## Sat Nov 16 01:25:38 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin28/TLS_3_bin.9.fa -m mmseqs --itype genome -o TLS_3_bin.9 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/TLS_3_bin.9 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
TLS3_k127_1044576_5	1123023.JIAI01000001_gene7200	6.429e-141	448.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
TLS3_k127_1044576_1	1108045.GORHZ_118_00140	1.83e-254	812.0	COG0437@1|root,COG3301@1|root,COG0437@2|Bacteria,COG3301@2|Bacteria,2I2DV@201174|Actinobacteria	201174|Actinobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_7,NrfD
TLS3_k127_1044576_3	1123024.AUII01000032_gene3794	4.286e-182	577.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4E527@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	fccB	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS3_k127_1044576_2	2074.JNYD01000002_gene5574	2.388e-209	669.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4E0XN@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS3_k127_1044576_6	1120948.KB903247_gene4581	1.606e-100	333.0	COG2188@1|root,COG2188@2|Bacteria,2GKMH@201174|Actinobacteria,4E1DD@85010|Pseudonocardiales	201174|Actinobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS3_k127_1044576_4	1089544.KB912942_gene1879	8.38e-149	500.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DYHG@85010|Pseudonocardiales	201174|Actinobacteria	M	enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS3_k127_1044576_7	710111.FraQA3DRAFT_3904	4.375e-96	340.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4ESBZ@85013|Frankiales	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS3_k127_1044576_0	1206730.BAGA01000079_gene1216	0.0	1072.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,2I2RH@201174|Actinobacteria,4G8NE@85025|Nocardiaceae	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
TLS3_k127_1044576_10	1299327.I546_0679	1.082e-10	72.0	COG1544@1|root,COG1544@2|Bacteria,2IB6N@201174|Actinobacteria,236GW@1762|Mycobacteriaceae	201174|Actinobacteria	J	Ribosome-associated protein Y (PSrp-1)	-	-	-	-	-	-	-	-	-	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS3_k127_1044576_9	164757.Mjls_1123	2.817e-21	98.0	COG1544@1|root,COG1544@2|Bacteria,2IB6N@201174|Actinobacteria,236GW@1762|Mycobacteriaceae	201174|Actinobacteria	J	Ribosome-associated protein Y (PSrp-1)	-	-	-	-	-	-	-	-	-	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS3_k127_1044576_8	1125971.ASJB01000099_gene2289	1.691e-54	196.0	COG1544@1|root,COG1544@2|Bacteria,2IB6N@201174|Actinobacteria,4E3BW@85010|Pseudonocardiales	201174|Actinobacteria	J	Sigma 54 modulation/S30EA ribosomal protein C terminus	-	-	-	-	-	-	-	-	-	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
TLS3_k127_1049480_27	1193181.BN10_810021	3.531e-12	72.0	2ASDR@1|root,31HT7@2|Bacteria,2GZEA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1049480_12	1385519.N801_09615	1.525e-143	464.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4FFN0@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS3_k127_1049480_14	1385520.N802_14660	8.658e-132	426.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4FFBT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
TLS3_k127_1049480_25	1122609.AUGT01000009_gene3184	2.465e-36	156.0	COG1985@1|root,COG1985@2|Bacteria,2GN2P@201174|Actinobacteria,4DRKD@85009|Propionibacteriales	201174|Actinobacteria	H	RibD C-terminal domain	ribD	-	1.1.1.193	ko:K00082	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R03458	RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
TLS3_k127_1049480_15	313589.JNB_02050	2.373e-131	434.0	COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4FES9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS3_k127_1049480_0	367299.JOEE01000008_gene454	0.0	1145.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4FEP0@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA ligase	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
TLS3_k127_1049480_18	935866.JAER01000002_gene1836	6.732e-90	300.0	COG1881@1|root,COG1881@2|Bacteria,2GMIG@201174|Actinobacteria,4DQA1@85009|Propionibacteriales	201174|Actinobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
TLS3_k127_1049480_20	1193181.BN10_810014	4.259e-80	269.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4FGN2@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
TLS3_k127_1049480_19	1385519.N801_19835	5.234e-82	283.0	COG5340@1|root,COG5340@2|Bacteria,2IMGD@201174|Actinobacteria,4FH66@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS3_k127_1049480_16	1385521.N803_07400	6.426e-129	418.0	COG3253@1|root,COG3253@2|Bacteria,2GK24@201174|Actinobacteria,4FE6U@85021|Intrasporangiaceae	201174|Actinobacteria	S	Chlorite dismutase	cld	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
TLS3_k127_1049480_13	367299.JOEE01000008_gene450	1.133e-139	458.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4FEAF@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
TLS3_k127_1049480_23	1385518.N798_04955	1.789e-39	166.0	COG1579@1|root,COG1579@2|Bacteria,2I2XU@201174|Actinobacteria,4FJYK@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
TLS3_k127_1049480_8	710696.Intca_1910	1.212e-178	567.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,4FFFP@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
TLS3_k127_1049480_21	188626.HMPREF0321_0149	1.508e-66	235.0	2AIF4@1|root,318WM@2|Bacteria,2GK8R@201174|Actinobacteria,1ZW4U@145357|Dermacoccaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3000)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3000
TLS3_k127_1049480_6	1385518.N798_04935	9.312e-185	591.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4FEWV@85021|Intrasporangiaceae	201174|Actinobacteria	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
TLS3_k127_1049480_4	1385518.N798_04930	4.682e-225	703.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FER0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_1049480_1	1193181.BN10_810004	0.0	1060.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria,4FF41@85021|Intrasporangiaceae	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS3_k127_1049480_3	1386089.N865_12730	4.39e-280	866.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4FEVM@85021|Intrasporangiaceae	201174|Actinobacteria	M	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
TLS3_k127_1049480_2	1193181.BN10_810002	4.501e-317	989.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4FEE6@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
TLS3_k127_1049480_26	1121017.AUFG01000001_gene3049	1.739e-33	134.0	2E8DB@1|root,332RT@2|Bacteria,2I0D2@201174|Actinobacteria,4FHB4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1049480_5	313589.JNB_01885	1.063e-198	642.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria,4FFC5@85021|Intrasporangiaceae	201174|Actinobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
TLS3_k127_1049480_17	367299.JOEE01000008_gene419	3.617e-124	407.0	COG1609@1|root,COG1609@2|Bacteria,2GKFC@201174|Actinobacteria,4FFT0@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS3_k127_1049480_7	367299.JOEE01000008_gene418	1.195e-181	578.0	COG1653@1|root,COG1653@2|Bacteria,2GJYT@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_1049480_9	367299.JOEE01000008_gene417	4.653e-178	570.0	COG1175@1|root,COG1175@2|Bacteria,2GMNK@201174|Actinobacteria,4FFDS@85021|Intrasporangiaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_1049480_11	367299.JOEE01000008_gene416	4.122e-145	466.0	COG0395@1|root,COG0395@2|Bacteria,2GITV@201174|Actinobacteria,4FEEU@85021|Intrasporangiaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_1049480_10	1074488.AGBX01000001_gene1263	2.542e-166	535.0	COG1972@1|root,COG1972@2|Bacteria,2IB7W@201174|Actinobacteria,4FBJ4@85020|Dermabacteraceae	201174|Actinobacteria	F	Na+ dependent nucleoside transporter C-terminus	yutK	-	-	ko:K03317,ko:K11535,ko:K16323	-	-	-	-	ko00000,ko02000	2.A.41,2.A.41.1	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
TLS3_k127_1049480_24	1122622.ATWJ01000001_gene2459	3.875e-38	148.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,4FGBM@85021|Intrasporangiaceae	201174|Actinobacteria	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	HicB,RHH_1
TLS3_k127_1049480_22	1122622.ATWJ01000001_gene2460	1.314e-61	224.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4FFH0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
TLS3_k127_105365_0	1906.SFRA_24355	4.718e-259	809.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria	201174|Actinobacteria	F	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS3_k127_105365_2	1906.SFRA_24350	2.879e-194	614.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS3_k127_105365_5	1298863.AUEP01000010_gene4505	2.259e-125	421.0	COG0372@1|root,COG0372@2|Bacteria,2H9YP@201174|Actinobacteria,4DSM0@85009|Propionibacteriales	201174|Actinobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_105365_3	397278.JOJN01000003_gene2096	5.979e-172	553.0	COG3384@1|root,COG3384@2|Bacteria,2GNCA@201174|Actinobacteria,4DRZ9@85009|Propionibacteriales	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	1.13.11.8	ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigB
TLS3_k127_105365_7	33876.JNXY01000014_gene3881	1.342e-59	210.0	2A2TQ@1|root,30R7G@2|Bacteria,2IMC8@201174|Actinobacteria,4DDVS@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_105365_10	1043205.AFYF01000083_gene1857	1.571e-35	151.0	2FEQY@1|root,346Q4@2|Bacteria,2GSR9@201174|Actinobacteria,4FH9B@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_105365_8	479431.Namu_0233	6.446e-43	160.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_105365_9	234621.RER_10260	6.344e-40	155.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4G8U5@85025|Nocardiaceae	201174|Actinobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
TLS3_k127_105365_4	1385518.N798_15555	1.289e-151	484.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4FFM8@85021|Intrasporangiaceae	201174|Actinobacteria	I	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS3_k127_105365_6	436229.JOEH01000021_gene7616	1.125e-72	254.0	COG2318@1|root,COG2318@2|Bacteria,2I1DJ@201174|Actinobacteria,2NIRF@228398|Streptacidiphilus	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS3_k127_105365_1	1385520.N802_06170	4.376e-211	666.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4FEDY@85021|Intrasporangiaceae	201174|Actinobacteria	L	RNA helicase	rhlE1	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS3_k127_1154630_8	1193181.BN10_130026	1.71e-72	246.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4FFE5@85021|Intrasporangiaceae	201174|Actinobacteria	EP	ABC transporter (Permease)	appCC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS3_k127_1154630_3	1193181.BN10_130027	1.589e-180	576.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4FEDF@85021|Intrasporangiaceae	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS3_k127_1154630_2	1193181.BN10_130028	1.706e-200	632.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4FEBA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS3_k127_1154630_9	1449347.JQLN01000004_gene7211	1.13e-37	154.0	COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
TLS3_k127_1154630_0	1193181.BN10_130032	8.541e-260	819.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4FE74@85021|Intrasporangiaceae	201174|Actinobacteria	G	4-alpha-glucanotransferase	malQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
TLS3_k127_1154630_5	1184609.KILIM_003_01030	6.704e-116	382.0	COG4874@1|root,COG4874@2|Bacteria,2GKVJ@201174|Actinobacteria	201174|Actinobacteria	S	amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
TLS3_k127_1154630_10	710111.FraQA3DRAFT_1160	3.126e-26	122.0	2E98C@1|root,333GS@2|Bacteria,2GSI7@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
TLS3_k127_1154630_12	1172188.KB911820_gene2449	1.025e-12	70.0	2EIY8@1|root,33CPE@2|Bacteria,2GXKK@201174|Actinobacteria,4FI0G@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1154630_1	136273.GY22_16485	5.852e-235	737.0	COG3037@1|root,COG3037@2|Bacteria,2GMYV@201174|Actinobacteria,1W7PB@1268|Micrococcaceae	201174|Actinobacteria	S	PTS system sugar-specific permease component	ulaA	-	-	ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.7.1	-	-	EIIC-GAT
TLS3_k127_1154630_6	1121362.A605_10685	1.574e-99	331.0	COG1762@1|root,COG3414@1|root,COG1762@2|Bacteria,COG3414@2|Bacteria,2I8CH@201174|Actinobacteria,22K58@1653|Corynebacteriaceae	201174|Actinobacteria	G	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)	ulaC	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	PTS_EIIA_2,PTS_IIB
TLS3_k127_1154630_11	211114.JOEF01000026_gene351	2.433e-16	85.0	COG0589@1|root,COG0589@2|Bacteria,2GSYN@201174|Actinobacteria,4E741@85010|Pseudonocardiales	201174|Actinobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_1154630_7	1172188.KB911822_gene922	6.712e-90	299.0	COG1432@1|root,COG1432@2|Bacteria,2GMV5@201174|Actinobacteria,4FGBU@85021|Intrasporangiaceae	201174|Actinobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
TLS3_k127_1154630_4	367299.JOEE01000011_gene3163	6.315e-116	376.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4FENW@85021|Intrasporangiaceae	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
TLS3_k127_116146_4	710696.Intca_2472	5.504e-06	54.0	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria,4FE4D@85021|Intrasporangiaceae	201174|Actinobacteria	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TLS3_k127_116146_3	1449044.JMLE01000028_gene267	5.358e-105	357.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,1WAIH@1268|Micrococcaceae	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_116146_0	1120954.ATXE01000001_gene2207	8.161e-229	734.0	COG0362@1|root,COG0362@2|Bacteria,2GJ2J@201174|Actinobacteria,4DQ33@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS3_k127_116146_1	1122622.ATWJ01000007_gene1889	2.823e-216	679.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria,4FFBW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TLS3_k127_116146_2	1122933.JNIY01000003_gene201	9.939e-109	369.0	COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria	201174|Actinobacteria	G	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
TLS3_k127_1248937_0	710696.Intca_1244	2.566e-231	719.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4FEHJ@85021|Intrasporangiaceae	201174|Actinobacteria	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_1248937_9	1385520.N802_07240	1.265e-56	208.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4FGRU@85021|Intrasporangiaceae	201174|Actinobacteria	H	Biotin protein ligase C terminal domain	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
TLS3_k127_1248937_3	1385519.N801_09130	2.547e-123	405.0	COG2114@1|root,COG2114@2|Bacteria,2GN02@201174|Actinobacteria,4FF0M@85021|Intrasporangiaceae	201174|Actinobacteria	T	adenylyl cyclase	cya	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Ad_Cy_reg,Guanylate_cyc
TLS3_k127_1248937_5	710696.Intca_1248	6.038e-101	334.0	COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria,4FEB0@85021|Intrasporangiaceae	201174|Actinobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	vicR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_1248937_4	313589.JNB_18453	1.934e-118	392.0	COG0642@1|root,COG0642@2|Bacteria,2GJIV@201174|Actinobacteria,4FE5Z@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
TLS3_k127_1248937_8	367299.JOEE01000003_gene3026	1.066e-61	217.0	COG2246@1|root,COG2246@2|Bacteria,2IFFV@201174|Actinobacteria,4FHCY@85021|Intrasporangiaceae	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
TLS3_k127_1248937_1	1385521.N803_15945	1.95e-190	602.0	COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria,4FER6@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
TLS3_k127_1248937_6	762963.HMPREF9056_00382	1.284e-77	263.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4D5TG@85005|Actinomycetales	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
TLS3_k127_1248937_7	1385519.N801_09100	6.195e-62	218.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria,4FGPZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS3_k127_1248937_2	1184609.KILIM_032_00090	2.493e-188	601.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4F72P@85018|Dermatophilaceae	201174|Actinobacteria	M	UDP binding domain	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS3_k127_1248937_10	367299.JOEE01000003_gene3020	2.403e-41	152.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FFGR@85021|Intrasporangiaceae	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_1270391_2	1385518.N798_03540	8.306e-81	274.0	COG0566@1|root,COG0566@2|Bacteria,2GP9S@201174|Actinobacteria,4FEGY@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
TLS3_k127_1270391_1	367299.JOEE01000002_gene2429	4.158e-112	365.0	COG0346@1|root,COG0346@2|Bacteria,2I5X0@201174|Actinobacteria,4FFUT@85021|Intrasporangiaceae	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
TLS3_k127_1270391_0	208439.AJAP_31775	1.023e-241	769.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DXGB@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_1297770_9	1193181.BN10_680082	4.346e-13	71.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4FIWM@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_1297770_0	1122622.ATWJ01000001_gene2463	6.924e-123	401.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria,4FGJ4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1297770_3	1385520.N802_16235	2.225e-80	271.0	COG1652@1|root,COG1652@2|Bacteria,2I1RI@201174|Actinobacteria,4FJ5F@85021|Intrasporangiaceae	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Gmad2,LysM
TLS3_k127_1297770_4	196162.Noca_1141	4.465e-57	203.0	COG0590@1|root,COG0590@2|Bacteria,2INAI@201174|Actinobacteria,4DQQ8@85009|Propionibacteriales	201174|Actinobacteria	FJ	MafB19-like deaminase	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
TLS3_k127_1297770_6	1313172.YM304_09960	9.528e-42	160.0	COG3837@1|root,COG3837@2|Bacteria	2|Bacteria	S	Cupin domain	-	-	3.4.13.22	ko:K08641,ko:K11312	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Cupin_2,HTH_18
TLS3_k127_1297770_2	1313172.YM304_09950	3.972e-117	394.0	COG0596@1|root,COG3947@1|root,COG0596@2|Bacteria,COG3947@2|Bacteria	2|Bacteria	T	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,BTAD,GerE,Guanylate_cyc,LysM,Response_reg,Trans_reg_C
TLS3_k127_1297770_7	1123251.ATWM01000006_gene2049	2.226e-29	122.0	2E3Y8@1|root,32YVA@2|Bacteria,2GUQF@201174|Actinobacteria,4FJJI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2945)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2945
TLS3_k127_1297770_5	1385520.N802_03105	3.391e-42	160.0	2CDCS@1|root,2ZQSD@2|Bacteria,2IPQF@201174|Actinobacteria,4FH6Y@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1297770_1	1172185.KB911509_gene269	2.003e-122	409.0	COG0477@1|root,COG2814@2|Bacteria,2GIZX@201174|Actinobacteria,4FXKU@85025|Nocardiaceae	201174|Actinobacteria	EGP	the major facilitator superfamily	-	-	-	ko:K18926	-	M00715	-	-	ko00000,ko00002,ko02000	2.A.1.3.30	-	-	MFS_1
TLS3_k127_1297770_8	1121385.AQXW01000002_gene16	2.497e-24	113.0	COG1309@1|root,COG1309@2|Bacteria,2GS0G@201174|Actinobacteria,1ZWYP@145357|Dermacoccaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_1307543_13	1151118.KB895784_gene3164	4.449e-14	76.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,1WAIH@1268|Micrococcaceae	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_1307543_1	2002.JOEQ01000026_gene342	7.947e-159	507.0	COG0657@1|root,COG0657@2|Bacteria,2GJYR@201174|Actinobacteria,4EHRV@85012|Streptosporangiales	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS3_k127_1307543_4	1077144.AGFF01000007_gene1706	2.507e-81	279.0	COG2846@1|root,COG2846@2|Bacteria,2IKUD@201174|Actinobacteria	201174|Actinobacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
TLS3_k127_1307543_3	1043205.AFYF01000004_gene1370	6.164e-94	323.0	COG0454@1|root,COG0456@2|Bacteria,2I0BW@201174|Actinobacteria,4FHU4@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_1307543_2	1193181.BN10_560009	9.233e-136	441.0	COG5285@1|root,COG5285@2|Bacteria,2GP77@201174|Actinobacteria,4FFDH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
TLS3_k127_1307543_6	1304874.JAFY01000002_gene169	7.826e-66	241.0	COG0500@1|root,COG2226@2|Bacteria,3TAMQ@508458|Synergistetes	508458|Synergistetes	Q	PFAM methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
TLS3_k127_1307543_8	1193181.BN10_420008	1.021e-46	171.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4FHRE@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS3_k127_1307543_0	1440053.JOEI01000009_gene5947	4.228e-177	573.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria	201174|Actinobacteria	G	trehalose synthase	malL	-	2.4.1.4,3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05341,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R01823,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459
TLS3_k127_1307543_7	1193181.BN10_960011	1.199e-59	220.0	COG3797@1|root,COG3797@2|Bacteria,2HXMC@201174|Actinobacteria,4FHCT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
TLS3_k127_1307543_10	405948.SACE_3647	3.295e-34	143.0	COG4978@1|root,COG4978@2|Bacteria,2IQMV@201174|Actinobacteria,4EBME@85010|Pseudonocardiales	201174|Actinobacteria	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
TLS3_k127_1307543_11	1193181.BN10_300009	5.287e-25	120.0	2DI8M@1|root,32UAP@2|Bacteria,2GR9W@201174|Actinobacteria,4FHVW@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS3_k127_1307543_12	164757.Mjls_2722	3.274e-24	105.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria,233RQ@1762|Mycobacteriaceae	201174|Actinobacteria	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
TLS3_k127_1307543_5	1121017.AUFG01000002_gene2738	1.056e-75	260.0	COG3832@1|root,COG3832@2|Bacteria,2IMFE@201174|Actinobacteria,4FJ8P@85021|Intrasporangiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_1307543_9	1122622.ATWJ01000013_gene235	2.128e-45	173.0	COG5549@1|root,COG5549@2|Bacteria,2ISZT@201174|Actinobacteria,4FJUS@85021|Intrasporangiaceae	201174|Actinobacteria	O	Matrixin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
TLS3_k127_1312568_10	935839.JAGJ01000005_gene2658	5.623e-58	204.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4F5HR@85017|Promicromonosporaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
TLS3_k127_1312568_6	1385518.N798_00815	7.921e-124	413.0	COG0300@1|root,COG3832@1|root,COG0300@2|Bacteria,COG3832@2|Bacteria,2IKZ7@201174|Actinobacteria,4FH5N@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_1312568_9	367299.JOEE01000006_gene869	1.505e-65	241.0	COG2203@1|root,COG2203@2|Bacteria,2I62P@201174|Actinobacteria,4FH8T@85021|Intrasporangiaceae	201174|Actinobacteria	K	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS3_k127_1312568_5	1169161.KB897741_gene1919	7.161e-124	411.0	COG1928@1|root,COG1928@2|Bacteria,2IRG1@201174|Actinobacteria	201174|Actinobacteria	O	C-terminal four TMM region of protein-O-mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1312568_13	457429.ABJI02000084_gene3077	1.352e-43	173.0	2AQ5P@1|root,31FB4@2|Bacteria,2IRT0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1312568_0	1123251.ATWM01000003_gene1015	1.105e-253	789.0	COG0786@1|root,COG0786@2|Bacteria,2I9AV@201174|Actinobacteria	201174|Actinobacteria	E	Sodium glutamate symporter	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
TLS3_k127_1312568_4	196162.Noca_1866	6.45e-151	486.0	28HGI@1|root,2Z7SC@2|Bacteria,2GKHQ@201174|Actinobacteria,4DPGV@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1312568_12	1114959.SZMC14600_10328	1.343e-43	168.0	COG5207@1|root,COG5207@2|Bacteria,2IKW9@201174|Actinobacteria,4E5S8@85010|Pseudonocardiales	201174|Actinobacteria	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
TLS3_k127_1312568_15	1380347.JNII01000008_gene4406	1.982e-08	61.0	2DNVA@1|root,32ZBE@2|Bacteria,2GRAT@201174|Actinobacteria,4EWV7@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1312568_8	1032480.MLP_51770	1.941e-79	276.0	COG5395@1|root,COG5395@2|Bacteria,2IHVI@201174|Actinobacteria,4DQNA@85009|Propionibacteriales	201174|Actinobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
TLS3_k127_1312568_7	1032480.MLP_51780	4.338e-83	282.0	2950P@1|root,2ZSDF@2|Bacteria,2IIVU@201174|Actinobacteria,4DUPS@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1312568_1	1032480.MLP_51790	6.944e-250	799.0	COG2909@1|root,COG2909@2|Bacteria,2I50W@201174|Actinobacteria,4DPMG@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
TLS3_k127_1312568_3	1386089.N865_04695	5.667e-152	504.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria,4FFVM@85021|Intrasporangiaceae	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,cNMP_binding
TLS3_k127_1312568_2	1386089.N865_04690	6.724e-246	770.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4FFVK@85021|Intrasporangiaceae	201174|Actinobacteria	KOT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
TLS3_k127_1312568_11	1380356.JNIK01000016_gene3488	1.066e-47	183.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_1312568_14	2045.KR76_25205	1.232e-19	91.0	COG0402@1|root,COG0402@2|Bacteria,2GKKM@201174|Actinobacteria,4DRJN@85009|Propionibacteriales	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_3
TLS3_k127_1323306_1	1120948.KB903219_gene623	0.0	1278.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DXVG@85010|Pseudonocardiales	201174|Actinobacteria	G	hydrolase, family 65, central catalytic	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
TLS3_k127_1323306_3	675635.Psed_3456	3.532e-253	798.0	COG0492@1|root,COG0664@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,2GK62@201174|Actinobacteria,4E1D0@85010|Pseudonocardiales	201174|Actinobacteria	C	Cyclic nucleotide-monophosphate binding domain	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
TLS3_k127_1323306_17	595537.Varpa_2483	1.092e-29	121.0	COG0025@1|root,COG0025@2|Bacteria,1QTZ5@1224|Proteobacteria,2WGIC@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
TLS3_k127_1323306_14	208444.JNYY01000015_gene3840	1.042e-54	212.0	COG3118@1|root,COG3118@2|Bacteria,2IHQV@201174|Actinobacteria,4E3P3@85010|Pseudonocardiales	201174|Actinobacteria	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
TLS3_k127_1323306_0	675635.Psed_2213	0.0	1411.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4E1A0@85010|Pseudonocardiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB2	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS3_k127_1323306_16	675635.Psed_3453	1.055e-32	145.0	COG0789@1|root,COG0789@2|Bacteria,2GRXI@201174|Actinobacteria,4E70T@85010|Pseudonocardiales	201174|Actinobacteria	K	MerR HTH family regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_2
TLS3_k127_1323306_7	1120948.KB903247_gene4438	2.247e-139	450.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4E1T9@85010|Pseudonocardiales	201174|Actinobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
TLS3_k127_1323306_15	1120948.KB903247_gene4439	1.204e-48	199.0	COG0576@1|root,COG0576@2|Bacteria,2IKK4@201174|Actinobacteria,4E4CV@85010|Pseudonocardiales	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE2	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS3_k127_1323306_2	2074.JNYD01000043_gene2282	1.146e-321	1005.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4DZEH@85010|Pseudonocardiales	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK2	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS3_k127_1323306_11	1120948.KB903243_gene2715	4.845e-70	245.0	2CAW2@1|root,31XMW@2|Bacteria,2INCS@201174|Actinobacteria,4EEBQ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1323306_12	675635.Psed_3451	1.493e-67	232.0	arCOG05087@1|root,31BBY@2|Bacteria,2ICGZ@201174|Actinobacteria,4E5T7@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF1931)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1931
TLS3_k127_1323306_10	1120948.KB903240_gene4025	1.638e-85	289.0	COG3707@1|root,COG3707@2|Bacteria,2IF8A@201174|Actinobacteria,4EE88@85010|Pseudonocardiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS3_k127_1323306_6	1120948.KB903240_gene4026	1.162e-196	625.0	COG2508@1|root,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria,4EEVN@85010|Pseudonocardiales	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
TLS3_k127_1323306_5	1120948.KB903240_gene4031	2.957e-237	745.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4E0CJ@85010|Pseudonocardiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-associated	fdh3	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS3_k127_1323306_13	1120948.KB903240_gene4032	1.336e-58	209.0	COG5637@1|root,COG5637@2|Bacteria,2IMUW@201174|Actinobacteria,4E7AV@85010|Pseudonocardiales	201174|Actinobacteria	S	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1323306_4	1120948.KB903240_gene4033	1.538e-241	751.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4E1EE@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Alcohol dehydrogenase GroES-like domain	fdhA	-	1.2.1.46	ko:K00148	ko00625,ko00680,ko01100,ko01120,ko01200,map00625,map00680,map01100,map01120,map01200	-	R00604	RC00188	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
TLS3_k127_1323306_8	1120948.KB903240_gene4034	2.823e-104	345.0	COG0693@1|root,COG0693@2|Bacteria,2GMMW@201174|Actinobacteria,4E2WM@85010|Pseudonocardiales	201174|Actinobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS3_k127_1323306_18	1120948.KB903240_gene4030	3.875e-16	80.0	COG2261@1|root,COG2261@2|Bacteria,2GQR5@201174|Actinobacteria,4E75F@85010|Pseudonocardiales	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS3_k127_1323306_9	1089544.KB912942_gene5951	8.992e-93	326.0	COG1476@1|root,COG1476@2|Bacteria,2H27T@201174|Actinobacteria,4EB0D@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
TLS3_k127_1323306_19	882083.SacmaDRAFT_4189	1.772e-13	76.0	2FJY7@1|root,34BKJ@2|Bacteria,2GSQD@201174|Actinobacteria,4ED8Y@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF397
TLS3_k127_1374117_1	313589.JNB_09789	5.517e-70	248.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria,4FE5E@85021|Intrasporangiaceae	201174|Actinobacteria	T	Signal transduction histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,His_kinase
TLS3_k127_1374117_2	1123024.AUII01000006_gene4608	3.817e-50	195.0	COG3247@1|root,COG3247@2|Bacteria	2|Bacteria	U	response to pH	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
TLS3_k127_1374117_0	1385518.N798_13305	1.268e-88	301.0	COG3177@1|root,COG3177@2|Bacteria,2GIT8@201174|Actinobacteria,4FFUU@85021|Intrasporangiaceae	201174|Actinobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
TLS3_k127_1393877_4	1120948.KB903233_gene4765	4.231e-264	823.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4E2GI@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_1393877_27	35754.JNYJ01000035_gene3916	1.738e-64	231.0	COG1266@1|root,COG1266@2|Bacteria,2GTZ4@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Abortive infection protein	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS3_k127_1393877_17	743718.Isova_1014	2.856e-107	359.0	COG0697@1|root,COG0697@2|Bacteria,2GMPB@201174|Actinobacteria	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter DMT superfamily	pecM	-	-	ko:K15269	-	-	-	-	ko00000,ko02000	2.A.7.3.3	-	-	EamA
TLS3_k127_1393877_20	1343740.M271_11760	1.072e-87	298.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_1393877_23	1045009.AFXQ01000035_gene2546	1.112e-72	247.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria,1WACD@1268|Micrococcaceae	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_1393877_39	1193181.BN10_720040	7.735e-14	72.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4FHJ7@85021|Intrasporangiaceae	201174|Actinobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
TLS3_k127_1393877_11	1386089.N865_00390	2.891e-154	498.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4FHS3@85021|Intrasporangiaceae	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
TLS3_k127_1393877_43	1121019.AUMN01000001_gene451	0.0002762	46.0	2C7CU@1|root,33J7G@2|Bacteria,2IRTH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1393877_33	1121019.AUMN01000001_gene452	3.111e-29	117.0	2E8MQ@1|root,332Z5@2|Bacteria,2GSZR@201174|Actinobacteria	201174|Actinobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS3_k127_1393877_31	935866.JAER01000024_gene3125	3.817e-36	141.0	COG3631@1|root,COG3631@2|Bacteria,2IMVY@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS3_k127_1393877_40	312284.A20C1_12777	8.508e-14	82.0	COG1359@1|root,COG1359@2|Bacteria,2IR36@201174|Actinobacteria	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS3_k127_1393877_41	290340.AAur_0361	1.07e-12	75.0	2AKGE@1|root,31B89@2|Bacteria,2IN2E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1393877_36	1385518.N798_12125	8.95e-18	92.0	2AKGE@1|root,30DHP@2|Bacteria,2I885@201174|Actinobacteria,4FH35@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1393877_37	479435.Kfla_3385	1.636e-15	85.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,4DS0U@85009|Propionibacteriales	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
TLS3_k127_1393877_14	313589.JNB_09879	2.301e-129	419.0	COG3409@1|root,COG3409@2|Bacteria,2I5WU@201174|Actinobacteria,4FEA8@85021|Intrasporangiaceae	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS3_k127_1393877_28	1385520.N802_14805	8.414e-57	224.0	COG1309@1|root,COG1309@2|Bacteria,2GN0W@201174|Actinobacteria,4FG11@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_1393877_5	1121017.AUFG01000015_gene2631	1.031e-212	681.0	COG0183@1|root,COG0183@2|Bacteria,2GJI8@201174|Actinobacteria,4FFR2@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadI	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_1393877_8	367299.JOEE01000008_gene509	2.427e-168	540.0	COG1028@1|root,COG1028@2|Bacteria,2GJCZ@201174|Actinobacteria,4FFTI@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_1393877_16	1385518.N798_08015	1.002e-114	383.0	COG2030@1|root,COG2030@2|Bacteria,2GNQQ@201174|Actinobacteria,4FFHW@85021|Intrasporangiaceae	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS3_k127_1393877_3	273677.BW34_01204	2.563e-268	835.0	COG0154@1|root,COG0154@2|Bacteria,2GMND@201174|Actinobacteria,4FMP2@85023|Microbacteriaceae	201174|Actinobacteria	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS3_k127_1393877_2	1193181.BN10_590078	6.051e-274	859.0	COG1506@1|root,COG1506@2|Bacteria,2GNG5@201174|Actinobacteria,4FF94@85021|Intrasporangiaceae	201174|Actinobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
TLS3_k127_1393877_42	743718.Isova_0403	3.716e-10	68.0	COG2866@1|root,COG2866@2|Bacteria,2GJ8D@201174|Actinobacteria,4F55J@85017|Promicromonosporaceae	201174|Actinobacteria	M	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS3_k127_1393877_32	1122622.ATWJ01000012_gene1007	1.043e-29	127.0	COG2866@1|root,COG2866@2|Bacteria,2GJ8D@201174|Actinobacteria,4FIBK@85021|Intrasporangiaceae	201174|Actinobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS3_k127_1393877_38	743718.Isova_0403	6.886e-14	79.0	COG2866@1|root,COG2866@2|Bacteria,2GJ8D@201174|Actinobacteria,4F55J@85017|Promicromonosporaceae	201174|Actinobacteria	M	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS3_k127_1393877_26	1380354.JIAN01000009_gene3870	1.503e-64	230.0	COG2154@1|root,COG2154@2|Bacteria,2IHZE@201174|Actinobacteria,4F2CY@85016|Cellulomonadaceae	201174|Actinobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
TLS3_k127_1393877_1	1385518.N798_07990	0.0	1140.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4FFPP@85021|Intrasporangiaceae	201174|Actinobacteria	J	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
TLS3_k127_1393877_19	313589.JNB_02380	7.48e-94	313.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4FF6E@85021|Intrasporangiaceae	201174|Actinobacteria	FG	HIT family hydrolase	-	GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
TLS3_k127_1393877_21	1121385.AQXW01000004_gene1077	1.403e-84	287.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,1ZVWU@145357|Dermacoccaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS3_k127_1393877_18	1385521.N803_07620	2.9e-102	351.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4FFN3@85021|Intrasporangiaceae	201174|Actinobacteria	M	lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
TLS3_k127_1393877_10	1386089.N865_15275	1.295e-155	501.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4FEF1@85021|Intrasporangiaceae	201174|Actinobacteria	M	GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
TLS3_k127_1393877_29	313589.JNB_02400	1.816e-55	199.0	COG1704@1|root,COG1704@2|Bacteria,2GK54@201174|Actinobacteria,4FGDG@85021|Intrasporangiaceae	201174|Actinobacteria	S	LemA family	-	-	-	-	-	-	-	-	-	-	-	-	LemA
TLS3_k127_1393877_9	1193181.BN10_590068	1.009e-167	535.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4FF4Y@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
TLS3_k127_1393877_22	1210046.B277_08285	3.019e-76	265.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4FG85@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
TLS3_k127_1393877_13	367299.JOEE01000008_gene533	7.203e-140	446.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4FEKM@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
TLS3_k127_1393877_24	1385519.N801_02100	1.178e-72	250.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4FGB1@85021|Intrasporangiaceae	201174|Actinobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
TLS3_k127_1393877_25	367299.JOEE01000008_gene535	4.985e-70	251.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,4FGIB@85021|Intrasporangiaceae	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
TLS3_k127_1393877_7	1193181.BN10_590056	1.142e-175	560.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4FEWP@85021|Intrasporangiaceae	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
TLS3_k127_1393877_35	1193181.BN10_590055	4.374e-23	102.0	COG1862@1|root,COG1862@2|Bacteria,2ISDF@201174|Actinobacteria,4FHUP@85021|Intrasporangiaceae	201174|Actinobacteria	U	Preprotein translocase subunit YajC	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
TLS3_k127_1393877_6	1385518.N798_07895	2.263e-181	585.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4FE48@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS3_k127_1393877_15	1385520.N802_14950	3.396e-122	413.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4FENY@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
TLS3_k127_1393877_30	1121272.KB903249_gene2489	5.678e-54	204.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4DD72@85008|Micromonosporales	201174|Actinobacteria	F	Phosphoribosyl transferase domain	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
TLS3_k127_1393877_0	1380370.JIBA01000013_gene1369	0.0	1177.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4FECQ@85021|Intrasporangiaceae	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
TLS3_k127_1393877_12	1385518.N798_07875	1.751e-149	485.0	COG3266@1|root,COG3266@2|Bacteria,2I2EC@201174|Actinobacteria,4FEAY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
TLS3_k127_158106_10	710696.Intca_3422	4.029e-55	201.0	COG0847@1|root,COG0847@2|Bacteria,2IKNT@201174|Actinobacteria,4FH6A@85021|Intrasporangiaceae	201174|Actinobacteria	L	EXOIII	dnaQ2	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
TLS3_k127_158106_2	1386089.N865_03310	8.544e-200	631.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4FFC4@85021|Intrasporangiaceae	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
TLS3_k127_158106_1	1385518.N798_05220	9.224e-247	776.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,2GNP7@201174|Actinobacteria,4FE8J@85021|Intrasporangiaceae	201174|Actinobacteria	I	acetyl-CoA carboxylase	accDA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_158106_7	1123251.ATWM01000003_gene1073	6.37e-131	425.0	COG0697@1|root,COG0697@2|Bacteria,2I9T9@201174|Actinobacteria,4FFPR@85021|Intrasporangiaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_158106_4	367299.JOEE01000001_gene1845	1.238e-160	524.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4FE7R@85021|Intrasporangiaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
TLS3_k127_158106_5	313589.JNB_17788	9.718e-154	493.0	COG1175@1|root,COG1175@2|Bacteria,2GKC2@201174|Actinobacteria,4FG02@85021|Intrasporangiaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
TLS3_k127_158106_3	367299.JOEE01000001_gene1843	1.907e-195	618.0	COG1653@1|root,COG1653@2|Bacteria,2GP9H@201174|Actinobacteria,4FF32@85021|Intrasporangiaceae	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_158106_0	1464048.JNZS01000012_gene3293	1.948e-276	872.0	COG1874@1|root,COG1874@2|Bacteria,2GMDT@201174|Actinobacteria,4D90Z@85008|Micromonosporales	201174|Actinobacteria	G	beta-galactosidase	bga1	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
TLS3_k127_158106_8	345341.KUTG_04487	3.925e-81	291.0	COG1349@1|root,COG1349@2|Bacteria,2H5X4@201174|Actinobacteria,4DY5K@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, deoR family	glpR	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
TLS3_k127_158106_6	1385518.N798_05250	1.993e-140	452.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4FFY6@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS3_k127_158106_9	1385520.N802_16130	1.494e-72	249.0	2DBC4@1|root,2Z8BS@2|Bacteria,2GYBF@201174|Actinobacteria,4FFCU@85021|Intrasporangiaceae	201174|Actinobacteria	S	Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid	bar	-	3.5.2.1,3.5.2.15	ko:K03383,ko:K19794	ko00240,ko00791,ko01100,ko01120,map00240,map00791,map01100,map01120	-	R02139,R05561,R10777	RC00632,RC00680,RC01423,RC03058	ko00000,ko00001,ko01000	-	-	-	Amido_AtzD_TrzD
TLS3_k127_1595863_3	1380370.JIBA01000012_gene3497	4.283e-227	712.0	COG3459@1|root,COG3459@2|Bacteria,2IA66@201174|Actinobacteria,4FFJ1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Putative glucoamylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glycoamylase
TLS3_k127_1595863_0	1304865.JAGF01000001_gene116	0.0	1535.0	COG3459@1|root,COG3459@2|Bacteria,2HXZT@201174|Actinobacteria,4F244@85016|Cellulomonadaceae	201174|Actinobacteria	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1595863_1	1380370.JIBA01000012_gene3498	2.029e-303	940.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FEVZ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 3 C-terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	F5_F8_type_C,Glyco_hydro_3,Glyco_hydro_3_C
TLS3_k127_1595863_5	443218.AS9A_3961	1.771e-128	425.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type branched-chain amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS3_k127_1595863_4	443218.AS9A_3959	4.65e-135	456.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_1595863_7	443218.AS9A_3958	1.823e-90	314.0	COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_1595863_2	443218.AS9A_3957	9.607e-239	760.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,235IH@1762|Mycobacteriaceae	201174|Actinobacteria	I	synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_1595863_6	443218.AS9A_3956	2.402e-104	346.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,23515@1762|Mycobacteriaceae	201174|Actinobacteria	E	amino acid	lptB_2	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_1595863_8	443218.AS9A_3955	1.28e-14	74.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,232CN@1762|Mycobacteriaceae	201174|Actinobacteria	E	amino acid	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS3_k127_1644119_4	1385520.N802_19165	2.546e-99	334.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4FFN4@85021|Intrasporangiaceae	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
TLS3_k127_1644119_5	367299.JOEE01000004_gene1179	1.474e-78	278.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4FEWG@85021|Intrasporangiaceae	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS3_k127_1644119_9	266940.Krad_1403	2.249e-42	165.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS3_k127_1644119_8	1210046.B277_09447	1.179e-63	219.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4FGSF@85021|Intrasporangiaceae	201174|Actinobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
TLS3_k127_1644119_2	367299.JOEE01000004_gene1175	1.667e-164	526.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4FE58@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,tRNA_m1G_MT
TLS3_k127_1644119_6	1385518.N798_04405	2.11e-72	256.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4FGPM@85021|Intrasporangiaceae	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
TLS3_k127_1644119_10	1121017.AUFG01000023_gene2127	4.179e-36	143.0	COG1837@1|root,COG1837@2|Bacteria,2IQ4C@201174|Actinobacteria,4FHEB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the UPF0109 family	-	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
TLS3_k127_1644119_7	1385519.N801_13510	2.434e-65	228.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4FGS1@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
TLS3_k127_1644119_0	1385519.N801_13475	3.428e-181	572.0	COG1228@1|root,COG1228@2|Bacteria,2GKRZ@201174|Actinobacteria,4FEA9@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS3_k127_1644119_3	1386089.N865_01170	7.58e-114	372.0	COG0596@1|root,COG0596@2|Bacteria,2I5X6@201174|Actinobacteria,4FEFI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Esterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_1644119_1	1385518.N798_04440	4.037e-179	566.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4FEYZ@85021|Intrasporangiaceae	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS3_k127_168827_6	1184607.AUCHE_02_01390	4.719e-100	329.0	COG3033@1|root,COG3033@2|Bacteria,2GKH3@201174|Actinobacteria,4F7IE@85018|Dermatophilaceae	201174|Actinobacteria	E	Beta-eliminating lyase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS3_k127_168827_5	1210046.B277_10284	3.418e-106	353.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,4FEGF@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycine betaine ABC transporter substrate-binding protein	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
TLS3_k127_168827_9	1385518.N798_10500	1.294e-88	298.0	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria,4FFWH@85021|Intrasporangiaceae	201174|Actinobacteria	E	ABC transporter (Permease)	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS3_k127_168827_7	1385519.N801_15120	1.779e-93	311.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria,4FGC9@85021|Intrasporangiaceae	201174|Actinobacteria	E	ABC transporter (Permease)	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
TLS3_k127_168827_3	1385519.N801_15125	9.208e-186	587.0	COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,4FF7J@85021|Intrasporangiaceae	201174|Actinobacteria	E	Glycine betaine ABC transporter	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
TLS3_k127_168827_13	710421.Mycch_0157	2.827e-13	76.0	COG3832@1|root,COG3832@2|Bacteria,2IJGV@201174|Actinobacteria,239DG@1762|Mycobacteriaceae	201174|Actinobacteria	S	cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_168827_1	1210046.B277_14708	1.45e-249	815.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,2GISC@201174|Actinobacteria,4FFBR@85021|Intrasporangiaceae	201174|Actinobacteria	L	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
TLS3_k127_168827_2	1386089.N865_05725	2.725e-205	653.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4FFPA@85021|Intrasporangiaceae	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS3_k127_168827_10	1121017.AUFG01000014_gene2002	1.735e-84	293.0	COG1266@1|root,COG1266@2|Bacteria,2IIE6@201174|Actinobacteria,4FF66@85021|Intrasporangiaceae	201174|Actinobacteria	F	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS3_k127_168827_11	710696.Intca_3485	9.666e-64	224.0	COG4405@1|root,COG4405@2|Bacteria,2IKQP@201174|Actinobacteria,4FGZY@85021|Intrasporangiaceae	201174|Actinobacteria	S	ASCH	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
TLS3_k127_168827_0	367299.JOEE01000001_gene1623	6.789e-254	793.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4FFVG@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS3_k127_168827_8	1380370.JIBA01000010_gene2417	9.41e-89	308.0	COG1408@1|root,COG1408@2|Bacteria,2GMST@201174|Actinobacteria,4FFHV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
TLS3_k127_168827_4	367299.JOEE01000001_gene1636	6.217e-108	360.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria,4FFWD@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA1	-	-	-	-	-	-	-	-	-	-	-	ECH_1
TLS3_k127_168827_12	710696.Intca_0056	8.24e-15	83.0	COG4086@1|root,COG4086@2|Bacteria,2GTEN@201174|Actinobacteria,4FHY0@85021|Intrasporangiaceae	201174|Actinobacteria	S	MT0933-like antitoxin protein	-	-	-	-	-	-	-	-	-	-	-	-	MT0933_antitox
TLS3_k127_1719722_0	1385520.N802_06495	8.623e-273	868.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4FFAH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ABC transporter	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
TLS3_k127_1719722_4	1385518.N798_00075	1.41e-116	382.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4FF61@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_1719722_3	1064537.AGSO01000007_gene3174	8.126e-133	437.0	COG3919@1|root,COG3919@2|Bacteria,2GM4D@201174|Actinobacteria,4FBI6@85020|Dermabacteraceae	201174|Actinobacteria	S	ATP-grasp	-	-	6.3.1.12	ko:K17810	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2
TLS3_k127_1719722_1	1172188.KB911820_gene2998	7.282e-242	759.0	COG3540@1|root,COG3540@2|Bacteria,2GNZ5@201174|Actinobacteria,4FEC8@85021|Intrasporangiaceae	201174|Actinobacteria	P	PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PhoD
TLS3_k127_1719722_5	863239.AFIZ01000047_gene581	2.482e-72	252.0	COG3001@1|root,COG3001@2|Bacteria,2GW7W@201174|Actinobacteria,22KWU@1653|Corynebacteriaceae	201174|Actinobacteria	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
TLS3_k127_1719722_2	1385521.N803_04025	4.548e-149	474.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4FF92@85021|Intrasporangiaceae	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS3_k127_1766689_1	1123251.ATWM01000009_gene2888	0.0	1075.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,4FFIA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
TLS3_k127_1766689_2	1121019.AUMN01000005_gene2717	4.55e-217	691.0	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,1W7YX@1268|Micrococcaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
TLS3_k127_1766689_4	1385521.N803_15425	3.484e-143	475.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4FFSU@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
TLS3_k127_1766689_6	1193181.BN10_620005	8.36e-33	130.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4FH9F@85021|Intrasporangiaceae	201174|Actinobacteria	K	Cold-shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS3_k127_1766689_7	1193181.BN10_620004	2.459e-22	104.0	2DRKZ@1|root,33C8D@2|Bacteria,2HXM0@201174|Actinobacteria,4FHBT@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1766689_5	1385521.N803_15335	6.651e-95	315.0	COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,4FGJA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
TLS3_k127_1766689_3	1193181.BN10_180002	9.954e-164	520.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4FFXK@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_1766689_0	1385519.N801_14240	0.0	1238.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4FEZN@85021|Intrasporangiaceae	201174|Actinobacteria	C	Fe-S oxidoreductase	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
TLS3_k127_1785188_8	1385521.N803_00405	1.816e-133	429.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4FE8U@85021|Intrasporangiaceae	201174|Actinobacteria	E	ATP-binding protein	gluA	-	-	ko:K10008	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.9	-	-	ABC_tran
TLS3_k127_1785188_2	1386089.N865_10050	3.368e-275	857.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FG72@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	alkK	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_1785188_6	196162.Noca_3726	1.05e-176	561.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4DQ58@85009|Propionibacteriales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	fadE17_1	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_1785188_9	1121385.AQXW01000004_gene1907	4.428e-93	336.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,1ZWHH@145357|Dermacoccaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	fadE18_2	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_1785188_1	1122622.ATWJ01000010_gene1392	2.83e-306	949.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FF1W@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS3_k127_1785188_0	1122622.ATWJ01000010_gene1391	2.827e-306	957.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FFM1@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
TLS3_k127_1785188_7	1122611.KB904007_gene7987	7.086e-158	511.0	COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria	201174|Actinobacteria	G	Major Facilitator	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
TLS3_k127_1785188_15	471853.Bcav_3881	4.937e-55	208.0	COG0596@1|root,COG0596@2|Bacteria,2I32Y@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_1785188_18	1120958.AULD01000005_gene2318	3.192e-50	182.0	COG3795@1|root,COG3795@2|Bacteria,2IMMY@201174|Actinobacteria,4FS3K@85023|Microbacteriaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS3_k127_1785188_16	390989.JOEG01000001_gene4867	3.034e-53	208.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,4DEWJ@85008|Micromonosporales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS3_k127_1785188_5	390989.JOEG01000001_gene4868	1.393e-180	584.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DAJE@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_1785188_24	1435356.Y013_19570	9.795e-08	59.0	2B35N@1|root,31VTJ@2|Bacteria,2H0SE@201174|Actinobacteria,4G4F8@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1785188_23	1158050.KB895470_gene2657	9.89e-23	103.0	COG3360@1|root,COG3360@2|Bacteria,2IQ6Z@201174|Actinobacteria,1WA05@1268|Micrococcaceae	201174|Actinobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
TLS3_k127_1785188_19	1068980.ARVW01000001_gene3516	6.24e-46	175.0	COG0216@1|root,COG0216@2|Bacteria,2I7Z4@201174|Actinobacteria,4E4UT@85010|Pseudonocardiales	201174|Actinobacteria	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
TLS3_k127_1785188_21	1306174.JODP01000006_gene3205	1.153e-33	138.0	COG3108@1|root,COG3108@2|Bacteria	2|Bacteria	S	Peptidase M15	-	-	3.4.17.14	ko:K08640	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	PG_binding_1,Peptidase_M15_3
TLS3_k127_1785188_20	208439.AJAP_11775	1.948e-43	178.0	COG0778@1|root,COG0778@2|Bacteria,2I97S@201174|Actinobacteria,4E0AW@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS3_k127_1785188_10	1713.JOFV01000012_gene784	2.518e-89	302.0	COG1073@1|root,COG1073@2|Bacteria,2I2KN@201174|Actinobacteria,4F25W@85016|Cellulomonadaceae	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
TLS3_k127_1785188_13	397278.JOJN01000004_gene1386	2.736e-71	243.0	COG0640@1|root,COG0640@2|Bacteria,2HA3W@201174|Actinobacteria,4DT8H@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_1785188_11	397278.JOJN01000004_gene1385	1.604e-84	284.0	COG0412@1|root,COG0412@2|Bacteria,2GTZG@201174|Actinobacteria,4DQFU@85009|Propionibacteriales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
TLS3_k127_1785188_14	1385519.N801_15375	4.157e-68	241.0	299E4@1|root,2ZWGX@2|Bacteria,2GM90@201174|Actinobacteria,4FGEC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3145
TLS3_k127_1785188_3	1385518.N798_02800	4.242e-262	813.0	COG4799@1|root,COG4799@2|Bacteria,2I16G@201174|Actinobacteria,4FFW4@85021|Intrasporangiaceae	201174|Actinobacteria	I	Propionyl-CoA carboxylase subunit beta	accD6	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009317,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:1901575,GO:1901576,GO:1902494	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18472	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04386	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_1785188_4	1122622.ATWJ01000007_gene1993	2.706e-183	582.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4FEEV@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
TLS3_k127_1785188_22	1385518.N798_02790	5.931e-33	138.0	COG0236@1|root,COG0236@2|Bacteria,2IQ43@201174|Actinobacteria,4FH9D@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
TLS3_k127_1785188_12	1385520.N802_00410	6.261e-77	259.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4FFHC@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005488,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0019637,GO:0019693,GO:0019752,GO:0030497,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033818,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035336,GO:0035337,GO:0035383,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901567,GO:1901568,GO:1901576,GO:1901681	2.3.1.180	ko:K00648,ko:K11608	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iNJ661.Rv0533c	ACP_syn_III,ACP_syn_III_C
TLS3_k127_1807217_5	926550.CLDAP_13750	2.124e-98	338.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi	200795|Chloroflexi	M	LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS3_k127_1807217_10	1463864.JOGO01000031_gene4234	7.92e-05	51.0	2E4Q9@1|root,32ZIV@2|Bacteria,2II59@201174|Actinobacteria	201174|Actinobacteria	S	Putative transmembrane protein (PGPGW)	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
TLS3_k127_1807217_2	47763.JNZA01000041_gene250	1.975e-140	465.0	COG3497@1|root,COG3497@2|Bacteria,2GMJA@201174|Actinobacteria	201174|Actinobacteria	S	tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
TLS3_k127_1807217_6	1032480.MLP_38290	7.96e-94	317.0	COG2207@1|root,COG2207@2|Bacteria,2GM8I@201174|Actinobacteria,4DT6X@85009|Propionibacteriales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
TLS3_k127_1807217_7	1032480.MLP_38300	1.694e-70	242.0	29KMP@1|root,307IZ@2|Bacteria,2GWIU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
TLS3_k127_1807217_8	1385521.N803_10190	2.962e-61	222.0	COG3550@1|root,COG3550@2|Bacteria,2I2QD@201174|Actinobacteria,4FG8P@85021|Intrasporangiaceae	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS3_k127_1807217_0	1122622.ATWJ01000001_gene2577	1.164e-175	561.0	COG2114@1|root,COG2114@2|Bacteria,2HSA4@201174|Actinobacteria,4FEQT@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	cya	GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
TLS3_k127_1807217_1	710696.Intca_1099	2.845e-144	469.0	COG0715@1|root,COG0715@2|Bacteria,2HFVA@201174|Actinobacteria,4FI0M@85021|Intrasporangiaceae	201174|Actinobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
TLS3_k127_1807217_4	710696.Intca_1100	9.722e-125	414.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria,4FHKY@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter (Permease)	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
TLS3_k127_1807217_3	710696.Intca_1101	2.075e-126	412.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4FH4U@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter, ATP-binding protein	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
TLS3_k127_1807217_9	1121933.AUHH01000044_gene3180	1.458e-24	104.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
TLS3_k127_1821959_2	1121017.AUFG01000029_gene459	4.92e-97	321.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4FEU1@85021|Intrasporangiaceae	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
TLS3_k127_1821959_4	1184609.KILIM_019_00610	4.471e-58	206.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4F73W@85018|Dermatophilaceae	201174|Actinobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
TLS3_k127_1821959_0	1172188.KB911820_gene2697	6.868e-261	818.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FEUF@85021|Intrasporangiaceae	201174|Actinobacteria	V	Multidrug ABC transporter ATPase	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_1821959_8	1172188.KB911820_gene2698	3.634e-26	115.0	COG1846@1|root,COG1846@2|Bacteria,2IHP0@201174|Actinobacteria,4FHFS@85021|Intrasporangiaceae	201174|Actinobacteria	K	MarR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_1821959_5	710696.Intca_1104	1.73e-56	200.0	COG1018@1|root,COG1018@2|Bacteria,2GSMZ@201174|Actinobacteria	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	Fer2
TLS3_k127_1821959_1	710696.Intca_1103	4.63e-155	496.0	COG0346@1|root,COG0346@2|Bacteria,2GKY9@201174|Actinobacteria,4FJF1@85021|Intrasporangiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
TLS3_k127_1821959_7	710696.Intca_1102	2.502e-32	131.0	COG3193@1|root,COG3193@2|Bacteria,2HNGS@201174|Actinobacteria,4FJMX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
TLS3_k127_1821959_3	710696.Intca_1098	2.246e-79	279.0	COG1414@1|root,COG1414@2|Bacteria,2HGKN@201174|Actinobacteria,4FJ9Y@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS3_k127_1821959_6	710696.Intca_1097	1.263e-33	148.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4FHUI@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS3_k127_1824673_16	367299.JOEE01000007_gene215	1.089e-14	74.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4FEWZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
TLS3_k127_1824673_14	246196.MSMEI_2350	4.604e-59	211.0	COG4243@1|root,COG4243@2|Bacteria,2GMVK@201174|Actinobacteria,232SR@1762|Mycobacteriaceae	201174|Actinobacteria	S	Vitamin K epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
TLS3_k127_1824673_13	1385519.N801_12985	9.764e-62	217.0	COG1846@1|root,COG1846@2|Bacteria,2GJ6W@201174|Actinobacteria,4FGMI@85021|Intrasporangiaceae	201174|Actinobacteria	K	MarR family transcriptional regulator	pecS	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_1824673_9	1385519.N801_12980	3.902e-99	335.0	COG4106@1|root,COG4106@2|Bacteria,2GJMG@201174|Actinobacteria,4FFAF@85021|Intrasporangiaceae	201174|Actinobacteria	E	Trans-aconitate methyltransferase	tam	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0051704	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25
TLS3_k127_1824673_10	367299.JOEE01000007_gene210	9.934e-98	325.0	COG1309@1|root,COG1309@2|Bacteria,2GMBW@201174|Actinobacteria,4FF8T@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	icaR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_1824673_4	1172188.KB911824_gene3393	1.76e-193	611.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4FEJ6@85021|Intrasporangiaceae	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_1824673_2	36809.MAB_3800c	4.65e-233	731.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,23727@1762|Mycobacteriaceae	201174|Actinobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS3_k127_1824673_8	1386089.N865_19280	9.167e-109	357.0	COG1349@1|root,COG1349@2|Bacteria,2GKWM@201174|Actinobacteria,4FGI5@85021|Intrasporangiaceae	201174|Actinobacteria	K	DeoR C terminal sensor domain	fruR	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
TLS3_k127_1824673_6	1172188.KB911820_gene2453	3.585e-126	412.0	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria,4FG6U@85021|Intrasporangiaceae	201174|Actinobacteria	G	Phosphomethylpyrimidine kinase	fruK	-	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
TLS3_k127_1824673_0	1386089.N865_19270	3e-323	1001.0	COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,2GJU4@201174|Actinobacteria,4FG55@85021|Intrasporangiaceae	201174|Actinobacteria	G	Phosphotransferase system, EIIC	fruA	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
TLS3_k127_1824673_15	1172188.KB911820_gene2455	1.89e-38	147.0	COG1925@1|root,COG1925@2|Bacteria,2GQX6@201174|Actinobacteria,4FHD9@85021|Intrasporangiaceae	201174|Actinobacteria	G	PTS HPr component phosphorylation site	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0051179,GO:0051234,GO:0071702	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
TLS3_k127_1824673_1	1386089.N865_19260	1.268e-264	829.0	COG1080@1|root,COG1080@2|Bacteria,2GIZZ@201174|Actinobacteria,4FG92@85021|Intrasporangiaceae	201174|Actinobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
TLS3_k127_1824673_3	1385518.N798_11755	2.57e-222	698.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4FEQE@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
TLS3_k127_1824673_5	367299.JOEE01000007_gene205	3.515e-175	556.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4FE7Y@85021|Intrasporangiaceae	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS3_k127_1824673_12	1193181.BN10_920017	8.462e-69	238.0	COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria,4FGX9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
TLS3_k127_1824673_7	367299.JOEE01000007_gene203	1.919e-114	378.0	COG0697@1|root,COG0697@2|Bacteria,2GKVT@201174|Actinobacteria,4FF7Q@85021|Intrasporangiaceae	201174|Actinobacteria	EG	EamA-like transporter family	ydeD	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_1824673_11	1385518.N798_11735	1.969e-95	317.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4FE4J@85021|Intrasporangiaceae	201174|Actinobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
TLS3_k127_1840141_6	367299.JOEE01000003_gene2773	4.84e-75	257.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4FF93@85021|Intrasporangiaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
TLS3_k127_1840141_10	953739.SVEN_2405	3.363e-06	50.0	2C821@1|root,3019I@2|Bacteria,2HD9F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1840141_5	367299.JOEE01000003_gene2776	6.076e-82	284.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria,4FF0U@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
TLS3_k127_1840141_3	1380370.JIBA01000002_gene2676	8.743e-90	308.0	COG2208@1|root,COG2208@2|Bacteria,2GNS3@201174|Actinobacteria,4FECV@85021|Intrasporangiaceae	201174|Actinobacteria	KT	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
TLS3_k127_1840141_7	1385521.N803_01355	5.245e-73	248.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4FGPP@85021|Intrasporangiaceae	201174|Actinobacteria	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
TLS3_k127_1840141_4	367299.JOEE01000003_gene2779	1.794e-83	303.0	COG3917@1|root,COG3917@2|Bacteria,2I2EX@201174|Actinobacteria,4FJYS@85021|Intrasporangiaceae	201174|Actinobacteria	Q	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS3_k127_1840141_0	367299.JOEE01000003_gene2780	0.0	1208.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4FE8H@85021|Intrasporangiaceae	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS3_k127_1840141_1	1193181.BN10_940021	2.871e-119	390.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4FF0H@85021|Intrasporangiaceae	201174|Actinobacteria	M	mechanosensitive ion channel protein MscS	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
TLS3_k127_1840141_9	1385520.N802_01500	1.054e-60	216.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria,4FGWI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial-like globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
TLS3_k127_1840141_2	1146883.BLASA_2982	4.849e-92	316.0	COG2807@1|root,COG2807@2|Bacteria,2GP5W@201174|Actinobacteria,4EVM7@85013|Frankiales	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K03449	-	-	-	-	ko00000,ko02000	2.A.1.17	-	-	MFS_1
TLS3_k127_1840141_8	1385518.N798_06515	7.281e-70	244.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4FFVB@85021|Intrasporangiaceae	201174|Actinobacteria	G	alpha-glucosidase	aglA	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
TLS3_k127_1917270_2	1193181.BN10_680039	3.656e-174	550.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4FESB@85021|Intrasporangiaceae	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
TLS3_k127_1917270_9	1121017.AUFG01000015_gene2661	1.119e-44	175.0	COG3153@1|root,COG3153@2|Bacteria,2IKX0@201174|Actinobacteria,4FH23@85021|Intrasporangiaceae	201174|Actinobacteria	S	Acetyltransferase	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
TLS3_k127_1917270_10	446462.Amir_3520	9.59e-32	137.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5W6@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_1917270_12	762948.HMPREF0733_10179	1.096e-28	118.0	COG2261@1|root,COG2261@2|Bacteria,2IQY7@201174|Actinobacteria,1WAB6@1268|Micrococcaceae	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS3_k127_1917270_5	1193181.BN10_680046	7.478e-100	337.0	COG1247@1|root,COG1670@1|root,COG1247@2|Bacteria,COG1670@2|Bacteria,2I3A5@201174|Actinobacteria,4FFUF@85021|Intrasporangiaceae	201174|Actinobacteria	JM	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_3
TLS3_k127_1917270_0	367299.JOEE01000009_gene258	0.0	1027.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,4FENV@85021|Intrasporangiaceae	201174|Actinobacteria	KL	ATP-dependent helicase	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
TLS3_k127_1917270_3	1385521.N803_00740	5.596e-131	428.0	COG1466@1|root,COG1466@2|Bacteria,2GNMZ@201174|Actinobacteria,4FIBW@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
TLS3_k127_1917270_11	1385518.N798_15980	2.177e-31	128.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4FHIY@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
TLS3_k127_1917270_7	367299.JOEE01000009_gene263	8.104e-66	233.0	COG2337@1|root,COG2337@2|Bacteria,2GM10@201174|Actinobacteria,4FGCI@85021|Intrasporangiaceae	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PemK_toxin
TLS3_k127_1917270_4	710696.Intca_2155	8.38e-125	409.0	COG1840@1|root,COG1840@2|Bacteria,2HG0I@201174|Actinobacteria,4FG0P@85021|Intrasporangiaceae	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
TLS3_k127_1917270_1	710696.Intca_2154	1.599e-183	588.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria,4FFG6@85021|Intrasporangiaceae	201174|Actinobacteria	P	Iron ABC transporter permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
TLS3_k127_1917270_6	443255.SCLAV_4934	2.868e-98	336.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
TLS3_k127_1917270_8	1385521.N803_00715	6.884e-45	164.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4FEI5@85021|Intrasporangiaceae	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS3_k127_1935197_2	1385518.N798_06435	1.067e-31	128.0	COG3427@1|root,COG3427@2|Bacteria,2HXJU@201174|Actinobacteria,4FH7T@85021|Intrasporangiaceae	201174|Actinobacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_1935197_1	1121017.AUFG01000003_gene3419	1.807e-89	309.0	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria,4FEMA@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
TLS3_k127_1935197_0	1386089.N865_11775	1.119e-94	317.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4FF5J@85021|Intrasporangiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	chcB	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS3_k127_1935197_3	1385518.N798_06450	7.431e-26	108.0	2E39N@1|root,32Y97@2|Bacteria,2GQFF@201174|Actinobacteria,4FHRB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3117
TLS3_k127_1937709_14	367299.JOEE01000002_gene2389	1.452e-131	432.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4FFEF@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_1937709_4	1386089.N865_20925	6.799e-211	664.0	COG1524@1|root,2Z9VM@2|Bacteria,2GWA2@201174|Actinobacteria,4FG2M@85021|Intrasporangiaceae	201174|Actinobacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1937709_23	1172188.KB911823_gene343	4.451e-66	239.0	COG1075@1|root,COG1075@2|Bacteria,2I44I@201174|Actinobacteria,4FJC2@85021|Intrasporangiaceae	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
TLS3_k127_1937709_24	367299.JOEE01000001_gene1621	2.76e-65	233.0	2CIBE@1|root,32S7P@2|Bacteria,2IRU5@201174|Actinobacteria,4FEWK@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1937709_19	1123251.ATWM01000001_gene810	4.224e-74	258.0	COG0572@1|root,COG0572@2|Bacteria,2I9H4@201174|Actinobacteria,4FGMW@85021|Intrasporangiaceae	201174|Actinobacteria	F	Fructose transport system kinase	frcK	-	-	-	-	-	-	-	-	-	-	-	ArgK,PRK
TLS3_k127_1937709_20	1283287.KB822577_gene3079	3.989e-71	243.0	2DK0G@1|root,30823@2|Bacteria,2IJ7K@201174|Actinobacteria,4DQVI@85009|Propionibacteriales	201174|Actinobacteria	S	Rifampin ADP-ribosyl transferase	arr	-	-	ko:K19062	-	-	-	-	ko00000,ko01504	-	-	-	Arr-ms
TLS3_k127_1937709_32	208444.JNYY01000005_gene6654	2.49e-12	72.0	2DQ4Z@1|root,334SM@2|Bacteria,2GWJC@201174|Actinobacteria,4E7K9@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF2568)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2568
TLS3_k127_1937709_11	367299.JOEE01000002_gene2383	9.808e-140	455.0	COG0477@1|root,COG2814@2|Bacteria,2GKMQ@201174|Actinobacteria,4FEMB@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_1937709_13	1035308.AQYY01000001_gene2111	2.275e-134	441.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
TLS3_k127_1937709_2	367299.JOEE01000002_gene2378	4.07e-234	747.0	COG1276@1|root,COG3336@1|root,COG1276@2|Bacteria,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4FFHN@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cytochrome C oxidase assembly protein	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
TLS3_k127_1937709_16	1385519.N801_01990	1.127e-94	318.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4FE90@85021|Intrasporangiaceae	201174|Actinobacteria	S	apolipoprotein N-acyltransferase	mtnU	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_1937709_31	1385518.N798_10385	2.5e-22	108.0	2DRBI@1|root,33B4D@2|Bacteria,2GUQT@201174|Actinobacteria,4FHW9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1937709_1	1385518.N798_15200	8.773e-270	845.0	COG0477@1|root,COG2814@2|Bacteria,2H32P@201174|Actinobacteria,4FJYZ@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_1937709_29	367299.JOEE01000002_gene2381	9.846e-35	140.0	COG1846@1|root,COG1846@2|Bacteria,2IG43@201174|Actinobacteria,4FGKV@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_1937709_26	1385520.N802_03180	4.38e-55	204.0	2DMQ5@1|root,32SZ1@2|Bacteria,2I3N2@201174|Actinobacteria,4FJYY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS3_k127_1937709_0	1385519.N801_15205	0.0	1076.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4FEU0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Butyryl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
TLS3_k127_1937709_21	1386089.N865_15145	4.17e-71	245.0	COG0386@1|root,COG0386@2|Bacteria,2IFJH@201174|Actinobacteria,4FGCK@85021|Intrasporangiaceae	201174|Actinobacteria	O	Belongs to the glutathione peroxidase family	gpo	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
TLS3_k127_1937709_27	1032480.MLP_22000	7.675e-43	163.0	COG4430@1|root,COG4430@2|Bacteria,2IN25@201174|Actinobacteria,4DSK1@85009|Propionibacteriales	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
TLS3_k127_1937709_6	1122622.ATWJ01000015_gene592	2.628e-158	514.0	COG0665@1|root,COG0665@2|Bacteria,2GMR7@201174|Actinobacteria,4FEMV@85021|Intrasporangiaceae	201174|Actinobacteria	E	D-amino acid	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_3
TLS3_k127_1937709_10	367299.JOEE01000001_gene1702	4.18e-145	467.0	COG0454@1|root,COG0456@2|Bacteria,2HX7T@201174|Actinobacteria,4FFK4@85021|Intrasporangiaceae	201174|Actinobacteria	K	N-acetyltransferase GCN5	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_1937709_7	1068978.AMETH_2822	1.193e-155	518.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4DX5K@85010|Pseudonocardiales	201174|Actinobacteria	Q	Cytochrome P450	cyp140	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_1937709_8	1122622.ATWJ01000015_gene513	5.275e-152	493.0	COG0477@1|root,COG0477@2|Bacteria,2I48M@201174|Actinobacteria,4FK19@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS3_k127_1937709_5	1193181.BN10_120007	2.056e-182	583.0	COG0397@1|root,COG0397@2|Bacteria,2GNRX@201174|Actinobacteria,4FFFV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized ACR, YdiU/UPF0061 family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
TLS3_k127_1937709_28	105420.BBPO01000028_gene6843	3.722e-39	166.0	COG1846@1|root,COG1846@2|Bacteria,2GP6A@201174|Actinobacteria,2NIH5@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS3_k127_1937709_18	196162.Noca_1869	9.612e-75	256.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4DQM8@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the UPF0312 family	yceI	-	-	-	-	-	-	-	-	-	-	-	YceI
