria,2U06C@28211|Alphaproteobacteria,43J8T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 43	xynA	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
TLS3_k127_745491_5	314256.OG2516_13901	4.38e-159	512.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TSKV@28211|Alphaproteobacteria,2PCEA@252301|Oceanicola	28211|Alphaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_745491_4	1156935.QWE_11062	1.65e-172	563.0	COG0673@1|root,COG0673@2|Bacteria,1MVT5@1224|Proteobacteria,2TV1T@28211|Alphaproteobacteria,4B8B1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS3_k127_745491_10	366394.Smed_1723	1.996e-101	340.0	COG1082@1|root,COG1082@2|Bacteria,1RAC3@1224|Proteobacteria,2U59H@28211|Alphaproteobacteria,4BB2F@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Sugar phosphate isomerases epimerases	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS3_k127_745491_8	1410620.SHLA_55c000470	1.382e-155	497.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4B80Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS3_k127_745491_3	411684.HPDFL43_19337	3.961e-173	546.0	COG0395@1|root,COG0395@2|Bacteria,1MUT9@1224|Proteobacteria,2TRQ0@28211|Alphaproteobacteria,43J9S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K17317	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
TLS3_k127_745491_6	1547437.LL06_06850	1.771e-158	516.0	COG1175@1|root,COG1175@2|Bacteria,1MU84@1224|Proteobacteria,2TRM5@28211|Alphaproteobacteria,43GYF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	inner membrane component	-	-	-	ko:K17316	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
TLS3_k127_745491_2	716928.AJQT01000001_gene230	4.513e-196	620.0	COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,2TUCZ@28211|Alphaproteobacteria,4B8A0@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_745491_9	1449065.JMLL01000012_gene3589	1.453e-117	387.0	COG1609@1|root,COG1609@2|Bacteria,1QVB7@1224|Proteobacteria,2U51T@28211|Alphaproteobacteria,43IUT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
TLS3_k127_745491_1	1547437.LL06_21245	1.476e-231	758.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,43IYY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	dehydratase	garD	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0071704,GO:1901575	4.2.1.42,4.2.1.7	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00631	R01540,R05608	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
TLS3_k127_745491_7	314264.ROS217_10977	1.5e-156	503.0	COG1744@1|root,COG1744@2|Bacteria,1MVU5@1224|Proteobacteria,2TTTH@28211|Alphaproteobacteria,46NR0@74030|Roseovarius	28211|Alphaproteobacteria	S	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
TLS3_k127_745491_12	349102.Rsph17025_0952	1.759e-98	326.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,1FB4B@1060|Rhodobacter	28211|Alphaproteobacteria	S	PFAM ABC transporter	rbsA4	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_7472777_2	1423144.Gal_03669	1.882e-20	102.0	COG5375@1|root,COG5375@2|Bacteria,1RJ23@1224|Proteobacteria,2UAJS@28211|Alphaproteobacteria,34E5H@302485|Phaeobacter	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
TLS3_k127_7472777_0	314256.OG2516_11001	1.277e-123	406.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria,2PCNN@252301|Oceanicola	28211|Alphaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
TLS3_k127_7472777_1	1123501.KB902314_gene3114	3.797e-93	311.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	3-5 exonuclease	rnd1	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
TLS3_k127_7475748_1	935848.JAEN01000030_gene264	1.185e-141	454.0	COG0329@1|root,COG0329@2|Bacteria,1MV7E@1224|Proteobacteria,2TTT5@28211|Alphaproteobacteria,2PUI6@265|Paracoccus	28211|Alphaproteobacteria	EM	Protein of unknown function (DUF993)	MA20_16880	-	-	-	-	-	-	-	-	-	-	-	DUF993
TLS3_k127_7475748_2	412597.AEPN01000054_gene3705	1.021e-121	398.0	COG1082@1|root,COG1082@2|Bacteria,1Q173@1224|Proteobacteria,2TTFM@28211|Alphaproteobacteria,2PV1Q@265|Paracoccus	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	MA20_16875	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS3_k127_7475748_0	536019.Mesop_5990	7.484e-213	668.0	COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
TLS3_k127_7475748_3	501479.ACNW01000082_gene4727	7.858e-21	91.0	COG0251@1|root,COG0251@2|Bacteria,1RAKQ@1224|Proteobacteria,2U5F4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS3_k127_749766_4	460265.Mnod_4826	5.846e-29	121.0	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2U8VZ@28211|Alphaproteobacteria,1JTEM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	DUF3734,Patatin
TLS3_k127_749766_2	1231392.OCGS_1024	4.988e-38	144.0	COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	integral membrane protein	MA20_25225	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TLS3_k127_749766_0	467661.RKLH11_951	1.195e-228	714.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,3ZG0P@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
TLS3_k127_749766_1	1367847.JCM7686_3432	5.761e-55	207.0	COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria,2PVF4@265|Paracoccus	28211|Alphaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
TLS3_k127_749766_3	1121271.AUCM01000009_gene2182	8.199e-37	141.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TTE1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
TLS3_k127_7498457_2	1469613.JT55_02035	1.163e-83	281.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,3FDZB@34008|Rhodovulum	28211|Alphaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS3_k127_7498457_1	351016.RAZWK3B_06857	2.799e-97	334.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,2P27R@2433|Roseobacter	28211|Alphaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS3_k127_7498457_0	1353537.TP2_03705	5.465e-112	375.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2XN02@285107|Thioclava	28211|Alphaproteobacteria	S	Putative modulator of DNA gyrase	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
TLS3_k127_7521636_2	1380350.JIAP01000002_gene4349	2.007e-123	401.0	COG1175@1|root,COG1175@2|Bacteria,1R6AD@1224|Proteobacteria,2TTUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	transporter	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_7521636_1	1380350.JIAP01000002_gene4348	5.352e-174	556.0	COG1653@1|root,COG1653@2|Bacteria,1P3B0@1224|Proteobacteria,2TVAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_7521636_3	1298858.AUEL01000001_gene4827	5.417e-123	404.0	COG1609@1|root,COG1609@2|Bacteria,1P1Q3@1224|Proteobacteria,2TSER@28211|Alphaproteobacteria,43JM9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	transcriptional	rafR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS3_k127_7521636_5	1188256.BASI01000005_gene2123	4.544e-99	332.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,3FD0V@34008|Rhodovulum	28211|Alphaproteobacteria	S	Inhibitor of apoptosis-promoting Bax1	ybhL	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
TLS3_k127_7521636_0	1188256.BASI01000001_gene1295	1.404e-314	984.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,3FDQ6@34008|Rhodovulum	28211|Alphaproteobacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_7521636_4	1461694.ATO9_06410	1.295e-109	361.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria,2PCA5@252301|Oceanicola	28211|Alphaproteobacteria	Q	ATPases associated with a variety of cellular activities	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_753038_4	439496.RBY4I_670	1.72e-69	242.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_753038_3	1342301.JASD01000005_gene3894	1.643e-88	299.0	COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2V98A@28211|Alphaproteobacteria,3ZWCR@60136|Sulfitobacter	28211|Alphaproteobacteria	O	Peptidase family M48	-	-	-	ko:K07387	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M48
TLS3_k127_753038_0	349102.Rsph17025_1187	3.365e-202	638.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,1FBJY@1060|Rhodobacter	28211|Alphaproteobacteria	S	VWA domain containing CoxE-like protein	MA20_01305	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_753038_1	472175.EL18_03324	2.574e-101	337.0	COG0625@1|root,COG0625@2|Bacteria,1Q5XX@1224|Proteobacteria,2U18C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_N_3
TLS3_k127_753038_2	1461693.ATO10_03635	1.573e-88	314.0	2BWZZ@1|root,2Z7V7@2|Bacteria,1PFGK@1224|Proteobacteria,2TUWA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2927)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2927
TLS3_k127_753038_5	1469613.JT55_04580	1.896e-58	207.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria,3FEA7@34008|Rhodovulum	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_7530523_0	670292.JH26_08280	8.865e-192	619.0	COG1129@1|root,COG1172@1|root,COG1129@2|Bacteria,COG1172@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,1JZH6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TLS3_k127_7553784_1	1461693.ATO10_07076	5.685e-38	158.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TLS3_k127_7553784_0	1288298.rosmuc_02306	1.175e-139	462.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,46NRP@74030|Roseovarius	28211|Alphaproteobacteria	S	Peptidase, M16 family protein	MA20_05660	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_7553784_2	34007.IT40_05365	4.451e-37	143.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2PVZS@265|Paracoccus	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_760931_0	411684.HPDFL43_03084	1.746e-202	638.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2TSXN@28211|Alphaproteobacteria,43J16@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Urate oxidase N-terminal	MA20_17625	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
TLS3_k127_760931_4	1121271.AUCM01000003_gene1315	1.178e-136	443.0	COG0583@1|root,COG0583@2|Bacteria,1MVJ7@1224|Proteobacteria,2TT9Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_760931_5	1122218.KB893669_gene1571	1.212e-117	404.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSK0@28211|Alphaproteobacteria,1JTJ8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS3_k127_760931_7	909943.HIMB100_00023680	2.796e-72	253.0	COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria,4BPVS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K18335	ko00051,ko01120,map00051,map01120	-	R10690	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
TLS3_k127_760931_1	1122132.AQYH01000004_gene1464	3.597e-192	619.0	COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,2TUCZ@28211|Alphaproteobacteria,4BC6W@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	MA20_37650	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_760931_6	1126627.BAWE01000004_gene4678	1.382e-98	332.0	COG1175@1|root,COG1175@2|Bacteria,1MU84@1224|Proteobacteria,2TRM5@28211|Alphaproteobacteria,3JUVD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17316	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
TLS3_k127_760931_3	1122132.AQYH01000004_gene1462	2.649e-151	483.0	COG0395@1|root,COG0395@2|Bacteria,1MUT9@1224|Proteobacteria,2TRQ0@28211|Alphaproteobacteria,4B797@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC transporter permease	MA20_37640	-	-	ko:K17317	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
TLS3_k127_760931_2	536019.Mesop_6006	1.261e-175	557.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43HSD@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS3_k127_760931_8	1500890.JQNL01000001_gene1798	1.963e-26	110.0	COG1028@1|root,COG1028@2|Bacteria,1MXTP@1224|Proteobacteria,1RYTY@1236|Gammaproteobacteria,1X66B@135614|Xanthomonadales	135614|Xanthomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_7640091_0	1188256.BASI01000001_gene585	9.158e-141	457.0	COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2TT83@28211|Alphaproteobacteria,3FE4Q@34008|Rhodovulum	28211|Alphaproteobacteria	O	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_3,AAA_5
TLS3_k127_7640091_1	1297570.MESS4_280062	5.362e-119	403.0	COG3614@1|root,COG3920@1|root,COG3614@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U4QM@28211|Alphaproteobacteria,43IIM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	CHASE	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HWE_HK
TLS3_k127_764301_2	1353537.TP2_03040	5.149e-38	144.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,2XKV6@285107|Thioclava	28211|Alphaproteobacteria	I	Malonyl CoA-acyl carrier protein transacylase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
TLS3_k127_764301_0	314256.OG2516_02194	2.934e-113	369.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,2PDGV@252301|Oceanicola	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_764301_3	1188256.BASI01000002_gene3794	4.198e-33	130.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2UBWW@28211|Alphaproteobacteria,3FD7I@34008|Rhodovulum	28211|Alphaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS3_k127_764301_4	56110.Oscil6304_0050	4.583e-18	95.0	COG2340@1|root,COG2931@1|root,COG2340@2|Bacteria,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1H84J@1150|Oscillatoriales	1117|Cyanobacteria	Q	RTX toxins and related Ca2 binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	CAP,HemolysinCabind
TLS3_k127_764301_1	1469613.JT55_03980	5.629e-44	161.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,3FCQ4@34008|Rhodovulum	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS3_k127_7649409_0	349102.Rsph17025_1155	1.539e-268	837.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1FCEB@1060|Rhodobacter	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_16805	-	-	ko:K18138,ko:K18307	ko01501,ko01503,ko02024,map01501,map01503,map02024	M00644,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.20,2.A.6.2.32	-	-	ACR_tran
TLS3_k127_7649409_2	349102.Rsph17025_1154	3.047e-132	433.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,1FCCU@1060|Rhodobacter	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
