## Thu Feb 19 22:44:36 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/WLSH2_bin.56.fa -m mmseqs --output WLSH2_bin.56 --output_dir /data/result/bins/wyx/eggqs50+/WLSH2_bin.56 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
WLSH2_k127_10006712_0	1122603.ATVI01000007_gene1543	2.625e-50	183.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1SZ3S@1236|Gammaproteobacteria,1X7S5@135614|Xanthomonadales	135614|Xanthomonadales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WLSH2_k127_10006712_2	1121091.AUMP01000050_gene3732	5.165e-17	84.0	COG0607@1|root,COG0607@2|Bacteria,1VES3@1239|Firmicutes,4HNRE@91061|Bacilli	91061|Bacilli	P	COG0607 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
WLSH2_k127_10006712_1	272626.lin0859	5.295e-33	131.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,4HAB3@91061|Bacilli,26IV2@186820|Listeriaceae	91061|Bacilli	F	DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA- dependent ATPase activity	cshA	GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008026,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009295,GO:0009409,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
WLSH2_k127_10060930_1	797209.ZOD2009_05987	5.155e-07	55.0	COG3291@1|root,arCOG02540@1|root,arCOG04500@1|root,arCOG10954@1|root,arCOG02508@2157|Archaea,arCOG02540@2157|Archaea,arCOG04500@2157|Archaea,arCOG10954@2157|Archaea,2XWGB@28890|Euryarchaeota,23UX2@183963|Halobacteria	183963|Halobacteria	M	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_10060930_0	264462.Bd2875	3.237e-08	58.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_10145347_1	1121396.KB893074_gene3000	3.679e-38	145.0	COG0423@1|root,COG0423@2|Bacteria,1R3VX@1224|Proteobacteria,42MHG@68525|delta/epsilon subdivisions,2WKJC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
WLSH2_k127_10145347_0	642492.Clole_2359	2.246e-120	394.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
WLSH2_k127_10154160_1	582515.KR51_00026430	2.357e-05	53.0	COG0342@1|root,COG0342@2|Bacteria,1G053@1117|Cyanobacteria	1117|Cyanobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
WLSH2_k127_10154160_0	747365.Thena_0155	3.996e-56	212.0	COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,42F9I@68295|Thermoanaerobacterales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
WLSH2_k127_10173853_0	1457393.AZ09_11850	6.718e-57	205.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,2JPEV@204441|Rhodospirillales	204441|Rhodospirillales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
WLSH2_k127_10173853_1	909943.HIMB100_00006050	7.342e-10	67.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,4BPDJ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
WLSH2_k127_10197665_2	1154757.Q5C_09600	8.14e-19	91.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4H9WA@91061|Bacilli,4AX7M@81850|Leuconostocaceae	91061|Bacilli	D	DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
WLSH2_k127_10197665_0	931626.Awo_c19530	4.444e-98	326.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,25UYI@186806|Eubacteriaceae	186801|Clostridia	D	FtsK SpoIIIE family protein	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
WLSH2_k127_10197665_3	1403819.BATR01000175_gene5935	2.367e-13	70.0	COG1674@1|root,COG1674@2|Bacteria,46SCV@74201|Verrucomicrobia,2ITHR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
WLSH2_k127_10197665_1	2325.TKV_c16700	1.224e-77	278.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,42FUU@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
WLSH2_k127_10241258_0	335541.Swol_2418	1.344e-131	429.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42JIH@68298|Syntrophomonadaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
WLSH2_k127_10284355_1	1121933.AUHH01000013_gene645	1.388e-13	71.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4DN5B@85009|Propionibacteriales	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
WLSH2_k127_10284355_0	1353529.M899_2677	8.525e-17	93.0	COG0729@1|root,COG0729@2|Bacteria,1QY1J@1224|Proteobacteria,430S6@68525|delta/epsilon subdivisions,2MU2E@213481|Bdellovibrionales,2WVNT@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
WLSH2_k127_10386052_0	1111454.HMPREF1250_1264	5.747e-66	232.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,4H228@909932|Negativicutes	909932|Negativicutes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
WLSH2_k127_10390618_1	1002339.HMPREF9373_1380	1.935e-11	68.0	2CFWE@1|root,3430F@2|Bacteria,1NY3W@1224|Proteobacteria,1SQNA@1236|Gammaproteobacteria,3NM6K@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_10390618_0	509635.N824_29570	2.531e-50	181.0	COG1733@1|root,COG1733@2|Bacteria,4NSVE@976|Bacteroidetes,1IYH6@117747|Sphingobacteriia	976|Bacteroidetes	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
WLSH2_k127_10435617_0	351627.Csac_2154	4.691e-42	158.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,42ET2@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
WLSH2_k127_10476181_0	864702.OsccyDRAFT_1080	2.815e-05	49.0	COG0457@1|root,COG0457@2|Bacteria,1G0BJ@1117|Cyanobacteria,1H956@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
WLSH2_k127_10496462_0	1274374.CBLK010000070_gene1125	1.903e-44	175.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
WLSH2_k127_10496462_1	1336241.JAEB01000003_gene488	3.812e-06	51.0	COG0722@1|root,COG0722@2|Bacteria,1TQI4@1239|Firmicutes,24842@186801|Clostridia,25V2I@186806|Eubacteriaceae	186801|Clostridia	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroH	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS07240	DAHP_synth_1
WLSH2_k127_1060729_1	1444310.JANV01000096_gene3232	8.849e-11	63.0	COG0270@1|root,COG0270@2|Bacteria,1V3W2@1239|Firmicutes	1239|Firmicutes	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	2.1.1.37	ko:K17398	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko03032,ko03036	-	-	-	DNA_methylase
WLSH2_k127_1060729_0	1202532.FF52_10278	1.209e-13	74.0	COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,1HZAK@117743|Flavobacteriia,2NUID@237|Flavobacterium	976|Bacteroidetes	H	Cytosine-specific methyltransferase	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
