## Tue Dec 16 15:02:02 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/WH3_bin.33.fa -m mmseqs --itype genome -o WH3_bin.33 --output_dir /data/result/bins/wyx/egg/WH3_bin.33 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
WH3_k127_10080559_3	279238.Saro_0561	6.408e-28	114.0	COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,2U5TA@28211|Alphaproteobacteria,2K48I@204457|Sphingomonadales	204457|Sphingomonadales	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
WH3_k127_10080559_0	1118054.CAGW01000046_gene1556	1.921e-84	284.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,4HA8J@91061|Bacilli,26T8H@186822|Paenibacillaceae	91061|Bacilli	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0006355,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051603,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
WH3_k127_10080559_2	525904.Tter_1278	1.811e-40	165.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
WH3_k127_10080559_1	1051632.TPY_0315	1.125e-63	223.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,3WCDQ@538999|Clostridiales incertae sedis	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WH3_k127_10144185_0	1237149.C900_01570	1.381e-246	780.0	COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,47K7C@768503|Cytophagia	976|Bacteroidetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
WH3_k127_10144185_3	868864.Dester_0074	2.384e-54	201.0	COG0758@1|root,COG0758@2|Bacteria,2G3ZI@200783|Aquificae	200783|Aquificae	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
WH3_k127_10144185_4	1408416.JNJT01000015_gene514	5.717e-41	157.0	COG0193@1|root,COG0193@2|Bacteria,3WT8R@544448|Tenericutes	544448|Tenericutes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
WH3_k127_10144185_2	632518.Calow_0598	3.641e-95	327.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,42F2X@68295|Thermoanaerobacterales	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
WH3_k127_10144185_6	1355368.JART01000001_gene799	1.028e-35	147.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,42P43@68525|delta/epsilon subdivisions,2YN55@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
WH3_k127_10144185_5	1156937.MFUM_970019	9.808e-37	147.0	COG1187@1|root,COG1187@2|Bacteria,46SWQ@74201|Verrucomicrobia,37GUY@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	RNA pseudouridylate synthase	rsuA	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WH3_k127_10144185_9	324602.Caur_3934	1.099e-19	94.0	COG1386@1|root,COG1386@2|Bacteria,2G6V6@200795|Chloroflexi,375NU@32061|Chloroflexia	32061|Chloroflexia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
WH3_k127_10144185_10	386415.NT01CX_2032	2.307e-17	91.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,36EKU@31979|Clostridiaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
WH3_k127_10144185_1	1437425.CSEC_0252	4.204e-101	344.0	COG0017@1|root,COG2606@1|root,COG0017@2|Bacteria,COG2606@2|Bacteria,2JGS0@204428|Chlamydiae	204428|Chlamydiae	J	Aminoacyl-tRNA editing domain	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_edit
WH3_k127_10144185_8	1121479.AUBS01000001_gene3528	6.032e-23	106.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
WH3_k127_10144185_7	269797.Mbar_A3236	6.017e-32	133.0	COG1018@1|root,arCOG02200@2157|Archaea,2XVD3@28890|Euryarchaeota,2N9JH@224756|Methanomicrobia	224756|Methanomicrobia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
WH3_k127_10232766_3	688269.Theth_1784	6.057e-25	105.0	COG0020@1|root,COG0020@2|Bacteria,2GC3V@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	iLJ478.TM1398	Prenyltransf
WH3_k127_10232766_2	255470.cbdbA313	9.533e-49	188.0	COG0750@1|root,COG0750@2|Bacteria,2G6HV@200795|Chloroflexi,34D8H@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
WH3_k127_10232766_5	1078085.HMPREF1210_01645	3.653e-15	84.0	COG1266@1|root,COG1266@2|Bacteria,1V26Z@1239|Firmicutes,4HG1I@91061|Bacilli,26ET5@186818|Planococcaceae	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WH3_k127_10232766_0	1449126.JQKL01000013_gene3436	6.783e-125	409.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
WH3_k127_10232766_4	370438.PTH_0818	1.104e-21	104.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,260H4@186807|Peptococcaceae	186801|Clostridia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
WH3_k127_10232766_1	1382356.JQMP01000004_gene482	2.396e-106	369.0	COG0768@1|root,COG0768@2|Bacteria,2G64Z@200795|Chloroflexi,27Y4X@189775|Thermomicrobia	189775|Thermomicrobia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
WH3_k127_10232766_6	1293054.HSACCH_00056	4.535e-14	74.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,3WAS0@53433|Halanaerobiales	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
WH3_k127_10255445_0	525904.Tter_0948	7.565e-204	647.0	COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria	2|Bacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
WH3_k127_10422318_2	926560.KE387023_gene3417	4.658e-26	115.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	KAP_NTPase,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
WH3_k127_10422318_1	749927.AMED_7789	1.484e-28	125.0	COG5542@1|root,COG5542@2|Bacteria,2I0QM@201174|Actinobacteria,4E29N@85010|Pseudonocardiales	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
WH3_k127_10426736_0	926569.ANT_30410	4.07e-63	230.0	COG0539@1|root,COG0539@2|Bacteria,2G656@200795|Chloroflexi	200795|Chloroflexi	J	PFAM RNA binding S1 domain protein	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
WH3_k127_10426736_2	360911.EAT1b_1882	5.106e-31	132.0	COG1482@1|root,COG1940@1|root,COG1482@2|Bacteria,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,4HBAU@91061|Bacilli,3WFZV@539002|Bacillales incertae sedis	91061|Bacilli	GK	Phosphomannose isomerase type I	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI,ROK
WH3_k127_10426736_3	1229780.BN381_90069	1.86e-25	115.0	COG1876@1|root,COG1876@2|Bacteria,2IQI8@201174|Actinobacteria	201174|Actinobacteria	M	peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	B_lectin,VanY
WH3_k127_10426736_6	318424.EU78_18010	3.465e-17	89.0	COG1388@1|root,COG1388@2|Bacteria,2IMTI@201174|Actinobacteria,23A5X@1762|Mycobacteriaceae	201174|Actinobacteria	M	Transglycosylase-like domain	rpfE	GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0009893,GO:0010468,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019222,GO:0040008,GO:0040009,GO:0040010,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0060255,GO:0065007	-	ko:K21687,ko:K21691	-	-	-	-	ko00000	-	GH23	-	Transglycosylas
WH3_k127_10426736_14	448385.sce6535	0.0002091	52.0	COG0739@1|root,COG0739@2|Bacteria,1QGHU@1224|Proteobacteria	1224|Proteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
WH3_k127_10426736_9	1122238.AULR01000002_gene411	2.576e-12	74.0	COG0741@1|root,COG0741@2|Bacteria,2GM11@201174|Actinobacteria,4FTPW@85023|Microbacteriaceae	201174|Actinobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
WH3_k127_10426736_13	1331060.RLDS_07105	6.34e-05	55.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,2K1Y8@204457|Sphingomonadales	204457|Sphingomonadales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
WH3_k127_10426736_11	671143.DAMO_0863	1.129e-06	53.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
WH3_k127_10426736_8	202952.BBLI01000179_gene4089	3.223e-13	70.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,1S5B2@1236|Gammaproteobacteria,3NN42@468|Moraxellaceae	1236|Gammaproteobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_10426736_4	936155.HFELIS_16070	2.871e-24	102.0	2AICC@1|root,318TJ@2|Bacteria,1Q0XM@1224|Proteobacteria,431XH@68525|delta/epsilon subdivisions,2YSDI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_10426736_12	1196031.ALEG01000052_gene562	8.409e-06	48.0	arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,4HFPA@91061|Bacilli,1ZH4V@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_10426736_10	445335.CBN_A0013	2.939e-11	65.0	2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,24JC8@186801|Clostridia,36RET@31979|Clostridiaceae	186801|Clostridia	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_10426736_1	748224.HMPREF9436_00081	2.085e-32	126.0	2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,24K1H@186801|Clostridia,3WJW5@541000|Ruminococcaceae	186801|Clostridia	S	non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_10426736_15	1232447.BAHW02000059_gene3412	0.0006524	42.0	2DVHW@1|root,33VZA@2|Bacteria,1VWIA@1239|Firmicutes,250WA@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_10687846_4	42256.RradSPS_1533	2.539e-35	141.0	COG0769@1|root,COG0769@2|Bacteria,2I2TV@201174|Actinobacteria,4CU6A@84995|Rubrobacteria	84995|Rubrobacteria	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
WH3_k127_10687846_1	86416.Clopa_3445	2.619e-61	219.0	COG3442@1|root,COG3442@2|Bacteria,1U7I9@1239|Firmicutes,24A80@186801|Clostridia,36DUC@31979|Clostridiaceae	186801|Clostridia	S	glutamine amidotransferase	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
WH3_k127_10687846_9	349521.HCH_05728	5.231e-13	78.0	COG1708@1|root,COG1708@2|Bacteria,1RCAH@1224|Proteobacteria,1S3KC@1236|Gammaproteobacteria,1XP9X@135619|Oceanospirillales	135619|Oceanospirillales	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
WH3_k127_10687846_5	1158606.I579_00473	1.119e-33	143.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,4H9SR@91061|Bacilli,4B0F4@81852|Enterococcaceae	91061|Bacilli	S	AI-2E family transporter	XK27_05220	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
WH3_k127_10687846_11	525904.Tter_0072	3.936e-08	61.0	COG2220@1|root,COG2220@2|Bacteria,2NR9T@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
WH3_k127_10687846_8	1427984.X271_00481	4.198e-13	72.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
WH3_k127_10687846_3	556268.OFAG_00272	5.136e-41	159.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2VHAM@28216|Betaproteobacteria,472XF@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
WH3_k127_10687846_10	1078085.HMPREF1210_00762	7.64e-10	66.0	COG3327@1|root,COG3327@2|Bacteria,1TRBU@1239|Firmicutes,4HCP9@91061|Bacilli,26GTY@186818|Planococcaceae	91061|Bacilli	K	PaaX-like protein C-terminal domain	paaX	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
WH3_k127_10687846_0	243274.THEMA_00270	9.398e-96	344.0	COG0542@1|root,COG0542@2|Bacteria,2GBZG@200918|Thermotogae	200918|Thermotogae	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
WH3_k127_10687846_6	1279017.AQYJ01000029_gene3430	6.312e-33	131.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,4683Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
WH3_k127_10687846_2	748727.CLJU_c15920	2.522e-55	203.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,36EFN@31979|Clostridiaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
WH3_k127_10687846_7	748449.Halha_1865	4.406e-28	118.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia	186801|Clostridia	L	PFAM ribonuclease H	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
WH3_k127_10687846_12	345341.KUTG_04140	2.848e-05	47.0	2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_107199_6	326427.Cagg_1669	3.332e-06	56.0	COG3428@1|root,COG3428@2|Bacteria,2G72V@200795|Chloroflexi,375TY@32061|Chloroflexia	32061|Chloroflexia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
WH3_k127_107199_0	1347369.CCAD010000057_gene4136	6.556e-128	417.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,4HBMW@91061|Bacilli,1ZC5A@1386|Bacillus	91061|Bacilli	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
WH3_k127_107199_3	596330.HMPREF0628_0198	1.909e-29	124.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,22H7D@1570339|Peptoniphilaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
WH3_k127_107199_4	29730.Gorai.011G272800.1	6.447e-19	96.0	COG0596@1|root,KOG1454@2759|Eukaryota,37MAP@33090|Viridiplantae,3GAYX@35493|Streptophyta	35493|Streptophyta	S	cell wall organization	-	GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0010224,GO:0050896	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
WH3_k127_107199_2	871963.Desdi_2527	1.299e-52	190.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,261I9@186807|Peptococcaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
WH3_k127_107199_1	1449126.JQKL01000012_gene3524	3.849e-65	230.0	COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,268H0@186813|unclassified Clostridiales	186801|Clostridia	K	Transcriptional regulator	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
WH3_k127_107199_5	1338011.BD94_0315	6.583e-17	94.0	COG0658@1|root,COG0658@2|Bacteria,4NEJH@976|Bacteroidetes,1HYJH@117743|Flavobacteriia,34RZ5@308865|Elizabethkingia	976|Bacteroidetes	S	Competence protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
WH3_k127_10832751_1	1121428.DESHY_50008___1	2.018e-25	114.0	COG1963@1|root,COG1963@2|Bacteria,1VAVC@1239|Firmicutes,24MV7@186801|Clostridia,26250@186807|Peptococcaceae	186801|Clostridia	S	PFAM Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
WH3_k127_10832751_0	1211035.CD30_02725	9.961e-279	879.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,3IWR6@400634|Lysinibacillus	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
WH3_k127_108590_2	1157943.KB892705_gene706	6.122e-84	305.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,235P5@1762|Mycobacteriaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
WH3_k127_108590_0	264732.Moth_0263	4.02e-114	380.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
WH3_k127_108590_3	479432.Sros_4978	5.517e-56	201.0	COG4243@1|root,COG4243@2|Bacteria,2GMVK@201174|Actinobacteria,4EJH9@85012|Streptosporangiales	201174|Actinobacteria	S	VKc	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
WH3_k127_108590_5	1244531.CIG1485E_1410	3.128e-31	137.0	COG0726@1|root,COG0726@2|Bacteria,1MZFC@1224|Proteobacteria,42M7D@68525|delta/epsilon subdivisions,2YN0H@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
WH3_k127_108590_6	237727.NAP1_01065	3.843e-10	68.0	2DF6E@1|root,32U4S@2|Bacteria,1N20C@1224|Proteobacteria,2UFPS@28211|Alphaproteobacteria,2K424@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_108590_7	1406840.Q763_01205	4.208e-10	64.0	COG2827@1|root,COG2827@2|Bacteria,4NUKY@976|Bacteroidetes,1II52@117743|Flavobacteriia,2NXVP@237|Flavobacterium	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
WH3_k127_108590_1	760568.Desku_1651	2.301e-88	310.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,260WY@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
WH3_k127_108590_4	525373.HMPREF0766_13998	9.571e-32	129.0	COG0149@1|root,COG0149@2|Bacteria,4NE2F@976|Bacteroidetes,1IPGF@117747|Sphingobacteriia	976|Bacteroidetes	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
WH3_k127_10865361_0	926692.AZYG01000047_gene2664	6.52e-149	484.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WANE@53433|Halanaerobiales	186801|Clostridia	L	Replicative DNA helicase	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
WH3_k127_10865361_1	1521187.JPIM01000002_gene3125	0.0001275	48.0	COG2812@1|root,COG2812@2|Bacteria,2G5PK@200795|Chloroflexi,37532@32061|Chloroflexia	32061|Chloroflexia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
WH3_k127_1091251_3	1379698.RBG1_1C00001G0223	1.468e-19	91.0	COG0284@1|root,COG0284@2|Bacteria,2NP92@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