TLS3_k127_7649409_1	1317124.DW2_03334	3.272e-184	589.0	COG0382@1|root,COG0560@1|root,COG0382@2|Bacteria,COG0560@2|Bacteria,1MXCM@1224|Proteobacteria,2TS0Z@28211|Alphaproteobacteria,2XN8F@285107|Thioclava	28211|Alphaproteobacteria	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	HAD,UbiA
TLS3_k127_7649409_3	1280952.HJA_13645	3.335e-18	91.0	COG2246@1|root,COG2246@2|Bacteria,1RJUK@1224|Proteobacteria,2U9QZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS3_k127_7654220_4	1367847.JCM7686_1874	1.32e-11	70.0	COG2825@1|root,COG2825@2|Bacteria,1MZ4B@1224|Proteobacteria,2UC2P@28211|Alphaproteobacteria,2PWTK@265|Paracoccus	28211|Alphaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	-	-	-	-	-	-	-	-	-	OmpH
TLS3_k127_7654220_3	367336.OM2255_03725	7.048e-56	202.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
TLS3_k127_7654220_0	1207063.P24_10505	5.307e-99	329.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,2JPHM@204441|Rhodospirillales	204441|Rhodospirillales	I	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep,Hexapep_2
TLS3_k127_7654220_2	272943.RSP_2715	8.191e-67	237.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,2U4AB@28211|Alphaproteobacteria,1FBQH@1060|Rhodobacter	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1009)	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
TLS3_k127_7654220_1	34007.IT40_15565	1.521e-78	277.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria,2PV4Y@265|Paracoccus	28211|Alphaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
TLS3_k127_7659363_0	1231392.OCGS_2417	1.093e-158	509.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
TLS3_k127_7659363_2	1449350.OCH239_14085	3.405e-50	183.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,4KMRQ@93682|Roseivivax	28211|Alphaproteobacteria	P	subunit of a heme lyase	cycL	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
TLS3_k127_7659363_1	1469613.JT55_14370	1.494e-122	404.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,3FCJ1@34008|Rhodovulum	28211|Alphaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS3_k127_7680017_2	1415756.JQMY01000001_gene3304	3.707e-93	312.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria,2PD20@252301|Oceanicola	28211|Alphaproteobacteria	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
TLS3_k127_7680017_3	519989.ECTPHS_08176	6.834e-30	130.0	COG5012@1|root,COG5012@2|Bacteria,1RJN6@1224|Proteobacteria	1224|Proteobacteria	S	B12-binding	aerR	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
TLS3_k127_7680017_1	314256.OG2516_13721	1.986e-97	325.0	COG0765@1|root,COG0765@2|Bacteria,1PF3S@1224|Proteobacteria,2V8AY@28211|Alphaproteobacteria,2PFP2@252301|Oceanicola	28211|Alphaproteobacteria	P	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
TLS3_k127_7680017_0	314256.OG2516_13716	5.551e-125	407.0	COG0834@1|root,COG0834@2|Bacteria,1NK96@1224|Proteobacteria,2TS1H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	amino acid	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS3_k127_7680017_4	195105.CN97_07240	2.973e-17	96.0	COG3861@1|root,COG3861@2|Bacteria,1N0R6@1224|Proteobacteria,2U9AS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
TLS3_k127_7683318_0	1469613.JT55_00510	1.767e-53	194.0	COG1596@1|root,COG1596@2|Bacteria,1PK0X@1224|Proteobacteria,2V85W@28211|Alphaproteobacteria,3FEKR@34008|Rhodovulum	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	-	-	-	-	-	-	-	-	-	Poly_export,SLBB
TLS3_k127_7683318_2	987059.RBXJA2T_09974	1.185e-06	58.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,2VVFW@28216|Betaproteobacteria,1KME8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
TLS3_k127_7683318_1	395492.Rleg2_2974	3.111e-36	143.0	COG0707@1|root,COG0707@2|Bacteria,1RJH9@1224|Proteobacteria,2UCZ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Oligosaccharide biosynthesis protein Alg14 like	pssD	-	-	-	-	-	-	-	-	-	-	-	Alg14
TLS3_k127_7684244_1	1246459.KB898355_gene4213	6.258e-62	226.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,4B9FX@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS3_k127_7684244_2	999549.KI421513_gene2342	4.151e-58	217.0	COG1664@1|root,COG1664@2|Bacteria,1MUS9@1224|Proteobacteria,2TSAA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_7684244_3	1156935.QWE_22726	6.769e-33	145.0	COG4635@1|root,COG4635@2|Bacteria,1RAH2@1224|Proteobacteria,2UB32@28211|Alphaproteobacteria,4BJBU@82115|Rhizobiaceae	28211|Alphaproteobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
TLS3_k127_7684244_0	768671.ThimaDRAFT_2701	6.572e-169	545.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria,1X08Q@135613|Chromatiales	135613|Chromatiales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS3_k127_7693626_5	314278.NB231_02698	1.446e-43	183.0	COG1874@1|root,COG1874@2|Bacteria,1PUBC@1224|Proteobacteria,1TKC7@1236|Gammaproteobacteria,1X1SP@135613|Chromatiales	135613|Chromatiales	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7693626_4	1446473.JHWH01000009_gene357	1.487e-122	422.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Type I secretion membrane fusion protein, HlyD	aprE	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
TLS3_k127_7693626_1	272943.RSP_1119	2.869e-201	657.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria,1FB0D@1060|Rhodobacter	28211|Alphaproteobacteria	V	TIGRFAM type I secretion system	wgdA	-	-	ko:K06148,ko:K16299	ko02010,map02010	M00571	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1,3.A.1.110.10	-	-	ABC_membrane,ABC_tran
TLS3_k127_7693626_0	1446473.JHWH01000009_gene355	6.607e-221	694.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2TUJE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM glycosyl transferase group 1	wgeG	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_7693626_2	272943.RSP_1117	8.906e-192	632.0	COG0616@1|root,COG1216@1|root,COG0616@2|Bacteria,COG1216@2|Bacteria,1R6ED@1224|Proteobacteria,2U4NA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	Glycosyl transferase, family 2	wgeF	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7693626_3	272943.RSP_1116	2.024e-146	478.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2V835@28211|Alphaproteobacteria,1FC7C@1060|Rhodobacter	1224|Proteobacteria	H	PFAM Glycosyl transferases group 1	wgeD	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
TLS3_k127_7715537_4	426355.Mrad2831_0971	4.986e-07	51.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria,2TST3@28211|Alphaproteobacteria,1JSWB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Winged helix DNA-binding domain	MA20_27725	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,MarR_2
TLS3_k127_7715537_2	1502724.FF80_01970	6.135e-08	65.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TTBX@28211|Alphaproteobacteria,3N8UK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_7715537_0	1038859.AXAU01000001_gene3518	5.781e-43	171.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,2TSXC@28211|Alphaproteobacteria,3K61X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_7715537_3	56110.Oscil6304_2599	2.869e-07	63.0	COG2823@1|root,COG2885@1|root,COG2823@2|Bacteria,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1H7DH@1150|Oscillatoriales	1117|Cyanobacteria	M	Outer membrane protein, OmpA MotB, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BON,OmpA
TLS3_k127_7715537_1	1423144.Gal_02546	2.418e-19	88.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,34EDR@302485|Phaeobacter	28211|Alphaproteobacteria	L	UvrD/REP helicase N-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_7746058_6	1500301.JQMF01000004_gene3663	2.243e-13	74.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TST2@28211|Alphaproteobacteria,4BA0V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Belongs to the DEAD box helicase family	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
TLS3_k127_7746058_3	1569209.BBPH01000171_gene454	1.558e-98	323.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,2PUSA@265|Paracoccus	28211|Alphaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS3_k127_7746058_5	1122132.AQYH01000003_gene3047	1.612e-29	130.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria,4BANQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377,ko:K16554	ko00051,ko00520,ko01100,ko05111,map00051,map00520,map01100,map05111	-	R05692	RC01014	ko00000,ko00001,ko01000,ko02000	8.A.3.1	-	-	Epimerase
TLS3_k127_7746058_4	272943.RSP_0316	1.005e-57	210.0	COG2197@1|root,COG2197@2|Bacteria,1RJPI@1224|Proteobacteria,2UAYT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS3_k127_7746058_1	266834.SM_b21078	2.981e-131	430.0	COG0438@1|root,COG0438@2|Bacteria,1MWJ9@1224|Proteobacteria,2UQCX@28211|Alphaproteobacteria,4BM9X@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
TLS3_k127_7746058_2	536019.Mesop_2976	1.099e-100	345.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,2U16K@28211|Alphaproteobacteria,43NQR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_7746058_0	69279.BG36_22225	5.684e-164	525.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2U0DX@28211|Alphaproteobacteria,43IYU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_7752326_3	1410620.SHLA_47c000360	2.084e-16	85.0	COG3415@1|root,COG3415@2|Bacteria,1RM6K@1224|Proteobacteria,2UDU9@28211|Alphaproteobacteria,4BFEQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_IS630
TLS3_k127_7752326_0	1547437.LL06_26180	3.831e-89	304.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2VBH8@28211|Alphaproteobacteria,43P72@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
TLS3_k127_7752326_1	398580.Dshi_2135	9.564e-63	224.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_27940	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_7752326_2	1449350.OCH239_00925	8.491e-20	89.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,4KKSY@93682|Roseivivax	28211|Alphaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS3_k127_7780664_1	1469613.JT55_13990	5.505e-123	405.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2TRA7@28211|Alphaproteobacteria,3FCYE@34008|Rhodovulum	28211|Alphaproteobacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS3_k127_7780664_0	1123501.KB902282_gene2457	1.517e-212	679.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	glycolate oxidase iron-sulfur subunit	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
TLS3_k127_7780664_2	1417296.U879_04365	9.039e-09	64.0	COG3591@1|root,COG3591@2|Bacteria,1MXUN@1224|Proteobacteria,2TT3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG3591 V8-like Glu-specific endopeptidase	blaSE	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
TLS3_k127_7796_2	1123360.thalar_02036	2.662e-05	48.0	COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	grp	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS3_k127_7796_0	1342301.JASD01000005_gene3836	3.206e-157	508.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,3ZV7P@60136|Sulfitobacter	28211|Alphaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
TLS3_k127_7796_1	1380380.JIAX01000010_gene144	1.346e-17	97.0	2CAHY@1|root,32RRF@2|Bacteria,1MZVR@1224|Proteobacteria,2UBQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2849)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2849
TLS3_k127_7805601_1	1417296.U879_04680	2.443e-107	353.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS3_k127_7805601_2	1122603.ATVI01000007_gene1624	6.444e-13	76.0	COG5001@1|root,COG5012@1|root,COG5001@2|Bacteria,COG5012@2|Bacteria,1QWTD@1224|Proteobacteria,1T2XV@1236|Gammaproteobacteria,1XD7B@135614|Xanthomonadales	135614|Xanthomonadales	T	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
TLS3_k127_7805601_4	397945.Aave_4041	4.449e-05	52.0	COG5001@1|root,COG5001@2|Bacteria,1QZZT@1224|Proteobacteria,2WHQX@28216|Betaproteobacteria,4AK0V@80864|Comamonadaceae	28216|Betaproteobacteria	T	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
TLS3_k127_7805601_0	1449351.RISW2_10180	5.233e-147	474.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,4KM1Z@93682|Roseivivax	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_7805601_3	351016.RAZWK3B_03875	2.982e-09	68.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2U703@28211|Alphaproteobacteria,2P2RN@2433|Roseobacter	28211|Alphaproteobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 1	ppaX	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_7806405_4	985054.JQEZ01000003_gene1635	0.0001739	50.0	2EM2Y@1|root,33ESF@2|Bacteria,1R3N4@1224|Proteobacteria,2U04A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycine zipper 2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
TLS3_k127_7806405_1	272942.RCAP_rcc03109	3.917e-142	466.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,1FBGN@1060|Rhodobacter	28211|Alphaproteobacteria	H	PFAM aminotransferase	MA20_39235	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS3_k127_7806405_0	367336.OM2255_06305	1.854e-185	600.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_7806405_2	420324.KI911947_gene5501	5.821e-68	257.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS3_k127_7806405_3	391595.RLO149_c032190	8.844e-15	79.0	COG2931@1|root,COG4990@1|root,COG2931@2|Bacteria,COG4990@2|Bacteria,1R7K3@1224|Proteobacteria,2UC6C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	G8 domain	-	-	-	-	-	-	-	-	-	-	-	-	G8
TLS3_k127_781_6	1122962.AULH01000007_gene1979	1.271e-10	64.0	COG1381@1|root,COG1381@2|Bacteria,1MVEJ@1224|Proteobacteria,2TTYW@28211|Alphaproteobacteria,36Y48@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Recombination protein O C terminal	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS3_k127_781_0	1122218.KB893654_gene1938	9.345e-247	773.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,1JRPH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase type 2 domain	mcd	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_781_1	349102.Rsph17025_0354	2.852e-221	694.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,1FBI6@1060|Rhodobacter	28211|Alphaproteobacteria	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS3_k127_781_3	1121271.AUCM01000011_gene2032	5.445e-150	496.0	2DC0C@1|root,2ZC6W@2|Bacteria,1QZV7@1224|Proteobacteria,2TYEG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_781_4	1417296.U879_08155	5.587e-89	297.0	2DBCJ@1|root,2Z8E3@2|Bacteria,1MXMX@1224|Proteobacteria,2U0E4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amino acid synthesis	-	-	-	-	-	-	-	-	-	-	-	-	AA_synth