TLS3_k127_1937709_15	1172188.KB911821_gene2007	3.614e-95	319.0	COG0300@1|root,COG0300@2|Bacteria,2I2RM@201174|Actinobacteria,4FHWN@85021|Intrasporangiaceae	201174|Actinobacteria	S	KR domain	-	-	1.1.1.105	ko:K15734	ko00830,map00830	-	R02124	RC00649	ko00000,ko00001,ko01000	-	-	-	adh_short
TLS3_k127_1937709_30	367299.JOEE01000002_gene2533	3.768e-32	141.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria,4FGBD@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
TLS3_k127_1937709_22	367299.JOEE01000007_gene109	1.239e-67	246.0	2EWJ7@1|root,33PXD@2|Bacteria,2I62Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1937709_3	1386089.N865_16865	1.027e-212	670.0	COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria,4FF3T@85021|Intrasporangiaceae	201174|Actinobacteria	HJ	Belongs to the RimK family	rimK	-	6.3.2.43	ko:K05827,ko:K05844	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RimK,TrkA_C
TLS3_k127_1937709_25	1043205.AFYF01000022_gene704	9.473e-63	219.0	COG4067@1|root,COG4067@2|Bacteria,2IJ20@201174|Actinobacteria,4FH5B@85021|Intrasporangiaceae	201174|Actinobacteria	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
TLS3_k127_1937709_12	1122622.ATWJ01000012_gene1092	1.859e-136	448.0	COG1444@1|root,COG1670@1|root,COG1444@2|Bacteria,COG1670@2|Bacteria,2IIWF@201174|Actinobacteria,4FJV1@85021|Intrasporangiaceae	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128,2.3.1.82	ko:K00663,ko:K03790	-	-	-	-	ko00000,ko01000,ko01504,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
TLS3_k127_1937709_9	1385521.N803_16130	4.495e-151	489.0	COG3608@1|root,COG3608@2|Bacteria,2IC8T@201174|Actinobacteria,4FFHR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Succinylglutamate desuccinylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
TLS3_k127_1937709_17	1193181.BN10_120015	7.469e-84	280.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4FFNJ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS3_k127_19657_2	103733.JNYO01000021_gene6813	8.233e-31	137.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria,4DZJG@85010|Pseudonocardiales	201174|Actinobacteria	T	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,WD40
TLS3_k127_19657_0	1206741.BAFX01000005_gene5816	2.602e-217	683.0	COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4FVI9@85025|Nocardiaceae	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
TLS3_k127_19657_1	1193181.BN10_590076	7.617e-171	564.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4FEQA@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cyclopropane-fatty-acyl-phospholipid synthase	cfa	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
TLS3_k127_1987377_5	367299.JOEE01000001_gene1759	1.154e-54	216.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4FEQ0@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA helicase	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C_2
TLS3_k127_1987377_0	1385518.N798_01150	5.856e-193	612.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4FE4R@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the GARS family	purD	GO:0008150,GO:0040007	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
TLS3_k127_1987377_10	1128427.KB904821_gene368	1.292e-05	57.0	2AKF7@1|root,31B6Q@2|Bacteria,1G5KA@1117|Cyanobacteria,1HAQJ@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1987377_1	1193181.BN10_650036	4.674e-152	494.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4FG0Z@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
TLS3_k127_1987377_3	1184609.KILIM_022_00680	4.762e-73	258.0	COG0784@1|root,COG0784@2|Bacteria,2I5BS@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1987377_6	1151122.AQYD01000005_gene3556	5.801e-46	178.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4FNDU@85023|Microbacteriaceae	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_1987377_7	367299.JOEE01000002_gene2294	2.322e-14	74.0	2CIG4@1|root,33C84@2|Bacteria,2GWMV@201174|Actinobacteria,4FI65@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1987377_2	367299.JOEE01000002_gene2293	6.182e-105	348.0	28P5T@1|root,2ZC0N@2|Bacteria,2GP34@201174|Actinobacteria,4FEI8@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1987377_9	443218.AS9A_2339	6.728e-08	58.0	291UT@1|root,2ZPEM@2|Bacteria,2H9SK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_1987377_4	1112204.GPOL_c02550	4.262e-57	205.0	COG1247@1|root,COG1247@2|Bacteria,2ISV7@201174|Actinobacteria,4GH7T@85026|Gordoniaceae	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_2022752_10	710696.Intca_0722	1.264e-27	112.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4FEGW@85021|Intrasporangiaceae	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
TLS3_k127_2022752_2	313589.JNB_09704	3.891e-224	708.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FEEW@85021|Intrasporangiaceae	201174|Actinobacteria	V	Multidrug ABC transporter ATP-binding protein	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_2022752_0	367299.JOEE01000001_gene1899	1.89e-299	932.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FFHB@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	yfiC	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_2022752_4	1380370.JIBA01000013_gene1613	4.582e-138	446.0	COG0451@1|root,COG0451@2|Bacteria,2GK8K@201174|Actinobacteria,4FGXM@85021|Intrasporangiaceae	201174|Actinobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS3_k127_2022752_3	1380370.JIBA01000013_gene1612	4.913e-169	539.0	COG4671@1|root,COG4671@2|Bacteria,2IAST@201174|Actinobacteria,4FHN0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
TLS3_k127_2022752_8	1120950.KB892801_gene1665	2.044e-86	312.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_2022752_5	1120950.KB892801_gene1666	1.463e-119	400.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4DSH1@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_2022752_7	1380370.JIBA01000013_gene1609	8.338e-88	309.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_2022752_1	1380370.JIBA01000013_gene1608	6.003e-284	891.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FG74@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_2066406_1	1035308.AQYY01000001_gene2149	1.879e-216	687.0	COG0471@1|root,COG0471@2|Bacteria	2|Bacteria	P	metal ion transport	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS3_k127_2066406_2	1035308.AQYY01000001_gene3491	9.92e-182	582.0	COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,248KF@186801|Clostridia	186801|Clostridia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS3_k127_2066406_11	935839.JAGJ01000024_gene2472	9.628e-17	85.0	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria,4F5YC@85017|Promicromonosporaceae	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
TLS3_k127_2066406_10	68199.JNZO01000008_gene7629	6.036e-28	125.0	2CXR2@1|root,32T2F@2|Bacteria,2I2M0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2066406_12	479431.Namu_1351	1.565e-15	82.0	COG3187@1|root,COG3187@2|Bacteria,2HRWJ@201174|Actinobacteria,4EWBE@85013|Frankiales	201174|Actinobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
TLS3_k127_2066406_8	1380370.JIBA01000013_gene1329	1.394e-77	275.0	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria,4FFGA@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
TLS3_k127_2066406_4	1429046.RR21198_1937	1.904e-102	366.0	COG2909@1|root,COG2909@2|Bacteria,2IARV@201174|Actinobacteria,4G8KB@85025|Nocardiaceae	201174|Actinobacteria	K	ATPases associated with a variety of cellular activities	pknK	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE,Pkinase
TLS3_k127_2066406_9	590998.Celf_1567	2.401e-63	234.0	COG2220@1|root,COG2220@2|Bacteria,2GN98@201174|Actinobacteria,4F149@85016|Cellulomonadaceae	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_2066406_3	1385518.N798_01695	2.015e-151	484.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4FEIZ@85021|Intrasporangiaceae	201174|Actinobacteria	C	NAD(P)H quinone oxidoreductase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
TLS3_k127_2066406_5	367299.JOEE01000001_gene1676	1.754e-100	333.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4FF83@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS3_k127_2066406_7	768671.ThimaDRAFT_0180	2.744e-89	305.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,1RNMT@1236|Gammaproteobacteria,1WXIM@135613|Chromatiales	135613|Chromatiales	P	PFAM Ion transport	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
TLS3_k127_2066406_0	367299.JOEE01000001_gene1686	4.332e-247	774.0	COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria,4FFCG@85021|Intrasporangiaceae	201174|Actinobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
TLS3_k127_2066406_6	367299.JOEE01000001_gene1688	2.095e-91	302.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,4FERC@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
TLS3_k127_2105756_25	1210046.B277_01065	6.487e-22	97.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4FFCE@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	GO:0008150,GO:0040007	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
TLS3_k127_2105756_23	1463856.JOHY01000030_gene2809	6.464e-24	113.0	2EM92@1|root,33EY7@2|Bacteria,2GS4K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2105756_9	313589.JNB_09394	4.966e-114	382.0	COG0157@1|root,COG0157@2|Bacteria,2I2IP@201174|Actinobacteria,4FEMG@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
TLS3_k127_2105756_1	1380370.JIBA01000019_gene1101	5.965e-232	750.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,4FE43@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS3_k127_2105756_6	1172188.KB911826_gene100	5.255e-154	493.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4FF43@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
TLS3_k127_2105756_10	367299.JOEE01000001_gene1988	2.003e-113	375.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4FE81@85021|Intrasporangiaceae	201174|Actinobacteria	S	Coenzyme F420-dependent NADP oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
TLS3_k127_2105756_26	653386.HMPREF0975_02548	1.203e-17	90.0	COG1476@1|root,COG1476@2|Bacteria,2GQIU@201174|Actinobacteria,4D6BY@85005|Actinomycetales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
TLS3_k127_2105756_16	367299.JOEE01000001_gene1987	1.181e-94	325.0	COG1565@1|root,COG1565@2|Bacteria,2GKIU@201174|Actinobacteria,4FEH5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
TLS3_k127_2105756_22	1386089.N865_09325	1.742e-29	124.0	COG4978@1|root,COG4978@2|Bacteria,2IS9W@201174|Actinobacteria,4FHRK@85021|Intrasporangiaceae	201174|Actinobacteria	KT	family transcriptional regulator	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
TLS3_k127_2105756_3	367299.JOEE01000001_gene1986	7.191e-189	594.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4FEEA@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS3_k127_2105756_24	367299.JOEE01000001_gene1986	3.646e-22	95.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4FEEA@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS3_k127_2105756_13	1122622.ATWJ01000008_gene2698	4.667e-99	325.0	COG2227@1|root,COG2227@2|Bacteria,2I2JZ@201174|Actinobacteria,4FH4X@85021|Intrasporangiaceae	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_2105756_21	313589.JNB_09449	3.758e-30	132.0	2DRQG@1|root,33CMQ@2|Bacteria,2HXM1@201174|Actinobacteria,4FHBU@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3180
TLS3_k127_2105756_12	1193181.BN10_1210030	4.609e-102	340.0	COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,2H3G6@201174|Actinobacteria,4FF6S@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
TLS3_k127_2105756_14	313589.JNB_09459	1.418e-98	342.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,4FF3G@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS3_k127_2105756_17	1385518.N798_13620	1.133e-92	311.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4FE4X@85021|Intrasporangiaceae	201174|Actinobacteria	H	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
TLS3_k127_2105756_0	1385520.N802_10570	0.0	1114.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4FECS@85021|Intrasporangiaceae	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
TLS3_k127_2105756_15	1193181.BN10_70005	1.443e-95	321.0	COG0037@1|root,COG0634@1|root,COG0037@2|Bacteria,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4FESD@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
TLS3_k127_2105756_8	1385518.N798_13595	8.066e-123	404.0	COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,4FFMR@85021|Intrasporangiaceae	201174|Actinobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0008150,GO:0040007	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
TLS3_k127_2105756_7	313589.JNB_09499	1.51e-148	481.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4FE4C@85021|Intrasporangiaceae	201174|Actinobacteria	S	Coenzyme F420 biosynthesis-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS3_k127_2105756_18	1089455.MOPEL_074_00770	1.449e-91	319.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4F718@85018|Dermatophilaceae	201174|Actinobacteria	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
TLS3_k127_2105756_11	1385519.N801_13175	1.123e-111	364.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4FFC9@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3628	Pyrophosphatase
TLS3_k127_2105756_4	1380386.JIAW01000027_gene7116	1.456e-179	572.0	COG2235@1|root,COG2235@2|Bacteria,2GJTR@201174|Actinobacteria,23653@1762|Mycobacteriaceae	201174|Actinobacteria	E	Arginine deiminase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
TLS3_k127_2105756_20	1137271.AZUM01000002_gene2452	2.461e-42	161.0	COG2076@1|root,COG2076@2|Bacteria,2IQND@201174|Actinobacteria,4E5FX@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM small multidrug resistance protein	sugE	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
TLS3_k127_2105756_2	367299.JOEE01000001_gene1922	2.127e-200	640.0	COG0596@1|root,COG0596@2|Bacteria,2GJYS@201174|Actinobacteria,4FF86@85021|Intrasporangiaceae	201174|Actinobacteria	S	proteinase	slpD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS3_k127_2105756_5	1385520.N802_10695	1.674e-169	548.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria,4FFBG@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA polymerase III subunit delta	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
TLS3_k127_2105756_19	1385521.N803_10220	1.182e-89	302.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4FG27@85021|Intrasporangiaceae	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,MFS_3,Thymidylate_kin
TLS3_k127_2121379_0	1386089.N865_21390	5.395e-264	818.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4FFDM@85021|Intrasporangiaceae	201174|Actinobacteria	L	Helicase	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
TLS3_k127_2121379_17	1385518.N798_00015	6.232e-23	106.0	2EGCD@1|root,33A46@2|Bacteria,2GWRN@201174|Actinobacteria,4FI05@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190,DUF4352
TLS3_k127_2121379_7	367299.JOEE01000006_gene840	3.456e-143	482.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4FEHD@85021|Intrasporangiaceae	201174|Actinobacteria	E	Hydroxymethylglutaryl-CoA lyase	hmgL	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
TLS3_k127_2121379_4	1385521.N803_04105	1.53e-184	606.0	COG2378@1|root,COG2378@2|Bacteria,2GURQ@201174|Actinobacteria,4FEKN@85021|Intrasporangiaceae	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
TLS3_k127_2121379_13	1385519.N801_03350	2.867e-50	197.0	COG1278@1|root,COG1278@2|Bacteria,2IKXN@201174|Actinobacteria,4FGX5@85021|Intrasporangiaceae	201174|Actinobacteria	K	Cold-shock protein	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS3_k127_2121379_10	1386089.N865_21365	1.593e-109	361.0	28NWB@1|root,2ZBU7@2|Bacteria,2GJ74@201174|Actinobacteria,4FENM@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3027)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3027
TLS3_k127_2121379_16	1380370.JIBA01000019_gene972	1.911e-23	102.0	2DSCZ@1|root,33FKC@2|Bacteria,2GR4J@201174|Actinobacteria,4FHV6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2530)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2530
TLS3_k127_2121379_1	1385520.N802_06390	5.704e-239	748.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4FE4H@85021|Intrasporangiaceae	201174|Actinobacteria	S	permease	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
TLS3_k127_2121379_15	367299.JOEE01000006_gene846	1.161e-36	144.0	COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria,4FGV1@85021|Intrasporangiaceae	201174|Actinobacteria	K	MarR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_2121379_5	1385521.N803_04145	1.031e-175	563.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4FF3R@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	pimH	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS3_k127_2121379_18	367299.JOEE01000006_gene795	1.907e-10	70.0	28R15@1|root,2ZDFS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
TLS3_k127_2121379_14	863239.AFIZ01000032_gene1899	2.569e-38	156.0	COG2367@1|root,COG2367@2|Bacteria,2GJTM@201174|Actinobacteria,22MZV@1653|Corynebacteriaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2121379_3	710696.Intca_0746	1.528e-197	628.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4FEJI@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
TLS3_k127_2121379_2	1380370.JIBA01000019_gene963	9.387e-203	637.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria,4FEBE@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the citrate synthase family	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_2121379_12	1385519.N801_04505	9.291e-75	257.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria,4FEM1@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2607	PNP_phzG_C,Putative_PNPOx
TLS3_k127_2121379_6	477641.MODMU_2285	1.322e-170	552.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4EU5I@85013|Frankiales	201174|Actinobacteria	C	Iron-containing alcohol dehydrogenase	adhfe	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
TLS3_k127_2121379_11	2045.KR76_22110	2.291e-107	354.0	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4DPFM@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	sdh	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_2121379_8	1385519.N801_11740	2.399e-118	387.0	COG0385@1|root,COG0385@2|Bacteria,2GMAM@201174|Actinobacteria,4FFME@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bile acid sodium symporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
TLS3_k127_2121379_9	1077144.AGFF01000023_gene1023	1.206e-111	363.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS3_k127_2292509_7	935839.JAGJ01000002_gene913	2.76e-114	383.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
TLS3_k127_2292509_9	446466.Cfla_0403	9.403e-80	271.0	COG0637@1|root,COG0637@2|Bacteria,2GNX0@201174|Actinobacteria,4F2F1@85016|Cellulomonadaceae	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	3.1.3.23	ko:K19270	-	-	-	-	ko00000,ko01000	-	-	-	HAD_2
TLS3_k127_2292509_8	1122138.AQUZ01000001_gene1480	1.984e-97	342.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,4DS0U@85009|Propionibacteriales	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
TLS3_k127_2292509_19	526225.Gobs_1413	1.579e-28	129.0	COG0640@1|root,COG0640@2|Bacteria,2I2TF@201174|Actinobacteria,4EXH1@85013|Frankiales	201174|Actinobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
TLS3_k127_2292509_22	526225.Gobs_1414	4.475e-12	73.0	2DFH7@1|root,2ZRUE@2|Bacteria,2GSP8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2292509_5	935839.JAGJ01000032_gene38	3.19e-141	454.0	COG5361@1|root,COG5361@2|Bacteria,2GKTA@201174|Actinobacteria,4F5DW@85017|Promicromonosporaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
TLS3_k127_2292509_13	1449044.JMLE01000009_gene3154	1.143e-56	206.0	COG0346@1|root,COG0346@2|Bacteria,2IHQQ@201174|Actinobacteria,1W9EV@1268|Micrococcaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_2292509_18	1312954.KI914878_gene1376	2.064e-35	136.0	COG0640@1|root,COG0640@2|Bacteria,2GNW2@201174|Actinobacteria,1WADX@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_2292509_14	1385519.N801_05275	4.423e-53	190.0	2CNK3@1|root,32SH9@2|Bacteria,2IRH1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
TLS3_k127_2292509_10	288705.RSal33209_1726	1.086e-79	274.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,1W9B3@1268|Micrococcaceae	201174|Actinobacteria	P	Carbonic anhydrase	mtcA1	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008270,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS3_k127_2292509_20	1229203.KI301992_gene2602	2.759e-24	116.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
TLS3_k127_2292509_0	313589.JNB_16801	0.0	1087.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4FEJS@85021|Intrasporangiaceae	201174|Actinobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
TLS3_k127_2292509_15	1386089.N865_13575	1.225e-51	187.0	2EH65@1|root,33AY1@2|Bacteria,2I75W@201174|Actinobacteria,4FH3V@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1876)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1876,DUF1918
TLS3_k127_2292509_1	743718.Isova_0153	7.497e-190	601.0	COG4222@1|root,COG4222@2|Bacteria,2GJN8@201174|Actinobacteria,4F3JV@85017|Promicromonosporaceae	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_2292509_12	1395587.P364_0112480	6.873e-67	256.0	COG1136@1|root,COG1136@2|Bacteria,1TQU8@1239|Firmicutes,4HG9D@91061|Bacilli,26QM7@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_2292509_2	446465.Bfae_15640	2.867e-175	578.0	COG0577@1|root,COG0577@2|Bacteria,2IB3W@201174|Actinobacteria,4FCR3@85020|Dermabacteraceae	201174|Actinobacteria	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
TLS3_k127_2292509_21	1133849.O3I_040545	6.01e-17	93.0	2EQSP@1|root,33ICH@2|Bacteria,2GWX9@201174|Actinobacteria,4G2K3@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2292509_4	443218.AS9A_0987	3.537e-149	508.0	COG2267@1|root,COG2267@2|Bacteria,2I9JC@201174|Actinobacteria	201174|Actinobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
TLS3_k127_2292509_16	2002.JOEQ01000009_gene6564	3.495e-45	180.0	COG4585@1|root,COG4585@2|Bacteria,2IA1U@201174|Actinobacteria,4EHCI@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS3_k127_2292509_11	452652.KSE_63120	1.057e-71	254.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,2M55S@2063|Kitasatospora	201174|Actinobacteria	K	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_2292509_3	1075090.GOAMR_21_00340	1.023e-151	486.0	COG2130@1|root,COG2130@2|Bacteria,2GKR8@201174|Actinobacteria,4GAR6@85026|Gordoniaceae	201174|Actinobacteria	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
TLS3_k127_2292509_6	1122622.ATWJ01000008_gene2607	1.019e-127	430.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,4FJXN@85021|Intrasporangiaceae	201174|Actinobacteria	IT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
TLS3_k127_2292509_17	1122622.ATWJ01000009_gene3137	6.775e-45	166.0	COG1012@1|root,COG1012@2|Bacteria,2GMNB@201174|Actinobacteria,4FJ2A@85021|Intrasporangiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_2299803_6	1385521.N803_03310	6.809e-27	110.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria,4FFMA@85021|Intrasporangiaceae	201174|Actinobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
TLS3_k127_2299803_5	1385520.N802_07860	1.013e-40	152.0	COG3860@1|root,COG3860@2|Bacteria,2HXJ0@201174|Actinobacteria,4FH44@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087
TLS3_k127_2299803_2	1385519.N801_05680	7.404e-118	385.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4FES4@85021|Intrasporangiaceae	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
TLS3_k127_2299803_1	1193181.BN10_130082	1.303e-305	951.0	COG0488@1|root,COG0488@2|Bacteria,2GMUD@201174|Actinobacteria,4FE37@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS3_k127_2299803_4	1385520.N802_07845	2.052e-55	208.0	2FFPB@1|root,347KP@2|Bacteria,2IQ2W@201174|Actinobacteria,4FGWC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2993)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2993
TLS3_k127_2299803_3	367299.JOEE01000007_gene23	4.087e-105	347.0	COG0708@1|root,COG0708@2|Bacteria,2GKIS@201174|Actinobacteria,4FEP7@85021|Intrasporangiaceae	201174|Actinobacteria	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS3_k127_2299803_0	313589.JNB_08064	0.0	1024.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,2GKK1@201174|Actinobacteria,4FEA5@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3372
TLS3_k127_239215_16	1172188.KB911826_gene55	1.159e-150	480.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4FEM0@85021|Intrasporangiaceae	201174|Actinobacteria	BQ	acetoin utilization protein	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS3_k127_239215_46	367299.JOEE01000001_gene2011	2.465e-26	108.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4FHPI@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
TLS3_k127_239215_48	1043205.AFYF01000061_gene2884	9.564e-09	56.0	2DFJU@1|root,2ZS54@2|Bacteria,2HEE6@201174|Actinobacteria	201174|Actinobacteria	S	Mitochondrial domain of unknown function (DUF1713)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1713
TLS3_k127_239215_23	367299.JOEE01000001_gene2013	6.214e-136	439.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4FF9R@85021|Intrasporangiaceae	201174|Actinobacteria	GM	epimerase	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0501	Epimerase
TLS3_k127_239215_19	710696.Intca_0651	7.716e-141	462.0	COG0204@1|root,COG0204@2|Bacteria,2GJKH@201174|Actinobacteria,4FG6Z@85021|Intrasporangiaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS3_k127_239215_44	1385518.N798_13760	2.936e-30	121.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4FHMF@85021|Intrasporangiaceae	201174|Actinobacteria	O	Glutaredoxin-like domain (DUF836)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
TLS3_k127_239215_35	1385520.N802_09030	1.176e-81	277.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4FF0I@85021|Intrasporangiaceae	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
TLS3_k127_239215_18	1385518.N798_13770	4.672e-146	475.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4FF7M@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
TLS3_k127_239215_28	1172188.KB911826_gene44	4.148e-117	390.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4FE32@85021|Intrasporangiaceae	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
TLS3_k127_239215_5	367299.JOEE01000001_gene2019	9.498e-225	709.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4FF2G@85021|Intrasporangiaceae	201174|Actinobacteria	H	Uroporphyrin-III C-methyltransferase	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
TLS3_k127_239215_15	1385519.N801_04745	2.216e-151	488.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4FEW1@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
TLS3_k127_239215_40	1193181.BN10_240002	5.169e-45	185.0	COG1846@1|root,COG1846@2|Bacteria,2GP6A@201174|Actinobacteria,4FH18@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_239215_6	1385519.N801_04760	2.029e-221	698.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FF4C@85021|Intrasporangiaceae	201174|Actinobacteria	H	Glutamate-1-semialdehyde aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_239215_37	188626.HMPREF0321_0172	9.5e-69	255.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria,1ZVW0@145357|Dermacoccaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS3_k127_239215_38	367299.JOEE01000001_gene2027	7.016e-58	216.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4FG0N@85021|Intrasporangiaceae	201174|Actinobacteria	CO	Thiol disulfide interchange protein	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS3_k127_239215_34	1385519.N801_04775	1.995e-84	290.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4FF34@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome c biogenesis protein	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
TLS3_k127_239215_10	1385519.N801_04780	3.939e-195	621.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4FE3H@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome C	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
TLS3_k127_239215_27	1385518.N798_13825	1.527e-121	404.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4FEHY@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome c biogenesis	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
TLS3_k127_239215_47	1193181.BN10_470006	8.29e-20	96.0	2EHXC@1|root,33BNY@2|Bacteria,2GSC6@201174|Actinobacteria,4FHR5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4229
TLS3_k127_239215_45	1385518.N798_13845	5.111e-27	113.0	2EGDD@1|root,33A58@2|Bacteria,2GR3X@201174|Actinobacteria,4FHNU@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
TLS3_k127_239215_31	367299.JOEE01000001_gene2032	1.015e-105	357.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4FF0S@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
TLS3_k127_239215_33	1386089.N865_19925	7.477e-88	315.0	COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4FF7B@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	menE	GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007	4.2.1.113,6.2.1.26	ko:K01911,ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030,R04031	RC00004,RC00014,RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_239215_36	710696.Intca_1799	4.729e-76	276.0	28NT3@1|root,2ZBRV@2|Bacteria,2IIC3@201174|Actinobacteria,4FJBY@85021|Intrasporangiaceae	201174|Actinobacteria	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
TLS3_k127_239215_13	1385519.N801_04815	7.392e-182	582.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4FE8Y@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS3_k127_239215_22	1385519.N801_04830	6.286e-138	448.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4FEF4@85021|Intrasporangiaceae	201174|Actinobacteria	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	GO:0008150,GO:0040007	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0553	MR_MLE_C
TLS3_k127_239215_11	367299.JOEE01000001_gene2041	8.554e-195	650.0	COG1249@1|root,COG1249@2|Bacteria,2GNSR@201174|Actinobacteria,4FFPD@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	mtr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0010126,GO:0016137,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050627,GO:0050660,GO:0050661,GO:0050662,GO:0051186,GO:0055114,GO:0070402,GO:0071704,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901657	1.8.1.15	ko:K17883	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_239215_42	1385521.N803_10690	2.317e-35	157.0	COG1075@1|root,COG1075@2|Bacteria,2IHFB@201174|Actinobacteria,4FHYQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	ADC,Lipase_3,PGAP1
TLS3_k127_239215_17	1193181.BN10_470029	1.243e-150	497.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4FFK6@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
TLS3_k127_239215_12	367299.JOEE01000001_gene2046	1.432e-184	589.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4FEWQ@85021|Intrasporangiaceae	201174|Actinobacteria	HQ	Isochorismate synthase	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
TLS3_k127_239215_25	367299.JOEE01000001_gene2047	6.66e-122	400.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4FEFS@85021|Intrasporangiaceae	201174|Actinobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
TLS3_k127_239215_39	1210046.B277_04537	1.156e-56	201.0	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4FGQA@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
TLS3_k127_239215_26	591157.SSLG_03965	1.032e-121	405.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
TLS3_k127_239215_3	367299.JOEE01000001_gene2051	4.135e-248	784.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4FEXH@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
TLS3_k127_239215_24	367299.JOEE01000001_gene2052	9.668e-129	422.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4FFA6@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADH dehydrogenase subunit E	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
TLS3_k127_239215_4	1121385.AQXW01000004_gene2145	6.023e-247	768.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
TLS3_k127_239215_0	367299.JOEE01000001_gene2054	0.0	1058.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4FF98@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the transfer of electrons from NADH to quinone	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
TLS3_k127_239215_9	1210046.B277_04572	1.942e-210	670.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4FEYT@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	NADHdh
TLS3_k127_239215_30	1380370.JIBA01000019_gene1015	9.358e-106	346.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4FFGF@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
TLS3_k127_239215_32	367299.JOEE01000001_gene2057	1.328e-88	314.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4FFRB@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
TLS3_k127_239215_41	1121385.AQXW01000004_gene2140	1.798e-44	162.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
TLS3_k127_239215_2	367299.JOEE01000001_gene2059	1.345e-289	904.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4FEJ4@85021|Intrasporangiaceae	201174|Actinobacteria	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
TLS3_k127_239215_8	367299.JOEE01000001_gene2060	2.61e-218	689.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4FFDF@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS3_k127_239215_7	1385518.N798_10200	1.127e-218	689.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4FF3X@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
TLS3_k127_239215_21	367299.JOEE01000001_gene2062	3.3e-139	450.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4FE3E@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS3_k127_239215_20	367299.JOEE01000001_gene2064	1.709e-139	458.0	COG3616@1|root,COG3616@2|Bacteria,2GJMB@201174|Actinobacteria,4FEF3@85021|Intrasporangiaceae	201174|Actinobacteria	E	Alanine racemase	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
TLS3_k127_239215_29	1385520.N802_08645	2.412e-107	355.0	COG2962@1|root,COG2962@2|Bacteria,2GKCP@201174|Actinobacteria,4FERD@85021|Intrasporangiaceae	201174|Actinobacteria	S	EamA-like transporter family	rarD	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
TLS3_k127_239215_14	367299.JOEE01000001_gene2072	6.371e-180	569.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4FEAR@85021|Intrasporangiaceae	201174|Actinobacteria	C	2-oxoacid ferredoxin oxidoreductase subunit beta	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
TLS3_k127_239215_1	1193181.BN10_460016	4e-323	997.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4FEQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	ferredoxin oxidoreductase	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
TLS3_k127_239215_43	367299.JOEE01000006_gene854	5.565e-31	125.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria,4FJZS@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS3_k127_2395951_7	1193181.BN10_1590013	1.589e-53	189.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4FH32@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
TLS3_k127_2395951_10	367299.JOEE01000004_gene1183	3.015e-34	138.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4FHNM@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
TLS3_k127_2395951_3	313589.JNB_19823	2.773e-169	550.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4FFWJ@85021|Intrasporangiaceae	201174|Actinobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
TLS3_k127_2395951_6	1386089.N865_10205	4.508e-99	339.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4FEJX@85021|Intrasporangiaceae	201174|Actinobacteria	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
TLS3_k127_2395951_9	1043493.BBLU01000002_gene1863	1.038e-38	149.0	2EJRI@1|root,32U8K@2|Bacteria,2IT18@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_2395951_5	313589.JNB_19833	1.557e-123	404.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4FE45@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_2395951_8	1385519.N801_13395	1.109e-39	157.0	COG0739@1|root,COG0739@2|Bacteria,2IQ64@201174|Actinobacteria,4FHBN@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_2395951_2	1385518.N798_04305	8.025e-192	606.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4FEEH@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase	dapC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.6.1.1,2.6.1.17	ko:K00812,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv0858c	Aminotran_1_2
TLS3_k127_2395951_1	1043205.AFYF01000056_gene2611	4.642e-243	765.0	COG1132@1|root,COG1132@2|Bacteria,2GJAP@201174|Actinobacteria,4FF0Q@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS3_k127_2395951_0	1122622.ATWJ01000007_gene1646	1.376e-268	857.0	COG1132@1|root,COG1132@2|Bacteria,2GJ8B@201174|Actinobacteria,4FEWF@85021|Intrasporangiaceae	201174|Actinobacteria	V	Multidrug ABC transporter ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
TLS3_k127_2395951_4	1193181.BN10_1590023	4.819e-164	532.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FJ6S@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS3_k127_2395951_11	110319.CF8_2840	1.508e-20	93.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4DP30@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
TLS3_k127_2442365_4	1193181.BN10_520070	1.097e-07	53.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4FGS6@85021|Intrasporangiaceae	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
TLS3_k127_2442365_1	1385518.N798_12725	5.557e-96	321.0	COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria,4FFA9@85021|Intrasporangiaceae	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
TLS3_k127_2442365_0	1385521.N803_08215	3.884e-117	387.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FFQG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
TLS3_k127_2442365_2	196162.Noca_1329	4.133e-68	240.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
TLS3_k127_2442365_3	367299.JOEE01000008_gene635	5.105e-25	109.0	COG0310@1|root,COG0310@2|Bacteria,2GRUA@201174|Actinobacteria,4FHVG@85021|Intrasporangiaceae	201174|Actinobacteria	P	PDGLE domain	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	PDGLE
TLS3_k127_2446627_2	452652.KSE_16270	8.523e-69	242.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,2M42V@2063|Kitasatospora	201174|Actinobacteria	M	Bacterial sugar transferase	epsL	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
TLS3_k127_2446627_1	1123023.JIAI01000007_gene1669	3.916e-146	491.0	COG0399@1|root,COG0399@2|Bacteria,2IEA4@201174|Actinobacteria,4E994@85010|Pseudonocardiales	201174|Actinobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS3_k127_2446627_0	882083.SacmaDRAFT_1583	5.768e-185	598.0	COG1086@1|root,COG1086@2|Bacteria,2GIXM@201174|Actinobacteria,4E5SG@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Polysaccharide biosynthesis protein	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
TLS3_k127_2446627_3	882083.SacmaDRAFT_1585	3.738e-57	223.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4E2DG@85010|Pseudonocardiales	201174|Actinobacteria	DM	biosynthesis protein	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA,MipZ,ParA,Wzz
TLS3_k127_2560206_3	1193181.BN10_680022	6.869e-65	223.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FFXF@85021|Intrasporangiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
TLS3_k127_2560206_4	1385521.N803_00855	2.995e-22	98.0	2EFU9@1|root,339KE@2|Bacteria,2GQJW@201174|Actinobacteria,4FHWC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3046)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3046
TLS3_k127_2560206_2	1122182.KB903833_gene5401	5.53e-86	321.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
TLS3_k127_2560206_1	1184609.KILIM_026_00510	3.942e-158	511.0	COG1893@1|root,COG1893@2|Bacteria,2I5YZ@201174|Actinobacteria	201174|Actinobacteria	H	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	odh	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	NAD_Gly3P_dh_N,Octopine_DH
TLS3_k127_2560206_0	313589.JNB_05240	0.0	1814.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4FEQ8@85021|Intrasporangiaceae	201174|Actinobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
TLS3_k127_2573165_0	1385518.N798_11705	0.0	1119.0	COG2319@1|root,COG3391@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3391@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4FE3I@85021|Intrasporangiaceae	201174|Actinobacteria	K	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,PD40,Trans_reg_C,WD40
TLS3_k127_2573165_2	1122622.ATWJ01000009_gene3373	1.925e-98	325.0	COG0431@1|root,COG0431@2|Bacteria,2GMA7@201174|Actinobacteria,4FET3@85021|Intrasporangiaceae	201174|Actinobacteria	S	NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
TLS3_k127_2573165_14	1172188.KB911827_gene4199	3.315e-24	109.0	2EASN@1|root,334UM@2|Bacteria,2IPUJ@201174|Actinobacteria,4FH8A@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2573165_3	1386089.N865_08590	3.46e-85	287.0	COG2304@1|root,COG2304@2|Bacteria,2IFH7@201174|Actinobacteria,4FFEQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
TLS3_k127_2573165_12	1089455.MOPEL_080_00020	2.998e-30	121.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
TLS3_k127_2573165_17	479434.Sthe_3241	2.016e-09	71.0	COG2197@1|root,COG2197@2|Bacteria,2G80G@200795|Chloroflexi,27XVP@189775|Thermomicrobia	189775|Thermomicrobia	T	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_2573165_15	103733.JNYO01000031_gene1535	5.925e-21	109.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4E0IZ@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,HTH_31,NB-ARC,TPR_12,Trans_reg_C
TLS3_k127_2573165_6	1386089.N865_09820	2.687e-59	213.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4FGG1@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peroxiredoxin	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
TLS3_k127_2573165_11	1122622.ATWJ01000002_gene819	7.886e-31	128.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4FHX9@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_2573165_10	706439.HMPREF9057_03133	1.235e-33	136.0	COG1917@1|root,COG1917@2|Bacteria,2IR2V@201174|Actinobacteria,4D86M@85005|Actinomycetales	201174|Actinobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2
TLS3_k127_2573165_7	1089455.MOPEL_007_00550	1.725e-56	204.0	2E5UY@1|root,330J5@2|Bacteria,2GRRC@201174|Actinobacteria	201174|Actinobacteria	S	Golgi phosphoprotein 3 (GPP34)	-	-	-	-	-	-	-	-	-	-	-	-	GPP34
TLS3_k127_2573165_8	479434.Sthe_2946	5.28e-53	199.0	arCOG10456@1|root,2ZA6T@2|Bacteria,2G90M@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2573165_5	1032480.MLP_16330	1.738e-76	287.0	COG4585@1|root,COG4585@2|Bacteria,2H6D7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS3_k127_2573165_4	1032480.MLP_16340	3.95e-83	287.0	COG2197@1|root,COG2197@2|Bacteria,2GIXB@201174|Actinobacteria	201174|Actinobacteria	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_2573165_1	710696.Intca_3538	0.0	1087.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4FIMQ@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	pacL2	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS3_k127_2573165_9	543632.JOJL01000028_gene106	1.685e-36	156.0	COG1917@1|root,COG1917@2|Bacteria,2IQ74@201174|Actinobacteria,4DJMB@85008|Micromonosporales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2604613_23	1184609.KILIM_077_00150	4.236e-72	252.0	COG0747@1|root,COG0747@2|Bacteria,2GMMG@201174|Actinobacteria	201174|Actinobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS3_k127_2604613_12	367299.JOEE01000004_gene1052	1.123e-119	402.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4FE7D@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG1104 Cysteine sulfinate desulfinase cysteine desulfurase	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
TLS3_k127_2604613_7	367299.JOEE01000004_gene1053	2.769e-176	575.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4FE6F@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
TLS3_k127_2604613_8	1385519.N801_13770	2.142e-174	551.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4FG5R@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS3_k127_2604613_31	1122622.ATWJ01000013_gene208	6.897e-41	155.0	COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria,4FJCM@85021|Intrasporangiaceae	201174|Actinobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
TLS3_k127_2604613_10	1121385.AQXW01000004_gene2793	2.052e-134	460.0	COG1741@1|root,COG1741@2|Bacteria,2GM9P@201174|Actinobacteria,1ZVUX@145357|Dermacoccaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
TLS3_k127_2604613_13	367299.JOEE01000004_gene1060	8.811e-118	398.0	COG0620@1|root,COG0620@2|Bacteria,2GMPS@201174|Actinobacteria,4FF5N@85021|Intrasporangiaceae	201174|Actinobacteria	E	Methionine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
TLS3_k127_2604613_14	367299.JOEE01000004_gene1061	7.513e-111	368.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4FF67@85021|Intrasporangiaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_2604613_9	1193181.BN10_540073	1.226e-155	503.0	COG1680@1|root,COG1680@2|Bacteria,2GK3A@201174|Actinobacteria,4FFEB@85021|Intrasporangiaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_2604613_0	1120958.AULD01000006_gene164	0.0	1209.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4FMNB@85023|Microbacteriaceae	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
TLS3_k127_2604613_22	367299.JOEE01000004_gene1073	1.747e-73	257.0	COG2860@1|root,COG2860@2|Bacteria,2GMI4@201174|Actinobacteria,4FGW3@85021|Intrasporangiaceae	201174|Actinobacteria	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
TLS3_k127_2604613_26	1089455.MOPEL_029_01520	7.981e-54	198.0	COG0243@1|root,COG0243@2|Bacteria,2GJ62@201174|Actinobacteria,4F6E6@85018|Dermatophilaceae	201174|Actinobacteria	C	molybdopterin cofactor binding	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS3_k127_2604613_30	1193181.BN10_570028	3.625e-49	184.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PA14
TLS3_k127_2604613_32	367299.JOEE01000004_gene1074	3.09e-38	150.0	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,4FH6M@85021|Intrasporangiaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
TLS3_k127_2604613_3	367299.JOEE01000004_gene1075	2.876e-272	848.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4FFVV@85021|Intrasporangiaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
TLS3_k127_2604613_5	367299.JOEE01000004_gene1076	1.365e-265	850.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4FE8G@85021|Intrasporangiaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
TLS3_k127_2604613_25	1385518.N798_17220	1.165e-57	208.0	COG5403@1|root,COG5403@2|Bacteria,2IKKK@201174|Actinobacteria,4FGNX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
TLS3_k127_2604613_17	710696.Intca_2369	1.607e-94	319.0	COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,4FEUT@85021|Intrasporangiaceae	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
TLS3_k127_2604613_18	136273.GY22_07885	1.063e-83	287.0	COG0596@1|root,COG0596@2|Bacteria,2GJDM@201174|Actinobacteria,1WCD2@1268|Micrococcaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_2604613_19	1385519.N801_03260	8.195e-82	274.0	COG5592@1|root,COG5592@2|Bacteria,2IGW0@201174|Actinobacteria,4FG2N@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS3_k127_2604613_24	1385519.N801_03255	2.546e-65	231.0	2B9CE@1|root,322Q4@2|Bacteria,2IKT2@201174|Actinobacteria,4FGMR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
TLS3_k127_2604613_28	1385519.N801_03250	2.937e-52	188.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria,4FGYU@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS3_k127_2604613_27	1385519.N801_03245	2.461e-52	198.0	COG0711@1|root,COG0711@2|Bacteria,2IQQZ@201174|Actinobacteria,4FHI1@85021|Intrasporangiaceae	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2604613_21	1385519.N801_13890	1.202e-74	257.0	COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria,4FFZK@85021|Intrasporangiaceae	201174|Actinobacteria	T	Phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS3_k127_2604613_1	1193181.BN10_1360002	0.0	1104.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4FESM@85021|Intrasporangiaceae	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
TLS3_k127_2604613_16	367299.JOEE01000004_gene1087	3.541e-100	338.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FEKY@85021|Intrasporangiaceae	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_2604613_15	367299.JOEE01000004_gene1088	4.965e-108	368.0	2BWH2@1|root,2Z89R@2|Bacteria,2GMNW@201174|Actinobacteria,4FFB7@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS3_k127_2604613_2	367299.JOEE01000004_gene1091	0.0	1021.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4FFIE@85021|Intrasporangiaceae	201174|Actinobacteria	E	Acetolactate synthase	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_2604613_20	367299.JOEE01000004_gene1092	7.171e-79	270.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4FFYA@85021|Intrasporangiaceae	201174|Actinobacteria	E	acetolactate synthase	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
TLS3_k127_2604613_6	1385518.N798_17265	2.215e-198	622.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4FEUM@85021|Intrasporangiaceae	201174|Actinobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
TLS3_k127_2604613_33	62928.azo3001	4.848e-06	55.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,2VMW2@28216|Betaproteobacteria,2KVZH@206389|Rhodocyclales	206389|Rhodocyclales	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_2604613_29	367299.JOEE01000004_gene1094	7.476e-50	190.0	COG0586@1|root,COG0586@2|Bacteria,2GSDF@201174|Actinobacteria,4FHBR@85021|Intrasporangiaceae	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_2604613_4	1385518.N798_17275	2.732e-270	841.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4FE7W@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
TLS3_k127_2604613_11	1386089.N865_13985	8.529e-124	406.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4FEDG@85021|Intrasporangiaceae	201174|Actinobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS3_k127_2632761_10	1385518.N798_09340	1.259e-98	324.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4FE5U@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
TLS3_k127_2632761_13	710696.Intca_1441	1.484e-79	269.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4FGCY@85021|Intrasporangiaceae	201174|Actinobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
TLS3_k127_2632761_21	1210046.B277_04105	3.184e-12	72.0	COG1388@1|root,COG1388@2|Bacteria,2GWI9@201174|Actinobacteria,4FHMA@85021|Intrasporangiaceae	201174|Actinobacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
TLS3_k127_2632761_8	1386089.N865_01705	2.034e-108	364.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4FETR@85021|Intrasporangiaceae	201174|Actinobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
TLS3_k127_2632761_1	1211815.CBYP010000015_gene2680	9.638e-317	983.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4ERFZ@85013|Frankiales	201174|Actinobacteria	P	E1-E2 ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_2632761_14	110319.CF8_3202	1.513e-78	271.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria,4DQE0@85009|Propionibacteriales	201174|Actinobacteria	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS3_k127_2632761_2	1385519.N801_08350	2.402e-232	727.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4FG5M@85021|Intrasporangiaceae	201174|Actinobacteria	P	Cation transport protein	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
TLS3_k127_2632761_23	391596.PBAL39_00732	9.145e-06	59.0	COG1225@1|root,COG1225@2|Bacteria,4P08Q@976|Bacteroidetes,1J0GJ@117747|Sphingobacteriia	976|Bacteroidetes	O	Domain of unknown function (DUF4369)	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF4369,Thioredoxin_8
TLS3_k127_2632761_15	479431.Namu_1999	1.723e-69	249.0	COG1073@1|root,COG1073@2|Bacteria,2IPVI@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2632761_11	1292020.H483_0114200	3.841e-96	320.0	2A651@1|root,30UXH@2|Bacteria,2IERM@201174|Actinobacteria	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS3_k127_2632761_16	1110697.NCAST_12_00260	1.196e-66	238.0	COG1309@1|root,COG1309@2|Bacteria,2IMHK@201174|Actinobacteria,4G4MW@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_2632761_12	935839.JAGJ01000029_gene9	2.015e-80	286.0	COG2247@1|root,COG2931@1|root,COG2247@2|Bacteria,COG2931@2|Bacteria,2HFCX@201174|Actinobacteria,4F5WU@85017|Promicromonosporaceae	201174|Actinobacteria	Q	cell wall binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2632761_20	1193181.BN10_930018	1.807e-33	134.0	2A5AS@1|root,30U04@2|Bacteria,2H1K6@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4259
TLS3_k127_2632761_19	1385521.N803_05920	1.046e-42	166.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	ylcC	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
TLS3_k127_2632761_18	1123024.AUII01000009_gene2037	1.881e-47	192.0	COG0500@1|root,COG2226@2|Bacteria,2I36Q@201174|Actinobacteria,4E5FR@85010|Pseudonocardiales	201174|Actinobacteria	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_2632761_9	1210046.B277_04115	5.65e-104	349.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4FEKG@85021|Intrasporangiaceae	201174|Actinobacteria	K	NAD-dependent	cobB	-	-	-	-	-	-	-	-	-	-	-	SIR2
TLS3_k127_2632761_7	585531.HMPREF0063_12113	6.664e-125	410.0	COG0530@1|root,COG0530@2|Bacteria,2GJR3@201174|Actinobacteria,4DUB5@85009|Propionibacteriales	201174|Actinobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
TLS3_k127_2632761_4	1193181.BN10_300015	1.607e-206	655.0	COG2985@1|root,COG2985@2|Bacteria,2GKDW@201174|Actinobacteria,4FIFK@85021|Intrasporangiaceae	201174|Actinobacteria	U	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
TLS3_k127_2632761_6	367299.JOEE01000004_gene1294	1.289e-140	451.0	COG0583@1|root,COG0583@2|Bacteria,2GKT0@201174|Actinobacteria,4FFNX@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_2632761_5	1122939.ATUD01000001_gene199	2.118e-198	625.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4CPEP@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_2632761_3	1210046.B277_04125	1.281e-207	674.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4FEQ6@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
TLS3_k127_2632761_17	1172188.KB911824_gene3358	1.183e-55	204.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4FGC5@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG1555 DNA uptake protein and related DNA-binding	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
TLS3_k127_2632761_0	1193181.BN10_930006	0.0	1500.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4FEMM@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS3_k127_2642555_13	1385519.N801_01985	1.254e-94	317.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4FE9G@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS3_k127_2642555_22	1385518.N798_02260	1.133e-09	64.0	2BNYH@1|root,32HNJ@2|Bacteria,2H5FQ@201174|Actinobacteria,4FJ39@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2642555_1	367299.JOEE01000002_gene2289	2.378e-250	776.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4FFAU@85021|Intrasporangiaceae	201174|Actinobacteria	E	in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor	aspC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.6.1.1,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	iNJ661.Rv0337c	Aminotran_1_2
TLS3_k127_2642555_2	1210046.B277_01094	3.861e-221	707.0	COG1960@1|root,COG1960@2|Bacteria,2GJ4X@201174|Actinobacteria,4FEBJ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyl-CoA oxidase	acx	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_2642555_6	367299.JOEE01000002_gene2287	1.678e-171	547.0	COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,4FE3P@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glucose sorbosone	gcd	-	-	-	-	-	-	-	-	-	-	-	GSDH
TLS3_k127_2642555_14	1385518.N798_02220	1.892e-79	273.0	2A4DI@1|root,30SZC@2|Bacteria,2GJJM@201174|Actinobacteria,4FESI@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2642555_12	1385520.N802_05815	8.212e-96	324.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4FGWX@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_2642555_4	367299.JOEE01000002_gene2285	5.164e-186	597.0	COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria,4FFB2@85021|Intrasporangiaceae	201174|Actinobacteria	G	transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
TLS3_k127_2642555_3	1033730.CAHG01000010_gene2521	6.649e-187	601.0	COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,4DNM8@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.11,4.1.1.25,4.1.2.27	ko:K01634,ko:K18933	ko00350,ko00410,ko00600,ko00680,ko00770,ko01100,ko01110,ko04071,map00350,map00410,map00600,map00680,map00770,map01100,map01110,map04071	M00100	R00489,R00736,R02464,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
TLS3_k127_2642555_16	1096756.ATKN01000001_gene2084	8.511e-45	179.0	COG1522@1|root,COG1522@2|Bacteria,2GMSR@201174|Actinobacteria,1W9AV@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS3_k127_2642555_8	1194165.CAJF01000027_gene378	3.314e-148	482.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4FMTB@85023|Microbacteriaceae	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_2642555_10	110319.CF8_3491	2.864e-127	419.0	COG0477@1|root,COG2814@2|Bacteria,2H0CW@201174|Actinobacteria,4DN0M@85009|Propionibacteriales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_2642555_5	1386089.N865_03580	6.45e-186	601.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4FEVA@85021|Intrasporangiaceae	201174|Actinobacteria	C	FAD-linked oxidase	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
TLS3_k127_2642555_0	1385521.N803_15640	2.839e-272	870.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FEX6@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	AMP-binding protein	fadD5	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_2642555_20	367299.JOEE01000002_gene2281	1.326e-19	102.0	2FEQY@1|root,346Q4@2|Bacteria,2GSR9@201174|Actinobacteria,4FH9B@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2642555_15	1210046.B277_00360	1.339e-57	211.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,2GIWB@201174|Actinobacteria,4FH6S@85021|Intrasporangiaceae	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,NLPC_P60
TLS3_k127_2642555_19	1385521.N803_12160	2.005e-25	109.0	COG1917@1|root,COG1917@2|Bacteria,2HMQA@201174|Actinobacteria,4FI2T@85021|Intrasporangiaceae	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2642555_21	367299.JOEE01000003_gene2821	1.312e-17	86.0	COG0746@1|root,COG0746@2|Bacteria,2I62G@201174|Actinobacteria,4FHPV@85021|Intrasporangiaceae	201174|Actinobacteria	H	molybdenum cofactor guanylyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2642555_17	1035308.AQYY01000001_gene1415	2.474e-40	156.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS3_k127_2642555_9	367299.JOEE01000003_gene2822	5.031e-133	431.0	COG2181@1|root,COG2181@2|Bacteria,2GJVI@201174|Actinobacteria,4FFNE@85021|Intrasporangiaceae	201174|Actinobacteria	C	Nitrate reductase	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
TLS3_k127_2642555_11	367299.JOEE01000003_gene2823	3.985e-102	341.0	COG2180@1|root,COG2180@2|Bacteria,2IAQV@201174|Actinobacteria,4FF4E@85021|Intrasporangiaceae	201174|Actinobacteria	C	Nitrate reductase	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
TLS3_k127_2642555_18	1122609.AUGT01000005_gene1707	1.425e-28	117.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4DPZ0@85009|Propionibacteriales	201174|Actinobacteria	C	Respiratory nitrate reductase beta C-terminal	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
TLS3_k127_2642555_7	1043205.AFYF01000021_gene828	3.773e-152	482.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4FFT8@85021|Intrasporangiaceae	201174|Actinobacteria	C	the beta subunit is an iron sulfur cluster containing electron transfer subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
TLS3_k127_2646625_12	1043205.AFYF01000087_gene1150	1.759e-45	173.0	COG0454@1|root,COG0456@2|Bacteria,2I8DS@201174|Actinobacteria	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_2646625_17	1210046.B277_07820	2.907e-10	72.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4FE3X@85021|Intrasporangiaceae	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS3_k127_2646625_2	367299.JOEE01000002_gene2447	2.179e-225	710.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4FFPC@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
TLS3_k127_2646625_0	1035308.AQYY01000001_gene3249	1.575e-309	960.0	COG2015@1|root,COG2015@2|Bacteria,1TR7Q@1239|Firmicutes,248SN@186801|Clostridia,260W7@186807|Peptococcaceae	186801|Clostridia	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
TLS3_k127_2646625_3	367299.JOEE01000002_gene2444	1.199e-158	512.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4FEAU@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS3_k127_2646625_10	367299.JOEE01000002_gene2443	7.66e-94	327.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FEH7@85021|Intrasporangiaceae	201174|Actinobacteria	T	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_2646625_5	1193181.BN10_1240001	3.227e-129	420.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4FEGG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS3_k127_2646625_4	367299.JOEE01000002_gene2441	6.91e-132	443.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4FF50@85021|Intrasporangiaceae	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS3_k127_2646625_6	1385521.N803_14975	2.382e-121	394.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4FF6B@85021|Intrasporangiaceae	201174|Actinobacteria	S	HAD family hydrolase	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS3_k127_2646625_8	1385521.N803_14980	4.283e-109	364.0	2DBB1@1|root,2Z854@2|Bacteria,2GNBN@201174|Actinobacteria,4FEXB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of Unknown Function (DUF1206)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1206
TLS3_k127_2646625_15	1095767.CAHD01000041_gene1437	5.73e-22	101.0	COG0239@1|root,COG0239@2|Bacteria,2IKWG@201174|Actinobacteria	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS3_k127_2646625_16	593907.Celgi_3013	9.274e-20	100.0	COG0239@1|root,COG0239@2|Bacteria	2|Bacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
TLS3_k127_2646625_11	1454010.JEOE01000005_gene1723	1.067e-56	203.0	COG0589@1|root,COG0589@2|Bacteria,2GUPR@201174|Actinobacteria,4F2S1@85016|Cellulomonadaceae	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_2646625_14	1386089.N865_18580	1.371e-33	139.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4FEH1@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS3_k127_2646625_9	1385518.N798_03540	9.549e-105	346.0	COG0566@1|root,COG0566@2|Bacteria,2GP9S@201174|Actinobacteria,4FEGY@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
TLS3_k127_2646625_7	367299.JOEE01000002_gene2429	3.309e-112	365.0	COG0346@1|root,COG0346@2|Bacteria,2I5X0@201174|Actinobacteria,4FFUT@85021|Intrasporangiaceae	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
TLS3_k127_2646625_1	1121017.AUFG01000002_gene2785	1.731e-250	799.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4FEV4@85021|Intrasporangiaceae	201174|Actinobacteria	P	COG2217 Cation transport ATPase	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_2646625_13	367299.JOEE01000002_gene2427	1.693e-38	150.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4FHET@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS3_k127_265361_4	1193181.BN10_580004	1.527e-36	139.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4FF3A@85021|Intrasporangiaceae	201174|Actinobacteria	S	Extradiol ring-cleavage dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
TLS3_k127_265361_2	1385518.N798_13390	1.505e-206	654.0	COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria,4FFPS@85021|Intrasporangiaceae	201174|Actinobacteria	J	SAM-dependent methyltransferase	rsmC	-	-	-	-	-	-	-	-	-	-	-	MTS
TLS3_k127_265361_0	1193181.BN10_580014	0.0	1167.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4FE4Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS3_k127_265361_5	367299.JOEE01000001_gene1894	1.391e-32	131.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4FH4C@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_265361_3	313589.JNB_14713	7.728e-111	364.0	COG0300@1|root,COG0300@2|Bacteria,2GKAJ@201174|Actinobacteria,4FI7N@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_265361_1	1385519.N801_03880	6.007e-213	683.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4FE8S@85021|Intrasporangiaceae	201174|Actinobacteria	L	RNA helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS3_k127_2682638_4	1210046.B277_12226	5.075e-82	282.0	COG3268@1|root,COG3268@2|Bacteria,2GNGH@201174|Actinobacteria,4FFCY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Enoyl reductase	LYS1	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030312,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K12445	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	Sacchrp_dh_NADP
TLS3_k127_2682638_2	1385518.N798_01830	7.214e-138	451.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4FG57@85021|Intrasporangiaceae	201174|Actinobacteria	G	Nucleotidyl transferase	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS3_k127_2682638_3	1380370.JIBA01000015_gene220	2.09e-113	378.0	COG2850@1|root,COG2850@2|Bacteria,2GMR2@201174|Actinobacteria,4FF39@85021|Intrasporangiaceae	201174|Actinobacteria	S	A domain family that is part of the cupin metalloenzyme superfamily.	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
TLS3_k127_2682638_7	367299.JOEE01000001_gene1653	2.889e-56	209.0	COG4759@1|root,COG4759@2|Bacteria,2GRSQ@201174|Actinobacteria,4FG5P@85021|Intrasporangiaceae	201174|Actinobacteria	O	Sucrase/ferredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Suc_Fer-like
TLS3_k127_2682638_0	1122611.KB903985_gene3748	2.084e-320	1019.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4EH64@85012|Streptosporangiales	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
TLS3_k127_2682638_6	367299.JOEE01000001_gene1664	1.335e-69	241.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4FGNC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2587)	bpa	GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369	-	-	-	-	-	-	-	-	-	-	DUF2587
TLS3_k127_2682638_10	1552758.NC00_04320	1.775e-15	89.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RYRW@1236|Gammaproteobacteria,1X4V6@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
TLS3_k127_2682638_9	1122614.JHZF01000013_gene2950	6.653e-24	108.0	2B7RY@1|root,320Y6@2|Bacteria,1RIW4@1224|Proteobacteria,2UAY4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2
TLS3_k127_2682638_1	1172188.KB911827_gene4246	1.122e-188	600.0	COG0786@1|root,COG0786@2|Bacteria,2IAKR@201174|Actinobacteria,4FIYN@85021|Intrasporangiaceae	201174|Actinobacteria	E	glutamate:sodium symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2682638_5	446471.Xcel_1387	2.068e-71	256.0	COG0628@1|root,COG0628@2|Bacteria,2IM8N@201174|Actinobacteria	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_2682638_8	1035308.AQYY01000001_gene2149	1.243e-26	109.0	COG0471@1|root,COG0471@2|Bacteria	2|Bacteria	P	metal ion transport	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
TLS3_k127_2698338_2	1043205.AFYF01000076_gene1663	2.938e-233	727.0	COG0477@1|root,COG0477@2|Bacteria,2HC9X@201174|Actinobacteria,4FK05@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Sugar (and other) transporter	nanT	-	-	ko:K03290,ko:K08178,ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1,2.A.1.12	-	-	MFS_1,Sugar_tr
TLS3_k127_2698338_11	1385520.N802_05770	1.056e-135	454.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4FFJC@85021|Intrasporangiaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
TLS3_k127_2698338_10	935866.JAER01000030_gene4303	1.947e-136	440.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4DPD1@85009|Propionibacteriales	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS3_k127_2698338_20	367299.JOEE01000001_gene2105	4.302e-84	284.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4FEWC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the UPF0234 family	trpF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
TLS3_k127_2698338_23	1449069.JMLO01000002_gene4587	3.929e-79	275.0	COG0596@1|root,COG0596@2|Bacteria,2GJDM@201174|Actinobacteria,4FUPB@85025|Nocardiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_2698338_26	208444.JNYY01000028_gene2445	2.457e-47	179.0	COG0824@1|root,COG0824@2|Bacteria,2IJV6@201174|Actinobacteria,4E3ZU@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
TLS3_k127_2698338_13	1415755.JQLV01000002_gene689	1.047e-127	425.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,1RMGW@1236|Gammaproteobacteria,1XRHK@135619|Oceanospirillales	135619|Oceanospirillales	F	Uracil permease	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
TLS3_k127_2698338_8	367299.JOEE01000001_gene2114	2.258e-148	474.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4FFW7@85021|Intrasporangiaceae	201174|Actinobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS3_k127_2698338_9	1385519.N801_05180	7.625e-138	458.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4FE5F@85021|Intrasporangiaceae	201174|Actinobacteria	S	Von Willebrand factor	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_2698338_4	367299.JOEE01000001_gene2116	4.819e-183	581.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4FEEE@85021|Intrasporangiaceae	201174|Actinobacteria	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	xdhC	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS3_k127_2698338_7	1380370.JIBA01000011_gene3318	7.401e-149	488.0	COG3173@1|root,COG3173@2|Bacteria,2GZAV@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_2698338_19	1043205.AFYF01000076_gene1659	3.025e-85	286.0	COG0174@1|root,COG0174@2|Bacteria,2IFHQ@201174|Actinobacteria,4FGEV@85021|Intrasporangiaceae	201174|Actinobacteria	E	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
TLS3_k127_2698338_21	313589.JNB_08714	1.422e-82	281.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4FGCF@85021|Intrasporangiaceae	201174|Actinobacteria	C	carbon monoxide dehydrogenase	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS3_k127_2698338_0	367299.JOEE01000001_gene2118	0.0	1441.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FE7V@85021|Intrasporangiaceae	201174|Actinobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_2698338_14	1193181.BN10_460053	1.397e-124	419.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4FEK9@85021|Intrasporangiaceae	201174|Actinobacteria	C	COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs	cutM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS3_k127_2698338_18	367299.JOEE01000001_gene2120	2.769e-88	297.0	COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4FEDB@85021|Intrasporangiaceae	201174|Actinobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	-	-	-	-	-	-	-	-	-	COXG
TLS3_k127_2698338_28	710696.Intca_0590	8.422e-36	142.0	COG2149@1|root,COG2149@2|Bacteria,2GQU9@201174|Actinobacteria,4FHFI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
TLS3_k127_2698338_30	1122622.ATWJ01000009_gene3335	4.411e-21	101.0	2B3QZ@1|root,31WEI@2|Bacteria,2HXVV@201174|Actinobacteria,4FI00@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF202
TLS3_k127_2698338_16	367299.JOEE01000001_gene2124	7.384e-93	312.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4FF7T@85021|Intrasporangiaceae	201174|Actinobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	cseB	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_2698338_1	1386089.N865_10140	1.004e-264	849.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4FJYV@85021|Intrasporangiaceae	201174|Actinobacteria	T	Domain of unknown function (DUF4173)	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_2698338_24	367299.JOEE01000001_gene2135	2.63e-61	214.0	COG2030@1|root,COG2030@2|Bacteria,2GMVC@201174|Actinobacteria,4FGKA@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the UPF0336 family	hadA	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
TLS3_k127_2698338_25	1385519.N801_05345	3.901e-56	200.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4FGSM@85021|Intrasporangiaceae	201174|Actinobacteria	I	dehydratase	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
TLS3_k127_2698338_5	710696.Intca_2794	3.065e-157	510.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4FEF2@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS3_k127_2698338_6	1385518.N798_05735	7.64e-156	501.0	COG1816@1|root,COG1816@2|Bacteria,2GKJP@201174|Actinobacteria,4FEG3@85021|Intrasporangiaceae	201174|Actinobacteria	F	adenosine deaminase	add	GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
TLS3_k127_2698338_27	367299.JOEE01000001_gene2140	6.177e-40	153.0	2E6NT@1|root,32UXC@2|Bacteria,2I895@201174|Actinobacteria,4FGRH@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2698338_3	367299.JOEE01000001_gene2141	1.466e-197	627.0	COG1167@1|root,COG1167@2|Bacteria,2GKVK@201174|Actinobacteria,4FF5H@85021|Intrasporangiaceae	201174|Actinobacteria	EK	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	aspT	-	-	-	-	-	-	-	-	-	-	-	Aminotran_MocR
TLS3_k127_2698338_29	1385518.N798_05760	6.665e-23	100.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria,4FHHX@85021|Intrasporangiaceae	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
TLS3_k127_2698338_15	367299.JOEE01000001_gene2144	9.902e-107	354.0	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,4FF79@85021|Intrasporangiaceae	201174|Actinobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
TLS3_k127_2698338_22	1380370.JIBA01000015_gene204	1.033e-81	274.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4FGDC@85021|Intrasporangiaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
TLS3_k127_2698338_12	1385520.N802_08210	1.101e-129	421.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4FEH9@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
TLS3_k127_2698338_17	1385518.N798_05840	2.7e-88	295.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4FEG8@85021|Intrasporangiaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
TLS3_k127_2769888_3	710696.Intca_2589	4.594e-119	388.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4FF03@85021|Intrasporangiaceae	201174|Actinobacteria	P	transporter	mgtE	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
TLS3_k127_2769888_6	1193181.BN10_1070039	3.677e-72	248.0	COG4420@1|root,COG4420@2|Bacteria,2GJRV@201174|Actinobacteria,4FGJR@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
TLS3_k127_2769888_0	1385518.N798_11585	7.807e-198	621.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4FEXA@85021|Intrasporangiaceae	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
TLS3_k127_2769888_8	1385519.N801_19155	1.496e-42	161.0	COG1826@1|root,COG1826@2|Bacteria,2IR0U@201174|Actinobacteria,4FHHW@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0008150,GO:0040007	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS3_k127_2769888_2	1385518.N798_11595	7.921e-136	450.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4FF22@85021|Intrasporangiaceae	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
TLS3_k127_2769888_5	1385521.N803_02930	8.032e-85	304.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4FEE8@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_2769888_4	1385519.N801_19175	3.297e-88	297.0	COG4122@1|root,COG4122@2|Bacteria,2GPEV@201174|Actinobacteria,4FFAX@85021|Intrasporangiaceae	201174|Actinobacteria	S	O-methyltransferase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