WH3_k127_1091251_0	682795.AciX8_0552	1.37e-97	330.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	pyrD	-	1.3.1.14	ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,DHO_dh,NAD_binding_1
WH3_k127_1091251_1	1128421.JAGA01000003_gene3013	3.947e-92	314.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
WH3_k127_1091251_4	1297581.H919_08245	6.059e-15	85.0	COG1277@1|root,COG1277@2|Bacteria,1V1P1@1239|Firmicutes,4HCZ3@91061|Bacilli,21W53@150247|Anoxybacillus	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
WH3_k127_1091251_2	1219084.AP014508_gene1937	1.776e-71	251.0	COG1131@1|root,COG1131@2|Bacteria,2GC32@200918|Thermotogae	200918|Thermotogae	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WH3_k127_10936398_7	525260.HMPREF0276_0510	1.144e-10	71.0	COG1073@1|root,COG1073@2|Bacteria,2GJE5@201174|Actinobacteria,22RHM@1653|Corynebacteriaceae	201174|Actinobacteria	S	Secretory lipase	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	LIP
WH3_k127_10936398_1	662755.CRES_2173	6.365e-107	355.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,22KK5@1653|Corynebacteriaceae	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
WH3_k127_10936398_4	909663.KI867150_gene2841	1.589e-42	159.0	COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,431RV@68525|delta/epsilon subdivisions,2WWFG@28221|Deltaproteobacteria,2MS3I@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WH3_k127_10936398_3	1121085.AUCI01000012_gene2815	4.328e-57	213.0	COG0507@1|root,COG0507@2|Bacteria	2|Bacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	-	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,UvrD_C_2
WH3_k127_10936398_0	485913.Krac_10794	4.111e-198	634.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi	200795|Chloroflexi	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
WH3_k127_10936398_2	1461693.ATO10_09733	1.168e-82	294.0	COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,2U6K9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
WH3_k127_10936398_5	1416759.AYMR01000018_gene2208	1.743e-37	152.0	COG0596@1|root,COG0596@2|Bacteria,2I7C3@201174|Actinobacteria,4FM9Q@85023|Microbacteriaceae	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
WH3_k127_10961320_1	1128421.JAGA01000002_gene877	0.0	1058.0	COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WH3_k127_10961320_0	479434.Sthe_1030	0.0	1214.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi,27Y0B@189775|Thermomicrobia	189775|Thermomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
WH3_k127_10961320_2	525367.HMPREF0556_10393	2.486e-61	213.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,4HFMZ@91061|Bacilli,26KJM@186820|Listeriaceae	91061|Bacilli	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WH3_k127_10961320_4	391009.Tmel_0949	1.483e-42	160.0	COG0049@1|root,COG0049@2|Bacteria,2GCUI@200918|Thermotogae	200918|Thermotogae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
WH3_k127_10961320_3	555793.WSK_0477	1.207e-47	175.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2TR6D@28211|Alphaproteobacteria,2K0QP@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WH3_k127_10961320_5	1122970.AUHC01000009_gene238	9.687e-41	151.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,2K1ND@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
WH3_k127_11346612_0	221027.JO40_11830	3.463e-77	287.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
WH3_k127_11346612_1	1499968.TCA2_0278	1.423e-56	205.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,4HAWU@91061|Bacilli,26S9I@186822|Paenibacillaceae	91061|Bacilli	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
WH3_k127_11346612_3	1120973.AQXL01000120_gene845	2.103e-14	81.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	apfA	-	2.7.7.72,3.6.1.55,3.6.1.61	ko:K00974,ko:K03574,ko:K18445	ko00230,ko03013,map00230,map03013	-	R00184,R09382,R09383,R09384,R09386	RC00002,RC00078	ko00000,ko00001,ko01000,ko03016,ko03400	-	-	-	NUDIX
WH3_k127_11346612_2	485913.Krac_8246	6.644e-28	119.0	COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi	200795|Chloroflexi	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
WH3_k127_11412251_2	927704.SELR_00020	3.32e-48	185.0	COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,4H3IY@909932|Negativicutes	909932|Negativicutes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
WH3_k127_11412251_1	411463.EUBVEN_01632	1.042e-50	194.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,25V7R@186806|Eubacteriaceae	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
WH3_k127_11412251_6	103733.JNYO01000057_gene985	0.0008684	51.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M23
WH3_k127_11412251_4	313589.JNB_19983	1.995e-19	101.0	COG3583@1|root,COG3583@2|Bacteria,2I5X7@201174|Actinobacteria,4FJ8G@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36
WH3_k127_11412251_3	1229780.BN381_220032	2.144e-32	147.0	COG1876@1|root,COG1876@2|Bacteria,2IQI8@201174|Actinobacteria	201174|Actinobacteria	M	peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	B_lectin,VanY
WH3_k127_11412251_0	479433.Caci_4080	5.416e-123	417.0	COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria	201174|Actinobacteria	U	Type IV secretory pathway, VirB4	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
WH3_k127_11412251_5	485913.Krac_5206	1.154e-08	66.0	COG3451@1|root,COG3451@2|Bacteria	2|Bacteria	U	multi-organism process	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
WH3_k127_11413982_3	926550.CLDAP_37220	3.229e-06	59.0	COG2374@1|root,COG3266@1|root,COG2374@2|Bacteria,COG3266@2|Bacteria,2G8M8@200795|Chloroflexi	200795|Chloroflexi	G	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	LTD
WH3_k127_11413982_1	698758.AXY_03600	3.219e-22	102.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,4HIIF@91061|Bacilli	91061|Bacilli	M	ATPase or kinase	ydiB	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
WH3_k127_11413982_2	626369.HMPREF0446_01597	4.294e-10	66.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4HHD7@91061|Bacilli,27F7H@186828|Carnobacteriaceae	91061|Bacilli	O	Glycoprotease family	yeaZ	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WH3_k127_11413982_0	635013.TherJR_1279	2.982e-114	383.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,25ZZN@186807|Peptococcaceae	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
WH3_k127_11577591_0	1122919.KB905578_gene3273	1.266e-284	889.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,4HAB8@91061|Bacilli,26RH1@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WH3_k127_11577591_1	208439.AJAP_30565	1.419e-06	58.0	COG1051@1|root,COG1051@2|Bacteria,2I8YY@201174|Actinobacteria,4E2M5@85010|Pseudonocardiales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
WH3_k127_11668773_3	518637.EUBIFOR_00368	1.039e-09	59.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,3VNR1@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
WH3_k127_11668773_6	394503.Ccel_3377	0.0008371	48.0	COG0346@1|root,COG0346@2|Bacteria,1VC53@1239|Firmicutes,24ICT@186801|Clostridia,36IP2@31979|Clostridiaceae	186801|Clostridia	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
WH3_k127_11668773_2	631454.N177_4048	6.353e-10	68.0	COG1011@1|root,COG1011@2|Bacteria,1RHAB@1224|Proteobacteria,2U7PV@28211|Alphaproteobacteria,1JPC3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
WH3_k127_11668773_1	403833.Pmob_1910	5.834e-17	83.0	COG0776@1|root,COG0776@2|Bacteria,2GDFH@200918|Thermotogae	200918|Thermotogae	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
WH3_k127_11668773_0	797210.Halxa_1471	4.087e-109	366.0	COG2239@1|root,arCOG00625@2157|Archaea,2XSUY@28890|Euryarchaeota,23UI0@183963|Halobacteria	183963|Halobacteria	P	transporter, MgtE	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
WH3_k127_11668773_5	1121267.JHZL01000028_gene1872	1.104e-06	50.0	2A4CB@1|root,30SXZ@2|Bacteria,1PCGS@1224|Proteobacteria,42W82@68525|delta/epsilon subdivisions,2YQMV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_11683625_4	665952.HMPREF1015_00158	3.195e-52	196.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,1ZDBF@1386|Bacillus	91061|Bacilli	L	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WH3_k127_11683625_0	857293.CAAU_1984	1.546e-168	549.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,36E85@31979|Clostridiaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
WH3_k127_11683625_5	351627.Csac_2378	2.703e-45	171.0	COG0586@1|root,COG0586@2|Bacteria,1TS2R@1239|Firmicutes,24HX6@186801|Clostridia,42GCF@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WH3_k127_11683625_1	457570.Nther_1453	4.222e-77	273.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia	186801|Clostridia	S	peptidase, M16	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
WH3_k127_11683625_3	768679.TTX_0564	2.278e-56	202.0	COG0105@1|root,arCOG04313@2157|Archaea,2XQEV@28889|Crenarchaeota	28889|Crenarchaeota	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
WH3_k127_11683625_13	1423321.AS29_20610	2.333e-09	64.0	COG0494@1|root,COG0494@2|Bacteria,1V6ET@1239|Firmicutes,4HIP6@91061|Bacilli,1ZG7Z@1386|Bacillus	91061|Bacilli	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WH3_k127_11683625_6	926549.KI421517_gene3792	1.333e-36	145.0	COG0122@1|root,COG0122@2|Bacteria,4NMMI@976|Bacteroidetes,47PBD@768503|Cytophagia	976|Bacteroidetes	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
WH3_k127_11683625_2	863239.AFIZ01000007_gene96	1.934e-66	235.0	COG0406@1|root,COG0406@2|Bacteria,2GN7B@201174|Actinobacteria,22MPI@1653|Corynebacteriaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WH3_k127_11683625_8	40483.S8DK20	1.264e-24	109.0	COG3236@1|root,2S0ST@2759|Eukaryota,3A3WV@33154|Opisthokonta,3Q3AA@4751|Fungi,3VC75@5204|Basidiomycota,22F9C@155619|Agaricomycetes,3H5Q6@355688|Agaricomycetes incertae sedis	33154|Opisthokonta	S	Domain of unknown function (DUF1768)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1768
WH3_k127_11683625_9	767817.Desgi_2843	1.802e-22	105.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,261T1@186807|Peptococcaceae	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
WH3_k127_11683625_7	1476973.JMMB01000007_gene3240	6.311e-30	132.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,25UIJ@186804|Peptostreptococcaceae	186801|Clostridia	M	SurA N-terminal domain	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
WH3_k127_11683625_15	179408.Osc7112_6890	0.0001534	52.0	2E6ZW@1|root,331IY@2|Bacteria,1GEE7@1117|Cyanobacteria,1HG1Q@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_11683625_14	1122925.KB895387_gene2807	4.694e-05	49.0	2DREZ@1|root,33BFB@2|Bacteria,1UPXP@1239|Firmicutes,4IVCS@91061|Bacilli,2743X@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_11683625_12	1121937.AUHJ01000008_gene1961	8.814e-11	69.0	2E1PZ@1|root,32X0D@2|Bacteria,1N001@1224|Proteobacteria,1S9M7@1236|Gammaproteobacteria,46BQ8@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_11683625_10	411467.BACCAP_04820	3.398e-14	79.0	COG0454@1|root,COG0456@2|Bacteria,1U05V@1239|Firmicutes,2559C@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WH3_k127_11683625_11	1501230.ET33_24860	7.052e-11	70.0	COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes,4HGAV@91061|Bacilli,26U9A@186822|Paenibacillaceae	91061|Bacilli	S	HAD superfamily	yqeG	-	-	ko:K07015	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase
WH3_k127_1194314_5	87626.PTD2_21532	1.185e-23	104.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,2Q1DF@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
WH3_k127_1194314_6	298654.FraEuI1c_0202	6.176e-22	103.0	COG3409@1|root,COG3409@2|Bacteria,2HKP4@201174|Actinobacteria,4EVKS@85013|Frankiales	201174|Actinobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglycosylas
WH3_k127_1194314_0	748449.Halha_1653	8.33e-96	335.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WAFK@53433|Halanaerobiales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WH3_k127_1194314_1	1206737.BAGF01000056_gene3484	7.529e-66	235.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4FTWY@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
WH3_k127_1194314_2	1329516.JPST01000063_gene1788	1.041e-65	229.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4HBDV@91061|Bacilli,27AYI@186824|Thermoactinomycetaceae	91061|Bacilli	J	Elongation factor TS	tsf	GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
WH3_k127_1194314_4	595460.RRSWK_04493	1.817e-39	153.0	COG0233@1|root,COG0233@2|Bacteria,2IYYY@203682|Planctomycetes	203682|Planctomycetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
WH3_k127_1194314_3	525904.Tter_1516	1.811e-56	203.0	COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
WH3_k127_12011757_5	572547.Amico_1161	1.398e-25	106.0	COG0481@1|root,COG0481@2|Bacteria,3TA5E@508458|Synergistetes	508458|Synergistetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
WH3_k127_12011757_1	1449126.JQKL01000018_gene3286	5.56e-72	263.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,26BKG@186813|unclassified Clostridiales	186801|Clostridia	S	MviN-like protein	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
WH3_k127_12011757_0	525904.Tter_1052	1.705e-208	664.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
WH3_k127_12011757_4	313598.MED152_09965	6.312e-43	174.0	COG0037@1|root,COG0037@2|Bacteria,4NEJS@976|Bacteroidetes,1HYBN@117743|Flavobacteriia,3VVG7@52959|Polaribacter	976|Bacteroidetes	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
WH3_k127_12011757_3	402881.Plav_0870	1.833e-50	190.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
WH3_k127_12011757_2	386456.JQKN01000022_gene62	5.157e-64	227.0	COG5621@1|root,arCOG12321@2157|Archaea,2Y2ME@28890|Euryarchaeota	28890|Euryarchaeota	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
WH3_k127_12531770_1	999423.HMPREF9161_00344	1.092e-47	183.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H360@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding Protein	pbpD	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
WH3_k127_12531770_0	484019.THA_408	2.914e-106	357.0	COG0162@1|root,COG0162@2|Bacteria,2GCKH@200918|Thermotogae	200918|Thermotogae	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iLJ478.TM0478	S4,tRNA-synt_1b
WH3_k127_12577071_7	1123230.ARQJ01000008_gene1075	7.218e-60	228.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli,4GXXM@90964|Staphylococcaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	ydiF	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
WH3_k127_12577071_4	317936.Nos7107_5439	2.233e-77	271.0	COG1304@1|root,COG1304@2|Bacteria,1G2KC@1117|Cyanobacteria,1HICD@1161|Nostocales	1117|Cyanobacteria	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
WH3_k127_12577071_34	1284352.AOIG01000018_gene4328	6.848e-16	82.0	COG4818@1|root,COG4818@2|Bacteria,1VG59@1239|Firmicutes,4HP4V@91061|Bacilli,26ZHT@186822|Paenibacillaceae	91061|Bacilli	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_12577071_11	643648.Slip_2237	3.365e-54	197.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,42JTZ@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
WH3_k127_12577071_22	1089553.Tph_c25840	2.485e-37	149.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,42ERX@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
WH3_k127_12577071_35	335541.Swol_2331	6.227e-14	74.0	COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,24MN8@186801|Clostridia,42K40@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