TLS3_k127_781_5	1417296.U879_08160	9.738e-75	275.0	COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,2TTG1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	ApbE
TLS3_k127_781_2	935261.JAGL01000005_gene3326	1.947e-183	579.0	COG2816@1|root,COG2816@2|Bacteria,1MV1F@1224|Proteobacteria,2TTRT@28211|Alphaproteobacteria,43I51@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	COG1180 Pyruvate-formate lyase-activating enzyme	MA20_26535	-	1.3.7.1	ko:K20449	ko00760,ko01120,map00760,map01120	-	R03164	RC02422	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_7816148_4	935848.JAEN01000001_gene3439	2.701e-72	245.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRJV@28211|Alphaproteobacteria,2PW2V@265|Paracoccus	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	ssdA	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS3_k127_7816148_1	1336243.JAEA01000003_gene2467	5.27e-170	541.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,1JT1P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	mdh1	-	1.1.1.1,1.1.1.61	ko:K00001,ko:K00043	ko00010,ko00071,ko00350,ko00625,ko00626,ko00650,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	-	R00623,R00754,R01644,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
TLS3_k127_7816148_5	1469613.JT55_02950	6.241e-45	173.0	COG3932@1|root,COG3932@2|Bacteria,1N0FN@1224|Proteobacteria,2U95C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC-type transport system, permease components	-	-	-	-	-	-	-	-	-	-	-	-	ExoD
TLS3_k127_7816148_3	1297569.MESS2_1060014	3.504e-76	263.0	COG2120@1|root,COG2120@2|Bacteria,1RF7P@1224|Proteobacteria,2U8IA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS3_k127_7816148_0	1380350.JIAP01000002_gene4352	4.196e-209	660.0	COG1626@1|root,COG1626@2|Bacteria,1QU4C@1224|Proteobacteria,2TSRJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
TLS3_k127_7816148_2	1040987.AZUY01000004_gene3187	1.398e-78	265.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TVQ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	-	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
TLS3_k127_7861842_3	935565.JAEM01000001_gene303	7.081e-26	108.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,2PWUQ@265|Paracoccus	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_7861842_2	570952.ATVH01000014_gene2235	2.596e-57	204.0	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2TURT@28211|Alphaproteobacteria,2JQTU@204441|Rhodospirillales	204441|Rhodospirillales	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
TLS3_k127_7861842_4	1317118.ATO8_20259	0.0004335	46.0	COG0725@1|root,COG0725@2|Bacteria,1PT1P@1224|Proteobacteria,2U42Z@28211|Alphaproteobacteria,4KMC9@93682|Roseivivax	28211|Alphaproteobacteria	P	Molybdate ABC transporter substrate-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS3_k127_7861842_0	1240349.ANGC01000027_gene3918	9.434e-109	363.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FU5I@85025|Nocardiaceae	201174|Actinobacteria	V	ABC transporter	drrA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS3_k127_7861842_1	1479238.JQMZ01000001_gene2489	5.28e-72	247.0	COG0842@1|root,COG0842@2|Bacteria,1R3XD@1224|Proteobacteria,2U1FZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS3_k127_7874514_4	1449350.OCH239_01945	1.658e-36	143.0	COG2068@1|root,COG2068@2|Bacteria,1RH9W@1224|Proteobacteria,2U9V3@28211|Alphaproteobacteria,4KMS4@93682|Roseivivax	28211|Alphaproteobacteria	S	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
TLS3_k127_7874514_2	1123247.AUIJ01000002_gene2074	3.361e-72	247.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS3_k127_7874514_3	1231392.OCGS_2359	1.033e-55	201.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2U5GT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
TLS3_k127_7874514_0	670292.JH26_10560	1.412e-144	478.0	COG2770@1|root,COG3920@1|root,COG2770@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U0N4@28211|Alphaproteobacteria,1JSNY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HWE_HK,dCache_1
TLS3_k127_7874514_1	1469613.JT55_17550	3.936e-99	347.0	COG4645@1|root,COG4645@2|Bacteria,1PDDJ@1224|Proteobacteria,2V99A@28211|Alphaproteobacteria,3FEG7@34008|Rhodovulum	28211|Alphaproteobacteria	S	OpgC protein	-	-	-	-	-	-	-	-	-	-	-	-	OpgC_C
TLS3_k127_7874514_6	1280950.HJO_00325	1.446e-23	110.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_7874514_5	1121271.AUCM01000003_gene1584	1.103e-26	112.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS3_k127_7879444_2	1417296.U879_18575	2.353e-212	672.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_7879444_0	272943.RSP_0965	0.0	1608.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,1FAYK@1060|Rhodobacter	28211|Alphaproteobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E1	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS3_k127_7879444_6	1417296.U879_18585	1.827e-163	517.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS3_k127_7879444_3	1188256.BASI01000005_gene2164	2.945e-204	641.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,3FCJK@34008|Rhodovulum	28211|Alphaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS3_k127_7879444_10	1088721.NSU_2901	1.212e-43	166.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2UC22@28211|Alphaproteobacteria,2K541@204457|Sphingomonadales	204457|Sphingomonadales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
TLS3_k127_7879444_4	1123501.KB902312_gene2731	8.825e-176	557.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS3_k127_7879444_8	246200.SPO0350	6.464e-76	268.0	COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2TU6M@28211|Alphaproteobacteria,4NAMX@97050|Ruegeria	28211|Alphaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_7879444_11	391937.NA2_04226	2.636e-39	163.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,2UBR4@28211|Alphaproteobacteria,43KY0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Small Multidrug Resistance protein	sugE	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
TLS3_k127_7879444_15	1342299.Z947_1761	8.879e-19	93.0	2EMKN@1|root,3339E@2|Bacteria,1N9SW@1224|Proteobacteria,2UF94@28211|Alphaproteobacteria,3ZXUE@60136|Sulfitobacter	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7879444_7	1122218.KB893653_gene1086	3.616e-97	331.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,1JU0M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	citE	-	3.1.2.30,4.1.3.34	ko:K01644,ko:K14451	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R10612	RC00004,RC00014,RC00067,RC01118	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TLS3_k127_7879444_9	1449350.OCH239_17650	1.316e-61	233.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2TQWY@28211|Alphaproteobacteria,4KK6U@93682|Roseivivax	28211|Alphaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
TLS3_k127_7879444_14	252305.OB2597_09569	2.195e-26	109.0	COG5515@1|root,COG5515@2|Bacteria,1N87I@1224|Proteobacteria,2UF35@28211|Alphaproteobacteria,2PEPF@252301|Oceanicola	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1737)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1737
TLS3_k127_7879444_5	349102.Rsph17025_0085	1.887e-164	522.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,1FAQI@1060|Rhodobacter	28211|Alphaproteobacteria	I	dehydratase	mch	GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS3_k127_7879444_12	414684.RC1_3939	1.105e-34	152.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,2JTDG@204441|Rhodospirillales	204441|Rhodospirillales	C	COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS3_k127_7879444_13	1122218.KB893663_gene1616	5.312e-34	134.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,1JVID@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	TIGRFAM succinate dehydrogenase, hydrophobic membrane anchor protein	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS3_k127_7879444_1	1469613.JT55_14615	0.0	1046.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,3FCMC@34008|Rhodovulum	28211|Alphaproteobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS3_k127_7887773_2	766499.C357_05613	1.093e-38	150.0	COG1539@1|root,COG1539@2|Bacteria,1MY5Q@1224|Proteobacteria,2TRVX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	4HFCP_synth,FolB
TLS3_k127_7887773_3	1415756.JQMY01000001_gene388	2.02e-14	82.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
TLS3_k127_7887773_1	1121271.AUCM01000004_gene1212	5.997e-47	179.0	COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,2TT15@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Cell wall hydrolyses involved in spore germination	sleB	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
TLS3_k127_7887773_0	1316936.K678_10781	2.146e-81	282.0	COG1703@1|root,COG1703@2|Bacteria,1R44P@1224|Proteobacteria,2TW2E@28211|Alphaproteobacteria,2JR6W@204441|Rhodospirillales	204441|Rhodospirillales	E	periplasmic protein kinase ArgK and related GTPases of G3E family	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS3_k127_7906788_0	765912.Thimo_3092	8.153e-74	272.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1WX1E@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_6,TPR_8
TLS3_k127_7906788_1	156889.Mmc1_0922	0.0004975	47.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2TTW6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS3_k127_791356_1	398580.Dshi_2609	1.506e-148	475.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
TLS3_k127_791356_2	349102.Rsph17025_1573	3.758e-115	387.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,1FB71@1060|Rhodobacter	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_791356_3	644076.SCH4B_1571	3.492e-13	78.0	2E56U@1|root,32ZZI@2|Bacteria,1N750@1224|Proteobacteria,2UF4W@28211|Alphaproteobacteria,4NCC3@97050|Ruegeria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_791356_0	1105367.CG50_06520	6.001e-169	543.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
TLS3_k127_7966143_2	195105.CN97_02280	8.734e-79	271.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2U7DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG2148 Sugar transferases involved in lipopolysaccharide synthesis	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
TLS3_k127_7966143_0	1040982.AXAL01000038_gene143	4.855e-112	368.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2U1EJ@28211|Alphaproteobacteria,43JYN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	AAA domain	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
TLS3_k127_7966143_1	1231392.OCGS_2642	4.505e-98	351.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2TTBW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
TLS3_k127_798813_0	1547437.LL06_07215	1.866e-144	475.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSZP@28211|Alphaproteobacteria,43IKW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_798813_2	1547437.LL06_07210	8.205e-90	314.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,43H07@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	branched-chain amino acid	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS3_k127_798813_1	1547437.LL06_07205	2.15e-108	356.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,43JHQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995,ko:K11957	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_8002919_7	1123247.AUIJ01000014_gene1183	8.417e-22	96.0	COG4311@1|root,COG4311@2|Bacteria,1N8ED@1224|Proteobacteria,2UFIN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Sarcosine oxidase, delta subunit	soxD_2	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
TLS3_k127_8002919_4	935557.ATYB01000008_gene4787	1.112e-90	314.0	COG1609@1|root,COG1609@2|Bacteria,1N2TE@1224|Proteobacteria,2TV4Z@28211|Alphaproteobacteria,4B98H@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Periplasmic binding protein-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS3_k127_8002919_2	935557.ATYB01000008_gene4786	1.365e-155	498.0	COG0346@1|root,COG0346@2|Bacteria,1MUWY@1224|Proteobacteria,2TTMJ@28211|Alphaproteobacteria,4BAKV@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	xylE	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS3_k127_8002919_6	530564.Psta_0072	3.252e-26	113.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_8002919_0	1123247.AUIJ01000014_gene1182	7.587e-214	670.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Sarcosine oxidase, beta subunit	soxB1	-	1.5.3.1,1.5.99.5	ko:K00303,ko:K22084	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS3_k127_8002919_8	530564.Psta_0072	9.505e-19	92.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_8002919_3	1211115.ALIQ01000028_gene750	2.857e-150	481.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria,3NCHF@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
TLS3_k127_8002919_1	1211115.ALIQ01000028_gene751	8.953e-192	616.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	-	-	-	ko:K21393	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctM
TLS3_k127_8002919_5	935261.JAGL01000013_gene3601	6.69e-58	206.0	COG3090@1|root,COG3090@2|Bacteria,1RIQN@1224|Proteobacteria,2U7WV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	TRAP-type C4-dicarboxylate transport system small permease component	yiaM	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
TLS3_k127_8008150_3	1337093.MBE-LCI_0428	3.355e-104	348.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,2P8K8@245186|Loktanella	28211|Alphaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS3_k127_8008150_2	290400.Jann_3870	3.019e-121	399.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2TSZM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_8008150_0	1192868.CAIU01000021_gene3181	6.046e-138	445.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,43I2S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Inosine-uridine preferring nucleoside hydrolase	rihA	GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