TLS3_k127_2769888_7	1193181.BN10_130004	2.234e-51	185.0	2CDCR@1|root,3434A@2|Bacteria,2IPYI@201174|Actinobacteria,4FGY7@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2769888_1	1385520.N802_07505	1.13e-165	537.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FIS1@85021|Intrasporangiaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS3_k127_2863238_15	1232429.CBLL010000149_gene1194	2.279e-98	330.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,1W7ZJ@1268|Micrococcaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS3_k127_2863238_21	1385518.N798_02305	1.212e-73	261.0	COG0300@1|root,COG0300@2|Bacteria,2I64P@201174|Actinobacteria,4FGB5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_2863238_14	313589.JNB_10924	3.529e-100	346.0	COG0508@1|root,COG0508@2|Bacteria,2I8Q8@201174|Actinobacteria,4FEUV@85021|Intrasporangiaceae	201174|Actinobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
TLS3_k127_2863238_26	592015.HMPREF1705_02038	6.627e-43	169.0	COG2423@1|root,COG2423@2|Bacteria,3TAM0@508458|Synergistetes	508458|Synergistetes	E	Ornithine cyclodeaminase mu-crystallin family	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
TLS3_k127_2863238_1	1386089.N865_04535	1.31e-257	799.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4FFWW@85021|Intrasporangiaceae	201174|Actinobacteria	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_2863238_20	33876.JNXY01000001_gene5661	5.002e-74	269.0	COG1171@1|root,COG1171@2|Bacteria,2H1VX@201174|Actinobacteria	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
TLS3_k127_2863238_7	1151122.AQYD01000007_gene1362	4.725e-138	452.0	COG1940@1|root,COG1940@2|Bacteria,2GNFJ@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,ROK
TLS3_k127_2863238_3	1177594.MIC448_280017	1.952e-204	643.0	COG1653@1|root,COG1653@2|Bacteria,2IAYI@201174|Actinobacteria,4FRED@85023|Microbacteriaceae	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8,TAT_signal
TLS3_k127_2863238_6	1177594.MIC448_280016	1.026e-140	455.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4FRK4@85023|Microbacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
TLS3_k127_2863238_8	1416752.AYME01000002_gene819	1.753e-136	441.0	COG0395@1|root,COG0395@2|Bacteria,2GNQW@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
TLS3_k127_2863238_0	979556.MTES_2158	2.023e-272	848.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4FN0T@85023|Microbacteriaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
TLS3_k127_2863238_23	367299.JOEE01000001_gene1568	3.406e-46	174.0	COG3467@1|root,COG3467@2|Bacteria,2I2V6@201174|Actinobacteria,4FHMZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
TLS3_k127_2863238_4	1043205.AFYF01000027_gene288	2.292e-197	632.0	COG3046@1|root,COG3046@2|Bacteria,2GMF6@201174|Actinobacteria,4FGQD@85021|Intrasporangiaceae	201174|Actinobacteria	S	Deoxyribodipyrimidine photo-lyase-related protein	cry1	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP,FAD_binding_7
TLS3_k127_2863238_17	1386089.N865_20100	5.541e-90	310.0	COG1073@1|root,COG1073@2|Bacteria,2IHUE@201174|Actinobacteria,4FFW2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
TLS3_k127_2863238_27	1122609.AUGT01000002_gene4075	1.413e-37	145.0	COG2388@1|root,COG2388@2|Bacteria,2GQNP@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
TLS3_k127_2863238_18	585531.HMPREF0063_12146	1.732e-83	282.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4DQIW@85009|Propionibacteriales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS3_k127_2863238_29	644283.Micau_3327	6.174e-28	118.0	2DNXR@1|root,32ZPP@2|Bacteria,2I2KW@201174|Actinobacteria,4DFBI@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
TLS3_k127_2863238_22	1298863.AUEP01000004_gene2137	2.655e-67	235.0	COG2364@1|root,COG2364@2|Bacteria,2GPBY@201174|Actinobacteria,4DUBE@85009|Propionibacteriales	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2863238_2	110319.CF8_3940	5.335e-222	697.0	COG3211@1|root,COG3211@2|Bacteria,2GJKE@201174|Actinobacteria,4DNUN@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
TLS3_k127_2863238_24	313589.JNB_16514	4.001e-46	168.0	COG1359@1|root,COG1359@2|Bacteria,2IQ6Y@201174|Actinobacteria,4FGZM@85021|Intrasporangiaceae	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS3_k127_2863238_11	1385520.N802_03860	1.668e-121	419.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,4FFCX@85021|Intrasporangiaceae	201174|Actinobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
TLS3_k127_2863238_9	1121017.AUFG01000016_gene2538	3.79e-132	428.0	COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,4FEU9@85021|Intrasporangiaceae	201174|Actinobacteria	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_2863238_25	1120958.AULD01000015_gene1380	1.075e-44	176.0	COG3871@1|root,COG3871@2|Bacteria,2IM6Z@201174|Actinobacteria,4FP93@85023|Microbacteriaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
TLS3_k127_2863238_19	367299.JOEE01000007_gene57	7.601e-75	258.0	COG3403@1|root,COG3403@2|Bacteria,2IBB2@201174|Actinobacteria,4FGP4@85021|Intrasporangiaceae	201174|Actinobacteria	S	YqcI/YcgG family	-	-	-	ko:K09190	-	-	-	-	ko00000	-	-	-	YqcI_YcgG
TLS3_k127_2863238_13	188626.HMPREF0321_2381	1.353e-106	351.0	COG3665@1|root,COG3665@2|Bacteria,2GKI6@201174|Actinobacteria	201174|Actinobacteria	S	TIGRFAM Urea carboxylase-associated protein 1	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
TLS3_k127_2863238_16	1172188.KB911820_gene2609	9.241e-91	302.0	COG0693@1|root,COG0693@2|Bacteria,2GMMW@201174|Actinobacteria,4FGE1@85021|Intrasporangiaceae	201174|Actinobacteria	S	DJ-1/PfpI family	yfkM	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
TLS3_k127_2863238_10	1089455.MOPEL_036_00160	2.926e-125	410.0	COG0053@1|root,COG0053@2|Bacteria,2GKPR@201174|Actinobacteria,4F7FH@85018|Dermatophilaceae	201174|Actinobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
TLS3_k127_2863238_28	1089455.MOPEL_036_00170	1.759e-31	131.0	COG0834@1|root,COG0834@2|Bacteria,2IQ78@201174|Actinobacteria,4F81N@85018|Dermatophilaceae	201174|Actinobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
TLS3_k127_2863238_12	1184609.KILIM_029_00320	1.279e-116	384.0	COG2706@1|root,COG2706@2|Bacteria,2HSX1@201174|Actinobacteria,4F7HM@85018|Dermatophilaceae	201174|Actinobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
TLS3_k127_2863238_5	1265313.HRUBRA_00224	3.495e-152	492.0	28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,1RP4W@1236|Gammaproteobacteria,1J6EN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_291822_6	1123023.JIAI01000028_gene4508	6.013e-30	121.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,4E5PE@85010|Pseudonocardiales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
TLS3_k127_291822_2	43354.JOIJ01000004_gene3706	6.57e-111	384.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4DYE1@85010|Pseudonocardiales	201174|Actinobacteria	P	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
TLS3_k127_291822_1	1385518.N798_00030	3.113e-113	400.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4FE6S@85021|Intrasporangiaceae	201174|Actinobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_291822_0	1385518.N798_00035	4.555e-155	517.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4FFK1@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_291822_4	313589.JNB_16644	6.656e-64	244.0	COG5373@1|root,COG5373@2|Bacteria,2GJII@201174|Actinobacteria,4FFEE@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
TLS3_k127_291822_3	1193181.BN10_1400004	1.069e-85	290.0	COG1051@1|root,COG1051@2|Bacteria,2I5X3@201174|Actinobacteria,4FEFN@85021|Intrasporangiaceae	201174|Actinobacteria	F	Protein of unknown function (DUF4031)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4031,NUDIX
TLS3_k127_291822_5	1385519.N801_08135	4.797e-30	135.0	COG4842@1|root,COG4842@2|Bacteria,2GQI8@201174|Actinobacteria,4FHIC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the WXG100 family	-	-	-	-	-	-	-	-	-	-	-	-	WXG100
TLS3_k127_2931762_8	1385520.N802_10915	7.568e-11	72.0	COG4963@1|root,COG4963@2|Bacteria	2|Bacteria	-	-	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TadZ_N
TLS3_k127_2931762_3	1210046.B277_04884	7.507e-97	339.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4FF72@85021|Intrasporangiaceae	201174|Actinobacteria	U	type II secretion system protein E	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS3_k127_2931762_7	313589.JNB_09764	2.653e-12	77.0	COG4965@1|root,COG4965@2|Bacteria,2H1G9@201174|Actinobacteria,4FI36@85021|Intrasporangiaceae	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS3_k127_2931762_5	1386089.N865_09470	2.873e-20	100.0	COG2064@1|root,COG2064@2|Bacteria,2HXIB@201174|Actinobacteria,4FH0N@85021|Intrasporangiaceae	201174|Actinobacteria	NU	Secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
TLS3_k127_2931762_10	1123251.ATWM01000007_gene2353	1.514e-07	57.0	2EHCF@1|root,33B4A@2|Bacteria,2HXWD@201174|Actinobacteria,4FI32@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4244
TLS3_k127_2931762_9	1121385.AQXW01000004_gene2324	6.697e-08	63.0	2DRBM@1|root,33B4F@2|Bacteria	2|Bacteria	S	TIGRFAM helicase secretion neighborhood TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS3_k127_2931762_6	1385518.N798_13360	1.887e-19	99.0	2B3GG@1|root,31W5F@2|Bacteria,2IN4W@201174|Actinobacteria,4FH2I@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2931762_1	1385518.N798_13365	0.0	1058.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4FE8S@85021|Intrasporangiaceae	201174|Actinobacteria	L	RNA helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
TLS3_k127_2931762_2	1385521.N803_12415	8.244e-110	371.0	COG0300@1|root,COG0300@2|Bacteria,2GKAJ@201174|Actinobacteria,4FI7N@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_2931762_4	367299.JOEE01000001_gene1894	3.864e-29	120.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4FH4C@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
TLS3_k127_2931762_0	1193181.BN10_580014	0.0	1206.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4FE4Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
TLS3_k127_2979712_9	1151061.CAJY01000038_gene3458	1.824e-06	53.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_2979712_0	1193181.BN10_800013	0.0	1417.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4FENT@85021|Intrasporangiaceae	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
TLS3_k127_2979712_7	367299.JOEE01000001_gene1724	7.312e-60	221.0	2DQVM@1|root,338Y0@2|Bacteria,2ISKA@201174|Actinobacteria,4FGKE@85021|Intrasporangiaceae	201174|Actinobacteria	S	LppX_LprAFG lipoprotein	-	-	-	ko:K14954	ko05152,map05152	-	-	-	ko00000,ko00001	-	-	-	LppX_LprAFG
TLS3_k127_2979712_1	1385520.N802_12460	8.82e-204	661.0	COG0477@1|root,COG2814@2|Bacteria,2I2DZ@201174|Actinobacteria,4FEXX@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_2979712_6	1385518.N798_01335	6.357e-63	228.0	COG2267@1|root,COG2267@2|Bacteria,2GJSU@201174|Actinobacteria,4FGJ2@85021|Intrasporangiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS3_k127_2979712_2	1385519.N801_07005	3.698e-132	425.0	COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4FFA0@85021|Intrasporangiaceae	201174|Actinobacteria	L	exodeoxyribonuclease III	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
TLS3_k127_2979712_8	585531.HMPREF0063_11520	2.42e-45	169.0	COG0607@1|root,COG0607@2|Bacteria,2GR81@201174|Actinobacteria,4DVZT@85009|Propionibacteriales	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_2979712_5	1304865.JAGF01000001_gene828	1.352e-66	234.0	COG2120@1|root,COG2120@2|Bacteria,2IJ0C@201174|Actinobacteria	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS3_k127_2979712_3	888050.HMPREF9004_1842	3.754e-89	305.0	COG1275@1|root,COG1275@2|Bacteria,2IA9G@201174|Actinobacteria	201174|Actinobacteria	P	C4-dicarboxylate transporter malic acid transport protein	-	-	-	ko:K03304	-	-	-	-	ko00000,ko02000	2.A.16.1	-	-	SLAC1
TLS3_k127_2979712_4	1386089.N865_05605	5.563e-80	275.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4FFCH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_299008_19	1385520.N802_17720	7.351e-41	154.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4FGZE@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
TLS3_k127_299008_15	1122622.ATWJ01000010_gene1272	5.288e-51	195.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4FGE9@85021|Intrasporangiaceae	201174|Actinobacteria	G	phosphoglycerate mutase	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS3_k127_299008_6	1385518.N798_11010	9.381e-151	486.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4FEBV@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_299008_20	1184607.AUCHE_05_00390	8.817e-18	89.0	2ECBY@1|root,336AB@2|Bacteria,2GXKR@201174|Actinobacteria,4F74C@85018|Dermatophilaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_299008_21	1193181.BN10_560080	3.315e-17	85.0	2EGVE@1|root,33AMN@2|Bacteria,2HXWQ@201174|Actinobacteria,4FI6K@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_299008_0	367299.JOEE01000008_gene647	1.023e-216	684.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4FE9H@85021|Intrasporangiaceae	201174|Actinobacteria	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_299008_17	1123251.ATWM01000004_gene2007	7.143e-48	175.0	COG0589@1|root,COG0589@2|Bacteria,2IR3G@201174|Actinobacteria,4FGQB@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_299008_3	367299.JOEE01000002_gene2321	3.951e-186	584.0	COG0208@1|root,COG0208@2|Bacteria,2GKGZ@201174|Actinobacteria,4FEC5@85021|Intrasporangiaceae	201174|Actinobacteria	F	acyl-ACP desaturase	-	-	1.14.19.11,1.14.19.2,1.14.19.26	ko:K03921	ko00061,ko01040,ko01212,map00061,map01040,map01212	-	R03370,R08161,R11108,R11109	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase_2
TLS3_k127_299008_10	1172188.KB911823_gene496	2e-100	333.0	COG1718@1|root,COG1718@2|Bacteria,2GKX1@201174|Actinobacteria,4FEY6@85021|Intrasporangiaceae	201174|Actinobacteria	DT	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_299008_18	1385520.N802_17640	3.001e-47	174.0	2CP0Z@1|root,32SI8@2|Bacteria,2IHXV@201174|Actinobacteria,4FHAW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3037
TLS3_k127_299008_8	367299.JOEE01000005_gene3633	3.286e-128	415.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,4FF53@85021|Intrasporangiaceae	201174|Actinobacteria	J	RRNA methyltransferase	spoU2	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
TLS3_k127_299008_13	367299.JOEE01000005_gene3632	5.489e-59	214.0	COG0730@1|root,COG0730@2|Bacteria,2IIY7@201174|Actinobacteria,4FGSZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_299008_11	1043205.AFYF01000075_gene2021	1.526e-80	275.0	COG0730@1|root,COG0730@2|Bacteria,2GJCC@201174|Actinobacteria,4FE5R@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_299008_4	1193181.BN10_1080045	1.53e-172	553.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4FFBS@85021|Intrasporangiaceae	201174|Actinobacteria	O	prohibitin homologues	hflK	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7
TLS3_k127_299008_14	367299.JOEE01000005_gene3627	3.169e-53	194.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,4FH7Y@85021|Intrasporangiaceae	201174|Actinobacteria	OU	COG1585 Membrane protein implicated in regulation of membrane protease activity	nfeD	-	-	-	-	-	-	-	-	-	-	-	NfeD
TLS3_k127_299008_7	1385518.N798_15015	1.609e-135	435.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4FFS4@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter, ATP-binding protein	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
TLS3_k127_299008_16	1210046.B277_09722	5.138e-49	189.0	2B34P@1|root,31VSE@2|Bacteria,2HX46@201174|Actinobacteria,4FE3V@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_299008_2	1380370.JIBA01000013_gene1493	5.733e-208	652.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4FE4I@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase family 1	glgA	-	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_299008_1	1385519.N801_11665	7.482e-210	682.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4FEM7@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
TLS3_k127_299008_5	313589.JNB_03230	1.528e-158	509.0	COG0560@1|root,COG3830@1|root,COG0560@2|Bacteria,COG3830@2|Bacteria,2GJDH@201174|Actinobacteria,4FFIF@85021|Intrasporangiaceae	201174|Actinobacteria	E	phosphoserine phosphatase	serB	GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	iNJ661.Rv3042c	ACT_6,HAD
TLS3_k127_299008_9	1385520.N802_17570	1.06e-120	398.0	COG4242@1|root,COG4242@2|Bacteria,2I93U@201174|Actinobacteria,4FEKB@85021|Intrasporangiaceae	201174|Actinobacteria	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
TLS3_k127_299008_12	1385521.N803_08355	9.487e-75	252.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,2GN0U@201174|Actinobacteria,4FESF@85021|Intrasporangiaceae	201174|Actinobacteria	HJM	Belongs to the MurCDEF family	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,Mur_ligase_C,Mur_ligase_M,RimK
TLS3_k127_2991597_1	1385520.N802_00700	1.834e-108	372.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	ko:K01932	-	-	-	-	ko00000,ko01000	-	-	-	DUF4132,Glyco_transf_4,Glycos_transf_1,HEAT_2,LRV
TLS3_k127_2991597_5	1385520.N802_00695	3.742e-34	143.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS3_k127_2991597_6	937777.Deipe_2229	3.124e-25	123.0	COG0398@1|root,COG0398@2|Bacteria	2|Bacteria	M	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
TLS3_k127_2991597_3	1032480.MLP_36630	1.746e-69	252.0	COG3535@1|root,COG3535@2|Bacteria,2HJF5@201174|Actinobacteria,4DSA5@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
TLS3_k127_2991597_0	1032480.MLP_36640	3.918e-123	439.0	COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
TLS3_k127_2991597_2	1032480.MLP_36650	3.508e-93	323.0	2EQU0@1|root,33IDQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_2991597_4	1032480.MLP_36660	7.108e-65	232.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	AurF,Fer4_19,Ferritin-like,zf-CDGSH
TLS3_k127_3002816_5	530564.Psta_1213	6.583e-70	254.0	COG4932@1|root,COG4932@2|Bacteria,2IZVN@203682|Planctomycetes	203682|Planctomycetes	M	Protein of unknown function (DUF3494)	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DUF3494
TLS3_k127_3002816_1	1121877.JQKF01000090_gene1770	2.1e-139	456.0	COG1215@1|root,COG1215@2|Bacteria,2I5R7@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
TLS3_k127_3002816_0	710696.Intca_3295	7.164e-151	505.0	COG0381@1|root,COG0381@2|Bacteria,2GJWS@201174|Actinobacteria,4FG1P@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS3_k127_3002816_10	1146883.BLASA_1468	3.004e-27	120.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	sgaR	-	-	ko:K02479,ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
TLS3_k127_3002816_6	1385518.N798_03625	8.508e-63	228.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4FGSS@85021|Intrasporangiaceae	201174|Actinobacteria	M	Sortase family	srtB	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
TLS3_k127_3002816_13	593907.Celgi_0026	2.844e-12	67.0	2EHSF@1|root,33BI6@2|Bacteria,2HY51@201174|Actinobacteria,4F30J@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3002816_11	1043205.AFYF01000092_gene1136	4.371e-20	95.0	2F7X2@1|root,340AZ@2|Bacteria,2IS8B@201174|Actinobacteria,4FJAD@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3002816_3	1179773.BN6_49420	1.317e-119	391.0	COG0842@1|root,COG0842@2|Bacteria,2GIVW@201174|Actinobacteria,4E29M@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS3_k127_3002816_2	1429046.RR21198_2053	5.044e-125	405.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FV76@85025|Nocardiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_3002816_8	1121019.AUMN01000001_gene612	1.124e-48	177.0	COG4817@1|root,COG4817@2|Bacteria,2HUHS@201174|Actinobacteria,1WBMY@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1048)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1048
TLS3_k127_3002816_7	479432.Sros_8856	1.622e-53	189.0	COG1695@1|root,COG1695@2|Bacteria,2IM8U@201174|Actinobacteria,4EPD2@85012|Streptosporangiales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
TLS3_k127_3002816_9	324057.Pjdr2_2896	4.108e-29	131.0	COG0500@1|root,COG2226@2|Bacteria,1UYID@1239|Firmicutes,4HAJE@91061|Bacilli,26UBK@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_3002816_4	47839.CCAU010000004_gene946	4.869e-91	323.0	2B6PU@1|root,31ZNJ@2|Bacteria,2H2DG@201174|Actinobacteria,23DDB@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3002816_14	1385520.N802_00700	3.602e-10	70.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	ko:K01932	-	-	-	-	ko00000,ko01000	-	-	-	DUF4132,Glyco_transf_4,Glycos_transf_1,HEAT_2,LRV
TLS3_k127_3034085_6	1385519.N801_10185	4.559e-128	420.0	COG4850@1|root,COG4850@2|Bacteria,2GKPS@201174|Actinobacteria,4FEQ7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2183
TLS3_k127_3034085_4	1385518.N798_03135	9.253e-150	479.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4FFDQ@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS3_k127_3034085_12	1123251.ATWM01000001_gene579	2.809e-38	145.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4FH16@85021|Intrasporangiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_3034085_11	754252.PFREUD_19620	1.197e-63	239.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4DQTY@85009|Propionibacteriales	201174|Actinobacteria	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
TLS3_k127_3034085_8	196162.Noca_0392	2.85e-116	382.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria,4DPPI@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_3034085_13	196162.Noca_0393	1.176e-09	61.0	2BD8A@1|root,326WI@2|Bacteria,2HCG9@201174|Actinobacteria,4DW5C@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3034085_5	1385520.N802_08610	2.732e-139	453.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class v	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS3_k127_3034085_3	1278078.G419_01190	4.112e-163	525.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4FV3H@85025|Nocardiaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	tpdA	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_3034085_2	710696.Intca_0098	9.24e-166	537.0	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
TLS3_k127_3034085_10	1380370.JIBA01000010_gene2594	5.703e-77	270.0	COG3340@1|root,COG3340@2|Bacteria,2IGG2@201174|Actinobacteria,4FETH@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
TLS3_k127_3034085_1	1193181.BN10_470023	2.056e-195	616.0	COG0189@1|root,COG0189@2|Bacteria,2I75I@201174|Actinobacteria,4FEMX@85021|Intrasporangiaceae	201174|Actinobacteria	HJ	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2
TLS3_k127_3034085_7	110319.CF8_2185	1.08e-120	398.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,4DRD1@85009|Propionibacteriales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
TLS3_k127_3034085_0	305700.B447_16622	9.355e-317	992.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,2KUDV@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0474 Cation transport ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
TLS3_k127_3034085_9	1122622.ATWJ01000010_gene1431	9.057e-100	334.0	2F548@1|root,33XRC@2|Bacteria,2H5BG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3076560_1	1123251.ATWM01000009_gene2840	2.036e-313	977.0	COG1330@1|root,COG1330@2|Bacteria,2GNVB@201174|Actinobacteria,4FFTY@85021|Intrasporangiaceae	201174|Actinobacteria	L	Exodeoxyribonuclease V, gamma subunit	recC	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
TLS3_k127_3076560_0	1123251.ATWM01000009_gene2841	0.0	1512.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria,4FG59@85021|Intrasporangiaceae	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS3_k127_3076560_2	1122622.ATWJ01000013_gene94	1.812e-279	877.0	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria,4FFGW@85021|Intrasporangiaceae	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
TLS3_k127_3076560_4	1151061.CAJY01000037_gene1415	3.384e-73	250.0	COG3576@1|root,COG3576@2|Bacteria,2GKCF@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS3_k127_3076560_3	367299.JOEE01000006_gene854	2.63e-149	480.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria,4FJZS@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
TLS3_k127_3107678_13	710696.Intca_1789	7.739e-167	528.0	COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria,4FF3K@85021|Intrasporangiaceae	201174|Actinobacteria	E	Lysine 2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_3107678_16	1385521.N803_08020	4.725e-155	497.0	COG1063@1|root,COG1063@2|Bacteria,2GK3U@201174|Actinobacteria,4FE7C@85021|Intrasporangiaceae	201174|Actinobacteria	E	Zn-dependent alcohol dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_3107678_4	1193181.BN10_560038	8.182e-279	872.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria,4FFM6@85021|Intrasporangiaceae	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
TLS3_k127_3107678_20	1193181.BN10_560037	3.567e-136	445.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4FEVN@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
TLS3_k127_3107678_3	367299.JOEE01000008_gene587	1.885e-295	911.0	COG0274@1|root,COG0274@2|Bacteria,2GUM7@201174|Actinobacteria,4FETF@85021|Intrasporangiaceae	201174|Actinobacteria	F	Lysine 2,3-aminomutase	-	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
TLS3_k127_3107678_22	367299.JOEE01000008_gene586	4.8e-130	424.0	COG2185@1|root,COG2185@2|Bacteria,2HF50@201174|Actinobacteria,4FFS0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Lysine 5,6-aminomutase subunit beta	kamE	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
TLS3_k127_3107678_43	1193181.BN10_560033	7.89e-65	228.0	COG1607@1|root,COG1607@2|Bacteria,2IKM2@201174|Actinobacteria,4FGJW@85021|Intrasporangiaceae	201174|Actinobacteria	I	3-aminobutyryl-CoA ammonia lyase	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
TLS3_k127_3107678_15	1385518.N798_12500	1.904e-157	512.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria,4FEVP@85021|Intrasporangiaceae	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	GO:0000030,GO:0003674,GO:0003824,GO:0004582,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0070085,GO:0071704,GO:0071944,GO:0075136,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	iNJ661.Rv2051c	CN_hydrolase
TLS3_k127_3107678_27	1193181.BN10_560031	1.409e-113	378.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria,4FK0R@85021|Intrasporangiaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
TLS3_k127_3107678_56	710696.Intca_1796	8.467e-40	161.0	COG3030@1|root,COG3030@2|Bacteria,2IA8V@201174|Actinobacteria,4FHDA@85021|Intrasporangiaceae	201174|Actinobacteria	S	COG3030 Protein affecting phage T7 exclusion by the F plasmid	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
TLS3_k127_3107678_49	313589.JNB_02815	3.413e-57	200.0	2CNY9@1|root,32SI2@2|Bacteria,2IMK6@201174|Actinobacteria,4FGZR@85021|Intrasporangiaceae	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	GO:0001000,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0043167,GO:0043169,GO:0043175,GO:0045893,GO:0045935,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	RbpA
TLS3_k127_3107678_9	1210046.B277_01379	6.808e-213	671.0	COG2270@1|root,COG2270@2|Bacteria,2GJCW@201174|Actinobacteria	201174|Actinobacteria	S	Major facilitator Superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
TLS3_k127_3107678_32	1385518.N798_12470	1.078e-92	324.0	COG1876@1|root,COG1876@2|Bacteria,2II0R@201174|Actinobacteria,4FFZ5@85021|Intrasporangiaceae	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	VanY
TLS3_k127_3107678_61	1298863.AUEP01000006_gene3220	4.799e-33	136.0	COG3818@1|root,COG3818@2|Bacteria,2GRQA@201174|Actinobacteria,4DSBK@85009|Propionibacteriales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
TLS3_k127_3107678_62	1123251.ATWM01000002_gene281	2.799e-27	119.0	COG0629@1|root,COG0629@2|Bacteria,2GRPQ@201174|Actinobacteria,4FHVD@85021|Intrasporangiaceae	201174|Actinobacteria	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS3_k127_3107678_59	1043205.AFYF01000083_gene1859	2.03e-34	139.0	2BSGQ@1|root,32MIW@2|Bacteria,2H9NG@201174|Actinobacteria,4FJG4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3107678_41	1120936.KB907217_gene3678	3.692e-66	232.0	COG0645@1|root,COG0645@2|Bacteria,2I3JM@201174|Actinobacteria,4EIJV@85012|Streptosporangiales	201174|Actinobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
TLS3_k127_3107678_31	1385520.N802_09875	3.648e-94	314.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4FIPW@85021|Intrasporangiaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_3107678_17	1385520.N802_09870	1.603e-147	476.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4FH4A@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS3_k127_3107678_42	1122622.ATWJ01000009_gene3253	9.475e-66	244.0	2CC7D@1|root,33HWJ@2|Bacteria,2IP68@201174|Actinobacteria,4FJ2F@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3107678_7	1043205.AFYF01000026_gene343	9.169e-228	719.0	COG1757@1|root,COG1757@2|Bacteria,2GQ0Q@201174|Actinobacteria,4FIH2@85021|Intrasporangiaceae	201174|Actinobacteria	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
TLS3_k127_3107678_60	367299.JOEE01000010_gene3375	3.092e-34	134.0	COG3450@1|root,COG3450@2|Bacteria,2IHPC@201174|Actinobacteria,4FJSH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF861)	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
TLS3_k127_3107678_55	1193181.BN10_110004	5.371e-40	170.0	2DNRF@1|root,32YSD@2|Bacteria,2IAJC@201174|Actinobacteria,4FGZ6@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3107678_25	1386089.N865_01400	5.399e-116	385.0	COG2265@1|root,COG2265@2|Bacteria,2GP90@201174|Actinobacteria,4FFMI@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumB	-	2.1.1.189	ko:K03212	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
TLS3_k127_3107678_51	1193181.BN10_120030	5.823e-54	198.0	COG4852@1|root,COG4852@2|Bacteria,2GQ8R@201174|Actinobacteria,4FHD3@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2177
TLS3_k127_3107678_12	1385521.N803_11825	1.891e-175	566.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4FFI6@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 1 family	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS3_k127_3107678_2	1386089.N865_18330	9.215e-303	939.0	COG0366@1|root,COG0366@2|Bacteria,2GKT9@201174|Actinobacteria,4FEVJ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha amylase, catalytic domain	ams	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
TLS3_k127_3107678_29	1386089.N865_18325	3.519e-95	315.0	COG0009@1|root,COG0009@2|Bacteria,2GNEW@201174|Actinobacteria,4FF1Q@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
TLS3_k127_3107678_47	1385519.N801_19125	4.251e-58	211.0	COG1765@1|root,COG1765@2|Bacteria,2IRWN@201174|Actinobacteria,4FHCA@85021|Intrasporangiaceae	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
TLS3_k127_3107678_36	1385521.N803_07870	9.689e-86	293.0	COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria,4FGUS@85021|Intrasporangiaceae	201174|Actinobacteria	G	phosphoglycerate mutase	gpm2	GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
TLS3_k127_3107678_6	1193181.BN10_560003	4.85e-258	803.0	COG2170@1|root,COG2170@2|Bacteria,2GKCT@201174|Actinobacteria,4FEBB@85021|Intrasporangiaceae	201174|Actinobacteria	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
TLS3_k127_3107678_18	1385521.N803_07860	2.349e-145	469.0	COG0420@1|root,COG0420@2|Bacteria,2GK9R@201174|Actinobacteria,4FF0C@85021|Intrasporangiaceae	201174|Actinobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
TLS3_k127_3107678_10	367299.JOEE01000008_gene567	4.155e-208	683.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4FFJY@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG0419 ATPase involved in DNA repair	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
TLS3_k127_3107678_1	367299.JOEE01000008_gene566	0.0	1398.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4FF6T@85021|Intrasporangiaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
TLS3_k127_3107678_35	1172188.KB911823_gene588	1.623e-87	292.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4FERH@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS3_k127_3107678_50	1463845.JOIG01000002_gene2342	1.086e-55	209.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Uncharacterised ACR, COG1259	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
TLS3_k127_3107678_52	1385519.N801_02285	7.712e-53	195.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4FGAD@85021|Intrasporangiaceae	201174|Actinobacteria	K	MerR family	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
TLS3_k127_3107678_44	1193181.BN10_590006	3.125e-63	222.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4FH2P@85021|Intrasporangiaceae	201174|Actinobacteria	T	Signal peptide protein	garA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
TLS3_k127_3107678_53	188626.HMPREF0321_2899	4.6e-52	187.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,1ZW0I@145357|Dermacoccaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
TLS3_k127_3107678_38	1385520.N802_15075	2.874e-79	277.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,4FEXI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
TLS3_k127_3107678_54	1121017.AUFG01000005_gene984	9.414e-52	187.0	COG3856@1|root,COG3856@2|Bacteria,2IKJW@201174|Actinobacteria,4FGYG@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
TLS3_k127_3107678_45	367299.JOEE01000008_gene558	5.502e-62	224.0	COG3879@1|root,COG3879@2|Bacteria,2GMS5@201174|Actinobacteria,4FFPN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
TLS3_k127_3107678_39	367299.JOEE01000008_gene557	1.114e-71	254.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4FG5F@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS3_k127_3107678_28	710696.Intca_1499	4.508e-99	339.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,4FEW5@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_3107678_0	469371.Tbis_1618	0.0	1656.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4E0CI@85010|Pseudonocardiales	201174|Actinobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0047727,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	5.4.99.13,5.4.99.2	ko:K01848,ko:K11942	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
TLS3_k127_3107678_46	1306174.JODP01000013_gene7627	7.509e-61	216.0	COG1309@1|root,COG1846@1|root,COG1309@2|Bacteria,COG1846@2|Bacteria,2GKZA@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_3107678_57	1380370.JIBA01000014_gene2160	4.305e-39	152.0	COG4762@1|root,COG4762@2|Bacteria,2IQ4G@201174|Actinobacteria,4FGWV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1990)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1990
TLS3_k127_3107678_58	1240349.ANGC01000046_gene4688	1.229e-38	155.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,4G24E@85025|Nocardiaceae	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
TLS3_k127_3107678_30	196162.Noca_1499	1.182e-94	316.0	COG0702@1|root,COG0702@2|Bacteria,2GKXI@201174|Actinobacteria,4DQKC@85009|Propionibacteriales	201174|Actinobacteria	GM	PFAM NmrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS3_k127_3107678_63	58344.JOEL01000044_gene886	9.04e-08	54.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
TLS3_k127_3107678_5	710696.Intca_1833	7.428e-260	809.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4FED1@85021|Intrasporangiaceae	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
TLS3_k127_3107678_37	1385520.N802_15030	1.861e-79	282.0	COG0204@1|root,COG0204@2|Bacteria,2GP8A@201174|Actinobacteria,4FGGA@85021|Intrasporangiaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_3107678_34	367299.JOEE01000008_gene554	3.647e-89	310.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4FGBN@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyltransferase,Cytidylate_kin
TLS3_k127_3107678_19	1385518.N798_07820	4.528e-137	447.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4FF8J@85021|Intrasporangiaceae	201174|Actinobacteria	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
TLS3_k127_3107678_21	1193181.BN10_590041	2.86e-135	441.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4FEXM@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
TLS3_k127_3107678_33	367299.JOEE01000008_gene551	1.387e-90	303.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4FFUJ@85021|Intrasporangiaceae	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
TLS3_k127_3107678_24	1172188.KB911823_gene608	3.58e-127	414.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4FEWM@85021|Intrasporangiaceae	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
TLS3_k127_3107678_14	1122622.ATWJ01000010_gene1175	4.597e-164	520.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4FER8@85021|Intrasporangiaceae	201174|Actinobacteria	D	chromosome partitioning	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS3_k127_3107678_23	1210046.B277_08375	6.78e-128	431.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4FETP@85021|Intrasporangiaceae	201174|Actinobacteria	L	recombinase XerD	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
TLS3_k127_3107678_11	1193181.BN10_590046	3.719e-195	614.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4FEV5@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
TLS3_k127_3107678_48	1385519.N801_02160	1.318e-57	224.0	2DF72@1|root,32U4U@2|Bacteria,2GIV4@201174|Actinobacteria,4FH6P@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3107678_8	367299.JOEE01000008_gene545	1.03e-227	718.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4FFTM@85021|Intrasporangiaceae	201174|Actinobacteria	J	Histidine--tRNA ligase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
TLS3_k127_3107678_26	367299.JOEE01000008_gene544	7.342e-116	376.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4FEMC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_3107678_40	367299.JOEE01000008_gene543	1.899e-67	240.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4FG3D@85021|Intrasporangiaceae	201174|Actinobacteria	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
TLS3_k127_313232_24	1193181.BN10_550001	5.566e-99	325.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4FFG8@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS3_k127_313232_38	452652.KSE_12290	7.759e-54	196.0	COG0789@1|root,COG1225@1|root,COG0789@2|Bacteria,COG1225@2|Bacteria,2IIEZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1,Redoxin
TLS3_k127_313232_12	1385521.N803_08990	7.622e-170	555.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,4FEFB@85021|Intrasporangiaceae	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
TLS3_k127_313232_25	1463887.KL589977_gene8235	2.129e-89	312.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
TLS3_k127_313232_29	1157637.KB892156_gene3967	9.07e-83	280.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
TLS3_k127_313232_5	367299.JOEE01000005_gene3482	3.676e-226	717.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4FE66@85021|Intrasporangiaceae	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
TLS3_k127_313232_7	1385518.N798_08450	2.042e-218	684.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4FF9B@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
TLS3_k127_313232_11	1385518.N798_08465	1.05e-184	586.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4FEEJ@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
TLS3_k127_313232_43	1172188.KB911823_gene310	1.363e-35	138.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4FHAE@85021|Intrasporangiaceae	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
TLS3_k127_313232_26	367299.JOEE01000005_gene3476	9.235e-84	281.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4FG6C@85021|Intrasporangiaceae	201174|Actinobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
TLS3_k127_313232_44	1123322.KB904705_gene30	3.698e-35	138.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria	201174|Actinobacteria	J	integration host factor	mihF	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_313232_20	1193181.BN10_980008	2.089e-113	375.0	COG0284@1|root,COG0284@2|Bacteria,2GKWK@201174|Actinobacteria,4FFRF@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
TLS3_k127_313232_15	1380370.JIBA01000013_gene1640	3.467e-138	454.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4FFN6@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
TLS3_k127_313232_16	1193181.BN10_980010	4.424e-136	447.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4FFS3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dihydroorotate oxidase	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TLS3_k127_313232_0	367299.JOEE01000005_gene3471	0.0	1830.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4FEJ7@85021|Intrasporangiaceae	201174|Actinobacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
TLS3_k127_313232_10	1385518.N798_08505	1.012e-194	616.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4FFSI@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
TLS3_k127_313232_9	1385518.N798_08510	4.756e-204	643.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4FE6N@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
TLS3_k127_313232_14	710696.Intca_1601	1.201e-150	490.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4FEMK@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS3_k127_313232_31	367299.JOEE01000005_gene3467	3.851e-80	271.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4FFMC@85021|Intrasporangiaceae	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
TLS3_k127_313232_28	1184609.KILIM_015_00410	4.163e-83	301.0	COG0454@1|root,COG0494@1|root,COG0456@2|Bacteria,COG0494@2|Bacteria,2II3I@201174|Actinobacteria	201174|Actinobacteria	K	Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
TLS3_k127_313232_34	1385518.N798_08550	1.712e-57	207.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4FH3C@85021|Intrasporangiaceae	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
TLS3_k127_313232_22	1193181.BN10_980019	1.994e-103	340.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4FEXN@85021|Intrasporangiaceae	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
TLS3_k127_313232_4	1193181.BN10_120032	1.583e-243	768.0	COG1502@1|root,COG1502@2|Bacteria,2GN2V@201174|Actinobacteria,4FE9K@85021|Intrasporangiaceae	201174|Actinobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc,PLDc_2
TLS3_k127_313232_17	1121017.AUFG01000004_gene3175	1.669e-125	417.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4FEDZ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
TLS3_k127_313232_37	1123251.ATWM01000002_gene458	6.179e-54	199.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4FGP3@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
TLS3_k127_313232_8	710696.Intca_1592	1.672e-206	647.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4FEAA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
TLS3_k127_313232_42	1385521.N803_09335	1.005e-35	151.0	COG1989@1|root,COG1989@2|Bacteria,2HH3Y@201174|Actinobacteria,4FH5M@85021|Intrasporangiaceae	201174|Actinobacteria	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	Peptidase_A24
TLS3_k127_313232_30	1193181.BN10_500025	3.017e-81	280.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4FEUA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Shikimate	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
TLS3_k127_313232_23	367299.JOEE01000005_gene3454	6.332e-103	356.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4FFI0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
TLS3_k127_313232_40	1386089.N865_01030	7.305e-44	170.0	COG0816@1|root,COG0816@2|Bacteria,2IQB0@201174|Actinobacteria,4FGUB@85021|Intrasporangiaceae	201174|Actinobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
TLS3_k127_313232_1	1121017.AUFG01000004_gene3169	0.0	1270.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4FE6Z@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
TLS3_k127_313232_6	1385518.N798_08665	6.452e-221	692.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4FF0D@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
TLS3_k127_313232_39	1238186.AOCN01000022_gene2284	5.207e-49	184.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,4FQ1M@85023|Microbacteriaceae	201174|Actinobacteria	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
TLS3_k127_313232_35	367299.JOEE01000005_gene3446	2.498e-56	207.0	COG3393@1|root,COG3393@2|Bacteria,2IKNJ@201174|Actinobacteria,4FGI3@85021|Intrasporangiaceae	201174|Actinobacteria	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47
TLS3_k127_313232_18	1410634.JHVD01000023_gene2049	1.02e-121	406.0	COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria,4DT3N@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
TLS3_k127_313232_2	367299.JOEE01000005_gene3444	0.0	1047.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4FEN0@85021|Intrasporangiaceae	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
TLS3_k127_313232_21	1223542.GM1_006_00190	1.207e-105	363.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4GA3Q@85026|Gordoniaceae	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_313232_33	367299.JOEE01000005_gene3441	3.76e-60	215.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4FH1U@85021|Intrasporangiaceae	201174|Actinobacteria	L	ADP-ribose pyrophosphatase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS3_k127_313232_3	367299.JOEE01000005_gene3440	2.393e-307	960.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4FF55@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
TLS3_k127_313232_27	313589.JNB_04250	4.004e-83	299.0	COG0297@1|root,COG0297@2|Bacteria,2I4SY@201174|Actinobacteria,4FJYR@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_313232_19	1385520.N802_16700	1.431e-119	408.0	COG0728@1|root,COG0728@2|Bacteria,2GKWW@201174|Actinobacteria,4FEG2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Virulence factor MVIN	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS3_k127_313232_32	367299.JOEE01000005_gene3437	1.133e-76	269.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria,4FGJE@85021|Intrasporangiaceae	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_313232_41	1385518.N798_08745	7.853e-38	158.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4FHB0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
TLS3_k127_313232_13	266940.Krad_3146	1.724e-161	518.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria	201174|Actinobacteria	S	Thiamin pyrophosphokinase	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
TLS3_k127_313232_36	367299.JOEE01000005_gene3434	2.217e-55	199.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4FEM6@85021|Intrasporangiaceae	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
TLS3_k127_3303260_2	1385518.N798_14335	2.405e-91	304.0	COG1122@1|root,COG1122@2|Bacteria,2GMK1@201174|Actinobacteria,4FF62@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter (Permease)	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF_trnsprt
TLS3_k127_3303260_3	1385520.N802_01300	5.294e-89	296.0	COG1051@1|root,COG1051@2|Bacteria,2GJGZ@201174|Actinobacteria,4FEBX@85021|Intrasporangiaceae	201174|Actinobacteria	F	ADP-ribose pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4916
TLS3_k127_3303260_1	1385520.N802_01305	1.033e-107	357.0	COG0204@1|root,COG0204@2|Bacteria,2GKM6@201174|Actinobacteria,4FEZZ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_3303260_0	367299.JOEE01000003_gene2758	1.114e-259	805.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4FF4K@85021|Intrasporangiaceae	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS3_k127_334220_5	1385521.N803_02345	1.714e-28	123.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4FHA9@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds the 23S rRNA	rpmE	GO:0008150,GO:0040007	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
TLS3_k127_334220_4	1122622.ATWJ01000007_gene1642	1.482e-87	304.0	COG0697@1|root,COG0697@2|Bacteria,2GMPB@201174|Actinobacteria,4FFGP@85021|Intrasporangiaceae	201174|Actinobacteria	EG	ABC transporter (Permease)	-	-	-	ko:K15269	-	-	-	-	ko00000,ko02000	2.A.7.3.3	-	-	EamA
TLS3_k127_334220_0	1385520.N802_02445	1.787e-230	732.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4FEFD@85021|Intrasporangiaceae	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
TLS3_k127_334220_3	367299.JOEE01000004_gene985	8.026e-110	364.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4FE3Y@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
TLS3_k127_334220_1	1172188.KB911821_gene1605	2.742e-191	608.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4FEKS@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_334220_2	1386089.N865_21920	4.416e-179	566.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4FEDW@85021|Intrasporangiaceae	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
TLS3_k127_343085_1	710696.Intca_0074	8.208e-183	581.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	gtsA	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_343085_0	1193181.BN10_540007	0.0	1692.0	28HY3@1|root,2Z83I@2|Bacteria,2H218@201174|Actinobacteria	201174|Actinobacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_343085_3	1385521.N803_14200	6.814e-151	482.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4FHJS@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_343085_4	408672.NBCG_04123	1.583e-43	161.0	COG1158@1|root,COG1158@2|Bacteria,2IKUK@201174|Actinobacteria,4DR4P@85009|Propionibacteriales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_343085_2	1386089.N865_18630	2.676e-153	490.0	COG3569@1|root,COG3569@2|Bacteria,2GJTH@201174|Actinobacteria,4FERI@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA topoisomerase	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
TLS3_k127_34371_4	1210046.B277_06493	1.299e-51	186.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4FEZ8@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
TLS3_k127_34371_0	935866.JAER01000009_gene719	4.595e-214	678.0	COG1292@1|root,COG1292@2|Bacteria,2GJX0@201174|Actinobacteria,4DNXJ@85009|Propionibacteriales	201174|Actinobacteria	M	BCCT, betaine/carnitine/choline family transporter	-	-	-	ko:K02168	-	-	-	-	ko00000,ko02000	2.A.15.1.3,2.A.15.1.4	-	-	BCCT
TLS3_k127_34371_2	1385518.N798_03040	1.75e-162	520.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4FERB@85021|Intrasporangiaceae	201174|Actinobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
TLS3_k127_34371_3	1273125.Rrhod_2164	2.45e-52	194.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4FWDP@85025|Nocardiaceae	201174|Actinobacteria	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
TLS3_k127_34371_1	1193181.BN10_680076	1.914e-176	558.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4FERT@85021|Intrasporangiaceae	201174|Actinobacteria	T	Phosphate starvation protein PhoH	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
TLS3_k127_34371_6	570268.ANBB01000046_gene1390	4.668e-39	149.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4EJSG@85012|Streptosporangiales	201174|Actinobacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
TLS3_k127_34371_5	28444.JODQ01000001_gene2583	1.039e-44	172.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria,4EGWT@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_3441642_11	1193181.BN10_780004	8.231e-17	87.0	COG2501@1|root,COG2501@2|Bacteria,2GQG8@201174|Actinobacteria,4FI0J@85021|Intrasporangiaceae	201174|Actinobacteria	S	S4 domain	yaaA	-	-	ko:K14761	-	-	-	-	ko00000,ko03009	-	-	-	S4_2
TLS3_k127_3441642_3	1385518.N798_01750	2.552e-235	752.0	COG1408@1|root,COG3371@1|root,COG1408@2|Bacteria,COG3371@2|Bacteria,2HIFX@201174|Actinobacteria,4FF80@85021|Intrasporangiaceae	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	DUF998,Metallophos
TLS3_k127_3441642_7	2074.JNYD01000005_gene3238	1.046e-175	585.0	COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria	201174|Actinobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2,Phosphodiest
TLS3_k127_3441642_6	1184609.KILIM_013_00060	1.925e-198	631.0	COG4262@1|root,COG4262@2|Bacteria,2I372@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
TLS3_k127_3441642_1	2045.KR76_17545	4.045e-271	847.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DNTY@85009|Propionibacteriales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_3441642_9	1122622.ATWJ01000007_gene1561	8.638e-36	138.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,4FH9Q@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS3_k127_3441642_0	367299.JOEE01000007_gene110	3.004e-279	872.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GITZ@201174|Actinobacteria,4FEHT@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS3_k127_3441642_4	710696.Intca_1022	5.085e-206	644.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4FEQQ@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the synthesis of xanthosine monophosphate by the NAD dependent oxidation of inosine monophosphate	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
TLS3_k127_3441642_10	1127134.NOCYR_4633	1.089e-29	126.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria,4G0K6@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS3_k127_3441642_5	367299.JOEE01000007_gene103	4.283e-199	633.0	COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FFEM@85021|Intrasporangiaceae	201174|Actinobacteria	C	part of alternative pathway from alpha-ketoglutarate to succinate	gabD2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_3441642_2	313589.JNB_17568	9.18e-267	859.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4FEPD@85021|Intrasporangiaceae	201174|Actinobacteria	E	Cholesterol oxidase	choD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N
TLS3_k127_3441642_8	1385519.N801_10055	9.749e-162	534.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4FFJA@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_3443139_11	710696.Intca_2049	6.071e-20	96.0	COG0328@1|root,COG0328@2|Bacteria,2I4IN@201174|Actinobacteria,4FF0E@85021|Intrasporangiaceae	201174|Actinobacteria	L	Reverse transcriptase-like	-	-	3.1.26.4,3.1.3.73	ko:K03469,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Glyoxalase_4,His_Phos_1,RVT_3
TLS3_k127_3443139_7	1193181.BN10_730017	3.866e-85	289.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4FFIN@85021|Intrasporangiaceae	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
TLS3_k127_3443139_1	1304865.JAGF01000001_gene120	8.498e-136	451.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4F0HN@85016|Cellulomonadaceae	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS3_k127_3443139_4	1304865.JAGF01000001_gene121	2.4e-106	357.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
TLS3_k127_3443139_3	1304865.JAGF01000001_gene122	2.965e-111	380.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
TLS3_k127_3443139_2	367299.JOEE01000010_gene3337	1.491e-113	374.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4FFKW@85021|Intrasporangiaceae	201174|Actinobacteria	S	NIF3 (NGG1p interacting factor 3)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
TLS3_k127_3443139_8	1121017.AUFG01000050_gene3529	5.586e-60	215.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4FGWJ@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peroxiredoxin	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
TLS3_k127_3443139_9	1172188.KB911827_gene4171	3.489e-40	168.0	2B57P@1|root,32TPU@2|Bacteria,2I89I@201174|Actinobacteria,4FK3Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3052)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
TLS3_k127_3443139_5	1385521.N803_00260	3.367e-98	340.0	COG3428@1|root,COG3428@2|Bacteria,2GJCD@201174|Actinobacteria,4FFQR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
TLS3_k127_3443139_12	1033730.CAHG01000013_gene1325	9.958e-18	94.0	COG3402@1|root,COG3402@2|Bacteria,2IR88@201174|Actinobacteria,4DRVV@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
TLS3_k127_3443139_6	367299.JOEE01000010_gene3343	1.757e-85	297.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4FGGC@85021|Intrasporangiaceae	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
TLS3_k127_3443139_10	1385520.N802_10870	8.777e-30	123.0	2DGAU@1|root,2ZV6Z@2|Bacteria,2I6MX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3443139_0	367299.JOEE01000010_gene3344	0.0	1079.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4FEUZ@85021|Intrasporangiaceae	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
TLS3_k127_3505349_31	1385520.N802_15790	5.485e-10	61.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4FFMT@85021|Intrasporangiaceae	201174|Actinobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
TLS3_k127_3505349_23	710696.Intca_1009	5.255e-53	199.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4FGQ5@85021|Intrasporangiaceae	201174|Actinobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
TLS3_k127_3505349_19	313589.JNB_17433	9.97e-70	244.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,4FH78@85021|Intrasporangiaceae	201174|Actinobacteria	O	peptidase M22	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
TLS3_k127_3505349_24	1385519.N801_00010	7.045e-52	201.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4FGWH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
TLS3_k127_3505349_17	1385520.N802_15770	7.086e-88	304.0	COG2267@1|root,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria,4FE54@85021|Intrasporangiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
TLS3_k127_3505349_27	367299.JOEE01000007_gene137	3.62e-44	162.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4FESS@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS3_k127_3505349_14	367299.JOEE01000007_gene137	5.207e-100	337.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4FESS@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
TLS3_k127_3505349_8	1043205.AFYF01000034_gene189	6.277e-136	436.0	COG1028@1|root,COG1028@2|Bacteria,2GKE1@201174|Actinobacteria,4FFWP@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_3505349_4	1120947.ATUX01000007_gene905	7.675e-177	568.0	COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4D4UK@85005|Actinomycetales	201174|Actinobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
TLS3_k127_3505349_20	402777.KB235898_gene5687	2.809e-63	233.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1FZXP@1117|Cyanobacteria,1H9FJ@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
TLS3_k127_3505349_2	1385518.N798_11625	1.022e-317	986.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4FF11@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
TLS3_k127_3505349_21	367299.JOEE01000007_gene163	3.99e-54	195.0	2DM0Y@1|root,318KY@2|Bacteria,2IMIX@201174|Actinobacteria,4FGTH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
TLS3_k127_3505349_12	258533.BN977_00861	2.66e-106	354.0	COG1752@1|root,COG1752@2|Bacteria,2IA6V@201174|Actinobacteria,234Z5@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS3_k127_3505349_0	1385518.N798_16410	0.0	1096.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FE8Z@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_12
TLS3_k127_3505349_16	1172185.KB911515_gene2282	7.949e-97	324.0	COG2755@1|root,COG2755@2|Bacteria,2GRDF@201174|Actinobacteria	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS3_k127_3505349_28	477641.MODMU_2447	8.558e-42	173.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS3_k127_3505349_5	367299.JOEE01000007_gene138	2.015e-175	562.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4FFIU@85021|Intrasporangiaceae	201174|Actinobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
TLS3_k127_3505349_29	935839.JAGJ01000006_gene3350	7.34e-40	151.0	COG0736@1|root,COG0736@2|Bacteria,2IQF6@201174|Actinobacteria,4F4PM@85017|Promicromonosporaceae	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS3_k127_3505349_1	313589.JNB_17403	0.0	1050.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4FEZD@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
TLS3_k127_3505349_7	1385518.N798_09630	1.099e-149	480.0	COG1072@1|root,COG1072@2|Bacteria,2GIRR@201174|Actinobacteria,4FEP5@85021|Intrasporangiaceae	201174|Actinobacteria	H	Pantothenic acid kinase	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
TLS3_k127_3505349_22	367299.JOEE01000007_gene142	5.314e-54	199.0	COG3583@1|root,COG3583@2|Bacteria,2I2GH@201174|Actinobacteria,4FH0B@85021|Intrasporangiaceae	201174|Actinobacteria	S	G5 domain protein	-	-	-	ko:K21688	-	-	-	-	ko00000	-	-	-	DUF348,G5,SLT
TLS3_k127_3505349_3	1386089.N865_19735	1.44e-248	772.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4FEBP@85021|Intrasporangiaceae	201174|Actinobacteria	T	ATP-binding protein	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
TLS3_k127_3505349_10	1385519.N801_00995	1.358e-125	405.0	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4FFWU@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS1	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS3_k127_3505349_15	1121385.AQXW01000001_gene776	7.287e-97	322.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,1ZW8F@145357|Dermacoccaceae	201174|Actinobacteria	S	hemolysin III	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
TLS3_k127_3505349_32	1385521.N803_13500	5.024e-07	59.0	28XBN@1|root,2ZJ9I@2|Bacteria,2H155@201174|Actinobacteria,4FI2N@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3505349_6	1385520.N802_15715	1.442e-153	499.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4FF2U@85021|Intrasporangiaceae	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	mca	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
TLS3_k127_3505349_30	1386089.N865_19765	2.077e-15	89.0	2DRBP@1|root,33B4I@2|Bacteria,2HXMR@201174|Actinobacteria,4FHEF@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4307
TLS3_k127_3505349_18	1386089.N865_19770	2.452e-72	247.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4FGFC@85021|Intrasporangiaceae	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
TLS3_k127_3505349_26	1121017.AUFG01000014_gene2004	1.051e-47	181.0	COG3593@1|root,COG3593@2|Bacteria,2GMN5@201174|Actinobacteria,4FH9W@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA synthesis involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3505349_11	196162.Noca_4606	3.081e-109	361.0	COG0454@1|root,COG0456@2|Bacteria,2I9GA@201174|Actinobacteria,4DPHN@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_3505349_13	397278.JOJN01000003_gene1974	3.053e-106	358.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4DQ35@85009|Propionibacteriales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS3_k127_3505349_9	593907.Celgi_1929	1.847e-134	436.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS3_k127_3505349_25	1193181.BN10_920048	1.313e-48	179.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4FG1Q@85021|Intrasporangiaceae	201174|Actinobacteria	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS3_k127_3519895_19	1210046.B277_09019	2.579e-29	120.0	COG2733@1|root,COG2733@2|Bacteria,2GKGM@201174|Actinobacteria,4FFFE@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
TLS3_k127_3519895_6	1172188.KB911820_gene3134	2.538e-232	726.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GNDC@201174|Actinobacteria,4FEWT@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the synthesis of xanthosine monophosphate by the NAD dependent oxidation of inosine monophosphate	guaB1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
TLS3_k127_3519895_11	1193181.BN10_1690002	1.641e-161	521.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4FE7U@85021|Intrasporangiaceae	201174|Actinobacteria	E	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
TLS3_k127_3519895_16	1043205.AFYF01000064_gene2201	1.019e-45	168.0	COG0789@1|root,COG0789@2|Bacteria,2IQGQ@201174|Actinobacteria,4FHR8@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS3_k127_3519895_1	1043205.AFYF01000064_gene2200	5.148e-276	861.0	COG4108@1|root,COG4108@2|Bacteria,2GKQA@201174|Actinobacteria,4FG7N@85021|Intrasporangiaceae	201174|Actinobacteria	J	Class II release factor RF3, C-terminal domain	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
TLS3_k127_3519895_2	1122622.ATWJ01000012_gene935	9.041e-267	830.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4FFQ2@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS3_k127_3519895_12	1146883.BLASA_1107	5.009e-106	348.0	COG0421@1|root,COG0421@2|Bacteria,2I2TN@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3519895_10	1429046.RR21198_3338	1.553e-164	541.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4FUIH@85025|Nocardiaceae	201174|Actinobacteria	EI	Phosphate acyltransferases	plsC	-	2.3.1.51,3.1.3.3	ko:K00655,ko:K15781	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,HAD
TLS3_k127_3519895_4	1240349.ANGC01000016_gene758	2.796e-240	767.0	COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,4FWRE@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_3519895_22	1380370.JIBA01000013_gene1595	9.179e-07	55.0	290XR@1|root,2ZNJH@2|Bacteria,2GPXK@201174|Actinobacteria,4FHG9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3519895_8	1385520.N802_12985	3.268e-166	535.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4FFUD@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	vdh	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.4.1.23	ko:K00271	ko00280,ko01100,ko01110,ko01130,map00280,map01100,map01110,map01130	-	R01212,R01434	RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
TLS3_k127_3519895_20	1193181.BN10_650017	1.575e-19	89.0	2EGRW@1|root,33AI2@2|Bacteria,2IQF3@201174|Actinobacteria,4FI3J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3073)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3073
TLS3_k127_3519895_7	1385521.N803_04980	1.631e-183	583.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4FF3D@85021|Intrasporangiaceae	201174|Actinobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
TLS3_k127_3519895_14	1385519.N801_06760	1.703e-65	252.0	COG1335@1|root,COG1335@2|Bacteria,2IN6N@201174|Actinobacteria,4FGXA@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
TLS3_k127_3519895_3	313589.JNB_15848	2.267e-254	793.0	COG1457@1|root,COG1457@2|Bacteria,2GJ6B@201174|Actinobacteria,4FF2C@85021|Intrasporangiaceae	201174|Actinobacteria	U	Belongs to the purine-cytosine permease (2.A.39) family	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
TLS3_k127_3519895_0	1385518.N798_01000	1.196e-280	868.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4FEQP@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
TLS3_k127_3519895_23	378753.KRH_04250	1.36e-05	50.0	2ER8U@1|root,33IUE@2|Bacteria,2GXJ3@201174|Actinobacteria,1WA8W@1268|Micrococcaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3519895_9	1385521.N803_04970	6.21e-165	577.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4FE2W@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
TLS3_k127_3519895_13	1193181.BN10_1030005	1.47e-71	256.0	COG2335@1|root,COG2335@2|Bacteria,2GJC2@201174|Actinobacteria,4FGIX@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fasciclin	mpt	GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043207,GO:0044403,GO:0044419,GO:0044421,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	-	-	-	-	-	-	-	-	-	Fasciclin
TLS3_k127_3519895_15	196162.Noca_4535	2.547e-65	230.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4DR5C@85009|Propionibacteriales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_3519895_18	2045.KR76_01090	3.553e-31	138.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria,4DQNV@85009|Propionibacteriales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	rskA	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
TLS3_k127_3519895_17	1386089.N865_05820	3.566e-42	158.0	COG3255@1|root,COG3255@2|Bacteria,2IQBF@201174|Actinobacteria,4FH9C@85021|Intrasporangiaceae	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
TLS3_k127_3519895_5	1210046.B277_07980	4.852e-235	747.0	COG0737@1|root,COG0737@2|Bacteria,2GKC3@201174|Actinobacteria,4FEPR@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Big_3_5,Exo_endo_phos,LTD,Metallophos
TLS3_k127_3566604_28	1385519.N801_11480	2.87e-116	378.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4FEY1@85021|Intrasporangiaceae	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS3_k127_3566604_5	1385521.N803_08565	0.0	1091.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4FF5M@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS3_k127_3566604_12	1193181.BN10_1080007	9.388e-173	548.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4FEYQ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS3_k127_3566604_8	367299.JOEE01000005_gene3585	2.961e-211	670.0	COG0166@1|root,COG0166@2|Bacteria,2HX58@201174|Actinobacteria,4FEPU@85021|Intrasporangiaceae	201174|Actinobacteria	G	Glucose-6-phosphate isomerase	-	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
TLS3_k127_3566604_40	1122622.ATWJ01000008_gene2897	8.043e-24	106.0	2EP1F@1|root,33GNA@2|Bacteria,2IP6Q@201174|Actinobacteria,4FH5W@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF3806)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3806
TLS3_k127_3566604_35	1193181.BN10_1080003	1.873e-57	208.0	2CNY9@1|root,31GEE@2|Bacteria,2IKKZ@201174|Actinobacteria,4FH2D@85021|Intrasporangiaceae	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	-	-	-	-	-	-	-	-	-	-	-	RbpA
TLS3_k127_3566604_39	1385520.N802_17355	4.607e-31	129.0	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria,4FHB6@85021|Intrasporangiaceae	201174|Actinobacteria	U	Preprotein translocase subunit SecG	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
TLS3_k127_3566604_18	1193181.BN10_1080001	3.281e-141	451.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,4FFF9@85021|Intrasporangiaceae	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
TLS3_k127_3566604_9	1193181.BN10_810037	1.108e-206	650.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4FEMD@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
TLS3_k127_3566604_10	367299.JOEE01000005_gene3576	4.125e-196	613.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4FEJU@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
TLS3_k127_3566604_11	1385520.N802_17335	1.155e-175	555.0	COG1481@1|root,COG1481@2|Bacteria,2GJZU@201174|Actinobacteria,4FEE7@85021|Intrasporangiaceae	201174|Actinobacteria	K	May be required for sporulation	whiA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
TLS3_k127_3566604_21	1385520.N802_17330	1.977e-133	439.0	COG0391@1|root,COG0391@2|Bacteria,2GJBW@201174|Actinobacteria,4FEGA@85021|Intrasporangiaceae	201174|Actinobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
TLS3_k127_3566604_29	710696.Intca_1681	1.343e-115	381.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4FERR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
TLS3_k127_3566604_6	1210046.B277_09947	1.528e-301	936.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4FF9H@85021|Intrasporangiaceae	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
TLS3_k127_3566604_38	1169154.KB897784_gene4271	8.275e-35	138.0	COG0723@1|root,COG0723@2|Bacteria,2I2JE@201174|Actinobacteria	201174|Actinobacteria	C	PFAM Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
TLS3_k127_3566604_13	1122609.AUGT01000012_gene4371	1.102e-165	533.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,4DPSP@85009|Propionibacteriales	201174|Actinobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
TLS3_k127_3566604_23	1122609.AUGT01000012_gene4368	2.024e-129	418.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DPW5@85009|Propionibacteriales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS3_k127_3566604_17	1122609.AUGT01000012_gene4367	2.152e-141	456.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DN7C@85009|Propionibacteriales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_3566604_19	979556.MTES_0807	2.227e-134	439.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4FMMG@85023|Microbacteriaceae	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_3566604_22	1122609.AUGT01000012_gene4365	1.683e-131	432.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4DNAX@85009|Propionibacteriales	201174|Actinobacteria	P	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2,CarboxypepD_reg
TLS3_k127_3566604_0	1385518.N798_14690	0.0	1715.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4FEFC@85021|Intrasporangiaceae	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
TLS3_k127_3566604_31	1385520.N802_17270	1.569e-102	339.0	COG0491@1|root,COG0491@2|Bacteria,2GKJA@201174|Actinobacteria,4FEVB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Zn-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_3566604_27	1385519.N801_11345	4.647e-122	398.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria,4FFA4@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	rhtA_1	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
TLS3_k127_3566604_34	1193181.BN10_770001	6.099e-65	226.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4FEUG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Tellurium resistance protein TerC	terC	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS3_k127_3566604_33	367299.JOEE01000005_gene3558	5.774e-68	239.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4FEUG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Tellurium resistance protein TerC	terC	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS3_k127_3566604_3	367299.JOEE01000005_gene3557	0.0	1251.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4FF3M@85021|Intrasporangiaceae	201174|Actinobacteria	C	Phosphoenolpyruvate carboxylase	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS3_k127_3566604_4	1193181.BN10_1380002	0.0	1244.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4FF7R@85021|Intrasporangiaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
TLS3_k127_3566604_16	1385520.N802_17230	4.513e-142	462.0	COG0237@1|root,COG2320@1|root,COG0237@2|Bacteria,COG2320@2|Bacteria,2GN96@201174|Actinobacteria,4FE98@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
TLS3_k127_3566604_7	1385521.N803_08750	3.392e-274	853.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4FF0W@85021|Intrasporangiaceae	201174|Actinobacteria	J	in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
TLS3_k127_3566604_32	1385519.N801_11260	7.912e-98	326.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4FE9X@85021|Intrasporangiaceae	201174|Actinobacteria	Q	SAM-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_3566604_30	1385519.N801_11255	3.261e-110	366.0	2B1K4@1|root,31U1J@2|Bacteria,2I8GP@201174|Actinobacteria,4FEAW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3068)	porA	-	-	-	-	-	-	-	-	-	-	-	DUF3068
TLS3_k127_3566604_36	1136417.AZWE01000049_gene4743	1.437e-49	194.0	COG1835@1|root,COG1835@2|Bacteria,2GP6W@201174|Actinobacteria,4DM2A@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_3566604_2	1385518.N798_14550	0.0	1309.0	COG1287@1|root,COG1287@2|Bacteria,2I2SP@201174|Actinobacteria,4FFW6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF3367)	-	-	-	ko:K16648	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	DUF3367,F5_F8_type_C
TLS3_k127_3566604_25	1385518.N798_14545	4.199e-125	406.0	COG2227@1|root,COG2227@2|Bacteria,2I48Y@201174|Actinobacteria,4FJYQ@85021|Intrasporangiaceae	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_3566604_14	1385518.N798_14540	5.425e-163	520.0	COG0438@1|root,COG0438@2|Bacteria,2GK8D@201174|Actinobacteria,4FEXG@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_3566604_15	1385518.N798_14530	2.545e-148	490.0	28HIC@1|root,2Z7TU@2|Bacteria,2GNK5@201174|Actinobacteria,4FF9U@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3566604_20	1385518.N798_14525	1.628e-133	436.0	COG1835@1|root,COG1835@2|Bacteria,2GP6W@201174|Actinobacteria,4FIZ0@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_3566604_24	1385518.N798_14520	2.139e-125	407.0	COG2227@1|root,COG2227@2|Bacteria,2GMMX@201174|Actinobacteria,4FIJN@85021|Intrasporangiaceae	201174|Actinobacteria	H	Methionine biosynthesis protein MetW	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
TLS3_k127_3566604_37	313589.JNB_03745	1.685e-36	146.0	2B8KB@1|root,321VN@2|Bacteria,2H61N@201174|Actinobacteria,4FJ7A@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3566604_41	313589.JNB_03750	4.402e-14	78.0	29N3W@1|root,3091M@2|Bacteria,2HAPP@201174|Actinobacteria,4FJMI@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3566604_1	1385520.N802_17150	0.0	1361.0	COG1572@1|root,COG1572@2|Bacteria,2I56C@201174|Actinobacteria,4FK2X@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF3367)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3367