WH3_k127_12577071_1	1304880.JAGB01000003_gene1207	9.163e-96	320.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WH3_k127_12577071_25	867845.KI911784_gene934	1.169e-33	131.0	COG0185@1|root,COG0185@2|Bacteria,2G6US@200795|Chloroflexi,377CN@32061|Chloroflexia	32061|Chloroflexia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
WH3_k127_12577071_37	1125863.JAFN01000001_gene3300	5.143e-12	71.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
WH3_k127_12577071_6	1122216.AUHW01000005_gene468	1.543e-66	232.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,4H3BP@909932|Negativicutes	909932|Negativicutes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
WH3_k127_12577071_14	864702.OsccyDRAFT_3433	2.13e-51	185.0	COG0197@1|root,COG0197@2|Bacteria,1G55B@1117|Cyanobacteria,1HARZ@1150|Oscillatoriales	1117|Cyanobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
WH3_k127_12577071_43	27289.XP_003667618.1	0.0001414	46.0	COG0255@1|root,KOG3436@2759|Eukaryota,3A1TW@33154|Opisthokonta,3P3ZG@4751|Fungi,3QV25@4890|Ascomycota,3RUIS@4891|Saccharomycetes,3S19P@4893|Saccharomycetaceae	4751|Fungi	J	to Saccharomyces cerevisiae RPL35A (YDL191W) and RPL35B (YDL136W)	rpl35	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02918	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
WH3_k127_12577071_31	596330.HMPREF0628_0301	2.603e-22	98.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,22HGZ@1570339|Peptoniphilaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
WH3_k127_12577071_15	1410628.JNKS01000017_gene151	2.599e-50	181.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,27MQ8@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
WH3_k127_12577071_28	1122921.KB898209_gene2702	4.317e-26	111.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,26XQC@186822|Paenibacillaceae	91061|Bacilli	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
WH3_k127_12577071_9	1267533.KB906735_gene5118	2.69e-58	207.0	COG0094@1|root,COG0094@2|Bacteria,3Y3PS@57723|Acidobacteria,2JHV4@204432|Acidobacteriia	204432|Acidobacteriia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
WH3_k127_12577071_24	643867.Ftrac_3045	8.518e-34	132.0	COG0199@1|root,COG0199@2|Bacteria,4NQ6N@976|Bacteroidetes,47QB0@768503|Cytophagia	976|Bacteroidetes	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
WH3_k127_12577071_23	926569.ANT_10180	6.638e-36	140.0	COG0096@1|root,COG0096@2|Bacteria,2G6XS@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
WH3_k127_12577071_13	1401067.HMPREF0872_08580	3.909e-52	189.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,4H3Z2@909932|Negativicutes	909932|Negativicutes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
WH3_k127_12577071_30	838561.P344_01760	2.352e-22	100.0	COG0256@1|root,COG0256@2|Bacteria,3WTJJ@544448|Tenericutes	544448|Tenericutes	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
WH3_k127_12577071_19	1121422.AUMW01000023_gene2770	1.919e-42	160.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,261HV@186807|Peptococcaceae	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
WH3_k127_12577071_27	1347086.CCBA010000014_gene685	2.174e-27	117.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli,1ZFMY@1386|Bacillus	91061|Bacilli	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
WH3_k127_12577071_2	525903.Taci_1164	9.476e-95	326.0	COG0201@1|root,COG0201@2|Bacteria,3TA0Z@508458|Synergistetes	508458|Synergistetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
WH3_k127_12577071_26	1336234.JAGN01000021_gene811	1.915e-31	124.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,27GMT@186828|Carnobacteriaceae	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
WH3_k127_12577071_36	525282.HMPREF0391_11282	2.438e-12	66.0	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia,22I1W@1570339|Peptoniphilaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
WH3_k127_12577071_20	429009.Adeg_1499	1.449e-41	156.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,42G97@68295|Thermoanaerobacterales	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
WH3_k127_12577071_18	1382306.JNIM01000001_gene3523	9.596e-43	160.0	COG0100@1|root,COG0100@2|Bacteria,2G6HG@200795|Chloroflexi	200795|Chloroflexi	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
WH3_k127_12577071_10	1408823.AXUS01000017_gene1143	7.493e-57	205.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,25SHG@186804|Peptostreptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
WH3_k127_12577071_5	485913.Krac_12501	1.883e-72	256.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
WH3_k127_12577071_32	1265756.AWZW01000008_gene1050	9.853e-22	101.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,4BQGB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
WH3_k127_12577071_16	1219626.HMPREF1639_00395	2.916e-50	182.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,25R9X@186804|Peptostreptococcaceae	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
WH3_k127_12577071_21	1033837.WANG_0027	1.257e-37	145.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,4HH3B@91061|Bacilli,3F656@33958|Lactobacillaceae	91061|Bacilli	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
WH3_k127_12577071_12	573064.Mefer_0597	1.95e-52	198.0	COG1226@1|root,arCOG01958@2157|Archaea,2XT46@28890|Euryarchaeota,23QCY@183939|Methanococci	183939|Methanococci	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
WH3_k127_12577071_8	243164.DET1375	1.164e-58	214.0	COG0564@1|root,COG0564@2|Bacteria,2G68N@200795|Chloroflexi,34D96@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WH3_k127_12577071_40	316275.VSAL_I2246	8.451e-08	63.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1XU24@135623|Vibrionales	135623|Vibrionales	L	dna polymerase iii	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
WH3_k127_12577071_39	331678.Cphamn1_0588	1.429e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,1FDVB@1090|Chlorobi	1090|Chlorobi	S	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
WH3_k127_12577071_17	272624.lpg0067	7.85e-48	179.0	COG3545@1|root,COG3545@2|Bacteria,1RKTI@1224|Proteobacteria	1224|Proteobacteria	S	esterase of the alpha beta hydrolase fold	ydeN	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
WH3_k127_12577071_38	1033837.WANG_0184	8.711e-09	59.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,4HRGW@91061|Bacilli,3F87Y@33958|Lactobacillaceae	91061|Bacilli	KT	PspC domain	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
WH3_k127_12577071_0	639282.DEFDS_1188	9.253e-132	433.0	COG0151@1|root,COG0151@2|Bacteria,2GEYF@200930|Deferribacteres	200930|Deferribacteres	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
WH3_k127_12577071_29	313598.MED152_12354	2.53e-24	108.0	COG3603@1|root,COG3603@2|Bacteria	2|Bacteria	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_12577071_3	868864.Dester_0385	2.225e-85	300.0	COG2804@1|root,COG2804@2|Bacteria,2G4H7@200783|Aquificae	200783|Aquificae	NU	PFAM Type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
WH3_k127_12639736_2	416591.Tlet_1009	2.056e-17	87.0	COG0745@1|root,COG0745@2|Bacteria,2GDAM@200918|Thermotogae	200918|Thermotogae	T	PFAM response regulator receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
WH3_k127_12639736_0	648996.Theam_0215	1.549e-44	173.0	COG0223@1|root,COG0223@2|Bacteria,2G3PD@200783|Aquificae	200783|Aquificae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
WH3_k127_12639736_1	491916.RHECIAT_CH0000454	3.285e-28	120.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,4B7Z0@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.31,3.5.1.88	ko:K01450,ko:K01462	ko00270,ko00630,map00270,map00630	-	R00653	RC00165,RC00323	ko00000,ko00001,ko01000	-	-	-	Pep_deformylase
WH3_k127_12664351_0	1432056.X781_13330	6.214e-198	648.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1Y7ZN@135625|Pasteurellales	135625|Pasteurellales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WH3_k127_12664351_1	1172185.KB911515_gene2239	3.197e-13	72.0	COG1670@1|root,COG1670@2|Bacteria,2IGQ7@201174|Actinobacteria,4G103@85025|Nocardiaceae	201174|Actinobacteria	J	Siderophore biosynthesis protein domain	-	-	2.3.1.82	ko:K00663	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Acetyltransf_8
WH3_k127_12856693_10	1215343.B488_09190	7.394e-10	63.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,4B8C4@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speF	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
WH3_k127_12856693_7	639282.DEFDS_0496	6.909e-16	90.0	COG0612@1|root,COG0612@2|Bacteria,2GF7I@200930|Deferribacteres	200930|Deferribacteres	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
WH3_k127_12856693_3	58123.JOFJ01000005_gene1355	2.898e-91	320.0	COG0488@1|root,COG0488@2|Bacteria,2GK9S@201174|Actinobacteria,4EM6N@85012|Streptosporangiales	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yjjK	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
WH3_k127_12856693_6	354242.CJJ81176_1152	2.858e-23	113.0	COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1QU2Q@1224|Proteobacteria,43BK5@68525|delta/epsilon subdivisions,2YN4Y@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
WH3_k127_12856693_11	1089545.KB913037_gene1648	7.615e-07	54.0	2BZJJ@1|root,334TR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_12856693_4	656024.FsymDg_4426	1.448e-25	109.0	COG1162@1|root,COG1162@2|Bacteria,2GU32@201174|Actinobacteria,4EWKA@85013|Frankiales	201174|Actinobacteria	S	RNHCP domain	-	-	-	-	-	-	-	-	-	-	-	-	RNHCP
WH3_k127_12856693_0	555088.DealDRAFT_1815	2.095e-145	475.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,42K3N@68298|Syntrophomonadaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WH3_k127_12856693_1	588581.Cpap_2946	5.301e-135	443.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3WHYK@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
WH3_k127_12856693_8	545697.HMPREF0216_00704	6.261e-12	73.0	COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,24CEQ@186801|Clostridia,36JJM@31979|Clostridiaceae	186801|Clostridia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
WH3_k127_12856693_2	886293.Sinac_4765	3.053e-113	406.0	COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,2J50K@203682|Planctomycetes	203682|Planctomycetes	U	Pkd domain containing protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	-
WH3_k127_12856693_5	118161.KB235922_gene3791	1.136e-24	122.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9,DUF1565
WH3_k127_12856693_9	593750.Metfor_0594	6.28e-11	68.0	COG2940@1|root,arCOG05186@2157|Archaea	2157|Archaea	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
WH3_k127_12875131_1	304371.MCP_1988	7.818e-75	266.0	COG2379@1|root,arCOG04170@2157|Archaea,2XSTZ@28890|Euryarchaeota,2NAMM@224756|Methanomicrobia	224756|Methanomicrobia	G	Domain of unknown function (DUF4147)	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
WH3_k127_12875131_0	1163730.FFONT_0133	1.376e-84	294.0	COG0148@1|root,arCOG01169@2157|Archaea,2XPZ6@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
WH3_k127_12875131_2	631454.N177_0044	4.269e-39	151.0	COG1052@1|root,COG1052@2|Bacteria,1MVSS@1224|Proteobacteria,2VFXB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
WH3_k127_13025587_4	937777.Deipe_2321	1.293e-21	104.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,CHAT,DUF676,Hydrolase_4,LCAT,LIP,Peptidase_C14
WH3_k127_13025587_5	331113.SNE_A03480	6.318e-19	90.0	COG0261@1|root,COG0261@2|Bacteria,2JGD4@204428|Chlamydiae	204428|Chlamydiae	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
WH3_k127_13025587_0	1121335.Clst_0008	2.71e-82	280.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WGTZ@541000|Ruminococcaceae	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
WH3_k127_13025587_1	246194.CHY_0010	1.017e-62	226.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,42FPF@68295|Thermoanaerobacterales	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
WH3_k127_13025587_3	1321784.HMPREF1987_00435	1.072e-26	119.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
WH3_k127_13025587_2	926550.CLDAP_29190	1.426e-41	169.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
WH3_k127_13025587_6	908340.HMPREF9406_1236	3.054e-16	84.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,36DM2@31979|Clostridiaceae	186801|Clostridia	O	PDZ DHR GLGF domain protein	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
WH3_k127_13261611_2	521045.Kole_1971	6.839e-72	254.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2GDZE@200918|Thermotogae	200918|Thermotogae	L	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,TaqI_C
WH3_k127_13261611_0	521045.Kole_1972	9.704e-252	814.0	COG0553@1|root,COG3886@1|root,COG0553@2|Bacteria,COG3886@2|Bacteria,2GDGR@200918|Thermotogae	200918|Thermotogae	L	helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883,Helicase_C,PLDc_2,SNF2_N
WH3_k127_13261611_1	1121354.AQUV01000002_gene1128	1.716e-197	635.0	COG1002@1|root,COG1002@2|Bacteria,2IA5I@201174|Actinobacteria,22KP6@1653|Corynebacteriaceae	201174|Actinobacteria	V	Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
WH3_k127_13261611_3	697281.Mahau_2830	2.157e-50	196.0	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1TPHP@1239|Firmicutes,24E7K@186801|Clostridia,42FIJ@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM DNA methylase N-4 N-6 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
WH3_k127_13261611_4	1432056.X781_20660	2.967e-27	124.0	COG5362@1|root,COG5362@2|Bacteria,1N1KT@1224|Proteobacteria,1RRC7@1236|Gammaproteobacteria,1Y875@135625|Pasteurellales	135625|Pasteurellales	S	TIGRFAM Phage	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_13389156_1	331678.Cphamn1_2060	4.582e-21	96.0	COG0254@1|root,COG0254@2|Bacteria,1FEBT@1090|Chlorobi	1090|Chlorobi	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
WH3_k127_13389156_0	292563.Cyast_1998	2.099e-61	218.0	COG0216@1|root,COG0216@2|Bacteria,1FZY4@1117|Cyanobacteria	1117|Cyanobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
WH3_k127_13407557_3	932678.THERU_05500	8.32e-16	80.0	COG1104@1|root,COG1104@2|Bacteria,2G4UF@200783|Aquificae	200783|Aquificae	E	PFAM aminotransferase class V	nifS2	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
WH3_k127_13407557_2	189425.PGRAT_25940	1.691e-17	90.0	COG1434@1|root,COG1434@2|Bacteria,1VB45@1239|Firmicutes,4HMVM@91061|Bacilli,26U1E@186822|Paenibacillaceae	91061|Bacilli	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
WH3_k127_13407557_1	1203602.HMPREF1527_00153	5.286e-90	307.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4CU8F@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
WH3_k127_13407557_0	1307761.L21SP2_1037	6.872e-185	596.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WH3_k127_13407557_4	1435051.BMOU_1807	2.113e-08	64.0	2EGCD@1|root,33A46@2|Bacteria,2I2HS@201174|Actinobacteria,4D1EH@85004|Bifidobacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
WH3_k127_13451571_2	1121422.AUMW01000030_gene59	4.693e-10	61.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,260JQ@186807|Peptococcaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WH3_k127_13451571_0	710687.KI912270_gene3592	1.596e-115	394.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2HUK9@201174|Actinobacteria,23BT3@1762|Mycobacteriaceae	201174|Actinobacteria	LV	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