TLS3_k127_8008150_4	395019.Bmul_3664	1.156e-54	198.0	COG1896@1|root,COG1896@2|Bacteria,1MXEZ@1224|Proteobacteria,2VNB7@28216|Betaproteobacteria,1K7KQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
TLS3_k127_8008150_5	1123247.AUIJ01000003_gene1923	6.778e-44	167.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
TLS3_k127_8008150_6	1188256.BASI01000001_gene597	1.477e-27	119.0	2AJ3A@1|root,319MP@2|Bacteria,1RHJE@1224|Proteobacteria,2UABS@28211|Alphaproteobacteria,3FE7F@34008|Rhodovulum	28211|Alphaproteobacteria	O	Protein of unknown function (DUF3035)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3035
TLS3_k127_8008150_1	398580.Dshi_0363	1.879e-133	434.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
TLS3_k127_8032491_8	290397.Adeh_0894	2.106e-09	63.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,42NGX@68525|delta/epsilon subdivisions,2WJC0@28221|Deltaproteobacteria,2YWXY@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAF987.Gmet_2434	E1-E2_ATPase,Hydrolase
TLS3_k127_8032491_6	391613.RTM1035_09354	1.235e-48	190.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,46QW4@74030|Roseovarius	28211|Alphaproteobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
TLS3_k127_8032491_5	1122614.JHZF01000011_gene2078	1.084e-49	195.0	COG5061@1|root,COG5061@2|Bacteria,1RHE2@1224|Proteobacteria,2UADK@28211|Alphaproteobacteria,2PEC7@252301|Oceanicola	28211|Alphaproteobacteria	OU	Protein of unknown function (DUF3307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3307
TLS3_k127_8032491_7	314256.OG2516_03855	2.616e-37	149.0	COG1595@1|root,COG1595@2|Bacteria,1QYPZ@1224|Proteobacteria	1224|Proteobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8032491_3	1123501.KB902299_gene3887	2.901e-61	214.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FeS assembly SUF system protein	mrp	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS3_k127_8032491_0	349102.Rsph17025_1156	2.238e-204	646.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,1FBHG@1060|Rhodobacter	28211|Alphaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
TLS3_k127_8032491_2	1082931.KKY_3142	1.039e-88	304.0	COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,2TTJ7@28211|Alphaproteobacteria,3N7MT@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Converts alpha-aldose to the beta-anomer	galM	GO:0003674,GO:0003824,GO:0004034,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
TLS3_k127_8032491_4	1446473.JHWH01000016_gene2267	1.472e-50	184.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,2PWYD@265|Paracoccus	28211|Alphaproteobacteria	S	Yqey-like protein	MA20_04985	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS3_k127_8032491_1	314271.RB2654_08257	4.223e-137	440.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
TLS3_k127_8047837_7	644076.SCH4B_1819	4.005e-07	51.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,4NBD2@97050|Ruegeria	28211|Alphaproteobacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS3_k127_8047837_0	195105.CN97_09890	0.0	1020.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	fadJ	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS3_k127_8047837_5	246200.SPO2104	1.056e-37	156.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,2U6K6@28211|Alphaproteobacteria,4NC8M@97050|Ruegeria	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_8047837_4	1469613.JT55_05075	4.507e-61	221.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,2VARS@28211|Alphaproteobacteria,3FEBA@34008|Rhodovulum	28211|Alphaproteobacteria	S	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_8047837_6	371731.Rsw2DRAFT_0540	2.052e-34	149.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria	1224|Proteobacteria	F	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_8047837_2	349102.Rsph17025_2295	3.966e-212	664.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria,1FBAV@1060|Rhodobacter	28211|Alphaproteobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_8047837_3	1469613.JT55_05085	4.247e-84	284.0	COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,2TR9W@28211|Alphaproteobacteria,3FD5U@34008|Rhodovulum	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	MA20_04615	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
TLS3_k127_8047837_1	1288298.rosmuc_00816	8.459e-274	854.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,46QHC@74030|Roseovarius	28211|Alphaproteobacteria	C	COG1960 Acyl-CoA dehydrogenases	MA20_19860	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS3_k127_8062140_1	1188256.BASI01000001_gene844	1.584e-119	401.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3FCKT@34008|Rhodovulum	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
TLS3_k127_8062140_0	1122180.Lokhon_00707	2.655e-238	766.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,2P8JE@245186|Loktanella	28211|Alphaproteobacteria	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS3_k127_8077385_1	1121918.ARWE01000001_gene2779	7.221e-56	214.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2WMD9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Hemolysin-type calcium-binding	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,HCBP_related,He_PIG,HemolysinCabind,Peptidase_M91,VWA_2
TLS3_k127_8077385_0	349102.Rsph17025_0962	5.072e-233	755.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2TS1X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Cellulose synthase	celA	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glycos_transf_2,PilZ
TLS3_k127_8080810_4	1317124.DW2_09546	4.884e-49	184.0	COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,2U0XJ@28211|Alphaproteobacteria,2XMWA@285107|Thioclava	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE7	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_8080810_6	1569209.BBPH01000142_gene3564	1.976e-37	144.0	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2UBV0@28211|Alphaproteobacteria,2PYSR@265|Paracoccus	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
TLS3_k127_8080810_1	314232.SKA53_06462	1.564e-126	426.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
TLS3_k127_8080810_5	1569209.BBPH01000142_gene3562	1.505e-47	181.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2TTIN@28211|Alphaproteobacteria,2PYNI@265|Paracoccus	28211|Alphaproteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
TLS3_k127_8080810_3	314232.SKA53_06472	2.433e-53	202.0	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2TVZ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
TLS3_k127_8080810_7	1246459.KB898369_gene941	1.242e-23	102.0	2DS8V@1|root,33F1N@2|Bacteria,1N80F@1224|Proteobacteria,2UHH8@28211|Alphaproteobacteria,4BGV0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2945)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2945
TLS3_k127_8080810_2	412597.AEPN01000004_gene3167	3.873e-108	355.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,2PUFI@265|Paracoccus	28211|Alphaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS3_k127_8080810_0	1469613.JT55_16130	1.566e-180	579.0	COG3106@1|root,COG3106@2|Bacteria,1MX6E@1224|Proteobacteria,2TR9Y@28211|Alphaproteobacteria,3FCNP@34008|Rhodovulum	28211|Alphaproteobacteria	S	YcjX-like family, DUF463	MA20_04550	-	-	ko:K06918	-	-	-	-	ko00000	-	-	-	DUF463
TLS3_k127_8080810_8	195105.CN97_09455	2.436e-08	67.0	COG3768@1|root,COG3768@2|Bacteria,1MU8S@1224|Proteobacteria,2TU53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	MA20_04555	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08990	-	-	-	-	ko00000	-	-	-	DUF697
TLS3_k127_8090535_4	1123501.KB902276_gene1147	2.108e-82	287.0	COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2TSDV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0524 Sugar kinases, ribokinase family	kdgK	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS3_k127_8090535_2	1122135.KB893135_gene895	2.575e-93	316.0	COG0697@1|root,COG0697@2|Bacteria,1MY2U@1224|Proteobacteria,2TV71@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
TLS3_k127_8090535_0	411684.HPDFL43_10107	8.972e-140	458.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,43GXT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	MA20_01870	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1,Sugar_tr
TLS3_k127_8090535_6	1353537.TP2_11315	1.65e-29	118.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,2XNM8@285107|Thioclava	28211|Alphaproteobacteria	K	Cold-shock protein	cspA4	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS3_k127_8090535_1	1123501.KB902313_gene2820	7.328e-108	360.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
TLS3_k127_8090535_5	1530186.JQEY01000006_gene3378	1.995e-43	162.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS3_k127_8090535_3	1530186.JQEY01000006_gene3376	3.605e-89	306.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
TLS3_k127_8109083_1	62928.azo3389	1.315e-12	69.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,2KUVW@206389|Rhodocyclales	206389|Rhodocyclales	M	UDP-glucose 4-epimerase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS3_k127_8109083_0	272942.RCAP_rcc01932	3.257e-87	302.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2VDAR@28211|Alphaproteobacteria,1FCIG@1060|Rhodobacter	28211|Alphaproteobacteria	M	Glycosyl transferase family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_4
TLS3_k127_8111014_3	935565.JAEM01000029_gene898	8.327e-58	203.0	COG3718@1|root,COG3718@2|Bacteria,1MWGD@1224|Proteobacteria,2TUJZ@28211|Alphaproteobacteria,2PVH4@265|Paracoccus	28211|Alphaproteobacteria	G	KduI/IolB family	iolB1	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS3_k127_8111014_1	189753.AXAS01000019_gene3466	2.112e-152	488.0	COG1082@1|root,COG1082@2|Bacteria,1MUQ0@1224|Proteobacteria,2TRXA@28211|Alphaproteobacteria,3JXSJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS3_k127_8111014_9	1530186.JQEY01000001_gene1390	2.703e-22	104.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2TR12@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the TPP enzyme family	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_8111014_7	1185652.USDA257_c25720	4.762e-33	137.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2TR12@28211|Alphaproteobacteria,4B9HZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the TPP enzyme family	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_8111014_0	34007.IT40_10365	0.0	1034.0	COG0524@1|root,COG3892@1|root,COG0524@2|Bacteria,COG3892@2|Bacteria,1MV6I@1224|Proteobacteria,2TTWN@28211|Alphaproteobacteria,2PU2Z@265|Paracoccus	28211|Alphaproteobacteria	G	Uncharacterized protein conserved in bacteria (DUF2090)	iolC	-	2.7.1.92	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R05661	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DUF2090,PfkB
TLS3_k127_8111014_2	1079460.ATTQ01000003_gene1500	7.562e-121	397.0	COG4130@1|root,COG4130@2|Bacteria,1PC6C@1224|Proteobacteria,2TUIJ@28211|Alphaproteobacteria,4BKZN@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	iolI	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS3_k127_8111014_4	1370122.JHXQ01000006_gene972	1.428e-56	199.0	COG0673@1|root,COG0673@2|Bacteria,1NQ54@1224|Proteobacteria,2U2MA@28211|Alphaproteobacteria,4BD3Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_8111014_11	935848.JAEN01000009_gene1608	1.321e-13	70.0	COG1082@1|root,COG1082@2|Bacteria,1NFRG@1224|Proteobacteria,2U16J@28211|Alphaproteobacteria,2PWAB@265|Paracoccus	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	ko:K06605	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
TLS3_k127_8111014_5	1185652.USDA257_c25660	3.385e-56	199.0	COG1082@1|root,COG1082@2|Bacteria,1NFRG@1224|Proteobacteria,2U16J@28211|Alphaproteobacteria,4BC08@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Sugar phosphate isomerases epimerases	iolH	-	-	ko:K06605	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
TLS3_k127_8111014_10	1446473.JHWH01000009_gene244	7.41e-18	92.0	2ADVW@1|root,313MV@2|Bacteria,1PSPK@1224|Proteobacteria,2V4T6@28211|Alphaproteobacteria,2PXTD@265|Paracoccus	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8111014_8	991905.SL003B_1008	2.321e-22	108.0	2DPDQ@1|root,331NY@2|Bacteria,1N8NC@1224|Proteobacteria,2UH3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8111014_6	1449350.OCH239_03935	2.892e-35	139.0	2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,2UC0T@28211|Alphaproteobacteria,4KMXE@93682|Roseivivax	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8112118_4	195105.CN97_09905	6.91e-26	112.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_19860	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS3_k127_8112118_3	501479.ACNW01000021_gene3752	2.702e-46	171.0	COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2U98M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS3_k127_8112118_5	1117943.SFHH103_03777	1.948e-14	77.0	2EKB8@1|root,33E1M@2|Bacteria,1NGBX@1224|Proteobacteria,2UMG6@28211|Alphaproteobacteria,4BGGG@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8112118_2	1417296.U879_02900	3.578e-48	191.0	COG2050@1|root,COG2050@2|Bacteria,1RHK6@1224|Proteobacteria,2U72Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	MA20_04725	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_8112118_1	1353537.TP2_08890	5.067e-71	249.0	COG2050@1|root,COG2050@2|Bacteria,1RITB@1224|Proteobacteria,2U58S@28211|Alphaproteobacteria,2XMQG@285107|Thioclava	28211|Alphaproteobacteria	Q	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT,4HBT_3
TLS3_k127_8112118_0	1461693.ATO10_09503	1.471e-168	537.0	COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,2TSKZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG0534 Na -driven multidrug efflux pump	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