WLSH2_k127_1060729_2	123214.PERMA_1785	4.861e-05	51.0	29WNC@1|root,30I97@2|Bacteria,2G5GG@200783|Aquificae	200783|Aquificae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_10655672_0	1096546.WYO_3662	8.603e-15	80.0	COG0137@1|root,COG0137@2|Bacteria,1MYHX@1224|Proteobacteria,2UJMK@28211|Alphaproteobacteria,1JW7B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Protein of unknown function (DUF2493)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2493
WLSH2_k127_10699946_0	592015.HMPREF1705_00894	7.41e-12	74.0	COG3464@1|root,COG3464@2|Bacteria,3TCGB@508458|Synergistetes	2|Bacteria	L	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
WLSH2_k127_10699946_1	449447.MAE_60350	4.465e-05	50.0	COG3464@1|root,COG3464@2|Bacteria,1G0IQ@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
WLSH2_k127_10757798_0	945713.IALB_1435	3.259e-26	111.0	COG0441@1|root,COG0441@2|Bacteria	2|Bacteria	J	threonyl-tRNA aminoacylation	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
WLSH2_k127_10757798_1	391587.KAOT1_08343	1.781e-05	51.0	COG1611@1|root,COG1611@2|Bacteria,4NGWU@976|Bacteroidetes,1I1G2@117743|Flavobacteriia	976|Bacteroidetes	S	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
WLSH2_k127_10757798_2	1170562.Cal6303_0676	0.0001847	45.0	COG2173@1|root,COG2173@2|Bacteria,1G07K@1117|Cyanobacteria,1HKAJ@1161|Nostocales	1117|Cyanobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
WLSH2_k127_10762886_0	1347368.HG964407_gene6726	1.348e-09	65.0	COG0628@1|root,COG0628@2|Bacteria,1TSBK@1239|Firmicutes,4HBYJ@91061|Bacilli,1ZBJD@1386|Bacillus	91061|Bacilli	S	AI-2E family transporter	ydbI	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
WLSH2_k127_10860391_3	1121447.JONL01000001_gene735	0.0007427	42.0	2EG8N@1|root,33A0G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_10860391_0	760142.Hipma_0902	1.257e-18	90.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2M6A3@213113|Desulfurellales	28221|Deltaproteobacteria	H	HemN C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
WLSH2_k127_10860391_2	204669.Acid345_2366	2.364e-08	56.0	COG0635@1|root,COG0635@2|Bacteria,3Y2ZB@57723|Acidobacteria,2JHUT@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
WLSH2_k127_10860391_1	1168034.FH5T_07875	4.44e-16	82.0	COG0635@1|root,COG0635@2|Bacteria,4NFEE@976|Bacteroidetes,2FPFC@200643|Bacteroidia	976|Bacteroidetes	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
WLSH2_k127_1093300_0	1196029.ALIM01000039_gene1162	1.263e-60	223.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,4HAGY@91061|Bacilli,1ZC3T@1386|Bacillus	91061|Bacilli	K	COG2183 Transcriptional accessory protein	tex	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
WLSH2_k127_10955823_1	1449050.JNLE01000003_gene3863	2.369e-16	81.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,36E7X@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
WLSH2_k127_10955823_0	1395513.P343_08515	2.005e-36	150.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HC58@91061|Bacilli,26P9P@186821|Sporolactobacillaceae	91061|Bacilli	S	ABC transporter	yfmM	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
WLSH2_k127_10984428_0	469618.FVAG_00150	1.48e-19	91.0	COG0745@1|root,COG0745@2|Bacteria,379HE@32066|Fusobacteria	32066|Fusobacteria	K	Psort location Cytoplasmic, score 9.97	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
WLSH2_k127_10984428_1	62928.azo3158	8.932e-17	83.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,2VRNX@28216|Betaproteobacteria,2KWBG@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulatory protein, C terminal	colR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
WLSH2_k127_11000255_1	1304284.L21TH_1456	1.309e-07	60.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853,DUF87,PLDc_2
WLSH2_k127_11000255_2	582744.Msip34_1822	2.748e-05	51.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,2VS17@28216|Betaproteobacteria,2KP7V@206350|Nitrosomonadales	206350|Nitrosomonadales	M	TIGRFAM glycosyl transferase, WecB TagA CpsF family	-	-	-	ko:K13660	-	-	-	-	ko00000,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
WLSH2_k127_11000255_0	340.xcc-b100_1723	1.068e-14	78.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,1X5CK@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the glycosyltransferase 26 family	gumM	-	-	ko:K13660	-	-	-	-	ko00000,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
WLSH2_k127_11022875_0	469618.FVAG_00297	2.994e-40	162.0	COG0341@1|root,COG0341@2|Bacteria,378NT@32066|Fusobacteria	32066|Fusobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
WLSH2_k127_11022875_1	1169152.AXVD01000028_gene3182	4.691e-11	66.0	COG4997@1|root,COG4997@2|Bacteria,2INKW@201174|Actinobacteria,4G4K9@85025|Nocardiaceae	201174|Actinobacteria	S	Phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	PRA-PH
WLSH2_k127_11083558_0	196490.AUEZ01000016_gene3160	1.649e-08	63.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,3JQS3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	CHASE2	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WLSH2_k127_11083558_1	1449063.JMLS01000002_gene1135	6.032e-06	54.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1UYB2@1239|Firmicutes,4HIMD@91061|Bacilli,26TDP@186822|Paenibacillaceae	91061|Bacilli	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WLSH2_k127_11083558_2	373903.Hore_18170	7.815e-06	54.0	COG4254@1|root,COG4254@2|Bacteria,1UTZ3@1239|Firmicutes,254XU@186801|Clostridia,3WC5R@53433|Halanaerobiales	186801|Clostridia	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
WLSH2_k127_11112723_0	264732.Moth_1553	5.972e-72	249.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,42F4T@68295|Thermoanaerobacterales	186801|Clostridia	NU	PFAM Type II secretion system protein E	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
WLSH2_k127_11336348_0	1190603.AJYD01000033_gene1822	1.584e-18	89.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1XTTR@135623|Vibrionales	135623|Vibrionales	O	COG0330 Membrane protease subunits, stomatin prohibitin homologs	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