WH3_k127_13451571_1	1047013.AQSP01000140_gene2469	1.487e-48	175.0	COG2986@1|root,COG2986@2|Bacteria,2NQHF@2323|unclassified Bacteria	2|Bacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
WH3_k127_13809525_2	1042156.CXIVA_02700	5.144e-24	104.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,36KFP@31979|Clostridiaceae	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
WH3_k127_13809525_0	525909.Afer_1768	9.105e-117	391.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4CMU2@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WH3_k127_13809525_1	525904.Tter_1611	8.284e-49	183.0	COG2348@1|root,COG2348@2|Bacteria	2|Bacteria	V	transferase activity, transferring amino-acyl groups	murM	-	2.3.2.10,2.3.2.16,2.3.2.17,2.3.2.18	ko:K05363,ko:K11693,ko:K11694,ko:K11695,ko:K12554,ko:K18354	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	R08776,R08777,R08778,R08779,R08780	RC00055,RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	FemAB
WH3_k127_1444092_0	246194.CHY_2348	9.166e-204	648.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
WH3_k127_1444092_1	1408823.AXUS01000015_gene1457	2.135e-132	436.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,25QSV@186804|Peptostreptococcaceae	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
WH3_k127_1444092_3	485913.Krac_11275	8.645e-65	230.0	COG4956@1|root,COG4956@2|Bacteria,2G5YK@200795|Chloroflexi	200795|Chloroflexi	S	SMART Nucleotide binding protein, PINc	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
WH3_k127_1444092_2	1128421.JAGA01000002_gene1247	3.255e-69	257.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
WH3_k127_1726496_0	243232.MJ_1174	7.179e-88	295.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,23QIJ@183939|Methanococci	183939|Methanococci	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
WH3_k127_1726496_2	546414.Deide_07070	1.288e-29	123.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	GO:0003674,GO:0003824,GO:0016787	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Acetyltransf_3,NUDIX
WH3_k127_1726496_1	696369.KI912183_gene1994	2.853e-79	276.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,260NF@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
WH3_k127_1846925_3	1545702.LACWKB8_0463	1.093e-14	80.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,4HKIA@91061|Bacilli,3F6YZ@33958|Lactobacillaceae	91061|Bacilli	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
WH3_k127_1846925_6	401473.BDP_0530	7.473e-08	62.0	2EGCD@1|root,33A46@2|Bacteria,2I2HS@201174|Actinobacteria,4D1EH@85004|Bifidobacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
WH3_k127_1846925_2	714313.LSA_04710	8.978e-28	119.0	COG2813@1|root,COG2813@2|Bacteria,1V1BG@1239|Firmicutes,4HHCA@91061|Bacilli,3F4NU@33958|Lactobacillaceae	91061|Bacilli	J	Methyltransferase	rsmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
WH3_k127_1846925_0	1128421.JAGA01000002_gene1661	3.439e-88	306.0	COG0536@1|root,COG0536@2|Bacteria,2NNS6@2323|unclassified Bacteria	2|Bacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043021,GO:0043022,GO:0043167,GO:0043168,GO:0043934,GO:0044424,GO:0044464,GO:0044877,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
WH3_k127_1846925_5	1329250.WOSG25_090920	1.228e-13	83.0	COG1388@1|root,COG3942@1|root,COG1388@2|Bacteria,COG3942@2|Bacteria,1VCXB@1239|Firmicutes,4HI90@91061|Bacilli,4AY79@81850|Leuconostocaceae	91061|Bacilli	M	CHAP domain	sle1	-	3.5.1.28	ko:K21471,ko:K22409	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	CBM50	-	CHAP,LysM
WH3_k127_1846925_1	1292035.H476_1982	1.719e-48	187.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,25QDY@186804|Peptostreptococcaceae	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
WH3_k127_1846925_4	159087.Daro_3892	1.837e-14	80.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,2KWP7@206389|Rhodocyclales	206389|Rhodocyclales	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
WH3_k127_1846925_7	926692.AZYG01000064_gene1036	1.017e-07	57.0	COG0849@1|root,COG0849@2|Bacteria,1UD79@1239|Firmicutes,25HUK@186801|Clostridia,3WBK1@53433|Halanaerobiales	186801|Clostridia	D	Cell division protein FtsA	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
WH3_k127_1963984_8	313612.L8106_02337	3.846e-25	111.0	COG1708@1|root,COG1708@2|Bacteria,1G75J@1117|Cyanobacteria,1HC44@1150|Oscillatoriales	1117|Cyanobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_1963984_4	68199.JNZO01000006_gene2765	3.875e-30	126.0	COG0454@1|root,COG0456@2|Bacteria,2IEJU@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WH3_k127_1963984_12	204669.Acid345_4026	2.64e-08	65.0	COG0628@1|root,COG0628@2|Bacteria,3Y4A3@57723|Acidobacteria,2JJ4Y@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
WH3_k127_1963984_1	1147.D082_25660	1.796e-56	223.0	COG2931@1|root,COG3204@1|root,COG3210@1|root,COG5184@1|root,COG2931@2|Bacteria,COG3204@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,1G5KY@1117|Cyanobacteria,1H6DE@1142|Synechocystis	1117|Cyanobacteria	QU	Cadherin repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,HemolysinCabind,VCBS
WH3_k127_1963984_2	1004149.AFOE01000035_gene994	2.029e-49	201.0	COG1361@1|root,COG2373@1|root,COG2911@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,4NMB8@976|Bacteroidetes,1HZAG@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
WH3_k127_1963984_6	285514.JNWO01000001_gene4642	1.611e-28	121.0	COG3265@1|root,COG3265@2|Bacteria,2IGAU@201174|Actinobacteria	201174|Actinobacteria	G	gluconokinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_1963984_13	935837.JAEK01000019_gene757	1.245e-07	60.0	COG1936@1|root,COG1936@2|Bacteria,1UK2N@1239|Firmicutes,4ITGG@91061|Bacilli,1ZSBM@1386|Bacillus	91061|Bacilli	F	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,AAA_33
WH3_k127_1963984_3	1122138.AQUZ01000078_gene6113	1.224e-43	166.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria,4DW8U@85009|Propionibacteriales	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
WH3_k127_1963984_0	765952.PUV_20360	4.251e-63	223.0	COG0500@1|root,COG0500@2|Bacteria,2JH04@204428|Chlamydiae	204428|Chlamydiae	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_1963984_10	1385935.N836_29495	8.568e-14	79.0	2DEH3@1|root,2ZMZ5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_1963984_5	744872.Spica_2863	9.136e-30	121.0	COG4430@1|root,COG4430@2|Bacteria,2JBBZ@203691|Spirochaetes	203691|Spirochaetes	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
WH3_k127_1963984_9	1120971.AUCA01000087_gene1247	2.057e-14	80.0	2EC7T@1|root,3366B@2|Bacteria,1W244@1239|Firmicutes,4I0K6@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_2071743_0	926550.CLDAP_06600	2.25e-194	620.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
WH3_k127_2071743_1	1379698.RBG1_1C00001G1620	7.304e-58	214.0	COG2222@1|root,COG2222@2|Bacteria,2NQVV@2323|unclassified Bacteria	2|Bacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	pgi	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
WH3_k127_2071743_5	1056495.Calag_1543	7.64e-10	66.0	COG0500@1|root,arCOG01631@2157|Archaea,2XQ7P@28889|Crenarchaeota	28889|Crenarchaeota	Q	RNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WH3_k127_2071743_3	1121335.Clst_0952	1.395e-16	85.0	COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24U24@186801|Clostridia,3WJ3V@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
WH3_k127_2071743_2	311424.DhcVS_1236	7.314e-31	130.0	COG1040@1|root,COG1040@2|Bacteria,2G6WB@200795|Chloroflexi,34CXG@301297|Dehalococcoidia	301297|Dehalococcoidia	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_2071743_4	1173027.Mic7113_2773	2.569e-14	85.0	COG1653@1|root,COG1653@2|Bacteria,1G2C1@1117|Cyanobacteria,1HA5D@1150|Oscillatoriales	1117|Cyanobacteria	G	Carbohydrate ABC transporter substrate-binding protein, CUT1 family	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
WH3_k127_2071743_7	1464048.JNZS01000015_gene3774	1.554e-05	50.0	2EEUC@1|root,338MW@2|Bacteria,2IQC9@201174|Actinobacteria,4DFBJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TrbC
WH3_k127_2168735_3	273068.TTE1253	4.253e-46	172.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,42F33@68295|Thermoanaerobacterales	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
WH3_k127_2168735_1	429009.Adeg_1944	1.49e-139	468.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,42EM0@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
WH3_k127_2168735_10	1408423.JHYA01000005_gene1838	2.693e-07	62.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4H4XS@909932|Negativicutes	909932|Negativicutes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
WH3_k127_2168735_6	268407.PWYN_22910	1.295e-30	126.0	COG1666@1|root,COG1666@2|Bacteria,1V3UR@1239|Firmicutes,4HHVD@91061|Bacilli,26WQF@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the UPF0234 family	yitK	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
WH3_k127_2168735_0	1297581.H919_10633	2.083e-144	466.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4HAG5@91061|Bacilli,21VFN@150247|Anoxybacillus	91061|Bacilli	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
WH3_k127_2168735_7	665959.HMPREF1013_04928	1.453e-17	91.0	COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,4HJ7R@91061|Bacilli,1ZC8N@1386|Bacillus	91061|Bacilli	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
WH3_k127_2168735_12	195250.CM001776_gene2509	7.225e-05	51.0	COG1873@1|root,COG1873@2|Bacteria,1G2EH@1117|Cyanobacteria,1GZ2Y@1129|Synechococcus	1117|Cyanobacteria	S	PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
WH3_k127_2168735_8	118005.AWNK01000001_gene2037	2.213e-15	81.0	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
WH3_k127_2168735_5	706587.Desti_0332	1.613e-32	131.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2MRWY@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
WH3_k127_2168735_9	1121104.AQXH01000001_gene1515	6.395e-12	70.0	COG0238@1|root,COG0238@2|Bacteria,4NSAR@976|Bacteroidetes	976|Bacteroidetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
WH3_k127_2168735_4	1121448.DGI_0051	6.632e-41	159.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,2M9TZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
WH3_k127_2168735_2	1463901.JOIY01000046_gene3433	1.773e-125	411.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
WH3_k127_2168735_11	1296416.JACB01000094_gene2663	9.726e-07	62.0	COG1361@1|root,COG2373@1|root,COG2911@1|root,COG3291@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,4NPJI@976|Bacteroidetes,1I2IK@117743|Flavobacteriia,2YI1G@290174|Aquimarina	976|Bacteroidetes	M	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_2639847_3	395493.BegalDRAFT_2566	7.858e-56	202.0	COG0500@1|root,COG2226@2|Bacteria,1RFGA@1224|Proteobacteria,1S4V2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WH3_k127_2639847_1	1392491.JIAE01000001_gene1046	2.655e-143	464.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia,3WI84@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.132,1.1.1.136,1.1.1.22,1.1.1.336	ko:K00012,ko:K00066,ko:K02472,ko:K02474,ko:K13015	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,ko05111,map00040,map00051,map00053,map00520,map01100,map02020,map05111	M00014,M00129,M00361,M00362	R00286,R00421,R00880,R03317,R06894	RC00291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
WH3_k127_2639847_0	565034.BHWA1_01692	5.02e-168	533.0	COG0451@1|root,COG0451@2|Bacteria,2J9TK@203691|Spirochaetes	203691|Spirochaetes	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
WH3_k127_2639847_2	565034.BHWA1_01691	2.329e-70	244.0	COG1215@1|root,COG1215@2|Bacteria,2JA3U@203691|Spirochaetes	203691|Spirochaetes	H	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WH3_k127_2943697_1	926692.AZYG01000036_gene2560	2.219e-91	313.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3WB4Z@53433|Halanaerobiales	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
WH3_k127_2943697_6	1122143.AUEG01000001_gene340	1.38e-45	169.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,4HGXA@91061|Bacilli,27G9X@186828|Carnobacteriaceae	91061|Bacilli	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
WH3_k127_2943697_0	813.O172_00105	1.2e-207	679.0	COG0060@1|root,COG0060@2|Bacteria,2JFQJ@204428|Chlamydiae	204428|Chlamydiae	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
WH3_k127_2943697_2	525904.Tter_0060	1.936e-77	272.0	COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria	2|Bacteria	D	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
WH3_k127_2943697_7	525904.Tter_2736	1.746e-42	162.0	COG1525@1|root,COG1525@2|Bacteria,2NQ3M@2323|unclassified Bacteria	2|Bacteria	L	Staphylococcal nuclease homologues	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Ada_Zn_binding,SNase
WH3_k127_2943697_5	929556.Solca_0822	5.209e-55	208.0	COG0389@1|root,COG0389@2|Bacteria,4NF1Y@976|Bacteroidetes,1IP49@117747|Sphingobacteriia	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
WH3_k127_2943697_11	247490.KSU1_C0242	2.943e-06	53.0	2EJQV@1|root,33DFP@2|Bacteria,2J3W4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_2943697_4	309799.DICTH_0452	4.655e-56	203.0	COG2135@1|root,COG2135@2|Bacteria	2|Bacteria	S	peptidase activity	yoqW	-	-	-	-	-	-	-	-	-	-	-	SRAP
WH3_k127_2943697_9	1133849.O3I_029235	2.4e-16	89.0	COG3559@1|root,COG3559@2|Bacteria,2I5T7@201174|Actinobacteria,4G9V1@85025|Nocardiaceae	201174|Actinobacteria	M	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
WH3_k127_2943697_3	525904.Tter_1774	1.217e-71	254.0	COG1131@1|root,COG1131@2|Bacteria,2NNKB@2323|unclassified Bacteria	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WH3_k127_2943697_8	1151122.AQYD01000005_gene3415	8.737e-17	88.0	COG4243@1|root,COG4243@2|Bacteria,2GMVK@201174|Actinobacteria,4FQAX@85023|Microbacteriaceae	201174|Actinobacteria	S	VKc	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
WH3_k127_2943697_12	42374.XP_002422212.1	0.0002559	44.0	COG0607@1|root,KOG1530@2759|Eukaryota,3A884@33154|Opisthokonta,3P5AA@4751|Fungi,3QXJK@4890|Ascomycota,3RUU8@4891|Saccharomycetes,47EMQ@766764|Debaryomycetaceae	4751|Fungi	P	Rhodanese Homology Domain	RDL2	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005783,GO:0012505,GO:0016020,GO:0016740,GO:0016782,GO:0016783,GO:0019867,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0098588,GO:0098805	-	-	-	-	-	-	-	-	-	-	Rhodanese
WH3_k127_3266040_0	1174528.JH992898_gene4292	3.487e-19	96.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	clcD	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
WH3_k127_3266040_1	1396141.BATP01000060_gene4695	3.778e-15	86.0	COG0546@1|root,COG1051@1|root,COG0546@2|Bacteria,COG1051@2|Bacteria,46VY5@74201|Verrucomicrobia,2IUEQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,NUDIX
WH3_k127_3266040_3	1229780.BN381_70060	3.723e-05	46.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
WH3_k127_3349928_5	1128427.KB904821_gene3529	2.429e-07	64.0	COG3391@1|root,COG4932@1|root,COG3391@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	2.7.7.6	ko:K03006,ko:K13735	ko00230,ko00240,ko01100,ko03020,ko05016,ko05100,ko05168,ko05169,map00230,map00240,map01100,map03020,map05016,map05100,map05168,map05169	M00180	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	Big_1,CHU_C,DUF11,LTD,SLH,SdrD_B,fn3
WH3_k127_3349928_4	316067.Geob_3070	3.609e-33	141.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,43UK6@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