TLS3_k127_8124622_1	1569209.BBPH01000022_gene323	1.824e-41	164.0	COG0501@1|root,COG0501@2|Bacteria,1R5XJ@1224|Proteobacteria,2UMYS@28211|Alphaproteobacteria,2PUP7@265|Paracoccus	28211|Alphaproteobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS3_k127_8124622_0	1120983.KB894570_gene1900	1.013e-57	205.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,1JP33@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Dehydroquinase class II	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS3_k127_8124622_2	349102.Rsph17025_2348	9.31e-05	46.0	COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2U9GK@28211|Alphaproteobacteria,1FC4K@1060|Rhodobacter	28211|Alphaproteobacteria	S	SOS response	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
TLS3_k127_8124651_2	1123229.AUBC01000013_gene2582	4.889e-55	199.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,3JYDJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS3_k127_8124651_0	1297569.MESS2_p100008	1.065e-140	457.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,43HD7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
TLS3_k127_8124651_1	1469613.JT55_16830	3.771e-61	217.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2U5HG@28211|Alphaproteobacteria,3FE2B@34008|Rhodovulum	28211|Alphaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
TLS3_k127_8125417_0	1188256.BASI01000001_gene689	4.329e-63	222.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TW0G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2,Reductase_C,Rieske
TLS3_k127_8125417_1	666509.RCA23_c03440	2.311e-56	202.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peroxiredoxin	pmpA	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
TLS3_k127_8135504_0	864069.MicloDRAFT_00013410	1.425e-83	289.0	28Z9U@1|root,2ZM1P@2|Bacteria,1RBFF@1224|Proteobacteria,2U5YY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8146513_4	195105.CN97_10155	2.025e-09	60.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,2TUGX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	BON,OmpA
TLS3_k127_8146513_5	1446473.JHWH01000022_gene3029	1.114e-05	53.0	2AI35@1|root,318GY@2|Bacteria,1RGYE@1224|Proteobacteria,2U9PN@28211|Alphaproteobacteria,2PXE4@265|Paracoccus	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8146513_2	1417296.U879_02430	3.906e-51	189.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2U73K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Molybdopterin converting factor, large subunit	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TLS3_k127_8146513_3	999549.KI421513_gene981	3.428e-31	124.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,281U9@191028|Leisingera	28211|Alphaproteobacteria	H	ThiS family	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
TLS3_k127_8146513_0	1337093.MBE-LCI_2426	1.9e-71	247.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,2P89U@245186|Loktanella	28211|Alphaproteobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS3_k127_8146513_1	1415756.JQMY01000001_gene1312	4.383e-65	225.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,2PD0E@252301|Oceanicola	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS3_k127_8158306_8	1097668.BYI23_C006360	3.926e-05	48.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2W03Z@28216|Betaproteobacteria,1KGN1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
TLS3_k127_8158306_7	1547437.LL06_21145	7.361e-31	136.0	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,2UF3V@28211|Alphaproteobacteria,43QTW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
TLS3_k127_8158306_5	1535287.JP74_17110	6.556e-57	203.0	COG1595@1|root,COG1595@2|Bacteria,1RBW4@1224|Proteobacteria,2VETF@28211|Alphaproteobacteria,3N9HY@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Sigma-70, region 4	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_8158306_6	1317118.ATO8_17030	3.354e-34	137.0	COG4852@1|root,COG4852@2|Bacteria,1MZHP@1224|Proteobacteria,2UBSF@28211|Alphaproteobacteria,4KNT5@93682|Roseivivax	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2177
TLS3_k127_8158306_0	314271.RB2654_03084	2.032e-208	655.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS3_k127_8158306_4	1417296.U879_12530	2.425e-57	206.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS3_k127_8158306_1	991905.SL003B_2573	5.03e-144	488.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,4BRD3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TLS3_k127_8158306_2	991905.SL003B_2572	8.895e-105	344.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,4BQHT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
TLS3_k127_8158306_3	991905.SL003B_2571	2.679e-104	345.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,4BS3D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS3_k127_8200682_0	1188256.BASI01000003_gene2759	1.641e-238	744.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,3FCVB@34008|Rhodovulum	28211|Alphaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS3_k127_8200682_1	1122614.JHZF01000016_gene473	6.796e-140	464.0	COG2203@1|root,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,2TWDZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HWE_HK,PAS_3,PAS_4,PAS_8
TLS3_k127_820108_4	349102.Rsph17025_2024	2.501e-30	124.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,1FB6A@1060|Rhodobacter	28211|Alphaproteobacteria	M	TIGRFAM type I secretion outer membrane protein, TolC family	bepC	-	-	ko:K12340,ko:K12535	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00327,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
TLS3_k127_820108_3	1411123.JQNH01000001_gene1301	2.76e-66	235.0	2DBA3@1|root,2Z80R@2|Bacteria,1RATB@1224|Proteobacteria,2U635@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_820108_2	571166.KI421509_gene4404	1.987e-120	397.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRW0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
TLS3_k127_820108_1	331869.BAL199_17393	1.601e-132	444.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,4BQ15@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS3_k127_820108_0	1411123.JQNH01000001_gene1298	3.568e-254	814.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_820108_5	298655.KI912266_gene2513	3.618e-14	87.0	COG1028@1|root,COG1028@2|Bacteria,2GX9R@201174|Actinobacteria,4EV2N@85013|Frankiales	201174|Actinobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	ko:K07535	ko00362,ko01120,ko01220,map00362,map01120,map01220	M00540	R05582	RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
TLS3_k127_8209143_0	1500301.JQMF01000011_gene2335	1.634e-114	375.0	COG0784@1|root,COG1595@1|root,COG0784@2|Bacteria,COG1595@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,4B8FY@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	response regulator	phyR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
TLS3_k127_8209143_1	1547437.LL06_22920	3.249e-56	211.0	COG3920@1|root,COG3920@2|Bacteria,1RBJF@1224|Proteobacteria,2U5SC@28211|Alphaproteobacteria,43ICN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase	tcrY	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_4
TLS3_k127_8209143_2	1317118.ATO8_11699	0.0004464	51.0	COG0784@1|root,COG4251@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,2TT77@28211|Alphaproteobacteria,4KMF0@93682|Roseivivax	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HWE_HK,PAS_2,PAS_3,PHY,Response_reg
TLS3_k127_8213804_0	195105.CN97_01470	3.014e-161	513.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS3_k127_8213804_1	391593.RCCS2_17286	2.015e-37	160.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,2P1YX@2433|Roseobacter	28211|Alphaproteobacteria	S	membrane metal-binding protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
TLS3_k127_8217776_2	388399.SSE37_22629	4.52e-139	450.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	homoserine dehydrogenase	hom	GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
TLS3_k127_8217776_0	1082933.MEA186_08668	1.793e-153	490.0	COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria,43I60@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	gluconolactonase	-	-	3.1.1.17	ko:K01053,ko:K14274	ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02427,R02933,R03751	RC00537,RC00713,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
TLS3_k127_8217776_1	371731.Rsw2DRAFT_3092	2.14e-145	481.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,2TR44@28211|Alphaproteobacteria,1FANP@1060|Rhodobacter	28211|Alphaproteobacteria	T	histidine kinase HAMP region domain protein	regM	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS3_k127_8217776_3	1121271.AUCM01000010_gene2413	3.462e-06	50.0	2DMKE@1|root,32S6E@2|Bacteria,1N0IU@1224|Proteobacteria,2UC7Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3572)	MA20_36230	-	-	-	-	-	-	-	-	-	-	-	DUF3572
TLS3_k127_8230929_0	1089552.KI911559_gene524	1.417e-83	291.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,2JQBI@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8
TLS3_k127_8230929_1	1229204.AMYY01000021_gene673	3.07e-64	228.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,4BQFJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS3_k127_8235095_0	195105.CN97_07210	9.329e-174	552.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtB	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
TLS3_k127_8235095_1	398580.Dshi_2697	1.614e-168	558.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2TTN2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
TLS3_k127_8235095_2	398580.Dshi_2698	2.588e-106	368.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2TQVJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	abc transporter atp-binding protein	urtD	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_8235095_3	1122929.KB908230_gene3690	6.041e-102	337.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2TS23@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter, (ATP-binding protein)	urtE	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
TLS3_k127_8235095_4	1120983.KB894570_gene1859	2.231e-06	52.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
TLS3_k127_8243506_0	272943.RSP_0632	2.892e-194	620.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,1FCMZ@1060|Rhodobacter	28211|Alphaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
TLS3_k127_8243506_1	1121271.AUCM01000008_gene3201	1.72e-74	253.0	COG5328@1|root,COG5328@2|Bacteria,1RA93@1224|Proteobacteria,2U741@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Belongs to the UPF0262 family	MA20_21090	-	-	-	-	-	-	-	-	-	-	-	UPF0262
TLS3_k127_8243506_2	1469613.JT55_15205	2.167e-69	237.0	COG0394@1|root,COG0394@2|Bacteria,1RANV@1224|Proteobacteria,2U5EE@28211|Alphaproteobacteria,3FDEY@34008|Rhodovulum	28211|Alphaproteobacteria	T	Low molecular weight phosphatase family	MA20_21085	-	1.20.4.1,3.1.3.48	ko:K01104,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS3_k127_8243506_4	595536.ADVE02000001_gene3430	7.396e-32	132.0	COG3685@1|root,COG3685@2|Bacteria,1REKN@1224|Proteobacteria,2U66P@28211|Alphaproteobacteria,36Z20@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF892)	MA20_08255	-	-	-	-	-	-	-	-	-	-	-	DUF892
TLS3_k127_8243506_3	1380367.JIBC01000004_gene2003	1.33e-37	143.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,3ZXV1@60136|Sulfitobacter	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
TLS3_k127_8243506_5	349102.Rsph17025_0600	6.737e-24	104.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,1FBSJ@1060|Rhodobacter	28211|Alphaproteobacteria	D	TIGRFAM maf protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
TLS3_k127_8243607_1	1122218.KB893653_gene1064	6.323e-169	539.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,1JSTK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS3_k127_8243607_0	1417296.U879_17290	2e-323	1005.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS3_k127_8249755_4	1469613.JT55_03460	1.432e-57	207.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,3FDBC@34008|Rhodovulum	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	MA20_15575	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
TLS3_k127_8249755_5	1395571.TMS3_0123180	2.009e-53	208.0	COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,1S91P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_8249755_0	1122180.Lokhon_01467	1.659e-117	386.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,2P87W@245186|Loktanella	28211|Alphaproteobacteria	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS3_k127_8249755_3	1121271.AUCM01000001_gene3578	1.638e-73	250.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2U5CQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	dehydratase	phaJ	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
TLS3_k127_8249755_1	371731.Rsw2DRAFT_2453	7.254e-100	338.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria,1FB9D@1060|Rhodobacter	28211|Alphaproteobacteria	G	HAD-superfamily subfamily IIA hydrolase like protein	MA20_05625	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
TLS3_k127_8249755_2	1123501.KB902276_gene1432	2.159e-81	275.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS3_k127_8267817_6	1231392.OCGS_1777	2.173e-17	82.0	COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1956 GAF domain-containing protein	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