TLS3_k127_3566604_26	1385518.N798_14500	5.691e-124	400.0	COG0500@1|root,COG2226@2|Bacteria,2IMHF@201174|Actinobacteria,4FIRA@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_3566604_42	1121385.AQXW01000004_gene905	1.975e-12	67.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,1ZVCS@145357|Dermacoccaceae	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS3_k127_3595034_2	1385520.N802_02205	8.415e-102	333.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4FFKA@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADPH quinone reductase	ccr	-	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_3595034_4	1193181.BN10_1170015	6.707e-75	255.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4FGBB@85021|Intrasporangiaceae	201174|Actinobacteria	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
TLS3_k127_3595034_0	367299.JOEE01000004_gene1020	2.332e-223	697.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FE3A@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadA4	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_3595034_1	1184609.KILIM_025_00190	1.777e-157	502.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4F66B@85018|Dermatophilaceae	201174|Actinobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
TLS3_k127_3595034_7	367299.JOEE01000004_gene1025	1.377e-29	126.0	2AS48@1|root,31HH0@2|Bacteria,2IKT1@201174|Actinobacteria,4FH0Y@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3595034_6	1385519.N801_13625	7.627e-52	199.0	2C0QS@1|root,32R7D@2|Bacteria,2HXB6@201174|Actinobacteria,4FH6N@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3595034_3	1172188.KB911821_gene1551	3.257e-78	272.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4FFJ3@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin	ybbN	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
TLS3_k127_3595034_5	367299.JOEE01000004_gene1028	9.372e-55	205.0	COG2382@1|root,COG2382@2|Bacteria,2HZ1I@201174|Actinobacteria,4FEYB@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS3_k127_3609829_8	1385518.N798_06985	1.481e-96	322.0	COG3239@1|root,COG3239@2|Bacteria,2H2JW@201174|Actinobacteria,4FFD7@85021|Intrasporangiaceae	201174|Actinobacteria	I	fatty acid desaturase	desA3	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
TLS3_k127_3609829_6	313589.JNB_13863	4.585e-156	500.0	COG1018@1|root,COG1018@2|Bacteria,2GJSW@201174|Actinobacteria,4FEMH@85021|Intrasporangiaceae	201174|Actinobacteria	C	Stearoyl-CoA 9-desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
TLS3_k127_3609829_10	1121381.JNIV01000001_gene2856	6.909e-55	203.0	COG1834@1|root,COG1834@2|Bacteria	2|Bacteria	E	dimethylargininase activity	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
TLS3_k127_3609829_4	512565.AMIS_39760	3.261e-180	573.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4DHJ8@85008|Micromonosporales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_3609829_12	1184609.KILIM_029_00080	1.126e-52	207.0	COG0431@1|root,COG0431@2|Bacteria,2IHWU@201174|Actinobacteria	201174|Actinobacteria	S	fmn reductase	ssuE	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
TLS3_k127_3609829_3	1184609.KILIM_029_00090	1.764e-202	636.0	COG2141@1|root,COG2141@2|Bacteria,2GKCU@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_3609829_16	1214101.BN159_0849	2.993e-15	81.0	COG0457@1|root,COG0457@2|Bacteria,2IKRV@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
TLS3_k127_3609829_5	390989.JOEG01000001_gene5036	3.716e-180	573.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4DB8Z@85008|Micromonosporales	201174|Actinobacteria	S	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
TLS3_k127_3609829_7	1210046.B277_15644	1.636e-147	486.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4FE71@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	Membrane	mviN	GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
TLS3_k127_3609829_15	1122611.KB903972_gene2426	1.817e-21	107.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4EGXF@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS3_k127_3609829_13	710696.Intca_2408	4.317e-47	172.0	COG0011@1|root,COG0011@2|Bacteria,2IQ7E@201174|Actinobacteria,4FHGI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Thiamine-binding protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
TLS3_k127_3609829_14	1089544.KB912942_gene1622	8.194e-44	169.0	COG2761@1|root,COG2761@2|Bacteria,2GTIT@201174|Actinobacteria	201174|Actinobacteria	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3609829_9	710696.Intca_0071	8.519e-73	252.0	2DBXI@1|root,2ZBQ3@2|Bacteria,2GJN1@201174|Actinobacteria,4FGVD@85021|Intrasporangiaceae	201174|Actinobacteria	S	Peptidase M50B-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
TLS3_k127_3609829_0	1193181.BN10_1380009	1.96e-286	889.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4FG5T@85021|Intrasporangiaceae	201174|Actinobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38,4.1.1.101	ko:K00027,ko:K22212	ko00620,ko01120,ko01200,ko02020,map00620,map01120,map01200,map02020	-	R00214,R11074	RC00105,RC00282	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
TLS3_k127_3609829_1	1120960.ATXG01000022_gene1299	2.311e-274	857.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS3_k127_3609829_2	1120959.ATXF01000005_gene985	8.012e-231	731.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS3_k127_3609829_11	1120960.ATXG01000022_gene1300	3.458e-54	198.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS3_k127_3611536_0	1385520.N802_17565	0.0	1346.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,2GN0U@201174|Actinobacteria,4FESF@85021|Intrasporangiaceae	201174|Actinobacteria	HJM	Belongs to the MurCDEF family	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,Mur_ligase_C,Mur_ligase_M,RimK
TLS3_k127_3611536_4	1385518.N798_14975	9.319e-245	777.0	COG0769@1|root,COG0769@2|Bacteria,2GME3@201174|Actinobacteria,4FF9P@85021|Intrasporangiaceae	201174|Actinobacteria	M	Tetratrico peptide repeat	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,TPR_5
TLS3_k127_3611536_10	1121385.AQXW01000004_gene1125	2.02e-130	430.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,1ZVMK@145357|Dermacoccaceae	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208,ko:K11611	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_3611536_11	1172188.KB911823_gene475	9.869e-99	336.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4FF2A@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_3611536_17	1385521.N803_08385	1.239e-18	89.0	2EGIC@1|root,33AAH@2|Bacteria,2HXU5@201174|Actinobacteria,4FHR6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3099)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3099
TLS3_k127_3611536_7	1385519.N801_11615	9.507e-169	543.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4FFGU@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
TLS3_k127_3611536_12	1385518.N798_14945	1.077e-79	277.0	COG3346@1|root,COG3346@2|Bacteria,2GR90@201174|Actinobacteria,4FGD6@85021|Intrasporangiaceae	201174|Actinobacteria	S	SURF1-like protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	SURF1
TLS3_k127_3611536_2	1193181.BN10_1080028	1.02e-280	876.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FFUG@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_3611536_3	1385518.N798_14920	7.564e-280	867.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4FESG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
TLS3_k127_3611536_9	367299.JOEE01000005_gene3608	3.289e-134	433.0	COG2321@1|root,COG2321@2|Bacteria,2H3UT@201174|Actinobacteria,4FFIT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
TLS3_k127_3611536_13	1385519.N801_11575	2.048e-61	219.0	COG1503@1|root,COG1503@2|Bacteria,2IFQH@201174|Actinobacteria,4FGXH@85021|Intrasporangiaceae	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3611536_15	367299.JOEE01000005_gene3604	1.26e-56	205.0	COG2151@1|root,COG2151@2|Bacteria,2IKUH@201174|Actinobacteria,4FGZ7@85021|Intrasporangiaceae	201174|Actinobacteria	S	metal-sulfur cluster biosynthetic enzyme	yitW	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
TLS3_k127_3611536_14	1385519.N801_11565	3.49e-61	228.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4FGNY@85021|Intrasporangiaceae	201174|Actinobacteria	C	SUF system FeS assembly protein, NifU family	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
TLS3_k127_3611536_5	367299.JOEE01000005_gene3602	5.31e-196	625.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4FETM@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
TLS3_k127_3611536_8	1385518.N798_14880	4.49e-139	446.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4FESX@85021|Intrasporangiaceae	201174|Actinobacteria	O	Iron ABC transporter ATP-binding protein	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
TLS3_k127_3611536_16	1385521.N803_08455	3.119e-46	173.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4FGX6@85021|Intrasporangiaceae	201174|Actinobacteria	P	ferredoxin	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
TLS3_k127_3611536_6	1043205.AFYF01000075_gene2042	5.118e-186	588.0	COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria,4FF87@85021|Intrasporangiaceae	201174|Actinobacteria	O	ABC transporter (Permease)	sufD	GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
TLS3_k127_3611536_1	1385518.N798_14865	2.009e-288	887.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4FEEZ@85021|Intrasporangiaceae	201174|Actinobacteria	O	Fe-S cluster assembly	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS3_k127_3639930_10	1172188.KB911821_gene2060	7.206e-111	371.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,4FETU@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
TLS3_k127_3639930_13	448385.sce1134	5.285e-62	231.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,42PIX@68525|delta/epsilon subdivisions,2WJRF@28221|Deltaproteobacteria,2Z3J9@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	cysT	-	-	ko:K02018,ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00189,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5,3.A.1.8	-	-	BPD_transp_1
TLS3_k127_3639930_15	1193181.BN10_690030	2.281e-53	202.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4FEYN@85021|Intrasporangiaceae	201174|Actinobacteria	P	molybdate-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
TLS3_k127_3639930_16	1193181.BN10_690029	6.314e-52	187.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4FGPS@85021|Intrasporangiaceae	201174|Actinobacteria	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
TLS3_k127_3639930_0	1298863.AUEP01000001_gene817	1.015e-319	1006.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4DNMK@85009|Propionibacteriales	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	VWA_2
TLS3_k127_3639930_2	196162.Noca_0952	4.265e-239	745.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4DPK8@85009|Propionibacteriales	201174|Actinobacteria	H	Mg-chelatase subunit ChlI	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
TLS3_k127_3639930_3	1122622.ATWJ01000001_gene2548	5.693e-197	623.0	COG2114@1|root,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria,4FF4J@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
TLS3_k127_3639930_1	1122622.ATWJ01000001_gene2549	2.695e-259	813.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FF74@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS3_k127_3639930_7	95619.PM1_0221415	1.187e-125	408.0	COG0596@1|root,COG0596@2|Bacteria,1MVTG@1224|Proteobacteria,1RQ1B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	3.7.1.9	ko:K10216	ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R02604,R05362,R05865	RC00272,RC00753,RC00754,RC00755,RC01337,RC01485	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
TLS3_k127_3639930_8	1193181.BN10_690028	6.212e-116	385.0	COG2755@1|root,COG2755@2|Bacteria,2GNBP@201174|Actinobacteria,4FFST@85021|Intrasporangiaceae	201174|Actinobacteria	E	G-D-S-L family lipolytic protein	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS3_k127_3639930_9	313589.JNB_16539	5.134e-115	380.0	COG0692@1|root,COG0692@2|Bacteria,2GJ9Z@201174|Actinobacteria,4FEUP@85021|Intrasporangiaceae	201174|Actinobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS3_k127_3639930_5	1193181.BN10_1690003	1.763e-185	598.0	COG0520@1|root,COG0520@2|Bacteria,2GKAF@201174|Actinobacteria,4FFPW@85021|Intrasporangiaceae	201174|Actinobacteria	E	Cysteine desulfurase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS3_k127_3639930_18	1385518.N798_00115	1.214e-39	156.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4FHH4@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS3_k127_3639930_4	1184609.KILIM_026_00310	2.28e-192	608.0	COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria,4F7QT@85018|Dermatophilaceae	201174|Actinobacteria	P	Sodium Bile acid symporter family	arsB	-	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	-	SBF
TLS3_k127_3639930_14	1210046.B277_11070	2.351e-61	229.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4FGNA@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS3_k127_3639930_17	1184609.KILIM_055_00290	7.967e-47	183.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,LMWPc
TLS3_k127_3639930_12	367299.JOEE01000006_gene820	2.226e-81	278.0	COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria,4FGUD@85021|Intrasporangiaceae	201174|Actinobacteria	S	HAD family hydrolase	-	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
TLS3_k127_3639930_19	1193181.BN10_690024	5.513e-34	134.0	2CUM0@1|root,32SVJ@2|Bacteria,2IQG7@201174|Actinobacteria,4FH91@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3263
TLS3_k127_3639930_11	1386089.N865_04330	2.009e-86	304.0	COG3191@1|root,COG3191@2|Bacteria,2GJKQ@201174|Actinobacteria,4FE8D@85021|Intrasporangiaceae	201174|Actinobacteria	EQ	Peptidase family S58	dmpA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
TLS3_k127_3639930_6	367299.JOEE01000006_gene827	1.893e-175	554.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4FF92@85021|Intrasporangiaceae	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
TLS3_k127_3667866_19	1386089.N865_09685	1.734e-29	118.0	COG3382@1|root,COG3382@2|Bacteria,2GMX2@201174|Actinobacteria,4FGG8@85021|Intrasporangiaceae	201174|Actinobacteria	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
TLS3_k127_3667866_13	1184609.KILIM_075_00220	6.078e-83	286.0	COG5015@1|root,COG5015@2|Bacteria,2I3I5@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS3_k127_3667866_10	367299.JOEE01000008_gene573	2.966e-101	336.0	COG3342@1|root,COG3342@2|Bacteria,2HWBG@201174|Actinobacteria,4FFQ6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
TLS3_k127_3667866_15	110319.CF8_2182	3.394e-73	254.0	COG0526@1|root,COG0607@1|root,COG0526@2|Bacteria,COG0607@2|Bacteria,2IKP1@201174|Actinobacteria,4DRIP@85009|Propionibacteriales	201174|Actinobacteria	CO	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
TLS3_k127_3667866_1	1416759.AYMR01000026_gene3428	3.347e-151	495.0	COG0596@1|root,COG0596@2|Bacteria,2H4IZ@201174|Actinobacteria,4FTRM@85023|Microbacteriaceae	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_3667866_14	1416759.AYMR01000026_gene3429	7.676e-77	270.0	COG2267@1|root,COG2267@2|Bacteria,2I7IU@201174|Actinobacteria,4FTRK@85023|Microbacteriaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
TLS3_k127_3667866_8	1120958.AULD01000007_gene1037	1.586e-112	370.0	COG1028@1|root,COG1028@2|Bacteria,2GJIH@201174|Actinobacteria,4FMU8@85023|Microbacteriaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	bdhA	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
TLS3_k127_3667866_16	1120958.AULD01000007_gene1036	3.549e-72	267.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	MA20_14935	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_3667866_0	1120958.AULD01000007_gene1035	8.069e-160	520.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FQXA@85023|Microbacteriaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_3667866_4	1120958.AULD01000007_gene1034	2.848e-136	459.0	COG4177@1|root,COG4177@2|Bacteria,2GNZK@201174|Actinobacteria,4FQYH@85023|Microbacteriaceae	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_3667866_5	1120958.AULD01000007_gene1033	4.372e-132	434.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4FPHI@85023|Microbacteriaceae	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
TLS3_k127_3667866_12	1120958.AULD01000007_gene1032	5.268e-95	322.0	COG0410@1|root,COG0410@2|Bacteria,2I93D@201174|Actinobacteria,4FQUM@85023|Microbacteriaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
TLS3_k127_3667866_7	1120958.AULD01000007_gene1031	1.458e-116	380.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4FPQK@85023|Microbacteriaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
TLS3_k127_3667866_2	1120958.AULD01000007_gene1030	4.3e-150	485.0	COG0683@1|root,COG0683@2|Bacteria,2HYHD@201174|Actinobacteria,4FQIX@85023|Microbacteriaceae	201174|Actinobacteria	E	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
TLS3_k127_3667866_3	1122622.ATWJ01000002_gene802	6.779e-137	455.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4FGI2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
TLS3_k127_3667866_17	1380356.JNIK01000003_gene1245	6.747e-45	182.0	COG4119@1|root,COG4119@2|Bacteria,2IM6D@201174|Actinobacteria,4ET4C@85013|Frankiales	201174|Actinobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_3667866_6	1247726.MIM_c03940	5.99e-131	435.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VNZF@28216|Betaproteobacteria,3T98G@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	caiB	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
TLS3_k127_3667866_20	1240349.ANGC01000007_gene1215	6.529e-27	122.0	COG1266@1|root,COG1266@2|Bacteria,2GKRA@201174|Actinobacteria,4FW8W@85025|Nocardiaceae	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS3_k127_3667866_18	118168.MC7420_3663	1.175e-32	146.0	COG1266@1|root,COG1266@2|Bacteria,1GBRH@1117|Cyanobacteria,1HEWU@1150|Oscillatoriales	1117|Cyanobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
TLS3_k127_3667866_9	880073.Calab_3281	1.55e-110	376.0	COG1680@1|root,COG1680@2|Bacteria,2NNSA@2323|unclassified Bacteria	2|Bacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_3667866_11	797209.ZOD2009_00215	1.05e-96	331.0	arCOG09388@1|root,arCOG09388@2157|Archaea,2XUZY@28890|Euryarchaeota,23USW@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3667866_21	926569.ANT_13160	6.029e-20	104.0	COG1664@1|root,COG1664@2|Bacteria,2G7EZ@200795|Chloroflexi	200795|Chloroflexi	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
TLS3_k127_3667866_22	1380370.JIBA01000007_gene3979	3.005e-12	66.0	2E62U@1|root,330RX@2|Bacteria,2GTSM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_36754_19	1385520.N802_03830	7.662e-52	190.0	COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria,4FHC7@85021|Intrasporangiaceae	201174|Actinobacteria	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
TLS3_k127_36754_17	1385520.N802_03835	5.548e-55	201.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4FH5E@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	litS	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
TLS3_k127_36754_21	1385520.N802_03840	1.422e-43	171.0	COG5343@1|root,COG5343@2|Bacteria,2IM7X@201174|Actinobacteria,4FHJ6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
TLS3_k127_36754_4	1385518.N798_02265	3.273e-201	633.0	COG1960@1|root,COG1960@2|Bacteria,2GNBW@201174|Actinobacteria,4FERF@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE23	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS3_k127_36754_5	710696.Intca_2386	6.022e-149	485.0	COG1960@1|root,COG1960@2|Bacteria,2GJH2@201174|Actinobacteria,4FG10@85021|Intrasporangiaceae	201174|Actinobacteria	I	Dehydrogenase	fadE24	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_36754_14	1304865.JAGF01000001_gene2446	1.755e-75	265.0	29JD5@1|root,306AN@2|Bacteria,2I9J8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_36754_12	1304865.JAGF01000001_gene2445	2.589e-82	284.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_36754_25	316057.RPD_1176	0.0004861	48.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2UFCQ@28211|Alphaproteobacteria,3K1FC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	HupF/HypC family	hypC	-	-	ko:K04653,ko:K04656	-	-	-	-	ko00000	-	-	-	HupF_HypC
TLS3_k127_36754_23	1304865.JAGF01000001_gene2443	1.347e-26	126.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hoxW	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
TLS3_k127_36754_3	1043493.BBLU01000015_gene1111	6.606e-203	650.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria	201174|Actinobacteria	C	PFAM Nickel-dependent hydrogenase, large subunit	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
TLS3_k127_36754_8	1043493.BBLU01000015_gene1112	3.174e-123	402.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
TLS3_k127_36754_9	1304865.JAGF01000001_gene2440	6.983e-118	395.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria	201174|Actinobacteria	CH	Oxidoreductase	asrB	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
TLS3_k127_36754_20	518766.Rmar_2587	4.266e-46	171.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
TLS3_k127_36754_6	1304865.JAGF01000001_gene2439	2.075e-146	475.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
TLS3_k127_36754_0	367299.JOEE01000008_gene500	0.0	1074.0	COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4FG28@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
TLS3_k127_36754_1	1043205.AFYF01000083_gene1874	1.085e-302	935.0	COG4147@1|root,COG4147@2|Bacteria,2GJ56@201174|Actinobacteria,4FIQ7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Sodium:solute symporter family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TLS3_k127_36754_22	1123251.ATWM01000010_gene2987	4.056e-36	139.0	COG4327@1|root,COG4327@2|Bacteria,2IRIC@201174|Actinobacteria,4FJA9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4212)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
TLS3_k127_36754_24	1122622.ATWJ01000002_gene832	7.19e-24	109.0	2E13N@1|root,32WJ1@2|Bacteria,2IRAG@201174|Actinobacteria,4FJIC@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_36754_16	1123258.AQXZ01000019_gene2779	8.325e-57	210.0	COG0500@1|root,COG2226@2|Bacteria,2IDCB@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_36754_2	1385520.N802_03045	1.602e-237	762.0	COG0558@1|root,COG0558@2|Bacteria,2I5BP@201174|Actinobacteria,4FEZT@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf,Sulfatase
TLS3_k127_36754_11	1385520.N802_03055	3.952e-92	308.0	COG1985@1|root,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,4FFDX@85021|Intrasporangiaceae	201174|Actinobacteria	H	RibD C-terminal domain	ribG	-	1.1.1.193,3.5.4.26	ko:K00082,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
TLS3_k127_36754_15	1464048.JNZS01000018_gene2106	1.514e-65	241.0	COG0392@1|root,COG0392@2|Bacteria,2GP8H@201174|Actinobacteria,4DB6J@85008|Micromonosporales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS3_k127_36754_13	471852.Tcur_2748	1.29e-81	282.0	COG4106@1|root,COG4106@2|Bacteria,2I37U@201174|Actinobacteria,4EMMT@85012|Streptosporangiales	201174|Actinobacteria	S	trans-aconitate 2-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_36754_10	1386089.N865_02680	3.61e-98	334.0	COG0438@1|root,COG0438@2|Bacteria,2GYA2@201174|Actinobacteria,4FG9B@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_36754_18	1385520.N802_03075	7.536e-55	194.0	COG0720@1|root,COG0720@2|Bacteria,2II5D@201174|Actinobacteria,4FH3Q@85021|Intrasporangiaceae	201174|Actinobacteria	H	6-pyruvoyl tetrahydropterin synthase	ptpS	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
TLS3_k127_36754_7	1386089.N865_02690	1.475e-138	457.0	COG1063@1|root,COG1063@2|Bacteria,2GKU2@201174|Actinobacteria,4FG3Z@85021|Intrasporangiaceae	201174|Actinobacteria	E	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH_N
TLS3_k127_3771563_19	1385520.N802_15960	7.956e-27	111.0	COG1051@1|root,COG1051@2|Bacteria,2GPP2@201174|Actinobacteria,4FGWP@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_3771563_17	367299.JOEE01000007_gene83	1.838e-41	171.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4FH64@85021|Intrasporangiaceae	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
TLS3_k127_3771563_4	367299.JOEE01000007_gene82	3.893e-127	422.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4FF16@85021|Intrasporangiaceae	201174|Actinobacteria	KT	PspC domain	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
TLS3_k127_3771563_8	1385520.N802_15980	3.877e-114	372.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4FEB1@85021|Intrasporangiaceae	201174|Actinobacteria	K	LuxR family transcriptional regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_3771563_16	710696.Intca_3472	4.138e-43	166.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4FGUK@85021|Intrasporangiaceae	201174|Actinobacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
TLS3_k127_3771563_11	1043205.AFYF01000009_gene1518	8.389e-66	229.0	2A5WC@1|root,30UNA@2|Bacteria,2H8VG@201174|Actinobacteria,4FJDQ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3771563_13	1385518.N798_07570	1.491e-60	226.0	COG2197@1|root,COG2197@2|Bacteria,2GUV9@201174|Actinobacteria,4FJN4@85021|Intrasporangiaceae	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
TLS3_k127_3771563_18	1193181.BN10_80003	4.438e-37	142.0	2EVGU@1|root,33NX7@2|Bacteria,2I855@201174|Actinobacteria,4FK3F@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3771563_7	367299.JOEE01000007_gene79	2.985e-118	388.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4FEJP@85021|Intrasporangiaceae	201174|Actinobacteria	C	Quinone oxidoreductase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_3771563_10	1193181.BN10_110005	5.95e-102	338.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4FGF3@85021|Intrasporangiaceae	201174|Actinobacteria	S	LmbE family	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS3_k127_3771563_5	1184609.KILIM_029_00030	1.114e-123	421.0	COG4425@1|root,COG4425@2|Bacteria,2GKB5@201174|Actinobacteria,4F7GE@85018|Dermatophilaceae	201174|Actinobacteria	S	Alpha/beta-hydrolase family N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_9,Abhydrolase_9_N
TLS3_k127_3771563_2	1193181.BN10_1280006	1.96e-187	588.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4FEZ7@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA ligase	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
TLS3_k127_3771563_14	1385518.N798_10725	3.094e-58	214.0	COG3832@1|root,COG3832@2|Bacteria,2IFJT@201174|Actinobacteria,4FGZW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_3771563_0	1193181.BN10_1280001	0.0	1232.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4FFG4@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
TLS3_k127_3771563_15	367299.JOEE01000007_gene69	1.647e-50	191.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4FG0U@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidase family M23	envC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_3771563_6	1385518.N798_05285	9.966e-121	397.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria,4FFRU@85021|Intrasporangiaceae	201174|Actinobacteria	S	with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF676,PGAP1
TLS3_k127_3771563_12	1386089.N865_03370	4.451e-62	220.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4FGQ3@85021|Intrasporangiaceae	201174|Actinobacteria	I	B12 binding domain	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
TLS3_k127_3771563_9	367299.JOEE01000003_gene3044	3.844e-112	376.0	COG0524@1|root,COG0524@2|Bacteria,2IA3T@201174|Actinobacteria,4FFSE@85021|Intrasporangiaceae	201174|Actinobacteria	G	Sugar kinase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH,PfkB
TLS3_k127_3771563_1	367299.JOEE01000007_gene66	4.379e-208	653.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4FEAI@85021|Intrasporangiaceae	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
TLS3_k127_3771563_3	1210046.B277_01744	8.803e-162	518.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4FFWQ@85021|Intrasporangiaceae	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
TLS3_k127_3786942_4	1122602.ATXP01000010_gene461	5.953e-141	451.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,1W7ZJ@1268|Micrococcaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
TLS3_k127_3786942_2	1043205.AFYF01000081_gene1839	1.796e-204	642.0	COG0156@1|root,COG0156@2|Bacteria,2GISV@201174|Actinobacteria,4FEEP@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_3786942_3	1122622.ATWJ01000014_gene259	1.384e-194	619.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4FED3@85021|Intrasporangiaceae	201174|Actinobacteria	E	L-threonine 3-dehydrogenase	tdh	-	1.1.1.103,1.1.1.380	ko:K00060,ko:K08322	ko00040,ko00260,ko01100,map00040,map00260,map01100	-	R01465,R10848	RC00085,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_3786942_1	1121933.AUHH01000024_gene2956	1.124e-211	667.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4DT4F@85009|Propionibacteriales	201174|Actinobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	zwf1	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS3_k127_3786942_6	1385518.N798_11500	4.235e-18	89.0	COG5340@1|root,COG5340@2|Bacteria,2II40@201174|Actinobacteria,4FGPX@85021|Intrasporangiaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS3_k127_3786942_7	367299.JOEE01000006_gene706	4.489e-07	54.0	COG5340@1|root,COG5340@2|Bacteria,2II40@201174|Actinobacteria,4FGPX@85021|Intrasporangiaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS3_k127_3786942_5	1122138.AQUZ01000045_gene4479	4.472e-56	199.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,4DQM6@85009|Propionibacteriales	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS3_k127_3786942_0	1184609.KILIM_029_00330	0.0	1167.0	COG0376@1|root,COG0376@2|Bacteria,2GJFP@201174|Actinobacteria	201174|Actinobacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
TLS3_k127_3796847_9	367299.JOEE01000003_gene2914	3.349e-37	153.0	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4FF4U@85021|Intrasporangiaceae	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Yop-YscD_cpl
TLS3_k127_3796847_0	479431.Namu_3802	9.738e-264	830.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4EREJ@85013|Frankiales	201174|Actinobacteria	J	elongation factor G domain IV	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
TLS3_k127_3796847_1	1385519.N801_13690	7.449e-212	664.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4FEUS@85021|Intrasporangiaceae	201174|Actinobacteria	U	Flp pilus assembly protein ATPase CpaF	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
TLS3_k127_3796847_4	1385521.N803_01955	1.125e-104	347.0	COG2064@1|root,COG2064@2|Bacteria,2GKMW@201174|Actinobacteria,4FENF@85021|Intrasporangiaceae	201174|Actinobacteria	NU	type II secretion system protein	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS3_k127_3796847_3	313589.JNB_06644	3.433e-115	383.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4FE9I@85021|Intrasporangiaceae	201174|Actinobacteria	NU	pilus assembly protein	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
TLS3_k127_3796847_10	1385520.N802_02010	7.174e-36	140.0	2CXFQ@1|root,32T1V@2|Bacteria,2GQYH@201174|Actinobacteria,4FHJ8@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pilus biosynthesis protein TadE	-	-	-	-	-	-	-	-	-	-	-	-	TadE
TLS3_k127_3796847_8	1385521.N803_01935	5.729e-44	171.0	2E9Y4@1|root,3343S@2|Bacteria,2GR3H@201174|Actinobacteria,4FHBJ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3796847_11	1193181.BN10_1230007	1.246e-18	97.0	2EBSZ@1|root,335SP@2|Bacteria,2IS2J@201174|Actinobacteria,4FH9T@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tad
TLS3_k127_3796847_2	446468.Ndas_0391	1.754e-140	458.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4EFZS@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_3796847_7	1210046.B277_03655	1.807e-64	234.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,2HXQA@201174|Actinobacteria,4FHIS@85021|Intrasporangiaceae	201174|Actinobacteria	K	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2,MerR_1
TLS3_k127_3796847_6	1121928.AUHE01000001_gene1666	2.422e-95	327.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4GARK@85026|Gordoniaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_3796847_5	43354.JOIJ01000003_gene3929	1.91e-95	327.0	COG3387@1|root,COG3387@2|Bacteria,2GKU7@201174|Actinobacteria,4E263@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
TLS3_k127_3873457_7	644548.SCNU_12382	2.925e-20	91.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4GEAI@85026|Gordoniaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_3873457_1	1077974.GOEFS_019_00060	4.616e-73	252.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,4GB6X@85026|Gordoniaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
TLS3_k127_3873457_2	935866.JAER01000052_gene2861	1.944e-68	246.0	COG1576@1|root,COG1576@2|Bacteria,2I3MI@201174|Actinobacteria,4DQMN@85009|Propionibacteriales	201174|Actinobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,MDMPI_N
TLS3_k127_3873457_3	2045.KR76_06035	3.198e-50	185.0	2AEJC@1|root,314EV@2|Bacteria,2GMTI@201174|Actinobacteria,4DRFK@85009|Propionibacteriales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
TLS3_k127_3873457_5	2045.KR76_06040	1.009e-37	158.0	COG1846@1|root,COG1846@2|Bacteria,2IHTR@201174|Actinobacteria,4DRP8@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR_2
TLS3_k127_3873457_0	1385519.N801_08790	5.547e-139	450.0	COG3250@1|root,COG3250@2|Bacteria,2HFCB@201174|Actinobacteria,4FIJ1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
TLS3_k127_3873457_6	1385519.N801_08790	2.042e-28	114.0	COG3250@1|root,COG3250@2|Bacteria,2HFCB@201174|Actinobacteria,4FIJ1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
TLS3_k127_3873457_4	196162.Noca_2498	7.56e-48	177.0	COG4405@1|root,COG4405@2|Bacteria,2I5BR@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
TLS3_k127_3882417_29	367299.JOEE01000004_gene1340	4.93e-26	122.0	29NZS@1|root,309XX@2|Bacteria,2GV4I@201174|Actinobacteria,4FHUG@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3882417_13	1385521.N803_09100	2.158e-146	481.0	COG0520@1|root,COG0520@2|Bacteria,2GMIC@201174|Actinobacteria,4FFF7@85021|Intrasporangiaceae	201174|Actinobacteria	E	Cysteine desulfurase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
TLS3_k127_3882417_0	1385518.N798_09185	0.0	1656.0	COG1643@1|root,COG1643@2|Bacteria,2GIWX@201174|Actinobacteria,4FEPI@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
TLS3_k127_3882417_17	1385519.N801_04425	4.484e-125	425.0	COG2047@1|root,COG2047@2|Bacteria,2GK8I@201174|Actinobacteria,4FFY0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Proteasome assembly chaperone 2	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS3_k127_3882417_6	1210046.B277_04000	1.177e-191	616.0	COG0749@1|root,COG0749@2|Bacteria,2GM8R@201174|Actinobacteria,4FFYJ@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA polymerase I	polA2	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_pol_A
TLS3_k127_3882417_19	1385521.N803_05770	6.01e-83	281.0	28MIG@1|root,2ZAV8@2|Bacteria,2IJSH@201174|Actinobacteria,4FECP@85021|Intrasporangiaceae	201174|Actinobacteria	S	EcsC protein family	-	-	-	-	-	-	-	-	-	-	-	-	EcsC
TLS3_k127_3882417_27	1385521.N803_05765	2.942e-30	126.0	COG3339@1|root,COG3339@2|Bacteria,2GQGT@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
TLS3_k127_3882417_30	1386089.N865_20010	2.74e-25	119.0	2AR9G@1|root,31GJC@2|Bacteria,2I11I@201174|Actinobacteria,4FHHJ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4192
TLS3_k127_3882417_33	1193181.BN10_300036	0.0001924	46.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4FEYH@85021|Intrasporangiaceae	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS3_k127_3882417_15	1386089.N865_01995	1.605e-134	441.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4FEYH@85021|Intrasporangiaceae	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
TLS3_k127_3882417_24	710696.Intca_1504	8.915e-36	141.0	COG0589@1|root,COG0589@2|Bacteria,2IR3G@201174|Actinobacteria,4FGQB@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_3882417_2	1385519.N801_04390	6.54e-203	649.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4FEWS@85021|Intrasporangiaceae	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
TLS3_k127_3882417_12	1385520.N802_10305	1.026e-149	504.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4FE68@85021|Intrasporangiaceae	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
TLS3_k127_3882417_18	1385518.N798_09135	9.004e-108	362.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4FFZY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
TLS3_k127_3882417_11	367299.JOEE01000004_gene1352	1.084e-150	484.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4FFI4@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS3_k127_3882417_22	1386089.N865_02035	2.489e-59	208.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4FGK3@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
TLS3_k127_3882417_16	1193181.BN10_300045	9.425e-126	414.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4FETT@85021|Intrasporangiaceae	201174|Actinobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
TLS3_k127_3882417_31	1193181.BN10_300046	2.31e-24	109.0	COG2919@1|root,COG2919@2|Bacteria,2GTFA@201174|Actinobacteria,4FK1H@85021|Intrasporangiaceae	201174|Actinobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3882417_4	1385519.N801_15240	9.282e-198	638.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4FFSS@85021|Intrasporangiaceae	201174|Actinobacteria	D	cell division protein FtsI	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
TLS3_k127_3882417_7	313589.JNB_00620	1.197e-181	581.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4FFK3@85021|Intrasporangiaceae	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_3882417_8	367299.JOEE01000004_gene1358	8.584e-157	529.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4FEIC@85021|Intrasporangiaceae	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_3882417_5	1385521.N803_06580	1.298e-193	610.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4FEX5@85021|Intrasporangiaceae	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
TLS3_k127_3882417_1	367299.JOEE01000004_gene1360	8.528e-213	672.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4FEIE@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
TLS3_k127_3882417_10	1385519.N801_15265	8.963e-153	494.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4FEC0@85021|Intrasporangiaceae	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
TLS3_k127_3882417_14	1385518.N798_14385	9.335e-135	451.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4FEZH@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS3_k127_3882417_9	367299.JOEE01000004_gene1363	3.074e-156	507.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4FE62@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_3882417_28	710696.Intca_1521	1.879e-29	129.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4FGF1@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
TLS3_k127_3882417_3	313589.JNB_00660	8.654e-199	625.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4FE51@85021|Intrasporangiaceae	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
TLS3_k127_3882417_21	313589.JNB_00665	6.547e-69	252.0	COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria,4FFF8@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
TLS3_k127_3882417_20	1172188.KB911824_gene3457	1.635e-72	252.0	COG0325@1|root,COG0325@2|Bacteria,2GMRJ@201174|Actinobacteria,4FG49@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
TLS3_k127_3882417_23	1385521.N803_06625	1.681e-49	185.0	COG1799@1|root,COG1799@2|Bacteria,2GNVH@201174|Actinobacteria,4FFP8@85021|Intrasporangiaceae	201174|Actinobacteria	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
TLS3_k127_3882417_25	313589.JNB_00680	5.468e-33	133.0	COG0762@1|root,COG0762@2|Bacteria,2GQI1@201174|Actinobacteria,4FHVS@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
TLS3_k127_3882417_26	367299.JOEE01000004_gene1370	6.901e-31	131.0	COG3599@1|root,COG3599@2|Bacteria,2GMSC@201174|Actinobacteria,4FG4W@85021|Intrasporangiaceae	201174|Actinobacteria	D	DivIVA protein	wag31	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS3_k127_3928708_9	557599.MKAN_19030	7.849e-104	351.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,236TQ@1762|Mycobacteriaceae	201174|Actinobacteria	S	phosphoribosyl transferase	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
TLS3_k127_3928708_18	1385518.N798_06450	1.178e-25	108.0	2E39N@1|root,32Y97@2|Bacteria,2GQFF@201174|Actinobacteria,4FHRB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3117
TLS3_k127_3928708_10	710696.Intca_2598	6.178e-100	332.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4FJE7@85021|Intrasporangiaceae	201174|Actinobacteria	I	enoyl-CoA hydratase	chcB	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
TLS3_k127_3928708_11	1121017.AUFG01000003_gene3419	2.66e-85	298.0	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria,4FEMA@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
TLS3_k127_3928708_17	1385518.N798_06435	6.853e-34	134.0	COG3427@1|root,COG3427@2|Bacteria,2HXJU@201174|Actinobacteria,4FH7T@85021|Intrasporangiaceae	201174|Actinobacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_3928708_19	1045009.AFXQ01000012_gene401	7.887e-12	73.0	COG3599@1|root,COG3599@2|Bacteria,2I575@201174|Actinobacteria,1WAAG@1268|Micrococcaceae	201174|Actinobacteria	D	regulation of cell shape	-	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS3_k127_3928708_8	1380370.JIBA01000011_gene3317	1.898e-105	361.0	COG0510@1|root,COG0510@2|Bacteria	2|Bacteria	M	ethanolamine kinase activity	-	-	2.7.1.89	ko:K07251	ko00730,ko01100,map00730,map01100	-	R02134	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	APH,Choline_kinase
TLS3_k127_3928708_7	1385518.N798_06425	3.041e-111	376.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4FEFV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the LOG family	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
TLS3_k127_3928708_5	1385520.N802_07540	3.751e-157	512.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,4FEKF@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_3928708_6	367299.JOEE01000011_gene3200	1.433e-153	489.0	COG2171@1|root,COG2171@2|Bacteria,2GIZ9@201174|Actinobacteria,4FENI@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA	dapD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1201c	Hexapep_2,THDPS_M
TLS3_k127_3928708_12	1210046.B277_00065	3.264e-77	273.0	COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4FGEK@85021|Intrasporangiaceae	201174|Actinobacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3928708_1	1193181.BN10_130013	1.781e-237	740.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4FEQ1@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
TLS3_k127_3928708_2	367299.JOEE01000011_gene3197	1.249e-182	584.0	COG0436@1|root,COG0436@2|Bacteria,2GJMI@201174|Actinobacteria,4FEFM@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase	dapC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
TLS3_k127_3928708_14	1385518.N798_06390	4.8e-69	236.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,4FGN1@85021|Intrasporangiaceae	201174|Actinobacteria	C	ferredoxin	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4
TLS3_k127_3928708_13	367299.JOEE01000011_gene3195	6.273e-71	256.0	COG0454@1|root,COG0456@2|Bacteria,2H5WU@201174|Actinobacteria,4FGPF@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase	-	-	2.3.1.1	ko:K22476	ko00220,ko01210,ko01230,map00220,map01210,map01230	-	R00259	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,FR47
TLS3_k127_3928708_4	1385519.N801_05910	7.512e-158	517.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4FFQF@85021|Intrasporangiaceae	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
TLS3_k127_3928708_15	367299.JOEE01000011_gene3192	2.317e-47	179.0	COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria,4FH34@85021|Intrasporangiaceae	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
TLS3_k127_3928708_3	367299.JOEE01000011_gene3190	5.554e-175	570.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4FEG1@85021|Intrasporangiaceae	201174|Actinobacteria	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS3_k127_3928708_0	1385521.N803_03050	0.0	1078.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4FEJF@85021|Intrasporangiaceae	201174|Actinobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
TLS3_k127_3928708_16	1385521.N803_03055	2.097e-37	147.0	COG0494@1|root,COG0494@2|Bacteria,2I2GY@201174|Actinobacteria,4FH1K@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS3_k127_3970369_16	367299.JOEE01000001_gene1604	3.064e-61	218.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4FHAM@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
TLS3_k127_3970369_24	1200352.A606_05570	1.538e-19	89.0	2EGTM@1|root,33AJR@2|Bacteria,2GWY1@201174|Actinobacteria,22PJQ@1653|Corynebacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3970369_19	367299.JOEE01000001_gene1598	1.74e-49	181.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,4FJZB@85021|Intrasporangiaceae	201174|Actinobacteria	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
TLS3_k127_3970369_23	1193181.BN10_540072	5.061e-27	123.0	2BHT8@1|root,32BWW@2|Bacteria,2HKR9@201174|Actinobacteria,4FJE8@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510
TLS3_k127_3970369_9	1122622.ATWJ01000012_gene1057	3.718e-127	419.0	COG2354@1|root,COG2354@2|Bacteria,2GM9S@201174|Actinobacteria,4FENG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
TLS3_k127_3970369_21	1043205.AFYF01000072_gene2220	7.471e-40	153.0	2FGPG@1|root,348J2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3970369_2	367299.JOEE01000002_gene2522	6.77e-212	662.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,4FE3R@85021|Intrasporangiaceae	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS3_k127_3970369_12	1122622.ATWJ01000011_gene2294	2.003e-92	309.0	COG0640@1|root,COG0640@2|Bacteria,2I8I0@201174|Actinobacteria,4FH0V@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_3970369_6	1122622.ATWJ01000011_gene2295	7.866e-188	599.0	COG0477@1|root,COG2814@2|Bacteria,2I8QF@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS3_k127_3970369_4	367299.JOEE01000002_gene2549	1.192e-193	626.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4FFXE@85021|Intrasporangiaceae	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
TLS3_k127_3970369_7	1385518.N798_13985	1.121e-142	460.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4FEJR@85021|Intrasporangiaceae	201174|Actinobacteria	P	Integral membrane protein TerC family	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS3_k127_3970369_17	1385518.N798_07265	3.066e-58	228.0	COG2197@1|root,COG2197@2|Bacteria,2IJB1@201174|Actinobacteria,4FGXB@85021|Intrasporangiaceae	201174|Actinobacteria	K	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_3970369_11	1193181.BN10_690009	6.812e-103	347.0	COG1960@1|root,COG1960@2|Bacteria,2GKK2@201174|Actinobacteria,4FGHY@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_M
TLS3_k127_3970369_10	1193181.BN10_690011	1.471e-120	419.0	COG2120@1|root,COG4976@1|root,COG2120@2|Bacteria,COG4976@2|Bacteria,2IA7G@201174|Actinobacteria,4FGFF@85021|Intrasporangiaceae	201174|Actinobacteria	M	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,NodS,PIG-L
TLS3_k127_3970369_8	1122622.ATWJ01000013_gene217	4.237e-137	441.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4FF2M@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
TLS3_k127_3970369_20	1122622.ATWJ01000008_gene2814	3.17e-49	194.0	COG2518@1|root,COG2518@2|Bacteria,2HXGI@201174|Actinobacteria,4FGK8@85021|Intrasporangiaceae	201174|Actinobacteria	O	Protein-L-isoaspartate carboxylmethyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
TLS3_k127_3970369_22	313589.JNB_11134	3.207e-37	152.0	COG1309@1|root,COG1309@2|Bacteria,2IK0Z@201174|Actinobacteria,4FI53@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_3970369_5	1385521.N803_15475	6.476e-192	605.0	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4FIUA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_3970369_15	1122622.ATWJ01000014_gene308	1.469e-64	235.0	2E743@1|root,331NI@2|Bacteria,2GQFR@201174|Actinobacteria,4FHNZ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3970369_18	1122622.ATWJ01000014_gene309	2.646e-52	187.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria,4FHIG@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
TLS3_k127_3970369_0	1210046.B277_15013	0.0	1117.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
TLS3_k127_3970369_3	1210046.B277_15018	2.791e-208	653.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FFTE@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_3970369_1	512565.AMIS_40270	1.975e-234	738.0	COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria,4D9D4@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
TLS3_k127_3970369_13	1172188.KB911820_gene2317	1.864e-91	307.0	COG4912@1|root,COG4912@2|Bacteria,2GNQD@201174|Actinobacteria,4FE49@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA alkylation repair	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
TLS3_k127_3970369_14	367299.JOEE01000002_gene2293	1.785e-88	297.0	28P5T@1|root,2ZC0N@2|Bacteria,2GP34@201174|Actinobacteria,4FEI8@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3970369_25	298653.Franean1_1557	0.0001409	46.0	2CIG4@1|root,33C84@2|Bacteria,2GWMV@201174|Actinobacteria,4ETK6@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_3982349_1	1385518.N798_15460	1.554e-221	696.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4FE65@85021|Intrasporangiaceae	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
TLS3_k127_3982349_2	367299.JOEE01000003_gene2733	1.594e-201	645.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4FERU@85021|Intrasporangiaceae	201174|Actinobacteria	H	Folylpolyglutamate synthase	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
TLS3_k127_3982349_3	1385519.N801_17465	1.219e-125	416.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4FHDR@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_3982349_0	1122622.ATWJ01000009_gene3388	2.827e-225	708.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4FIWH@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS3_k127_3982349_5	1385521.N803_01150	1.347e-38	149.0	2EHND@1|root,33BE5@2|Bacteria,2I1BB@201174|Actinobacteria,4FH5S@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4233)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4233
TLS3_k127_3982349_4	1385520.N802_01230	3.732e-76	256.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4FGCH@85021|Intrasporangiaceae	201174|Actinobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
TLS3_k127_402047_0	1193181.BN10_680056	0.0	1042.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4FEI5@85021|Intrasporangiaceae	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
TLS3_k127_402047_7	1385518.N798_15995	1.281e-59	213.0	COG2050@1|root,COG2050@2|Bacteria,2IJGG@201174|Actinobacteria,4FGQQ@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
TLS3_k127_402047_5	367299.JOEE01000009_gene279	4.081e-92	320.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4FG0J@85021|Intrasporangiaceae	201174|Actinobacteria	T	protein tyrosine phosphatase	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
TLS3_k127_402047_1	1385518.N798_16020	7.412e-171	545.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4FESQ@85021|Intrasporangiaceae	201174|Actinobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	iNJ661.Rv2388c	HemN_C,Radical_SAM
TLS3_k127_402047_12	1123258.AQXZ01000019_gene2780	1.288e-29	123.0	COG3296@1|root,COG3296@2|Bacteria,2IQSV@201174|Actinobacteria,4G2UH@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
TLS3_k127_402047_11	593907.Celgi_1229	1.246e-29	126.0	COG3296@1|root,COG3296@2|Bacteria,2IQSV@201174|Actinobacteria,4F1HK@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
TLS3_k127_402047_4	1172188.KB911821_gene1222	1.956e-136	439.0	COG0613@1|root,COG0613@2|Bacteria,2GIZ5@201174|Actinobacteria,4FE9D@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3097
TLS3_k127_402047_3	367299.JOEE01000009_gene287	5.413e-148	477.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4FEFK@85021|Intrasporangiaceae	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
TLS3_k127_402047_2	313589.JNB_05020	1.661e-170	566.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4FFAW@85021|Intrasporangiaceae	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS3_k127_402047_6	367299.JOEE01000009_gene289	8.142e-83	281.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,4FEBN@85021|Intrasporangiaceae	201174|Actinobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
TLS3_k127_402047_8	1385520.N802_00660	1.016e-47	186.0	COG5401@1|root,COG5401@2|Bacteria,2IQ3Y@201174|Actinobacteria,4FH7Z@85021|Intrasporangiaceae	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
TLS3_k127_402047_9	196162.Noca_1908	8.922e-44	169.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria,4DRQQ@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_402047_10	570268.ANBB01000046_gene1390	8.78e-39	148.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4EJSG@85012|Streptosporangiales	201174|Actinobacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
TLS3_k127_4021471_1	1246995.AFR_18415	1.816e-289	904.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4DCD5@85008|Micromonosporales	201174|Actinobacteria	G	Alpha-galactosidase	aga	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
TLS3_k127_4021471_6	1246445.ANAY01000003_gene3156	4.714e-163	524.0	COG0477@1|root,COG2814@2|Bacteria,2I9K2@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_4021471_3	1114959.SZMC14600_10323	1.438e-201	640.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4DYBA@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
TLS3_k127_4021471_26	1123024.AUII01000023_gene262	1.793e-08	59.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
TLS3_k127_4021471_14	1121385.AQXW01000004_gene1555	4.909e-78	266.0	2C7PT@1|root,2ZCBY@2|Bacteria,2I886@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4021471_8	367299.JOEE01000001_gene1853	2.117e-129	421.0	COG1408@1|root,COG1408@2|Bacteria,2GJHT@201174|Actinobacteria,4FEHS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
TLS3_k127_4021471_17	367299.JOEE01000001_gene1854	8.887e-59	208.0	COG1610@1|root,COG1610@2|Bacteria,2IFFJ@201174|Actinobacteria,4FGNG@85021|Intrasporangiaceae	201174|Actinobacteria	S	GatB YqeY domain-containing protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS3_k127_4021471_2	1193181.BN10_1710007	9.502e-220	718.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4FERW@85021|Intrasporangiaceae	201174|Actinobacteria	M	Penicillin-binding Protein	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
TLS3_k127_4021471_21	367299.JOEE01000001_gene1856	3.877e-42	157.0	2CC1Y@1|root,32TCV@2|Bacteria,2IQEP@201174|Actinobacteria,4FHDV@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	wblA	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS3_k127_4021471_4	367299.JOEE01000001_gene1857	5.404e-173	555.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4FFB0@85021|Intrasporangiaceae	201174|Actinobacteria	P	Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS3_k127_4021471_10	313589.JNB_10094	9.262e-119	393.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4FFN1@85021|Intrasporangiaceae	201174|Actinobacteria	D	Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
TLS3_k127_4021471_23	266940.Krad_0427	1.053e-19	93.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
TLS3_k127_4021471_16	1121017.AUFG01000019_gene2407	2.382e-69	240.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4FGP9@85021|Intrasporangiaceae	201174|Actinobacteria	J	LysR family transcriptional regulator	yabJ	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
TLS3_k127_4021471_15	1121017.AUFG01000019_gene2408	2.326e-74	259.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4FGME@85021|Intrasporangiaceae	201174|Actinobacteria	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_4021471_7	1385518.N798_13150	2.362e-132	428.0	COG0491@1|root,COG0491@2|Bacteria,2GKP9@201174|Actinobacteria,4FEJY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	pksB_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
TLS3_k127_4021471_11	1385518.N798_13155	3.253e-115	375.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4FFBU@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_4021471_9	710696.Intca_0480	1.225e-125	409.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4FEGE@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS3_k127_4021471_13	1385518.N798_13170	2.18e-91	306.0	COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria,4FGAE@85021|Intrasporangiaceae	201174|Actinobacteria	L	Nudix hydrolase	nudL	-	-	ko:K18568	ko00332,ko01130,map00332,map01130	-	R10747	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
TLS3_k127_4021471_12	1121017.AUFG01000067_gene154	6.344e-96	323.0	COG2267@1|root,COG2267@2|Bacteria,2I2IM@201174|Actinobacteria,4FG81@85021|Intrasporangiaceae	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_4021471_19	1385521.N803_09850	1.425e-45	169.0	2DPPE@1|root,332VJ@2|Bacteria,2IN30@201174|Actinobacteria,4FGZI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
TLS3_k127_4021471_0	1193181.BN10_580047	0.0	1185.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4FFGY@85021|Intrasporangiaceae	201174|Actinobacteria	CP	Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	mnhB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,NADHdh,Proton_antipo_M,Proton_antipo_N
TLS3_k127_4021471_18	1193181.BN10_580046	4.291e-46	169.0	COG1006@1|root,COG1006@2|Bacteria,2IR2B@201174|Actinobacteria,4FHJC@85021|Intrasporangiaceae	201174|Actinobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS3_k127_4021471_5	1193181.BN10_580045	9.934e-172	558.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4FG3M@85021|Intrasporangiaceae	201174|Actinobacteria	CP	Proton-conducting membrane transporter	mnhD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
TLS3_k127_4021471_20	1193181.BN10_580044	3.066e-43	162.0	COG1863@1|root,COG1863@2|Bacteria,2GTN7@201174|Actinobacteria,4FHYV@85021|Intrasporangiaceae	201174|Actinobacteria	P	Na+/H+ ion antiporter subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS3_k127_4021471_25	1184607.AUCHE_16_01490	1.431e-13	74.0	COG2212@1|root,COG2212@2|Bacteria,2HT3P@201174|Actinobacteria,4F87C@85018|Dermatophilaceae	201174|Actinobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	-	-	-	-	-	-	-	-	-	MrpF_PhaF
TLS3_k127_4021471_22	1193181.BN10_580042	5.552e-37	143.0	COG1320@1|root,COG1320@2|Bacteria,2GS4N@201174|Actinobacteria,4FHPX@85021|Intrasporangiaceae	201174|Actinobacteria	P	Na+/H+ antiporter subunit	mnhG	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS3_k127_4021471_24	350058.Mvan_4725	5.472e-16	81.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,232HK@1762|Mycobacteriaceae	201174|Actinobacteria	V	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_4037475_2	367299.JOEE01000004_gene990	2.318e-173	550.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4FEY0@85021|Intrasporangiaceae	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS3_k127_4037475_8	1193181.BN10_1140018	3.694e-90	312.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4FE7F@85021|Intrasporangiaceae	201174|Actinobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
TLS3_k127_4037475_7	1385521.N803_02330	1.131e-90	308.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4FGBY@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the SUA5 family	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
TLS3_k127_4037475_1	1385520.N802_02390	1.528e-250	781.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4FEQF@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
TLS3_k127_4037475_3	1193181.BN10_1140013	2.22e-153	493.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4FEH4@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase family 4	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
TLS3_k127_4037475_11	1385519.N801_16690	3.473e-22	102.0	2EMHN@1|root,33F69@2|Bacteria,2GQIW@201174|Actinobacteria,4FHWA@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4037475_12	1385518.N798_16305	8.964e-21	94.0	COG5336@1|root,COG5336@2|Bacteria,2GSDV@201174|Actinobacteria,4FHUN@85021|Intrasporangiaceae	201174|Actinobacteria	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4037475_4	1385520.N802_02365	1.047e-131	425.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4FG1G@85021|Intrasporangiaceae	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
TLS3_k127_4037475_10	1385519.N801_16705	8.459e-29	116.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4FHQR@85021|Intrasporangiaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
TLS3_k127_4037475_9	1385519.N801_16710	1.25e-73	252.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4FGEP@85021|Intrasporangiaceae	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
TLS3_k127_4037475_6	1193181.BN10_1140008	2.202e-106	351.0	COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria,4FGII@85021|Intrasporangiaceae	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
TLS3_k127_4037475_0	1193181.BN10_1140007	1.95e-316	975.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4FFAR@85021|Intrasporangiaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
TLS3_k127_4037475_5	367299.JOEE01000004_gene1001	1.288e-123	400.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4FF8Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS3_k127_4203771_1	1193181.BN10_290004	9.978e-149	484.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FEMJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS3_k127_4203771_0	1193181.BN10_290005	3.453e-187	591.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4FEBS@85021|Intrasporangiaceae	201174|Actinobacteria	E	glycine cleavage system	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS3_k127_4203771_3	1121385.AQXW01000004_gene1346	1.16e-17	84.0	2EFWK@1|root,339NW@2|Bacteria,2IQXQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4203771_2	1385518.N798_08265	1.977e-38	147.0	2AN86@1|root,31D67@2|Bacteria,2HWWU@201174|Actinobacteria,4FG05@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3043)	-	GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	-	-	-	-	-	-	-	-	-	DUF3043
TLS3_k127_4220081_11	196162.Noca_4395	6.841e-10	62.0	29ZVZ@1|root,30MXA@2|Bacteria,2HBZR@201174|Actinobacteria,4DW1T@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4220081_7	1122622.ATWJ01000014_gene299	3.867e-52	192.0	COG0695@1|root,COG0695@2|Bacteria,2IIMP@201174|Actinobacteria,4FI20@85021|Intrasporangiaceae	201174|Actinobacteria	O	Glutaredoxin	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
TLS3_k127_4220081_8	1157943.KB892705_gene3259	4.833e-46	168.0	COG1403@1|root,COG1403@2|Bacteria,2IME8@201174|Actinobacteria,23A74@1762|Mycobacteriaceae	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
TLS3_k127_4220081_1	931627.MycrhDRAFT_0834	1.503e-126	410.0	COG3588@1|root,COG3588@2|Bacteria,2GN1A@201174|Actinobacteria,233KA@1762|Mycobacteriaceae	201174|Actinobacteria	G	Aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
TLS3_k127_4220081_6	1193181.BN10_560039	1.816e-55	216.0	28Z40@1|root,2ZKWF@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1707)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707
TLS3_k127_4220081_4	436229.JOEH01000030_gene4752	4.049e-87	304.0	COG1819@1|root,COG1819@2|Bacteria,2I97R@201174|Actinobacteria	201174|Actinobacteria	CG	transferase activity, transferring hexosyl groups	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
TLS3_k127_4220081_10	58123.JOFJ01000002_gene2408	2.592e-24	110.0	COG1846@1|root,COG1846@2|Bacteria,2ISIQ@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
TLS3_k127_4220081_0	1193181.BN10_930017	0.0	1142.0	COG1131@1|root,COG2936@1|root,COG1131@2|Bacteria,COG2936@2|Bacteria,2GN8P@201174|Actinobacteria,4FF6G@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,PepX_C,Peptidase_S15
TLS3_k127_4220081_2	1193181.BN10_930016	1.589e-105	368.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,4FFF2@85021|Intrasporangiaceae	201174|Actinobacteria	S	integral membrane protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
TLS3_k127_4220081_3	227882.SAV_2111	4.995e-101	339.0	COG2040@1|root,COG2040@2|Bacteria,2GIWK@201174|Actinobacteria	201174|Actinobacteria	E	Homocysteine	mmuM	-	2.1.1.10	ko:K00547,ko:K21169	ko00270,ko01059,ko01100,ko01110,ko01130,map00270,map01059,map01100,map01110,map01130	M00825	R00650	RC00003,RC00035	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
TLS3_k127_4220081_5	1120960.ATXG01000022_gene1300	9.328e-59	211.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS3_k127_4220903_5	1120959.ATXF01000010_gene185	0.0002771	51.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	201174|Actinobacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
TLS3_k127_4220903_3	1313421.JHBV01000010_gene4173	4.594e-48	184.0	2DBMF@1|root,2Z9YG@2|Bacteria,4NPRW@976|Bacteroidetes,1ISF6@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4220903_0	367299.JOEE01000006_gene813	3.912e-191	608.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4FFS6@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_4220903_4	457425.XNR_1710	6.915e-19	96.0	2EGCD@1|root,33A46@2|Bacteria,2GIVH@201174|Actinobacteria	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190,Septum_form
TLS3_k127_4220903_1	1386089.N865_04240	1.211e-121	395.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4FF7H@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
TLS3_k127_4220903_2	367299.JOEE01000006_gene808	6.514e-99	330.0	COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4FIQI@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_4223099_4	1206101.AZXC01000020_gene5239	1.539e-26	113.0	COG3861@1|root,COG3861@2|Bacteria,2IQDX@201174|Actinobacteria	201174|Actinobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4223099_3	367299.JOEE01000003_gene2814	1.254e-41	160.0	COG1514@1|root,COG1514@2|Bacteria,2GNDN@201174|Actinobacteria,4FG46@85021|Intrasporangiaceae	201174|Actinobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
TLS3_k127_4223099_0	1385518.N798_06640	1.208e-221	701.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,4FFE4@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
TLS3_k127_4223099_1	1385519.N801_17685	1.154e-202	645.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4FFJF@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
TLS3_k127_4223099_5	1285583.CCASEI_13560	6.149e-24	109.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,22K8T@1653|Corynebacteriaceae	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS3_k127_4223099_2	1172188.KB911824_gene3262	6.459e-118	382.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4FEAG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_4254029_3	1043205.AFYF01000090_gene1077	1.224e-185	589.0	COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria,4FEW3@85021|Intrasporangiaceae	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_4254029_8	1043205.AFYF01000090_gene1078	3.75e-115	380.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria,4FEWJ@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS3_k127_4254029_22	1385521.N803_05810	3.183e-49	179.0	2BX7X@1|root,32RMD@2|Bacteria,2IKN7@201174|Actinobacteria,4FJ5M@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4254029_24	1193181.BN10_300021	1.88e-35	143.0	2EP16@1|root,33GN1@2|Bacteria,2HXS6@201174|Actinobacteria,4FHN8@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4254029_2	1193181.BN10_300020	1.984e-186	589.0	COG4992@1|root,COG4992@2|Bacteria,2GK0J@201174|Actinobacteria,4FF57@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	rocD	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_4254029_16	1246995.AFR_32365	1.5e-64	231.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4DCP2@85008|Micromonosporales	201174|Actinobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS3_k127_4254029_12	367299.JOEE01000004_gene1333	1.133e-90	307.0	COG2267@1|root,COG2267@2|Bacteria,2GMY4@201174|Actinobacteria,4FG8J@85021|Intrasporangiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
TLS3_k127_4254029_13	1385519.N801_00375	1.396e-85	305.0	COG1216@1|root,COG1216@2|Bacteria,2GNXX@201174|Actinobacteria,4FFES@85021|Intrasporangiaceae	201174|Actinobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
TLS3_k127_4254029_15	1385518.N798_07250	3.403e-68	248.0	COG4671@1|root,COG4671@2|Bacteria,2HKUF@201174|Actinobacteria,4FFVP@85021|Intrasporangiaceae	201174|Actinobacteria	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
TLS3_k127_4254029_9	1043205.AFYF01000023_gene760	9.609e-115	392.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,4FFMJ@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_4254029_21	367299.JOEE01000002_gene2315	2.576e-52	194.0	COG1215@1|root,COG1215@2|Bacteria,2IHNF@201174|Actinobacteria,4FH6Z@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS3_k127_4254029_17	710696.Intca_0162	1.233e-63	226.0	COG3091@1|root,COG3091@2|Bacteria,2IJ4Z@201174|Actinobacteria,4FGNV@85021|Intrasporangiaceae	201174|Actinobacteria	S	SprT homologues.	-	-	-	-	-	-	-	-	-	-	-	-	SprT-like
TLS3_k127_4254029_14	1386089.N865_05110	2.885e-74	260.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria,4FHJZ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2,Polysacc_deac_1
TLS3_k127_4254029_26	110319.CF8_3749	4.91e-24	104.0	291UT@1|root,2ZPEM@2|Bacteria,2H9SK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4254029_5	35754.JNYJ01000040_gene1504	5.213e-169	545.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4D9FK@85008|Micromonosporales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_4254029_10	367299.JOEE01000002_gene2228	4.45e-102	336.0	COG1266@1|root,COG1266@2|Bacteria,2I925@201174|Actinobacteria,4FE7G@85021|Intrasporangiaceae	201174|Actinobacteria	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS3_k127_4254029_6	367299.JOEE01000002_gene2229	1.548e-157	503.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4FED9@85021|Intrasporangiaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
TLS3_k127_4254029_20	710685.MycrhN_5982	1.047e-56	211.0	2CA0C@1|root,30S8C@2|Bacteria,2IE01@201174|Actinobacteria,23B8K@1762|Mycobacteriaceae	201174|Actinobacteria	S	EcsC protein family	-	-	-	-	-	-	-	-	-	-	-	-	EcsC
TLS3_k127_4254029_7	1304865.JAGF01000001_gene703	1.347e-128	426.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	txlA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,SfLAP,Thioredoxin
TLS3_k127_4254029_1	1121017.AUFG01000013_gene1904	3.112e-232	728.0	COG3033@1|root,COG3033@2|Bacteria,2GKH3@201174|Actinobacteria,4FIW0@85021|Intrasporangiaceae	201174|Actinobacteria	E	Beta-eliminating lyase	tpl	-	4.1.99.1,4.1.99.2	ko:K01667,ko:K01668	ko00350,ko00380,map00350,map00380	-	R00673,R00728	RC00209,RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS3_k127_4254029_23	1283283.ATXA01000005_gene2101	8.423e-36	143.0	2CQ6K@1|root,32SKJ@2|Bacteria,2INNI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4254029_0	263358.VAB18032_22385	0.0	1047.0	COG2866@1|root,COG2866@2|Bacteria,2IAU2@201174|Actinobacteria,4DHB0@85008|Micromonosporales	201174|Actinobacteria	M	Carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Peptidase_M14
TLS3_k127_4254029_19	1385520.N802_06825	2.094e-59	222.0	29YV4@1|root,30KRI@2|Bacteria,2GZNX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4254029_4	1122622.ATWJ01000014_gene414	3.451e-174	554.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4FFJK@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS3_k127_4254029_11	1122933.JNIY01000003_gene251	3.02e-93	315.0	COG0702@1|root,COG0702@2|Bacteria,2GKXI@201174|Actinobacteria,4F2I0@85016|Cellulomonadaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA,SnoaL_2
TLS3_k127_4254029_27	222534.KB893725_gene277	2.054e-09	65.0	COG1846@1|root,COG1846@2|Bacteria,2HGXY@201174|Actinobacteria,4ETAI@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_4254029_18	1122933.JNIY01000003_gene250	2.127e-63	224.0	COG0702@1|root,COG0702@2|Bacteria,2I234@201174|Actinobacteria,4F30R@85016|Cellulomonadaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS3_k127_4254029_25	1197706.AKKK01000064_gene4223	2.387e-24	105.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,1WAIH@1268|Micrococcaceae	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_425820_3	479431.Namu_1835	4.181e-20	100.0	COG0845@1|root,COG0845@2|Bacteria,2IPE7@201174|Actinobacteria	201174|Actinobacteria	M	PFAM biotin lipoyl attachment domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
TLS3_k127_425820_1	446466.Cfla_3152	1.38e-118	413.0	COG5498@1|root,COG5498@2|Bacteria,2GNW3@201174|Actinobacteria	201174|Actinobacteria	M	glycoside hydrolase family 81	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_81
TLS3_k127_425820_0	1385521.N803_12245	3.565e-240	758.0	COG0296@1|root,COG0296@2|Bacteria,2IA2H@201174|Actinobacteria,4FEKD@85021|Intrasporangiaceae	201174|Actinobacteria	G	1,4-alpha-glucan branching enzyme	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS3_k127_425820_2	367299.JOEE01000002_gene2529	2.156e-65	234.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4FEQJ@85021|Intrasporangiaceae	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS3_k127_4312980_0	313589.JNB_13668	4.735e-293	904.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4FES5@85021|Intrasporangiaceae	201174|Actinobacteria	O	ATP-dependent Clp protease	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS3_k127_4312980_7	1157635.KB892046_gene5566	4.582e-44	185.0	COG2304@1|root,COG2304@2|Bacteria,2GUB3@201174|Actinobacteria	201174|Actinobacteria	P	von willebrand factor type a	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,VWA
TLS3_k127_4312980_6	1121946.AUAX01000026_gene6308	7.031e-89	308.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4D9ZP@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
TLS3_k127_4312980_5	1193181.BN10_1020003	8.648e-121	413.0	COG0266@1|root,COG0266@2|Bacteria,2GKUI@201174|Actinobacteria,4FG79@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the FPG family	nei1	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K05522,ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS3_k127_4312980_1	1298863.AUEP01000013_gene4093	3.514e-188	599.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria,4DT97@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
TLS3_k127_4312980_2	1385518.N798_12985	4.512e-138	449.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4FEKJ@85021|Intrasporangiaceae	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
TLS3_k127_4312980_4	1385519.N801_07090	1.419e-127	416.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,4FEWY@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
TLS3_k127_4312980_3	1385519.N801_07095	3.59e-133	436.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4FF44@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA ligase	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
TLS3_k127_4337912_29	1385518.N798_11105	1.283e-27	121.0	COG0500@1|root,COG2226@2|Bacteria,2HXA9@201174|Actinobacteria,4FG1I@85021|Intrasporangiaceae	201174|Actinobacteria	H	Ubiquinone biosynthesis O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_4337912_22	313589.JNB_18693	1.059e-89	306.0	COG0392@1|root,COG0392@2|Bacteria,2IC25@201174|Actinobacteria,4FE40@85021|Intrasporangiaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	Glycos_transf_2,LPG_synthase_TM
TLS3_k127_4337912_2	367299.JOEE01000003_gene2986	1.657e-197	635.0	COG0438@1|root,COG0438@2|Bacteria,2GX8V@201174|Actinobacteria,4FE76@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_4337912_10	367299.JOEE01000003_gene2987	8.59e-147	477.0	COG0463@1|root,COG0463@2|Bacteria,2HX64@201174|Actinobacteria,4FF0R@85021|Intrasporangiaceae	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_4337912_4	1385518.N798_11190	3.855e-176	574.0	COG1287@1|root,COG1287@2|Bacteria,2IF8Q@201174|Actinobacteria,4FGAK@85021|Intrasporangiaceae	201174|Actinobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