WH3_k127_3349928_0	351607.Acel_1322	1.336e-138	461.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4ES0V@85013|Frankiales	201174|Actinobacteria	NU	General secretory system II, protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
WH3_k127_3349928_1	747365.Thena_0305	4.517e-117	386.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,42F4T@68295|Thermoanaerobacterales	186801|Clostridia	NU	PFAM Type II secretion system protein E	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
WH3_k127_3349928_2	243230.DR_1863	7.875e-79	278.0	COG1459@1|root,COG1459@2|Bacteria,1WIU3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	NU	PFAM Bacterial type II secretion system protein F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
WH3_k127_3349928_3	767817.Desgi_2632	9.157e-43	167.0	COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,26256@186807|Peptococcaceae	186801|Clostridia	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
WH3_k127_3649552_2	649743.HMPREF0972_01351	2.003e-08	61.0	COG1051@1|root,COG1051@2|Bacteria,2GJGZ@201174|Actinobacteria,4D5WI@85005|Actinomycetales	201174|Actinobacteria	F	Domain of unknown function (DUF4916)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4916
WH3_k127_3649552_1	868131.MSWAN_0302	3.408e-33	133.0	COG2246@1|root,arCOG02228@2157|Archaea,2Y20I@28890|Euryarchaeota,23PR3@183925|Methanobacteria	183925|Methanobacteria	S	PFAM GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
WH3_k127_3649552_0	236814.IX39_14780	4.125e-104	342.0	COG1209@1|root,COG1209@2|Bacteria,4NE1U@976|Bacteroidetes,1HWWH@117743|Flavobacteriia,3ZPFZ@59732|Chryseobacterium	976|Bacteroidetes	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WH3_k127_372646_0	246194.CHY_1766	1.817e-155	511.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,42EP2@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
WH3_k127_372646_2	485915.Dret_0496	5.68e-05	48.0	COG2740@1|root,COG2740@2|Bacteria,1P746@1224|Proteobacteria,432JH@68525|delta/epsilon subdivisions,2WXDS@28221|Deltaproteobacteria,2MDWQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
WH3_k127_372646_1	335541.Swol_1344	2.274e-24	107.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,42JQ6@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
WH3_k127_3751194_2	309801.trd_0649	3.904e-75	263.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi,27Y1D@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
WH3_k127_3751194_1	747365.Thena_0155	9.864e-88	306.0	COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,42F9I@68295|Thermoanaerobacterales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
WH3_k127_3751194_0	592031.GCWU000322_00957	3.611e-110	381.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,25V1S@186806|Eubacteriaceae	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
WH3_k127_4135259_2	1343739.PAP_05120	7.487e-69	249.0	COG0438@1|root,arCOG01407@2157|Archaea,2XTJ5@28890|Euryarchaeota,242XN@183968|Thermococci	183968|Thermococci	M	trehalose synthase activity	treT	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
WH3_k127_4135259_6	1408422.JHYF01000019_gene1426	6.108e-36	152.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WH3_k127_4135259_5	1128421.JAGA01000001_gene2019	1.797e-50	198.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WH3_k127_4135259_9	1319815.HMPREF0202_00076	1.384e-17	87.0	COG0745@1|root,COG0745@2|Bacteria,378BX@32066|Fusobacteria	32066|Fusobacteria	K	Psort location Cytoplasmic, score 9.97	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
WH3_k127_4135259_0	316274.Haur_2832	4.533e-87	302.0	COG1626@1|root,COG1626@2|Bacteria	2|Bacteria	G	alpha,alpha-trehalase activity	treA	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100	-	R00010	RC00049	ko00000,ko00001,ko00537,ko01000	-	GH37	iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iECUMN_1333.ECUMN_1493,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245	Trehalase
WH3_k127_4135259_8	1348338.ADILRU_0708	6.863e-31	127.0	COG0526@1|root,COG0526@2|Bacteria,2GRCM@201174|Actinobacteria,4FSME@85023|Microbacteriaceae	201174|Actinobacteria	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
WH3_k127_4135259_3	1348338.ADILRU_0707	3.233e-60	216.0	COG0785@1|root,COG0785@2|Bacteria,2IK3K@201174|Actinobacteria,4FR0J@85023|Microbacteriaceae	201174|Actinobacteria	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
WH3_k127_4135259_11	1169152.AXVD01000043_gene2876	3.948e-05	52.0	COG1044@1|root,COG1044@2|Bacteria	2|Bacteria	M	lipid A biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
WH3_k127_4135259_1	255470.cbdbA734	2.334e-71	249.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2G82Q@200795|Chloroflexi,34CXZ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_4135259_7	103733.JNYO01000020_gene1953	1.203e-32	131.0	COG0681@1|root,COG0681@2|Bacteria,2IRPM@201174|Actinobacteria,4E625@85010|Pseudonocardiales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_4135259_10	1172186.KB911462_gene616	8.143e-07	59.0	29RCY@1|root,30CF4@2|Bacteria,2GW2R@201174|Actinobacteria,23BEY@1762|Mycobacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
WH3_k127_4135259_4	1379270.AUXF01000006_gene164	1.279e-50	186.0	COG1974@1|root,COG1974@2|Bacteria,1ZSSM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
WH3_k127_4155404_6	269797.Mbar_A2859	1.27e-15	80.0	COG1226@1|root,arCOG01958@2157|Archaea,2Y1ZP@28890|Euryarchaeota,2NA44@224756|Methanomicrobia	224756|Methanomicrobia	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
WH3_k127_4155404_0	269797.Mbar_A2415	3.254e-104	358.0	arCOG00142@1|root,arCOG00142@2157|Archaea,2XWCN@28890|Euryarchaeota,2NA7H@224756|Methanomicrobia	224756|Methanomicrobia	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WH3_k127_4155404_5	2055.JNXA01000003_gene4266	3.286e-18	90.0	COG4803@1|root,COG4803@2|Bacteria,2IIN1@201174|Actinobacteria,4GE4U@85026|Gordoniaceae	201174|Actinobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_4155404_3	1172185.KB911509_gene295	5.645e-22	97.0	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria,4G39Q@85025|Nocardiaceae	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
WH3_k127_4155404_4	1034347.CAHJ01000005_gene2476	1.717e-20	98.0	COG1595@1|root,COG1595@2|Bacteria,1VDSM@1239|Firmicutes,4HN8P@91061|Bacilli,1ZCXA@1386|Bacillus	91061|Bacilli	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
WH3_k127_4155404_11	983544.Lacal_1511	2.471e-05	48.0	COG0563@1|root,COG0634@1|root,COG0563@2|Bacteria,COG0634@2|Bacteria,4NG7J@976|Bacteroidetes,1HWR5@117743|Flavobacteriia	976|Bacteroidetes	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,Pribosyltran
WH3_k127_4155404_8	1047013.AQSP01000099_gene1494	9.996e-12	70.0	COG0237@1|root,COG0237@2|Bacteria	2|Bacteria	H	dephospho-CoA kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
WH3_k127_4155404_7	745776.DGo_CA2874	1.606e-14	87.0	COG0463@1|root,COG0463@2|Bacteria,1WNDV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
WH3_k127_4155404_2	446465.Bfae_04400	2.579e-60	232.0	COG0382@1|root,COG0382@2|Bacteria,2GKJ2@201174|Actinobacteria,4FDJF@85020|Dermabacteraceae	201174|Actinobacteria	H	UbiA prenyltransferase family	ubiA	-	-	ko:K20616	-	-	-	-	ko00000	-	-	-	UbiA
WH3_k127_4155404_10	744872.Spica_2299	7.015e-06	53.0	arCOG05416@1|root,2ZZTD@2|Bacteria,2JAMW@203691|Spirochaetes	203691|Spirochaetes	S	lycopene cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_4155404_9	1224164.B843_10355	4.609e-08	59.0	COG3266@1|root,COG3266@2|Bacteria,2GQFT@201174|Actinobacteria,22NVZ@1653|Corynebacteriaceae	201174|Actinobacteria	S	lycopene cyclase	crtYe	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_4155404_1	1144275.COCOR_00780	1.391e-86	298.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Phytoene dehydrogenase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
WH3_k127_416153_5	1177594.MIC448_920002	3.166e-09	59.0	2C4JB@1|root,30BI1@2|Bacteria,2GSUU@201174|Actinobacteria,4FQFT@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_416153_4	1206739.BAGJ01000135_gene640	9.275e-23	108.0	COG0631@1|root,COG0653@1|root,COG2197@1|root,COG0631@2|Bacteria,COG0653@2|Bacteria,COG2197@2|Bacteria,2I67X@201174|Actinobacteria,4FZ8D@85025|Nocardiaceae	201174|Actinobacteria	KTU	helix_turn_helix, Lux Regulon	-	-	3.5.4.40	ko:K18286	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	GerE,Glycos_transf_1,GntR,HTH_3,PP2C_2
WH3_k127_416153_0	1121288.AULL01000016_gene654	1.491e-154	497.0	COG4487@1|root,COG4487@2|Bacteria,4NFX1@976|Bacteroidetes,1HY62@117743|Flavobacteriia,3ZT3K@59732|Chryseobacterium	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2130)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
WH3_k127_416153_2	546268.NEISUBOT_05216	2.073e-100	344.0	COG4637@1|root,COG4637@2|Bacteria,1R0US@1224|Proteobacteria	1224|Proteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
WH3_k127_416153_1	929558.SMGD1_1578	1.443e-145	482.0	COG1578@1|root,COG1578@2|Bacteria,1PX2Y@1224|Proteobacteria,434B9@68525|delta/epsilon subdivisions,2YSAZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	AlwI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_AlwI
WH3_k127_416153_3	873447.SPB_1677	5.197e-65	229.0	COG0338@1|root,COG3392@1|root,COG0338@2|Bacteria,COG3392@2|Bacteria,1TRWE@1239|Firmicutes,4HD84@91061|Bacilli	91061|Bacilli	L	D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
WH3_k127_4180956_2	1341151.ASZU01000002_gene1648	7.225e-75	267.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,4HAUE@91061|Bacilli,27BCR@186824|Thermoactinomycetaceae	91061|Bacilli	L	DNA polymerase III subunits gamma and tau domain III	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
WH3_k127_4180956_5	1280390.CBQR020000145_gene3664	1.26e-60	217.0	COG1985@1|root,COG1985@2|Bacteria,1TRMH@1239|Firmicutes	1239|Firmicutes	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
WH3_k127_4180956_13	570967.JMLV01000022_gene2091	3.724e-33	134.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2JSU1@204441|Rhodospirillales	204441|Rhodospirillales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
WH3_k127_4180956_11	574087.Acear_0153	1.895e-36	144.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3WANA@53433|Halanaerobiales	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
WH3_k127_4180956_1	5722.XP_001322593.1	1.519e-88	307.0	COG0112@1|root,KOG2467@2759|Eukaryota	2759|Eukaryota	H	glycine hydroxymethyltransferase activity	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
WH3_k127_4180956_9	289377.HL41_04360	3.202e-45	179.0	COG0438@1|root,COG0438@2|Bacteria,2GHNP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WH3_k127_4180956_0	984262.SGRA_0097	6.778e-93	312.0	COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,1IRAS@117747|Sphingobacteriia	976|Bacteroidetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
WH3_k127_4180956_16	1111121.HMPREF1247_0314	3.081e-05	55.0	COG2131@1|root,COG2131@2|Bacteria,2HUU8@201174|Actinobacteria,4CVNH@84998|Coriobacteriia	84998|Coriobacteriia	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
WH3_k127_4180956_15	338969.Rfer_1209	9.782e-13	75.0	COG0537@1|root,COG0537@2|Bacteria,1N3EA@1224|Proteobacteria,2VSGA@28216|Betaproteobacteria,4AJE5@80864|Comamonadaceae	28216|Betaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	-	-	-	-	-	-	-	-	-	HIT
WH3_k127_4180956_14	224324.aq_185	3.145e-27	117.0	COG0615@1|root,COG0615@2|Bacteria,2G3YJ@200783|Aquificae	200783|Aquificae	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
WH3_k127_4180956_18	487796.Flav2ADRAFT_0622	0.0002762	52.0	COG3173@1|root,COG3173@2|Bacteria,4NFE7@976|Bacteroidetes,1I04P@117743|Flavobacteriia	976|Bacteroidetes	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
WH3_k127_4180956_8	1218108.KB908294_gene2293	5.827e-46	171.0	COG0262@1|root,COG0262@2|Bacteria,4NQ2Y@976|Bacteroidetes,1I272@117743|Flavobacteriia	976|Bacteroidetes	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	2TM,DHFR_1
WH3_k127_4180956_6	102125.Xen7305DRAFT_00016470	5.67e-57	211.0	COG0081@1|root,COG0081@2|Bacteria,1G12N@1117|Cyanobacteria,3VHUW@52604|Pleurocapsales	1117|Cyanobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
WH3_k127_4180956_10	2045.KR76_04500	8.449e-44	163.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4DQC0@85009|Propionibacteriales	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
WH3_k127_4180956_4	997296.PB1_06727	4.725e-68	235.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,4HAJA@91061|Bacilli,1ZBRH@1386|Bacillus	91061|Bacilli	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
WH3_k127_4180956_17	1392838.AWNM01000002_gene1736	0.0001351	46.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUEX@28216|Betaproteobacteria,3T4BY@506|Alcaligenaceae	28216|Betaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
WH3_k127_4180956_3	1123248.KB893348_gene317	3.911e-70	246.0	COG1562@1|root,COG1562@2|Bacteria,4NEIK@976|Bacteroidetes,1IP80@117747|Sphingobacteriia	976|Bacteroidetes	I	Squalene phytoene synthase	crtB	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
WH3_k127_4180956_7	673860.AciM339_1453	5.319e-47	183.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,3F2QZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Polyprenyl synthetase	idsA	GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
WH3_k127_4180956_12	498761.HM1_0681	2.339e-36	141.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia	186801|Clostridia	Q	FAD dependent oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
WH3_k127_418558_2	864051.BurJ1DRAFT_3700	2.095e-126	451.0	COG0726@1|root,COG0823@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3420@1|root,COG0726@2|Bacteria,COG0823@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,1MU7T@1224|Proteobacteria,2WI67@28216|Betaproteobacteria,1KMDS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MQU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
WH3_k127_418558_4	1394178.AWOO02000009_gene4252	1.361e-31	135.0	28YIC@1|root,2ZKCA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_418558_6	563037.HMPREF0850_01464	1.753e-16	94.0	COG5610@1|root,COG5610@2|Bacteria,1UYGQ@1239|Firmicutes	1239|Firmicutes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
WH3_k127_418558_5	546266.NEIMUCOT_04813	9.716e-19	94.0	COG3545@1|root,COG3545@2|Bacteria,1RKTI@1224|Proteobacteria,2VWA2@28216|Betaproteobacteria,2KS1N@206351|Neisseriales	206351|Neisseriales	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
WH3_k127_418558_3	1379698.RBG1_1C00001G1481	4.326e-90	318.0	COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria	2|Bacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
WH3_k127_418558_0	1304284.L21TH_2077	8.728e-128	419.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,36E45@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
WH3_k127_418558_1	710687.KI912270_gene3592	3.334e-127	417.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2HUK9@201174|Actinobacteria,23BT3@1762|Mycobacteriaceae	201174|Actinobacteria	LV	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
WH3_k127_4345603_2	1464048.JNZS01000015_gene3774	1.389e-06	53.0	2EEUC@1|root,338MW@2|Bacteria,2IQC9@201174|Actinobacteria,4DFBJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TrbC