TLS3_k127_8267817_5	63737.Npun_F2820	2.029e-29	129.0	295GN@1|root,2ZSUA@2|Bacteria,1G61Q@1117|Cyanobacteria,1HNK5@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8267817_2	314232.SKA53_03051	2.014e-93	316.0	COG2236@1|root,COG2236@2|Bacteria,1MWNE@1224|Proteobacteria,2TUXK@28211|Alphaproteobacteria,2P7UY@245186|Loktanella	28211|Alphaproteobacteria	F	Acts on guanine, xanthine and to a lesser extent hypoxanthine	gpt	-	2.4.2.22	ko:K00769	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS3_k127_8267817_3	314256.OG2516_03795	3.184e-62	232.0	COG1280@1|root,COG1280@2|Bacteria,1MX0K@1224|Proteobacteria,2U7BW@28211|Alphaproteobacteria,2PEUA@252301|Oceanicola	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS3_k127_8267817_1	237727.NAP1_12658	3.039e-118	385.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2K0BH@204457|Sphingomonadales	204457|Sphingomonadales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_8267817_0	391613.RTM1035_11150	2.196e-178	572.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria,46Q6X@74030|Roseovarius	28211|Alphaproteobacteria	E	Metallopeptidase family M24	dddP	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016829,GO:0016846,GO:0042802,GO:0042803,GO:0046983,GO:0047869	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
TLS3_k127_8267817_4	414684.RC1_0284	2.349e-50	189.0	COG3609@1|root,COG3609@2|Bacteria,1RHNZ@1224|Proteobacteria,2U6ZI@28211|Alphaproteobacteria,2JWP1@204441|Rhodospirillales	204441|Rhodospirillales	K	copG family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8267817_7	1123024.AUII01000004_gene1471	6.711e-05	46.0	COG3509@1|root,COG3509@2|Bacteria,2GMTA@201174|Actinobacteria,4DZE7@85010|Pseudonocardiales	201174|Actinobacteria	Q	Esterase PHB depolymerase	phaZ1	-	3.1.1.72	ko:K05972	-	-	-	-	ko00000,ko01000	-	-	-	CBM_2,Esterase_phd,RicinB_lectin_2,Ricin_B_lectin
TLS3_k127_8268251_2	1569209.BBPH01000004_gene1644	6.321e-33	140.0	COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,2PURS@265|Paracoccus	28211|Alphaproteobacteria	S	DNA repair protein MmcB-like	MA20_23405	-	-	-	-	-	-	-	-	-	-	-	MmcB-like
TLS3_k127_8268251_1	1354722.JQLS01000008_gene2807	2.139e-118	402.0	28JTG@1|root,2Z9IR@2|Bacteria,1R0GC@1224|Proteobacteria,2TURR@28211|Alphaproteobacteria,46S34@74030|Roseovarius	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2793)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2793
TLS3_k127_8268251_0	1266998.ATUJ01000003_gene1783	1.224e-228	726.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,2PW20@265|Paracoccus	28211|Alphaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS3_k127_8275712_0	1449351.RISW2_09675	7.063e-291	923.0	COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,2TQVD@28211|Alphaproteobacteria,4KNC3@93682|Roseivivax	28211|Alphaproteobacteria	H	With CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner	cobN	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel
TLS3_k127_8275712_1	1188256.BASI01000002_gene3518	1.552e-160	513.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TQWN@28211|Alphaproteobacteria,3FCJ3@34008|Rhodovulum	28211|Alphaproteobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	cobW	-	-	ko:K02234	-	-	-	-	ko00000,ko00001	-	-	-	CobW_C,cobW
TLS3_k127_8275712_4	1449351.RISW2_09665	4.14e-45	170.0	COG5469@1|root,COG5469@2|Bacteria,1N7P8@1224|Proteobacteria,2UGPN@28211|Alphaproteobacteria,4KNYV@93682|Roseivivax	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1636)	MA20_14540	-	-	-	-	-	-	-	-	-	-	-	DUF1636
TLS3_k127_8275712_5	331869.BAL199_24434	3.424e-40	171.0	COG2370@1|root,COG2370@2|Bacteria,1Q63I@1224|Proteobacteria,2UB26@28211|Alphaproteobacteria,4BQNU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	HupE / UreJ protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
TLS3_k127_8275712_3	1446473.JHWH01000003_gene3367	7.486e-93	310.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,2TT92@28211|Alphaproteobacteria,2PVZK@265|Paracoccus	28211|Alphaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	cobO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Co_AT_N,CobA_CobO_BtuR
TLS3_k127_8275712_2	272943.RSP_0796	1.534e-117	383.0	COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2TRHI@28211|Alphaproteobacteria,1FBHD@1060|Rhodobacter	28211|Alphaproteobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
TLS3_k127_8281333_0	412597.AEPN01000006_gene1637	1.788e-184	586.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,2PU1N@265|Paracoccus	28211|Alphaproteobacteria	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
TLS3_k127_8281333_2	716928.AJQT01000105_gene2499	6.023e-38	147.0	COG2764@1|root,COG2764@2|Bacteria,1RIZB@1224|Proteobacteria,2UITN@28211|Alphaproteobacteria,4BK7W@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_8281333_1	1380386.JIAW01000027_gene7078	2.27e-50	188.0	COG2207@1|root,COG2207@2|Bacteria,2GK7C@201174|Actinobacteria,235V5@1762|Mycobacteriaceae	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_8286911_5	1449065.JMLL01000010_gene1626	8.834e-07	50.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,43J5S@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	VWA domain containing CoxE-like protein	MA20_01305	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_8286911_4	1294273.roselon_03366	3.795e-22	101.0	2DPYV@1|root,3340H@2|Bacteria,1NBP5@1224|Proteobacteria,2UF3M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8286911_3	69279.BG36_04815	1.106e-48	187.0	COG0586@1|root,COG0586@2|Bacteria,1Q68Z@1224|Proteobacteria,2UA40@28211|Alphaproteobacteria,43MFH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_8286911_2	1123501.KB902315_gene3413	1.421e-67	256.0	COG5316@1|root,COG5316@2|Bacteria,1NWFX@1224|Proteobacteria,2U10J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
TLS3_k127_8286911_1	266809.PM03_14500	1.466e-91	308.0	COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2UQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidase M48	-	-	-	ko:K07387	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M48
TLS3_k127_8286911_0	89187.ISM_15690	1.41e-96	325.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,46NW3@74030|Roseovarius	28211|Alphaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_829069_1	1123247.AUIJ01000004_gene1115	1.007e-107	357.0	COG0115@1|root,COG0115@2|Bacteria,1MX5D@1224|Proteobacteria,2TRVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS3_k127_829069_0	1121033.AUCF01000013_gene1676	1.792e-131	436.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2JPHC@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_829069_3	398525.KB900701_gene1112	2.655e-57	215.0	28ID8@1|root,2Z8FH@2|Bacteria,1R422@1224|Proteobacteria,2U4SY@28211|Alphaproteobacteria,3JXR3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_829069_2	1469613.JT55_06530	3.371e-101	334.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,3FCKA@34008|Rhodovulum	28211|Alphaproteobacteria	KL	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS3_k127_8293789_2	376733.IT41_00710	8.445e-16	79.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,2PVB3@265|Paracoccus	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS3_k127_8293789_0	1353528.DT23_10545	7.339e-176	555.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria,2XMPF@285107|Thioclava	28211|Alphaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS3_k127_8293789_1	314265.R2601_12810	3.698e-31	123.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_8307969_7	1479237.JMLY01000001_gene2553	0.0001436	51.0	2DNJ3@1|root,32XS3@2|Bacteria,1N5GA@1224|Proteobacteria,1S9KP@1236|Gammaproteobacteria,46C2I@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
TLS3_k127_8307969_0	935565.JAEM01000003_gene3377	0.0	1262.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2PUUF@265|Paracoccus	28211|Alphaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS3_k127_8307969_6	317655.Sala_2318	3.423e-18	91.0	COG4391@1|root,COG4391@2|Bacteria,1N7F4@1224|Proteobacteria,2UHY4@28211|Alphaproteobacteria,2K6U4@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
TLS3_k127_8307969_1	1530186.JQEY01000004_gene1955	7.444e-127	414.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	yadG	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_8307969_3	1294273.roselon_02464	8.499e-50	190.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria	28211|Alphaproteobacteria	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	pkcI	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS3_k127_8307969_5	398580.Dshi_3446	2.063e-38	149.0	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein affecting phage T7 exclusion by the F plasmid	fxsA	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TLS3_k127_8307969_2	571166.KI421509_gene2657	5.908e-75	271.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	import inner membrane translocase, subunit Tim44	MA20_24770	-	-	-	-	-	-	-	-	-	-	-	Tim44
TLS3_k127_8307969_4	1231392.OCGS_1519	1.254e-41	160.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Smr protein MutS2	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
TLS3_k127_833362_5	349102.Rsph17025_1859	3.374e-20	96.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TS06@28211|Alphaproteobacteria,1FCGZ@1060|Rhodobacter	28211|Alphaproteobacteria	H	PFAM Aminotransferase class I and II	aspB	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS3_k127_833362_1	266809.PM03_05540	4.804e-96	331.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase M48	MA20_29180	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16,TPR_19
TLS3_k127_833362_3	501479.ACNW01000086_gene3901	1.155e-65	232.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Dsba oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
TLS3_k127_833362_4	501479.ACNW01000057_gene4299	3.275e-54	196.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS3_k127_833362_0	1188256.BASI01000002_gene3100	5.913e-236	737.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,3FCRI@34008|Rhodovulum	28211|Alphaproteobacteria	I	Biotin carboxylase C-terminal domain	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
TLS3_k127_833362_2	1123247.AUIJ01000002_gene2327	3.793e-77	266.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TLS3_k127_8336271_2	1461694.ATO9_05205	6.963e-08	55.0	2AJD5@1|root,319YN@2|Bacteria,1Q4GF@1224|Proteobacteria,2VAYM@28211|Alphaproteobacteria,2PEVZ@252301|Oceanicola	28211|Alphaproteobacteria	S	Bacterial aa3 type cytochrome c oxidase subunit IV	-	-	-	-	-	-	-	-	-	-	-	-	COX4_pro_2
TLS3_k127_8336271_0	349102.Rsph17025_2462	4.963e-223	704.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,1FBH2@1060|Rhodobacter	28211|Alphaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS3_k127_8336271_1	1342299.Z947_3841	2.207e-60	236.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria,3ZWR7@60136|Sulfitobacter	28211|Alphaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
TLS3_k127_8358488_5	1317118.ATO8_14462	0.0002758	45.0	COG0500@1|root,COG2226@2|Bacteria,1RAAZ@1224|Proteobacteria,2U5A9@28211|Alphaproteobacteria,4KMZI@93682|Roseivivax	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_8358488_4	379066.GAU_3413	1.477e-69	244.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_8358488_0	1417296.U879_18105	1.761e-184	599.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
TLS3_k127_8358488_1	1530186.JQEY01000002_gene1606	9.905e-184	587.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS3_k127_8358488_2	1188256.BASI01000005_gene1850	6.163e-160	522.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,3FCTJ@34008|Rhodovulum	28211|Alphaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01928,ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_8358488_3	1469613.JT55_02550	3.297e-98	325.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,3FCJA@34008|Rhodovulum	28211|Alphaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_835918_2	762376.AXYL_03599	8.492e-41	157.0	COG2207@1|root,COG2207@2|Bacteria,1RBR5@1224|Proteobacteria	1224|Proteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
TLS3_k127_835918_4	187272.Mlg_2100	7.711e-16	79.0	2DEYJ@1|root,2ZPSQ@2|Bacteria,1P45K@1224|Proteobacteria,1STHP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_835918_3	1317118.ATO8_15042	1.769e-38	161.0	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,2U93G@28211|Alphaproteobacteria,4KMR1@93682|Roseivivax	28211|Alphaproteobacteria	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
TLS3_k127_835918_1	1231392.OCGS_1241	7.497e-61	228.0	COG3713@1|root,COG3713@2|Bacteria,1REKJ@1224|Proteobacteria,2U37S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG3713 Outer membrane protein V	-	-	-	ko:K07274	-	-	-	-	ko00000,ko02000	9.B.99.1	-	-	MipA
TLS3_k127_835918_0	1220582.RRU01S_14_01180	0.0	1106.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,4BB0S@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
TLS3_k127_8368440_0	1211115.ALIQ01000219_gene1410	1.712e-110	368.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2U1G2@28211|Alphaproteobacteria,3NABB@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
TLS3_k127_8368440_2	314256.OG2516_14486	7.931e-21	100.0	COG1434@1|root,COG1434@2|Bacteria,1NDJM@1224|Proteobacteria,2UCMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
TLS3_k127_8368440_3	221288.JH992901_gene2536	7.848e-15	87.0	28MNK@1|root,2ZAY4@2|Bacteria	2|Bacteria	-	-	-	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
TLS3_k127_8368440_1	221288.JH992901_gene2537	1.429e-48	184.0	COG2304@1|root,COG2304@2|Bacteria,1GBBJ@1117|Cyanobacteria	2|Bacteria	S	PFAM Common central domain of tyrosinase	-	-	1.14.18.1	ko:K00505,ko:K02674	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	-	-	-	Neisseria_PilC,Tyrosinase,VWA_2
TLS3_k127_839313_0	398580.Dshi_1759	3.979e-162	516.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS3_k127_839313_4	1211115.ALIQ01000013_gene2300	3.391e-36	157.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TTN5@28211|Alphaproteobacteria,3NADJ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Virulence factor BrkB	MA20_20550	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS3_k127_839313_2	1123072.AUDH01000001_gene3066	3.107e-46	180.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,2JSN0@204441|Rhodospirillales	204441|Rhodospirillales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
TLS3_k127_839313_1	935840.JAEQ01000006_gene2471	4.882e-64	227.0	COG1335@1|root,COG1335@2|Bacteria,1NZJ1@1224|Proteobacteria,2VG5U@28211|Alphaproteobacteria,43RNF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS3_k127_839313_3	1121479.AUBS01000001_gene3282	3.941e-39	154.0	COG1569@1|root,COG1569@2|Bacteria,1RCZE@1224|Proteobacteria,2U5DQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