WLSH2_k127_11346977_0	1150621.SMUL_1135	8.04e-34	137.0	COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1Q49C@1224|Proteobacteria,42MW2@68525|delta/epsilon subdivisions,2YNR7@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
WLSH2_k127_11346977_1	118166.JH976537_gene3122	0.0007044	46.0	COG5001@1|root,COG5001@2|Bacteria,1G2MB@1117|Cyanobacteria,1H722@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
WLSH2_k127_11356183_0	858215.Thexy_1234	4.229e-36	148.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,42ER8@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
WLSH2_k127_11356183_1	411469.EUBHAL_01685	9.713e-15	76.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,25VHS@186806|Eubacteriaceae	186801|Clostridia	S	Flavoprotein family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
WLSH2_k127_11384422_0	425400.LS65_02640	2.365e-10	64.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2YMZZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Ribonuclease	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB
WLSH2_k127_11462864_1	383372.Rcas_1099	4.263e-16	85.0	COG0472@1|root,COG0472@2|Bacteria,2G5TJ@200795|Chloroflexi,3750R@32061|Chloroflexia	32061|Chloroflexia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4
WLSH2_k127_11462864_0	1265507.KB899636_gene1306	9.154e-33	132.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1Y3FC@135624|Aeromonadales	135624|Aeromonadales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
WLSH2_k127_11565137_0	1216967.L100_15405	2.995e-05	55.0	COG0516@1|root,COG0516@2|Bacteria,4NDXQ@976|Bacteroidetes,1HWYC@117743|Flavobacteriia,34QZ9@308865|Elizabethkingia	976|Bacteroidetes	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
WLSH2_k127_117085_1	1267580.AF6_0048	2.528e-11	64.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4HH2Z@91061|Bacilli,21VIY@150247|Anoxybacillus	91061|Bacilli	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
WLSH2_k127_117085_0	1211814.CAPG01000094_gene4315	1.175e-15	77.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4HH2Z@91061|Bacilli,1ZC7I@1386|Bacillus	91061|Bacilli	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
WLSH2_k127_1183610_0	288705.RSal33209_2728	6.405e-06	56.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria,1W7WB@1268|Micrococcaceae	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH2_k127_1191716_3	552811.Dehly_0754	2.918e-12	70.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi,34DBK@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Single-strand binding protein family	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
WLSH2_k127_1191716_2	759362.KVU_0640	5.313e-14	75.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
WLSH2_k127_1191716_1	1280696.ATVY01000009_gene3088	1.112e-22	98.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,4BXTC@830|Butyrivibrio	186801|Clostridia	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
WLSH2_k127_1191716_0	545695.TREAZ_0059	7.687e-84	281.0	COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
WLSH2_k127_1202391_3	1123057.P872_19655	2.968e-33	129.0	COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,47J9E@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
WLSH2_k127_1202391_1	1123057.P872_19655	3.108e-60	210.0	COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,47J9E@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
WLSH2_k127_1202391_2	926549.KI421517_gene787	1.211e-44	166.0	COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,47J9E@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
WLSH2_k127_1202391_0	880073.Calab_0503	4.649e-139	454.0	COG0826@1|root,COG0826@2|Bacteria,2NPQH@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	yegQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
WLSH2_k127_1234073_1	269798.CHU_2214	4.968e-08	57.0	COG0812@1|root,COG0812@2|Bacteria,4NE78@976|Bacteroidetes,47KJJ@768503|Cytophagia	976|Bacteroidetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
WLSH2_k127_1234073_0	246194.CHY_0259	2.229e-94	312.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WLSH2_k127_1308696_0	215803.DB30_7413	0.0009203	49.0	COG4254@1|root,COG4254@2|Bacteria,1QVB5@1224|Proteobacteria,42XP1@68525|delta/epsilon subdivisions,2X71D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
WLSH2_k127_131428_1	1379858.N508_01794	2.196e-22	99.0	COG0769@1|root,COG0769@2|Bacteria,2GEVK@200930|Deferribacteres	200930|Deferribacteres	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WLSH2_k127_131428_0	1380408.AVGH01000039_gene2250	3.336e-46	175.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,4H9T1@91061|Bacilli,21WCG@150247|Anoxybacillus	91061|Bacilli	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WLSH2_k127_1320622_0	1123511.KB905844_gene1246	1.414e-29	128.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,4H27E@909932|Negativicutes	909932|Negativicutes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
WLSH2_k127_133770_5	195522.BD01_0260	3.562e-06	53.0	COG4902@1|root,arCOG03957@2157|Archaea,2XX05@28890|Euryarchaeota,243Z0@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
WLSH2_k127_133770_2	381764.Fnod_1376	8.638e-12	70.0	COG4902@1|root,COG4902@2|Bacteria,2GD4X@200918|Thermotogae	200918|Thermotogae	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
WLSH2_k127_133770_4	880073.Calab_1806	3.243e-09	63.0	295PX@1|root,2ZT19@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_133770_1	589865.DaAHT2_1497	6.248e-13	72.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2MKZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
WLSH2_k127_133770_0	880073.Calab_1805	6.976e-17	83.0	COG1595@1|root,COG1595@2|Bacteria,2NRM3@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
WLSH2_k127_133770_3	1144313.PMI10_03848	4.695e-10	60.0	COG3967@1|root,COG3967@2|Bacteria,4NMPW@976|Bacteroidetes,1I7IH@117743|Flavobacteriia,2NTGD@237|Flavobacterium	976|Bacteroidetes	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
WLSH2_k127_1383502_0	398767.Glov_1103	1.556e-08	60.0	COG2888@1|root,COG2888@2|Bacteria,1MZH3@1224|Proteobacteria,42VBG@68525|delta/epsilon subdivisions,2WTZB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_1383502_1	748449.Halha_1907	8.499e-07	57.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,3WAMF@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