WH3_k127_4345603_0	1451261.AS96_14610	1.014e-09	72.0	COG3704@1|root,COG3704@2|Bacteria	2|Bacteria	U	protein secretion by the type IV secretion system	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
WH3_k127_4345603_1	1451261.AS96_14610	6.037e-08	64.0	COG3704@1|root,COG3704@2|Bacteria	2|Bacteria	U	protein secretion by the type IV secretion system	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
WH3_k127_4422601_2	1280698.AUJS01000010_gene853	1.592e-38	162.0	COG1376@1|root,COG1376@2|Bacteria,1TQMA@1239|Firmicutes,248H0@186801|Clostridia,27VC6@189330|Dorea	186801|Clostridia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
WH3_k127_4422601_1	1047013.AQSP01000118_gene1252	2.881e-91	330.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_4422601_0	525904.Tter_0051	1.106e-243	770.0	COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
WH3_k127_4523697_1	489825.LYNGBM3L_43500	2.952e-51	189.0	COG2890@1|root,COG2890@2|Bacteria	2|Bacteria	J	protein-(glutamine-N5) methyltransferase activity	tehB	-	2.1.1.265,2.1.1.297	ko:K02493,ko:K16868	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	DUF1971,Methyltransf_23,Methyltransf_25,PrmA,TehB
WH3_k127_4523697_0	1246995.AFR_33705	7.237e-80	276.0	COG0019@1|root,COG0019@2|Bacteria,2HVQC@201174|Actinobacteria,4DHMC@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
WH3_k127_4644855_14	1408322.JHYK01000001_gene1575	2.41e-17	83.0	COG4728@1|root,COG4728@2|Bacteria	2|Bacteria	FJ	Protein conserved in bacteria	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	DUF1653
WH3_k127_4644855_17	1001240.GY21_04555	1.079e-13	76.0	2DS51@1|root,33EJB@2|Bacteria,2IM77@201174|Actinobacteria,4FPD7@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
WH3_k127_4644855_13	266117.Rxyl_0901	6.038e-18	85.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,2IH0Y@201174|Actinobacteria,4CU32@84995|Rubrobacteria	84995|Rubrobacteria	H	methylated-DNA- protein -cysteine S-methyltransferase	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1
WH3_k127_4644855_2	379066.GAU_3349	4.748e-123	399.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	xth	GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
WH3_k127_4644855_23	1123355.JHYO01000002_gene1248	1.043e-05	49.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2UF4D@28211|Alphaproteobacteria,36YRX@31993|Methylocystaceae	28211|Alphaproteobacteria	J	Ribosomal protein L33	rpmG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
WH3_k127_4644855_11	491205.JARQ01000007_gene3249	1.835e-29	126.0	COG1651@1|root,COG1651@2|Bacteria,4NQ9P@976|Bacteroidetes,1I8YG@117743|Flavobacteriia,3ZPI2@59732|Chryseobacterium	976|Bacteroidetes	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
WH3_k127_4644855_18	130081.XP_005708401.1	4.1e-11	67.0	2E3VE@1|root,2SAVA@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_4644855_4	868864.Dester_1109	8.9e-111	367.0	COG0057@1|root,COG0057@2|Bacteria,2G3TK@200783|Aquificae	200783|Aquificae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
WH3_k127_4644855_9	391037.Sare_3889	1.078e-35	141.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4DCQE@85008|Micromonosporales	201174|Actinobacteria	G	Ribose 5-phosphate isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005576,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2465c	LacAB_rpiB
WH3_k127_4644855_12	932213.SPM24T3_04037	5.368e-23	106.0	COG0036@1|root,COG0036@2|Bacteria,1RBA0@1224|Proteobacteria,1S39I@1236|Gammaproteobacteria,403SB@613|Serratia	1236|Gammaproteobacteria	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
WH3_k127_4644855_7	349161.Dred_3075	6.418e-80	276.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
WH3_k127_4644855_3	1121924.ATWH01000014_gene3393	6.751e-119	390.0	COG3958@1|root,COG3958@2|Bacteria,2I8VM@201174|Actinobacteria,4FKW5@85023|Microbacteriaceae	201174|Actinobacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
WH3_k127_4644855_24	1410653.JHVC01000005_gene2455	4.817e-05	55.0	COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,249QQ@186801|Clostridia,36G1Q@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
WH3_k127_4644855_10	349521.HCH_06817	5.452e-31	134.0	COG0524@1|root,COG0524@2|Bacteria,1QTMT@1224|Proteobacteria,1S1JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
WH3_k127_4644855_5	760568.Desku_2692	1.769e-84	290.0	COG3634@1|root,COG3634@2|Bacteria,1UIUB@1239|Firmicutes,25ES4@186801|Clostridia,267GT@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	ahpF	-	-	ko:K03387	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2,Thioredoxin_3
WH3_k127_4644855_16	203119.Cthe_0235	2.978e-16	81.0	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia	186801|Clostridia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
WH3_k127_4644855_1	926550.CLDAP_19690	3.173e-249	786.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi	200795|Chloroflexi	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
WH3_k127_4644855_0	635013.TherJR_2732	0.0	1215.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WH3_k127_4644855_6	373903.Hore_16210	2.182e-84	297.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
WH3_k127_4644855_15	511051.CSE_07330	1.41e-16	83.0	COG1950@1|root,COG1950@2|Bacteria	2|Bacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	yvlD	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
WH3_k127_4644855_20	479434.Sthe_1250	2.043e-08	58.0	COG1314@1|root,COG1314@2|Bacteria,2G7D9@200795|Chloroflexi,27YMZ@189775|Thermomicrobia	189775|Thermomicrobia	U	Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
WH3_k127_4644855_8	768670.Calni_0862	3.371e-59	226.0	COG0747@1|root,COG0747@2|Bacteria,2GEIN@200930|Deferribacteres	200930|Deferribacteres	E	Peptide nickel ABC transporter, substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WH3_k127_4644855_22	1380390.JIAT01000009_gene2243	2.833e-06	58.0	COG3409@1|root,COG3409@2|Bacteria,2HQMS@201174|Actinobacteria,4CS7D@84995|Rubrobacteria	84995|Rubrobacteria	M	Transglycosylase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Transglycosylas
WH3_k127_4644855_19	1229909.NSED_03790	5.052e-09	59.0	COG0277@1|root,arCOG00337@2157|Archaea,41T0E@651137|Thaumarchaeota	651137|Thaumarchaeota	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
WH3_k127_4759869_1	1121374.KB891575_gene1291	2.925e-22	103.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475	ACT_4,HD_4,RelA_SpoT,TGS
WH3_k127_4759869_0	525365.HMPREF0548_0946	3.214e-86	316.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9ZI@91061|Bacilli,3F4Y1@33958|Lactobacillaceae	91061|Bacilli	P	E1-E2 ATPase	aha1	-	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
WH3_k127_4759869_3	1176165.CAJD01000007_gene138	2.504e-06	56.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4F8YG@85019|Brevibacteriaceae	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
WH3_k127_4759869_2	926569.ANT_26490	3.129e-10	67.0	COG0760@1|root,COG0760@2|Bacteria,2G9A4@200795|Chloroflexi	200795|Chloroflexi	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N_3
WH3_k127_492513_1	580331.Thit_0519	1.593e-66	237.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,42EU5@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
WH3_k127_492513_0	580331.Thit_1777	3.75e-79	270.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,42EW3@68295|Thermoanaerobacterales	186801|Clostridia	D	TIGRFAM Cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
WH3_k127_492513_2	717605.Theco_0189	3.372e-38	155.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,4HA5A@91061|Bacilli,26SIG@186822|Paenibacillaceae	91061|Bacilli	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
WH3_k127_492513_3	649831.L083_2527	3.174e-10	72.0	COG3942@1|root,COG3942@2|Bacteria,2GR17@201174|Actinobacteria	201174|Actinobacteria	V	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP
WH3_k127_492513_4	1203606.HMPREF1526_02180	1.459e-05	53.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,36FVZ@31979|Clostridiaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
WH3_k127_5163350_4	273068.TTE2327	3.136e-112	375.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
WH3_k127_5163350_5	1121428.DESHY_80094___1	4.087e-109	366.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,2604E@186807|Peptococcaceae	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
WH3_k127_5163350_12	1095750.HMPREF9970_2183	5.709e-17	85.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,1HVVS@1164882|Lachnoanaerobaculum	186801|Clostridia	L	Uncharacterised protein family UPF0102	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
WH3_k127_5163350_10	1408321.JNJD01000006_gene782	1.005e-28	123.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,27N93@186928|unclassified Lachnospiraceae	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
WH3_k127_5163350_0	1122217.KB899576_gene1870	1.095e-305	976.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,4H2CW@909932|Negativicutes	909932|Negativicutes	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
WH3_k127_5163350_18	1042163.BRLA_c035310	0.0001219	48.0	2EAMZ@1|root,334QH@2|Bacteria,1VGIW@1239|Firmicutes,4HPFD@91061|Bacilli,26XNT@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_5163350_16	1033743.CAES01000061_gene4483	1.943e-09	65.0	COG4980@1|root,COG4980@2|Bacteria,1VFY7@1239|Firmicutes,4HNWV@91061|Bacilli,26ZTC@186822|Paenibacillaceae	91061|Bacilli	S	general stress protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
WH3_k127_5163350_15	485914.Hmuk_0588	1.386e-13	78.0	COG0668@1|root,arCOG01568@2157|Archaea,2XX3I@28890|Euryarchaeota,23VP3@183963|Halobacteria	183963|Halobacteria	M	Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
WH3_k127_5163350_3	935845.JADQ01000054_gene3554	6.814e-137	451.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,26R27@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
WH3_k127_5163350_2	272134.KB731324_gene3457	2.876e-141	463.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,1H6YQ@1150|Oscillatoriales	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
WH3_k127_5163350_13	1304284.L21TH_1654	3.553e-16	81.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,36MP3@31979|Clostridiaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
WH3_k127_5163350_1	1347087.CBYO010000001_gene120	1.204e-165	546.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli	91061|Bacilli	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
WH3_k127_5163350_6	1047013.AQSP01000139_gene2394	5.96e-79	273.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
WH3_k127_5163350_11	525373.HMPREF0766_12120	1.42e-19	96.0	COG0572@1|root,COG0572@2|Bacteria,4NEEC@976|Bacteroidetes,1IRQM@117747|Sphingobacteriia	976|Bacteroidetes	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
WH3_k127_5163350_9	1123013.AUIC01000003_gene772	2.141e-58	208.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4FK45@85023|Microbacteriaceae	201174|Actinobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
WH3_k127_5163350_14	391625.PPSIR1_29343	2.167e-15	85.0	COG5523@1|root,COG5523@2|Bacteria,1PVR8@1224|Proteobacteria,434AQ@68525|delta/epsilon subdivisions,2WZ03@28221|Deltaproteobacteria,2Z11H@29|Myxococcales	28221|Deltaproteobacteria	J	Uncharacterised protein family (UPF0259)	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_5163350_7	525365.HMPREF0548_0820	2.981e-66	235.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,4H9Q6@91061|Bacilli,3F46A@33958|Lactobacillaceae	91061|Bacilli	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
WH3_k127_5163350_8	649638.Trad_0463	1.113e-60	226.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1WIPW@1297|Deinococcus-Thermus	2|Bacteria	C	PFAM FAD linked oxidase domain protein	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
WH3_k127_5230193_10	926554.KI912675_gene2279	2.571e-12	70.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.57,2.3.1.82	ko:K00657,ko:K00663	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Acetyltransf_3,Acetyltransf_8
WH3_k127_5230193_8	877455.Metbo_1987	1.502e-16	85.0	COG0494@1|root,arCOG01078@2157|Archaea,2Y05V@28890|Euryarchaeota,23PUC@183925|Methanobacteria	183925|Methanobacteria	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WH3_k127_5230193_14	290317.Cpha266_1634	1.119e-05	52.0	2E3Q3@1|root,32YN2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_5230193_1	1353276.JADR01000002_gene2031	4.93e-82	295.0	COG1132@1|root,COG1132@2|Bacteria,4NHI1@976|Bacteroidetes,1HX07@117743|Flavobacteriia	976|Bacteroidetes	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WH3_k127_5230193_2	1122147.AUEH01000047_gene2951	4.329e-63	227.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,4H9Q7@91061|Bacilli,3F43E@33958|Lactobacillaceae	91061|Bacilli	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
WH3_k127_5230193_4	1137281.D778_02353	2.334e-34	136.0	COG2827@1|root,COG2827@2|Bacteria,4NUYX@976|Bacteroidetes,1I4M9@117743|Flavobacteriia	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
WH3_k127_5230193_6	1280676.AUJO01000003_gene35	8.651e-23	109.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,4BX93@830|Butyrivibrio	186801|Clostridia	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
WH3_k127_5230193_13	1278073.MYSTI_05200	2.622e-09	63.0	COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2WR9I@28221|Deltaproteobacteria,2YW1W@29|Myxococcales	28221|Deltaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
WH3_k127_5230193_7	1137799.GZ78_13785	3.005e-17	91.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,1RS6X@1236|Gammaproteobacteria,1XITG@135619|Oceanospirillales	135619|Oceanospirillales	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
WH3_k127_5230193_12	1408823.AXUS01000004_gene260	1.911e-09	69.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,25R43@186804|Peptostreptococcaceae	186801|Clostridia	S	DHHA1 domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WH3_k127_5230193_11	880073.Calab_3224	2.218e-11	69.0	2CCSR@1|root,32RWC@2|Bacteria	2|Bacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
WH3_k127_5230193_3	1444711.CCJF01000005_gene1740	1.241e-48	181.0	COG0130@1|root,COG0130@2|Bacteria,2JFXN@204428|Chlamydiae	204428|Chlamydiae	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
WH3_k127_5230193_5	552398.HMPREF0866_02326	5.572e-26	109.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,3WK6U@541000|Ruminococcaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
WH3_k127_5230193_0	373903.Hore_07900	2.274e-212	679.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,3WAD8@53433|Halanaerobiales	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
WH3_k127_5596729_4	526224.Bmur_1644	8.846e-32	128.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
WH3_k127_5596729_5	85643.Tmz1t_2648	6.042e-09	64.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
WH3_k127_5596729_1	1121938.AUDY01000012_gene3590	1.054e-63	224.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,4HAZR@91061|Bacilli,3NEJV@45667|Halobacillus	91061|Bacilli	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
WH3_k127_5596729_6	1121447.JONL01000001_gene381	1.604e-06	54.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,42TGQ@68525|delta/epsilon subdivisions,2WQ6R@28221|Deltaproteobacteria,2MCHW@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
WH3_k127_5596729_0	1042209.HK44_017325	1.167e-76	275.0	COG5305@1|root,COG5305@2|Bacteria,1R9UF@1224|Proteobacteria,1S0JK@1236|Gammaproteobacteria,1YMK4@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