TLS3_k127_4337912_9	1385520.N802_18705	2.481e-155	512.0	COG3409@1|root,COG3409@2|Bacteria,2IDIJ@201174|Actinobacteria,4FF8V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
TLS3_k127_4337912_17	1385518.N798_11205	1.795e-120	398.0	COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria,4FFDC@85021|Intrasporangiaceae	201174|Actinobacteria	I	COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS3_k127_4337912_18	313589.JNB_18603	2.556e-108	353.0	COG2057@1|root,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria,4FFD8@85021|Intrasporangiaceae	201174|Actinobacteria	I	Succinyl-CoA 3-ketoacid-CoA transferase	scoB	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
TLS3_k127_4337912_30	479433.Caci_5764	1.087e-17	98.0	COG0823@1|root,COG0823@2|Bacteria,2IDJU@201174|Actinobacteria	201174|Actinobacteria	U	Putative cell wall binding repeat 2	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CW_binding_2,PD40
TLS3_k127_4337912_23	1210046.B277_13689	1.968e-81	298.0	COG2385@1|root,COG2385@2|Bacteria,2IEPH@201174|Actinobacteria	201174|Actinobacteria	D	SpoIID LytB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LGFP,SpoIID
TLS3_k127_4337912_7	1184609.KILIM_067_00290	2.521e-161	516.0	COG0381@1|root,COG0381@2|Bacteria,2GJWS@201174|Actinobacteria,4F7JK@85018|Dermatophilaceae	201174|Actinobacteria	M	UDP-N-acetylglucosamine 2-epimerase	mnaA	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS3_k127_4337912_27	1120950.KB892739_gene3923	5.598e-68	258.0	COG5017@1|root,COG5017@2|Bacteria,2IPEE@201174|Actinobacteria,4DVN0@85009|Propionibacteriales	201174|Actinobacteria	S	D-glucuronyl C5-epimerase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	C5-epim_C
TLS3_k127_4337912_21	1134445.AJJM01000228_gene1856	4.014e-94	325.0	COG0438@1|root,COG0438@2|Bacteria,2H21W@201174|Actinobacteria	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
TLS3_k127_4337912_24	479433.Caci_7643	1.754e-74	273.0	COG0438@1|root,COG2414@1|root,COG0438@2|Bacteria,COG2414@2|Bacteria,2I3KI@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
TLS3_k127_4337912_25	1449353.JQMQ01000005_gene3796	2.327e-73	268.0	COG0438@1|root,COG0438@2|Bacteria,2GNR8@201174|Actinobacteria,2NG1R@228398|Streptacidiphilus	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	ko:K19424	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_4337912_1	1184609.KILIM_067_00320	7.284e-204	649.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,4F660@85018|Dermatophilaceae	201174|Actinobacteria	M	UDP binding domain	wecC	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
TLS3_k127_4337912_13	1238186.AOCN01000019_gene384	7.003e-135	439.0	COG0381@1|root,COG0381@2|Bacteria,2GJWS@201174|Actinobacteria,4FP4J@85023|Microbacteriaceae	201174|Actinobacteria	M	UDP-N-acetylglucosamine 2-epimerase	mnaA	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
TLS3_k127_4337912_26	1089455.MOPEL_003_01010	9.253e-73	269.0	COG0438@1|root,COG0438@2|Bacteria,2I3KI@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
TLS3_k127_4337912_5	313589.JNB_18553	7.361e-168	550.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4FG4S@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_4337912_0	313589.JNB_18548	2.376e-207	648.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4FF60@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
TLS3_k127_4337912_19	313589.JNB_18543	5.938e-107	349.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,4FEN5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	wbpD	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
TLS3_k127_4337912_6	1089455.MOPEL_003_00990	1.744e-166	536.0	COG0438@1|root,COG0438@2|Bacteria,2H21W@201174|Actinobacteria,4F7H0@85018|Dermatophilaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
TLS3_k127_4337912_20	313589.JNB_18523	4.917e-96	338.0	COG0438@1|root,COG0438@2|Bacteria,2GNUU@201174|Actinobacteria,4FIFI@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_4337912_14	313589.JNB_18518	1.336e-127	420.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4FGNF@85021|Intrasporangiaceae	201174|Actinobacteria	GM	ABC transporter	-	-	3.6.3.40	ko:K09693	ko02010,map02010	M00251	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.104	-	-	ABC_tran
TLS3_k127_4337912_16	1385520.N802_18775	4.543e-124	403.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4FHVK@85021|Intrasporangiaceae	201174|Actinobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09692	ko02010,map02010	M00251	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.104	-	-	ABC2_membrane
TLS3_k127_4337912_12	313589.JNB_18508	4.224e-140	464.0	COG0438@1|root,COG0438@2|Bacteria,2I9XX@201174|Actinobacteria,4FIPP@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
TLS3_k127_4337912_11	1172188.KB911824_gene3171	9.269e-141	460.0	COG1215@1|root,COG1215@2|Bacteria,2GMWF@201174|Actinobacteria,4FEM8@85021|Intrasporangiaceae	201174|Actinobacteria	M	glycosyl transferase family 2	exoA	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
TLS3_k127_4337912_8	367299.JOEE01000003_gene3009	1.362e-157	515.0	COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4FEYR@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS3_k127_4337912_15	367299.JOEE01000003_gene3010	2.258e-126	420.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4FEU8@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	lytR2	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS3_k127_4337912_28	1122622.ATWJ01000001_gene2567	1.533e-54	196.0	2B4YW@1|root,31XRX@2|Bacteria,2GXA5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4337912_3	367299.JOEE01000003_gene3020	1.402e-180	567.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FFGR@85021|Intrasporangiaceae	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_435518_2	1048339.KB913029_gene2950	1.311e-87	291.0	COG2514@1|root,COG2514@2|Bacteria,2I4TW@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_435518_0	1385519.N801_00645	3.411e-164	533.0	COG0400@1|root,COG0400@2|Bacteria,2I5NR@201174|Actinobacteria,4FG0T@85021|Intrasporangiaceae	201174|Actinobacteria	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
TLS3_k127_435518_1	290399.Arth_3613	1.643e-148	481.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria	201174|Actinobacteria	P	membrane protein terC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
TLS3_k127_435518_3	1121271.AUCM01000003_gene1318	1.045e-29	121.0	2CSMT@1|root,32SRG@2|Bacteria,1N0NU@1224|Proteobacteria,2UBXU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
TLS3_k127_435518_4	1304865.JAGF01000001_gene965	1.312e-29	120.0	2EG8Z@1|root,33A0S@2|Bacteria,2I8BH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4380959_4	1385518.N798_14240	1.152e-89	317.0	COG2304@1|root,COG2304@2|Bacteria,2GUB3@201174|Actinobacteria,4FFUP@85021|Intrasporangiaceae	201174|Actinobacteria	P	Von Willebrand factor	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,VWA
TLS3_k127_4380959_0	1121017.AUFG01000002_gene2741	5.661e-253	792.0	COG1012@1|root,COG1012@2|Bacteria,2GNJJ@201174|Actinobacteria,4FES3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
TLS3_k127_4380959_6	1121017.AUFG01000002_gene2728	2.273e-43	177.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria,4FHD0@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
TLS3_k127_4380959_3	710696.Intca_0247	3.137e-159	510.0	COG0079@1|root,COG0079@2|Bacteria,2GJXS@201174|Actinobacteria,4FEZ6@85021|Intrasporangiaceae	201174|Actinobacteria	E	May catalyze the transamination reaction in phenylalanine biosynthesis	pat	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
TLS3_k127_4380959_7	1089549.AZUQ01000001_gene378	0.0002769	49.0	2EJTC@1|root,33DHZ@2|Bacteria,2HUMF@201174|Actinobacteria,4EZ41@85014|Glycomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4380959_1	367299.JOEE01000002_gene2391	7.187e-194	612.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4FF0X@85021|Intrasporangiaceae	201174|Actinobacteria	C	Pyruvate dehydrogenase E1	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
TLS3_k127_4380959_2	367299.JOEE01000002_gene2390	5.035e-163	529.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4FF51@85021|Intrasporangiaceae	201174|Actinobacteria	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
TLS3_k127_4380959_5	367299.JOEE01000002_gene2389	3.469e-50	185.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4FFEF@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_4402958_2	103733.JNYO01000023_gene7178	2.381e-207	653.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4DXCE@85010|Pseudonocardiales	201174|Actinobacteria	G	Alpha amylase, catalytic domain	nplT	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459
TLS3_k127_4402958_10	710696.Intca_3501	1.162e-36	140.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4FJ7R@85021|Intrasporangiaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
TLS3_k127_4402958_9	710696.Intca_3502	4.888e-41	154.0	COG2161@1|root,COG2161@2|Bacteria,2GRC8@201174|Actinobacteria,4FJ8S@85021|Intrasporangiaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
TLS3_k127_4402958_7	1121019.AUMN01000003_gene1021	5.895e-59	207.0	COG1487@1|root,COG1487@2|Bacteria,2IS29@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
TLS3_k127_4402958_12	1108045.GORHZ_171_00530	1.737e-28	121.0	COG4691@1|root,COG4691@2|Bacteria,2GSHN@201174|Actinobacteria	201174|Actinobacteria	S	Plasmid stability protein	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	Arc
TLS3_k127_4402958_0	1122622.ATWJ01000010_gene1258	6.084e-312	967.0	COG0477@1|root,COG2814@2|Bacteria,2H8UD@201174|Actinobacteria,4FFQ3@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1
TLS3_k127_4402958_6	1122622.ATWJ01000010_gene1257	1.706e-61	223.0	COG1309@1|root,COG1309@2|Bacteria,2HQ2V@201174|Actinobacteria,4FJEB@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_4402958_11	1463917.JODC01000009_gene8867	7.783e-35	149.0	COG0628@1|root,COG0628@2|Bacteria,2GU1U@201174|Actinobacteria	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_4402958_1	1193181.BN10_230020	1.416e-288	893.0	COG0365@1|root,COG0365@2|Bacteria,2GJSQ@201174|Actinobacteria,4FEKR@85021|Intrasporangiaceae	201174|Actinobacteria	I	AMP-dependent synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_4402958_3	1380370.JIBA01000015_gene260	1.796e-157	511.0	COG0433@1|root,COG0433@2|Bacteria,2HUQ6@201174|Actinobacteria,4FF14@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
TLS3_k127_4402958_8	367299.JOEE01000006_gene862	9.195e-52	194.0	COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria,4FH6S@85021|Intrasporangiaceae	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,NLPC_P60
TLS3_k127_4402958_13	367299.JOEE01000006_gene861	4.507e-26	124.0	COG3103@1|root,COG3103@2|Bacteria,2I3RJ@201174|Actinobacteria,4FJZT@85021|Intrasporangiaceae	201174|Actinobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
TLS3_k127_4402958_4	1385518.N798_14145	1.316e-108	355.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria,4FFDP@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
TLS3_k127_4402958_5	1121017.AUFG01000007_gene1207	2.65e-85	301.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4FEJD@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
TLS3_k127_4412704_10	1108045.GORHZ_038_00240	6.142e-60	229.0	COG3057@1|root,COG3057@2|Bacteria,2I60V@201174|Actinobacteria	201174|Actinobacteria	L	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4412704_9	1184609.KILIM_013_00130	1.4e-108	363.0	COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
TLS3_k127_4412704_4	743718.Isova_2761	1.536e-157	524.0	COG3391@1|root,COG3391@2|Bacteria,2GP11@201174|Actinobacteria,4F52S@85017|Promicromonosporaceae	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS3_k127_4412704_2	1122622.ATWJ01000002_gene813	6.72e-219	691.0	COG4630@1|root,COG4630@2|Bacteria,2I33J@201174|Actinobacteria,4FF1M@85021|Intrasporangiaceae	201174|Actinobacteria	F	CO dehydrogenase flavoprotein C-terminal domain	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
TLS3_k127_4412704_0	1385519.N801_13810	0.0	1247.0	COG4631@1|root,COG4631@2|Bacteria,2I33I@201174|Actinobacteria,4FE7A@85021|Intrasporangiaceae	201174|Actinobacteria	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	xdhB	-	1.17.1.4	ko:K13482	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_4412704_7	1122622.ATWJ01000002_gene815	5.874e-117	382.0	COG1975@1|root,COG1975@2|Bacteria,2HX70@201174|Actinobacteria,4FFBZ@85021|Intrasporangiaceae	201174|Actinobacteria	O	xanthine dehydrogenase accessory protein XdhC	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
TLS3_k127_4412704_6	1380370.JIBA01000015_gene254	3.702e-119	395.0	COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria,4FETZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Aldo/keto reductase family	dkgB	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_4412704_8	1122622.ATWJ01000012_gene1062	1.77e-116	382.0	COG3741@1|root,COG3741@2|Bacteria,2IEZX@201174|Actinobacteria,4FIQZ@85021|Intrasporangiaceae	201174|Actinobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
TLS3_k127_4412704_5	110319.CF8_0171	3.813e-135	445.0	COG3930@1|root,COG3930@2|Bacteria,2IATJ@201174|Actinobacteria,4DT1A@85009|Propionibacteriales	201174|Actinobacteria	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
TLS3_k127_4412704_3	1385518.N798_05110	1.673e-166	536.0	COG0189@1|root,COG0189@2|Bacteria,2IDUN@201174|Actinobacteria,4FFU2@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
TLS3_k127_4412704_1	1385518.N798_11705	1.88e-273	882.0	COG2319@1|root,COG3391@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3391@2|Bacteria,COG3629@2|Bacteria,2GJN3@201174|Actinobacteria,4FE3I@85021|Intrasporangiaceae	201174|Actinobacteria	K	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,PD40,Trans_reg_C,WD40
TLS3_k127_4437378_2	710696.Intca_3196	2.24e-116	389.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4FG1Q@85021|Intrasporangiaceae	201174|Actinobacteria	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
TLS3_k127_4437378_5	1121385.AQXW01000004_gene1492	2.897e-52	195.0	COG0346@1|root,COG0346@2|Bacteria,2I19A@201174|Actinobacteria,1ZW94@145357|Dermacoccaceae	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4437378_1	313589.JNB_17313	3.167e-164	527.0	COG0849@1|root,COG0849@2|Bacteria,2GK4G@201174|Actinobacteria,4FFED@85021|Intrasporangiaceae	201174|Actinobacteria	D	Glutamate mutase	mutL	-	-	-	-	-	-	-	-	-	-	-	MutL
TLS3_k127_4437378_0	367299.JOEE01000007_gene155	8.29e-210	676.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4FE6W@85021|Intrasporangiaceae	201174|Actinobacteria	E	cystathionine gamma-synthase	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
TLS3_k127_4437378_4	367299.JOEE01000007_gene156	6.117e-94	330.0	COG0454@1|root,COG0456@2|Bacteria,2I8J8@201174|Actinobacteria,4FGFD@85021|Intrasporangiaceae	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_4437378_3	313589.JNB_17278	5.266e-109	374.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4FEC2@85021|Intrasporangiaceae	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
TLS3_k127_4437378_6	1385521.N803_13425	1.411e-14	78.0	2BPP9@1|root,32IGG@2|Bacteria,2H70T@201174|Actinobacteria,4FJB1@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4440851_9	227882.SAV_4994	7.512e-08	55.0	COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_4440851_4	313589.JNB_15543	3.228e-91	302.0	COG0461@1|root,COG0461@2|Bacteria,2GKUQ@201174|Actinobacteria,4FENS@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
TLS3_k127_4440851_1	367299.JOEE01000001_gene1735	2.031e-204	657.0	COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria,4FE35@85021|Intrasporangiaceae	201174|Actinobacteria	E	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
TLS3_k127_4440851_7	367299.JOEE01000001_gene1736	6.281e-51	184.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_4440851_5	1193181.BN10_800004	1.343e-89	302.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4FG24@85021|Intrasporangiaceae	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
TLS3_k127_4440851_3	110319.CF8_3707	1.863e-138	447.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4DTDD@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_4440851_0	1385519.N801_10330	6.318e-263	819.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4FEJ1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
TLS3_k127_4440851_2	1298863.AUEP01000002_gene1408	9.992e-160	510.0	COG0389@1|root,COG0389@2|Bacteria,2GKHC@201174|Actinobacteria,4DNMF@85009|Propionibacteriales	201174|Actinobacteria	L	impB/mucB/samB family C-terminal domain	dinP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
TLS3_k127_4440851_6	367299.JOEE01000001_gene1738	9.965e-66	229.0	COG0640@1|root,COG0640@2|Bacteria,2IKVA@201174|Actinobacteria,4FGIZ@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_4440851_8	313589.JNB_15568	1.335e-50	190.0	COG0477@1|root,COG2814@2|Bacteria,2IA1T@201174|Actinobacteria,4FG6X@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_4534137_12	1386089.N865_20875	4.542e-51	183.0	COG0346@1|root,COG0346@2|Bacteria,2HY1F@201174|Actinobacteria,4FJAT@85021|Intrasporangiaceae	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4534137_1	1121385.AQXW01000003_gene592	1.265e-185	608.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria	201174|Actinobacteria	S	unusual protein kinase	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
TLS3_k127_4534137_8	714961.BFZC1_10462	4.075e-79	275.0	COG0596@1|root,COG0596@2|Bacteria,1V202@1239|Firmicutes,4HJ0U@91061|Bacilli,3IXMV@400634|Lysinibacillus	91061|Bacilli	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_4534137_11	35754.JNYJ01000002_gene6950	1.871e-55	196.0	COG2764@1|root,COG2764@2|Bacteria,2IN3F@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
TLS3_k127_4534137_2	1122622.ATWJ01000011_gene2132	2.226e-126	411.0	COG2116@1|root,COG2116@2|Bacteria,2GNU6@201174|Actinobacteria,4FGKP@85021|Intrasporangiaceae	201174|Actinobacteria	P	Formate/nitrite transporter	focA	-	-	-	-	-	-	-	-	-	-	-	Form_Nir_trans
TLS3_k127_4534137_3	1120954.ATXE01000004_gene21	1.785e-125	419.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,2GJB4@201174|Actinobacteria,4DP6X@85009|Propionibacteriales	201174|Actinobacteria	CE	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
TLS3_k127_4534137_5	543632.JOJL01000010_gene7218	1.25e-121	401.0	arCOG05230@1|root,33GXI@2|Bacteria,2ICB0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4534137_4	367299.JOEE01000008_gene501	3.763e-123	406.0	COG0147@1|root,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4FE4W@85021|Intrasporangiaceae	201174|Actinobacteria	EH	Chloride transporter	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
TLS3_k127_4534137_6	367299.JOEE01000008_gene502	4.331e-107	369.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria,4FE9F@85021|Intrasporangiaceae	201174|Actinobacteria	EH	Class IV aminotransferase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS3_k127_4534137_14	313589.JNB_02300	3.634e-33	137.0	2E4Q9@1|root,32ZIV@2|Bacteria,2II59@201174|Actinobacteria,4FHDW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative transmembrane protein (PGPGW)	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
TLS3_k127_4534137_15	1273125.Rrhod_4080	1.95e-15	84.0	291PE@1|root,2ZP9J@2|Bacteria,2H9WW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4534137_0	1386089.N865_18550	0.0	1490.0	COG4581@1|root,COG4581@2|Bacteria,2GJSV@201174|Actinobacteria,4FEIY@85021|Intrasporangiaceae	201174|Actinobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF3516,Helicase_C
TLS3_k127_4534137_10	1386089.N865_17555	1.971e-57	229.0	COG3449@1|root,COG3449@2|Bacteria,2IHU0@201174|Actinobacteria,4FJ2R@85021|Intrasporangiaceae	201174|Actinobacteria	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
TLS3_k127_4534137_9	1385519.N801_12755	1.54e-73	259.0	COG0702@1|root,COG0702@2|Bacteria,2ICEY@201174|Actinobacteria,4FHR4@85021|Intrasporangiaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
TLS3_k127_4534137_7	1206744.BAGL01000055_gene1471	6.177e-96	333.0	COG0655@1|root,COG0655@2|Bacteria,2GKTM@201174|Actinobacteria,4FTXE@85025|Nocardiaceae	201174|Actinobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS3_k127_4534137_13	1385521.N803_15175	1.979e-44	170.0	COG3945@1|root,COG3945@2|Bacteria,2INA1@201174|Actinobacteria,4FJ37@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS3_k127_4583046_29	710696.Intca_2547	1.207e-15	88.0	COG0476@1|root,COG0476@2|Bacteria,2HXET@201174|Actinobacteria,4FGE8@85021|Intrasporangiaceae	201174|Actinobacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4583046_7	1385521.N803_02655	6.529e-198	630.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4FET1@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
TLS3_k127_4583046_20	1121385.AQXW01000004_gene1193	1.581e-84	286.0	COG0122@1|root,COG0122@2|Bacteria,2I3NS@201174|Actinobacteria	201174|Actinobacteria	L	HhH-GPD superfamily base excision DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
TLS3_k127_4583046_25	1121017.AUFG01000003_gene3453	4.639e-36	147.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria,4FHIQ@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	-	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
TLS3_k127_4583046_4	1385521.N803_02695	9.935e-259	817.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4FFFK@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
TLS3_k127_4583046_27	367299.JOEE01000014_gene915	1.044e-26	113.0	COG0695@1|root,COG0695@2|Bacteria,2IQF9@201174|Actinobacteria,4FHU0@85021|Intrasporangiaceae	201174|Actinobacteria	O	Glutaredoxin	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
TLS3_k127_4583046_19	710696.Intca_2555	5.036e-89	303.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria,4FFWB@85021|Intrasporangiaceae	201174|Actinobacteria	L	Nudix hydrolase	nudC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
TLS3_k127_4583046_16	367299.JOEE01000014_gene913	5.006e-97	353.0	COG3173@1|root,COG3173@2|Bacteria,2I8R6@201174|Actinobacteria,4FE3M@85021|Intrasporangiaceae	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	mphA	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_4583046_0	1385518.N798_08795	1.486e-308	983.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4FE4M@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
TLS3_k127_4583046_8	1115632.JAFW01000001_gene800	1.465e-187	625.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,1W8FJ@1268|Micrococcaceae	201174|Actinobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C
TLS3_k127_4583046_14	1121017.AUFG01000003_gene3445	9.868e-117	390.0	COG0476@1|root,COG0476@2|Bacteria,2GJB6@201174|Actinobacteria,4FF9A@85021|Intrasporangiaceae	201174|Actinobacteria	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are	moeB	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
TLS3_k127_4583046_21	367299.JOEE01000012_gene3276	5.021e-75	259.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria,4FFZW@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_4583046_28	1385520.N802_02770	9.303e-22	98.0	2E3M2@1|root,32YJA@2|Bacteria,2HXUV@201174|Actinobacteria,4FHSG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
TLS3_k127_4583046_26	1385521.N803_02740	1.764e-30	126.0	COG2261@1|root,COG2261@2|Bacteria,2HXWE@201174|Actinobacteria,4FI3C@85021|Intrasporangiaceae	201174|Actinobacteria	S	transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS3_k127_4583046_23	367299.JOEE01000012_gene3273	3.194e-53	200.0	COG3396@1|root,COG3396@2|Bacteria,2GKXZ@201174|Actinobacteria,4FFQB@85021|Intrasporangiaceae	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
TLS3_k127_4583046_5	367299.JOEE01000012_gene3272	2.571e-228	719.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4FE9C@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
TLS3_k127_4583046_11	43354.JOIJ01000024_gene605	2.717e-140	458.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4E112@85010|Pseudonocardiales	201174|Actinobacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_4583046_13	1385519.N801_16480	2.64e-117	397.0	COG1192@1|root,COG1192@2|Bacteria,2GNEQ@201174|Actinobacteria,4FEP8@85021|Intrasporangiaceae	201174|Actinobacteria	D	Plasmid partitioning protein ParA	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
TLS3_k127_4583046_18	367299.JOEE01000012_gene3269	5.024e-95	322.0	COG0583@1|root,COG0583@2|Bacteria,2GTX3@201174|Actinobacteria,4FGH9@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K09681	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
TLS3_k127_4583046_30	367299.JOEE01000012_gene3243	2.391e-11	73.0	2BFEQ@1|root,2ZCZB@2|Bacteria,2GVJK@201174|Actinobacteria,4FHTJ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4583046_12	367299.JOEE01000012_gene3240	7.497e-137	442.0	COG0788@1|root,COG0788@2|Bacteria,2GM0G@201174|Actinobacteria,4FEJZ@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
TLS3_k127_4583046_15	1385518.N798_11455	1.825e-102	340.0	COG0613@1|root,COG0613@2|Bacteria,2GNAP@201174|Actinobacteria,4FF9Y@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metal-dependent phosphoesterase	PPA1328	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
TLS3_k127_4583046_9	1193181.BN10_1070014	4.488e-186	586.0	COG2030@1|root,COG2030@2|Bacteria,2GKFH@201174|Actinobacteria,4FFEA@85021|Intrasporangiaceae	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	4.2.1.148	ko:K14449	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R05076	RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
TLS3_k127_4583046_1	1385518.N798_11505	3.661e-280	866.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4FEUC@85021|Intrasporangiaceae	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
TLS3_k127_4583046_2	313589.JNB_07554	7.15e-273	853.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4FEIW@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
TLS3_k127_4583046_24	590998.Celf_1416	5.405e-49	188.0	2F2DM@1|root,33VBA@2|Bacteria,2HHW0@201174|Actinobacteria,4F1YI@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
TLS3_k127_4583046_3	1193181.BN10_1070024	2.568e-266	826.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4FFTK@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
TLS3_k127_4583046_17	1385519.N801_19615	2.487e-95	320.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4FGF3@85021|Intrasporangiaceae	201174|Actinobacteria	S	LmbE family	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
TLS3_k127_4583046_22	1193181.BN10_1070025	5.563e-69	239.0	2CAW2@1|root,32RS7@2|Bacteria,2IB15@201174|Actinobacteria,4FGBA@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4583046_6	1385520.N802_13040	2.7e-199	640.0	COG0726@1|root,COG2247@1|root,COG0726@2|Bacteria,COG2247@2|Bacteria,2HX9Q@201174|Actinobacteria,4FFZ3@85021|Intrasporangiaceae	201174|Actinobacteria	GM	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Polysacc_deac_1
TLS3_k127_4583046_10	1193181.BN10_1070026	1.117e-146	466.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4FED0@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_4618528_2	1380370.JIBA01000011_gene3318	1.274e-178	573.0	COG3173@1|root,COG3173@2|Bacteria,2GZAV@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_4618528_0	1385518.N798_05395	9.334e-307	961.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4FEA6@85021|Intrasporangiaceae	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
TLS3_k127_4618528_5	365528.KB891192_gene3603	3.517e-99	331.0	COG0300@1|root,COG0300@2|Bacteria,2GK2K@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_4618528_3	1449048.JQKU01000006_gene5177	1.117e-110	362.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria,23582@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_4618528_4	269800.Tfu_2810	2.278e-103	348.0	COG0614@1|root,COG0614@2|Bacteria,2GYJE@201174|Actinobacteria,4EHMG@85012|Streptosporangiales	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
TLS3_k127_4618528_7	1193181.BN10_470020	1.332e-53	194.0	COG0346@1|root,COG0346@2|Bacteria,2IHU2@201174|Actinobacteria,4FH8G@85021|Intrasporangiaceae	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4618528_9	1210046.B277_12746	1.252e-26	115.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	fcbC	-	-	ko:K07107,ko:K12500	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	4HBT,4HBT_2,Acyl-ACP_TE
TLS3_k127_4618528_6	367299.JOEE01000001_gene2126	4.472e-56	199.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,4FGJX@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
TLS3_k127_4618528_1	1380370.JIBA01000017_gene2918	4.944e-200	639.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4FEK1@85021|Intrasporangiaceae	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
TLS3_k127_4618528_10	1121385.AQXW01000004_gene2075	5.044e-09	58.0	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria,1ZW5H@145357|Dermacoccaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
TLS3_k127_4710093_17	1370120.AUWR01000021_gene2736	9.739e-43	157.0	COG0039@1|root,COG0039@2|Bacteria,2GJHS@201174|Actinobacteria,2349F@1762|Mycobacteriaceae	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS3_k127_4710093_1	367299.JOEE01000007_gene24	0.0	1155.0	COG2838@1|root,COG2838@2|Bacteria,2GJ1C@201174|Actinobacteria,4FFA1@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
TLS3_k127_4710093_20	1193181.BN10_520085	2.731e-13	76.0	2BSB2@1|root,32MCT@2|Bacteria,2HD7K@201174|Actinobacteria,4FJQU@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3017
TLS3_k127_4710093_8	367299.JOEE01000007_gene28	2.384e-150	479.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4FFH9@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
TLS3_k127_4710093_5	743718.Isova_2474	8.926e-179	573.0	COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria,4F49D@85017|Promicromonosporaceae	201174|Actinobacteria	L	ATP dependent DNA ligase domain	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
TLS3_k127_4710093_15	935866.JAER01000038_gene4164	1.2e-53	198.0	COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria,4DR04@85009|Propionibacteriales	201174|Actinobacteria	S	MobA-like NTP transferase domain	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
TLS3_k127_4710093_2	367299.JOEE01000007_gene30	2.094e-249	782.0	COG0074@1|root,COG0074@2|Bacteria,2GMFI@201174|Actinobacteria,4FF3V@85021|Intrasporangiaceae	201174|Actinobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,DUF1116,Ligase_CoA
TLS3_k127_4710093_4	367299.JOEE01000007_gene31	3.246e-204	657.0	COG0074@1|root,COG0074@2|Bacteria,2GN20@201174|Actinobacteria,4FE7B@85021|Intrasporangiaceae	201174|Actinobacteria	C	FdrA family	-	-	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,Ligase_CoA
TLS3_k127_4710093_19	367299.JOEE01000007_gene32	2.16e-25	116.0	2EIHP@1|root,33C91@2|Bacteria,2ICMY@201174|Actinobacteria,4FJY4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2877)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2877
TLS3_k127_4710093_7	1386089.N865_03205	2.265e-169	547.0	COG2508@1|root,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria,4FF6J@85021|Intrasporangiaceae	201174|Actinobacteria	QT	transcriptional regulator	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR
TLS3_k127_4710093_3	1193181.BN10_1110003	9.994e-245	767.0	COG2233@1|root,COG2233@2|Bacteria,2GMH6@201174|Actinobacteria,4FEI2@85021|Intrasporangiaceae	201174|Actinobacteria	F	Nitrate reductase	rutG	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
TLS3_k127_4710093_12	1385518.N798_05160	6.478e-104	351.0	COG1319@1|root,COG1319@2|Bacteria,2GP37@201174|Actinobacteria,4FFH6@85021|Intrasporangiaceae	201174|Actinobacteria	C	carbon monoxide dehydrogenase	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS3_k127_4710093_13	1380370.JIBA01000016_gene727	5.845e-80	274.0	COG2080@1|root,COG2080@2|Bacteria,2GMYH@201174|Actinobacteria,4FJVW@85021|Intrasporangiaceae	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS3_k127_4710093_0	1385521.N803_05490	0.0	1406.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FETX@85021|Intrasporangiaceae	201174|Actinobacteria	C	Xanthine dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_4710093_14	1172188.KB911825_gene3602	1.501e-64	235.0	COG3427@1|root,COG3427@2|Bacteria,2IEYK@201174|Actinobacteria,4FG7C@85021|Intrasporangiaceae	201174|Actinobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
TLS3_k127_4710093_9	1386089.N865_03240	6.421e-145	477.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria,4FEV1@85021|Intrasporangiaceae	201174|Actinobacteria	S	apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
TLS3_k127_4710093_16	710696.Intca_1079	1.22e-47	183.0	COG4902@1|root,COG4902@2|Bacteria,2IKIN@201174|Actinobacteria,4FJCU@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
TLS3_k127_4710093_11	1386089.N865_03265	3.298e-105	347.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4FEMT@85021|Intrasporangiaceae	201174|Actinobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_4710093_10	1035308.AQYY01000001_gene3214	5.667e-121	401.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_4710093_18	1123251.ATWM01000009_gene2944	5.474e-28	118.0	COG3467@1|root,COG3467@2|Bacteria,2IP5U@201174|Actinobacteria,4FGWT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
TLS3_k127_4710093_6	1385521.N803_05475	4.988e-175	558.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4FEVH@85021|Intrasporangiaceae	201174|Actinobacteria	EQ	5-oxoprolinase	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
TLS3_k127_4771527_2	367299.JOEE01000001_gene1757	5.073e-49	186.0	COG2197@1|root,COG2197@2|Bacteria,2HXJS@201174|Actinobacteria,4FH7N@85021|Intrasporangiaceae	201174|Actinobacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4771527_1	367299.JOEE01000001_gene1758	6.287e-252	796.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4FE3G@85021|Intrasporangiaceae	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
TLS3_k127_4771527_3	408672.NBCG_04597	1.002e-28	132.0	COG3557@1|root,COG3557@2|Bacteria,2IQ8M@201174|Actinobacteria,4DRXN@85009|Propionibacteriales	201174|Actinobacteria	J	Protein of unknown function (DUF402)	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
TLS3_k127_4771527_4	1210046.B277_07895	2.937e-18	87.0	28WQW@1|root,2ZIQK@2|Bacteria,2GX1R@201174|Actinobacteria	201174|Actinobacteria	S	Family of unknown function (DUF5302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5302
TLS3_k127_4771527_0	1386089.N865_05765	5.857e-252	790.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,4FEQ0@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA helicase	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C_2
TLS3_k127_4860003_6	313589.JNB_13473	7.669e-77	275.0	COG0515@1|root,COG0515@2|Bacteria,2GM4A@201174|Actinobacteria,4FEWE@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS3_k127_4860003_10	1386089.N865_11885	7.232e-53	213.0	COG1361@1|root,COG1361@2|Bacteria,2I7FT@201174|Actinobacteria,4FK24@85021|Intrasporangiaceae	201174|Actinobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4860003_3	313589.JNB_13478	1.838e-82	280.0	COG1051@1|root,COG1051@2|Bacteria,2I2DG@201174|Actinobacteria,4FEIH@85021|Intrasporangiaceae	201174|Actinobacteria	F	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_4860003_0	367299.JOEE01000002_gene2652	7.911e-244	762.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4FEKK@85021|Intrasporangiaceae	201174|Actinobacteria	J	RNA nucleotidyltransferase	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
TLS3_k127_4860003_7	1385519.N801_01560	4.484e-70	260.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4FFZG@85021|Intrasporangiaceae	201174|Actinobacteria	T	Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	BofC_C,PP2C,PP2C_2
TLS3_k127_4860003_13	1385518.N798_11360	6.367e-20	93.0	COG4770@1|root,COG4770@2|Bacteria,2I2DF@201174|Actinobacteria,4FJIB@85021|Intrasporangiaceae	201174|Actinobacteria	I	Biotin-lipoyl like	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
TLS3_k127_4860003_1	1121385.AQXW01000004_gene2702	2.44e-208	667.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,1ZVH6@145357|Dermacoccaceae	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
TLS3_k127_4860003_2	1385519.N801_12555	1.944e-206	668.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4FEIA@85021|Intrasporangiaceae	201174|Actinobacteria	M	Penicillin-binding Protein	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
TLS3_k127_4860003_9	1193181.BN10_480014	1.541e-57	216.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria,4FFXW@85021|Intrasporangiaceae	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS3_k127_4860003_4	1184609.KILIM_013_00050	1.219e-79	289.0	COG1073@1|root,COG1073@2|Bacteria,2I9HJ@201174|Actinobacteria	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
TLS3_k127_4860003_11	1385520.N802_05015	9.304e-44	169.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4FGY5@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
TLS3_k127_4860003_5	1210046.B277_05234	2.225e-79	269.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4FEK7@85021|Intrasporangiaceae	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS3_k127_4860003_12	1184607.AUCHE_18_00420	3.505e-36	139.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4F73J@85018|Dermatophilaceae	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
TLS3_k127_4860003_8	1385520.N802_05030	1.16e-59	221.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4FGB9@85021|Intrasporangiaceae	201174|Actinobacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
TLS3_k127_4866877_7	1121017.AUFG01000001_gene3096	6.061e-139	452.0	COG3132@1|root,COG4106@1|root,COG3132@2|Bacteria,COG4106@2|Bacteria,2I5BV@201174|Actinobacteria	201174|Actinobacteria	E	Protein of unknown function, DUF480	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480,Methyltransf_25
TLS3_k127_4866877_11	1043205.AFYF01000008_gene1576	1.325e-94	324.0	COG0523@1|root,COG0523@2|Bacteria,2HY1C@201174|Actinobacteria,4FJAP@85021|Intrasporangiaceae	201174|Actinobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C
TLS3_k127_4866877_18	1197906.CAJQ02000047_gene4077	7.932e-24	107.0	COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria,2UEPY@28211|Alphaproteobacteria,3K08M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4866877_1	1385518.N798_09975	1.766e-233	731.0	COG1249@1|root,COG1249@2|Bacteria,2GMP7@201174|Actinobacteria,4FEIX@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_4866877_6	1123251.ATWM01000006_gene2090	5.944e-146	468.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4FE87@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
TLS3_k127_4866877_2	1123251.ATWM01000006_gene2089	1.858e-204	665.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4FFJC@85021|Intrasporangiaceae	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
TLS3_k127_4866877_8	367299.JOEE01000003_gene3064	7.964e-138	444.0	COG0005@1|root,COG0005@2|Bacteria,2GKEI@201174|Actinobacteria,4FFHE@85021|Intrasporangiaceae	201174|Actinobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
TLS3_k127_4866877_0	1385520.N802_07085	1.263e-252	791.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,4FFTX@85021|Intrasporangiaceae	201174|Actinobacteria	G	phosphomannomutase	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_4866877_14	1385518.N798_10025	7.107e-71	257.0	COG4223@1|root,COG4223@2|Bacteria,2I390@201174|Actinobacteria,4FGF8@85021|Intrasporangiaceae	201174|Actinobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
TLS3_k127_4866877_17	1385518.N798_10030	1.038e-40	158.0	2CT9V@1|root,32SSX@2|Bacteria,2GKR6@201174|Actinobacteria,4FH9P@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
TLS3_k127_4866877_16	1385520.N802_07025	1.616e-54	207.0	29B69@1|root,2ZY4N@2|Bacteria,2GKQW@201174|Actinobacteria,4FGKC@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4350
TLS3_k127_4866877_4	1385519.N801_16980	3.931e-155	509.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4FEQS@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
TLS3_k127_4866877_5	313589.JNB_18173	3.149e-153	514.0	COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4FEEB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
TLS3_k127_4866877_9	313589.JNB_18163	2.28e-137	452.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria,4FFMB@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
TLS3_k127_4866877_15	367299.JOEE01000007_gene4	1.843e-66	239.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria,4FGD1@85021|Intrasporangiaceae	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS3_k127_4866877_13	1122622.ATWJ01000009_gene3262	5.424e-79	266.0	COG1503@1|root,COG1503@2|Bacteria,2HY1E@201174|Actinobacteria,4FJAR@85021|Intrasporangiaceae	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4866877_12	1122622.ATWJ01000009_gene3262	1.068e-91	305.0	COG1503@1|root,COG1503@2|Bacteria,2HY1E@201174|Actinobacteria,4FJAR@85021|Intrasporangiaceae	201174|Actinobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4866877_3	1385519.N801_09290	2.645e-172	546.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4FF0F@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
TLS3_k127_4866877_10	1193181.BN10_1190008	1.795e-120	390.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FEZI@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_4897103_3	1193181.BN10_680084	4.183e-104	340.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4FEZ8@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3708c	Semialdhyde_dh,Semialdhyde_dhC
TLS3_k127_4897103_5	765420.OSCT_1033	3.564e-17	85.0	2DRD4@1|root,33B9X@2|Bacteria,2G7IX@200795|Chloroflexi,377N6@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_4897103_4	1385518.N798_09280	5.503e-96	329.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4FEQ4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
TLS3_k127_4897103_1	273677.BW34_01899	1.114e-188	592.0	COG2515@1|root,COG2515@2|Bacteria,2GIV5@201174|Actinobacteria,4FPXJ@85023|Microbacteriaceae	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	acdS	-	3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270	-	R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
TLS3_k127_4897103_2	1193181.BN10_680092	5.671e-109	359.0	COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,4FFZB@85021|Intrasporangiaceae	201174|Actinobacteria	E	dimethylaminohydrolase	ddaH	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
TLS3_k127_4897103_0	1380370.JIBA01000003_gene2760	7.057e-315	994.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4FE2Y@85021|Intrasporangiaceae	201174|Actinobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,PPC,Peptidase_S8
TLS3_k127_4987952_1	1210046.B277_01819	5.654e-178	561.0	COG0039@1|root,COG0039@2|Bacteria,2GJHS@201174|Actinobacteria,4FEX3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
TLS3_k127_4987952_0	710696.Intca_0913	4.786e-253	802.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FG4H@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS3_k127_4987952_3	367299.JOEE01000007_gene25	1.152e-125	420.0	COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4FFX1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
TLS3_k127_4987952_2	1385521.N803_05610	3.683e-145	479.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4FFKS@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
TLS3_k127_4987952_4	367299.JOEE01000007_gene16	1.415e-57	222.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4FFI2@85021|Intrasporangiaceae	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS3_k127_5021991_8	1385518.N798_01590	1.099e-137	442.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria,4FEDI@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
TLS3_k127_5021991_30	1210046.B277_13119	2.027e-26	116.0	2DFMC@1|root,2ZS9Y@2|Bacteria,2ISH7@201174|Actinobacteria,4FH94@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4235
TLS3_k127_5021991_14	1210046.B277_13114	6.588e-82	282.0	COG4721@1|root,COG4721@2|Bacteria,2IDAN@201174|Actinobacteria,4FEYK@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter (Permease)	ykoE	-	-	ko:K16925	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.30	-	-	ABC_cobalt
TLS3_k127_5021991_1	1385521.N803_12720	9.758e-242	769.0	COG0619@1|root,COG1122@1|root,COG0619@2|Bacteria,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FESH@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter, ATP-binding protein	ykoD	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
TLS3_k127_5021991_3	1193181.BN10_790003	2.822e-153	495.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,4FF8W@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	MFS transporter permease	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_5021991_13	1089455.MOPEL_084_00440	1.894e-97	324.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4F6RX@85018|Dermatophilaceae	201174|Actinobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
TLS3_k127_5021991_22	1203190.CAJP01000025_gene151	1.148e-51	194.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,22N9H@1653|Corynebacteriaceae	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
TLS3_k127_5021991_10	1172188.KB911820_gene3151	3.753e-114	377.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4FE8E@85021|Intrasporangiaceae	201174|Actinobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
TLS3_k127_5021991_27	1184609.KILIM_110_00030	5.717e-39	152.0	COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria	201174|Actinobacteria	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
TLS3_k127_5021991_21	1121017.AUFG01000007_gene1324	2.85e-52	198.0	COG0561@1|root,COG0561@2|Bacteria,2IA5F@201174|Actinobacteria,4FIXF@85021|Intrasporangiaceae	201174|Actinobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS3_k127_5021991_9	1410634.JHVD01000024_gene522	5.658e-120	394.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,4DN4Z@85009|Propionibacteriales	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
TLS3_k127_5021991_2	1122622.ATWJ01000001_gene2587	3.898e-223	704.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FFF3@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	cotA	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
TLS3_k127_5021991_23	1122622.ATWJ01000001_gene2586	1.158e-41	160.0	COG0681@1|root,COG0681@2|Bacteria,2IQMY@201174|Actinobacteria,4FHKK@85021|Intrasporangiaceae	201174|Actinobacteria	U	Signal peptidase, peptidase S26	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
TLS3_k127_5021991_32	543632.JOJL01000023_gene1828	1.464e-10	73.0	COG2197@1|root,COG2197@2|Bacteria,2GJ5I@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_5021991_19	1122622.ATWJ01000001_gene2584	8.231e-61	229.0	COG3629@1|root,COG3629@2|Bacteria,2IP3I@201174|Actinobacteria,4FHJR@85021|Intrasporangiaceae	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Response_reg,Trans_reg_C
TLS3_k127_5021991_17	1193181.BN10_300071	6.207e-62	214.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria,4FH0J@85021|Intrasporangiaceae	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
TLS3_k127_5021991_31	1464048.JNZS01000011_gene4964	1.333e-21	99.0	2EBG9@1|root,335GU@2|Bacteria,2IJZI@201174|Actinobacteria,4DDQ4@85008|Micromonosporales	201174|Actinobacteria	S	sigma 54 modulation protein ribosomal protein S30EA	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
TLS3_k127_5021991_28	1123251.ATWM01000001_gene811	1.993e-38	145.0	COG4430@1|root,COG4430@2|Bacteria,2IQK3@201174|Actinobacteria	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
TLS3_k127_5021991_11	1122622.ATWJ01000007_gene1899	2.227e-111	372.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4FI54@85021|Intrasporangiaceae	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
TLS3_k127_5021991_4	1298863.AUEP01000001_gene1026	1.948e-151	488.0	COG0019@1|root,COG0019@2|Bacteria,2GRW6@201174|Actinobacteria,4DV2G@85009|Propionibacteriales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_9,Orn_Arg_deC_N,Orn_DAP_Arg_deC
TLS3_k127_5021991_7	1089455.MOPEL_084_00410	5.177e-144	469.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4F6VC@85018|Dermatophilaceae	201174|Actinobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_5021991_18	1193181.BN10_1090003	7.037e-61	212.0	COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,4FHIE@85021|Intrasporangiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
TLS3_k127_5021991_24	1089455.MOPEL_080_00080	1.678e-40	154.0	COG2329@1|root,COG2329@2|Bacteria,2IM1Q@201174|Actinobacteria,4F7ZG@85018|Dermatophilaceae	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	1.14.99.57	ko:K21481	-	-	-	-	ko00000,ko01000	-	-	-	ABM
TLS3_k127_5021991_0	367299.JOEE01000001_gene1716	0.0	1073.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4FEDJ@85021|Intrasporangiaceae	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
TLS3_k127_5021991_16	1385519.N801_06060	3.748e-66	234.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,4FH8C@85021|Intrasporangiaceae	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
TLS3_k127_5021991_6	1385518.N798_01425	3.043e-146	479.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4FECM@85021|Intrasporangiaceae	201174|Actinobacteria	O	molecular chaperone	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
TLS3_k127_5021991_20	1193181.BN10_800017	3.298e-56	205.0	COG0789@1|root,COG0789@2|Bacteria,2IQJ4@201174|Actinobacteria,4FH6B@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
TLS3_k127_5021991_5	1193181.BN10_800016	5.517e-150	487.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4FF6D@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknA	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS3_k127_5021991_12	1713.JOFV01000006_gene2790	2.651e-101	349.0	COG2234@1|root,COG2234@2|Bacteria,2HXYE@201174|Actinobacteria,4F1P4@85016|Cellulomonadaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS3_k127_5021991_29	1210046.B277_02848	6.265e-27	115.0	2EMIH@1|root,33F74@2|Bacteria,2GU9H@201174|Actinobacteria,4FHRU@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RraB
TLS3_k127_5021991_25	1341646.CBMO010000035_gene4570	1.169e-39	155.0	COG1280@1|root,COG1280@2|Bacteria,2HRC6@201174|Actinobacteria,233JW@1762|Mycobacteriaceae	201174|Actinobacteria	E	Sap, sulfolipid-1-addressing protein	-	-	-	-	-	-	-	-	-	-	-	-	SfLAP
TLS3_k127_5021991_15	367299.JOEE01000001_gene1721	2.064e-74	262.0	COG1030@1|root,COG1030@2|Bacteria,2IIZ2@201174|Actinobacteria,4FFCD@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	wcoO	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
TLS3_k127_5021991_26	684949.ATTJ01000001_gene3006	1.795e-39	147.0	COG2759@1|root,COG2759@2|Bacteria,1WJ6J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
TLS3_k127_5038298_1	1385519.N801_09560	6.642e-207	652.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4FEHQ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_5038298_12	1385518.N798_08265	3.467e-54	199.0	2AN86@1|root,31D67@2|Bacteria,2HWWU@201174|Actinobacteria,4FG05@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3043)	-	GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	-	-	-	-	-	-	-	-	-	DUF3043
TLS3_k127_5038298_15	1184609.KILIM_052_00090	2.085e-17	83.0	2BFAP@1|root,3293P@2|Bacteria,2HSUR@201174|Actinobacteria,4F7A5@85018|Dermatophilaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5038298_4	367299.JOEE01000004_gene1417	6.616e-186	589.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4FEBS@85021|Intrasporangiaceae	201174|Actinobacteria	E	glycine cleavage system	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
TLS3_k127_5038298_6	1193181.BN10_290004	5.172e-163	531.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FEMJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
TLS3_k127_5038298_13	446466.Cfla_2099	1.334e-33	136.0	2E6TR@1|root,331DK@2|Bacteria,2IQF8@201174|Actinobacteria,4F1GF@85016|Cellulomonadaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5038298_3	367299.JOEE01000004_gene1413	4.198e-195	619.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4FF17@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_5038298_5	1048339.KB913029_gene4655	1.29e-179	583.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4ERCG@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E2 component	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
TLS3_k127_5038298_9	367299.JOEE01000004_gene1411	3.605e-99	335.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4FEWU@85021|Intrasporangiaceae	201174|Actinobacteria	S	epimerase	-	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS3_k127_5038298_11	1385519.N801_19985	6.915e-69	265.0	COG0515@1|root,COG0515@2|Bacteria,2ID99@201174|Actinobacteria,4FGTW@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS3_k127_5038298_8	1385521.N803_06745	1.055e-111	378.0	COG3340@1|root,COG3340@2|Bacteria,2GZK5@201174|Actinobacteria,4FENP@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
TLS3_k127_5038298_7	367299.JOEE01000004_gene1406	9.595e-113	366.0	COG0321@1|root,COG0321@2|Bacteria,2GJIX@201174|Actinobacteria,4FFX5@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
TLS3_k127_5038298_2	710696.Intca_2025	5.169e-201	628.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4FECK@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
TLS3_k127_5038298_10	1193181.BN10_300098	5.644e-81	282.0	2DBPK@1|root,2ZA9M@2|Bacteria,2I87Y@201174|Actinobacteria,4FF2W@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4191
TLS3_k127_5038298_14	1386089.N865_07440	1.405e-32	132.0	COG1714@1|root,COG1714@2|Bacteria,2IQMG@201174|Actinobacteria,4FHT2@85021|Intrasporangiaceae	201174|Actinobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
TLS3_k127_5038298_0	1193181.BN10_300096	8.04e-300	927.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4FEXR@85021|Intrasporangiaceae	201174|Actinobacteria	E	glutamine synthetase	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS3_k127_5128487_5	367299.JOEE01000002_gene2352	5.315e-97	339.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4FG1A@85021|Intrasporangiaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
TLS3_k127_5128487_7	1385520.N802_02855	4.926e-59	218.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4FGYD@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
TLS3_k127_5128487_11	367299.JOEE01000002_gene2354	1.453e-38	162.0	2E27K@1|root,32XDT@2|Bacteria,2GRMM@201174|Actinobacteria,4FHXG@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5128487_4	313589.JNB_11284	7.407e-125	431.0	COG4995@1|root,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4FECT@85021|Intrasporangiaceae	201174|Actinobacteria	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
TLS3_k127_5128487_10	367299.JOEE01000003_gene2869	1.92e-43	168.0	2E4AX@1|root,32Z6K@2|Bacteria,2I0B2@201174|Actinobacteria,4FGYV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
TLS3_k127_5128487_9	313589.JNB_06279	8.235e-44	161.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4FH04@85021|Intrasporangiaceae	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
TLS3_k127_5128487_1	367299.JOEE01000003_gene2871	1.386e-239	746.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4FET6@85021|Intrasporangiaceae	201174|Actinobacteria	Q	homogentisate 12-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
TLS3_k127_5128487_3	1385518.N798_06795	8.082e-213	693.0	COG0179@1|root,COG0179@2|Bacteria,2GNGC@201174|Actinobacteria,4FF35@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Fumarylacetoacetase	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
TLS3_k127_5128487_8	1385518.N798_06800	1.248e-48	185.0	COG1714@1|root,COG1714@2|Bacteria,2HXE4@201174|Actinobacteria,4FGCN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2510)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
TLS3_k127_5128487_2	367299.JOEE01000003_gene2880	5.979e-237	737.0	COG3185@1|root,COG3185@2|Bacteria,2GNF0@201174|Actinobacteria,4FEYX@85021|Intrasporangiaceae	201174|Actinobacteria	E	4-hydroxyphenylpyruvate dioxygenase	hpd	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
TLS3_k127_5128487_6	1386089.N865_12110	5.538e-64	222.0	COG1522@1|root,COG1522@2|Bacteria,2H7NM@201174|Actinobacteria,4FGJD@85021|Intrasporangiaceae	201174|Actinobacteria	K	AsnC family transcriptional regulator	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS3_k127_5128487_14	1122622.ATWJ01000015_gene676	1.04e-10	68.0	2BK9H@1|root,32EPP@2|Bacteria,2HY3P@201174|Actinobacteria,4FJNJ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5128487_0	1385518.N798_06855	6.331e-290	899.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4FEPT@85021|Intrasporangiaceae	201174|Actinobacteria	L	Type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
TLS3_k127_5128487_12	590998.Celf_0979	4.082e-25	111.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_5128487_13	1120950.KB892742_gene2989	8.39e-21	93.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4DMZM@85009|Propionibacteriales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_5134534_3	477641.MODMU_3040	9.932e-38	152.0	2B3RV@1|root,31WFF@2|Bacteria,2GX6M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5134534_2	345341.KUTG_02417	9.375e-60	221.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4E2XH@85010|Pseudonocardiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
TLS3_k127_5134534_0	2074.JNYD01000007_gene1989	0.0	1053.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4EA77@85010|Pseudonocardiales	201174|Actinobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
TLS3_k127_5134534_1	1120948.KB903225_gene5544	1.175e-91	320.0	COG3011@1|root,COG3011@2|Bacteria,2GN4W@201174|Actinobacteria	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
TLS3_k127_5134534_5	1125971.ASJB01000028_gene7800	1.938e-12	79.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
TLS3_k127_5194061_30	1385520.N802_17720	8.131e-16	77.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4FGZE@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
TLS3_k127_5194061_21	405948.SACE_2204	1.083e-74	261.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4E044@85010|Pseudonocardiales	201174|Actinobacteria	BDLTU	PFAM Phosphatidylinositol 3- and 4-kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5194061_8	1385520.N802_17730	2.296e-157	508.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4FEEX@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
TLS3_k127_5194061_10	367299.JOEE01000008_gene629	1.375e-137	442.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4FFKZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Carboxylate--amine ligase	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
TLS3_k127_5194061_19	1385519.N801_11860	2.868e-83	283.0	COG0637@1|root,COG0637@2|Bacteria,2GJNG@201174|Actinobacteria,4FF3W@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
TLS3_k127_5194061_13	1386089.N865_13045	7.197e-120	391.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4FFDN@85021|Intrasporangiaceae	201174|Actinobacteria	L	Domain of unknown function DUF83	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
TLS3_k127_5194061_0	397278.JOJN01000004_gene1450	0.0	1804.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DP5M@85009|Propionibacteriales	201174|Actinobacteria	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
TLS3_k127_5194061_20	1385521.N803_08160	4.59e-77	271.0	COG1994@1|root,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4FGTA@85021|Intrasporangiaceae	201174|Actinobacteria	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
TLS3_k127_5194061_7	1210046.B277_01254	5.946e-167	531.0	COG1994@1|root,COG2519@1|root,COG1994@2|Bacteria,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4FFE1@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
TLS3_k127_5194061_2	1385518.N798_10915	3.563e-295	912.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4FE9Y@85021|Intrasporangiaceae	201174|Actinobacteria	O	AAA ATPase forming ring-shaped complexes	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
TLS3_k127_5194061_6	1385518.N798_10905	4.167e-175	557.0	COG0462@1|root,COG0462@2|Bacteria,2GKR2@201174|Actinobacteria,4FFIH@85021|Intrasporangiaceae	201174|Actinobacteria	EF	Ribose-phosphate pyrophosphokinase	prs_1	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
TLS3_k127_5194061_15	367299.JOEE01000008_gene619	3.539e-117	385.0	COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,4FG12@85021|Intrasporangiaceae	201174|Actinobacteria	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
TLS3_k127_5194061_3	1385518.N798_10895	2.483e-236	739.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4FEJ9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pup deamidase depupylase	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
TLS3_k127_5194061_28	1385520.N802_17820	1.12e-19	89.0	2E9C2@1|root,333JS@2|Bacteria,2IQ5V@201174|Actinobacteria,4FHFW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
TLS3_k127_5194061_12	313589.JNB_02960	1.639e-122	402.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4FE8W@85021|Intrasporangiaceae	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS3_k127_5194061_16	367299.JOEE01000008_gene615	3.171e-110	368.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4FFJS@85021|Intrasporangiaceae	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
TLS3_k127_5194061_23	367299.JOEE01000005_gene3479	2.549e-65	241.0	COG2268@1|root,COG2268@2|Bacteria,2GKTJ@201174|Actinobacteria,4FF1T@85021|Intrasporangiaceae	201174|Actinobacteria	S	Cellulose-binding protein	abpS	-	-	-	-	-	-	-	-	-	-	-	DivIVA
TLS3_k127_5194061_27	767029.HMPREF9154_0939	1.558e-20	106.0	COG3064@1|root,COG3064@2|Bacteria,2I109@201174|Actinobacteria,4DVJD@85009|Propionibacteriales	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5194061_5	1385519.N801_11950	7.924e-224	701.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4FEEG@85021|Intrasporangiaceae	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
TLS3_k127_5194061_22	367299.JOEE01000008_gene613	5.408e-74	264.0	COG0545@1|root,COG0545@2|Bacteria,2GJK2@201174|Actinobacteria,4FGBH@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans	fkbB	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
TLS3_k127_5194061_24	710696.Intca_1776	3.644e-61	212.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4FH87@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans	fkbP	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
TLS3_k127_5194061_11	1385518.N798_10850	1.425e-131	434.0	COG3502@1|root,COG3502@2|Bacteria,2H2JJ@201174|Actinobacteria,4FETG@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
TLS3_k127_5194061_14	269800.Tfu_1771	7.08e-119	406.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4EFRP@85012|Streptosporangiales	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
TLS3_k127_5194061_29	313589.JNB_02910	9.679e-17	86.0	COG1826@1|root,COG1826@2|Bacteria,2HXVI@201174|Actinobacteria,4FHXS@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
TLS3_k127_5194061_18	313589.JNB_02905	1.113e-89	303.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4FF5V@85021|Intrasporangiaceae	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
TLS3_k127_5194061_17	1385519.N801_11990	1.169e-99	340.0	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria,4FFRP@85021|Intrasporangiaceae	201174|Actinobacteria	I	Diacylglycerol kinase	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
TLS3_k127_5194061_1	367299.JOEE01000008_gene604	0.0	1293.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4FE6T@85021|Intrasporangiaceae	201174|Actinobacteria	L	RNA helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
TLS3_k127_5194061_9	367299.JOEE01000008_gene601	2.838e-139	449.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria,4FFA5@85021|Intrasporangiaceae	201174|Actinobacteria	L	5'-3' exonuclease	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
TLS3_k127_5194061_25	1193181.BN10_560043	6.25e-61	217.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,4FGPJ@85021|Intrasporangiaceae	201174|Actinobacteria	K	AsnC family transcriptional regulator	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS3_k127_5194061_26	1172188.KB911823_gene555	4.958e-60	212.0	COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,4FGM4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
TLS3_k127_5194061_4	1193181.BN10_560041	4.879e-225	699.0	COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria,4FF3K@85021|Intrasporangiaceae	201174|Actinobacteria	E	Lysine 2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_5235489_1	1454010.JEOE01000001_gene535	1.364e-295	911.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4F28Y@85016|Cellulomonadaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS3_k127_5235489_5	1193181.BN10_530006	3.711e-126	408.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4FEGJ@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
TLS3_k127_5235489_4	1122609.AUGT01000009_gene2979	5.317e-174	562.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4DN27@85009|Propionibacteriales	201174|Actinobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS3_k127_5235489_2	1172188.KB911824_gene3268	4.097e-214	685.0	COG1960@1|root,COG1960@2|Bacteria,2GM3V@201174|Actinobacteria,4FFCF@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7,1.3.8.8	ko:K00249,ko:K00255	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_5235489_7	1385518.N798_06610	7.654e-56	223.0	COG1309@1|root,COG1309@2|Bacteria,2GMNZ@201174|Actinobacteria,4FEPJ@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_5235489_6	1385519.N801_17655	2.778e-92	320.0	COG0500@1|root,COG2226@2|Bacteria,2HX63@201174|Actinobacteria,4FF0P@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_5235489_0	710696.Intca_1340	0.0	1046.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4FEAG@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter, ATP-binding protein	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_5235489_3	1043493.BBLU01000005_gene2044	5.19e-214	715.0	COG3391@1|root,COG3629@1|root,COG3391@2|Bacteria,COG3629@2|Bacteria,2I5UJ@201174|Actinobacteria	201174|Actinobacteria	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS3_k127_5235489_8	595593.JREV01000024_gene1449	1.333e-09	64.0	COG0629@1|root,COG0629@2|Bacteria,2GQIQ@201174|Actinobacteria	201174|Actinobacteria	L	single-stranded DNA-binding protein	ssb2	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
TLS3_k127_5236010_0	1385521.N803_02435	0.0	1988.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4FE2X@85021|Intrasporangiaceae	201174|Actinobacteria	C	part of alternative pathway from alpha-ketoglutarate to succinate	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
TLS3_k127_5236010_18	1385519.N801_07825	1.005e-23	107.0	2E460@1|root,32Z20@2|Bacteria,2GQGS@201174|Actinobacteria,4FHQE@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5236010_15	1193181.BN10_1470001	8.94e-62	222.0	COG2755@1|root,COG2755@2|Bacteria,2IA8J@201174|Actinobacteria,4FG1T@85021|Intrasporangiaceae	201174|Actinobacteria	E	G-D-S-L family lipolytic protein	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS3_k127_5236010_5	1380370.JIBA01000016_gene694	1.693e-138	447.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS3_k127_5236010_17	1283287.KB822581_gene1493	1.402e-37	151.0	COG0110@1|root,COG0110@2|Bacteria,2IDUP@201174|Actinobacteria,4DSHT@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
TLS3_k127_5236010_2	313589.JNB_07184	1.445e-183	591.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4FEA3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Malate dehydrogenase	mez_1	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
TLS3_k127_5236010_19	1385518.N798_09020	1.508e-20	98.0	COG0681@1|root,COG0681@2|Bacteria,2I5WW@201174|Actinobacteria,4FHRM@85021|Intrasporangiaceae	201174|Actinobacteria	U	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
TLS3_k127_5236010_13	1043205.AFYF01000058_gene2424	2.556e-68	234.0	293MU@1|root,2ZR3M@2|Bacteria,2IFCB@201174|Actinobacteria,4FGRY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Nickel-containing superoxide dismutase	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
TLS3_k127_5236010_10	1380370.JIBA01000014_gene2143	1.474e-73	262.0	COG2206@1|root,COG2206@2|Bacteria,2GJB1@201174|Actinobacteria,4FFSG@85021|Intrasporangiaceae	201174|Actinobacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
TLS3_k127_5236010_12	710696.Intca_2525	5.276e-72	260.0	COG3437@1|root,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4FGRR@85021|Intrasporangiaceae	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
TLS3_k127_5236010_20	1386089.N865_14930	6.281e-16	90.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4FHE6@85021|Intrasporangiaceae	201174|Actinobacteria	K	Putative zinc-finger	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS3_k127_5236010_9	1385520.N802_02565	1.606e-100	335.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4FF1Y@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_5236010_11	1385521.N803_02525	2.575e-73	250.0	COG1528@1|root,COG1528@2|Bacteria,2IG5S@201174|Actinobacteria,4FGTY@85021|Intrasporangiaceae	201174|Actinobacteria	P	Ferritin-like domain	bfrB	GO:0001666,GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0030312,GO:0033212,GO:0033214,GO:0036293,GO:0042592,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051235,GO:0051238,GO:0051409,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070482,GO:0071944,GO:0097577,GO:0098771	1.16.3.1	ko:K22336	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
TLS3_k127_5236010_16	1380356.JNIK01000019_gene373	1.205e-47	179.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,4ETGY@85013|Frankiales	201174|Actinobacteria	S	Hydrolase of the alpha beta-hydrolase	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
TLS3_k127_5236010_7	313589.JNB_07239	9.106e-127	411.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4FF9J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
TLS3_k127_5236010_14	1385519.N801_07910	1.19e-63	222.0	COG2259@1|root,COG2259@2|Bacteria,2HD6Y@201174|Actinobacteria,4FGKG@85021|Intrasporangiaceae	201174|Actinobacteria	S	DoxX family	doxX	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS3_k127_5236010_3	1385518.N798_08965	5.513e-181	576.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4FFKH@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
TLS3_k127_5236010_6	1385518.N798_08960	4.915e-133	439.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,4FEQ3@85021|Intrasporangiaceae	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
TLS3_k127_5236010_1	1385519.N801_07925	1.103e-199	631.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4FEBA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS3_k127_5236010_4	367299.JOEE01000004_gene945	6.275e-180	574.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4FEDF@85021|Intrasporangiaceae	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
TLS3_k127_5236010_8	367299.JOEE01000004_gene944	9.044e-119	386.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4FFXH@85021|Intrasporangiaceae	201174|Actinobacteria	EP	Peptide ABC transporter permease	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
TLS3_k127_524756_6	675635.Psed_1256	1.227e-49	179.0	COG4584@1|root,COG4584@2|Bacteria,2GZ8H@201174|Actinobacteria,4DYEV@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Integrase, catalytic core	istA	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
TLS3_k127_524756_1	405948.SACE_6452	4.693e-197	621.0	COG4584@1|root,COG4584@2|Bacteria,2HKD7@201174|Actinobacteria,4E7X4@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
TLS3_k127_524756_2	263358.VAB18032_04595	1.438e-145	468.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4DBWJ@85008|Micromonosporales	201174|Actinobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,UPF0114
TLS3_k127_524756_5	929712.KI912613_gene2771	2.549e-51	186.0	COG1733@1|root,COG1733@2|Bacteria,2GMQG@201174|Actinobacteria,4CQGV@84995|Rubrobacteria	84995|Rubrobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
TLS3_k127_524756_3	1173263.Syn7502_00340	1.166e-88	301.0	COG0300@1|root,COG0300@2|Bacteria,1G2JD@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
TLS3_k127_524756_4	756067.MicvaDRAFT_0994	2.755e-62	229.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_524756_0	1123024.AUII01000026_gene2542	1.96e-309	960.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4E08S@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
TLS3_k127_524756_8	105422.BBPM01000058_gene4579	1.076e-06	56.0	COG1595@1|root,COG1595@2|Bacteria,2GKBH@201174|Actinobacteria,2NG2Y@228398|Streptacidiphilus	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
TLS3_k127_524756_7	675635.Psed_5542	2.864e-11	72.0	COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,2IEEA@201174|Actinobacteria,4E8EQ@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
TLS3_k127_5255069_7	1385518.N798_14865	3.856e-36	144.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4FEEZ@85021|Intrasporangiaceae	201174|Actinobacteria	O	Fe-S cluster assembly	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
TLS3_k127_5255069_3	313589.JNB_03365	3.01e-78	269.0	COG2345@1|root,COG2345@2|Bacteria,2GN8W@201174|Actinobacteria,4FGFY@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	sufR	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
TLS3_k127_5255069_1	367299.JOEE01000005_gene3596	8.293e-115	381.0	COG1183@1|root,COG1183@2|Bacteria,2I3MV@201174|Actinobacteria,4FFTA@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
TLS3_k127_5255069_5	1385518.N798_14840	6.039e-71	254.0	COG0688@1|root,COG0688@2|Bacteria,2GMMF@201174|Actinobacteria,4FFIR@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
TLS3_k127_5255069_2	1193181.BN10_1080013	1.083e-84	287.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4FEK6@85021|Intrasporangiaceae	201174|Actinobacteria	V	Multidrug ABC transporter ATPase	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
TLS3_k127_5255069_4	367299.JOEE01000005_gene3594	8.551e-76	269.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4FGAN@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
TLS3_k127_5255069_0	1385519.N801_11495	7.538e-116	381.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4FG1S@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
TLS3_k127_5255069_6	367299.JOEE01000005_gene3588	3.328e-48	174.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4FEY1@85021|Intrasporangiaceae	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
TLS3_k127_5273637_14	1184609.KILIM_061_00250	1.653e-104	342.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4F6QE@85018|Dermatophilaceae	201174|Actinobacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TLS3_k127_5273637_6	313589.JNB_13818	6.588e-139	449.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4FF5C@85021|Intrasporangiaceae	201174|Actinobacteria	S	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_5273637_18	1385518.N798_11680	2.061e-43	171.0	COG5340@1|root,COG5340@2|Bacteria,2GS2C@201174|Actinobacteria,4FJ4S@85021|Intrasporangiaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS3_k127_5273637_11	1184609.KILIM_061_00140	6.583e-107	359.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria	201174|Actinobacteria	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_5273637_2	1386089.N865_00340	4.12e-182	574.0	COG1082@1|root,COG1082@2|Bacteria,2GK1S@201174|Actinobacteria,4FE3Z@85021|Intrasporangiaceae	201174|Actinobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS3_k127_5273637_1	1386089.N865_00335	1.322e-200	631.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria,4FEVC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_5273637_5	1184609.KILIM_008_00070	9.905e-145	477.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4F615@85018|Dermatophilaceae	201174|Actinobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS3_k127_5273637_4	1184609.KILIM_008_00130	1.697e-152	486.0	COG1082@1|root,COG1082@2|Bacteria,2GMU1@201174|Actinobacteria,4F71T@85018|Dermatophilaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	iolH	-	-	ko:K06605	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