WLSH2_k127_1383502_2	714961.BFZC1_06913	6.391e-05	50.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4HBB4@91061|Bacilli,3IVQD@400634|Lysinibacillus	91061|Bacilli	L	DNA polymerase III subunit delta	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
WLSH2_k127_1447611_1	1047013.AQSP01000118_gene1252	3.641e-87	302.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_1447611_2	1123499.KB908019_gene2280	1.329e-10	64.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,2KPX7@206351|Neisseriales	206351|Neisseriales	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
WLSH2_k127_1447611_0	1297581.H919_08911	4.223e-93	316.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,21W0M@150247|Anoxybacillus	91061|Bacilli	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
WLSH2_k127_1454334_0	416348.Hlac_2824	2.139e-22	113.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
WLSH2_k127_1483178_0	1121028.ARQE01000004_gene1447	0.0004488	47.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U7GY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NU	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
WLSH2_k127_1483572_0	5762.XP_002679746.1	1.146e-23	106.0	COG0498@1|root,KOG2616@2759|Eukaryota	2759|Eukaryota	E	2-oxobutyrate metabolic process	THNSL1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,SKI,Thr_synth_N
WLSH2_k127_1494375_0	635013.TherJR_0647	6.344e-11	68.0	COG3503@1|root,COG3503@2|Bacteria,1V8H3@1239|Firmicutes,24JRC@186801|Clostridia,2654I@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
WLSH2_k127_1494375_2	1123277.KB893208_gene2818	9.729e-09	57.0	COG0412@1|root,COG0412@2|Bacteria,4NEUX@976|Bacteroidetes,47JGG@768503|Cytophagia	976|Bacteroidetes	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
WLSH2_k127_1494375_3	500153.JOEK01000007_gene4368	1.502e-05	48.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
WLSH2_k127_1494375_4	56780.SYN_02346	0.0003443	44.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42Q9U@68525|delta/epsilon subdivisions,2X5CC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
WLSH2_k127_1494375_1	1459636.NTE_03129	6.312e-09	57.0	COG0412@1|root,arCOG01659@2157|Archaea,41T1E@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Chlorophyllase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
WLSH2_k127_1513746_0	933262.AXAM01000006_gene1877	8.022e-09	64.0	COG4642@1|root,COG4642@2|Bacteria,1P07C@1224|Proteobacteria,42VAN@68525|delta/epsilon subdivisions,2WRN9@28221|Deltaproteobacteria,2MNSH@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases.	-	-	-	-	-	-	-	-	-	-	-	-	MORN
WLSH2_k127_1518860_0	1392498.JQLH01000001_gene90	9.717e-11	64.0	COG4339@1|root,COG4339@2|Bacteria,4PKIS@976|Bacteroidetes,1IJAC@117743|Flavobacteriia,2PHX8@252356|Maribacter	976|Bacteroidetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
WLSH2_k127_1547934_0	526218.Sterm_3675	9.717e-11	64.0	COG0796@1|root,COG0796@2|Bacteria,379AN@32066|Fusobacteria	32066|Fusobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
WLSH2_k127_1547934_1	224324.aq_2075	7.761e-10	65.0	COG0771@1|root,COG0771@2|Bacteria,2G3XE@200783|Aquificae	200783|Aquificae	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
WLSH2_k127_1558349_0	1196029.ALIM01000014_gene3668	1.702e-25	111.0	COG0628@1|root,COG0628@2|Bacteria,1TSBK@1239|Firmicutes,4HBYJ@91061|Bacilli,1ZBJD@1386|Bacillus	91061|Bacilli	S	AI-2E family transporter	ydbI	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
WLSH2_k127_1558349_1	694440.JOMF01000009_gene672	5.958e-14	74.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,2N962@224756|Methanomicrobia	224756|Methanomicrobia	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
WLSH2_k127_1559254_0	748449.Halha_1207	2.675e-97	328.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WA9E@53433|Halanaerobiales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
WLSH2_k127_1559254_1	388467.A19Y_0237	1.083e-19	101.0	COG1235@1|root,COG1235@2|Bacteria,1G166@1117|Cyanobacteria,1H884@1150|Oscillatoriales	1117|Cyanobacteria	S	of the beta-lactamase superfamily I	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
WLSH2_k127_1619354_0	1444309.JAQG01000106_gene1117	7.497e-147	481.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,4H9X0@91061|Bacilli,26U46@186822|Paenibacillaceae	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
WLSH2_k127_1684533_0	1123405.AUMM01000022_gene1885	8.222e-20	98.0	COG0726@1|root,COG0726@2|Bacteria,1UVMR@1239|Firmicutes,4I3K7@91061|Bacilli,26PX3@186821|Sporolactobacillaceae	91061|Bacilli	G	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
WLSH2_k127_1687285_2	589924.Ferp_0187	5.195e-11	67.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,245RN@183980|Archaeoglobi	183980|Archaeoglobi	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
WLSH2_k127_1687285_0	1321779.HMPREF1984_00956	4.042e-33	130.0	COG0719@1|root,COG0719@2|Bacteria,378VG@32066|Fusobacteria	32066|Fusobacteria	O	feS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
WLSH2_k127_1687285_1	797303.Natpe_2774	1.192e-14	74.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,23S0E@183963|Halobacteria	183963|Halobacteria	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB1	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
WLSH2_k127_1687857_1	1123313.ATUT01000001_gene979	9.481e-36	137.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,3VPIX@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
WLSH2_k127_1687857_2	1235835.C814_03224	3.673e-09	57.0	COG0514@1|root,COG0551@1|root,COG0514@2|Bacteria,COG0551@2|Bacteria,1V63N@1239|Firmicutes,24A9F@186801|Clostridia,3WJKK@541000|Ruminococcaceae	186801|Clostridia	L	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	HRDC,NERD
WLSH2_k127_1687857_0	649747.HMPREF0083_05957	7.768e-98	323.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H9Y6@91061|Bacilli,26R74@186822|Paenibacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
WLSH2_k127_1735128_2	1158165.KB898878_gene2631	0.0006651	43.0	COG3608@1|root,COG3608@2|Bacteria,1MV55@1224|Proteobacteria,1S6VH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