WH3_k127_5596729_2	1499967.BAYZ01000017_gene6259	1.089e-40	160.0	COG1215@1|root,COG1215@2|Bacteria,2NPW4@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WH3_k127_5596729_3	941449.dsx2_1679	1.051e-35	154.0	COG4745@1|root,COG4745@2|Bacteria	2|Bacteria	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
WH3_k127_5596729_7	411467.BACCAP_01292	3.041e-06	56.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
WH3_k127_5771590_0	1227268.HMPREF1552_01808	3.963e-70	253.0	COG2812@1|root,COG2812@2|Bacteria,378A7@32066|Fusobacteria	32066|Fusobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
WH3_k127_5823526_4	1188235.MBVG_3470	4.811e-06	54.0	COG0228@1|root,COG0228@2|Bacteria,3WTVG@544448|Tenericutes	544448|Tenericutes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
WH3_k127_5823526_1	717231.Flexsi_1964	3.028e-15	81.0	COG1837@1|root,COG1837@2|Bacteria,2GFZI@200930|Deferribacteres	200930|Deferribacteres	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
WH3_k127_5823526_0	1384057.CD33_17825	3.43e-78	267.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,3IWAZ@400634|Lysinibacillus	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
WH3_k127_5823526_3	1201293.AKXQ01000014_gene4140	6.301e-09	65.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
WH3_k127_5823526_2	877455.Metbo_0227	2.024e-11	72.0	arCOG11916@1|root,arCOG11916@2157|Archaea	2157|Archaea	S	Sap, sulfolipid-1-addressing protein	-	-	-	-	-	-	-	-	-	-	-	-	SfLAP
WH3_k127_63222_0	1268303.RHODMAR_1212	1.812e-130	427.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4FVTD@85025|Nocardiaceae	201174|Actinobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
WH3_k127_63222_1	1123360.thalar_02462	1.626e-15	83.0	COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,2U93B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
WH3_k127_6403097_3	1121087.AUCK01000014_gene329	0.0007338	47.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,4HFX9@91061|Bacilli,1ZFW8@1386|Bacillus	91061|Bacilli	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
WH3_k127_6403097_1	309799.DICTH_1273	7.639e-97	330.0	COG0172@1|root,COG0172@2|Bacteria	2|Bacteria	J	seryl-tRNA aminoacylation	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
WH3_k127_6403097_0	1173025.GEI7407_3640	2.084e-124	415.0	COG1190@1|root,COG1190@2|Bacteria,1G0SA@1117|Cyanobacteria,1H95W@1150|Oscillatoriales	1117|Cyanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iJN678.lysS	KTSC,tRNA-synt_2,tRNA_anti-codon
WH3_k127_6403097_2	1203606.HMPREF1526_02177	8.923e-13	68.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,36HY8@31979|Clostridiaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
WH3_k127_6565913_2	1329516.JPST01000003_gene1138	5.559e-66	241.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,4H9Q8@91061|Bacilli,27B4Z@186824|Thermoactinomycetaceae	91061|Bacilli	O	Bacterial trigger factor protein (TF) C-terminus	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
WH3_k127_6565913_0	452652.KSE_28790	2.264e-161	518.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,2M0FB@2063|Kitasatospora	201174|Actinobacteria	M	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
WH3_k127_6565913_3	1037410.MCSF7_00045	6.224e-30	125.0	COG0742@1|root,COG0742@2|Bacteria,3WTBQ@544448|Tenericutes	544448|Tenericutes	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
WH3_k127_6565913_1	311424.DhcVS_1196	1.361e-132	437.0	COG0034@1|root,COG0034@2|Bacteria,2G61T@200795|Chloroflexi,34CJ3@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
WH3_k127_7213173_0	653733.Selin_1951	3.683e-189	597.0	COG0050@1|root,COG0050@2|Bacteria	2|Bacteria	J	translation elongation factor activity	tuf	GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0016020,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0044003,GO:0044068,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071944,GO:0090087,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484	-	ko:K02358,ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	3.A.1.1.16,3.A.1.1.2	-	iSB619.SA_RS02960	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
WH3_k127_7213173_1	1121472.AQWN01000002_gene2039	7.687e-41	154.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,2620M@186807|Peptococcaceae	186801|Clostridia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WH3_k127_7352515_3	1031288.AXAA01000029_gene48	2.925e-12	80.0	COG1305@1|root,COG5492@1|root,COG1305@2|Bacteria,COG5492@2|Bacteria,1VBT6@1239|Firmicutes,25B2B@186801|Clostridia,36W8H@31979|Clostridiaceae	186801|Clostridia	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Flg_new
WH3_k127_7352515_0	1304888.ATWF01000001_gene2187	5.402e-124	413.0	COG0143@1|root,COG0143@2|Bacteria,2GF31@200930|Deferribacteres	200930|Deferribacteres	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
WH3_k127_7352515_4	269797.Mbar_A3000	5.243e-05	51.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2Y48Z@28890|Euryarchaeota,2NAZS@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
WH3_k127_7352515_2	445971.ANASTE_02247	1.057e-49	187.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,25V0F@186806|Eubacteriaceae	186801|Clostridia	L	hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WH3_k127_7352515_1	350688.Clos_1670	1.356e-57	210.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36DXY@31979|Clostridiaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
WH3_k127_7539364_0	2325.TKV_c14060	1.138e-154	511.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,42ES5@68295|Thermoanaerobacterales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
WH3_k127_7977772_1	1123399.AQVE01000007_gene1186	1.275e-20	94.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,45ZSX@72273|Thiotrichales	72273|Thiotrichales	NU	Type II IV secretion system protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
WH3_k127_7977772_0	1517416.IDAT_05120	2.238e-26	122.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,2QGRY@267893|Idiomarinaceae	1236|Gammaproteobacteria	U	type II secretion system protein F	pilC	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009297,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0032940,GO:0033036,GO:0042886,GO:0043711,GO:0044085,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0098776	-	ko:K02505,ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
WH3_k127_8070702_5	525904.Tter_1611	1.513e-08	61.0	COG2348@1|root,COG2348@2|Bacteria	2|Bacteria	V	transferase activity, transferring amino-acyl groups	murM	-	2.3.2.10,2.3.2.16,2.3.2.17,2.3.2.18	ko:K05363,ko:K11693,ko:K11694,ko:K11695,ko:K12554,ko:K18354	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	R08776,R08777,R08778,R08779,R08780	RC00055,RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	FemAB
WH3_k127_8070702_4	1312959.KI914647_gene188	2.618e-49	188.0	COG2348@1|root,COG2348@2|Bacteria,2HURK@201174|Actinobacteria,1W7J3@1268|Micrococcaceae	201174|Actinobacteria	V	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
WH3_k127_8070702_2	688269.Theth_0359	1.932e-89	306.0	COG0533@1|root,COG0533@2|Bacteria,2GCC5@200918|Thermotogae	200918|Thermotogae	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WH3_k127_8070702_0	1089553.Tph_c04910	6.361e-188	614.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,42ET0@68295|Thermoanaerobacterales	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
WH3_k127_8070702_3	188626.HMPREF0321_0780	3.165e-70	250.0	COG0330@1|root,COG0330@2|Bacteria,2GPA3@201174|Actinobacteria	201174|Actinobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
WH3_k127_8070702_7	1168059.KB899087_gene1061	3.97e-06	49.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
WH3_k127_8070702_1	1032480.MLP_03890	4.367e-109	368.0	COG0152@1|root,COG0152@2|Bacteria	2|Bacteria	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464	4.1.1.21,4.3.2.2,6.3.2.6	ko:K01587,ko:K01756,ko:K01923	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04209,R04559,R04591	RC00064,RC00162,RC00379,RC00444,RC00445,RC00590	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735	SAICAR_synt
WH3_k127_8070702_6	410358.Mlab_0209	3.38e-08	66.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
WH3_k127_8070702_8	68170.KL590518_gene103	0.0003189	45.0	COG3847@1|root,COG3847@2|Bacteria,2GX2Y@201174|Actinobacteria	201174|Actinobacteria	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
WH3_k127_8105962_0	926692.AZYG01000064_gene1036	3.12e-77	270.0	COG0849@1|root,COG0849@2|Bacteria,1UD79@1239|Firmicutes,25HUK@186801|Clostridia,3WBK1@53433|Halanaerobiales	186801|Clostridia	D	Cell division protein FtsA	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
WH3_k127_8105962_1	1499968.TCA2_0163	3.163e-08	63.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,4HCEX@91061|Bacilli,26TRP@186822|Paenibacillaceae	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06365	CDP-OH_P_transf
WH3_k127_8215390_4	311424.DhcVS_347	6.275e-28	117.0	COG0030@1|root,COG0030@2|Bacteria,2G6ER@200795|Chloroflexi,34CIF@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
WH3_k127_8215390_3	28042.GU90_04085	1.002e-32	141.0	COG3583@1|root,COG3583@2|Bacteria,2H4RU@201174|Actinobacteria,4DXKM@85010|Pseudonocardiales	201174|Actinobacteria	G	G5	rpfB	GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0009893,GO:0010468,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019222,GO:0022611,GO:0032502,GO:0040008,GO:0040009,GO:0040010,GO:0044111,GO:0044114,GO:0044115,GO:0044403,GO:0044419,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0051704,GO:0060255,GO:0065007,GO:0085016	-	ko:K21688	-	-	-	-	ko00000	-	-	-	DUF348,G5,Transglycosylas
WH3_k127_8215390_0	498761.HM1_3029	4.948e-198	639.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia	186801|Clostridia	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
WH3_k127_8215390_1	485913.Krac_0827	5.526e-50	184.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,TehB
WH3_k127_8215390_2	1173263.Syn7502_03325	3.695e-38	149.0	COG0221@1|root,COG0221@2|Bacteria,1G1Q3@1117|Cyanobacteria,1GZGC@1129|Synechococcus	1117|Cyanobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
WH3_k127_8215390_5	1449044.JMLE01000001_gene4092	5.857e-24	104.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,1W7VR@1268|Micrococcaceae	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
WH3_k127_8392674_5	883114.HMPREF9709_00726	2.157e-28	124.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,22HAY@1570339|Peptoniphilaceae	186801|Clostridia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
WH3_k127_8392674_8	1449063.JMLS01000023_gene2831	1.557e-22	104.0	COG0500@1|root,COG0500@2|Bacteria,1V4RN@1239|Firmicutes,4HHFD@91061|Bacilli,274IQ@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
WH3_k127_8392674_0	928724.SacglDRAFT_00916	3.096e-148	482.0	COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DYBE@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
WH3_k127_8392674_1	933262.AXAM01000081_gene2264	3.634e-117	388.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,2MHX3@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
WH3_k127_8392674_13	1206730.BAGA01000175_gene6157	9.668e-06	53.0	COG1011@1|root,COG1011@2|Bacteria,2IN1K@201174|Actinobacteria	201174|Actinobacteria	S	HAD-superfamily hydrolase subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
WH3_k127_8392674_4	365046.Rta_20180	1.899e-45	167.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,4AE0C@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
WH3_k127_8392674_9	1121356.AQUW01000008_gene703	7.843e-18	91.0	COG0243@1|root,COG0243@2|Bacteria,2GJ62@201174|Actinobacteria,22MQ1@1653|Corynebacteriaceae	201174|Actinobacteria	C	molybdopterin cofactor binding	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
WH3_k127_8392674_10	679926.Mpet_2586	1.638e-17	84.0	COG0550@1|root,arCOG06233@2157|Archaea	2157|Archaea	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
WH3_k127_8392674_2	269797.Mbar_A2077	4.338e-89	301.0	COG0655@1|root,arCOG02578@2157|Archaea,2Y5KU@28890|Euryarchaeota,2NBE4@224756|Methanomicrobia	224756|Methanomicrobia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
WH3_k127_8392674_3	1329516.JPST01000035_gene3113	8.586e-61	213.0	COG0225@1|root,COG0225@2|Bacteria,1V4HF@1239|Firmicutes,4HHQM@91061|Bacilli,27BQ3@186824|Thermoactinomycetaceae	91061|Bacilli	O	Peptide methionine sulfoxide reductase	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
WH3_k127_8392674_14	224325.AF_1598	1.327e-05	53.0	arCOG06137@1|root,arCOG06137@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4234)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4234
WH3_k127_8392674_15	1408415.JHXL01000006_gene115	0.0009742	51.0	COG0457@1|root,COG0457@2|Bacteria,3WUQZ@544448|Tenericutes	544448|Tenericutes	S	Protein of unknown function (DUF3137)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3137
WH3_k127_8392674_11	411154.GFO_0322	4.525e-10	63.0	COG3205@1|root,COG3205@2|Bacteria,4NV6E@976|Bacteroidetes,1I4TA@117743|Flavobacteriia	976|Bacteroidetes	S	Predicted membrane protein (DUF2061)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2061
WH3_k127_8392674_7	1121930.AQXG01000008_gene203	8.788e-27	112.0	COG4912@1|root,COG4912@2|Bacteria,4NKBS@976|Bacteroidetes,1IX96@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
WH3_k127_8401121_2	867845.KI911784_gene2059	4.26e-47	177.0	COG0265@1|root,COG0265@2|Bacteria,2G6KV@200795|Chloroflexi,375DX@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
WH3_k127_8401121_1	273068.TTE0142	6.176e-49	185.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,42F18@68295|Thermoanaerobacterales	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
WH3_k127_8401121_0	555079.Toce_2072	4.398e-53	190.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
WH3_k127_8401755_1	1278073.MYSTI_04345	1.017e-59	222.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WH3_k127_8401755_0	1120972.AUMH01000012_gene39	5.395e-225	731.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,2786V@186823|Alicyclobacillaceae	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
WH3_k127_8401755_2	1293054.HSACCH_01377	9.83e-07	56.0	COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia,3WATW@53433|Halanaerobiales	186801|Clostridia	S	metal-binding, possibly nucleic acid-binding protein	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
WH3_k127_8622988_4	1341151.ASZU01000006_gene2792	6.706e-59	210.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,4HA2M@91061|Bacilli,27B7C@186824|Thermoactinomycetaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
WH3_k127_8622988_3	555088.DealDRAFT_3034	1.645e-62	220.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,25MYX@186801|Clostridia,42KTR@68298|Syntrophomonadaceae	186801|Clostridia	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
WH3_k127_8622988_8	403833.Pmob_0089	3.854e-16	85.0	COG2265@1|root,COG2265@2|Bacteria	2|Bacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	trmA	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	TRAM,tRNA_U5-meth_tr
WH3_k127_8622988_6	1144275.COCOR_07182	9.504e-43	161.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WH3_k127_8622988_7	945713.IALB_2257	3.513e-38	152.0	COG3298@1|root,COG3298@2|Bacteria	2|Bacteria	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	wlaX	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