TLS3_k127_839313_5	314271.RB2654_03499	1.599e-12	67.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2TUNR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	SAM-dependent	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
TLS3_k127_8404979_3	1417296.U879_07765	2.595e-27	113.0	COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,2U851@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS3_k127_8404979_0	1188256.BASI01000001_gene281	2.805e-55	203.0	COG1670@1|root,COG1670@2|Bacteria,1PY0X@1224|Proteobacteria,2U6A8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_8404979_1	272943.RSP_1050	2.429e-54	207.0	COG1670@1|root,COG1670@2|Bacteria,1PY0X@1224|Proteobacteria,2U9QD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
TLS3_k127_8404979_2	1525715.IX54_11575	2.928e-39	151.0	COG1605@1|root,COG1605@2|Bacteria,1MZTQ@1224|Proteobacteria,2UCMC@28211|Alphaproteobacteria,2PXE2@265|Paracoccus	28211|Alphaproteobacteria	E	Chorismate mutase type II	tyrA	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
TLS3_k127_8424164_5	398580.Dshi_2489	3.428e-68	236.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS3_k127_8424164_1	1294273.roselon_02260	9.785e-167	533.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TLS3_k127_8424164_0	1294273.roselon_02261	1.329e-191	604.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	mtkA	-	6.2.1.5,6.2.1.9	ko:K01903,ko:K14067	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS3_k127_8424164_2	1449350.OCH239_04020	4.141e-156	497.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TTC8@28211|Alphaproteobacteria,4KKA1@93682|Roseivivax	28211|Alphaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	mtkB	-	6.2.1.5,6.2.1.9	ko:K01902,ko:K08692	ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00346,M00374,M00620	R00405,R01256,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS3_k127_8424164_4	252305.OB2597_07415	1.456e-85	294.0	COG2514@1|root,COG2514@2|Bacteria,1RBC7@1224|Proteobacteria,2U5JP@28211|Alphaproteobacteria,2PE1E@252301|Oceanicola	28211|Alphaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_22790	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS3_k127_8424164_3	34007.IT40_18950	2.482e-92	315.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,2PVYD@265|Paracoccus	28211|Alphaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	tRNA_U5-meth_tr
TLS3_k127_8436151_0	1231392.OCGS_0961	0.0	1118.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS3_k127_8436151_3	1118153.MOY_10485	1.143e-71	256.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1S79G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport,GAF
TLS3_k127_8436151_2	794846.AJQU01000093_gene2364	1.037e-108	358.0	COG0823@1|root,COG0823@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria,4B8F5@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Periplasmic component of the Tol biopolymer transport system	tolB2	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
TLS3_k127_8436151_1	318586.Pden_0061	3.263e-127	411.0	28M6T@1|root,2ZAKD@2|Bacteria,1MXS6@1224|Proteobacteria,2TV0T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8436151_4	1469613.JT55_16875	6.643e-57	218.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,3FD32@34008|Rhodovulum	28211|Alphaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS3_k127_8438456_1	452662.SJA_C1-06600	3.659e-93	327.0	COG0784@1|root,COG4191@1|root,COG5278@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5278@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,Response_reg
TLS3_k127_8438456_0	1525715.IX54_12705	1.567e-117	386.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,2PU17@265|Paracoccus	28211|Alphaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS3_k127_8438456_2	1122218.KB893653_gene823	0.000141	54.0	COG3064@1|root,COG3064@2|Bacteria,1NAWA@1224|Proteobacteria,2TSQY@28211|Alphaproteobacteria,1JSUV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
TLS3_k127_8443695_4	1122214.AQWH01000001_gene790	1.979e-71	248.0	COG2188@1|root,COG2188@2|Bacteria,1P6ZJ@1224|Proteobacteria,2U1UP@28211|Alphaproteobacteria,2PMFQ@255475|Aurantimonadaceae	28211|Alphaproteobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS3_k127_8443695_6	1144310.PMI07_005150	1.541e-65	238.0	COG1940@1|root,COG3010@1|root,COG1940@2|Bacteria,COG3010@2|Bacteria,1PRVW@1224|Proteobacteria,2U5HD@28211|Alphaproteobacteria,4B8K0@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Putative N-acetylmannosamine-6-phosphate epimerase	nanE	-	2.7.1.60,5.1.3.9	ko:K13967	ko00520,ko01100,map00520,map01100	-	R02087,R02705	RC00002,RC00017,RC00290	ko00000,ko00001,ko01000	-	-	-	NanE,ROK
TLS3_k127_8443695_5	1320556.AVBP01000022_gene1958	1.186e-65	244.0	COG1940@1|root,COG1940@2|Bacteria,1Q78E@1224|Proteobacteria,2VGK8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	ROK family	-	-	2.7.1.60,5.1.3.9	ko:K13967	ko00520,ko01100,map00520,map01100	-	R02087,R02705	RC00002,RC00017,RC00290	ko00000,ko00001,ko01000	-	-	-	ROK
TLS3_k127_8443695_0	1231185.BAMP01000084_gene3604	2.167e-202	638.0	COG1653@1|root,COG1653@2|Bacteria,1P9CK@1224|Proteobacteria,2U1E3@28211|Alphaproteobacteria,43R4Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_8443695_2	935840.JAEQ01000008_gene738	5.462e-114	376.0	COG1175@1|root,COG1175@2|Bacteria,1N9Y4@1224|Proteobacteria,2U1XI@28211|Alphaproteobacteria,43NBS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_8443695_3	1320556.AVBP01000022_gene1955	1.208e-102	351.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TQJF@28211|Alphaproteobacteria,43N23@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_8443695_1	1123360.thalar_00565	8.993e-163	518.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC-type multidrug transport system ATPase and permease	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_845168_3	1469613.JT55_01125	5.246e-21	106.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,3FCKT@34008|Rhodovulum	28211|Alphaproteobacteria	L	PD-(D/E)XK nuclease superfamily	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
TLS3_k127_845168_2	1449351.RISW2_10605	7.328e-69	246.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,4KKK6@93682|Roseivivax	28211|Alphaproteobacteria	JM	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	MA20_24100	-	2.7.7.13,2.7.7.99	ko:K00966,ko:K00992	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885,R11025	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
TLS3_k127_845168_1	1188256.BASI01000001_gene846	2.913e-84	294.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,3FD30@34008|Rhodovulum	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	MA20_24090	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,TsaE
TLS3_k127_845168_4	1469613.JT55_09825	4.758e-20	103.0	2E3KZ@1|root,32YJ8@2|Bacteria,1N7A7@1224|Proteobacteria,2UFMR@28211|Alphaproteobacteria,3FDGD@34008|Rhodovulum	28211|Alphaproteobacteria	S	Putative prokaryotic signal transducing protein	MA20_42240	-	-	-	-	-	-	-	-	-	-	-	DUF2007
TLS3_k127_845168_0	999547.KI421500_gene2043	1.759e-143	469.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,280VF@191028|Leisingera	28211|Alphaproteobacteria	H	Polyprenyl synthetase	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS3_k127_8473801_3	1294273.roselon_03143	1.386e-85	300.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS3_k127_8473801_4	1121943.KB899999_gene1451	3.996e-54	218.0	COG1414@1|root,COG1414@2|Bacteria,1RC3A@1224|Proteobacteria,1S52U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
TLS3_k127_8473801_0	1238182.C882_2271	5.293e-320	996.0	COG1018@1|root,COG2124@1|root,COG1018@2|Bacteria,COG2124@2|Bacteria,1MU6E@1224|Proteobacteria,2TRE9@28211|Alphaproteobacteria,2JSS9@204441|Rhodospirillales	204441|Rhodospirillales	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TLS3_k127_8473801_2	766499.C357_15886	5.105e-150	481.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TQVT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
TLS3_k127_8473801_5	1121479.AUBS01000041_gene649	1.16e-39	152.0	COG3090@1|root,COG3090@2|Bacteria,1NCZ4@1224|Proteobacteria,2UF1J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
TLS3_k127_8473801_1	1121479.AUBS01000041_gene648	1.773e-177	574.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
TLS3_k127_8473801_6	314256.OG2516_03003	1.764e-05	55.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2U74H@28211|Alphaproteobacteria,2PCZH@252301|Oceanicola	28211|Alphaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS3_k127_8475933_12	290398.Csal_1191	2.57e-19	89.0	COG2197@1|root,COG2197@2|Bacteria,1RDI0@1224|Proteobacteria,1S0JJ@1236|Gammaproteobacteria,1XS3K@135619|Oceanospirillales	135619|Oceanospirillales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS3_k127_8475933_8	266835.14024284	3.426e-101	337.0	COG1028@1|root,COG1028@2|Bacteria,1R756@1224|Proteobacteria,2U232@28211|Alphaproteobacteria,43MTU@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_8475933_11	1342302.JASC01000014_gene782	1.196e-49	193.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2U8KY@28211|Alphaproteobacteria,3ZV17@60136|Sulfitobacter	28211|Alphaproteobacteria	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS3_k127_8475933_9	34007.IT40_23140	1.236e-74	269.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2U5II@28211|Alphaproteobacteria,2PW0V@265|Paracoccus	28211|Alphaproteobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TLS3_k127_8475933_1	1530186.JQEY01000017_gene223	3.147e-248	778.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Iron-sulfur cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
TLS3_k127_8475933_5	1530186.JQEY01000017_gene224	1.306e-125	406.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	glycolate oxidase iron-sulfur subunit	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS3_k127_8475933_0	1530186.JQEY01000017_gene225	1.881e-295	915.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,2TQY1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
TLS3_k127_8475933_7	1399774.JDWH01000001_gene2741	4.435e-113	383.0	COG3934@1|root,COG3934@2|Bacteria,1R46J@1224|Proteobacteria,1RPDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
TLS3_k127_8475933_3	1439940.BAY1663_04658	1.151e-140	459.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,1RPHZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	beta-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
TLS3_k127_8475933_6	1121106.JQKB01000019_gene2899	9.362e-124	408.0	COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,2U23S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
TLS3_k127_8475933_2	935840.JAEQ01000009_gene1338	4.03e-189	605.0	COG0562@1|root,COG0562@2|Bacteria,1MV4H@1224|Proteobacteria,2TTP4@28211|Alphaproteobacteria,43NHY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,Glyco_trans_1_4,NAD_binding_8
TLS3_k127_8475933_4	1304883.KI912532_gene1230	1.683e-131	432.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,2KUVW@206389|Rhodocyclales	206389|Rhodocyclales	M	UDP-glucose 4-epimerase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
TLS3_k127_8475933_13	935848.JAEN01000008_gene683	5.061e-05	52.0	COG2823@1|root,COG2823@2|Bacteria,1PGZZ@1224|Proteobacteria,2V1ZX@28211|Alphaproteobacteria,2PZ0A@265|Paracoccus	28211|Alphaproteobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8475933_10	1336235.JAEG01000008_gene1153	1.8e-74	253.0	COG3685@1|root,COG3685@2|Bacteria,1REKN@1224|Proteobacteria,2U73U@28211|Alphaproteobacteria,4B9P3@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
TLS3_k127_8525016_2	1123269.NX02_17550	5.323e-06	51.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K5QE@204457|Sphingomonadales	204457|Sphingomonadales	Q	Peptidase M10 serralysin C terminal	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,PPC,Peptidase_M10_C,Reprolysin_4
TLS3_k127_8525016_0	1089552.KI911559_gene3332	1.378e-93	325.0	COG3243@1|root,COG3243@2|Bacteria,1Q6YK@1224|Proteobacteria,2TTVK@28211|Alphaproteobacteria,2JQPE@204441|Rhodospirillales	204441|Rhodospirillales	I	alpha/beta hydrolase fold	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
TLS3_k127_8525016_1	402881.Plav_1572	5.413e-52	194.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,1JNVK@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	PHB accumulation regulatory domain	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
TLS3_k127_8547774_2	376733.IT41_12370	9.206e-160	509.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TV27@28211|Alphaproteobacteria,2PWBW@265|Paracoccus	28211|Alphaproteobacteria	G	Periplasmic binding protein-like domain	-	-	-	ko:K17202	ko02010,map02010	M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.11,3.A.1.2.16	-	-	Peripla_BP_4
TLS3_k127_8547774_0	1082933.MEA186_25969	4.768e-219	691.0	COG1070@1|root,COG1070@2|Bacteria,1MWS5@1224|Proteobacteria,2TUKK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the FGGY kinase family	-	-	2.7.1.53	ko:K00880	ko00040,ko00053,map00040,map00053	-	R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_8547774_1	1101189.AQUO01000002_gene673	5.027e-189	625.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TQV2@28211|Alphaproteobacteria,2PY48@265|Paracoccus	28211|Alphaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS3_k127_8551033_1	1417296.U879_12530	5.058e-66	231.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
TLS3_k127_8551033_0	1125973.JNLC01000017_gene3588	1.753e-207	652.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,3JQMG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS3_k127_879537_3	187303.BN69_2478	1.871e-40	156.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2TQRV@28211|Alphaproteobacteria,36Y60@31993|Methylocystaceae	28211|Alphaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