WLSH2_k127_1735128_1	1278309.KB907100_gene2163	2.217e-09	63.0	COG3608@1|root,COG3608@2|Bacteria,1MV55@1224|Proteobacteria,1S6VH@1236|Gammaproteobacteria,1XPHG@135619|Oceanospirillales	135619|Oceanospirillales	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
WLSH2_k127_1735128_0	765420.OSCT_0924	2.136e-31	134.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	Prok-JAB,ThiF
WLSH2_k127_1738676_0	748449.Halha_0216	1.886e-55	205.0	COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,3WAFV@53433|Halanaerobiales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
WLSH2_k127_1738676_3	608506.COB47_0868	1.724e-16	83.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,42GJW@68295|Thermoanaerobacterales	186801|Clostridia	J	ribosomal protein l17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
WLSH2_k127_1738676_1	1286171.EAL2_c01920	3.196e-40	153.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,25WEH@186806|Eubacteriaceae	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
WLSH2_k127_1738676_2	717231.Flexsi_1959	1.688e-29	121.0	COG0103@1|root,COG0103@2|Bacteria,2GFQZ@200930|Deferribacteres	200930|Deferribacteres	J	Ribosomal protein S9/S16	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
WLSH2_k127_1870750_1	1480694.DC28_08980	3.74e-06	53.0	COG0592@1|root,COG0592@2|Bacteria,2J629@203691|Spirochaetes	203691|Spirochaetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
WLSH2_k127_1870750_0	1128421.JAGA01000002_gene422	4.159e-23	104.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
WLSH2_k127_1898496_0	402612.FP0151	3.697e-16	80.0	COG3963@1|root,COG3963@2|Bacteria,4NPMV@976|Bacteroidetes,1I1YR@117743|Flavobacteriia	976|Bacteroidetes	I	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	MTS,Methyltransf_12,Methyltransf_25,RrnaAD
WLSH2_k127_1968226_3	684949.ATTJ01000001_gene2940	0.0003638	46.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	GO:0003674,GO:0003824,GO:0016787	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Acetyltransf_3,NUDIX
WLSH2_k127_1968226_2	1121380.JNIW01000026_gene291	5.7e-07	53.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	GO:0003674,GO:0003824,GO:0016787	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Acetyltransf_3,NUDIX
WLSH2_k127_1968226_0	484770.UFO1_3993	8.338e-36	143.0	COG0406@1|root,COG0406@2|Bacteria,1V8H5@1239|Firmicutes,4H4V2@909932|Negativicutes	909932|Negativicutes	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WLSH2_k127_1986133_0	1395513.P343_03390	4.889e-12	73.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli,26NM5@186821|Sporolactobacillaceae	91061|Bacilli	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WLSH2_k127_2047425_0	497965.Cyan7822_4390	1.016e-05	52.0	COG1950@1|root,COG1950@2|Bacteria,1G7RB@1117|Cyanobacteria,3KIDQ@43988|Cyanothece	1117|Cyanobacteria	S	PFAM membrane protein of	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
WLSH2_k127_2209657_1	1121087.AUCK01000008_gene2243	3.952e-35	138.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,1ZD5J@1386|Bacillus	91061|Bacilli	NU	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilB	-	-	ko:K02243,ko:K02652	-	M00429	-	-	ko00000,ko00002,ko02035,ko02044	3.A.14.1,3.A.15.2	-	-	T2SSE,T2SSE_N
WLSH2_k127_2209657_0	555088.DealDRAFT_0765	5.572e-54	196.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,42KEX@68298|Syntrophomonadaceae	186801|Clostridia	NU	General secretory system II protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
WLSH2_k127_2222790_3	653733.Selin_1826	3.428e-05	49.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
WLSH2_k127_2222790_2	1045858.Bint_2257	1.105e-07	55.0	COG1195@1|root,COG1195@2|Bacteria,2J5MP@203691|Spirochaetes	203691|Spirochaetes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
WLSH2_k127_2222790_0	525254.HMPREF0072_1163	4.546e-26	117.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,22GV9@1570339|Peptoniphilaceae	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
WLSH2_k127_2222790_4	1121930.AQXG01000002_gene2352	4.291e-05	56.0	COG2373@1|root,COG2755@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4412@1|root,COG4932@1|root,COG2373@2|Bacteria,COG2755@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	pelX	-	-	ko:K07004,ko:K09955,ko:K16915,ko:K20276	ko02010,ko02024,map02010,map02024	M00246	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	Beta_helix,Laminin_G_3
WLSH2_k127_2222790_1	1157490.EL26_15815	3.718e-24	104.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,277XE@186823|Alicyclobacillaceae	91061|Bacilli	D	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WLSH2_k127_2233260_0	269799.Gmet_0292	5.475e-05	54.0	COG4412@1|root,COG4932@1|root,COG4412@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,42RZP@68525|delta/epsilon subdivisions,2X7KQ@28221|Deltaproteobacteria,43SHG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_2379847_0	111780.Sta7437_0383	3.576e-29	126.0	COG1559@1|root,COG1559@2|Bacteria,1G27J@1117|Cyanobacteria,3VJCI@52604|Pleurocapsales	1117|Cyanobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
WLSH2_k127_2379847_1	373903.Hore_00650	1.597e-22	102.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3WA5Y@53433|Halanaerobiales	186801|Clostridia	M	PDZ domain (Also known as DHR or GLGF)	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WLSH2_k127_2379847_2	446470.Snas_5142	2.234e-07	52.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4EY90@85014|Glycomycetales	201174|Actinobacteria	O	PDZ domain (Also known as DHR or GLGF)	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
WLSH2_k127_2379847_3	691883.XP_009493491.1	0.0008007	44.0	COG0265@1|root,KOG1320@2759|Eukaryota,38G0B@33154|Opisthokonta	33154|Opisthokonta	O	pentacyclic triterpenoid metabolic process	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
WLSH2_k127_2403624_0	1266925.JHVX01000006_gene2075	4.835e-05	51.0	COG4733@1|root,COG4733@2|Bacteria,1PMY6@1224|Proteobacteria,2VNMV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage-tail_3
WLSH2_k127_2428257_1	5722.XP_001582441.1	5.626e-14	76.0	COG1643@1|root,KOG0925@2759|Eukaryota	2759|Eukaryota	L	helicase activity	-	-	3.6.4.13	ko:K12820,ko:K20101	ko03040,map03040	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03041	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