WH3_k127_8622988_1	402881.Plav_2485	2.324e-100	340.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,1JNCZ@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	DEAD-like helicases superfamily	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
WH3_k127_8622988_2	467200.ACFA01000004_gene1804	4.587e-70	246.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992,ko:K18233	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC2_membrane
WH3_k127_8622988_0	465541.ATCJ01000005_gene5033	4.4e-102	342.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WH3_k127_8622988_9	1121022.ABENE_01035	1.25e-09	68.0	COG5661@1|root,COG5661@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF922
WH3_k127_8622988_13	1499967.BAYZ01000045_gene2651	9.255e-05	51.0	COG2110@1|root,COG2110@2|Bacteria,2NPPR@2323|unclassified Bacteria	2|Bacteria	S	Appr-1'-p processing enzyme	ymdB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Macro,VWA
WH3_k127_8622988_5	1123237.Salmuc_00701	3.292e-43	163.0	arCOG05193@1|root,2ZZSG@2|Bacteria,1REJB@1224|Proteobacteria,2U7D9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_8622988_10	156889.Mmc1_3654	5.87e-09	60.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the UPF0235 family	yggU	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
WH3_k127_8622988_11	1123248.KB893319_gene4004	1.271e-07	55.0	2BZQY@1|root,2ZVH4@2|Bacteria,4P73I@976|Bacteroidetes,1IZGJ@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_8622988_12	1080067.BAZH01000008_gene77	2.409e-05	48.0	2AYT6@1|root,31QYG@2|Bacteria,1QNH4@1224|Proteobacteria,1TM2S@1236|Gammaproteobacteria,3WZPT@544|Citrobacter	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_88345_5	639282.DEFDS_0358	6.732e-10	61.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
WH3_k127_88345_1	272563.CD630_17350	9.934e-30	127.0	COG1011@1|root,COG1011@2|Bacteria,1TRQ6@1239|Firmicutes,25B04@186801|Clostridia	186801|Clostridia	S	hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
WH3_k127_88345_3	266779.Meso_1517	1.858e-17	94.0	COG1361@1|root,COG4719@1|root,COG1361@2|Bacteria,COG4719@2|Bacteria,1R59C@1224|Proteobacteria,2TUS0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
WH3_k127_88345_2	265729.GS18_0200975	2.86e-25	114.0	COG3764@1|root,COG3764@2|Bacteria,1V79B@1239|Firmicutes,4HJ8C@91061|Bacilli,1ZHDM@1386|Bacillus	91061|Bacilli	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
WH3_k127_88345_0	35754.JNYJ01000011_gene731	8.292e-57	214.0	COG2898@1|root,COG2898@2|Bacteria,2I2ZR@201174|Actinobacteria,4DBVQ@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3,6.1.1.6	ko:K04567,ko:K14205	ko00970,ko01503,ko02020,ko05150,map00970,map01503,map02020,map05150	M00359,M00360,M00726	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko01504,ko03016	2.A.1.3.37	-	-	DUF2156,tRNA-synt_2_TM
WH3_k127_88345_6	1121428.DESHY_40183___1	0.0001663	49.0	COG2919@1|root,COG2919@2|Bacteria,1VKC5@1239|Firmicutes,24UDF@186801|Clostridia	186801|Clostridia	D	septum formation initiator	-	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
WH3_k127_8844656_0	247490.KSU1_D0384	3.444e-235	754.0	COG0653@1|root,COG0653@2|Bacteria,2IXIT@203682|Planctomycetes	203682|Planctomycetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
WH3_k127_9147948_7	483218.BACPEC_00937	1.982e-18	94.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,267M7@186813|unclassified Clostridiales	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
WH3_k127_9147948_5	768706.Desor_5009	1.005e-25	113.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,26214@186807|Peptococcaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
WH3_k127_9147948_0	879212.DespoDRAFT_00469	8.63e-248	781.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
WH3_k127_9147948_6	660470.Theba_2314	5.391e-20	94.0	COG0399@1|root,COG0399@2|Bacteria,2GE6C@200918|Thermotogae	200918|Thermotogae	J	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
WH3_k127_9147948_8	457570.Nther_2275	1.205e-08	65.0	COG1432@1|root,COG1432@2|Bacteria,1V1JD@1239|Firmicutes,24V8S@186801|Clostridia	186801|Clostridia	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
WH3_k127_9147948_2	626939.HMPREF9443_00734	1.124e-63	229.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H28A@909932|Negativicutes	909932|Negativicutes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
WH3_k127_9147948_9	865937.Gilli_3106	4.446e-06	59.0	COG3930@1|root,COG3930@2|Bacteria,4NG5D@976|Bacteroidetes,1HZIT@117743|Flavobacteriia,2P7B4@244698|Gillisia	976|Bacteroidetes	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
WH3_k127_9147948_3	1278073.MYSTI_04345	2.861e-62	230.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WH3_k127_9147948_4	1305737.JAFX01000001_gene1951	1.379e-26	114.0	COG4067@1|root,COG4067@2|Bacteria,4NS86@976|Bacteroidetes,47RH0@768503|Cytophagia	976|Bacteroidetes	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
WH3_k127_9147948_1	1121104.AQXH01000001_gene1058	2.668e-108	358.0	COG0189@1|root,COG0189@2|Bacteria,4NED4@976|Bacteroidetes,1IRHK@117747|Sphingobacteriia	976|Bacteroidetes	HJ	Belongs to the RimK family	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
WH3_k127_9147948_10	1286106.MPL1_02908	1.86e-05	52.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,4600T@72273|Thiotrichales	72273|Thiotrichales	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
WH3_k127_9212231_0	68194.JNXR01000001_gene6734	7.834e-62	217.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
WH3_k127_9212231_2	1120973.AQXL01000104_gene2586	1.373e-08	64.0	COG1814@1|root,COG1814@2|Bacteria,1V011@1239|Firmicutes,4HWJY@91061|Bacilli,278XW@186823|Alicyclobacillaceae	91061|Bacilli	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
WH3_k127_9212231_1	1280686.AUKE01000016_gene945	2.37e-10	66.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,4BZ3R@830|Butyrivibrio	186801|Clostridia	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
WH3_k127_9212231_3	264732.Moth_0835	2.493e-07	54.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,42EWY@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
WH3_k127_9223980_1	118168.MC7420_848	1.531e-61	220.0	COG1052@1|root,COG1052@2|Bacteria,1G028@1117|Cyanobacteria,1H7XD@1150|Oscillatoriales	1117|Cyanobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
WH3_k127_9223980_4	208439.AJAP_16315	1.27e-09	64.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
WH3_k127_9223980_3	406124.ACPC01000046_gene2356	2.152e-28	122.0	COG3764@1|root,COG3764@2|Bacteria,1V79B@1239|Firmicutes,4HJ8C@91061|Bacilli,1ZHDM@1386|Bacillus	91061|Bacilli	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
WH3_k127_9223980_2	469383.Cwoe_3142	5.099e-44	171.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria,4CSJH@84995|Rubrobacteria	84995|Rubrobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3494
WH3_k127_9223980_0	5693.XP_811679.1	6.308e-103	348.0	COG0461@1|root,KOG1377@2759|Eukaryota,3XSWC@5653|Kinetoplastida	5653|Kinetoplastida	F	Orotidine-5-phosphate decarboxylase orotate phosphoribosyltransferase	-	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
WH3_k127_9251492_1	552811.Dehly_0104	3.226e-81	283.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi,34D8Y@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
WH3_k127_9251492_0	637389.Acaty_m0138	1.435e-116	381.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,2NBZD@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
WH3_k127_9499272_2	714943.Mucpa_0971	1.125e-19	91.0	COG1308@1|root,COG1308@2|Bacteria,4NVAE@976|Bacteroidetes,1IZ5E@117747|Sphingobacteriia	976|Bacteroidetes	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
WH3_k127_9499272_5	867900.Celly_0305	1.016e-10	73.0	COG1443@1|root,COG1443@2|Bacteria,4NRS2@976|Bacteroidetes,1I2UY@117743|Flavobacteriia,1F98W@104264|Cellulophaga	976|Bacteroidetes	I	SPTR Hydrolase of MutT (Nudix) family protein	idi	-	-	-	-	-	-	-	-	-	-	-	NUDIX
WH3_k127_9499272_1	1121924.ATWH01000006_gene1911	4.112e-27	118.0	COG3548@1|root,COG3548@2|Bacteria,2IQG2@201174|Actinobacteria,4FPAK@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
WH3_k127_9499272_3	1192034.CAP_1962	9.434e-14	82.0	COG3344@1|root,COG3344@2|Bacteria,1R44F@1224|Proteobacteria,42WGB@68525|delta/epsilon subdivisions,2WQ7V@28221|Deltaproteobacteria,2YZ1Y@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	RVT_1
WH3_k127_9499272_4	1206735.BAGG01000088_gene3587	1.198e-11	65.0	2EJRI@1|root,33DGB@2|Bacteria,2ISBS@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WH3_k127_9695637_6	648885.KB316282_gene1434	1.258e-28	118.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2TRTV@28211|Alphaproteobacteria,1JTP8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PFAM Circadian clock protein KaiC central region	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
WH3_k127_9695637_5	1173025.GEI7407_2475	8.299e-56	202.0	COG0275@1|root,COG0275@2|Bacteria,1G0AR@1117|Cyanobacteria,1H8QI@1150|Oscillatoriales	1117|Cyanobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
WH3_k127_9695637_1	525904.Tter_1614	7.422e-101	349.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PASTA,PBP_dimer,Transpeptidase
WH3_k127_9695637_4	649747.HMPREF0083_05013	6.66e-58	214.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,4H9TP@91061|Bacilli,26RV6@186822|Paenibacillaceae	91061|Bacilli	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
WH3_k127_9695637_2	1196028.ALEF01000054_gene3728	1.58e-83	291.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4HAEV@91061|Bacilli,4C4IT@84406|Virgibacillus	91061|Bacilli	D	Cell cycle protein	spoVE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
WH3_k127_9695637_3	1410624.JNKK01000042_gene1180	3.526e-69	250.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,27INU@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
WH3_k127_9695637_7	1236908.wNo_10400	0.0001774	52.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,47FI0@766|Rickettsiales	766|Rickettsiales	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
WH3_k127_9695637_0	1047013.AQSP01000118_gene1252	2.139e-129	428.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_9847959_3	1033810.HLPCO_001528	1.101e-10	64.0	COG1847@1|root,COG1847@2|Bacteria,2NQ3F@2323|unclassified Bacteria	2|Bacteria	S	Jag_N	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
WH3_k127_9847959_0	596315.HMPREF0634_0211	6.202e-84	295.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,25QGZ@186804|Peptostreptococcaceae	186801|Clostridia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
WH3_k127_9847959_2	383372.Rcas_0036	1.883e-52	206.0	COG2720@1|root,COG2720@2|Bacteria,2G67R@200795|Chloroflexi,3769S@32061|Chloroflexia	32061|Chloroflexia	V	PFAM VanW family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
WH3_k127_9847959_1	1380356.JNIK01000011_gene2046	3.286e-60	211.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4EUYD@85013|Frankiales	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
WH3_k127_9900678_3	1464048.JNZS01000007_gene4409	2.079e-41	156.0	COG4912@1|root,COG4912@2|Bacteria,2ID3C@201174|Actinobacteria	201174|Actinobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
WH3_k127_9900678_4	485913.Krac_12335	9.971e-35	150.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
WH3_k127_9900678_0	439292.Bsel_0570	8.479e-85	291.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4HA9K@91061|Bacilli,26NDB@186821|Sporolactobacillaceae	91061|Bacilli	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	-	-	-	-	-	-	-	-	-	Dus
WH3_k127_9900678_7	123214.PERMA_1224	0.0003516	49.0	COG0202@1|root,COG0202@2|Bacteria,2G3IG@200783|Aquificae	200783|Aquificae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
WH3_k127_9900678_6	767029.HMPREF9154_0545	2.002e-11	70.0	COG0526@1|root,COG0526@2|Bacteria,2GRCM@201174|Actinobacteria,4DW54@85009|Propionibacteriales	201174|Actinobacteria	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
WH3_k127_9900678_5	552811.Dehly_0503	3.336e-30	123.0	COG5580@1|root,COG5580@2|Bacteria	2|Bacteria	O	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
WH3_k127_9900678_1	1341151.ASZU01000026_gene1156	1.11e-67	240.0	COG1054@1|root,COG1054@2|Bacteria,1TRG7@1239|Firmicutes,4HA0J@91061|Bacilli,27BP1@186824|Thermoactinomycetaceae	91061|Bacilli	S	Rhodanase C-terminal	ybfQ	-	-	ko:K07146	-	-	-	-	ko00000	-	-	-	Rhodanese,Rhodanese_C
WH3_k127_9900678_2	485913.Krac_6741	3.976e-62	231.0	COG0769@1|root,COG0769@2|Bacteria,2G5U3@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WH3_k127_9946291_0	1321779.HMPREF1984_00071	4.843e-123	408.0	COG0338@1|root,COG3392@1|root,COG0338@2|Bacteria,COG3392@2|Bacteria,37BTI@32066|Fusobacteria	32066|Fusobacteria	H	Site-specific DNA-methyltransferase (Adenine-specific)	dam	-	2.1.1.72	ko:K06223,ko:K07318	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
WH3_k127_9946291_9	1123354.AUDR01000013_gene569	1.019e-16	85.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,1KS73@119069|Hydrogenophilales	119069|Hydrogenophilales	T	cheY-homologous receiver domain	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
WH3_k127_9946291_6	1347086.CCBA010000023_gene2214	5.827e-29	119.0	COG1694@1|root,COG1694@2|Bacteria,1VA3E@1239|Firmicutes,4HKDQ@91061|Bacilli,1ZI1C@1386|Bacillus	91061|Bacilli	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
WH3_k127_9946291_7	653386.HMPREF0975_01127	7.7e-29	120.0	2BPN1@1|root,32IF3@2|Bacteria,2HM7R@201174|Actinobacteria,4D6HS@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_9946291_10	1416759.AYMR01000007_gene686	1.422e-14	78.0	2A1Z3@1|root,30Q8Q@2|Bacteria,2GZRX@201174|Actinobacteria,4FQ9F@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_9946291_1	926554.KI912664_gene1569	1.497e-74	263.0	COG1506@1|root,COG1506@2|Bacteria,1WNJA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
WH3_k127_9946291_12	641524.ADICYQ_0130	2.232e-10	65.0	2E4BN@1|root,32Z79@2|Bacteria,4NXNH@976|Bacteroidetes,47VXU@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WH3_k127_9946291_2	1158607.UAU_00890	5.808e-67	236.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HCWT@91061|Bacilli,4AZIE@81852|Enterococcaceae	91061|Bacilli	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WH3_k127_9946291_4	223184.AS25_07540	5.395e-49	192.0	COG0577@1|root,COG0577@2|Bacteria,2HSU1@201174|Actinobacteria,1W7RQ@1268|Micrococcaceae	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WH3_k127_9946291_5	1155718.KB891866_gene662	1.074e-33	138.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2HB4R@201174|Actinobacteria	201174|Actinobacteria	M	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
WH3_k127_9946291_11	1223543.GP2_002_00480	3.344e-13	72.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4GEHN@85026|Gordoniaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
WH3_k127_9946291_3	1224163.B841_04950	4.35e-49	181.0	COG2518@1|root,COG2518@2|Bacteria,2HH7X@201174|Actinobacteria,22NB5@1653|Corynebacteriaceae	201174|Actinobacteria	O	Protein-L-isoaspartate carboxylmethyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
WH3_k127_9946291_8	929713.NIASO_19615	3.644e-23	100.0	COG2085@1|root,COG2085@2|Bacteria,4NPSZ@976|Bacteroidetes,1IYAV@117747|Sphingobacteriia	976|Bacteroidetes	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
## 619 queries scanned
## Total time (seconds): 3.5575778484344482
## Rate: 173.99 q/s