TLS3_k127_879537_1	1144343.PMI41_03118	3.939e-106	359.0	COG3822@1|root,COG3822@2|Bacteria,1MWPT@1224|Proteobacteria,2U2MB@28211|Alphaproteobacteria,43H7R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ABC-type sugar transport system, auxiliary component	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
TLS3_k127_879537_0	1336249.JADW01000005_gene2307	3.059e-207	653.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,4B7QK@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	glutamine synthetase	glnA2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS3_k127_879537_2	314264.ROS217_17447	3.669e-46	175.0	COG3932@1|root,COG3932@2|Bacteria,1MZD5@1224|Proteobacteria,2U77X@28211|Alphaproteobacteria,46QQ2@74030|Roseovarius	28211|Alphaproteobacteria	S	Exopolysaccharide synthesis, ExoD	-	-	-	-	-	-	-	-	-	-	-	-	ExoD
TLS3_k127_880198_3	1121033.AUCF01000001_gene1942	4.396e-95	317.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,2JQ28@204441|Rhodospirillales	204441|Rhodospirillales	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
TLS3_k127_880198_2	1370122.JHXQ01000008_gene1882	9.216e-103	346.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2TSR9@28211|Alphaproteobacteria,4B7NF@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ornithine cyclodeaminase	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS3_k127_880198_0	1123501.KB902313_gene2831	2.141e-149	482.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2TS9C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Aminotransferase	tyrB	-	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_880198_4	1294273.roselon_01252	8.499e-55	201.0	COG0454@1|root,COG0454@2|Bacteria,1RDGT@1224|Proteobacteria,2TRF5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
TLS3_k127_880198_1	1449351.RISW2_12380	8.313e-134	433.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,4KKDA@93682|Roseivivax	28211|Alphaproteobacteria	H	Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS3_k127_88959_1	1038858.AXBA01000017_gene1128	1.681e-105	358.0	COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2TRBE@28211|Alphaproteobacteria,3EY42@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Mannitol dehydrogenase Rossmann domain	uxuB	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
TLS3_k127_88959_4	1472418.BBJC01000006_gene2446	5.775e-63	220.0	COG0251@1|root,COG0251@2|Bacteria,1RG2H@1224|Proteobacteria	1224|Proteobacteria	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
TLS3_k127_88959_3	1472418.BBJC01000006_gene2445	3.206e-72	248.0	COG2249@1|root,COG2249@2|Bacteria,1MUHN@1224|Proteobacteria,2U9KV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NADPH-quinone reductase (modulator of drug activity B)	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
TLS3_k127_88959_0	1472418.BBJC01000006_gene2444	7.151e-139	453.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2TTW8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter substrate-binding protein	MA20_40330	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS3_k127_88959_2	1410620.SHLA_2c000220	1.4e-86	289.0	COG0277@1|root,COG0277@2|Bacteria,1MUKV@1224|Proteobacteria,2TVCQ@28211|Alphaproteobacteria,4BA4S@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
TLS3_k127_895084_0	314256.OG2516_17071	3.055e-158	518.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2PD31@252301|Oceanicola	28211|Alphaproteobacteria	L	Helicase associated domain (HA2)  Add an annotation	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
TLS3_k127_895084_4	398580.Dshi_2581	6.031e-31	136.0	29M59@1|root,3082Q@2|Bacteria,1PUXY@1224|Proteobacteria,2U6M4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
TLS3_k127_895084_2	1525715.IX54_12705	2.032e-108	362.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,2PU17@265|Paracoccus	28211|Alphaproteobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS3_k127_895084_3	398580.Dshi_2583	1.638e-41	155.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS3_k127_895084_5	1288494.EBAPG3_30870	1.246e-25	118.0	COG2304@1|root,COG2304@2|Bacteria,1PXCB@1224|Proteobacteria,2WCTS@28216|Betaproteobacteria,374DH@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Common central domain of tyrosinase	-	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
TLS3_k127_895084_1	398580.Dshi_1375	7.416e-153	494.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speF	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS3_k127_898973_2	501479.ACNW01000097_gene1058	4.99e-111	370.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPase, AFG1 family	zapE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
TLS3_k127_898973_0	511062.GU3_08825	4.797e-144	468.0	COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1Y5RN@135624|Aeromonadales	135624|Aeromonadales	M	Transglycosylase SLT domain	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	PG_binding_1,SLT_2
TLS3_k127_898973_3	1122218.KB893653_gene466	1.981e-58	216.0	COG3153@1|root,COG3153@2|Bacteria,1RD0C@1224|Proteobacteria,2U7AS@28211|Alphaproteobacteria,1JUVN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	MA20_06530	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9
TLS3_k127_898973_1	536019.Mesop_4954	1.061e-133	435.0	COG1609@1|root,COG1609@2|Bacteria,1N2TE@1224|Proteobacteria,2TV4Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS3_k127_906066_1	571166.KI421509_gene3293	2.586e-56	204.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
TLS3_k127_906066_0	1244869.H261_06209	5.632e-236	740.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,2JP99@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_910160_5	501479.ACNW01000103_gene651	2.68e-61	217.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS3_k127_910160_2	1188256.BASI01000002_gene3267	2.827e-129	432.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2TSYY@28211|Alphaproteobacteria,3FDT4@34008|Rhodovulum	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_910160_6	1415756.JQMY01000001_gene1348	0.0008692	46.0	2AJD5@1|root,319YN@2|Bacteria,1Q4GF@1224|Proteobacteria,2VAYM@28211|Alphaproteobacteria,2PEVZ@252301|Oceanicola	28211|Alphaproteobacteria	S	Bacterial aa3 type cytochrome c oxidase subunit IV	-	-	-	-	-	-	-	-	-	-	-	-	COX4_pro_2
TLS3_k127_910160_3	1089551.KE386572_gene65	2.176e-99	330.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,4BSGF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_910160_4	288000.BBta_0454	2.699e-87	308.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,3JR4Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS3_k127_910160_1	460265.Mnod_6709	6.147e-133	429.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,1JTBT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	NADP oxidoreductase coenzyme F420-dependent	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
TLS3_k127_910160_0	195105.CN97_01025	4.539e-133	437.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG2366 Protein related to penicillin acylase	quiP	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS3_k127_913655_1	1449351.RISW2_10180	7.776e-118	391.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,4KM1Z@93682|Roseivivax	28211|Alphaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_913655_2	506534.Rhein_1451	3.82e-07	58.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1SE25@1236|Gammaproteobacteria,1WZBZ@135613|Chromatiales	135613|Chromatiales	S	BLUF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
TLS3_k127_913655_3	281090.Lxx04275	4.082e-06	56.0	COG3431@1|root,COG3431@2|Bacteria,2GQM3@201174|Actinobacteria,4FQ4X@85023|Microbacteriaceae	201174|Actinobacteria	S	of blue-light using FAD. The BLUF domain has been shown to bind FAD in the AppA protein	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
TLS3_k127_913655_0	314256.OG2516_08331	1.567e-169	539.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2PCKT@252301|Oceanicola	28211|Alphaproteobacteria	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS3_k127_921553_8	1502851.FG93_04628	1.543e-43	166.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,3JSB3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
TLS3_k127_921553_4	1453501.JELR01000001_gene3162	1.947e-233	730.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
TLS3_k127_921553_5	1523503.JPMY01000016_gene727	1.184e-197	646.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
TLS3_k127_921553_6	765911.Thivi_1389	6.175e-76	262.0	COG3637@1|root,COG3637@2|Bacteria,1QYQM@1224|Proteobacteria,1T59D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_921553_1	1366046.HIMB11_00962	1.293e-316	974.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,3ZG0V@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
TLS3_k127_921553_10	371731.Rsw2DRAFT_1449	2.28e-33	134.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,1FBZ8@1060|Rhodobacter	28211|Alphaproteobacteria	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS3_k127_921553_3	1417296.U879_08220	8.862e-288	895.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_921553_11	269796.Rru_A0391	2.281e-06	53.0	2ECMA@1|root,336JB@2|Bacteria,1N75G@1224|Proteobacteria,2UI2I@28211|Alphaproteobacteria,2JTZD@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_921553_7	1123247.AUIJ01000001_gene1643	2.434e-50	183.0	2AFS6@1|root,315U5@2|Bacteria,1RHM3@1224|Proteobacteria,2U9EY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_921553_2	349102.Rsph17025_2302	1.609e-303	946.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,1FAUN@1060|Rhodobacter	28211|Alphaproteobacteria	I	Carbamoyl-phosphate synthase L chain	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS3_k127_921553_9	1123237.Salmuc_01123	1.483e-34	139.0	2CH3G@1|root,32S56@2|Bacteria,1N1AC@1224|Proteobacteria,2UCDP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4174)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4174
TLS3_k127_921553_0	1123501.KB902310_gene60	0.0	1159.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	bhbA	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS3_k127_924204_1	1188256.BASI01000002_gene3578	6.068e-79	272.0	COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria,3FD5I@34008|Rhodovulum	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
TLS3_k127_924204_6	314265.R2601_22462	6.625e-17	91.0	2E5JU@1|root,330B2@2|Bacteria,1N77B@1224|Proteobacteria,2UH27@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3553)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3553
TLS3_k127_924204_4	1185766.DL1_00105	2.261e-35	148.0	COG5385@1|root,COG5385@2|Bacteria,1MVEY@1224|Proteobacteria,2TSE6@28211|Alphaproteobacteria,2XNAK@285107|Thioclava	28211|Alphaproteobacteria	S	Histidine phosphotransferase C-terminal domain	MA20_46320	-	-	ko:K13588	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001	-	-	-	HPTransfase
TLS3_k127_924204_3	1188256.BASI01000003_gene2647	2.046e-63	226.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,3FD36@34008|Rhodovulum	28211|Alphaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	dapH	-	-	-	-	-	-	-	-	-	-	-	Hexapep
TLS3_k127_924204_0	266809.PM03_10360	4.754e-92	307.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS3_k127_924204_2	1121271.AUCM01000003_gene1393	2.14e-72	255.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2TS81@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Stress-induced protein	yicC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
TLS3_k127_924204_5	1300350.DSW25_15715	2.333e-34	140.0	COG5388@1|root,COG5388@2|Bacteria,1RCVG@1224|Proteobacteria,2U2IX@28211|Alphaproteobacteria,3ZX31@60136|Sulfitobacter	28211|Alphaproteobacteria	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_5
TLS3_k127_933738_0	1123360.thalar_03160	4.809e-246	771.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
TLS3_k127_933738_1	398580.Dshi_1819	3.048e-56	205.0	COG2197@1|root,COG2197@2|Bacteria,1RFWB@1224|Proteobacteria,2U8BA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG2771 DNA-binding HTH domain-containing proteins	-	-	-	ko:K07782,ko:K19731	ko02020,ko02024,ko02026,map02020,map02024,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
TLS3_k127_937668_3	349102.Rsph17025_1874	3.288e-13	76.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,1FAQC@1060|Rhodobacter	28211|Alphaproteobacteria	C	TIGRFAM sarcosine oxidase, alpha subunit family	soxA	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
TLS3_k127_937668_1	1353528.DT23_00970	1.986e-50	181.0	COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria,2XNJ6@285107|Thioclava	28211|Alphaproteobacteria	E	Sarcosine oxidase subunit delta	soxD	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
TLS3_k127_937668_0	1122614.JHZF01000016_gene498	4.279e-211	663.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,2PDPC@252301|Oceanicola	28211|Alphaproteobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	soxB3	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
TLS3_k127_937668_2	349102.Rsph17025_1878	4.152e-50	190.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,1FBEK@1060|Rhodobacter	28211|Alphaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_19
TLS3_k127_959123_1	252305.OB2597_02457	1.643e-239	754.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,2PD23@252301|Oceanicola	28211|Alphaproteobacteria	S	ABC transporter C-terminal domain	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
TLS3_k127_959123_0	504472.Slin_6268	0.0	1118.0	COG0369@1|root,COG1017@1|root,COG4362@1|root,COG0369@2|Bacteria,COG1017@2|Bacteria,COG4362@2|Bacteria,4NHR8@976|Bacteroidetes,47QP9@768503|Cytophagia	976|Bacteroidetes	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component	cysJ	-	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
TLS3_k127_959123_2	228405.HNE_2434	3.369e-22	101.0	COG1060@1|root,COG1060@2|Bacteria,1N4ZG@1224|Proteobacteria,2UEFX@28211|Alphaproteobacteria,440BD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Haem-NO-binding	-	-	-	-	-	-	-	-	-	-	-	-	HNOB
## 3105 queries scanned
## Total time (seconds): 30.81118631362915
## Rate: 100.78 q/s