WLSH2_k127_2428257_0	767434.Fraau_0825	8.014e-35	144.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1X3EJ@135614|Xanthomonadales	135614|Xanthomonadales	L	Helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
WLSH2_k127_2458440_2	679926.Mpet_1589	5.502e-14	82.0	COG3209@1|root,arCOG12091@2157|Archaea,2Y87Z@28890|Euryarchaeota,2NBP1@224756|Methanomicrobia	224756|Methanomicrobia	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_2458440_3	862751.SACTE_5519	7.097e-06	54.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
WLSH2_k127_2458440_0	1318628.MARLIPOL_09971	4.447e-48	189.0	COG1372@1|root,COG1520@1|root,COG3209@1|root,COG1372@2|Bacteria,COG1520@2|Bacteria,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,46DDZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	LM	Rhs Family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF5122,He_PIG,PT-HINT,RHS_repeat
WLSH2_k127_2458440_1	760192.Halhy_1128	6.046e-48	188.0	COG3209@1|root,COG3209@2|Bacteria,4NFUE@976|Bacteroidetes,1INSI@117747|Sphingobacteriia	976|Bacteroidetes	M	COG3209 Rhs family protein	rhsA	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
WLSH2_k127_2542330_0	471852.Tcur_2628	8.52e-97	323.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GNDC@201174|Actinobacteria,4EG2R@85012|Streptosporangiales	201174|Actinobacteria	F	IMP dehydrogenase / GMP reductase domain	guaB1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
WLSH2_k127_2542330_1	404589.Anae109_3133	9.747e-44	165.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,2YXKD@29|Myxococcales	28221|Deltaproteobacteria	C	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
WLSH2_k127_2542330_2	1499967.BAYZ01000076_gene830	6.448e-34	138.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
WLSH2_k127_2543466_0	387631.Asulf_00287	3.222e-53	190.0	COG1683@1|root,arCOG04848@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
WLSH2_k127_2573110_4	344747.PM8797T_12218	4.457e-08	54.0	COG0185@1|root,COG0185@2|Bacteria,2J0BB@203682|Planctomycetes	203682|Planctomycetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
WLSH2_k127_2573110_5	1128421.JAGA01000002_gene700	6.964e-08	54.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WLSH2_k127_2573110_0	771875.Ferpe_1413	2.998e-77	265.0	COG0090@1|root,COG0090@2|Bacteria,2GBXA@200918|Thermotogae	200918|Thermotogae	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WLSH2_k127_2573110_3	525909.Afer_0400	6.809e-12	69.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4CN84@84992|Acidimicrobiia	84992|Acidimicrobiia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
WLSH2_k127_2573110_1	742733.HMPREF9469_05246	2.014e-37	148.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,21XPR@1506553|Lachnoclostridium	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
WLSH2_k127_2573110_2	1276229.SSYRP_v1c02150	4.528e-33	134.0	COG0087@1|root,COG0087@2|Bacteria,3WT04@544448|Tenericutes	544448|Tenericutes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
WLSH2_k127_2577189_2	457396.CSBG_01165	1.053e-15	79.0	COG0144@1|root,COG0144@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,36F0B@31979|Clostridiaceae	186801|Clostridia	J	NOL1 NOP2 sun family	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
WLSH2_k127_2577189_0	1487921.DP68_10350	5.317e-44	168.0	COG0144@1|root,COG0144@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,36F0B@31979|Clostridiaceae	186801|Clostridia	J	NOL1 NOP2 sun family	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
WLSH2_k127_2577189_1	1382230.ASAP_2763	1.971e-16	82.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_2616327_0	1353529.M899_1215	9.559e-117	386.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2MSMW@213481|Bdellovibrionales,2WJ3E@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
WLSH2_k127_2616327_1	264462.Bd3872	7.515e-27	110.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2MTIB@213481|Bdellovibrionales,2WJV2@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	Heat shock protein DnaJ domain protein	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
WLSH2_k127_2616327_2	224719.Abm4_1618	0.0001414	46.0	arCOG06880@1|root,arCOG06880@2157|Archaea,2Y864@28890|Euryarchaeota	28890|Euryarchaeota	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
WLSH2_k127_2628853_0	290512.Paes_0433	2.015e-06	55.0	COG1185@1|root,COG1432@1|root,COG1185@2|Bacteria,COG1432@2|Bacteria,1FEI0@1090|Chlorobi	1090|Chlorobi	J	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
WLSH2_k127_2674916_3	632245.CLP_3684	2.639e-05	50.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,36EHE@31979|Clostridiaceae	186801|Clostridia	O	Glycoprotease	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
WLSH2_k127_2674916_5	485913.Krac_12036	0.0007889	49.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	PASTA,bPH_2
WLSH2_k127_2674916_2	748449.Halha_2196	1.792e-25	109.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WBCB@53433|Halanaerobiales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Thioredoxin
WLSH2_k127_2674916_1	1408312.JNJS01000009_gene940	6.124e-41	157.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3NHJM@46205|Pseudobutyrivibrio	186801|Clostridia	O	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WLSH2_k127_2674916_0	1408416.JNJT01000013_gene431	1.61e-88	298.0	COG0207@1|root,COG0207@2|Bacteria,3WT2X@544448|Tenericutes	544448|Tenericutes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
WLSH2_k127_2674916_4	252305.OB2597_15480	7.093e-05	47.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,2PE8S@252301|Oceanicola	28211|Alphaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
WLSH2_k127_2677428_2	938293.CAJU020000003_gene951	8.199e-25	108.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,22G4C@1570339|Peptoniphilaceae	186801|Clostridia	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
WLSH2_k127_2677428_3	1123060.JONP01000001_gene1503	2.889e-20	93.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria,2JPRG@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