TLS3_k127_5273637_3	1386089.N865_00505	4.691e-171	541.0	COG1082@1|root,COG1082@2|Bacteria,2GJKJ@201174|Actinobacteria,4FG6M@85021|Intrasporangiaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS3_k127_5273637_12	1193181.BN10_10007	1.554e-106	350.0	COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,4FF5B@85021|Intrasporangiaceae	201174|Actinobacteria	K	GntR family transcriptional regulator	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS3_k127_5273637_7	1089455.MOPEL_083_00150	1.389e-133	434.0	COG0524@1|root,COG0524@2|Bacteria,2GM3N@201174|Actinobacteria,4F6PG@85018|Dermatophilaceae	201174|Actinobacteria	G	pfkB family carbohydrate kinase	iolC	-	2.7.1.92	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R05661	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS3_k127_5273637_10	1172188.KB911822_gene900	3.082e-117	388.0	COG1830@1|root,COG1830@2|Bacteria,2GKTN@201174|Actinobacteria,4FF3U@85021|Intrasporangiaceae	201174|Actinobacteria	G	Deoxyribose-phosphate aldolase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5273637_13	367299.JOEE01000001_gene1501	4.775e-105	367.0	COG3718@1|root,COG3718@2|Bacteria,2GM8S@201174|Actinobacteria,4FFG9@85021|Intrasporangiaceae	201174|Actinobacteria	G	5-deoxyglucuronate isomerase	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
TLS3_k127_5273637_8	1386089.N865_04785	1.097e-123	422.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4FFPX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_5273637_0	367299.JOEE01000001_gene1504	9.005e-285	884.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4FFGS@85021|Intrasporangiaceae	201174|Actinobacteria	C	methylmalonate-semialdehyde dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_5273637_9	1386089.N865_00465	4.579e-122	401.0	COG3622@1|root,COG3622@2|Bacteria,2GKPC@201174|Actinobacteria,4FG9C@85021|Intrasporangiaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS3_k127_5273637_15	743718.Isova_2032	1.69e-80	275.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria,4F5JZ@85017|Promicromonosporaceae	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
TLS3_k127_5273637_16	644283.Micau_1285	4.873e-71	264.0	arCOG07533@1|root,3167U@2|Bacteria,2INR8@201174|Actinobacteria,4DMXK@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
TLS3_k127_5273637_17	547163.BN979_01368	1.682e-56	199.0	COG3832@1|root,COG3832@2|Bacteria,2IHY4@201174|Actinobacteria,239FM@1762|Mycobacteriaceae	201174|Actinobacteria	E	polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_5314891_5	1385520.N802_09065	1.738e-137	446.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4FEM0@85021|Intrasporangiaceae	201174|Actinobacteria	BQ	acetoin utilization protein	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
TLS3_k127_5314891_12	1385520.N802_09070	6.693e-96	318.0	COG0569@1|root,COG0569@2|Bacteria,2IA09@201174|Actinobacteria,4FECF@85021|Intrasporangiaceae	201174|Actinobacteria	P	Potassium	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS3_k127_5314891_17	1172188.KB911826_gene57	8.734e-62	225.0	COG0454@1|root,COG0456@2|Bacteria,2IHG4@201174|Actinobacteria,4FGF4@85021|Intrasporangiaceae	201174|Actinobacteria	K	N-acetyltransferase GCN5	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_5314891_18	367299.JOEE01000001_gene2007	1.484e-37	149.0	COG0454@1|root,COG0456@2|Bacteria,2HXG9@201174|Actinobacteria,4FGIR@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_5314891_8	1385520.N802_09090	1.197e-124	409.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4FE2V@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
TLS3_k127_5314891_6	1193181.BN10_1210009	9.283e-136	451.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria,4FEKP@85021|Intrasporangiaceae	201174|Actinobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
TLS3_k127_5314891_13	1210046.B277_00930	4.321e-86	295.0	COG1597@1|root,COG1597@2|Bacteria,2GNTZ@201174|Actinobacteria,4FHDT@85021|Intrasporangiaceae	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
TLS3_k127_5314891_15	1122622.ATWJ01000009_gene3369	5.974e-71	244.0	COG0662@1|root,COG0662@2|Bacteria,2IMPE@201174|Actinobacteria,4FGSG@85021|Intrasporangiaceae	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_5314891_11	1385520.N802_09110	1.017e-118	391.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria,4FEA7@85021|Intrasporangiaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
TLS3_k127_5314891_7	1385518.N798_13685	1.827e-127	415.0	COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria,4FFTZ@85021|Intrasporangiaceae	201174|Actinobacteria	FP	Ppx/GppA phosphatase family	ppx1	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS3_k127_5314891_4	1385518.N798_13680	9.47e-142	454.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria,4FENC@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5314891_14	266940.Krad_0607	1.412e-78	271.0	COG0500@1|root,COG2226@2|Bacteria,2GQ64@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
TLS3_k127_5314891_1	926560.KE387023_gene1701	4.568e-192	640.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF3365,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
TLS3_k127_5314891_16	1429916.X566_10960	2.828e-70	261.0	COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,1QW6N@1224|Proteobacteria,2TWQ3@28211|Alphaproteobacteria,3JU8D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,GAF_2,Guanylate_cyc,HAMP,dCache_1
TLS3_k127_5314891_0	367299.JOEE01000001_gene1472	1.479e-195	623.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4FF4M@85021|Intrasporangiaceae	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
TLS3_k127_5314891_2	367299.JOEE01000001_gene1473	2.837e-175	556.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4FE5W@85021|Intrasporangiaceae	201174|Actinobacteria	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
TLS3_k127_5314891_9	1385519.N801_12510	2.64e-123	412.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4FE8M@85021|Intrasporangiaceae	201174|Actinobacteria	L	Adenine glycosylase	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
TLS3_k127_5314891_10	367299.JOEE01000001_gene1484	7.183e-121	415.0	COG0308@1|root,COG0308@2|Bacteria,2ID1N@201174|Actinobacteria,4FIRF@85021|Intrasporangiaceae	201174|Actinobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5314891_3	1385518.N798_13005	1.262e-151	482.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4FES5@85021|Intrasporangiaceae	201174|Actinobacteria	O	ATP-dependent Clp protease	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
TLS3_k127_5390139_1	367299.JOEE01000003_gene3041	1.879e-218	690.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4FEGH@85021|Intrasporangiaceae	201174|Actinobacteria	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	yngE	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
TLS3_k127_5390139_2	367299.JOEE01000003_gene3042	4.22e-214	670.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4FEKW@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE19	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
TLS3_k127_5390139_9	367299.JOEE01000003_gene3043	1.616e-61	216.0	COG0789@1|root,COG0789@2|Bacteria,2IMV1@201174|Actinobacteria,4FH15@85021|Intrasporangiaceae	201174|Actinobacteria	K	MerR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
TLS3_k127_5390139_12	1385520.N802_07170	6.133e-09	63.0	2BKXF@1|root,32FDZ@2|Bacteria,2GZDJ@201174|Actinobacteria,4FI2I@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5390139_6	313589.JNB_18323	2.574e-136	441.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4FE30@85021|Intrasporangiaceae	201174|Actinobacteria	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS3_k127_5390139_3	1385518.N798_09930	6.503e-158	521.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4FHBD@85021|Intrasporangiaceae	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_5390139_10	367299.JOEE01000003_gene3050	3.844e-43	166.0	COG4929@1|root,COG4929@2|Bacteria,2IP6A@201174|Actinobacteria,4FJ4Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
TLS3_k127_5390139_8	1385520.N802_07105	2.332e-86	300.0	COG4872@1|root,COG4872@2|Bacteria,2IGZY@201174|Actinobacteria,4FI50@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
TLS3_k127_5390139_5	251229.Chro_2457	9.978e-139	466.0	COG2939@1|root,COG2939@2|Bacteria,1G45M@1117|Cyanobacteria	1117|Cyanobacteria	E	Peptidase, S10 (Carboxypeptidase Y) family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
TLS3_k127_5390139_4	1184609.KILIM_033_00290	8.409e-154	507.0	COG0616@1|root,COG0616@2|Bacteria,2HQDG@201174|Actinobacteria,4F7S4@85018|Dermatophilaceae	201174|Actinobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
TLS3_k127_5390139_7	1385518.N798_09940	5.906e-117	382.0	COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria,4FEXY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Aldo/keto reductase family	-	-	1.1.1.346	ko:K06221	-	-	R08878	RC00089	ko00000,ko01000	-	-	-	Aldo_ket_red
TLS3_k127_5390139_0	367299.JOEE01000003_gene3054	0.0	1006.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4FFCM@85021|Intrasporangiaceae	201174|Actinobacteria	I	carboxylase	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
TLS3_k127_5390139_11	1442599.JAAN01000001_gene2149	1.044e-14	83.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1X48D@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
TLS3_k127_5398718_4	367299.JOEE01000012_gene3224	9.842e-130	419.0	COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4FEAQ@85021|Intrasporangiaceae	201174|Actinobacteria	DT	RIO1 family	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
TLS3_k127_5398718_5	367299.JOEE01000012_gene3222	6.773e-122	400.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4FENB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
TLS3_k127_5398718_12	1292020.H483_0105210	5.904e-44	163.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
TLS3_k127_5398718_14	1101188.KI912157_gene301	1.259e-30	135.0	COG0347@1|root,COG0347@2|Bacteria,2I7AK@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5398718_13	1396858.Q666_07310	1.183e-37	150.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,466ZD@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
TLS3_k127_5398718_6	1396858.Q666_07310	7.466e-118	391.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,466ZD@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
TLS3_k127_5398718_15	443218.AS9A_1549	5.792e-21	101.0	COG1320@1|root,COG1320@2|Bacteria,2GQG4@201174|Actinobacteria	201174|Actinobacteria	P	monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
TLS3_k127_5398718_10	443218.AS9A_1550	4.025e-47	188.0	COG2111@1|root,COG2111@2|Bacteria	2|Bacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
TLS3_k127_5398718_17	1123507.ATVQ01000003_gene622	1.886e-13	79.0	COG1006@1|root,COG1006@2|Bacteria,2GSHQ@201174|Actinobacteria,1WBYV@1268|Micrococcaceae	201174|Actinobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
TLS3_k127_5398718_7	1292020.H483_0101835	3.767e-107	364.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS3_k127_5398718_1	1292020.H483_0101840	1.485e-176	580.0	COG0651@1|root,COG0651@2|Bacteria,2I6CT@201174|Actinobacteria	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
TLS3_k127_5398718_2	1292020.H483_0101845	3.069e-154	528.0	COG0651@1|root,COG0651@2|Bacteria,2IB44@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
TLS3_k127_5398718_16	443218.AS9A_1555	1.935e-18	94.0	COG1863@1|root,COG1863@2|Bacteria,2IRM2@201174|Actinobacteria	201174|Actinobacteria	P	Na+/H+ ion antiporter subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
TLS3_k127_5398718_8	1385520.N802_12270	2.945e-85	289.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4FGQH@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidoglycan-binding	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
TLS3_k127_5398718_3	1385518.N798_11560	2.325e-143	462.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4FE7E@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	mcl2	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI,PEP-utilizers_C
TLS3_k127_5398718_0	367299.JOEE01000012_gene3219	6.323e-213	663.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4FE3W@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
TLS3_k127_5398718_11	1385519.N801_19575	1.314e-45	171.0	2E6WZ@1|root,331GF@2|Bacteria,2IFC6@201174|Actinobacteria,4FGUR@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5398718_9	1385521.N803_02900	9.287e-73	251.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4FF03@85021|Intrasporangiaceae	201174|Actinobacteria	P	transporter	mgtE	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
TLS3_k127_5500418_5	1306174.JODP01000004_gene1203	3.792e-63	218.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
TLS3_k127_5500418_1	700508.D174_13260	1.844e-138	449.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,236CP@1762|Mycobacteriaceae	201174|Actinobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
TLS3_k127_5500418_0	656024.FsymDg_2441	3.328e-319	992.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4ERGD@85013|Frankiales	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
TLS3_k127_5500418_3	1035308.AQYY01000002_gene333	1.106e-94	328.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,260CU@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase,QueC
TLS3_k127_5500418_4	1385519.N801_12125	2.96e-83	285.0	COG1691@1|root,COG1691@2|Bacteria,2IAKU@201174|Actinobacteria,4FGAY@85021|Intrasporangiaceae	201174|Actinobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
TLS3_k127_5500418_2	710696.Intca_2472	9.752e-109	368.0	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria,4FE4D@85021|Intrasporangiaceae	201174|Actinobacteria	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
TLS3_k127_5500418_6	935866.JAER01000003_gene1304	7.37e-11	66.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,4DMZA@85009|Propionibacteriales	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_5513364_9	367299.JOEE01000006_gene870	1.934e-11	68.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,4FEPE@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_5513364_4	710696.Intca_0158	4.477e-122	407.0	COG1806@1|root,COG1806@2|Bacteria,2IAGN@201174|Actinobacteria,4FG7X@85021|Intrasporangiaceae	201174|Actinobacteria	H	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
TLS3_k127_5513364_5	367299.JOEE01000006_gene872	2.649e-70	244.0	COG1556@1|root,COG1556@2|Bacteria,2GNUJ@201174|Actinobacteria,4FGDM@85021|Intrasporangiaceae	201174|Actinobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
TLS3_k127_5513364_0	367299.JOEE01000006_gene873	3.912e-261	820.0	COG1139@1|root,COG1139@2|Bacteria,2GJDR@201174|Actinobacteria,4FED8@85021|Intrasporangiaceae	201174|Actinobacteria	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
TLS3_k127_5513364_3	313589.JNB_14078	8.541e-129	416.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4FE79@85021|Intrasporangiaceae	201174|Actinobacteria	C	Fe-S osidoreductase	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
TLS3_k127_5513364_1	1193181.BN10_1000001	1.297e-229	714.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4FG41@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
TLS3_k127_5513364_6	1210046.B277_03705	1.359e-49	188.0	COG1506@1|root,COG1506@2|Bacteria,2I3Z4@201174|Actinobacteria,4FFYZ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Abhydrolase_6,Peptidase_S9
TLS3_k127_5513364_7	526225.Gobs_1334	1.083e-40	156.0	2EJRI@1|root,33DGB@2|Bacteria,2ISBS@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
TLS3_k127_5513364_2	1120959.ATXF01000005_gene985	2.743e-171	557.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
TLS3_k127_5513364_8	28444.JODQ01000008_gene1045	8.235e-37	162.0	COG3544@1|root,COG3544@2|Bacteria,2IKUE@201174|Actinobacteria,4EJD4@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
TLS3_k127_5573021_2	1184609.KILIM_061_00260	1.26e-161	519.0	COG4214@1|root,COG4214@2|Bacteria,2I2DE@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_5573021_7	1370121.AUWS01000069_gene268	2.992e-93	318.0	COG1879@1|root,COG1879@2|Bacteria,2GKIJ@201174|Actinobacteria,23D5Z@1762|Mycobacteriaceae	201174|Actinobacteria	G	Periplasmic binding protein domain	iolTA	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
TLS3_k127_5573021_0	1172188.KB911822_gene902	0.0	1037.0	COG3962@1|root,COG3962@2|Bacteria,2GMCJ@201174|Actinobacteria,4FEHU@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_5573021_4	1385521.N803_11570	1.735e-138	448.0	COG1082@1|root,COG1082@2|Bacteria,2GJKJ@201174|Actinobacteria,4FFFM@85021|Intrasporangiaceae	201174|Actinobacteria	G	Inosose dehydratase	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS3_k127_5573021_5	1122622.ATWJ01000011_gene2339	4.057e-127	421.0	COG4671@1|root,COG4671@2|Bacteria,2IAST@201174|Actinobacteria,4FHN0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
TLS3_k127_5573021_3	1043205.AFYF01000051_gene3016	2.435e-140	459.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4FG8S@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
TLS3_k127_5573021_6	1122622.ATWJ01000011_gene2337	2.733e-116	406.0	COG0438@1|root,COG0438@2|Bacteria,2ID3T@201174|Actinobacteria,4FGBI@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
TLS3_k127_5573021_1	1043205.AFYF01000051_gene3014	7.783e-213	676.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4FG74@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
TLS3_k127_5573021_9	1120944.JONS01000001_gene2034	1.315e-27	128.0	COG2334@1|root,COG2334@2|Bacteria,2HJS8@201174|Actinobacteria,4D42K@85005|Actinomycetales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_5573021_8	1122622.ATWJ01000011_gene2334	6.15e-61	228.0	COG2334@1|root,COG2334@2|Bacteria,2IKR1@201174|Actinobacteria,4FHZ2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_5614426_33	543632.JOJL01000001_gene7747	9.834e-34	140.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,RDD
TLS3_k127_5614426_17	1193181.BN10_1070031	1.159e-116	381.0	COG1595@1|root,COG1595@2|Bacteria,2GJIZ@201174|Actinobacteria,4FEQM@85021|Intrasporangiaceae	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_5614426_35	1184609.KILIM_015_00600	1.829e-29	125.0	2CFVG@1|root,3346Y@2|Bacteria,2GRCI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
TLS3_k127_5614426_31	68223.JNZY01000020_gene7114	3.342e-51	185.0	28M3Q@1|root,2ZAHT@2|Bacteria,2GM5B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5614426_28	1380393.JHVP01000006_gene3940	1.305e-65	232.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4EV0P@85013|Frankiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS3_k127_5614426_36	1274.HX89_03640	5.319e-29	126.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,1ZVJ4@145357|Dermacoccaceae	201174|Actinobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
TLS3_k127_5614426_30	1380370.JIBA01000001_gene2168	9e-54	200.0	COG2166@1|root,COG2166@2|Bacteria,2IMBF@201174|Actinobacteria,4FGIP@85021|Intrasporangiaceae	201174|Actinobacteria	S	Fe-S metabolism associated domain	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
TLS3_k127_5614426_4	1380370.JIBA01000001_gene2169	2.941e-159	505.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4FF7F@85021|Intrasporangiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	sseA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS3_k127_5614426_6	479431.Namu_0961	4.545e-144	478.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,4ESGN@85013|Frankiales	201174|Actinobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3332	Amidohydro_1
TLS3_k127_5614426_11	931627.MycrhDRAFT_2167	2.268e-127	411.0	COG0363@1|root,COG0363@2|Bacteria,2GK7F@201174|Actinobacteria,237IY@1762|Mycobacteriaceae	201174|Actinobacteria	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion	nagB	-	3.5.99.6	ko:K02564,ko:K02804	ko00520,ko01100,ko02060,map00520,map01100,map02060	M00267	R00765,R05199	RC00017,RC00163,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	Glucosamine_iso
TLS3_k127_5614426_0	110319.CF8_3263	0.0	1027.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,2GKPM@201174|Actinobacteria,4DT51@85009|Propionibacteriales	201174|Actinobacteria	G	Phosphotransferase system, EIIC	nagE	-	2.7.1.193	ko:K02802,ko:K02803,ko:K02804	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
TLS3_k127_5614426_18	110319.CF8_3264	2.655e-106	350.0	COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,4DT3T@85009|Propionibacteriales	201174|Actinobacteria	K	UTRA	dasR	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS3_k127_5614426_1	1122622.ATWJ01000001_gene2575	8.056e-215	676.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4FFM4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_5614426_9	1122622.ATWJ01000001_gene2574	3.015e-136	449.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4FFW0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TLS3_k127_5614426_8	1380347.JNII01000007_gene534	6.892e-142	456.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4EUCM@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5614426_38	644107.SL1157_1307	4.443e-22	104.0	COG1226@1|root,COG1226@2|Bacteria,1NH49@1224|Proteobacteria,2UENB@28211|Alphaproteobacteria,4NCRV@97050|Ruegeria	28211|Alphaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS3_k127_5614426_12	1121017.AUFG01000010_gene1601	1.957e-125	407.0	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,4FGB6@85021|Intrasporangiaceae	201174|Actinobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_5614426_27	1172185.KB911514_gene4235	6.359e-67	256.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FW35@85025|Nocardiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,GerE,Trans_reg_C
TLS3_k127_5614426_20	290400.Jann_3671	4.827e-99	334.0	COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,2TURU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	homocysteine	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
TLS3_k127_5614426_16	543632.JOJL01000005_gene4754	8.559e-118	390.0	COG2066@1|root,COG2066@2|Bacteria,2GKAV@201174|Actinobacteria,4DDJY@85008|Micromonosporales	201174|Actinobacteria	E	Glutaminase	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
TLS3_k127_5614426_34	1380394.JADL01000003_gene5015	1.539e-31	137.0	COG1917@1|root,COG1917@2|Bacteria,1RDGQ@1224|Proteobacteria,2U994@28211|Alphaproteobacteria,2JTFJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant	ectC	-	4.2.1.108	ko:K06720	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06979	RC01729	ko00000,ko00001,ko00002,ko01000	-	-	-	Ectoine_synth
TLS3_k127_5614426_32	710696.Intca_0077	1.334e-48	181.0	COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4FGRT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB_2
TLS3_k127_5614426_24	926564.KI911759_gene4706	7.471e-73	251.0	COG1280@1|root,COG1280@2|Bacteria,2GMDP@201174|Actinobacteria,4F4DG@85017|Promicromonosporaceae	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
TLS3_k127_5614426_3	645465.ACUR01000575_gene1390	2.052e-175	561.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_5614426_19	223184.AS25_08735	2.189e-103	349.0	COG2124@1|root,COG2124@2|Bacteria,2HETU@201174|Actinobacteria,1W90T@1268|Micrococcaceae	201174|Actinobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_5614426_5	1089455.MOPEL_001_00330	2.06e-148	474.0	COG0667@1|root,COG0667@2|Bacteria,2GJ6R@201174|Actinobacteria,4F7D2@85018|Dermatophilaceae	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_5614426_21	1089455.MOPEL_060_00080	2.232e-83	293.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4F7DD@85018|Dermatophilaceae	201174|Actinobacteria	CG	Glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
TLS3_k127_5614426_13	1429046.RR21198_2819	1.677e-124	413.0	COG2197@1|root,COG2197@2|Bacteria,2GPKD@201174|Actinobacteria,4FYKY@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GerE
TLS3_k127_5614426_23	1122622.ATWJ01000012_gene890	2.22e-77	265.0	COG3945@1|root,COG3945@2|Bacteria,2IKF0@201174|Actinobacteria,4FGYI@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS3_k127_5614426_2	1035308.AQYY01000001_gene3001	4.315e-179	572.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
TLS3_k127_5614426_14	1385519.N801_14990	1.247e-122	408.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4FGIJ@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_5614426_37	1029824.AFID01000012_gene1204	1.878e-23	107.0	COG1514@1|root,COG1514@2|Bacteria,2IFPP@201174|Actinobacteria,1WA7F@1268|Micrococcaceae	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS3_k127_5614426_7	1172188.KB911826_gene149	6.501e-142	465.0	COG1233@1|root,COG1233@2|Bacteria,2HX8Z@201174|Actinobacteria,4FFVH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
TLS3_k127_5614426_10	1385520.N802_02185	1.22e-127	430.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS3_k127_5614426_15	1385520.N802_02185	3.184e-119	404.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS3_k127_5614426_22	1122182.KB903833_gene5401	3.367e-83	313.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
TLS3_k127_5614426_29	1385520.N802_02180	3.352e-61	223.0	COG0664@1|root,COG0664@2|Bacteria,2IGTB@201174|Actinobacteria,4FGI1@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_5614426_39	66869.JNXG01000003_gene3243	7.096e-19	93.0	COG2203@1|root,COG2203@2|Bacteria,2I97I@201174|Actinobacteria,41AHV@629295|Streptomyces griseus group	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
TLS3_k127_5614426_25	1370125.AUWT01000032_gene1634	2.928e-72	253.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
TLS3_k127_5614426_26	1122221.JHVI01000018_gene1496	1.647e-68	238.0	COG2374@1|root,COG2374@2|Bacteria,1WM95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
TLS3_k127_57039_5	1380370.JIBA01000004_gene2300	5.641e-14	81.0	2DRPJ@1|root,33CGW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_57039_3	1123251.ATWM01000006_gene2152	4.511e-130	422.0	COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria,4FEQR@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
TLS3_k127_57039_0	1385518.N798_02195	3.598e-223	702.0	COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria,4FEB2@85021|Intrasporangiaceae	201174|Actinobacteria	C	NAD(P) transhydrogenase subunit alpha	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
TLS3_k127_57039_1	1386089.N865_15780	3.468e-218	685.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4FECY@85021|Intrasporangiaceae	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
TLS3_k127_57039_2	367299.JOEE01000001_gene2065	2.65e-149	485.0	COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria,4FFAM@85021|Intrasporangiaceae	201174|Actinobacteria	C	D-arabinono-1,4-lactone oxidase	gulo	-	1.1.3.8	ko:K00103	ko00053,ko01100,map00053,map01100	M00129	R00647,R03184,R10053	RC00195,RC00346,RC00869	ko00000,ko00001,ko00002,ko01000	-	-	-	ALO,FAD_binding_4
TLS3_k127_57039_4	1122622.ATWJ01000011_gene2261	1.576e-24	114.0	COG3428@1|root,COG3428@2|Bacteria,2IA1C@201174|Actinobacteria,4FH42@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
TLS3_k127_5890140_1	1210046.B277_00160	3.377e-222	703.0	COG4166@1|root,COG4166@2|Bacteria,2GIUH@201174|Actinobacteria,4FE56@85021|Intrasporangiaceae	201174|Actinobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
TLS3_k127_5890140_6	313589.JNB_07284	9.008e-121	394.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4FF9X@85021|Intrasporangiaceae	201174|Actinobacteria	G	Inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS3_k127_5890140_5	1385519.N801_07955	2.84e-159	517.0	COG0612@1|root,COG0612@2|Bacteria,2GKAT@201174|Actinobacteria,4FEX7@85021|Intrasporangiaceae	201174|Actinobacteria	S	protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_5890140_4	367299.JOEE01000004_gene938	1.489e-186	591.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4FEE1@85021|Intrasporangiaceae	201174|Actinobacteria	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
TLS3_k127_5890140_2	1386089.N865_06805	8.604e-212	669.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4FENQ@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADH dehydrogenase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
TLS3_k127_5890140_3	1440774.Y900_015075	3.965e-203	636.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,236DQ@1762|Mycobacteriaceae	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_5890140_0	1121017.AUFG01000019_gene2387	2.276e-295	919.0	COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,2GMYR@201174|Actinobacteria	201174|Actinobacteria	G	PTS system mannitol-specific	mtlA	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
TLS3_k127_5890140_8	1122247.C731_4959	9.349e-34	136.0	COG1522@1|root,COG1522@2|Bacteria,2HSQU@201174|Actinobacteria,23DK3@1762|Mycobacteriaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
TLS3_k127_5890140_7	469383.Cwoe_2557	1.245e-114	389.0	COG0531@1|root,COG0531@2|Bacteria,2GJ1D@201174|Actinobacteria,4CQ5R@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM amino acid permease-associated region	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
TLS3_k127_5890140_9	1122918.KB907247_gene4691	3.626e-07	54.0	2EIAV@1|root,33C29@2|Bacteria,1VMAE@1239|Firmicutes,4HRG9@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5986270_5	1121017.AUFG01000010_gene1640	4.588e-07	55.0	2DKZU@1|root,311IQ@2|Bacteria,2HY1Q@201174|Actinobacteria,4FJDE@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_5986270_4	1385519.N801_15060	7.236e-91	305.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4FE9T@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
TLS3_k127_5986270_0	1121017.AUFG01000013_gene1966	2.545e-194	621.0	COG0770@1|root,COG0770@2|Bacteria,2I2EU@201174|Actinobacteria,4FFSA@85021|Intrasporangiaceae	201174|Actinobacteria	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
TLS3_k127_5986270_3	1184609.KILIM_065_00250	2.015e-111	365.0	COG3442@1|root,COG3442@2|Bacteria,2GKPV@201174|Actinobacteria,4F640@85018|Dermatophilaceae	201174|Actinobacteria	S	CobB/CobQ-like glutamine amidotransferase domain	cobQ2	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
TLS3_k127_5986270_2	1385519.N801_18685	1.026e-145	471.0	COG0392@1|root,COG0392@2|Bacteria,2ICMJ@201174|Actinobacteria,4FF3J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS3_k127_5986270_1	1385519.N801_18680	1.068e-191	609.0	COG0438@1|root,COG0438@2|Bacteria,2HEX9@201174|Actinobacteria,4FFWE@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_6032630_18	1122609.AUGT01000034_gene766	2.91e-08	61.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,4DMZA@85009|Propionibacteriales	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_6032630_2	1122622.ATWJ01000013_gene104	3.924e-211	662.0	COG1819@1|root,COG1819@2|Bacteria,2HEXA@201174|Actinobacteria,4FFXB@85021|Intrasporangiaceae	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
TLS3_k127_6032630_0	1122622.ATWJ01000013_gene103	3.018e-235	746.0	COG0438@1|root,COG1413@1|root,COG0438@2|Bacteria,COG1413@2|Bacteria,2HMNV@201174|Actinobacteria,4FFZP@85021|Intrasporangiaceae	201174|Actinobacteria	CM	Glycosyltransferase Family 4	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1,HEAT_2
TLS3_k127_6032630_17	512565.AMIS_28770	1.91e-08	60.0	COG0572@1|root,COG0572@2|Bacteria,2GMCP@201174|Actinobacteria,4D8TG@85008|Micromonosporales	201174|Actinobacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TLS3_k127_6032630_7	570268.ANBB01000019_gene4414	1.674e-50	194.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,Methyltransf_21,Methyltransf_24
TLS3_k127_6032630_14	47763.JNZA01000066_gene6893	2.071e-21	108.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria	201174|Actinobacteria	E	Cholesterol oxidase	choD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N
TLS3_k127_6032630_19	1121381.JNIV01000083_gene115	0.0001413	51.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	AAA_18,PRK,Thymidylate_kin
TLS3_k127_6032630_5	1386089.N865_18920	9.019e-59	205.0	COG1742@1|root,COG1742@2|Bacteria,2IKM8@201174|Actinobacteria,4FH5F@85021|Intrasporangiaceae	201174|Actinobacteria	S	UPF0060 membrane protein	-	GO:0005575,GO:0005576	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
TLS3_k127_6032630_11	1064537.AGSO01000003_gene1217	8.642e-36	146.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_6032630_12	649831.L083_5852	1.775e-32	130.0	2EB9B@1|root,3359U@2|Bacteria,2GSA6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_6032630_3	1122622.ATWJ01000009_gene3375	8.369e-147	483.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4FG1Z@85021|Intrasporangiaceae	201174|Actinobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
TLS3_k127_6032630_13	1122933.JNIY01000003_gene186	2.803e-32	147.0	2B3ZZ@1|root,31WQ4@2|Bacteria,2GXQG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6032630_8	319795.Dgeo_1745	1.525e-43	160.0	COG2343@1|root,COG2343@2|Bacteria,1WN4Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS3_k127_6032630_9	1210046.B277_00395	2.711e-38	147.0	COG3439@1|root,COG3439@2|Bacteria,2IKVF@201174|Actinobacteria,4FH0R@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
TLS3_k127_6032630_1	1283299.AUKG01000006_gene806	3.404e-214	674.0	COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,4CRY7@84995|Rubrobacteria	84995|Rubrobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,Pyr_redox_3
TLS3_k127_6032630_6	863239.AFIZ01000014_gene1379	2.406e-53	208.0	2AVWZ@1|root,31MQX@2|Bacteria,2IGS0@201174|Actinobacteria,22RFV@1653|Corynebacteriaceae	201174|Actinobacteria	S	GXWXG protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4334,GXWXG
TLS3_k127_6032630_4	479431.Namu_3806	1.976e-134	445.0	COG2866@1|root,COG2866@2|Bacteria,2GN49@201174|Actinobacteria,4EV6P@85013|Frankiales	201174|Actinobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
TLS3_k127_6032630_10	1120958.AULD01000015_gene1329	4.745e-37	140.0	COG1064@1|root,COG1064@2|Bacteria,2GNNY@201174|Actinobacteria,4FMYI@85023|Microbacteriaceae	201174|Actinobacteria	S	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_6033406_11	675635.Psed_6299	1.072e-35	142.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4E1HN@85010|Pseudonocardiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
TLS3_k127_6033406_8	1048339.KB913029_gene4090	5.187e-48	175.0	2E4PM@1|root,32ZI9@2|Bacteria,2IMT3@201174|Actinobacteria,4EVYJ@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6033406_9	1380347.JNII01000006_gene1617	1.238e-47	189.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria	201174|Actinobacteria	CG	Glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
TLS3_k127_6033406_17	446470.Snas_3795	5.127e-13	77.0	COG1309@1|root,COG1309@2|Bacteria,2IKQ8@201174|Actinobacteria,4EZQS@85014|Glycomycetales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_6033406_15	710696.Intca_3492	4.512e-21	99.0	COG4101@1|root,COG4101@2|Bacteria,2II42@201174|Actinobacteria,4FGN5@85021|Intrasporangiaceae	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_6033406_6	1037409.BJ6T_23800	5.593e-58	210.0	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2U0MC@28211|Alphaproteobacteria,3JTRU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
TLS3_k127_6033406_0	2074.JNYD01000032_gene6494	3.206e-127	422.0	COG2141@1|root,COG2141@2|Bacteria,2H89R@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_6033406_2	1108045.GORHZ_136_00050	1.018e-123	411.0	COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria,4GDE8@85026|Gordoniaceae	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6033406_7	1108045.GORHZ_136_00060	1.105e-56	211.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
TLS3_k127_6033406_14	953739.SVEN_2464	1.719e-21	107.0	2B4YS@1|root,31XRR@2|Bacteria,2GZH7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6033406_13	2074.JNYD01000007_gene1965	4.034e-23	112.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
TLS3_k127_6033406_12	1120948.KB903226_gene5481	1.483e-26	116.0	COG5485@1|root,COG5485@2|Bacteria,2I3RT@201174|Actinobacteria,4EF7Q@85010|Pseudonocardiales	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS3_k127_6033406_16	99598.Cal7507_5639	1.05e-17	89.0	COG0662@1|root,COG0662@2|Bacteria,1G6EN@1117|Cyanobacteria,1HQB6@1161|Nostocales	1117|Cyanobacteria	G	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_6033406_3	479431.Namu_0278	5.384e-118	391.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4EU45@85013|Frankiales	201174|Actinobacteria	M	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
TLS3_k127_6033406_10	1110697.NCAST_05_01730	2.437e-40	162.0	2BVJ9@1|root,32QX8@2|Bacteria,2IITD@201174|Actinobacteria,4G72R@85025|Nocardiaceae	201174|Actinobacteria	S	ankyrin repeats	-	-	-	-	-	-	-	-	-	-	-	-	Ank_5
TLS3_k127_6033406_4	2074.JNYD01000013_gene6978	4.877e-90	319.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,4E11Q@85010|Pseudonocardiales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Lactonase,Pkinase
TLS3_k127_6033406_5	2074.JNYD01000015_gene4498	2.736e-59	221.0	COG3503@1|root,COG3503@2|Bacteria,2I2JM@201174|Actinobacteria,4E008@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
TLS3_k127_6033842_9	1193181.BN10_900032	2.373e-29	121.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4FEI3@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
TLS3_k127_6033842_2	1184609.KILIM_077_00240	4.103e-159	514.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4F6CV@85018|Dermatophilaceae	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
TLS3_k127_6033842_5	1089455.MOPEL_009_00110	3.096e-104	352.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4F72M@85018|Dermatophilaceae	201174|Actinobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
TLS3_k127_6033842_3	561175.KB894099_gene5026	3.639e-149	488.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4EI2C@85012|Streptosporangiales	201174|Actinobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
TLS3_k127_6033842_6	367299.JOEE01000001_gene1548	6.214e-101	339.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4FHJS@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_6033842_4	367299.JOEE01000001_gene1578	2.394e-110	368.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria,4FGGM@85021|Intrasporangiaceae	201174|Actinobacteria	H	Polyprenyl synthetase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,polyprenyl_synt
TLS3_k127_6033842_0	367299.JOEE01000001_gene1577	3.486e-216	682.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4FFFU@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
TLS3_k127_6033842_1	367299.JOEE01000001_gene1576	2.377e-201	638.0	COG1443@1|root,COG1562@1|root,COG1443@2|Bacteria,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4FFGI@85021|Intrasporangiaceae	201174|Actinobacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
TLS3_k127_6033842_7	367299.JOEE01000001_gene1573	3.001e-72	261.0	COG0500@1|root,COG2226@2|Bacteria,2HFM8@201174|Actinobacteria,4FH8F@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	crtT	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
TLS3_k127_6045860_39	1499967.BAYZ01000019_gene6321	1.58e-25	108.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	MIase
TLS3_k127_6045860_40	1172188.KB911820_gene2194	1.729e-23	109.0	2EQUW@1|root,33IEN@2|Bacteria,2GQQ7@201174|Actinobacteria,4FJK9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6045860_45	1385519.N801_03200	2.811e-07	61.0	COG2337@1|root,COG2337@2|Bacteria,2ISBP@201174|Actinobacteria,4FHBG@85021|Intrasporangiaceae	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	mazF3	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS3_k127_6045860_24	1122609.AUGT01000024_gene359	3.065e-57	222.0	COG1309@1|root,COG1309@2|Bacteria,2IJP2@201174|Actinobacteria,4DSE4@85009|Propionibacteriales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
TLS3_k127_6045860_18	1122609.AUGT01000024_gene360	3.63e-62	218.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Cupin_2
TLS3_k127_6045860_35	575540.Isop_1232	9.402e-31	126.0	COG3613@1|root,COG3613@2|Bacteria,2J1JH@203682|Planctomycetes	203682|Planctomycetes	F	Nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
TLS3_k127_6045860_36	1032480.MLP_45310	3.046e-30	121.0	COG4710@1|root,COG4710@2|Bacteria	2|Bacteria	DJ	CopG domain protein DNA-binding domain protein	-	-	-	ko:K18918	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1,RHH_3,TraY
TLS3_k127_6045860_32	858619.CVAR_1431	4.763e-39	146.0	COG2026@1|root,COG2026@2|Bacteria,2GSVC@201174|Actinobacteria,22PA7@1653|Corynebacteriaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
TLS3_k127_6045860_26	1385521.N803_14895	3.075e-53	210.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
TLS3_k127_6045860_16	443218.AS9A_3039	1.656e-83	289.0	28JSF@1|root,314RP@2|Bacteria,2HDA9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6045860_5	1380370.JIBA01000011_gene3047	1.601e-172	545.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4FFEX@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS3_k127_6045860_43	1385521.N803_15130	8.989e-20	91.0	COG1669@1|root,COG1669@2|Bacteria,2GTPC@201174|Actinobacteria	201174|Actinobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
TLS3_k127_6045860_38	1385521.N803_15135	2.603e-27	118.0	COG2361@1|root,COG2361@2|Bacteria,2HGZ3@201174|Actinobacteria,4FJE3@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
TLS3_k127_6045860_25	1386089.N865_20860	2.831e-55	196.0	COG2337@1|root,COG2337@2|Bacteria,2IM6R@201174|Actinobacteria,4FH3Y@85021|Intrasporangiaceae	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS3_k127_6045860_44	1068980.ARVW01000001_gene5669	1.126e-17	84.0	COG3609@1|root,COG3609@2|Bacteria,2GS33@201174|Actinobacteria,4E7DS@85010|Pseudonocardiales	201174|Actinobacteria	K	addiction module antidote protein, CC2985 family	-	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS3_k127_6045860_20	710696.Intca_3496	4.924e-58	205.0	COG2337@1|root,COG2337@2|Bacteria,2HY4S@201174|Actinobacteria,4FJRX@85021|Intrasporangiaceae	201174|Actinobacteria	L	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
TLS3_k127_6045860_41	1386089.N865_20845	3.99e-20	96.0	2EM5W@1|root,33EV5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
TLS3_k127_6045860_22	710696.Intca_0352	8.626e-58	203.0	COG3654@1|root,COG3654@2|Bacteria,2IR34@201174|Actinobacteria,4FHP3@85021|Intrasporangiaceae	201174|Actinobacteria	S	Fic/DOC family	doc	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
TLS3_k127_6045860_42	1380370.JIBA01000011_gene3047	6.161e-20	97.0	COG4974@1|root,COG4974@2|Bacteria,2ID5W@201174|Actinobacteria,4FFEX@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
TLS3_k127_6045860_29	1123226.KB899283_gene3278	6.661e-42	165.0	COG2039@1|root,COG2039@2|Bacteria,1TRRX@1239|Firmicutes,4HCIJ@91061|Bacilli,26WF6@186822|Paenibacillaceae	91061|Bacilli	O	5-oxoproline from various penultimate amino acid residues except L-proline	pcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
TLS3_k127_6045860_9	1385520.N802_09670	8.08e-140	473.0	COG0477@1|root,COG0477@2|Bacteria,2IIAH@201174|Actinobacteria,4FK06@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_6045860_0	1385521.N803_04705	0.0	1352.0	COG1112@1|root,COG1198@1|root,COG2852@1|root,COG1112@2|Bacteria,COG1198@2|Bacteria,COG2852@2|Bacteria,2GKJW@201174|Actinobacteria,4FE4S@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF4011
TLS3_k127_6045860_33	367299.JOEE01000006_gene887	8.161e-38	148.0	COG1970@1|root,COG1970@2|Bacteria,2IQDN@201174|Actinobacteria,4FH68@85021|Intrasporangiaceae	201174|Actinobacteria	M	mechanosensitive channel	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
TLS3_k127_6045860_12	1386089.N865_09580	3.969e-118	387.0	COG0005@1|root,COG0005@2|Bacteria,2GKGG@201174|Actinobacteria,4FFIJ@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
TLS3_k127_6045860_37	1223543.GP2_003_01510	2.346e-28	119.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,4GEYG@85026|Gordoniaceae	201174|Actinobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
TLS3_k127_6045860_6	367299.JOEE01000006_gene892	4.092e-168	551.0	COG3263@1|root,COG3263@2|Bacteria,2GJ9B@201174|Actinobacteria,4FFKQ@85021|Intrasporangiaceae	201174|Actinobacteria	P	Potassium transporter CPA	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
TLS3_k127_6045860_2	1385521.N803_04670	1.077e-321	1005.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4FER7@85021|Intrasporangiaceae	201174|Actinobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
TLS3_k127_6045860_30	367299.JOEE01000006_gene894	1.932e-41	160.0	COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4FH14@85021|Intrasporangiaceae	201174|Actinobacteria	H	5-formyltetrahydrofolate cyclo-ligase	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
TLS3_k127_6045860_4	1385519.N801_03130	8.176e-175	563.0	COG4284@1|root,COG4284@2|Bacteria,2I2G3@201174|Actinobacteria,4FEYE@85021|Intrasporangiaceae	201174|Actinobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	ugpA	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
TLS3_k127_6045860_10	1385519.N801_03125	1.258e-130	430.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4FF2H@85021|Intrasporangiaceae	201174|Actinobacteria	H	molybdopterin	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
TLS3_k127_6045860_17	1172188.KB911825_gene3791	2.652e-70	247.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4FGBG@85021|Intrasporangiaceae	201174|Actinobacteria	H	Molybdenum cofactor biosynthesis protein MoaC	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
TLS3_k127_6045860_19	367299.JOEE01000006_gene898	1.914e-60	213.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4FGHH@85021|Intrasporangiaceae	201174|Actinobacteria	H	Molybdenum cofactor synthesis protein	mog	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
TLS3_k127_6045860_21	1193181.BN10_630010	5.718e-58	211.0	COG1670@1|root,COG1670@2|Bacteria,2HAFI@201174|Actinobacteria,4FEBM@85021|Intrasporangiaceae	201174|Actinobacteria	J	N-acetyltransferase GCN5	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
TLS3_k127_6045860_34	1385519.N801_03105	5.251e-37	153.0	2EEES@1|root,3388S@2|Bacteria,2HXRZ@201174|Actinobacteria,4FHMY@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6045860_14	313589.JNB_16928	2.792e-105	361.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4FEA0@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K20469	-	-	-	-	ko00000,ko02000	2.A.86.1.7	-	-	AI-2E_transport
TLS3_k127_6045860_46	1146883.BLASA_1078	0.0008282	42.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4ESQP@85013|Frankiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	int	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
TLS3_k127_6045860_15	37919.EP51_12495	2.527e-89	302.0	COG4221@1|root,COG4221@2|Bacteria,2GP17@201174|Actinobacteria,4FXIB@85025|Nocardiaceae	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_6045860_31	105420.BBPO01000031_gene6590	2.225e-39	154.0	COG0789@1|root,COG0789@2|Bacteria,2IC98@201174|Actinobacteria,2NGH2@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
TLS3_k127_6045860_28	526225.Gobs_3706	3.218e-47	175.0	COG0662@1|root,COG0662@2|Bacteria,2IEY0@201174|Actinobacteria,4EWAI@85013|Frankiales	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
TLS3_k127_6045860_3	1209072.ALBT01000077_gene410	6.061e-225	711.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1FFU7@10|Cellvibrio	1236|Gammaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0050896,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
TLS3_k127_6045860_7	521096.Tpau_1855	2.687e-158	504.0	COG0604@1|root,COG0604@2|Bacteria,2GK7Y@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_6045860_13	1068978.AMETH_4022	1.156e-114	386.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4DXPM@85010|Pseudonocardiales	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_6045860_23	1274.HX89_03530	2.412e-57	210.0	COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria,1ZWTZ@145357|Dermacoccaceae	201174|Actinobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
TLS3_k127_6045860_8	1122622.ATWJ01000014_gene373	7.057e-140	451.0	COG1948@1|root,COG1948@2|Bacteria,2HAMQ@201174|Actinobacteria,4FF1Z@85021|Intrasporangiaceae	201174|Actinobacteria	L	ERCC4 domain	-	-	-	-	-	-	-	-	-	-	-	-	ERCC4,Lsr2
TLS3_k127_6045860_1	367299.JOEE01000007_gene234	0.0	1241.0	COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,2GMX8@201174|Actinobacteria,4FFN8@85021|Intrasporangiaceae	201174|Actinobacteria	L	nuclease	-	-	-	-	-	-	-	-	-	-	-	-	AAA_12,AAA_30,RNase_H_2
TLS3_k127_6045860_11	1122622.ATWJ01000009_gene3145	4.347e-123	402.0	COG1432@1|root,COG1432@2|Bacteria,2HB6H@201174|Actinobacteria,4FFNZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
TLS3_k127_6045860_27	1184607.AUCHE_16_00330	5.114e-48	179.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria,4F7X4@85018|Dermatophilaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.2.1.8,3.5.1.104	ko:K01181,ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS3_k127_6048176_7	1193181.BN10_400001	1.525e-50	184.0	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4FF8E@85021|Intrasporangiaceae	201174|Actinobacteria	CO	ABC transporter, ATP-binding protein	cydC	-	-	ko:K06148,ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
TLS3_k127_6048176_8	1385521.N803_15025	5.09e-40	152.0	COG3682@1|root,COG3682@2|Bacteria,2IIIT@201174|Actinobacteria,4FHMJ@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	blaI	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
TLS3_k127_6048176_5	1172188.KB911822_gene1004	7.507e-60	218.0	COG0501@1|root,COG0501@2|Bacteria,2GM27@201174|Actinobacteria,4FFE9@85021|Intrasporangiaceae	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
TLS3_k127_6048176_2	1385520.N802_09895	1.56e-114	385.0	COG1432@1|root,COG1432@2|Bacteria,2GKEJ@201174|Actinobacteria,4FFVC@85021|Intrasporangiaceae	201174|Actinobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
TLS3_k127_6048176_6	1122622.ATWJ01000008_gene2978	1.852e-55	196.0	COG3651@1|root,COG3651@2|Bacteria,2IHNI@201174|Actinobacteria,4FH7J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
TLS3_k127_6048176_3	1193181.BN10_1390014	7.636e-74	253.0	COG0394@1|root,COG0394@2|Bacteria,2IM0Q@201174|Actinobacteria,4FGSB@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0035335,GO:0035821,GO:0036211,GO:0042578,GO:0043170,GO:0043207,GO:0043412,GO:0044003,GO:0044046,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052046,GO:0052047,GO:0052048,GO:0052083,GO:0052155,GO:0052173,GO:0052200,GO:0052212,GO:0052255,GO:0052278,GO:0052294,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:0140096,GO:1901564	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
TLS3_k127_6048176_4	312284.A20C1_01846	1.53e-66	254.0	COG2247@1|root,COG2247@2|Bacteria,2IG1A@201174|Actinobacteria	201174|Actinobacteria	M	Putative cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,GSDH
TLS3_k127_6048176_0	1385519.N801_14590	7.004e-263	817.0	COG0015@1|root,COG0015@2|Bacteria,2GM71@201174|Actinobacteria,4FE78@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes two discrete reactions in the de novo synthesis of purines the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
TLS3_k127_6048176_1	367299.JOEE01000002_gene2603	1.081e-146	469.0	COG3000@1|root,COG3000@2|Bacteria,2GMF0@201174|Actinobacteria,4FGHB@85021|Intrasporangiaceae	201174|Actinobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
TLS3_k127_6091169_13	1380356.JNIK01000016_gene3488	4.72e-44	167.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
TLS3_k127_6091169_3	1122622.ATWJ01000009_gene3268	1.796e-169	538.0	COG0189@1|root,COG0189@2|Bacteria,2IA42@201174|Actinobacteria	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	RimK
TLS3_k127_6091169_16	110319.CF8_1645	1.224e-24	107.0	COG0776@1|root,COG0776@2|Bacteria,2IKQR@201174|Actinobacteria,4DSEF@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the bacterial histone-like protein family	hup	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS3_k127_6091169_8	1122622.ATWJ01000014_gene419	8.5e-80	273.0	COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria,4FIFT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
TLS3_k127_6091169_14	1146883.BLASA_1350	1.64e-33	138.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,4EWWC@85013|Frankiales	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
TLS3_k127_6091169_12	196162.Noca_4952	2.431e-44	174.0	COG0785@1|root,COG0785@2|Bacteria,2I8T6@201174|Actinobacteria,4DTS6@85009|Propionibacteriales	201174|Actinobacteria	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
TLS3_k127_6091169_1	1386089.N865_00265	3.298e-210	668.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4FFH2@85021|Intrasporangiaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
TLS3_k127_6091169_9	196162.Noca_2090	4.372e-64	224.0	COG1595@1|root,COG1595@2|Bacteria,2GJG2@201174|Actinobacteria,4DUNY@85009|Propionibacteriales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_6091169_15	196162.Noca_2089	1.111e-30	132.0	28VJA@1|root,2ZHMR@2|Bacteria,2GQW5@201174|Actinobacteria,4DVW8@85009|Propionibacteriales	201174|Actinobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
TLS3_k127_6091169_6	1385520.N802_05880	1.834e-99	334.0	COG2755@1|root,COG2755@2|Bacteria,2IPPH@201174|Actinobacteria,4FI1E@85021|Intrasporangiaceae	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS3_k127_6091169_17	1386089.N865_14270	3.05e-17	86.0	arCOG10456@1|root,2ZA6T@2|Bacteria,2IT80@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6091169_10	471853.Bcav_2713	7.936e-53	189.0	COG0346@1|root,COG0346@2|Bacteria,2IKCC@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6091169_7	1033730.CAHG01000014_gene1857	2.574e-81	275.0	arCOG05626@1|root,2Z9D9@2|Bacteria,2IIAB@201174|Actinobacteria,4DSNX@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6091169_5	525904.Tter_1321	1.111e-108	359.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
TLS3_k127_6091169_2	768671.ThimaDRAFT_2660	9.075e-171	551.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,1WXBE@135613|Chromatiales	135613|Chromatiales	P	PFAM Sodium sulphate symporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
TLS3_k127_6091169_4	1120944.JONS01000040_gene9	3.259e-124	422.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria,4D3NQ@85005|Actinomycetales	201174|Actinobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
TLS3_k127_6091169_11	936548.HMPREF1136_1140	6.533e-52	203.0	COG0784@1|root,COG0784@2|Bacteria,2GQS0@201174|Actinobacteria,4D53Y@85005|Actinomycetales	201174|Actinobacteria	T	Response regulator receiver domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_6091169_0	1385520.N802_04255	2.291e-291	929.0	COG0477@1|root,COG0664@1|root,COG1752@1|root,COG0477@2|Bacteria,COG0664@2|Bacteria,COG1752@2|Bacteria,2GMEJ@201174|Actinobacteria,4FJVQ@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Belongs to the major facilitator superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	MFS_1,MFS_3,Patatin,Sugar_tr,cNMP_binding
TLS3_k127_6094787_24	367299.JOEE01000004_gene1192	1.307e-108	355.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4FE4N@85021|Intrasporangiaceae	201174|Actinobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
TLS3_k127_6094787_19	367299.JOEE01000004_gene1197	5.642e-131	425.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4FE89@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
TLS3_k127_6094787_29	1385518.N798_04270	3.713e-89	299.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4FF1S@85021|Intrasporangiaceae	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
TLS3_k127_6094787_26	1385521.N803_17255	3.233e-102	342.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria,4FEKX@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
TLS3_k127_6094787_8	1386089.N865_10110	1.693e-199	641.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4FFMX@85021|Intrasporangiaceae	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
TLS3_k127_6094787_17	367299.JOEE01000004_gene1202	3.336e-142	466.0	COG2010@1|root,COG2010@2|Bacteria,2GN1Q@201174|Actinobacteria,4FESY@85021|Intrasporangiaceae	201174|Actinobacteria	C	Copper type II ascorbate-dependent monooxygenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C,Cu2_monooxygen
TLS3_k127_6094787_16	367299.JOEE01000004_gene1203	1.215e-145	470.0	COG1611@1|root,COG1611@2|Bacteria,2GPA4@201174|Actinobacteria,4FETS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Rossmann fold nucleotide-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
TLS3_k127_6094787_10	367299.JOEE01000004_gene1204	2.103e-183	593.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4FFMD@85021|Intrasporangiaceae	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS3_k127_6094787_1	367299.JOEE01000004_gene1205	3.092e-268	829.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4FE6A@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	tpa	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
TLS3_k127_6094787_32	367299.JOEE01000004_gene1206	1.177e-70	246.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4FGCJ@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS3_k127_6094787_2	1193181.BN10_840022	2.126e-258	806.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FFRV@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_6094787_12	710696.Intca_2253	1.181e-178	569.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4FEPY@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG0687 Spermidine putrescine-binding periplasmic protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
TLS3_k127_6094787_15	710696.Intca_2252	3.142e-158	511.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4FEJ5@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS3_k127_6094787_20	710696.Intca_2251	6.2e-131	427.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4FFEP@85021|Intrasporangiaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS3_k127_6094787_18	710696.Intca_2250	3.718e-132	426.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4FEZB@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS3_k127_6094787_5	367299.JOEE01000004_gene1212	4.919e-229	719.0	COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria,4FFH8@85021|Intrasporangiaceae	201174|Actinobacteria	E	COG1748 Saccharopine dehydrogenase and related	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
TLS3_k127_6094787_9	1193181.BN10_840016	3.763e-193	615.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4FJBN@85021|Intrasporangiaceae	201174|Actinobacteria	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
TLS3_k127_6094787_3	367299.JOEE01000004_gene1213	1.458e-249	776.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FESA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_6094787_25	1386089.N865_09995	1.382e-105	353.0	COG0305@1|root,COG0305@2|Bacteria,2I9NH@201174|Actinobacteria,4FER9@85021|Intrasporangiaceae	201174|Actinobacteria	L	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_C
TLS3_k127_6094787_11	367299.JOEE01000004_gene1215	1.209e-181	578.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4FE8R@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
TLS3_k127_6094787_13	1385519.N801_13290	1.165e-177	568.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4FEQK@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidase family M50	rip1	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
TLS3_k127_6094787_4	1385520.N802_19345	6.097e-231	718.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4FFFS@85021|Intrasporangiaceae	201174|Actinobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
TLS3_k127_6094787_27	367299.JOEE01000004_gene1220	6.907e-101	336.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4FFWK@85021|Intrasporangiaceae	201174|Actinobacteria	S	Acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
TLS3_k127_6094787_31	1210046.B277_12201	1.125e-83	286.0	COG0454@1|root,COG0456@2|Bacteria,2INZ5@201174|Actinobacteria,4FGZC@85021|Intrasporangiaceae	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_6094787_30	1122611.KB903958_gene4037	2.25e-88	298.0	COG0491@1|root,COG0607@1|root,COG0730@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,COG0730@2|Bacteria,2GN50@201174|Actinobacteria,4EG8M@85012|Streptosporangiales	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
TLS3_k127_6094787_0	367299.JOEE01000004_gene1226	0.0	1029.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4FETC@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
TLS3_k127_6094787_22	1385520.N802_19385	1.176e-123	401.0	COG1011@1|root,COG1011@2|Bacteria,2HX5F@201174|Actinobacteria,4FEU4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
TLS3_k127_6094787_23	1385518.N798_04120	2.424e-123	404.0	COG0730@1|root,COG0730@2|Bacteria,2GMNQ@201174|Actinobacteria,4FFDD@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_6094787_6	1043205.AFYF01000058_gene2491	1.037e-225	713.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,4FFNW@85021|Intrasporangiaceae	201174|Actinobacteria	P	inorganic phosphate transporter	pitB	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	iNJ661.Rv2281	PHO4
TLS3_k127_6094787_7	398580.Dshi_0543	2.143e-202	646.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Na phosphate symporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
TLS3_k127_6094787_28	1385520.N802_19525	1.572e-98	346.0	COG3570@1|root,COG3570@2|Bacteria,2GNSH@201174|Actinobacteria,4FEBW@85021|Intrasporangiaceae	201174|Actinobacteria	V	Aminoglycoside/hydroxyurea antibiotic resistance kinase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
TLS3_k127_6094787_34	1385519.N801_00080	2.275e-36	152.0	2B38P@1|root,31VWS@2|Bacteria,2GPWE@201174|Actinobacteria,4FHIM@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4439
TLS3_k127_6094787_33	313589.JNB_20318	1.061e-43	164.0	COG0779@1|root,COG0779@2|Bacteria,2I9BT@201174|Actinobacteria,4FHAV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
TLS3_k127_6094787_14	367299.JOEE01000004_gene1245	1.358e-165	533.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4FECC@85021|Intrasporangiaceae	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
TLS3_k127_6094787_35	1385521.N803_17595	3.809e-23	107.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,4FHW1@85021|Intrasporangiaceae	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
TLS3_k127_6094787_21	710696.Intca_2225	1.2e-127	422.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4FEB5@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS3_k127_6121524_4	1193181.BN10_720012	4.001e-37	141.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4FHIT@85021|Intrasporangiaceae	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
TLS3_k127_6121524_1	710696.Intca_0193	5.619e-110	363.0	COG3391@1|root,COG3391@2|Bacteria,2I3GE@201174|Actinobacteria,4FFTN@85021|Intrasporangiaceae	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6121524_3	1448389.BAVQ01000025_gene1237	1.135e-64	226.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
TLS3_k127_6121524_0	1108045.GORHZ_247_00460	0.0	1031.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4GFNX@85026|Gordoniaceae	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_6121524_2	994479.GL877879_gene4567	2.975e-82	304.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DXHU@85010|Pseudonocardiales	201174|Actinobacteria	C	carbon monoxide dehydrogenase	cutM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
TLS3_k127_6149415_3	710696.Intca_1244	2.977e-106	345.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4FEHJ@85021|Intrasporangiaceae	201174|Actinobacteria	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_6149415_7	471852.Tcur_4131	2.651e-10	66.0	2DSSU@1|root,33HAR@2|Bacteria,2GWP2@201174|Actinobacteria,4EKXP@85012|Streptosporangiales	201174|Actinobacteria	S	Acyl-CoA carboxylase epsilon subunit	-	-	-	-	-	-	-	-	-	-	-	-	ACC_epsilon
TLS3_k127_6149415_1	1122998.AUHZ01000010_gene1557	2.119e-111	377.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4DPAD@85009|Propionibacteriales	201174|Actinobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
TLS3_k127_6149415_0	1032480.MLP_48880	1.626e-145	481.0	COG0318@1|root,COG0318@2|Bacteria,2HFFB@201174|Actinobacteria,4DUVT@85009|Propionibacteriales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
TLS3_k127_6149415_6	1032480.MLP_48910	1.275e-16	87.0	COG0736@1|root,COG0736@2|Bacteria,2GZK2@201174|Actinobacteria,4DW1H@85009|Propionibacteriales	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	-	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
TLS3_k127_6149415_4	1032480.MLP_48890	1.62e-69	247.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,Lipase_GDSL_2
TLS3_k127_6149415_5	479431.Namu_4495	5.133e-24	104.0	COG0236@1|root,COG0236@2|Bacteria,2GRZA@201174|Actinobacteria	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6149415_2	1032480.MLP_48850	4.553e-111	368.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4DQH7@85009|Propionibacteriales	201174|Actinobacteria	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
TLS3_k127_6179068_10	1121926.AXWO01000015_gene4318	1.373e-06	61.0	2CD9P@1|root,345NP@2|Bacteria,2H7WE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6179068_5	1385518.N798_09360	1.129e-98	366.0	COG2319@1|root,COG3629@1|root,COG2319@2|Bacteria,COG3629@2|Bacteria,2I3CQ@201174|Actinobacteria,4FK1F@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
TLS3_k127_6179068_0	313589.JNB_13293	4.014e-233	743.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4FFVB@85021|Intrasporangiaceae	201174|Actinobacteria	G	alpha-glucosidase	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
TLS3_k127_6179068_1	1120950.KB892744_gene2775	1.395e-199	630.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4DP01@85009|Propionibacteriales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_6179068_3	358823.DF19_24330	1.04e-138	449.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria	201174|Actinobacteria	K	lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS3_k127_6179068_2	479431.Namu_0584	2.404e-172	544.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4ES0F@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase LigD	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
TLS3_k127_6179068_6	477641.MODMU_1573	1.243e-62	219.0	COG0454@1|root,COG0456@2|Bacteria,2HUG3@201174|Actinobacteria,4EWZV@85013|Frankiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
TLS3_k127_6179068_4	390989.JOEG01000004_gene3992	6.1e-107	355.0	COG3173@1|root,COG3173@2|Bacteria,2GKUU@201174|Actinobacteria,4DACV@85008|Micromonosporales	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
TLS3_k127_6179068_9	1121272.KB903261_gene5953	1.453e-15	82.0	COG2020@1|root,COG2020@2|Bacteria,2GTDR@201174|Actinobacteria,4DM6V@85008|Micromonosporales	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
TLS3_k127_6179068_8	1121946.AUAX01000011_gene4003	5.008e-39	150.0	COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,4DM35@85008|Micromonosporales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6179068_7	1032480.MLP_34390	1.013e-57	205.0	COG0563@1|root,COG0563@2|Bacteria,2I45A@201174|Actinobacteria,4DSTH@85009|Propionibacteriales	201174|Actinobacteria	F	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,SKI
TLS3_k127_621937_6	367299.JOEE01000001_gene1814	3.767e-97	325.0	COG2761@1|root,COG2761@2|Bacteria,2GNBC@201174|Actinobacteria,4FF6U@85021|Intrasporangiaceae	201174|Actinobacteria	Q	isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
TLS3_k127_621937_10	1385520.N802_03910	2.68e-07	64.0	COG3631@1|root,COG3631@2|Bacteria,2GVR7@201174|Actinobacteria,4FJRE@85021|Intrasporangiaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
TLS3_k127_621937_3	685727.REQ_10460	5.331e-216	705.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FVP9@85025|Nocardiaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 3 family	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS3_k127_621937_1	367299.JOEE01000001_gene1817	3.623e-247	791.0	COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,4FEJB@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
TLS3_k127_621937_7	1172188.KB911831_gene3987	8.198e-94	326.0	COG0204@1|root,COG0204@2|Bacteria,2GQVG@201174|Actinobacteria,4FFRT@85021|Intrasporangiaceae	201174|Actinobacteria	I	1-acyl-sn-glycerol-3-phosphate acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_621937_9	1448389.BAVQ01000006_gene3190	2.628e-13	81.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	HMA
TLS3_k127_621937_5	1380370.JIBA01000006_gene3392	5.67e-98	324.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4FFJ4@85021|Intrasporangiaceae	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
TLS3_k127_621937_8	1385521.N803_09730	4.394e-71	247.0	299JI@1|root,2ZWN1@2|Bacteria,2GMZP@201174|Actinobacteria,4FGEG@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF5063)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5063
TLS3_k127_621937_2	1193181.BN10_1000003	3.459e-223	707.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4FEDQ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the aspartokinase family	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
TLS3_k127_621937_4	367299.JOEE01000001_gene1825	1.057e-146	473.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4FF89@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS3_k127_621937_0	367299.JOEE01000006_gene870	0.0	1386.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,4FEPE@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_623508_11	397278.JOJN01000002_gene202	2.676e-15	83.0	COG1610@1|root,COG1610@2|Bacteria,2GQVP@201174|Actinobacteria,4DVXX@85009|Propionibacteriales	201174|Actinobacteria	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
TLS3_k127_623508_3	1193181.BN10_920029	4.145e-115	388.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4FFAS@85021|Intrasporangiaceae	201174|Actinobacteria	FP	exopolyphosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
TLS3_k127_623508_6	1385520.N802_15565	4.166e-76	261.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4FGC6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
TLS3_k127_623508_9	1385518.N798_11670	2.052e-24	112.0	COG2919@1|root,COG2919@2|Bacteria,2GQH7@201174|Actinobacteria,4FHRY@85021|Intrasporangiaceae	201174|Actinobacteria	D	Septation ring formation regulator EzrA	divIC	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
TLS3_k127_623508_1	1121017.AUFG01000013_gene1894	4.659e-246	763.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4FE8B@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
TLS3_k127_623508_2	1385518.N798_11685	1.791e-124	421.0	COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,4FEJH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
TLS3_k127_623508_8	367299.JOEE01000007_gene180	1.274e-49	190.0	COG0524@1|root,COG1522@1|root,COG0524@2|Bacteria,COG1522@2|Bacteria,2HX6U@201174|Actinobacteria,4FF9C@85021|Intrasporangiaceae	201174|Actinobacteria	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,PfkB
TLS3_k127_623508_4	367299.JOEE01000007_gene182	1.172e-109	366.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4FF48@85021|Intrasporangiaceae	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
TLS3_k127_623508_10	1385518.N798_11720	1.793e-17	89.0	COG0760@1|root,COG0760@2|Bacteria,2IRRB@201174|Actinobacteria,4FHAX@85021|Intrasporangiaceae	201174|Actinobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_623508_7	1454010.JEOE01000005_gene1680	4.706e-52	189.0	COG4898@1|root,COG4898@2|Bacteria,2IKPX@201174|Actinobacteria,4F2IX@85016|Cellulomonadaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2200)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2200
TLS3_k127_623508_0	1385520.N802_15505	0.0	1732.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4FF0B@85021|Intrasporangiaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
TLS3_k127_623508_5	1385520.N802_15500	4.307e-91	303.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4FE5Y@85021|Intrasporangiaceae	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
TLS3_k127_6369031_1	1193181.BN10_1060018	3.497e-189	595.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4FE3K@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
TLS3_k127_6369031_0	1193181.BN10_1060017	0.0	1275.0	COG0072@1|root,COG0072@2|Bacteria,2GMFD@201174|Actinobacteria,4FEZ5@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
TLS3_k127_6369031_8	1385520.N802_00065	6.553e-93	317.0	COG0300@1|root,COG0300@2|Bacteria,2IEDC@201174|Actinobacteria,4FGDN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_6369031_6	1380347.JNII01000008_gene4423	5.388e-125	411.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4ESJ9@85013|Frankiales	201174|Actinobacteria	GM	epimerase dehydratase	galE4	-	-	-	-	-	-	-	-	-	-	-	Epimerase
TLS3_k127_6369031_3	1386089.N865_11220	1.854e-162	517.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,4FEVG@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
TLS3_k127_6369031_9	367299.JOEE01000010_gene3291	5.438e-30	135.0	COG3603@1|root,COG3603@2|Bacteria,2GQH9@201174|Actinobacteria,4FHHQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	ACT domain	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
TLS3_k127_6369031_2	1193181.BN10_1060014	1.616e-178	566.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4FFF4@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
TLS3_k127_6369031_5	367299.JOEE01000010_gene3289	1.065e-142	460.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4FFJU@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
TLS3_k127_6369031_4	1385518.N798_02500	3.339e-155	518.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,4FE84@85021|Intrasporangiaceae	201174|Actinobacteria	E	acetylornithine aminotransferase	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_6369031_7	1193181.BN10_1060010	2.121e-124	402.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4FG3W@85021|Intrasporangiaceae	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
TLS3_k127_6372666_11	211114.JOEF01000019_gene583	1.524e-19	87.0	COG1247@1|root,COG1247@2|Bacteria,2I49I@201174|Actinobacteria,4E02X@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
TLS3_k127_6372666_2	1123024.AUII01000010_gene787	2.734e-161	533.0	COG0840@1|root,COG4251@1|root,COG0840@2|Bacteria,COG4251@2|Bacteria,2GK6E@201174|Actinobacteria,4DX42@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	cvnA6	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
TLS3_k127_6372666_9	1123024.AUII01000010_gene786	4.773e-49	179.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria,4E2K7@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Roadblock LC7	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
TLS3_k127_6372666_10	2074.JNYD01000012_gene439	5.637e-33	132.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DUF3489,DUF742
TLS3_k127_6372666_7	1123024.AUII01000010_gene784	5.614e-82	282.0	COG2229@1|root,COG2229@2|Bacteria,2GM4V@201174|Actinobacteria	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
TLS3_k127_6372666_1	1440053.JOEI01000019_gene728	3.634e-188	619.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
TLS3_k127_6372666_5	1123024.AUII01000006_gene4591	2.464e-97	328.0	COG0583@1|root,COG0583@2|Bacteria,2I8WJ@201174|Actinobacteria,4E184@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_6372666_3	1120948.KB903221_gene468	7.634e-125	408.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4DXFH@85010|Pseudonocardiales	201174|Actinobacteria	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
TLS3_k127_6372666_8	35754.JNYJ01000054_gene9712	1.062e-76	260.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4DCVY@85008|Micromonosporales	201174|Actinobacteria	C	[2Fe-2S] binding domain	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
TLS3_k127_6372666_0	1120948.KB903221_gene466	0.0	1416.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E1RG@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, large subunit	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_6372666_6	35754.JNYJ01000054_gene9714	1.394e-88	305.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2IA9U@201174|Actinobacteria,4DDBA@85008|Micromonosporales	201174|Actinobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
TLS3_k127_6372666_4	1123024.AUII01000006_gene4586	2.191e-121	402.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4E87H@85010|Pseudonocardiales	201174|Actinobacteria	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS3_k127_6386396_5	1385519.N801_12460	6.339e-69	244.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4FGCE@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative single-stranded nucleic acids-binding domain	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
TLS3_k127_6386396_3	313589.JNB_13428	3.002e-140	454.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4FFAN@85021|Intrasporangiaceae	201174|Actinobacteria	U	Preprotein translocase subunit YidC	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
TLS3_k127_6386396_6	367299.JOEE01000002_gene2639	4.575e-37	144.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,4FHQY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
TLS3_k127_6386396_7	1385520.N802_04825	2.487e-33	133.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4FHJI@85021|Intrasporangiaceae	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
TLS3_k127_6386396_8	313589.JNB_13413	1.153e-14	79.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4FHTP@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
TLS3_k127_6386396_0	1385520.N802_04815	2.659e-212	673.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4FFMY@85021|Intrasporangiaceae	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
TLS3_k127_6386396_1	1385521.N803_13640	8.199e-193	606.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4FG4P@85021|Intrasporangiaceae	201174|Actinobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
TLS3_k127_6386396_2	1385518.N798_03930	4.498e-173	550.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4FG04@85021|Intrasporangiaceae	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
TLS3_k127_6386396_4	1380370.JIBA01000010_gene2483	1.241e-106	350.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4FEU1@85021|Intrasporangiaceae	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
TLS3_k127_6458057_1	1385518.N798_14380	1.369e-114	375.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4FEC0@85021|Intrasporangiaceae	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
TLS3_k127_6458057_0	1380370.JIBA01000017_gene2855	1.188e-145	469.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4FEZH@85021|Intrasporangiaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
TLS3_k127_6458057_2	1122622.ATWJ01000009_gene3294	5.138e-51	188.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4FE62@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
TLS3_k127_6534351_2	1210046.B277_02301	3.231e-89	308.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4FFEI@85021|Intrasporangiaceae	201174|Actinobacteria	L	DEAD DEAH box helicase	rhlE_2	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
TLS3_k127_6534351_7	1032480.MLP_35520	1.75e-33	138.0	2E091@1|root,32VWN@2|Bacteria,2ITBF@201174|Actinobacteria,4DUN1@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6534351_1	1032480.MLP_35540	3.744e-181	589.0	COG4585@1|root,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4DTI1@85009|Propionibacteriales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS3_k127_6534351_4	1463856.JOHY01000063_gene6339	4.846e-65	235.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_6534351_8	1385518.N798_16795	9.852e-25	112.0	COG5652@1|root,COG5652@2|Bacteria,2HNF3@201174|Actinobacteria,4FHWW@85021|Intrasporangiaceae	201174|Actinobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6534351_6	367299.JOEE01000003_gene2890	2.1e-36	145.0	COG2968@1|root,COG2968@2|Bacteria,2HU9D@201174|Actinobacteria,4FF6Z@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF541)	-	-	-	-	-	-	-	-	-	-	-	-	SIMPL
TLS3_k127_6534351_3	1385521.N803_01800	2.744e-81	278.0	COG1246@1|root,COG1246@2|Bacteria,2ICRQ@201174|Actinobacteria,4FEC7@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV
TLS3_k127_6534351_0	1193181.BN10_820042	0.0	1313.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4FFQQ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
TLS3_k127_6534351_5	1385521.N803_01805	7.921e-53	193.0	COG0671@1|root,COG0671@2|Bacteria,2HGFY@201174|Actinobacteria,4FFCR@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
TLS3_k127_6552642_11	1193181.BN10_680082	6.772e-78	267.0	COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,4FIWM@85021|Intrasporangiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_6552642_7	1193181.BN10_1600010	7.008e-109	363.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4FF90@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
TLS3_k127_6552642_15	765912.Thimo_0178	1.577e-25	111.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1WYXG@135613|Chromatiales	135613|Chromatiales	P	Divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
TLS3_k127_6552642_14	1385519.N801_15150	6.989e-51	188.0	COG2267@1|root,COG2267@2|Bacteria,2I3AW@201174|Actinobacteria,4FH0C@85021|Intrasporangiaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4,Peptidase_S9
TLS3_k127_6552642_2	1385520.N802_02945	2.905e-180	582.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FITR@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the amidase family	amiC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
TLS3_k127_6552642_0	367299.JOEE01000001_gene1627	0.0	1090.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2H2H9@201174|Actinobacteria,4FEGT@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
TLS3_k127_6552642_6	1121017.AUFG01000019_gene2378	1.108e-133	430.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4FF7S@85021|Intrasporangiaceae	201174|Actinobacteria	C	tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
TLS3_k127_6552642_10	110319.CF8_0280	2.086e-88	301.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
TLS3_k127_6552642_9	1122622.ATWJ01000008_gene2777	3.588e-93	308.0	COG3467@1|root,COG3467@2|Bacteria,2HGVK@201174|Actinobacteria,4FGIE@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
TLS3_k127_6552642_8	290397.Adeh_0396	6.711e-98	350.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2YTWZ@29|Myxococcales	28221|Deltaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS3_k127_6552642_3	1089455.MOPEL_132_00070	4.533e-156	522.0	COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,4F6DZ@85018|Dermatophilaceae	201174|Actinobacteria	C	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
TLS3_k127_6552642_12	1385519.N801_19835	1.888e-72	265.0	COG5340@1|root,COG5340@2|Bacteria,2IMGD@201174|Actinobacteria,4FH66@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
TLS3_k127_6552642_5	1184607.AUCHE_09_00450	7.825e-148	481.0	COG1085@1|root,COG1085@2|Bacteria,2IA73@201174|Actinobacteria,4F63M@85018|Dermatophilaceae	201174|Actinobacteria	C	Domain of unknown function (DUF4921)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4921
TLS3_k127_6552642_1	2045.KR76_19095	2.694e-181	575.0	COG3853@1|root,COG3853@2|Bacteria,2GNWN@201174|Actinobacteria,4DPZG@85009|Propionibacteriales	201174|Actinobacteria	P	Toxic anion resistance protein (TelA)	-	-	-	-	-	-	-	-	-	-	-	-	TelA
TLS3_k127_6552642_13	935866.JAER01000003_gene1172	4.931e-61	215.0	2BDZ4@1|root,327PI@2|Bacteria,2IN10@201174|Actinobacteria,4DUTE@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6552642_4	313589.JNB_13013	4.763e-156	514.0	COG0464@1|root,COG0464@2|Bacteria,2GJWA@201174|Actinobacteria,4FEFU@85021|Intrasporangiaceae	201174|Actinobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
TLS3_k127_6613479_14	1122622.ATWJ01000009_gene3145	8.03e-07	51.0	COG1432@1|root,COG1432@2|Bacteria,2HB6H@201174|Actinobacteria,4FFNZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
TLS3_k127_6613479_8	1184607.AUCHE_16_00330	4.404e-51	198.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria,4F7X4@85018|Dermatophilaceae	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.2.1.8,3.5.1.104	ko:K01181,ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
TLS3_k127_6613479_12	1349820.M707_18110	2.529e-12	79.0	COG0739@1|root,COG3391@1|root,COG0739@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PD40,VCBS
TLS3_k127_6613479_2	313589.JNB_16958	6.444e-213	677.0	COG4346@1|root,COG4346@2|Bacteria,2GITT@201174|Actinobacteria,4FEHH@85021|Intrasporangiaceae	201174|Actinobacteria	O	membrane	pmt	GO:0000030,GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_2,PMT_4TMC
TLS3_k127_6613479_4	1386089.N865_09815	1.86e-119	389.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4FF19@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
TLS3_k127_6613479_6	1193181.BN10_630020	8.915e-87	292.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria,4FFTC@85021|Intrasporangiaceae	201174|Actinobacteria	S	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
TLS3_k127_6613479_0	1385519.N801_02975	0.0	1205.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4FFQS@85021|Intrasporangiaceae	201174|Actinobacteria	C	SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556	sdhA	-	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
TLS3_k127_6613479_3	1385518.N798_11855	4.839e-144	460.0	COG0479@1|root,COG0479@2|Bacteria,2GJPS@201174|Actinobacteria,4FEDH@85021|Intrasporangiaceae	201174|Actinobacteria	C	succinate dehydrogenase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
TLS3_k127_6613479_5	313589.JNB_17013	1.773e-114	375.0	COG1266@1|root,COG1266@2|Bacteria,2GK11@201174|Actinobacteria,4FFNK@85021|Intrasporangiaceae	201174|Actinobacteria	S	protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
TLS3_k127_6613479_11	1193181.BN10_1560001	6.905e-14	81.0	COG2801@1|root,COG2801@2|Bacteria,2I3ET@201174|Actinobacteria,4FFIX@85021|Intrasporangiaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS3_k127_6613479_13	1123251.ATWM01000009_gene2797	7.473e-12	67.0	COG2801@1|root,COG2801@2|Bacteria,2I3ET@201174|Actinobacteria,4FFIX@85021|Intrasporangiaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS3_k127_6613479_10	465515.Mlut_18330	3.398e-21	97.0	COG2801@1|root,COG2801@2|Bacteria,2I3ET@201174|Actinobacteria,1WBGS@1268|Micrococcaceae	201174|Actinobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
TLS3_k127_6613479_15	710696.Intca_3505	0.0007	43.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4FEXK@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
TLS3_k127_6613479_7	1193181.BN10_630029	5.135e-83	280.0	2DM5T@1|root,31U0Y@2|Bacteria,2I89A@201174|Actinobacteria,4FFV7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
TLS3_k127_6613479_1	367299.JOEE01000007_gene220	1.009e-239	746.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4FED6@85021|Intrasporangiaceae	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
TLS3_k127_6613479_9	367299.JOEE01000007_gene220	2.474e-34	132.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4FED6@85021|Intrasporangiaceae	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
TLS3_k127_6631466_1	1385521.N803_00945	8.627e-131	419.0	COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria,4FFQE@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
TLS3_k127_6631466_5	1385521.N803_00950	4.31e-59	209.0	COG0262@1|root,COG0262@2|Bacteria,2IM1S@201174|Actinobacteria,4FGNT@85021|Intrasporangiaceae	201174|Actinobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1,NUDIX
TLS3_k127_6631466_7	1122622.ATWJ01000009_gene3086	1.35e-48	179.0	2BP0K@1|root,32HQY@2|Bacteria,2H5KW@201174|Actinobacteria,4FJ33@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6631466_6	1380386.JIAW01000003_gene898	8.993e-52	195.0	2DN35@1|root,32V90@2|Bacteria,2GSBX@201174|Actinobacteria,2365G@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6631466_4	318424.EU78_23950	1.475e-69	242.0	COG1595@1|root,COG1595@2|Bacteria,2IRIQ@201174|Actinobacteria,236Y6@1762|Mycobacteriaceae	201174|Actinobacteria	K	SatD family (SatD)	-	-	-	-	-	-	-	-	-	-	-	-	SatD
TLS3_k127_6631466_0	1386089.N865_17380	6.076e-137	452.0	COG1018@1|root,COG1018@2|Bacteria,2GKGS@201174|Actinobacteria,4FF97@85021|Intrasporangiaceae	201174|Actinobacteria	C	phenylacetic acid degradation	paaE	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,FA_desaturase,Fer2,NAD_binding_1
TLS3_k127_6631466_8	1386089.N865_17385	2.385e-46	186.0	COG2151@1|root,COG2151@2|Bacteria,2II4H@201174|Actinobacteria,4FGVA@85021|Intrasporangiaceae	201174|Actinobacteria	S	Iron-sulfur cluster assembly protein	paaJ	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
TLS3_k127_6631466_3	1184609.KILIM_004_00520	2.136e-92	318.0	COG3396@1|root,COG3396@2|Bacteria,2GJIU@201174|Actinobacteria,4F7T7@85018|Dermatophilaceae	201174|Actinobacteria	S	Phenylacetic acid catabolic protein	paaI	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS3_k127_6631466_2	1121385.AQXW01000004_gene1533	1.262e-122	394.0	COG3396@1|root,COG3396@2|Bacteria,2GMQ3@201174|Actinobacteria,1ZWFW@145357|Dermacoccaceae	201174|Actinobacteria	S	Phenylacetic acid catabolic protein	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
TLS3_k127_6828003_1	1206737.BAGF01000066_gene4183	7.348e-189	629.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4FVD0@85025|Nocardiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
TLS3_k127_6828003_4	471857.Svir_18250	1.655e-71	243.0	COG3795@1|root,COG3795@2|Bacteria,2IHYC@201174|Actinobacteria,4E3IE@85010|Pseudonocardiales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
TLS3_k127_6828003_7	1120948.KB903246_gene3420	7.645e-35	148.0	2EI5Z@1|root,33BXC@2|Bacteria	2|Bacteria	S	Polysaccharide lyase	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4,Polysacc_lyase
TLS3_k127_6828003_0	2074.JNYD01000046_gene7295	6.272e-212	682.0	COG0642@1|root,COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria,4DZ1T@85010|Pseudonocardiales	201174|Actinobacteria	KT	Serine phosphatase RsbU, regulator of sigma subunit	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
TLS3_k127_6828003_2	1463920.JOGB01000037_gene1029	8.087e-158	505.0	COG0426@1|root,COG0426@2|Bacteria,2GJT6@201174|Actinobacteria	201174|Actinobacteria	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
TLS3_k127_6828003_3	1380390.JIAT01000013_gene124	1.405e-128	423.0	COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
TLS3_k127_6828003_6	1463917.JODC01000016_gene2314	1.001e-41	156.0	2BQN0@1|root,32JI7@2|Bacteria,2H9EZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6828003_8	2074.JNYD01000004_gene4650	3.562e-06	53.0	COG0582@1|root,COG0582@2|Bacteria,2I9QS@201174|Actinobacteria,4E68K@85010|Pseudonocardiales	201174|Actinobacteria	KL	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
TLS3_k127_6828003_9	58344.JOEL01000007_gene4484	0.0002177	44.0	COG0582@1|root,COG0582@2|Bacteria,2IHIW@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
TLS3_k127_6828003_5	67257.JODR01000043_gene411	1.666e-43	162.0	2E3RQ@1|root,32YPC@2|Bacteria,2IKMN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6908875_7	1122918.KB907247_gene4691	1.036e-07	53.0	2EIAV@1|root,33C29@2|Bacteria,1VMAE@1239|Firmicutes,4HRG9@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6908875_0	1385520.N802_02650	0.0	1323.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4FE8P@85021|Intrasporangiaceae	201174|Actinobacteria	S	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
TLS3_k127_6908875_3	313589.JNB_07319	2.961e-68	237.0	2DA1Q@1|root,32TUF@2|Bacteria,2GKR3@201174|Actinobacteria,4FFPB@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6908875_2	1385519.N801_07990	1.043e-83	294.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4FFGH@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the peptidase S16 family	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
TLS3_k127_6908875_5	2045.KR76_09355	2.804e-39	168.0	COG0314@1|root,COG0314@2|Bacteria,2IQ9F@201174|Actinobacteria,4DR9R@85009|Propionibacteriales	201174|Actinobacteria	H	MoaE protein	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
TLS3_k127_6908875_1	1385518.N798_08875	1.294e-132	442.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria,4FFHM@85021|Intrasporangiaceae	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
TLS3_k127_6908875_4	1121385.AQXW01000004_gene1828	3.574e-48	181.0	COG1051@1|root,COG1051@2|Bacteria,2I2SX@201174|Actinobacteria	201174|Actinobacteria	F	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
TLS3_k127_6908875_6	1380370.JIBA01000015_gene8	8.737e-23	107.0	2E479@1|root,32Z35@2|Bacteria,2GQXY@201174|Actinobacteria,4FHV1@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_6951109_6	1121385.AQXW01000004_gene2829	1.035e-71	246.0	COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria,1ZWNP@145357|Dermacoccaceae	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
TLS3_k127_6951109_1	188626.HMPREF0321_0955	8.303e-184	586.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,1ZVKF@145357|Dermacoccaceae	201174|Actinobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
TLS3_k127_6951109_3	1385518.N798_16715	5.114e-109	357.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4FF75@85021|Intrasporangiaceae	201174|Actinobacteria	D	Cell division	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
TLS3_k127_6951109_2	1385520.N802_01950	5.167e-124	406.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4FE39@85021|Intrasporangiaceae	201174|Actinobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
TLS3_k127_6951109_4	1385518.N798_16725	1.45e-89	313.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4FGM1@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidase family M23	pdc2	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
TLS3_k127_6951109_5	1385521.N803_01850	7.392e-73	251.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4FEJ8@85021|Intrasporangiaceae	201174|Actinobacteria	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
TLS3_k127_6951109_0	1385518.N798_16735	6.684e-206	659.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,4FEME@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
TLS3_k127_7121377_5	1121385.AQXW01000003_gene610	2.224e-28	116.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,1ZVMJ@145357|Dermacoccaceae	201174|Actinobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS3_k127_7121377_2	1122622.ATWJ01000007_gene1912	2.069e-261	819.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4FEHR@85021|Intrasporangiaceae	201174|Actinobacteria	I	AMP-dependent synthetase	fadD11_1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_7121377_0	1386089.N865_18010	0.0	1219.0	COG1032@1|root,COG1032@2|Bacteria,2GJY1@201174|Actinobacteria,4FFMS@85021|Intrasporangiaceae	201174|Actinobacteria	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
TLS3_k127_7121377_3	367299.JOEE01000004_gene1264	1.009e-234	732.0	COG0001@1|root,COG0001@2|Bacteria,2HBVS@201174|Actinobacteria,4FF6H@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_7121377_6	298654.FraEuI1c_7182	1.835e-09	71.0	COG2304@1|root,COG2304@2|Bacteria,2GNSN@201174|Actinobacteria,4ESM2@85013|Frankiales	201174|Actinobacteria	P	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA,VWA_2
TLS3_k127_7121377_4	1385520.N802_10120	3.55e-96	323.0	COG5011@1|root,COG5011@2|Bacteria,2GIS7@201174|Actinobacteria,4FFAZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Radical SAM protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
TLS3_k127_7121377_1	367299.JOEE01000004_gene1266	1.211e-270	863.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4FERM@85021|Intrasporangiaceae	201174|Actinobacteria	J	Ribonuclease E/G family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
TLS3_k127_7137743_12	452652.KSE_69040	2.77e-24	102.0	COG1090@1|root,COG1090@2|Bacteria,2GU34@201174|Actinobacteria,2M17T@2063|Kitasatospora	201174|Actinobacteria	S	overlaps another CDS with the same product name	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS3_k127_7137743_5	1157640.AQWO01000013_gene1477	2.077e-82	278.0	COG1090@1|root,COG1090@2|Bacteria,2GU34@201174|Actinobacteria	201174|Actinobacteria	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
TLS3_k127_7137743_6	479433.Caci_8900	2.266e-67	246.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_7137743_9	1120934.KB894458_gene1455	7.224e-38	156.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4E15I@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
TLS3_k127_7137743_13	1172188.KB911820_gene2194	5.049e-18	91.0	2EQUW@1|root,33IEN@2|Bacteria,2GQQ7@201174|Actinobacteria,4FJK9@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7137743_11	1254432.SCE1572_26520	8.604e-28	116.0	COG4634@1|root,COG4634@2|Bacteria,1RH7A@1224|Proteobacteria,42Y3E@68525|delta/epsilon subdivisions,2WSPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
TLS3_k127_7137743_14	1048339.KB913029_gene4883	2.58e-17	84.0	COG2442@1|root,COG2442@2|Bacteria,2GQXF@201174|Actinobacteria,4EWUT@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
TLS3_k127_7137743_8	1184607.AUCHE_08_04290	3.47e-41	158.0	COG4584@1|root,COG4584@2|Bacteria,2HGYS@201174|Actinobacteria,4F84H@85018|Dermatophilaceae	201174|Actinobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7137743_3	1043205.AFYF01000029_gene200	6.958e-147	475.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4FG2P@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	intA	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
TLS3_k127_7137743_4	1385519.N801_19635	8.944e-125	432.0	COG2966@1|root,COG2966@2|Bacteria,2GJMC@201174|Actinobacteria,4FF3I@85021|Intrasporangiaceae	201174|Actinobacteria	S	Threonine/Serine exporter, ThrE	-	-	-	-	-	-	-	-	-	-	-	-	ThrE,ThrE_2
TLS3_k127_7137743_2	1385521.N803_03910	3.814e-169	553.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4FE5H@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
TLS3_k127_7137743_7	1385521.N803_03900	6.109e-55	196.0	COG2905@1|root,COG2905@2|Bacteria,2I3M3@201174|Actinobacteria,4FJZR@85021|Intrasporangiaceae	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
TLS3_k127_7137743_1	1385521.N803_03895	1.176e-198	623.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4FF7N@85021|Intrasporangiaceae	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	msiK	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
TLS3_k127_7137743_0	367299.JOEE01000006_gene715	2.79e-218	682.0	COG3642@1|root,COG3642@2|Bacteria,2GIX0@201174|Actinobacteria,4FE9W@85021|Intrasporangiaceae	201174|Actinobacteria	T	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,Kdo
TLS3_k127_7137743_10	1385521.N803_03880	5.751e-30	123.0	2E37T@1|root,32Y7G@2|Bacteria,2HKU0@201174|Actinobacteria,4FHMR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
TLS3_k127_7143785_5	1385521.N803_05910	7.639e-09	64.0	2CA8H@1|root,2ZUAJ@2|Bacteria,2HK50@201174|Actinobacteria,4FI5G@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7143785_2	1048339.KB913029_gene1793	4.64e-35	136.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4ET19@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
TLS3_k127_7143785_1	1193181.BN10_230012	1.029e-306	955.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4FG7V@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
TLS3_k127_7143785_0	1043205.AFYF01000034_gene128	0.0	1268.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,2GKXQ@201174|Actinobacteria,4FFWS@85021|Intrasporangiaceae	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
TLS3_k127_7143785_3	685035.ADAE01000018_gene393	1.455e-34	138.0	COG5470@1|root,COG5470@2|Bacteria,1MWI7@1224|Proteobacteria,2U0S6@28211|Alphaproteobacteria,2K499@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
TLS3_k127_7177499_0	1385519.N801_02740	0.0	1067.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4FFR9@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS3_k127_7177499_10	1385519.N801_02745	1.391e-102	340.0	COG1075@1|root,COG1075@2|Bacteria,2GJGC@201174|Actinobacteria,4FJ9E@85021|Intrasporangiaceae	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
TLS3_k127_7177499_4	1193181.BN10_900043	7.837e-190	605.0	COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,4FIKH@85021|Intrasporangiaceae	201174|Actinobacteria	I	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
TLS3_k127_7177499_13	1386089.N865_17015	1.686e-92	307.0	COG3145@1|root,COG3145@2|Bacteria,2GNBD@201174|Actinobacteria,4FFUM@85021|Intrasporangiaceae	201174|Actinobacteria	L	Alkylated DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
TLS3_k127_7177499_7	1385520.N802_00570	2.517e-119	390.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4FE7P@85021|Intrasporangiaceae	201174|Actinobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
TLS3_k127_7177499_5	367299.JOEE01000009_gene317	1.684e-146	467.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4FF2R@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110	-	R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
TLS3_k127_7177499_9	1184607.AUCHE_02_00210	1.381e-102	347.0	COG0701@1|root,COG0701@2|Bacteria,2GJQ0@201174|Actinobacteria	201174|Actinobacteria	P	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
TLS3_k127_7177499_16	1449346.JQMO01000002_gene346	1.674e-37	155.0	COG3689@1|root,COG3689@2|Bacteria,2GZEU@201174|Actinobacteria	201174|Actinobacteria	S	TIGRFAM TIGR03943 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1980
TLS3_k127_7177499_14	1122622.ATWJ01000007_gene1961	3.611e-55	198.0	COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,4FGX7@85021|Intrasporangiaceae	201174|Actinobacteria	P	Belongs to the Fur family	furB	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS3_k127_7177499_6	1385520.N802_00555	2.037e-119	406.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,4FFBH@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
TLS3_k127_7177499_11	1385518.N798_02950	1.205e-99	332.0	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria,4FIEC@85021|Intrasporangiaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	mntB	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
TLS3_k127_7177499_8	367299.JOEE01000009_gene321	1.544e-104	349.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4FE83@85021|Intrasporangiaceae	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	scbA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
TLS3_k127_7177499_17	1385519.N801_02805	1.655e-25	108.0	2C98I@1|root,33EGA@2|Bacteria,2GXMN@201174|Actinobacteria,4FHZR@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7177499_12	367299.JOEE01000009_gene327	4.301e-98	327.0	COG2897@1|root,COG2897@2|Bacteria,2GMDR@201174|Actinobacteria,4FEGD@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
TLS3_k127_7177499_15	1121385.AQXW01000001_gene734	7.299e-46	172.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,1ZWK8@145357|Dermacoccaceae	201174|Actinobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
TLS3_k127_7177499_2	1172188.KB911821_gene1191	6.271e-195	631.0	COG0042@1|root,COG0042@2|Bacteria,2GJ8I@201174|Actinobacteria,4FFGK@85021|Intrasporangiaceae	201174|Actinobacteria	J	tRNA-dihydrouridine synthase	dus	GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Dus
TLS3_k127_7177499_3	1385521.N803_00445	1.804e-190	618.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4FE8F@85021|Intrasporangiaceae	201174|Actinobacteria	F	Deoxyguanosinetriphosphate triphosphohydrolase-like protein	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
TLS3_k127_7177499_1	710696.Intca_2113	3.718e-250	787.0	COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4FE70@85021|Intrasporangiaceae	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
TLS3_k127_7177499_19	1385518.N798_02850	4.958e-07	55.0	COG0776@1|root,COG0776@2|Bacteria,2IQFT@201174|Actinobacteria,4FHGB@85021|Intrasporangiaceae	201174|Actinobacteria	L	regulation of translation	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7188615_0	935839.JAGJ01000029_gene9	0.0	1877.0	COG2247@1|root,COG2931@1|root,COG2247@2|Bacteria,COG2931@2|Bacteria,2HFCX@201174|Actinobacteria,4F5WU@85017|Promicromonosporaceae	201174|Actinobacteria	Q	cell wall binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7188615_1	1122622.ATWJ01000015_gene609	7.904e-148	479.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4FEZM@85021|Intrasporangiaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_7188615_2	2002.JOEQ01000055_gene464	6.784e-117	392.0	COG3391@1|root,COG3391@2|Bacteria,2H8XQ@201174|Actinobacteria	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7188615_3	1121272.KB903249_gene1781	3.98e-84	293.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria,4DFGJ@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_7188615_5	1122622.ATWJ01000008_gene2811	1.074e-09	62.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,4FIPJ@85021|Intrasporangiaceae	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS3_k127_7188615_4	1122622.ATWJ01000008_gene2811	2.737e-24	105.0	COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,4FIPJ@85021|Intrasporangiaceae	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
TLS3_k127_7197935_6	1122622.ATWJ01000008_gene2981	0.0007031	47.0	COG2385@1|root,COG2931@1|root,COG2385@2|Bacteria,COG2931@2|Bacteria,2GKS7@201174|Actinobacteria,4FFUE@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind,Peptidase_M91
TLS3_k127_7197935_4	1043205.AFYF01000029_gene231	2.361e-54	194.0	COG4270@1|root,COG4270@2|Bacteria,2IKKP@201174|Actinobacteria,4FGX3@85021|Intrasporangiaceae	201174|Actinobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
TLS3_k127_7197935_3	593907.Celgi_0153	1.288e-60	213.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
TLS3_k127_7197935_1	1385518.N798_12040	4.498e-116	381.0	COG0406@1|root,COG0406@2|Bacteria,2GN7B@201174|Actinobacteria,4FGHF@85021|Intrasporangiaceae	201174|Actinobacteria	G	phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
TLS3_k127_7197935_2	1385519.N801_00445	2.139e-95	340.0	COG0063@1|root,COG0063@2|Bacteria,2IFVX@201174|Actinobacteria,4FGHG@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136	ko:K17758	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase
TLS3_k127_7197935_5	362242.MUL_5033	5.476e-19	98.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,2343K@1762|Mycobacteriaceae	201174|Actinobacteria	T	Universal stress protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_7197935_0	1122622.ATWJ01000012_gene919	1.023e-156	500.0	COG0667@1|root,COG0667@2|Bacteria,2GJBG@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
TLS3_k127_7201566_6	1193181.BN10_660002	2.444e-169	539.0	COG2733@1|root,COG2733@2|Bacteria,2GKGM@201174|Actinobacteria,4FFFE@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
TLS3_k127_7201566_35	1121017.AUFG01000028_gene586	6.039e-69	243.0	COG0676@1|root,COG0676@2|Bacteria,2IIUH@201174|Actinobacteria,4FGYP@85021|Intrasporangiaceae	201174|Actinobacteria	G	Aldose 1-epimerase	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
TLS3_k127_7201566_29	1385519.N801_05260	3.535e-99	332.0	COG3832@1|root,COG3832@2|Bacteria,2GY9A@201174|Actinobacteria	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7201566_24	1146883.BLASA_4538	1.197e-106	355.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria	201174|Actinobacteria	P	phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	HSP70,PBP_like,PBP_like_2
TLS3_k127_7201566_32	1906.SFRA_16855	1.409e-89	306.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS3_k127_7201566_28	469383.Cwoe_4494	3.683e-100	340.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4CQ28@84995|Rubrobacteria	84995|Rubrobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS3_k127_7201566_11	397278.JOJN01000006_gene1131	7.24e-137	439.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4DT2Q@85009|Propionibacteriales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS3_k127_7201566_55	1385519.N801_11295	0.000467	52.0	COG0745@1|root,COG0745@2|Bacteria,2IGPM@201174|Actinobacteria	201174|Actinobacteria	KT	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_7201566_52	593907.Celgi_2695	1.421e-19	102.0	COG0526@1|root,COG0526@2|Bacteria,2GUBI@201174|Actinobacteria	201174|Actinobacteria	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
TLS3_k127_7201566_7	350058.Mvan_5316	1.776e-156	504.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
TLS3_k127_7201566_49	644284.Arch_1551	1.255e-30	123.0	COG0640@1|root,COG0640@2|Bacteria,2GQU5@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS3_k127_7201566_26	1122138.AQUZ01000044_gene4502	4.662e-104	349.0	COG0701@1|root,COG0701@2|Bacteria,2HZBT@201174|Actinobacteria	201174|Actinobacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
TLS3_k127_7201566_48	1035308.AQYY01000002_gene646	3.584e-32	130.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
TLS3_k127_7201566_13	1449058.JQKT01000016_gene1992	5.753e-136	445.0	COG2017@1|root,COG2017@2|Bacteria,2GJ0H@201174|Actinobacteria,4FMHI@85023|Microbacteriaceae	201174|Actinobacteria	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
TLS3_k127_7201566_8	1449058.JQKT01000009_gene120	1.292e-153	495.0	COG1940@1|root,COG1940@2|Bacteria,2GJIE@201174|Actinobacteria,4FKFZ@85023|Microbacteriaceae	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,ROK
TLS3_k127_7201566_5	1449058.JQKT01000009_gene119	3.474e-170	546.0	COG1653@1|root,COG1653@2|Bacteria,2GP9H@201174|Actinobacteria,4FQWU@85023|Microbacteriaceae	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_7201566_23	1449058.JQKT01000009_gene118	1.345e-112	372.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4FMEC@85023|Microbacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
TLS3_k127_7201566_20	1449058.JQKT01000009_gene117	2.303e-121	402.0	COG0395@1|root,COG0395@2|Bacteria,2GNQW@201174|Actinobacteria,4FKPQ@85023|Microbacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10119,ko:K17243	ko02010,map02010	M00196,M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28,3.A.1.1.39	-	-	BPD_transp_1
TLS3_k127_7201566_1	996637.SGM_6395	0.0	1038.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	-	-	-	ko:K17641	-	-	-	-	ko00000	-	-	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
TLS3_k127_7201566_4	1449058.JQKT01000009_gene115	1.539e-177	562.0	COG1609@1|root,COG1609@2|Bacteria,2GJRG@201174|Actinobacteria,4FKXV@85023|Microbacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529,ko:K17640	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS3_k127_7201566_2	1449058.JQKT01000009_gene114	1.329e-240	745.0	COG2115@1|root,COG2115@2|Bacteria,2GJCA@201174|Actinobacteria,4FKGV@85023|Microbacteriaceae	201174|Actinobacteria	G	D-xylose metabolic process	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
TLS3_k127_7201566_3	1451261.AS96_08755	1.781e-213	669.0	COG1070@1|root,COG1070@2|Bacteria,2GJDZ@201174|Actinobacteria,4FKPT@85023|Microbacteriaceae	201174|Actinobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_7201566_47	1386089.N865_04825	5.174e-33	129.0	2EAZS@1|root,32VK9@2|Bacteria,2I73Y@201174|Actinobacteria,4FHIA@85021|Intrasporangiaceae	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
TLS3_k127_7201566_12	1385518.N798_05890	1.549e-136	446.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4FF5I@85021|Intrasporangiaceae	201174|Actinobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
TLS3_k127_7201566_36	1385518.N798_00625	6.99e-67	254.0	28MMU@1|root,2ZAXG@2|Bacteria,2HAD5@201174|Actinobacteria,4FE7N@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7201566_54	1121385.AQXW01000004_gene3181	6.53e-07	53.0	2DC7Y@1|root,2ZD7G@2|Bacteria,2H00P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7201566_14	1210046.B277_08954	2.214e-135	454.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4FF30@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
TLS3_k127_7201566_16	1184609.KILIM_028_00130	4.197e-130	437.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4F6T2@85018|Dermatophilaceae	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS3_k127_7201566_19	1184609.KILIM_028_00140	3.79e-125	409.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria,4F6Y1@85018|Dermatophilaceae	201174|Actinobacteria	U	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
TLS3_k127_7201566_21	1146883.BLASA_4539	1.321e-118	392.0	COG0226@1|root,COG0226@2|Bacteria,2GJXD@201174|Actinobacteria,4ERED@85013|Frankiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
TLS3_k127_7201566_30	710696.Intca_2952	3.791e-98	333.0	COG0494@1|root,COG2062@1|root,COG0494@2|Bacteria,COG2062@2|Bacteria,2GNRV@201174|Actinobacteria,4FF7Y@85021|Intrasporangiaceae	201174|Actinobacteria	L	phosphohistidine phosphatase	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
TLS3_k127_7201566_0	367299.JOEE01000006_gene669	0.0	1128.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4FEPC@85021|Intrasporangiaceae	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
TLS3_k127_7201566_34	367299.JOEE01000006_gene671	6.848e-71	261.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4FGE6@85021|Intrasporangiaceae	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
TLS3_k127_7201566_31	1385519.N801_18545	3.172e-97	342.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4FE75@85021|Intrasporangiaceae	201174|Actinobacteria	KT	Transcriptional regulator	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
TLS3_k127_7201566_53	1121017.AUFG01000009_gene1545	4.465e-16	81.0	COG1977@1|root,COG1977@2|Bacteria,2HXWK@201174|Actinobacteria,4FI5H@85021|Intrasporangiaceae	201174|Actinobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
TLS3_k127_7201566_44	367299.JOEE01000006_gene674	2.192e-42	167.0	2DJPX@1|root,32UDI@2|Bacteria,2IFS0@201174|Actinobacteria,4FHW4@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7201566_50	1246474.ANBE01000022_gene3926	1.563e-30	134.0	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria,4EJN0@85012|Streptosporangiales	201174|Actinobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
TLS3_k127_7201566_33	1385521.N803_03720	1.123e-87	292.0	COG4044@1|root,COG4044@2|Bacteria,2GKGF@201174|Actinobacteria,4FFNT@85021|Intrasporangiaceae	201174|Actinobacteria	S	May play a role in the intracellular transport of hydrophobic ligands	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1794
TLS3_k127_7201566_18	1385520.N802_13380	2.577e-126	415.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4FE46@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
TLS3_k127_7201566_46	1385519.N801_19265	5.788e-38	146.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria,4FHEY@85021|Intrasporangiaceae	201174|Actinobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
TLS3_k127_7201566_10	710696.Intca_2944	8.367e-145	473.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4FFVS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
TLS3_k127_7201566_39	1194165.CAJF01000007_gene639	5.765e-55	201.0	COG4244@1|root,COG4244@2|Bacteria,2II9W@201174|Actinobacteria,4FPU9@85023|Microbacteriaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
TLS3_k127_7201566_9	1385521.N803_03740	1.864e-152	486.0	COG3246@1|root,COG3246@2|Bacteria,2I9EQ@201174|Actinobacteria,4FF2K@85021|Intrasporangiaceae	201174|Actinobacteria	S	3-keto-5-aminohexanoate cleavage protein	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
TLS3_k127_7201566_41	1385519.N801_19280	2.372e-46	171.0	2DMC7@1|root,32J0V@2|Bacteria,2I81N@201174|Actinobacteria,4FK3D@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
TLS3_k127_7201566_42	1193181.BN10_890019	1.426e-45	171.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4FGUQ@85021|Intrasporangiaceae	201174|Actinobacteria	K	DNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
TLS3_k127_7201566_40	313589.JNB_16319	4.793e-49	185.0	2ED1B@1|root,336YA@2|Bacteria,2IQ3S@201174|Actinobacteria,4FGWF@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7201566_22	1385521.N803_03760	1.235e-113	375.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4FEKI@85021|Intrasporangiaceae	201174|Actinobacteria	E	asparaginase	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
TLS3_k127_7201566_38	521393.JH806632_gene571	4.631e-57	203.0	COG1490@1|root,COG1490@2|Bacteria,2IKVR@201174|Actinobacteria,4D62Q@85005|Actinomycetales	201174|Actinobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
TLS3_k127_7201566_51	1172188.KB911830_gene3846	5.867e-26	109.0	2EHMU@1|root,33BDI@2|Bacteria,2GQGA@201174|Actinobacteria,4FHT4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2516)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2516
TLS3_k127_7201566_45	1210046.B277_08874	7.459e-39	154.0	COG0662@1|root,COG0662@2|Bacteria,2IPIR@201174|Actinobacteria,4FH33@85021|Intrasporangiaceae	201174|Actinobacteria	G	Mannose-6-phosphate isomerase	-	-	2.7.7.13,5.3.1.8	ko:K01809,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer
TLS3_k127_7201566_25	1172188.KB911830_gene3843	2.972e-104	344.0	COG4122@1|root,COG4122@2|Bacteria,2GK2F@201174|Actinobacteria,4FF27@85021|Intrasporangiaceae	201174|Actinobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7201566_37	367299.JOEE01000006_gene691	5.746e-59	224.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria,4FGHN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS3_k127_7201566_15	1210046.B277_08849	9.096e-135	431.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria,4FEZP@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS3_k127_7201566_27	1385518.N798_00435	1.18e-100	333.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4FEIT@85021|Intrasporangiaceae	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
TLS3_k127_7201566_17	1385519.N801_19340	8.822e-127	419.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4FEMZ@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
TLS3_k127_7201566_43	1184609.KILIM_027_00200	3.578e-43	160.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4F6SG@85018|Dermatophilaceae	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_7202_2	1184609.KILIM_004_00610	2.627e-107	355.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4F63K@85018|Dermatophilaceae	201174|Actinobacteria	EM	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
TLS3_k127_7202_1	367299.JOEE01000003_gene2678	1.429e-295	927.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4FFG7@85021|Intrasporangiaceae	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
TLS3_k127_7202_0	1121017.AUFG01000020_gene2312	0.0	1072.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4FEFA@85021|Intrasporangiaceae	201174|Actinobacteria	D	Cell division protein FtsK	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
TLS3_k127_7202_5	1123065.ATWL01000045_gene1070	2.946e-28	122.0	COG5340@1|root,COG5340@2|Bacteria,2ICBY@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
TLS3_k127_7202_6	1123065.ATWL01000045_gene1070	2.636e-20	102.0	COG5340@1|root,COG5340@2|Bacteria,2ICBY@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
TLS3_k127_7202_3	35754.JNYJ01000027_gene6166	1.832e-102	343.0	COG2342@1|root,COG2342@2|Bacteria,2HTWT@201174|Actinobacteria,4D97J@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_114
TLS3_k127_7202_4	35754.JNYJ01000027_gene6171	4.311e-69	241.0	28KNN@1|root,2ZA6V@2|Bacteria,2I2ZK@201174|Actinobacteria,4D92Z@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7214711_4	1385518.N798_06935	2.205e-09	62.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4FGD7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
TLS3_k127_7214711_0	101510.RHA1_ro00788	4.815e-94	338.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FUTU@85025|Nocardiaceae	201174|Actinobacteria	K	activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22,GerE,NB-ARC,Pkinase,TPR_12,TPR_7
TLS3_k127_7214711_3	309801.trd_1922	2.013e-17	97.0	COG0028@1|root,COG3055@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria,2GBSZ@200795|Chloroflexi,27ZA5@189775|Thermomicrobia	189775|Thermomicrobia	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7214711_1	1089545.KB913037_gene1380	1.791e-65	228.0	COG3153@1|root,COG3153@2|Bacteria,2I58Y@201174|Actinobacteria	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_7214711_2	1122609.AUGT01000005_gene1566	6.325e-46	168.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4DQZ4@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
TLS3_k127_729287_7	1385519.N801_16725	5.097e-37	140.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4FF8Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
TLS3_k127_729287_2	1386089.N865_06810	8.17e-293	904.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4FE4V@85021|Intrasporangiaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
TLS3_k127_729287_9	1385521.N803_02265	7.939e-29	129.0	COG0355@1|root,COG0355@2|Bacteria,2IHNZ@201174|Actinobacteria,4FHIU@85021|Intrasporangiaceae	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
TLS3_k127_729287_10	1121385.AQXW01000004_gene1726	3.512e-16	84.0	2EU1Y@1|root,3294D@2|Bacteria,2I0WE@201174|Actinobacteria,1ZX2N@145357|Dermacoccaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2550)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2550
TLS3_k127_729287_6	1385519.N801_16745	1.858e-93	311.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,4FEPB@85021|Intrasporangiaceae	201174|Actinobacteria	S	Cob(I)yrinic acid a,c-diamide adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
TLS3_k127_729287_8	1385518.N798_16370	1.29e-32	141.0	COG2311@1|root,COG2311@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF1624,DUF418
TLS3_k127_729287_0	1172188.KB911821_gene1573	0.0	1088.0	COG2185@1|root,COG2185@2|Bacteria,2I2N3@201174|Actinobacteria,4FEHX@85021|Intrasporangiaceae	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	meaA	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
TLS3_k127_729287_5	1193181.BN10_1170023	2.772e-126	412.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria,4FF1P@85021|Intrasporangiaceae	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
TLS3_k127_729287_11	1385520.N802_06045	5.78e-13	75.0	2B7WT@1|root,3213R@2|Bacteria,2H511@201174|Actinobacteria,4FJ71@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_729287_1	1193181.BN10_1170022	1.193e-312	966.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4FEPZ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
TLS3_k127_729287_4	1385521.N803_02180	5.44e-136	449.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4FF6V@85021|Intrasporangiaceae	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
TLS3_k127_729287_3	1193181.BN10_1170017	2.865e-194	606.0	COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4FFKA@85021|Intrasporangiaceae	201174|Actinobacteria	C	NADPH quinone reductase	ccr	-	1.3.1.86	ko:K17829	ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200	-	R09738	RC00076	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_7293278_3	367299.JOEE01000004_gene1253	1.47e-120	394.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4FEHR@85021|Intrasporangiaceae	201174|Actinobacteria	I	AMP-dependent synthetase	fadD11_1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_7293278_4	1121385.AQXW01000003_gene610	4.124e-116	385.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,1ZVMJ@145357|Dermacoccaceae	201174|Actinobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
TLS3_k127_7293278_1	313589.JNB_20348	2.744e-134	439.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4FEHC@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
TLS3_k127_7293278_5	1385519.N801_19005	7.209e-116	386.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4FEDD@85021|Intrasporangiaceae	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
TLS3_k127_7293278_6	367299.JOEE01000004_gene1249	9.66e-57	201.0	COG0858@1|root,COG0858@2|Bacteria,2IKXP@201174|Actinobacteria,4FGS0@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
TLS3_k127_7293278_7	1121927.GOHSU_38_00470	1.156e-31	132.0	COG2847@1|root,COG2847@2|Bacteria,2IR3D@201174|Actinobacteria,4GE6F@85026|Gordoniaceae	201174|Actinobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
TLS3_k127_7293278_2	1386089.N865_17965	1.019e-128	427.0	COG2837@1|root,COG2837@2|Bacteria,2GIUB@201174|Actinobacteria,4FG83@85021|Intrasporangiaceae	201174|Actinobacteria	P	Dyp-type peroxidase family	-	-	1.11.1.19	ko:K15733	-	-	-	-	ko00000,ko01000	-	-	-	Dyp_perox
TLS3_k127_7293278_0	1193181.BN10_370001	0.0	1005.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4FEB5@85021|Intrasporangiaceae	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
TLS3_k127_7302179_9	196162.Noca_0543	4.915e-50	184.0	COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,4DR9U@85009|Propionibacteriales	201174|Actinobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
TLS3_k127_7302179_4	196162.Noca_0542	1.427e-151	487.0	COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria,4DT4I@85009|Propionibacteriales	201174|Actinobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
TLS3_k127_7302179_5	1172188.KB911821_gene2021	6.603e-113	374.0	COG1879@1|root,COG1879@2|Bacteria,2GN16@201174|Actinobacteria,4FFSB@85021|Intrasporangiaceae	201174|Actinobacteria	K	Periplasmic binding protein domain	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
TLS3_k127_7302179_3	1193181.BN10_10012	6.945e-171	539.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4FFQ9@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
TLS3_k127_7302179_6	1193181.BN10_10014	7.359e-73	253.0	COG0730@1|root,COG0730@2|Bacteria,2GK5W@201174|Actinobacteria,4FF8G@85021|Intrasporangiaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
TLS3_k127_7302179_0	1385520.N802_04255	4.321e-278	889.0	COG0477@1|root,COG0664@1|root,COG1752@1|root,COG0477@2|Bacteria,COG0664@2|Bacteria,COG1752@2|Bacteria,2GMEJ@201174|Actinobacteria,4FJVQ@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Belongs to the major facilitator superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	MFS_1,MFS_3,Patatin,Sugar_tr,cNMP_binding
TLS3_k127_7302179_2	1385521.N803_11685	3.944e-173	556.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4FG60@85021|Intrasporangiaceae	201174|Actinobacteria	E	gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
TLS3_k127_7302179_1	313589.JNB_13918	2.227e-188	599.0	COG0534@1|root,COG0534@2|Bacteria,2GJE3@201174|Actinobacteria,4FFX8@85021|Intrasporangiaceae	201174|Actinobacteria	V	Multidrug transporter MatE	dinF	-	-	-	-	-	-	-	-	-	-	-	MatE
TLS3_k127_7302179_8	1385519.N801_07415	1.823e-54	204.0	COG2852@1|root,COG2852@2|Bacteria,2IPC8@201174|Actinobacteria,4FH1D@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7302179_7	1193181.BN10_300012	1.03e-56	208.0	2E4WR@1|root,32ZQT@2|Bacteria,2IP6G@201174|Actinobacteria,4FH4R@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7334433_6	1193181.BN10_50017	3.149e-12	67.0	COG2304@1|root,COG2304@2|Bacteria,2GUB3@201174|Actinobacteria,4FFUP@85021|Intrasporangiaceae	201174|Actinobacteria	P	Von Willebrand factor	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,VWA
TLS3_k127_7334433_1	367299.JOEE01000002_gene2402	1.017e-194	610.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria,4FFNG@85021|Intrasporangiaceae	201174|Actinobacteria	M	UDP-glucose 4-epimerase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
TLS3_k127_7334433_5	1122622.ATWJ01000013_gene23	5.515e-90	314.0	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,4FGEH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009405,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704	-	-	-	-	-	-	-	-	-	-	DUF2254
TLS3_k127_7334433_0	367299.JOEE01000002_gene2403	7.165e-221	694.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4FFIS@85021|Intrasporangiaceae	201174|Actinobacteria	C	cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
TLS3_k127_7334433_3	367299.JOEE01000002_gene2404	5.162e-146	472.0	COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria,4FEJA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome C oxidase assembly protein	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
TLS3_k127_7334433_2	367299.JOEE01000002_gene2405	1.837e-184	593.0	COG4988@1|root,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria,4FFQC@85021|Intrasporangiaceae	201174|Actinobacteria	V	ABC transporter	cydD	-	-	ko:K16013,ko:K16014	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
TLS3_k127_7334433_4	367299.JOEE01000002_gene2406	2.414e-117	411.0	COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4FF8E@85021|Intrasporangiaceae	201174|Actinobacteria	CO	ABC transporter, ATP-binding protein	cydC	-	-	ko:K06148,ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.129	-	-	ABC_membrane,ABC_tran
TLS3_k127_7351485_4	1380347.JNII01000012_gene2714	0.0003365	45.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4ESAP@85013|Frankiales	201174|Actinobacteria	C	cytochrome P-450	cyp20	-	1.14.14.1	ko:K00493	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko01000	-	-	-	p450
TLS3_k127_7351485_2	1193181.BN10_250002	5.328e-36	139.0	COG4309@1|root,COG4309@2|Bacteria,2GS7C@201174|Actinobacteria,4FHNY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249,Hemerythrin
TLS3_k127_7351485_0	1122622.ATWJ01000013_gene177	8.262e-298	942.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GPUP@201174|Actinobacteria,4FG4T@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
TLS3_k127_7351485_3	1146883.BLASA_4883	3.825e-30	130.0	COG2345@1|root,COG2345@2|Bacteria,2IAWJ@201174|Actinobacteria,4ESV7@85013|Frankiales	201174|Actinobacteria	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR,MarR_2
TLS3_k127_7351485_1	1385518.N798_05845	2.22e-62	217.0	COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4FGN6@85021|Intrasporangiaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
TLS3_k127_7384019_25	1123024.AUII01000006_gene4555	6.652e-13	74.0	COG0699@1|root,COG4585@1|root,COG0699@2|Bacteria,COG4585@2|Bacteria,2GSBK@201174|Actinobacteria,4E183@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS3_k127_7384019_0	1120948.KB903244_gene2776	0.0	1432.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4E262@85010|Pseudonocardiales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS3_k127_7384019_22	1120948.KB903244_gene2776	2.1e-29	123.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4E262@85010|Pseudonocardiales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
TLS3_k127_7384019_23	2074.JNYD01000019_gene2551	6.541e-28	132.0	COG5485@1|root,COG5485@2|Bacteria,2HSDQ@201174|Actinobacteria,4EDD0@85010|Pseudonocardiales	201174|Actinobacteria	S	Ester cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7384019_18	675635.Psed_2036	1.124e-74	261.0	COG0262@1|root,COG0262@2|Bacteria,2GJU5@201174|Actinobacteria,4DZI1@85010|Pseudonocardiales	201174|Actinobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
TLS3_k127_7384019_7	1120948.KB903244_gene2775	5.816e-190	599.0	COG0435@1|root,COG0435@2|Bacteria,2GIXK@201174|Actinobacteria,4DXH5@85010|Pseudonocardiales	201174|Actinobacteria	O	Glutathione S-transferase	yqjG	-	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
TLS3_k127_7384019_2	1120948.KB903244_gene2774	1.048e-318	1015.0	COG0028@1|root,COG0028@2|Bacteria,2GJ20@201174|Actinobacteria,4DXMI@85010|Pseudonocardiales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_7384019_20	1123024.AUII01000011_gene4464	2.963e-63	224.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria	201174|Actinobacteria	F	glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase
TLS3_k127_7384019_17	710111.FraQA3DRAFT_3143	4.419e-79	281.0	COG1396@1|root,COG1396@2|Bacteria,2GK9T@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
TLS3_k127_7384019_3	1123024.AUII01000011_gene4461	9.436e-290	894.0	COG0069@1|root,COG0069@2|Bacteria,2GME2@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9,Glu_syn_central,Glu_synthase
TLS3_k127_7384019_13	1123023.JIAI01000007_gene1969	6.691e-120	404.0	COG2218@1|root,COG2218@2|Bacteria,2I686@201174|Actinobacteria	201174|Actinobacteria	C	Glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
TLS3_k127_7384019_11	1123024.AUII01000011_gene4459	3.972e-167	542.0	COG0034@1|root,COG0034@2|Bacteria,2I3P1@201174|Actinobacteria	201174|Actinobacteria	F	Glutamine amidotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase_6
TLS3_k127_7384019_4	1123023.JIAI01000007_gene1967	4.044e-283	873.0	COG0174@1|root,COG0174@2|Bacteria,2I8RB@201174|Actinobacteria	201174|Actinobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
TLS3_k127_7384019_26	1297570.MESS4_370128	4e-05	56.0	2E7A9@1|root,331TT@2|Bacteria,1NE46@1224|Proteobacteria,2UHHC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7384019_8	314270.RB2083_2711	6.362e-184	591.0	COG0004@1|root,COG0004@2|Bacteria,1MX44@1224|Proteobacteria,2TR55@28211|Alphaproteobacteria,3ZGPX@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	P	Ammonium transporter family protein	amt	-	-	-	-	-	-	-	-	-	-	-	Ammonium_transp
TLS3_k127_7384019_9	314231.FP2506_16694	1.845e-169	546.0	COG0004@1|root,COG0004@2|Bacteria,1R7MK@1224|Proteobacteria,2U20H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS3_k127_7384019_1	1123024.AUII01000011_gene4445	0.0	1330.0	COG0404@1|root,COG3665@1|root,COG0404@2|Bacteria,COG3665@2|Bacteria,2GJ47@201174|Actinobacteria,4DXZ6@85010|Pseudonocardiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	-	-	-	-	-	-	-	-	-	-	-	-	DUF1989,FAO_M,GCV_T,GCV_T_C
TLS3_k127_7384019_6	1114959.SZMC14600_04021	2.356e-231	728.0	COG2072@1|root,COG2072@2|Bacteria,2GMDH@201174|Actinobacteria,4E8VD@85010|Pseudonocardiales	201174|Actinobacteria	P	flavoprotein involved in K transport	-	-	1.14.13.148	ko:K18277	ko00680,map00680	-	R05623	RC00058	ko00000,ko00001,ko01000	-	-	-	FMO-like
TLS3_k127_7384019_24	1380391.JIAS01000011_gene5196	9.124e-28	123.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2UC7G@28211|Alphaproteobacteria,2JTQX@204441|Rhodospirillales	204441|Rhodospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
TLS3_k127_7384019_15	1123024.AUII01000011_gene4453	6.758e-89	299.0	COG1414@1|root,COG1414@2|Bacteria,2IJ2P@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS3_k127_7384019_5	1123024.AUII01000011_gene4452	1.686e-236	738.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO
TLS3_k127_7384019_12	1123024.AUII01000011_gene4451	6.094e-135	442.0	COG0788@1|root,COG0788@2|Bacteria,2GM0G@201174|Actinobacteria,4E2AN@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
TLS3_k127_7384019_14	1123024.AUII01000011_gene4449	2.519e-109	378.0	COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria,4DXDF@85010|Pseudonocardiales	201174|Actinobacteria	S	Nitronate monooxygenase	-	GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007623,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012505,GO:0016192,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034404,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0042278,GO:0042451,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046903,GO:0048511,GO:0050896,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097708,GO:0099503,GO:0101002,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1904813	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
TLS3_k127_7384019_10	266940.Krad_4210	1.877e-168	543.0	COG0477@1|root,COG0477@2|Bacteria,2GIYR@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
TLS3_k127_7384019_19	1120948.KB903244_gene2773	1.314e-64	222.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4E3SA@85010|Pseudonocardiales	201174|Actinobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
TLS3_k127_7384019_21	1463853.JOHW01000002_gene5799	4.721e-52	199.0	COG2230@1|root,COG2230@2|Bacteria,2GKD3@201174|Actinobacteria	201174|Actinobacteria	M	SAM dependent carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_7
TLS3_k127_7467441_9	1184609.KILIM_077_00150	3.866e-161	515.0	COG0747@1|root,COG0747@2|Bacteria,2GMMG@201174|Actinobacteria	201174|Actinobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
TLS3_k127_7467441_7	1184609.KILIM_077_00140	3.974e-230	722.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
TLS3_k127_7467441_11	1479623.JHEL01000015_gene946	7.493e-137	449.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4FK7A@85023|Microbacteriaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
TLS3_k127_7467441_22	1184609.KILIM_077_00120	3.974e-22	105.0	2E7VQ@1|root,332AI@2|Bacteria,2IQPN@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
TLS3_k127_7467441_5	1184609.KILIM_077_00110	1.552e-285	892.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
TLS3_k127_7467441_21	1120954.ATXE01000003_gene461	2.193e-27	119.0	COG0619@1|root,COG0619@2|Bacteria,2IQMQ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type cobalt transport system permease component CbiQ	bioN	-	-	ko:K16783	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25.1	-	-	CbiQ
TLS3_k127_7467441_17	1068978.AMETH_2793	1.226e-63	229.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4DZKU@85010|Pseudonocardiales	201174|Actinobacteria	P	ABC-type cobalt transport system, ATPase component	bioM	-	-	ko:K16784	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25.1	-	-	ABC_tran
TLS3_k127_7467441_14	1385519.N801_12675	5.253e-113	376.0	COG0183@1|root,COG0183@2|Bacteria,2GM29@201174|Actinobacteria,4FEZE@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the thiolase family	yhfS	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_7467441_16	1385519.N801_12670	2.984e-65	244.0	COG0318@1|root,COG0318@2|Bacteria,2I908@201174|Actinobacteria,4FIYZ@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
TLS3_k127_7467441_20	1122611.KB903940_gene1861	1.107e-45	176.0	COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria,4EIYG@85012|Streptosporangiales	201174|Actinobacteria	S	BioY family	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
TLS3_k127_7467441_10	1386089.N865_06605	3.298e-151	484.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4FE5Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
TLS3_k127_7467441_12	1172188.KB911821_gene1538	7.698e-133	428.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4FEFQ@85021|Intrasporangiaceae	201174|Actinobacteria	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
TLS3_k127_7467441_18	351607.Acel_1461	4.174e-54	214.0	COG2247@1|root,COG4934@1|root,COG2247@2|Bacteria,COG4934@2|Bacteria,2HEYG@201174|Actinobacteria,4EVX7@85013|Frankiales	2|Bacteria	M	Pro-kumamolisin, activation domain	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	CW_binding_2,Peptidase_S8,Pro-kuma_activ,fn3
TLS3_k127_7467441_23	1123393.KB891316_gene1613	5.675e-14	86.0	2C1AX@1|root,33GUX@2|Bacteria,1MZSH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7467441_13	1385519.N801_13740	2.1e-115	379.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4FFKY@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS3_k127_7467441_19	313589.JNB_19053	2.204e-46	174.0	2EBTY@1|root,335TG@2|Bacteria,2INPD@201174|Actinobacteria,4FGTB@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
TLS3_k127_7467441_3	1385518.N798_17005	7.973e-317	998.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4FEI7@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
TLS3_k127_7467441_1	367299.JOEE01000004_gene1040	0.0	1043.0	COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria,4FEI1@85021|Intrasporangiaceae	201174|Actinobacteria	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
TLS3_k127_7467441_2	367299.JOEE01000004_gene1039	0.0	1019.0	COG0366@1|root,COG0366@2|Bacteria,2GIV1@201174|Actinobacteria,4FFAA@85021|Intrasporangiaceae	201174|Actinobacteria	G	Trehalose synthase	treS	GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	iNJ661.Rv0126	Alpha-amylase,Malt_amylase_C
TLS3_k127_7467441_8	1385518.N798_16555	3.725e-178	574.0	COG3281@1|root,COG3281@2|Bacteria,2GKAP@201174|Actinobacteria,4FEUH@85021|Intrasporangiaceae	201174|Actinobacteria	G	Aminoglycoside phosphotransferase	mak	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.7.1.175	ko:K16146	ko00500,ko01100,map00500,map01100	-	R09945	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
TLS3_k127_7467441_0	1385518.N798_16550	0.0	1252.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4FFH4@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
TLS3_k127_7467441_4	367299.JOEE01000004_gene1033	1.156e-311	965.0	COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria,4FFBE@85021|Intrasporangiaceae	201174|Actinobacteria	G	Phosphoglucomutase	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_7467441_6	1385518.N798_16535	1.074e-232	724.0	COG0189@1|root,COG0189@2|Bacteria,2I5WV@201174|Actinobacteria,4FF3F@85021|Intrasporangiaceae	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7467441_15	1385521.N803_02070	5.389e-104	343.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4FFF6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
TLS3_k127_7492295_0	367299.JOEE01000001_gene1871	0.0	1116.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4FF8U@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS3_k127_7492295_3	1184609.KILIM_003_00700	2.552e-100	331.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4F6GX@85018|Dermatophilaceae	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_7492295_2	1184609.KILIM_003_00690	2.237e-158	516.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
TLS3_k127_7492295_7	1122622.ATWJ01000008_gene2826	3.005e-54	196.0	COG3409@1|root,COG3409@2|Bacteria,2IM37@201174|Actinobacteria,4FHJ0@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7492295_6	1193181.BN10_580025	2.624e-81	287.0	COG1946@1|root,COG1946@2|Bacteria,2GMZB@201174|Actinobacteria,4FG7M@85021|Intrasporangiaceae	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
TLS3_k127_7492295_9	1370121.AUWS01000018_gene6891	6.971e-21	97.0	COG0589@1|root,COG0589@2|Bacteria,2IS5J@201174|Actinobacteria,239B0@1762|Mycobacteriaceae	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
TLS3_k127_7492295_1	1385519.N801_16890	5.07e-180	583.0	COG4147@1|root,COG4147@2|Bacteria,2GM3H@201174|Actinobacteria,4FFFQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
TLS3_k127_7492295_8	1123251.ATWM01000009_gene2949	5.917e-24	111.0	2E3NY@1|root,32YM2@2|Bacteria,2II83@201174|Actinobacteria,4FHKR@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
TLS3_k127_7492295_4	1184607.AUCHE_04_00730	5.922e-96	326.0	COG3279@1|root,COG3279@2|Bacteria,2GKK5@201174|Actinobacteria,4F67H@85018|Dermatophilaceae	201174|Actinobacteria	K	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
TLS3_k127_7492295_5	367299.JOEE01000001_gene1882	1.489e-89	297.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria,4FE5E@85021|Intrasporangiaceae	201174|Actinobacteria	T	Signal transduction histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,His_kinase
TLS3_k127_7547068_1	1385520.N802_16580	2.826e-188	590.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4FFZM@85021|Intrasporangiaceae	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47	ko:K12339,ko:K21148	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021	R00897,R03132,R03601,R04859,R10610	RC00020,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_7547068_5	1032480.MLP_10350	1.741e-63	228.0	COG0346@1|root,COG0346@2|Bacteria,2IQE0@201174|Actinobacteria,4DS3K@85009|Propionibacteriales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
TLS3_k127_7547068_6	1172188.KB911820_gene2520	7.294e-56	199.0	COG0454@1|root,COG0456@2|Bacteria,2GPVQ@201174|Actinobacteria,4FJJK@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_7547068_8	443218.AS9A_2339	2.826e-16	81.0	291UT@1|root,2ZPEM@2|Bacteria,2H9SK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7547068_3	1123251.ATWM01000001_gene651	3.736e-131	432.0	COG0644@1|root,COG0644@2|Bacteria,2GNH7@201174|Actinobacteria	201174|Actinobacteria	C	lycopene cyclase	crtL	-	5.5.1.19	ko:K06443	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R03824,R04801,R05341,R06962,R07856	RC01004,RC01964	ko00000,ko00001,ko00002,ko01000	-	-	-	Lycopene_cycl
TLS3_k127_7547068_7	2074.JNYD01000016_gene4262	6.071e-20	96.0	COG3427@1|root,COG3427@2|Bacteria,2ISXG@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
TLS3_k127_7547068_4	1172186.KB911465_gene4275	1.38e-67	235.0	COG0431@1|root,COG0431@2|Bacteria,2GNFR@201174|Actinobacteria,2388S@1762|Mycobacteriaceae	201174|Actinobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS3_k127_7547068_0	710696.Intca_2870	1.838e-226	708.0	COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4FFF5@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
TLS3_k127_7547068_2	313589.JNB_16519	2.245e-174	580.0	COG2271@1|root,COG2271@2|Bacteria,2I2F7@201174|Actinobacteria,4FFEJ@85021|Intrasporangiaceae	201174|Actinobacteria	G	MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_7609758_1	1122622.ATWJ01000008_gene2681	7.403e-172	550.0	COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4FEXC@85021|Intrasporangiaceae	201174|Actinobacteria	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
TLS3_k127_7609758_2	1122622.ATWJ01000008_gene2682	2.678e-155	511.0	COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,4FF69@85021|Intrasporangiaceae	201174|Actinobacteria	EH	With CysN catalyzes the formation of adenylylsulfate from sulfate and ATP	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
TLS3_k127_7609758_3	1122622.ATWJ01000008_gene2683	9.802e-99	333.0	COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,4FEUD@85021|Intrasporangiaceae	201174|Actinobacteria	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2392	PAPS_reduct
TLS3_k127_7609758_0	1122622.ATWJ01000008_gene2684	2.2e-284	887.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4FF1X@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	sir	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
TLS3_k127_7609758_4	529884.Rhola_00012410	2.309e-13	71.0	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4FNRH@85023|Microbacteriaceae	201174|Actinobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
TLS3_k127_7617578_35	367299.JOEE01000004_gene1098	6.919e-57	200.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4FEDG@85021|Intrasporangiaceae	201174|Actinobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
TLS3_k127_7617578_11	367299.JOEE01000004_gene1099	5.787e-182	580.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4FEYA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
TLS3_k127_7617578_29	710696.Intca_2354	3.405e-77	268.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4FGCS@85021|Intrasporangiaceae	201174|Actinobacteria	S	haloacid dehalogenase-like hydrolase	cof	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
TLS3_k127_7617578_21	367299.JOEE01000004_gene1108	3.483e-125	411.0	COG2220@1|root,COG2220@2|Bacteria,2GNXJ@201174|Actinobacteria,4FFCV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Zn-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
TLS3_k127_7617578_26	2045.KR76_15505	4.311e-93	314.0	COG1051@1|root,COG1051@2|Bacteria,2GNMT@201174|Actinobacteria,4DPTQ@85009|Propionibacteriales	201174|Actinobacteria	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS3_k127_7617578_33	1229203.KI301992_gene743	1.455e-68	239.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,3UWWF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	Q	Isochorismatase family	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
TLS3_k127_7617578_14	935866.JAER01000052_gene2865	3.129e-163	527.0	COG1335@1|root,COG1488@1|root,COG1335@2|Bacteria,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4DN3A@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
TLS3_k127_7617578_3	367299.JOEE01000004_gene1110	3.256e-269	842.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4FFM3@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
TLS3_k127_7617578_1	367299.JOEE01000004_gene1041	0.0	1326.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4FFHK@85021|Intrasporangiaceae	201174|Actinobacteria	G	phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
TLS3_k127_7617578_23	367299.JOEE01000004_gene1118	1.248e-111	367.0	2BYH3@1|root,2Z7SZ@2|Bacteria,2GMTF@201174|Actinobacteria,4FFGV@85021|Intrasporangiaceae	201174|Actinobacteria	S	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7617578_17	367299.JOEE01000004_gene1120	3.435e-143	456.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4FESR@85021|Intrasporangiaceae	201174|Actinobacteria	Q	2-hydroxyhepta-2,4-diene-1,7-dioate isomerase	fahA	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
TLS3_k127_7617578_6	1385518.N798_17410	2.334e-256	797.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4FET0@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
TLS3_k127_7617578_50	1298860.AUEM01000005_gene2736	0.0009127	49.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS3_k127_7617578_19	1385518.N798_17425	1.603e-129	443.0	COG1414@1|root,COG1414@2|Bacteria,2GKB0@201174|Actinobacteria,4FEDT@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator	ltbR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
TLS3_k127_7617578_4	367299.JOEE01000004_gene1130	5.156e-264	818.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4FE5P@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
TLS3_k127_7617578_25	1385520.N802_18860	2.781e-104	349.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4FE44@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2987c	Aconitase_C
TLS3_k127_7617578_38	1121385.AQXW01000003_gene436	1.118e-43	166.0	COG0776@1|root,COG0776@2|Bacteria,2GV0M@201174|Actinobacteria,1ZW6T@145357|Dermacoccaceae	201174|Actinobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
TLS3_k127_7617578_48	1121946.AUAX01000009_gene4460	1.742e-15	80.0	COG1920@1|root,COG1920@2|Bacteria,2GQPF@201174|Actinobacteria,4DFSM@85008|Micromonosporales	201174|Actinobacteria	S	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7617578_47	1415166.NONO_c56690	4.402e-20	98.0	COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria,4FYS3@85025|Nocardiaceae	201174|Actinobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
TLS3_k127_7617578_27	1386089.N865_17945	5.107e-93	314.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria,4FFUB@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_7617578_16	1385519.N801_14135	1.117e-145	471.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4FEJQ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
TLS3_k127_7617578_18	1385520.N802_18890	2.136e-140	455.0	COG0626@1|root,COG0626@2|Bacteria,2GMD8@201174|Actinobacteria,4FG2D@85021|Intrasporangiaceae	201174|Actinobacteria	E	cystathionine gamma-synthase	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
TLS3_k127_7617578_13	367299.JOEE01000004_gene1137	1.876e-168	544.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4FEUY@85021|Intrasporangiaceae	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
TLS3_k127_7617578_40	1386089.N865_17925	3.844e-41	161.0	2CQFE@1|root,32SM3@2|Bacteria,2IR42@201174|Actinobacteria,4FH43@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3515)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3515
TLS3_k127_7617578_44	1193181.BN10_450002	1.64e-30	126.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4FHC8@85021|Intrasporangiaceae	201174|Actinobacteria	K	AsnC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
TLS3_k127_7617578_24	1385518.N798_17485	5.793e-105	351.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4FG4Y@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
TLS3_k127_7617578_43	367299.JOEE01000004_gene1141	3.459e-31	126.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4FHCB@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
TLS3_k127_7617578_5	1385521.N803_16940	2.856e-261	824.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4FE3F@85021|Intrasporangiaceae	201174|Actinobacteria	L	ATP-dependent DNA helicase RecG	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
TLS3_k127_7617578_36	367299.JOEE01000004_gene1144	3.94e-54	198.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4FGPC@85021|Intrasporangiaceae	201174|Actinobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
TLS3_k127_7617578_32	367299.JOEE01000004_gene1145	2.26e-71	247.0	COG5592@1|root,COG5592@2|Bacteria,2IJ0S@201174|Actinobacteria,4FGU0@85021|Intrasporangiaceae	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
TLS3_k127_7617578_34	313589.JNB_19568	4.043e-64	224.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4FGNP@85021|Intrasporangiaceae	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS3_k127_7617578_10	367299.JOEE01000004_gene1147	3.035e-195	630.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4FE88@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
TLS3_k127_7617578_30	1193181.BN10_40009	3.556e-75	257.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,4FFUV@85021|Intrasporangiaceae	201174|Actinobacteria	S	metal-binding protein	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
TLS3_k127_7617578_46	1385520.N802_18950	2.244e-26	117.0	COG0333@1|root,COG0333@2|Bacteria,2GQP3@201174|Actinobacteria,4FHSH@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