WLSH2_k127_2677428_0	333138.LQ50_13520	9.414e-93	314.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,4H9YV@91061|Bacilli,1ZBY9@1386|Bacillus	91061|Bacilli	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
WLSH2_k127_2677428_1	1033740.CAEW01000030_gene59	1.377e-65	227.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,4HA8J@91061|Bacilli,26DM2@186818|Planococcaceae	91061|Bacilli	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0006355,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051603,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
WLSH2_k127_2688594_1	1192034.CAP_2187	5.807e-16	81.0	COG0641@1|root,COG0641@2|Bacteria,1NG2E@1224|Proteobacteria,43BH9@68525|delta/epsilon subdivisions,2X6VN@28221|Deltaproteobacteria,2YYEN@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
WLSH2_k127_2688594_0	391625.PPSIR1_25641	4.511e-43	162.0	COG0641@1|root,COG0641@2|Bacteria,1NG2E@1224|Proteobacteria,43BH9@68525|delta/epsilon subdivisions,2X6VN@28221|Deltaproteobacteria,2YYEN@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
WLSH2_k127_2688594_2	515622.bpr_I1900	2.413e-15	80.0	COG0641@1|root,COG0641@2|Bacteria,1UZY1@1239|Firmicutes,24B2I@186801|Clostridia,4C0XV@830|Butyrivibrio	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
WLSH2_k127_2697294_0	935837.JAEK01000054_gene1465	0.0008796	48.0	COG4373@1|root,COG4373@2|Bacteria,1TQNK@1239|Firmicutes,4HDES@91061|Bacilli,1ZBVH@1386|Bacillus	91061|Bacilli	S	Mu-like prophage FluMu protein gp28	gp17a	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
WLSH2_k127_2715705_0	338966.Ppro_2445	3.883e-05	53.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,CHU_C,Copper-bind,DUF1080,DUF11
WLSH2_k127_2749881_0	1232436.CAPF01000097_gene46	7.53e-07	58.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CUJI@84998|Coriobacteriia	84998|Coriobacteriia	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
WLSH2_k127_2749881_1	330214.NIDE3436	4.934e-05	54.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE3436|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_2757318_0	1392501.JIAC01000001_gene453	2.113e-22	98.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H206@909932|Negativicutes	909932|Negativicutes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
WLSH2_k127_2804444_0	479433.Caci_0451	1.441e-06	60.0	COG1470@1|root,COG1470@2|Bacteria,2I2TR@201174|Actinobacteria	201174|Actinobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF916
WLSH2_k127_2811973_2	176275.XP_008598074.1	0.0005298	45.0	COG1418@1|root,2S0QA@2759|Eukaryota,39J54@33154|Opisthokonta,3Q3HC@4751|Fungi,3RKIQ@4890|Ascomycota,217KY@147550|Sordariomycetes,3TD02@5125|Hypocreales	4751|Fungi	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
WLSH2_k127_2811973_1	96561.Dole_1644	4.637e-38	145.0	COG1418@1|root,COG1418@2|Bacteria,1RB2W@1224|Proteobacteria,42RBY@68525|delta/epsilon subdivisions,2WN17@28221|Deltaproteobacteria,2MJPD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
WLSH2_k127_2811973_0	335543.Sfum_3302	9.595e-92	310.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MR5T@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
WLSH2_k127_2812282_0	717231.Flexsi_1182	3.102e-07	57.0	COG2203@1|root,COG2204@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	DUF3369,GAF,GAF_2,HD,HD_5,Response_reg
WLSH2_k127_2815689_0	865937.Gilli_2498	5.427e-27	118.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,HHH_3
WLSH2_k127_284741_0	1273103.NM10_04383	2.116e-42	162.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,4H2YZ@909932|Negativicutes	909932|Negativicutes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
WLSH2_k127_28594_1	1122176.KB903549_gene1245	1.79e-05	53.0	COG4102@1|root,COG4102@2|Bacteria,4NFFC@976|Bacteroidetes,1IWTR@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
WLSH2_k127_28594_0	639030.JHVA01000001_gene213	9.765e-09	68.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria,2JI17@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
WLSH2_k127_2875934_1	192952.MM_1911	1.707e-18	87.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,2N95H@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
WLSH2_k127_2875934_0	436114.SYO3AOP1_0685	3.505e-26	114.0	COG0217@1|root,COG0217@2|Bacteria,2G3N5@200783|Aquificae	200783|Aquificae	K	transcriptional regulatory protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
WLSH2_k127_2883965_1	768706.Desor_4089	2.745e-14	76.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,2641K@186807|Peptococcaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	nolG2	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
WLSH2_k127_2883965_0	1288963.ADIS_3499	2.256e-27	127.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47MTC@768503|Cytophagia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
WLSH2_k127_2883965_4	1117318.PRUB_05736	6.551e-05	49.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q1FC@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18989	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30	-	-	ACR_tran
WLSH2_k127_2883965_3	1515615.HQ41_05945	1.79e-08	59.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,2FM3B@200643|Bacteroidia,22VY6@171551|Porphyromonadaceae	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
WLSH2_k127_2883965_2	223926.28807470	2.113e-12	72.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XU61@135623|Vibrionales	135623|Vibrionales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18989	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30	-	-	ACR_tran
WLSH2_k127_2929404_0	1289135.A966_04281	8.637e-14	76.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
WLSH2_k127_2929404_1	1304875.JAFZ01000001_gene1554	4.144e-08	59.0	COG1335@1|root,COG1335@2|Bacteria,3TAXX@508458|Synergistetes	508458|Synergistetes	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
WLSH2_k127_2933354_1	998088.B565_1840	0.0003189	45.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1S9P2@1236|Gammaproteobacteria,1Y5ZG@135624|Aeromonadales	135624|Aeromonadales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