TLS3_k127_7617578_28	44060.JODL01000009_gene1842	1.964e-80	288.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria	201174|Actinobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
TLS3_k127_7617578_20	1385519.N801_14210	6.648e-128	419.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4FF7W@85021|Intrasporangiaceae	201174|Actinobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
TLS3_k127_7617578_42	1193181.BN10_40004	5.123e-35	141.0	COG1254@1|root,COG1254@2|Bacteria,2IQ4M@201174|Actinobacteria,4FHHA@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
TLS3_k127_7617578_39	1385518.N798_04500	3.532e-42	157.0	COG1605@1|root,COG1605@2|Bacteria,2IQ46@201174|Actinobacteria,4FH4E@85021|Intrasporangiaceae	201174|Actinobacteria	E	chorismate mutase	tyrA	-	5.4.99.5	ko:K04092	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
TLS3_k127_7617578_15	290340.AAur_3946	1.436e-161	526.0	COG2270@1|root,COG2270@2|Bacteria,2GJSA@201174|Actinobacteria,1W8UW@1268|Micrococcaceae	201174|Actinobacteria	S	Major Facilitator Superfamily	cmr	-	-	ko:K18833	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.2	-	-	MFS_1
TLS3_k127_7617578_0	1385518.N798_04495	0.0	1475.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4FFAB@85021|Intrasporangiaceae	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
TLS3_k127_7617578_31	367299.JOEE01000004_gene1157	3.642e-72	252.0	COG0681@1|root,COG0681@2|Bacteria,2IMJG@201174|Actinobacteria,4FGBZ@85021|Intrasporangiaceae	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
TLS3_k127_7617578_49	313589.JNB_19623	2.31e-10	64.0	29YYC@1|root,30KV6@2|Bacteria,2GYTF@201174|Actinobacteria,4FHZC@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7617578_45	1172188.KB911824_gene3306	4.987e-28	117.0	COG4281@1|root,COG4281@2|Bacteria,2GS11@201174|Actinobacteria,4FHUU@85021|Intrasporangiaceae	201174|Actinobacteria	I	acyl-coA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ACBP
TLS3_k127_7617578_2	1193181.BN10_1460012	7.912e-310	960.0	COG3590@1|root,COG3590@2|Bacteria,2GNJY@201174|Actinobacteria,4FFVY@85021|Intrasporangiaceae	201174|Actinobacteria	O	peptidase M13	pepO	-	3.4.24.11,3.4.24.71	ko:K01389,ko:K01415,ko:K07386	ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
TLS3_k127_7617578_12	367299.JOEE01000004_gene1160	3.986e-173	552.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4FF05@85021|Intrasporangiaceae	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
TLS3_k127_7617578_41	313589.JNB_19653	3.56e-39	168.0	COG3011@1|root,COG3011@2|Bacteria,2IMHW@201174|Actinobacteria,4FHK2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
TLS3_k127_7617578_8	1123251.ATWM01000005_gene1505	1.637e-238	745.0	COG2070@1|root,COG2070@2|Bacteria,2I93H@201174|Actinobacteria,4FG2W@85021|Intrasporangiaceae	201174|Actinobacteria	S	2-Nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
TLS3_k127_7617578_9	743718.Isova_1181	3.082e-202	638.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4F3NT@85017|Promicromonosporaceae	201174|Actinobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
TLS3_k127_7617578_37	367299.JOEE01000004_gene1163	5.979e-50	198.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,4FH1F@85021|Intrasporangiaceae	201174|Actinobacteria	K	at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA)	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
TLS3_k127_7617578_7	1385521.N803_17050	2.171e-242	776.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,4FF82@85021|Intrasporangiaceae	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
TLS3_k127_7617578_22	1385519.N801_13465	1.277e-115	374.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4FEYZ@85021|Intrasporangiaceae	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
TLS3_k127_7661629_15	1043205.AFYF01000087_gene1150	1.686e-82	281.0	COG0454@1|root,COG0456@2|Bacteria,2I8DS@201174|Actinobacteria	201174|Actinobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_7661629_9	367299.JOEE01000002_gene2461	1.571e-104	358.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4FETQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
TLS3_k127_7661629_13	313589.JNB_11859	1.255e-89	306.0	COG0204@1|root,COG0204@2|Bacteria,2I8I4@201174|Actinobacteria,4FHMD@85021|Intrasporangiaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
TLS3_k127_7661629_4	313589.JNB_11874	8.801e-134	436.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4FG1M@85021|Intrasporangiaceae	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
TLS3_k127_7661629_20	313589.JNB_11879	4.166e-49	178.0	COG1196@1|root,COG1196@2|Bacteria,2IMXX@201174|Actinobacteria,4FHC2@85021|Intrasporangiaceae	201174|Actinobacteria	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
TLS3_k127_7661629_21	1120797.KB908279_gene2773	2.52e-30	121.0	COG1359@1|root,COG1359@2|Bacteria,2IS1M@201174|Actinobacteria,23ATF@1762|Mycobacteriaceae	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
TLS3_k127_7661629_12	494419.ALPM01000073_gene1535	1.372e-92	317.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria	201174|Actinobacteria	J	Phenazine biosynthesis protein PhzF	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
TLS3_k127_7661629_18	1386089.N865_15925	3.715e-56	200.0	COG1514@1|root,COG1514@2|Bacteria,2IKMG@201174|Actinobacteria,4FGYM@85021|Intrasporangiaceae	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS3_k127_7661629_17	446471.Xcel_2243	2.232e-69	241.0	COG1279@1|root,COG1279@2|Bacteria,2IHQ2@201174|Actinobacteria,4F4I2@85017|Promicromonosporaceae	201174|Actinobacteria	S	LysE type translocator	lysE	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902023,GO:1903825,GO:1903826,GO:1905039,GO:1990822	-	ko:K06895	-	-	-	-	ko00000,ko02000	2.A.75.1	-	-	LysE
TLS3_k127_7661629_11	1449058.JQKT01000007_gene550	4.578e-95	319.0	COG0583@1|root,COG0583@2|Bacteria,2GJEC@201174|Actinobacteria,4FNCE@85023|Microbacteriaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	iciA	GO:0001130,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003700,GO:0005488,GO:0006275,GO:0006355,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K05596	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	HTH_1,LysR_substrate
TLS3_k127_7661629_6	1298863.AUEP01000004_gene1887	7.738e-131	420.0	COG1357@1|root,COG1357@2|Bacteria,2GN74@201174|Actinobacteria,4DNE2@85009|Propionibacteriales	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,Pentapeptide
TLS3_k127_7661629_0	710421.Mycch_0373	2.334e-291	904.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,235IH@1762|Mycobacteriaceae	201174|Actinobacteria	I	synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
TLS3_k127_7661629_3	1385519.N801_16075	8.325e-165	542.0	COG1051@1|root,COG1051@2|Bacteria,2I2P7@201174|Actinobacteria,4FJZ0@85021|Intrasporangiaceae	201174|Actinobacteria	F	Pfam:DUF2029	-	-	-	-	-	-	-	-	-	-	-	-	GT87
TLS3_k127_7661629_2	1385518.N798_03390	6.113e-225	720.0	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4FECJ@85021|Intrasporangiaceae	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7661629_10	367299.JOEE01000002_gene2468	6.554e-98	338.0	2ACE4@1|root,311ZM@2|Bacteria,2HXCE@201174|Actinobacteria,4FG8C@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7661629_16	1121017.AUFG01000002_gene2814	6.08e-74	266.0	COG1215@1|root,COG1215@2|Bacteria,2GMKV@201174|Actinobacteria,4FEG0@85021|Intrasporangiaceae	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
TLS3_k127_7661629_8	1385520.N802_04470	1.689e-108	359.0	COG3012@1|root,COG3012@2|Bacteria,2GJ7F@201174|Actinobacteria,4FFM0@85021|Intrasporangiaceae	201174|Actinobacteria	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
TLS3_k127_7661629_19	1385521.N803_14790	2.39e-54	196.0	COG3920@1|root,COG3920@2|Bacteria,2II0F@201174|Actinobacteria,4FH2G@85021|Intrasporangiaceae	201174|Actinobacteria	T	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
TLS3_k127_7661629_14	1193181.BN10_580036	1.624e-86	302.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4FEA0@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K20469	-	-	-	-	ko00000,ko02000	2.A.86.1.7	-	-	AI-2E_transport
TLS3_k127_7661629_5	1122622.ATWJ01000009_gene3261	2.667e-131	435.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4FFTR@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
TLS3_k127_7661629_7	1307761.L21SP2_1692	2.336e-127	425.0	COG2211@1|root,COG2211@2|Bacteria,2J6VC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter	-	-	-	ko:K11104,ko:K16209,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
TLS3_k127_7661629_1	1386089.N865_01885	1.423e-226	715.0	COG2234@1|root,COG2234@2|Bacteria,2IDP0@201174|Actinobacteria,4FE57@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
TLS3_k127_7706839_2	1385519.N801_19345	1.519e-97	320.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4FEUK@85021|Intrasporangiaceae	201174|Actinobacteria	T	XRE family transcriptional regulator	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
TLS3_k127_7706839_8	367299.JOEE01000006_gene699	1.719e-13	77.0	2E56G@1|root,32ZZ6@2|Bacteria,2GR3Y@201174|Actinobacteria,4FHTB@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7706839_4	1172188.KB911830_gene3835	2.037e-89	295.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4FE53@85021|Intrasporangiaceae	201174|Actinobacteria	K	CarD family transcriptional regulator	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
TLS3_k127_7706839_6	367299.JOEE01000006_gene701	5.771e-71	247.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4FGMU@85021|Intrasporangiaceae	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
TLS3_k127_7706839_5	367299.JOEE01000006_gene702	3.489e-79	267.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4FGGE@85021|Intrasporangiaceae	201174|Actinobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3581c	YgbB
TLS3_k127_7706839_1	710696.Intca_0006	7.252e-162	524.0	COG3227@1|root,COG3227@2|Bacteria,2GJEW@201174|Actinobacteria,4FF3Z@85021|Intrasporangiaceae	201174|Actinobacteria	E	peptidase M4	prt1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M4,Peptidase_M4_C
TLS3_k127_7706839_7	1121385.AQXW01000004_gene3213	2.411e-26	116.0	COG1846@1|root,COG1846@2|Bacteria,2GV1A@201174|Actinobacteria	201174|Actinobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
TLS3_k127_7706839_0	1193181.BN10_1100009	2.362e-214	677.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4FF8S@85021|Intrasporangiaceae	201174|Actinobacteria	C	alcohol dehydrogenase	adhC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.306	ko:K00153	-	-	R09129,R10301	RC00069,RC01715	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
TLS3_k127_7706839_3	1193181.BN10_1100008	6.222e-97	326.0	COG0491@1|root,COG0491@2|Bacteria,2GJ7I@201174|Actinobacteria,4FGED@85021|Intrasporangiaceae	201174|Actinobacteria	S	Zn-dependent	blaB4	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
TLS3_k127_7769277_2	1386089.N865_16115	4.721e-139	450.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4FEAB@85021|Intrasporangiaceae	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS3_k127_7769277_4	367299.JOEE01000002_gene2628	7.437e-84	286.0	COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4FGWD@85021|Intrasporangiaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
TLS3_k127_7769277_0	477641.MODMU_1206	7.248e-187	598.0	COG1075@1|root,COG1075@2|Bacteria,2I9FH@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF900,PGAP1
TLS3_k127_7769277_3	1304865.JAGF01000001_gene2499	8.194e-131	437.0	COG0395@1|root,COG0395@2|Bacteria,2GK1V@201174|Actinobacteria,4F1QY@85016|Cellulomonadaceae	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K10242	ko02010,map02010	M00206,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.23	-	-	BPD_transp_1
TLS3_k127_7769277_1	1410634.JHVD01000003_gene1894	1.127e-144	469.0	COG1175@1|root,COG1175@2|Bacteria,2GMV4@201174|Actinobacteria,4DN9U@85009|Propionibacteriales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10241	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	BPD_transp_1
TLS3_k127_7772888_9	1385521.N803_02350	5.958e-14	74.0	COG5340@1|root,COG5340@2|Bacteria,2ICWZ@201174|Actinobacteria,4FFN7@85021|Intrasporangiaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS3_k127_7772888_6	1184609.KILIM_034_00130	5.283e-84	284.0	COG5340@1|root,COG5340@2|Bacteria,2ICWZ@201174|Actinobacteria	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
TLS3_k127_7772888_4	1385518.N798_03640	8.301e-97	330.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4FE73@85021|Intrasporangiaceae	201174|Actinobacteria	S	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
TLS3_k127_7772888_5	1386089.N865_16020	1.345e-91	302.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,4FFQH@85021|Intrasporangiaceae	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
TLS3_k127_7772888_8	1193181.BN10_1640002	2.207e-17	94.0	2EIMR@1|root,33CD0@2|Bacteria,2I7T4@201174|Actinobacteria,4FK2K@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7772888_0	1121933.AUHH01000040_gene3158	3.669e-239	762.0	COG1215@1|root,COG1215@2|Bacteria,2GN8M@201174|Actinobacteria	201174|Actinobacteria	M	probably involved in cell wall	-	-	-	-	-	-	-	-	-	-	-	-	EAL,Glyco_trans_2_3
TLS3_k127_7772888_1	1123251.ATWM01000002_gene78	1.308e-218	692.0	COG2141@1|root,COG2141@2|Bacteria,2GKRH@201174|Actinobacteria,4FEB3@85021|Intrasporangiaceae	201174|Actinobacteria	C	tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,Bac_luciferase,FAD_binding_4,Hemerythrin
TLS3_k127_7772888_3	1386089.N865_10935	3.079e-106	355.0	COG1540@1|root,COG1540@2|Bacteria,2GJA1@201174|Actinobacteria,4FE55@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the UPF0271 (lamB) family	ycsF	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
TLS3_k127_7772888_7	710696.Intca_0821	7.806e-80	273.0	COG2049@1|root,COG2049@2|Bacteria,2I2R8@201174|Actinobacteria,4FGPE@85021|Intrasporangiaceae	201174|Actinobacteria	E	Allophanate hydrolase subunit 1	kipI	-	-	-	-	-	-	-	-	-	-	-	CT_C_D
TLS3_k127_7772888_2	1385518.N798_07670	4.391e-107	356.0	COG1984@1|root,COG1984@2|Bacteria,2GITH@201174|Actinobacteria,4FGH8@85021|Intrasporangiaceae	201174|Actinobacteria	E	Allophanate hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CT_A_B,CT_C_D
TLS3_k127_7833213_1	1210046.B277_04282	0.0	1573.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4FE5A@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
TLS3_k127_7833213_19	367299.JOEE01000008_gene413	8.088e-147	477.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4FF3N@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
TLS3_k127_7833213_5	1210046.B277_04292	1.787e-316	993.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4FFMH@85021|Intrasporangiaceae	201174|Actinobacteria	E	DNA-binding protein	ydaO	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
TLS3_k127_7833213_41	367299.JOEE01000008_gene411	6.989e-97	344.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4FED5@85021|Intrasporangiaceae	201174|Actinobacteria	P	Potassium transporter TrkA	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS3_k127_7833213_36	367299.JOEE01000008_gene410	1.045e-105	360.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4FEXE@85021|Intrasporangiaceae	201174|Actinobacteria	P	Portal protein	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
TLS3_k127_7833213_47	1385520.N802_14410	3.857e-79	271.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4FGM6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
TLS3_k127_7833213_69	479431.Namu_3759	7.189e-16	84.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria,4ETC1@85013|Frankiales	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_52	367299.JOEE01000008_gene407	3.422e-68	242.0	28J4D@1|root,30NZ9@2|Bacteria,2I2E9@201174|Actinobacteria,4FGDW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3710)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3710
TLS3_k127_7833213_56	1210046.B277_04317	6.971e-50	183.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4FGNM@85021|Intrasporangiaceae	201174|Actinobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
TLS3_k127_7833213_55	1385521.N803_07200	3.545e-50	179.0	2ATJW@1|root,31J3Z@2|Bacteria,2IKN0@201174|Actinobacteria,4FGXK@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4193)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4193
TLS3_k127_7833213_42	1210046.B277_04327	7.68e-91	317.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4FGCP@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the inositol monophosphatase superfamily	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
TLS3_k127_7833213_21	1386089.N865_12555	1.211e-144	467.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4FEKH@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
TLS3_k127_7833213_43	313589.JNB_01780	2.005e-89	310.0	28PUQ@1|root,2ZCFK@2|Bacteria,2GNQM@201174|Actinobacteria,4FEVK@85021|Intrasporangiaceae	201174|Actinobacteria	S	DNA-binding protein	-	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	DUF3071
TLS3_k127_7833213_34	1385520.N802_14370	1.013e-109	359.0	COG1435@1|root,COG1435@2|Bacteria,2GP1W@201174|Actinobacteria,4FE4E@85021|Intrasporangiaceae	201174|Actinobacteria	F	thymidine kinase	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
TLS3_k127_7833213_26	1385520.N802_14365	5.73e-128	421.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,4FENE@85021|Intrasporangiaceae	201174|Actinobacteria	S	nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
TLS3_k127_7833213_51	1385519.N801_01190	7.19e-72	247.0	29850@1|root,2ZVAX@2|Bacteria,2GKR1@201174|Actinobacteria,4FFHI@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_4	1385518.N798_04650	0.0	1084.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,2GKN1@201174|Actinobacteria,4FEVV@85021|Intrasporangiaceae	201174|Actinobacteria	CJ	Multidrug ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
TLS3_k127_7833213_50	313589.JNB_01755	2.226e-72	254.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4FGAT@85021|Intrasporangiaceae	201174|Actinobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
TLS3_k127_7833213_2	367299.JOEE01000008_gene395	0.0	1236.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4FFIY@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA topoisomerase (ATP-hydrolyzing)	gyrA2	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
TLS3_k127_7833213_11	1123251.ATWM01000004_gene1894	6.871e-208	656.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria,4FG1W@85021|Intrasporangiaceae	201174|Actinobacteria	G	Sugar ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
TLS3_k127_7833213_22	1304865.JAGF01000001_gene1036	4.582e-140	452.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria,4F1Y8@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS3_k127_7833213_25	1713.JOFV01000006_gene2723	3.019e-129	435.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria,4F0UW@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
TLS3_k127_7833213_40	1385521.N803_07135	4.135e-102	345.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria,4FEZX@85021|Intrasporangiaceae	201174|Actinobacteria	K	Periplasmic binding protein-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
TLS3_k127_7833213_3	1385519.N801_01145	0.0	1154.0	COG0187@1|root,COG0187@2|Bacteria,2GM1E@201174|Actinobacteria,4FEA1@85021|Intrasporangiaceae	201174|Actinobacteria	L	DNA topoisomerase (ATP-hydrolyzing)	gyrB2	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
TLS3_k127_7833213_67	1193181.BN10_990006	5.732e-21	100.0	2E39Y@1|root,32Y9G@2|Bacteria,2GQJA@201174|Actinobacteria,4FHNQ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_60	313589.JNB_01710	4.522e-46	171.0	COG2839@1|root,COG2839@2|Bacteria,2IQDE@201174|Actinobacteria,4FH1V@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
TLS3_k127_7833213_66	1184609.KILIM_082_00070	6.047e-22	102.0	2E49S@1|root,32Z5G@2|Bacteria,2IHN1@201174|Actinobacteria,4F766@85018|Dermatophilaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
TLS3_k127_7833213_14	1193181.BN10_990003	8.21e-184	587.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4FE61@85021|Intrasporangiaceae	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
TLS3_k127_7833213_49	1385518.N798_04585	6.312e-77	272.0	COG2227@1|root,COG2227@2|Bacteria,2GMAR@201174|Actinobacteria,4FGBS@85021|Intrasporangiaceae	201174|Actinobacteria	H	Methyltransferase	smtA	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25
TLS3_k127_7833213_0	1385519.N801_16590	0.0	1597.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4FEK0@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
TLS3_k127_7833213_64	1123251.ATWM01000004_gene1916	9.205e-26	111.0	2CGM3@1|root,32S47@2|Bacteria,2GP7H@201174|Actinobacteria,4FHJA@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_71	110319.CF8_2690	5.232e-12	70.0	2ERD0@1|root,33IYN@2|Bacteria,2GXC0@201174|Actinobacteria,4DSVZ@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_10	1380347.JNII01000005_gene3086	2.119e-210	671.0	COG1982@1|root,COG1982@2|Bacteria,2GJ31@201174|Actinobacteria	201174|Actinobacteria	E	Orn Lys Arg decarboxylase	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
TLS3_k127_7833213_24	1385520.N802_09570	2.698e-129	431.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4FIAT@85021|Intrasporangiaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
TLS3_k127_7833213_58	1385520.N802_14260	6.959e-48	179.0	COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria,4FHAY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
TLS3_k127_7833213_20	1385519.N801_16610	2.519e-145	476.0	COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,4FG3Q@85021|Intrasporangiaceae	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
TLS3_k127_7833213_37	1385519.N801_16615	5.487e-103	360.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4FEN8@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
TLS3_k127_7833213_59	313589.JNB_01600	1.071e-47	175.0	2E0H9@1|root,32W34@2|Bacteria,2IHPW@201174|Actinobacteria,4FGU9@85021|Intrasporangiaceae	201174|Actinobacteria	S	transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010565,GO:0016310,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_45	1385519.N801_16625	1.49e-87	305.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2IBV1@201174|Actinobacteria,4FFV6@85021|Intrasporangiaceae	201174|Actinobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
TLS3_k127_7833213_13	367299.JOEE01000008_gene371	9.883e-193	621.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4FEAH@85021|Intrasporangiaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
TLS3_k127_7833213_30	1193181.BN10_360039	7.492e-117	389.0	COG0697@1|root,COG0697@2|Bacteria,2I8X5@201174|Actinobacteria,4FF8D@85021|Intrasporangiaceae	201174|Actinobacteria	EG	permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
TLS3_k127_7833213_15	367299.JOEE01000008_gene368	1.85e-162	517.0	COG2008@1|root,COG2008@2|Bacteria,2GMNV@201174|Actinobacteria,4FFGJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
TLS3_k127_7833213_8	1385521.N803_07030	3.982e-246	766.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4FFDT@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the class-II DAHP synthase family	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.5.1.54	ko:K01626,ko:K16019	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01051,map01100,map01110,map01130,map01230,map02024	M00022	R01826,R06591	RC00435,RC01556	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2178c	DAHP_synth_2
TLS3_k127_7833213_39	1385519.N801_09340	3.886e-102	337.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4FFSW@85021|Intrasporangiaceae	201174|Actinobacteria	K	LuxR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
TLS3_k127_7833213_35	367299.JOEE01000008_gene365	3.545e-107	361.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4FER4@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
TLS3_k127_7833213_31	1380370.JIBA01000013_gene1157	1.02e-116	380.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4FEIG@85021|Intrasporangiaceae	201174|Actinobacteria	I	1-acyl-sn-glycerol-3-phosphate acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
TLS3_k127_7833213_44	1386089.N865_19495	4.402e-88	304.0	COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria,4FJ0E@85021|Intrasporangiaceae	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
TLS3_k127_7833213_65	367299.JOEE01000008_gene363	2.547e-24	115.0	2EN8E@1|root,33FW7@2|Bacteria,2GSD4@201174|Actinobacteria,4FHSP@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_9	1184609.KILIM_029_00240	2.495e-228	716.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0004358,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00619,ko:K00930,ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226	AA_kinase,Acetyltransf_1
TLS3_k127_7833213_53	1385521.N803_07005	1.869e-67	237.0	COG3568@1|root,COG3568@2|Bacteria,2GMRU@201174|Actinobacteria,4FGNW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
TLS3_k127_7833213_18	710696.Intca_1972	2.2e-148	479.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4FE3J@85021|Intrasporangiaceae	201174|Actinobacteria	GK	glucokinase	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
TLS3_k127_7833213_73	1385521.N803_06995	0.0001392	50.0	2DSQS@1|root,33H36@2|Bacteria,2GZRE@201174|Actinobacteria,4FI6D@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_32	1385521.N803_06990	1.267e-113	379.0	COG0003@1|root,COG0003@2|Bacteria,2GISZ@201174|Actinobacteria,4FFQY@85021|Intrasporangiaceae	201174|Actinobacteria	P	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
TLS3_k127_7833213_62	1380370.JIBA01000013_gene1153	1.153e-40	155.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4FGJQ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
TLS3_k127_7833213_28	1385520.N802_14165	3.934e-120	400.0	2B0YS@1|root,31TBU@2|Bacteria,2I9Q5@201174|Actinobacteria,4FEVU@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_68	1121017.AUFG01000001_gene2976	1.111e-17	96.0	COG0308@1|root,COG0308@2|Bacteria,2GK29@201174|Actinobacteria,4FJZW@85021|Intrasporangiaceae	201174|Actinobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_74	1210046.B277_15539	0.0004768	49.0	29QCV@1|root,30BC3@2|Bacteria,2GVJ2@201174|Actinobacteria,4FHPP@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7833213_12	1385518.N798_08130	3.549e-199	640.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,4FEF6@85021|Intrasporangiaceae	201174|Actinobacteria	L	Contains 3'-5'exonuclease domain	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
TLS3_k127_7833213_63	1246448.ANAZ01000014_gene1517	8.457e-29	123.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,4EJZK@85012|Streptosporangiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
TLS3_k127_7833213_23	367299.JOEE01000004_gene1443	6.04e-133	436.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4FFAQ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
TLS3_k127_7833213_54	1386089.N865_14445	8.115e-54	205.0	COG0784@1|root,COG0784@2|Bacteria,2II71@201174|Actinobacteria,4FGT0@85021|Intrasporangiaceae	201174|Actinobacteria	T	Regulator	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Response_reg
TLS3_k127_7833213_33	1385520.N802_14120	1.892e-110	360.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4FE59@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
TLS3_k127_7833213_38	1385520.N802_14115	9.609e-103	341.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4FF7E@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cystathionine beta-lyase	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
TLS3_k127_7833213_16	1385520.N802_14110	4.964e-160	512.0	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4FE3Q@85021|Intrasporangiaceae	201174|Actinobacteria	C	Ubiquinol-cytochrome C reductase	qcrA	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
TLS3_k127_7833213_7	367299.JOEE01000004_gene1438	2.614e-278	864.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4FEM4@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome B subunit	qcrB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
TLS3_k127_7833213_70	1380356.JNIK01000019_gene338	1.541e-13	78.0	COG1872@1|root,COG1872@2|Bacteria,2GQSC@201174|Actinobacteria,4ETJW@85013|Frankiales	201174|Actinobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
TLS3_k127_7833213_57	1122622.ATWJ01000009_gene3211	2.999e-49	178.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4FH6J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
TLS3_k127_7833213_48	1122622.ATWJ01000015_gene596	3.041e-78	268.0	COG2258@1|root,COG2258@2|Bacteria,2GMCN@201174|Actinobacteria,4FGNE@85021|Intrasporangiaceae	201174|Actinobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
TLS3_k127_7833213_61	1385519.N801_09470	9.739e-46	169.0	2D9MJ@1|root,32TTI@2|Bacteria,2IFFM@201174|Actinobacteria,4FHVJ@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the cytochrome c oxidase bacterial subunit CtaF family	ctaF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cyt_c_ox_IV
TLS3_k127_7833213_6	1385519.N801_09475	4.101e-314	968.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4FF4D@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
TLS3_k127_7833213_27	1193181.BN10_360010	1.167e-122	402.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4FG8W@85021|Intrasporangiaceae	201174|Actinobacteria	C	Cytochrome c oxidase subunit	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
TLS3_k127_7833213_29	710696.Intca_1990	2.758e-118	396.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria,4FF85@85021|Intrasporangiaceae	201174|Actinobacteria	E	Aminotransferase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
TLS3_k127_7833213_72	656024.FsymDg_3195	7.293e-09	68.0	COG0425@1|root,COG0425@2|Bacteria,2GSF4@201174|Actinobacteria,4ETGP@85013|Frankiales	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
TLS3_k127_7833213_46	1121017.AUFG01000001_gene2961	1.534e-87	310.0	COG2360@1|root,COG2360@2|Bacteria,2IFT7@201174|Actinobacteria,4FFYP@85021|Intrasporangiaceae	201174|Actinobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
TLS3_k127_7833213_17	1172188.KB911827_gene4340	1.651e-159	508.0	COG0524@1|root,COG0524@2|Bacteria,2GKBG@201174|Actinobacteria,4FEMQ@85021|Intrasporangiaceae	201174|Actinobacteria	G	Ribokinase	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS3_k127_7834863_0	1385520.N802_10720	0.0	1391.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4FFX9@85021|Intrasporangiaceae	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
TLS3_k127_7834863_1	1385518.N798_13490	3.788e-193	616.0	COG0318@1|root,COG0318@2|Bacteria,2GKDF@201174|Actinobacteria,4FIQJ@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	acyl-CoA synthetase	fadD9	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,Polyketide_cyc2
TLS3_k127_7834863_3	1122622.ATWJ01000009_gene3386	3.729e-33	138.0	COG1413@1|root,COG1413@2|Bacteria,2GITU@201174|Actinobacteria,4FGE0@85021|Intrasporangiaceae	201174|Actinobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
TLS3_k127_7834863_2	644548.SCNU_13869	3.365e-99	330.0	COG0789@1|root,COG0789@2|Bacteria,2H5GI@201174|Actinobacteria,4GA4U@85026|Gordoniaceae	201174|Actinobacteria	K	TipAS antibiotic-recognition domain	tipA	-	-	ko:K21744	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1,TipAS
TLS3_k127_793227_9	1210046.B277_11310	3.062e-103	347.0	COG0328@1|root,COG0328@2|Bacteria,2I4IN@201174|Actinobacteria,4FF0E@85021|Intrasporangiaceae	201174|Actinobacteria	L	Reverse transcriptase-like	-	-	3.1.26.4,3.1.3.73	ko:K03469,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Glyoxalase_4,His_Phos_1,RVT_3
TLS3_k127_793227_2	1386089.N865_07750	1.923e-192	607.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4FEG7@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0391	Cys_Met_Meta_PP
TLS3_k127_793227_17	1122622.ATWJ01000011_gene2150	5.34e-24	109.0	296PW@1|root,2ZTZ1@2|Bacteria,2HC4M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_793227_10	1385519.N801_15495	1.429e-96	321.0	COG3022@1|root,COG3022@2|Bacteria,2GJPM@201174|Actinobacteria,4FFCQ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the UPF0246 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700	-	ko:K09861	-	-	-	-	ko00000	-	-	-	H2O2_YaaD
TLS3_k127_793227_12	110319.CF8_1599	2.925e-62	218.0	COG0655@1|root,COG0655@2|Bacteria,2II43@201174|Actinobacteria,4DQYB@85009|Propionibacteriales	201174|Actinobacteria	S	Multimeric flavodoxin WrbA	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
TLS3_k127_793227_4	1172188.KB911827_gene4180	1.301e-168	542.0	COG0557@1|root,COG0557@2|Bacteria,2GNSM@201174|Actinobacteria,4FEXZ@85021|Intrasporangiaceae	201174|Actinobacteria	K	ribonuclease II	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
TLS3_k127_793227_15	1380390.JIAT01000010_gene3978	3.958e-35	144.0	2DW5E@1|root,33YM7@2|Bacteria,2GSAI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_793227_14	710696.Intca_1861	2.849e-50	184.0	2E6U3@1|root,331DV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
TLS3_k127_793227_8	358823.DF19_08225	8.442e-125	412.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
TLS3_k127_793227_11	1193181.BN10_730010	1.909e-93	312.0	COG2220@1|root,COG2220@2|Bacteria,2GNHK@201174|Actinobacteria,4FGC4@85021|Intrasporangiaceae	201174|Actinobacteria	S	Zn-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
TLS3_k127_793227_19	1385518.N798_02655	9.866e-15	75.0	2DTTM@1|root,33MK2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_793227_6	367299.JOEE01000010_gene3320	1.239e-158	507.0	COG0024@1|root,COG0024@2|Bacteria,2GKIZ@201174|Actinobacteria,4FEY8@85021|Intrasporangiaceae	201174|Actinobacteria	E	Methionine aminopeptidase	map	GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
TLS3_k127_793227_18	1385519.N801_15525	1.263e-19	90.0	2EHMB@1|root,33BD3@2|Bacteria,2HXVR@201174|Actinobacteria,4FHZ8@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_793227_1	1386089.N865_15910	1.505e-212	669.0	COG2403@1|root,COG2403@2|Bacteria,2IF9H@201174|Actinobacteria,4FEFF@85021|Intrasporangiaceae	201174|Actinobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_793227_13	367299.JOEE01000010_gene3318	4.328e-57	213.0	COG2227@1|root,COG2227@2|Bacteria,2I2JZ@201174|Actinobacteria,4FHJW@85021|Intrasporangiaceae	201174|Actinobacteria	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
TLS3_k127_793227_7	1385520.N802_00160	3.526e-155	507.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4FFPI@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
TLS3_k127_793227_3	1120954.ATXE01000001_gene1488	1.094e-181	589.0	COG0438@1|root,COG2120@1|root,COG0438@2|Bacteria,COG2120@2|Bacteria,2GJ57@201174|Actinobacteria,4DN29@85009|Propionibacteriales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_793227_0	1385518.N798_02625	3.656e-264	816.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4FF3Q@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the glutamine synthetase family	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
TLS3_k127_793227_5	1193181.BN10_730002	2.707e-165	537.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4FF2Y@85021|Intrasporangiaceae	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
TLS3_k127_7958806_6	1380370.JIBA01000015_gene377	9.952e-165	539.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4FFEC@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS3_k127_7958806_16	367299.JOEE01000004_gene1080	7.124e-49	179.0	COG1846@1|root,COG1846@2|Bacteria,2GUZX@201174|Actinobacteria,4FH71@85021|Intrasporangiaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
TLS3_k127_7958806_14	1122622.ATWJ01000013_gene85	3.071e-52	188.0	COG3801@1|root,COG3801@2|Bacteria,2IHP4@201174|Actinobacteria,4FHTR@85021|Intrasporangiaceae	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
TLS3_k127_7958806_12	1122622.ATWJ01000001_gene2484	4.303e-70	249.0	COG1309@1|root,COG1309@2|Bacteria,2HG87@201174|Actinobacteria,4FGIS@85021|Intrasporangiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
TLS3_k127_7958806_0	1043205.AFYF01000011_gene1425	0.0	1058.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4FF15@85021|Intrasporangiaceae	201174|Actinobacteria	S	of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
TLS3_k127_7958806_11	1122622.ATWJ01000015_gene537	4.427e-73	250.0	COG2323@1|root,COG2323@2|Bacteria,2IIPT@201174|Actinobacteria,4FI3R@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
TLS3_k127_7958806_19	367299.JOEE01000004_gene1123	1.383e-06	55.0	COG5395@1|root,COG5395@2|Bacteria,2IHVI@201174|Actinobacteria,4FGM7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2306
TLS3_k127_7958806_13	58123.JOFJ01000033_gene67	1.641e-69	247.0	2A1WW@1|root,30Q6B@2|Bacteria,2HGNT@201174|Actinobacteria,4EKVI@85012|Streptosporangiales	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
TLS3_k127_7958806_8	1172188.KB911820_gene2531	1.043e-153	495.0	COG1940@1|root,COG1940@2|Bacteria,2GJ2S@201174|Actinobacteria,4FE47@85021|Intrasporangiaceae	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HTH_24,ROK
TLS3_k127_7958806_2	313589.JNB_10364	1.643e-228	717.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4FFVT@85021|Intrasporangiaceae	201174|Actinobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
TLS3_k127_7958806_7	1385518.N798_02070	1.183e-156	508.0	COG1172@1|root,COG1172@2|Bacteria,2GJDW@201174|Actinobacteria,4FEAN@85021|Intrasporangiaceae	201174|Actinobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
TLS3_k127_7958806_5	1380370.JIBA01000012_gene3518	7.517e-165	526.0	COG1879@1|root,COG1879@2|Bacteria,2GJ0Z@201174|Actinobacteria,4FE7I@85021|Intrasporangiaceae	201174|Actinobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
TLS3_k127_7958806_4	1385518.N798_02060	2.009e-181	576.0	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria,4FEVC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
TLS3_k127_7958806_3	1385518.N798_02050	8.951e-205	649.0	COG1082@1|root,COG1082@2|Bacteria,2GK1S@201174|Actinobacteria,4FFWF@85021|Intrasporangiaceae	201174|Actinobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
TLS3_k127_7958806_18	1437606.BBOH_1007	7.114e-13	70.0	COG1070@1|root,COG1070@2|Bacteria,2GJDZ@201174|Actinobacteria,4CZH0@85004|Bifidobacteriales	201174|Actinobacteria	G	FGGY family of carbohydrate kinases, C-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
TLS3_k127_7958806_17	42256.RradSPS_2195	1.047e-23	110.0	29DTG@1|root,300RC@2|Bacteria,2HCYB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7958806_15	930171.Asphe3_09780	4.008e-49	196.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria,1W9ZI@1268|Micrococcaceae	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
TLS3_k127_7958806_1	1043205.AFYF01000044_gene2930	0.0	1054.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4FEX9@85021|Intrasporangiaceae	201174|Actinobacteria	L	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
TLS3_k127_7958806_20	268407.PWYN_09845	0.0007422	51.0	2CH44@1|root,32S57@2|Bacteria,1VCKH@1239|Firmicutes,4HKXX@91061|Bacilli,26XPU@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_7958806_9	1211815.CBYP010000066_gene1588	8.195e-118	384.0	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria,4ESUU@85013|Frankiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
TLS3_k127_7958806_10	1906.SFRA_24355	9.929e-95	314.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria	201174|Actinobacteria	F	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
TLS3_k127_8026859_6	367299.JOEE01000003_gene3067	1.45e-163	517.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FEZI@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_8026859_11	313589.JNB_18208	8.818e-126	416.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria,4FFE6@85021|Intrasporangiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
TLS3_k127_8026859_9	1193181.BN10_110002	1.191e-142	458.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4FEZQ@85021|Intrasporangiaceae	201174|Actinobacteria	L	uracil-DNA glycosylase	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
TLS3_k127_8026859_13	1385521.N803_06540	2.069e-75	259.0	COG0572@1|root,COG0572@2|Bacteria,2GM18@201174|Actinobacteria,4FGFB@85021|Intrasporangiaceae	201174|Actinobacteria	F	ATP-binding protein	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
TLS3_k127_8026859_3	1385520.N802_10350	1.623e-182	581.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4FEWW@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
TLS3_k127_8026859_16	1210046.B277_09127	1.381e-54	193.0	COG0662@1|root,COG0662@2|Bacteria,2IMHT@201174|Actinobacteria,4FGTT@85021|Intrasporangiaceae	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,EutQ
TLS3_k127_8026859_7	1193181.BN10_500008	2.097e-158	502.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4FFH3@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
TLS3_k127_8026859_2	710696.Intca_1216	2.425e-222	696.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4FETB@85021|Intrasporangiaceae	201174|Actinobacteria	F	pyrimidine-nucleoside phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
TLS3_k127_8026859_14	1121017.AUFG01000026_gene273	5.292e-64	222.0	COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria,4FGKS@85021|Intrasporangiaceae	201174|Actinobacteria	F	cytidine deaminase	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
TLS3_k127_8026859_4	1385520.N802_05345	2.835e-179	580.0	COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,4FGA1@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_8026859_8	1386089.N865_02910	2.965e-146	498.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4FERA@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
TLS3_k127_8026859_1	1385520.N802_05355	7.818e-258	804.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4FE5I@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
TLS3_k127_8026859_10	710696.Intca_1211	5.337e-137	456.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4FG7H@85021|Intrasporangiaceae	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
TLS3_k127_8026859_5	1193181.BN10_1680002	4.068e-164	530.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4FEVE@85021|Intrasporangiaceae	201174|Actinobacteria	S	amidohydrolase	amiA	-	-	ko:K01436,ko:K06048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
TLS3_k127_8026859_0	1386089.N865_02950	8.797e-289	906.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4FK0I@85021|Intrasporangiaceae	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
TLS3_k127_8026859_17	1122609.AUGT01000013_gene4213	4.779e-45	188.0	COG0615@1|root,COG0615@2|Bacteria	2|Bacteria	H	ADP-L-glycero-beta-D-manno-heptose biosynthetic process	-	-	2.7.7.39	ko:K00980	ko00564,map00564	-	R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
TLS3_k127_8026859_15	1048339.KB913029_gene2836	9.072e-64	227.0	COG1514@1|root,COG1514@2|Bacteria,2GRF0@201174|Actinobacteria,4ESTP@85013|Frankiales	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
TLS3_k127_8026859_12	367299.JOEE01000007_gene16	3.508e-125	404.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4FFI2@85021|Intrasporangiaceae	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
TLS3_k127_8049194_10	1385518.N798_02170	7.365e-17	81.0	2DTHU@1|root,33KEC@2|Bacteria,2HXVM@201174|Actinobacteria,4FHYE@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8049194_5	1089455.MOPEL_135_02250	3.306e-60	211.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4F741@85018|Dermatophilaceae	201174|Actinobacteria	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
TLS3_k127_8049194_4	367299.JOEE01000001_gene1787	2.983e-113	367.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria,4FF52@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
TLS3_k127_8049194_2	1385519.N801_14660	1.867e-168	534.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4FFKX@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone	fgd	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0019725,GO:0030312,GO:0031406,GO:0036094,GO:0042592,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046983,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363	1.1.98.2	ko:K15510	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
TLS3_k127_8049194_3	1306174.JODP01000004_gene1071	2.487e-124	407.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	Amacr	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
TLS3_k127_8049194_9	426117.M446_2906	1.848e-36	153.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2TQRV@28211|Alphaproteobacteria,1JTYK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
TLS3_k127_8049194_11	1210046.B277_10074	1.605e-14	83.0	2ED0J@1|root,336XJ@2|Bacteria,2I7ZH@201174|Actinobacteria,4FGMA@85021|Intrasporangiaceae	201174|Actinobacteria	S	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
TLS3_k127_8049194_7	471853.Bcav_0534	1.417e-45	166.0	COG5450@1|root,32SQA@2|Bacteria,2IKJX@201174|Actinobacteria	201174|Actinobacteria	K	Transcription regulator of the Arc MetJ class	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8049194_1	1193181.BN10_600006	1.047e-250	790.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4FERS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
TLS3_k127_8049194_6	367299.JOEE01000001_gene1795	8.691e-53	189.0	2DQ01@1|root,32UN7@2|Bacteria,2IS50@201174|Actinobacteria,4FGRQ@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8049194_0	1193181.BN10_600010	0.0	1081.0	COG0365@1|root,COG0365@2|Bacteria,2GP7N@201174|Actinobacteria,4FEXP@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acetyl-coenzyme A synthetase N-terminus	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
TLS3_k127_8049194_8	1380370.JIBA01000006_gene3382	1.753e-40	162.0	2DMKG@1|root,32S6P@2|Bacteria,2I57N@201174|Actinobacteria,4FK0Z@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF3817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3817
TLS3_k127_8049194_13	1120960.ATXG01000017_gene1459	7.484e-05	49.0	COG2247@1|root,COG2247@2|Bacteria	2|Bacteria	M	cell wall organization	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CW_binding_2,Peptidase_S8
TLS3_k127_8049194_14	710696.Intca_0275	0.0001193	46.0	COG2247@1|root,COG2247@2|Bacteria,2I4K0@201174|Actinobacteria,4FGIA@85021|Intrasporangiaceae	201174|Actinobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CW_binding_2,VCBS
TLS3_k127_8055923_7	710696.Intca_1614	2.729e-68	238.0	COG3268@1|root,COG3268@2|Bacteria,2GNGH@201174|Actinobacteria,4FFCY@85021|Intrasporangiaceae	201174|Actinobacteria	S	Enoyl reductase	LYS1	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030312,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K12445	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	Sacchrp_dh_NADP
TLS3_k127_8055923_8	1386089.N865_05955	2.003e-49	181.0	COG3467@1|root,COG3467@2|Bacteria,2IP5U@201174|Actinobacteria,4FGWT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
TLS3_k127_8055923_6	2045.KR76_19050	4.202e-81	290.0	COG1716@1|root,COG1716@2|Bacteria,2GK5I@201174|Actinobacteria,4DQB8@85009|Propionibacteriales	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
TLS3_k127_8055923_1	313589.JNB_12983	9.923e-195	620.0	COG2304@1|root,COG2304@2|Bacteria,2GMWM@201174|Actinobacteria,4FF26@85021|Intrasporangiaceae	201174|Actinobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2,VWA_3
TLS3_k127_8055923_4	935866.JAER01000003_gene1178	6.534e-108	370.0	COG0631@1|root,COG0631@2|Bacteria,2GKDM@201174|Actinobacteria,4DN5I@85009|Propionibacteriales	201174|Actinobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	prpB10	-	-	-	-	-	-	-	-	-	-	-	DZR,PP2C_2
TLS3_k127_8055923_0	2045.KR76_19065	6.161e-320	1012.0	COG0515@1|root,COG0515@2|Bacteria,2GJ24@201174|Actinobacteria,4DPBP@85009|Propionibacteriales	201174|Actinobacteria	KLT	Protein kinase G tetratricopeptide repeat	pknG	-	2.7.11.1	ko:K14949	ko05152,map05152	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	Pkinase,PknG_TPR,PknG_rubred
TLS3_k127_8055923_3	2045.KR76_19070	1.312e-113	381.0	28JK9@1|root,2Z9D5@2|Bacteria,2IAMP@201174|Actinobacteria,4DQ38@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8055923_2	1193181.BN10_1130013	3.636e-118	392.0	COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria,4FEKU@85021|Intrasporangiaceae	201174|Actinobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	glnH	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
TLS3_k127_8055923_5	313589.JNB_13008	7.114e-88	304.0	COG5278@1|root,COG5278@2|Bacteria,2GJ1Q@201174|Actinobacteria,4FG3T@85021|Intrasporangiaceae	201174|Actinobacteria	T	phosphoserine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8092026_0	1385518.N798_06855	4.104e-296	917.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4FEPT@85021|Intrasporangiaceae	201174|Actinobacteria	L	Type III restriction enzyme, res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
TLS3_k127_8092026_4	357808.RoseRS_4210	1.964e-16	94.0	COG5485@1|root,COG5485@2|Bacteria,2G7DA@200795|Chloroflexi,377RA@32061|Chloroflexia	32061|Chloroflexia	P	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
TLS3_k127_8092026_2	1121017.AUFG01000008_gene1429	6.389e-72	257.0	2AUNZ@1|root,31KBW@2|Bacteria,2GP4I@201174|Actinobacteria,4FG87@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2786
TLS3_k127_8092026_3	1386089.N865_12110	4.609e-65	227.0	COG1522@1|root,COG1522@2|Bacteria,2H7NM@201174|Actinobacteria,4FGJD@85021|Intrasporangiaceae	201174|Actinobacteria	K	AsnC family transcriptional regulator	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
TLS3_k127_8092026_1	367299.JOEE01000003_gene2880	6.831e-232	722.0	COG3185@1|root,COG3185@2|Bacteria,2GNF0@201174|Actinobacteria,4FEYX@85021|Intrasporangiaceae	201174|Actinobacteria	E	4-hydroxyphenylpyruvate dioxygenase	hpd	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
TLS3_k127_8143161_9	1193181.BN10_550001	8.554e-115	372.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4FFG8@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
TLS3_k127_8143161_23	1385520.N802_16985	8.879e-28	123.0	COG1357@1|root,COG1357@2|Bacteria,2I8N2@201174|Actinobacteria,4FI01@85021|Intrasporangiaceae	201174|Actinobacteria	S	Pentapeptide repeats (9 copies)	mfpA	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
TLS3_k127_8143161_11	1043205.AFYF01000026_gene440	4.753e-105	346.0	COG1183@1|root,COG1183@2|Bacteria,2IC3M@201174|Actinobacteria	201174|Actinobacteria	I	phosphatidylcholine synthase	pcs	-	2.7.8.24	ko:K01004	ko00564,ko01110,map00564,map01110	-	R05794	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
TLS3_k127_8143161_20	446470.Snas_2600	4.14e-40	150.0	COG0140@1|root,COG0140@2|Bacteria,2IQ4D@201174|Actinobacteria,4EYV0@85014|Glycomycetales	201174|Actinobacteria	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0044403,GO:0044419,GO:0044464,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0071944,GO:0075136,GO:0075139	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
TLS3_k127_8143161_6	1193181.BN10_860003	6.249e-142	459.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4FEII@85021|Intrasporangiaceae	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
TLS3_k127_8143161_22	1386089.N865_00825	1.922e-33	145.0	2E71H@1|root,331K6@2|Bacteria,2I18I@201174|Actinobacteria,4FHM5@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
TLS3_k127_8143161_15	367299.JOEE01000005_gene3499	1.117e-68	256.0	COG0572@1|root,COG0572@2|Bacteria,2HQC8@201174|Actinobacteria,4FGFG@85021|Intrasporangiaceae	201174|Actinobacteria	F	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,Cytidylate_kin
TLS3_k127_8143161_8	1193181.BN10_860006	3.097e-126	408.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4FE4T@85021|Intrasporangiaceae	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
TLS3_k127_8143161_19	446466.Cfla_1993	6.52e-48	175.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4F2HH@85016|Cellulomonadaceae	201174|Actinobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1606	PRA-CH
TLS3_k127_8143161_2	1385518.N798_15095	1.452e-253	792.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4FE6P@85021|Intrasporangiaceae	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
TLS3_k127_8143161_24	367299.JOEE01000005_gene3508	9.543e-25	112.0	2EGC7@1|root,33A40@2|Bacteria,2HXV4@201174|Actinobacteria,4FHTW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Tryptophan-associated transmembrane protein (Trp_oprn_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Trp_oprn_chp
TLS3_k127_8143161_14	1210046.B277_11850	1.867e-85	305.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4FFW9@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
TLS3_k127_8143161_4	367299.JOEE01000005_gene3511	4.929e-219	694.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4FF8X@85021|Intrasporangiaceae	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
TLS3_k127_8143161_10	1193181.BN10_860014	4.369e-107	358.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4FEEI@85021|Intrasporangiaceae	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
TLS3_k127_8143161_18	1385518.N798_14430	7.039e-49	184.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria,4FHCV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
TLS3_k127_8143161_16	313589.JNB_03830	2.895e-58	215.0	COG1651@1|root,COG1651@2|Bacteria,2GKH8@201174|Actinobacteria,4FGR1@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
TLS3_k127_8143161_7	1385519.N801_11135	1.55e-135	436.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4FFGE@85021|Intrasporangiaceae	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
TLS3_k127_8143161_0	1306174.JODP01000013_gene7460	0.0	2317.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria	201174|Actinobacteria	E	Glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
TLS3_k127_8143161_3	1121017.AUFG01000004_gene3229	2.77e-251	788.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4FECB@85021|Intrasporangiaceae	201174|Actinobacteria	E	provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
TLS3_k127_8143161_5	367299.JOEE01000005_gene3518	2.519e-210	662.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4FEJM@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the formation of phosphoenolpyruvate from pyruvate	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS3_k127_8143161_25	1210046.B277_11890	1.992e-05	49.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4FEJM@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the formation of phosphoenolpyruvate from pyruvate	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
TLS3_k127_8143161_13	313589.JNB_03795	1.771e-88	316.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4FERE@85021|Intrasporangiaceae	201174|Actinobacteria	T	Regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
TLS3_k127_8143161_12	1385518.N798_14470	6.158e-101	336.0	COG1811@1|root,COG1811@2|Bacteria,2GM75@201174|Actinobacteria,4FESJ@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
TLS3_k127_8143161_21	1385519.N801_11175	1.586e-38	151.0	COG0454@1|root,COG0456@2|Bacteria,2II5Y@201174|Actinobacteria,4FGGR@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
TLS3_k127_8143161_17	1122622.ATWJ01000010_gene1379	1.237e-49	199.0	COG2050@1|root,COG2050@2|Bacteria,2IKTU@201174|Actinobacteria,4FGPR@85021|Intrasporangiaceae	201174|Actinobacteria	Q	protein possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_8143161_1	1385521.N803_08825	0.0	1334.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4FEBK@85021|Intrasporangiaceae	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
TLS3_k127_8266993_8	313589.JNB_20438	2.528e-48	176.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4FGXF@85021|Intrasporangiaceae	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
TLS3_k127_8266993_10	675635.Psed_1989	1.188e-39	154.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4E5NQ@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
TLS3_k127_8266993_0	367299.JOEE01000004_gene1269	2.466e-271	841.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4FFD9@85021|Intrasporangiaceae	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
TLS3_k127_8266993_2	367299.JOEE01000004_gene1270	2.822e-161	519.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4FEX0@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
TLS3_k127_8266993_3	367299.JOEE01000004_gene1271	2.179e-148	497.0	COG2240@1|root,COG2240@2|Bacteria,2HS59@201174|Actinobacteria,4FF4R@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the pyridoxine kinase family	pdxY	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
TLS3_k127_8266993_1	367299.JOEE01000004_gene1272	1.032e-190	605.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4FER5@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2427c	Aldedh
TLS3_k127_8266993_12	367299.JOEE01000004_gene1274	4.36e-06	52.0	2B3QY@1|root,31WEH@2|Bacteria,2HXVT@201174|Actinobacteria,4FHZV@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8266993_4	1385520.N802_10045	1.801e-102	338.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4FF49@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
TLS3_k127_8266993_7	1385521.N803_06070	1.51e-49	181.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4FGS2@85021|Intrasporangiaceae	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
TLS3_k127_8266993_6	1385520.N802_10035	5.255e-53	199.0	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4FH6Q@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the phosphoglycerate mutase family	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
TLS3_k127_8266993_11	1288083.AUKR01000009_gene1877	7.176e-07	53.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
TLS3_k127_8266993_9	1193181.BN10_930005	6.496e-40	157.0	COG3714@1|root,COG3714@2|Bacteria,2IG79@201174|Actinobacteria,4FGG0@85021|Intrasporangiaceae	201174|Actinobacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
TLS3_k127_8266993_5	367299.JOEE01000004_gene1287	1.354e-94	313.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4FEMM@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
TLS3_k127_8304169_6	1193181.BN10_920033	4.005e-117	384.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria,4FFKN@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
TLS3_k127_8304169_12	367299.JOEE01000007_gene169	6.988e-09	68.0	29AMS@1|root,2ZXMN@2|Bacteria,2GXZW@201174|Actinobacteria,4FI34@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8304169_4	367299.JOEE01000007_gene168	2.487e-173	546.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FFIM@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_8304169_8	367299.JOEE01000007_gene168	1.73e-40	153.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FFIM@85021|Intrasporangiaceae	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
TLS3_k127_8304169_5	1385519.N801_16355	1.109e-136	445.0	COG2755@1|root,COG2755@2|Bacteria,2GMVS@201174|Actinobacteria,4FF0T@85021|Intrasporangiaceae	201174|Actinobacteria	E	G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
TLS3_k127_8304169_2	1121017.AUFG01000001_gene3107	8.976e-245	767.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria,4FFS8@85021|Intrasporangiaceae	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	tlrC	-	-	ko:K18230	ko02010,map02010	-	-	-	ko00000,ko00001,ko01504,ko02000	3.A.1.120	-	-	ABC_tran,ABC_tran_Xtn
TLS3_k127_8304169_7	1408452.JAGZ01000006_gene686	8.766e-108	367.0	COG1403@1|root,COG1403@2|Bacteria,2I9AH@201174|Actinobacteria,232HK@1762|Mycobacteriaceae	201174|Actinobacteria	V	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
TLS3_k127_8304169_9	1033802.SSPSH_001694	6.355e-37	153.0	COG1020@1|root,COG1020@2|Bacteria,1MY7C@1224|Proteobacteria,1S8PP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8304169_10	110319.CF8_1385	5.833e-31	127.0	COG5496@1|root,COG5496@2|Bacteria,2IKZP@201174|Actinobacteria,4DRX7@85009|Propionibacteriales	201174|Actinobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
TLS3_k127_8304169_1	1033730.CAHG01000012_gene2216	1.405e-247	773.0	COG4799@1|root,COG4799@2|Bacteria,2I46V@201174|Actinobacteria,4DP3F@85009|Propionibacteriales	201174|Actinobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl,Carboxyl_trans
TLS3_k127_8304169_0	1292020.H483_0100925	4.835e-308	952.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
TLS3_k127_8304169_3	1385519.N801_16360	1.136e-237	740.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2GIXE@201174|Actinobacteria,4FEFP@85021|Intrasporangiaceae	201174|Actinobacteria	EK	Cystathionine beta-synthase	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
TLS3_k127_8337654_0	526225.Gobs_1707	4.914e-210	665.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria,4ES9G@85013|Frankiales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
TLS3_k127_8337654_4	1210046.B277_08584	2.656e-31	141.0	COG1393@1|root,COG1393@2|Bacteria,2HXIK@201174|Actinobacteria,4FH1M@85021|Intrasporangiaceae	201174|Actinobacteria	P	ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
TLS3_k127_8337654_3	1123251.ATWM01000003_gene951	2.097e-77	265.0	COG0300@1|root,COG0300@2|Bacteria,2HJGE@201174|Actinobacteria,4FGMX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
TLS3_k127_8337654_2	1193181.BN10_1060021	2.901e-97	331.0	COG0477@1|root,COG2814@2|Bacteria,2GK22@201174|Actinobacteria,4FEEC@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
TLS3_k127_8337654_1	367299.JOEE01000010_gene3298	5.562e-101	340.0	COG0642@1|root,COG2205@2|Bacteria,2GMB9@201174|Actinobacteria,4FE99@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
TLS3_k127_8457150_11	1120960.ATXG01000001_gene1075	1.162e-132	444.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4FMB6@85023|Microbacteriaceae	201174|Actinobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
TLS3_k127_8457150_13	1120960.ATXG01000001_gene1076	8.188e-120	411.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4FNB3@85023|Microbacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
TLS3_k127_8457150_9	1120960.ATXG01000001_gene1077	4.073e-137	444.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4FP6E@85023|Microbacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
TLS3_k127_8457150_5	1120960.ATXG01000001_gene1078	8.529e-188	593.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4FNX3@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055,ko:K11069	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	SBP_bac_8,TAT_signal
TLS3_k127_8457150_10	1151122.AQYD01000006_gene1704	8.635e-137	451.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4FKHX@85023|Microbacteriaceae	201174|Actinobacteria	E	TOBE domain	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
TLS3_k127_8457150_8	367299.JOEE01000011_gene3157	4.45e-140	458.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4FF10@85021|Intrasporangiaceae	201174|Actinobacteria	S	DNA polymerase V	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
TLS3_k127_8457150_4	1385520.N802_07730	2.282e-191	602.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4FE6R@85021|Intrasporangiaceae	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
TLS3_k127_8457150_7	1122622.ATWJ01000013_gene245	1.846e-141	463.0	COG4637@1|root,COG4637@2|Bacteria,2GQVV@201174|Actinobacteria,4FE42@85021|Intrasporangiaceae	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
TLS3_k127_8457150_6	1193181.BN10_130057	3.566e-156	524.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4FESU@85021|Intrasporangiaceae	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
TLS3_k127_8457150_26	1121017.AUFG01000003_gene3307	1.281e-19	93.0	COG1722@1|root,COG1722@2|Bacteria,2GR0U@201174|Actinobacteria,4FHFV@85021|Intrasporangiaceae	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
TLS3_k127_8457150_25	1385518.N798_06220	1.194e-45	172.0	2EID2@1|root,33C4E@2|Bacteria,2IH8P@201174|Actinobacteria,4FGUT@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4245)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4245
TLS3_k127_8457150_19	1385519.N801_05755	1.103e-87	299.0	COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,4FEAP@85021|Intrasporangiaceae	201174|Actinobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
TLS3_k127_8457150_1	1385518.N798_06205	5e-324	997.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,2GK6D@201174|Actinobacteria,4FF28@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
TLS3_k127_8457150_24	1193181.BN10_130064	1.04e-70	256.0	COG0288@1|root,COG0288@2|Bacteria,2GT5H@201174|Actinobacteria,4FJ0S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Carbonic anhydrase	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
TLS3_k127_8457150_18	367299.JOEE01000011_gene3145	4.631e-93	315.0	COG3217@1|root,COG3217@2|Bacteria,2GPWY@201174|Actinobacteria,4FGD3@85021|Intrasporangiaceae	201174|Actinobacteria	S	MOSC N-terminal beta barrel domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
TLS3_k127_8457150_14	285514.JNWO01000001_gene4257	3.555e-113	372.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0375c	CO_deh_flav_C,FAD_binding_5
TLS3_k127_8457150_20	1120949.KB903358_gene5201	1.823e-84	283.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4DCVY@85008|Micromonosporales	201174|Actinobacteria	C	[2Fe-2S] binding domain	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
TLS3_k127_8457150_0	543632.JOJL01000004_gene3969	0.0	1389.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DACC@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	coxL	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
TLS3_k127_8457150_17	1306990.BARG01000024_gene2601	3.235e-93	325.0	COG1975@1|root,COG1975@2|Bacteria,2IA9U@201174|Actinobacteria	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
TLS3_k127_8457150_12	1123321.KB905814_gene1695	2.801e-124	407.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria	201174|Actinobacteria	O	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
TLS3_k127_8457150_16	1306174.JODP01000008_gene2791	9.644e-104	350.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria	201174|Actinobacteria	M	Protein containing von Willebrand factor type A (VWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
TLS3_k127_8457150_15	1246995.AFR_27170	1.449e-112	371.0	COG0583@1|root,COG0583@2|Bacteria,2I8WJ@201174|Actinobacteria,4DC8H@85008|Micromonosporales	201174|Actinobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
TLS3_k127_8457150_23	1193181.BN10_1320005	3.006e-76	259.0	COG2077@1|root,COG2077@2|Bacteria,2II20@201174|Actinobacteria,4FGNZ@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
TLS3_k127_8457150_2	313589.JNB_08014	3.021e-231	722.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4FE4U@85021|Intrasporangiaceae	201174|Actinobacteria	G	Beta-glucosidase	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
TLS3_k127_8457150_3	1193181.BN10_130071	4.089e-225	704.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4FECR@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
TLS3_k127_8457150_21	1385521.N803_03260	1.621e-82	282.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4FFWX@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
TLS3_k127_8457150_22	367299.JOEE01000011_gene3139	1.484e-81	274.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4FGEI@85021|Intrasporangiaceae	201174|Actinobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
TLS3_k127_8461294_1	312284.A20C1_10089	3.842e-105	348.0	COG1653@1|root,COG1653@2|Bacteria,2GJIP@201174|Actinobacteria	201174|Actinobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K10240	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	SBP_bac_8
TLS3_k127_8461294_0	446466.Cfla_0578	3.264e-320	1018.0	28HKI@1|root,2Z7VC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8461294_2	1317124.DW2_18294	2.111e-64	241.0	COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,2TVA6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Ferric reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
TLS3_k127_8461294_3	1125863.JAFN01000001_gene2355	1.294e-34	145.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,1PFJ7@1224|Proteobacteria,42WVE@68525|delta/epsilon subdivisions	1224|Proteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8480081_11	1385518.N798_09385	2.774e-20	106.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
TLS3_k127_8480081_3	1385519.N801_18680	1.04e-172	558.0	COG0438@1|root,COG0438@2|Bacteria,2HEX9@201174|Actinobacteria,4FFWE@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
TLS3_k127_8480081_4	1385519.N801_18685	5.775e-143	466.0	COG0392@1|root,COG0392@2|Bacteria,2ICMJ@201174|Actinobacteria,4FF3J@85021|Intrasporangiaceae	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
TLS3_k127_8480081_5	1184609.KILIM_065_00250	1.501e-108	357.0	COG3442@1|root,COG3442@2|Bacteria,2GKPV@201174|Actinobacteria,4F640@85018|Dermatophilaceae	201174|Actinobacteria	S	CobB/CobQ-like glutamine amidotransferase domain	cobQ2	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
TLS3_k127_8480081_2	367299.JOEE01000007_gene91	4.096e-193	610.0	COG0770@1|root,COG0770@2|Bacteria,2I2EU@201174|Actinobacteria,4FFSA@85021|Intrasporangiaceae	201174|Actinobacteria	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
TLS3_k127_8480081_6	1386089.N865_20480	3.569e-81	285.0	COG2815@1|root,COG2815@2|Bacteria	2|Bacteria	G	serine threonine protein kinase	-	-	2.7.11.1,3.4.16.4	ko:K03587,ko:K08884,ko:K12132	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01011,ko03036	-	-	-	PASTA
TLS3_k127_8480081_7	479432.Sros_3707	1.946e-52	205.0	COG1226@1|root,COG1226@2|Bacteria,2I8YK@201174|Actinobacteria,4EPYX@85012|Streptosporangiales	201174|Actinobacteria	P	RyR domain	-	-	-	-	-	-	-	-	-	-	-	-	RyR,TrkA_N
TLS3_k127_8480081_1	926550.CLDAP_13750	4.746e-261	840.0	COG1404@1|root,COG1404@2|Bacteria,2G7GP@200795|Chloroflexi	200795|Chloroflexi	M	LPXTG-motif cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
TLS3_k127_8480081_9	1121017.AUFG01000010_gene1640	1.467e-46	179.0	2DKZU@1|root,311IQ@2|Bacteria,2HY1Q@201174|Actinobacteria,4FJDE@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_8480081_0	1385521.N803_13160	1.039e-294	909.0	COG0519@1|root,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4FFHS@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
TLS3_k127_8480081_10	1210046.B277_01604	3.215e-38	150.0	2E65S@1|root,330UF@2|Bacteria,2IMEQ@201174|Actinobacteria,4FH46@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF3817)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3817
TLS3_k127_8480081_8	1380370.JIBA01000016_gene766	3.106e-50	187.0	COG3346@1|root,COG3346@2|Bacteria,2GMGB@201174|Actinobacteria,4FGIW@85021|Intrasporangiaceae	201174|Actinobacteria	S	SURF1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
TLS3_k127_879947_12	1122622.ATWJ01000007_gene1888	2.363e-35	138.0	COG1609@1|root,COG1609@2|Bacteria,2GMUU@201174|Actinobacteria,4FG75@85021|Intrasporangiaceae	201174|Actinobacteria	K	lacI family	-	-	-	ko:K02529,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
TLS3_k127_879947_3	1122622.ATWJ01000007_gene1889	3.747e-219	689.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria,4FFBW@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
TLS3_k127_879947_9	1122933.JNIY01000003_gene201	5.319e-107	368.0	COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria	201174|Actinobacteria	G	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
TLS3_k127_879947_11	1121933.AUHH01000037_gene1498	3.852e-47	180.0	COG1102@1|root,COG1102@2|Bacteria,2I8J3@201174|Actinobacteria	201174|Actinobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
TLS3_k127_879947_2	1120954.ATXE01000003_gene609	6.495e-233	729.0	COG1904@1|root,COG1904@2|Bacteria,2I8PE@201174|Actinobacteria,4DQ45@85009|Propionibacteriales	201174|Actinobacteria	G	Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
TLS3_k127_879947_5	1120954.ATXE01000001_gene2208	3.447e-177	582.0	COG0246@1|root,COG0246@2|Bacteria,2GJ4F@201174|Actinobacteria,4DPWW@85009|Propionibacteriales	201174|Actinobacteria	G	Mannitol dehydrogenase Rossmann domain	mtlD	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
TLS3_k127_879947_0	1347086.CCBA010000009_gene1342	9.816e-255	828.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,1ZFH2@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	XK27_03135	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
TLS3_k127_879947_8	1120954.ATXE01000001_gene1742	1.705e-116	383.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	DUF2608,HAD_2,TetR_N
TLS3_k127_879947_10	1304865.JAGF01000001_gene2536	2.025e-99	346.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,2IETB@201174|Actinobacteria	201174|Actinobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
TLS3_k127_879947_1	1386089.N865_05100	5.387e-242	780.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4FF9M@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sulfate permease family	-	GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
TLS3_k127_879947_7	1122622.ATWJ01000011_gene2138	1.444e-122	402.0	COG2239@1|root,COG2239@2|Bacteria,2I9TV@201174|Actinobacteria	201174|Actinobacteria	P	Divalent cation transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE
TLS3_k127_879947_4	1386089.N865_07315	5.194e-202	649.0	COG1506@1|root,COG3247@1|root,COG1506@2|Bacteria,COG3247@2|Bacteria,2HFMK@201174|Actinobacteria,4FJMA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Secretory lipase	-	-	-	-	-	-	-	-	-	-	-	-	LIP
TLS3_k127_879947_6	1193181.BN10_200002	2.473e-134	430.0	COG2013@1|root,COG2013@2|Bacteria,2GSX6@201174|Actinobacteria,4FF6Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
TLS3_k127_879947_13	367299.JOEE01000002_gene2410	4.523e-18	91.0	29175@1|root,2ZNUA@2|Bacteria,2GTKT@201174|Actinobacteria,4FJK2@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_884157_6	1158050.KB895456_gene2110	7.62e-43	159.0	COG2318@1|root,COG2318@2|Bacteria,2IGJQ@201174|Actinobacteria	201174|Actinobacteria	H	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
TLS3_k127_884157_5	367299.JOEE01000007_gene69	1.618e-45	179.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4FG0U@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidase family M23	envC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
TLS3_k127_884157_8	196162.Noca_1250	2.969e-38	146.0	COG4770@1|root,COG4770@2|Bacteria,2GPU3@201174|Actinobacteria,4DVQ9@85009|Propionibacteriales	201174|Actinobacteria	I	Biotin-lipoyl like	-	-	2.1.3.1	ko:K17490	ko00640,map00640	-	R00353	RC00040	ko00000,ko00001,ko01000	-	-	-	Biotin_lipoyl
TLS3_k127_884157_10	196162.Noca_1249	3.069e-19	99.0	2EJZC@1|root,33DPX@2|Bacteria,2GYHI@201174|Actinobacteria,4DW75@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	2.1.3.1	ko:K17489	ko00640,map00640	-	R00353	RC00040	ko00000,ko00001,ko01000	-	-	-	-
TLS3_k127_884157_0	196162.Noca_1248	4.439e-290	896.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DU79@85009|Propionibacteriales	201174|Actinobacteria	I	Malonate decarboxylase gamma subunit (MdcE)	mmdA	-	2.1.3.1	ko:K17489	ko00640,map00640	-	R00353	RC00040	ko00000,ko00001,ko01000	-	-	-	Carboxyl_trans
TLS3_k127_884157_1	196162.Noca_1247	1.217e-282	874.0	COG5016@1|root,COG5016@2|Bacteria,2IASR@201174|Actinobacteria,4DWP1@85009|Propionibacteriales	201174|Actinobacteria	C	Conserved carboxylase domain	oadA	-	2.1.3.1	ko:K03416	ko00640,map00640	-	R00353,R00930	RC00040,RC00097	ko00000,ko00001,ko01000	-	-	-	HMGL-like,PYC_OADA
TLS3_k127_884157_4	1386089.N865_14865	7.268e-62	234.0	COG3147@1|root,COG3147@2|Bacteria,2HC8A@201174|Actinobacteria,4FGS7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
TLS3_k127_884157_3	1385521.N803_16220	1.847e-119	422.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4FE9P@85021|Intrasporangiaceae	201174|Actinobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
TLS3_k127_884157_7	1386089.N865_14875	1.289e-42	158.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4FHAS@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
TLS3_k127_884157_2	367299.JOEE01000003_gene2981	1.065e-154	496.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4FEE9@85021|Intrasporangiaceae	201174|Actinobacteria	S	2-phospho-L-lactate transferase	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
TLS3_k127_884157_9	710696.Intca_2521	4.976e-27	122.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4FG4N@85021|Intrasporangiaceae	201174|Actinobacteria	C	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
## 2965 queries scanned
## Total time (seconds): 107.63833975791931
## Rate: 27.55 q/s