WLSH2_k127_2933354_2	1128398.Curi_c03470	0.0008264	43.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,2694A@186813|unclassified Clostridiales	186801|Clostridia	M	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
WLSH2_k127_2933354_0	72019.SARC_07190T0	4.781e-05	50.0	KOG1216@1|root,KOG1216@2759|Eukaryota	2759|Eukaryota	S	sensory perception of sound	-	-	-	-	-	-	-	-	-	-	-	-	Antistasin,EB
WLSH2_k127_2933461_1	1288963.ADIS_4786	2.262e-28	117.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,47KYI@768503|Cytophagia	976|Bacteroidetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WLSH2_k127_2933461_0	552811.Dehly_0095	6.683e-39	149.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi,34CQM@301297|Dehalococcoidia	301297|Dehalococcoidia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WLSH2_k127_2933461_2	227941.CCA_00128	0.0002962	43.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2JFW6@204428|Chlamydiae	204428|Chlamydiae	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WLSH2_k127_2934305_0	1304284.L21TH_0428	5.09e-06	53.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,36KNM@31979|Clostridiaceae	186801|Clostridia	T	Belongs to the anti-sigma-factor antagonist family	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
WLSH2_k127_308156_2	5888.CAK71390	8.253e-38	147.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
WLSH2_k127_308156_1	869209.Tresu_1137	5.005e-91	306.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
WLSH2_k127_308156_0	1539298.JO41_01275	5.598e-193	638.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
WLSH2_k127_308156_3	1120973.AQXL01000096_gene3018	0.0005324	49.0	COG4926@1|root,COG4926@2|Bacteria,1U67P@1239|Firmicutes,4HAN5@91061|Bacilli	91061|Bacilli	L	Phage minor structural protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,Prophage_tail
WLSH2_k127_3100295_0	1395513.P343_08515	1.062e-32	137.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HC58@91061|Bacilli,26P9P@186821|Sporolactobacillaceae	91061|Bacilli	S	ABC transporter	yfmM	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
WLSH2_k127_3100295_1	1463856.JOHY01000007_gene621	3.484e-20	95.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria	201174|Actinobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
WLSH2_k127_3216659_0	1162668.LFE_1113	1.132e-25	118.0	COG3391@1|root,COG3391@2|Bacteria,3J19W@40117|Nitrospirae	40117|Nitrospirae	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
WLSH2_k127_329364_1	555079.Toce_1232	5.277e-28	117.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,42GTG@68295|Thermoanaerobacterales	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
WLSH2_k127_329364_0	289397.MBOVPG45_0594	9.47e-45	173.0	COG0130@1|root,COG0130@2|Bacteria,3WTAQ@544448|Tenericutes	544448|Tenericutes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
WLSH2_k127_329364_3	1128421.JAGA01000002_gene636	4.797e-13	76.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	XK27_09705	-	6.1.1.14	ko:K01879,ko:K06950	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HD
WLSH2_k127_329364_2	491916.RHECIAT_CH0001457	1.322e-15	85.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,4B6YV@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
WLSH2_k127_332772_2	562981.HMPREF0428_00066	6.239e-11	63.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,4HAH8@91061|Bacilli,3WDZV@539002|Bacillales incertae sedis	91061|Bacilli	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
WLSH2_k127_332772_1	179408.Osc7112_1554	3.049e-13	72.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
WLSH2_k127_332772_0	313612.L8106_04089	4.932e-21	102.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
WLSH2_k127_332772_3	1463841.JOIR01000004_gene6340	0.0005003	45.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria	201174|Actinobacteria	NU	membrane	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
WLSH2_k127_3350148_3	1297617.JPJD01000032_gene2048	2.924e-07	53.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,26941@186813|unclassified Clostridiales	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
WLSH2_k127_3350148_2	1122951.ATUE01000009_gene426	1.578e-24	105.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,3NNY1@468|Moraxellaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
WLSH2_k127_3350148_1	273068.TTE2297	2.391e-35	139.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,42G2K@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
WLSH2_k127_3350148_0	1006581.GCW_03035	1.291e-54	194.0	COG0048@1|root,COG0048@2|Bacteria,3WTGE@544448|Tenericutes	544448|Tenericutes	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WLSH2_k127_3411220_0	701521.PECL_1342	5.742e-06	55.0	COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,4H9QP@91061|Bacilli,3F4PY@33958|Lactobacillaceae	91061|Bacilli	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
WLSH2_k127_3429395_0	743836.AYNA01000126_gene1337	5.244e-95	317.0	COG2159@1|root,COG2159@2|Bacteria,1R8EW@1224|Proteobacteria,2UVN1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
WLSH2_k127_3438261_1	1183438.GKIL_2905	3.284e-05	48.0	COG4252@1|root,COG5002@1|root,COG4252@2|Bacteria,COG5002@2|Bacteria,1GHEK@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,dCache_1
WLSH2_k127_3438261_0	867845.KI911784_gene3464	6.558e-06	49.0	COG0175@1|root,COG0175@2|Bacteria	2|Bacteria	EH	sulfate reduction	-	-	-	-	-	-	-	-	-	-	-	-	PAPS_reduct
WLSH2_k127_3494714_0	96561.Dole_0034	1.544e-32	136.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MHQU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WLSH2_k127_3494714_1	1380394.JADL01000001_gene2959	3.115e-11	64.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VFBT@28211|Alphaproteobacteria,2JRT5@204441|Rhodospirillales	204441|Rhodospirillales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WLSH2_k127_3515608_0	593750.Metfor_1904	2.219e-05	50.0	COG1196@1|root,arCOG00371@2157|Archaea	2157|Archaea	D	Required for chromosome condensation and partitioning	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12
WLSH2_k127_353701_0	742723.HMPREF9477_01578	2.029e-39	154.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,27IR1@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
WLSH2_k127_3553876_0	1122603.ATVI01000009_gene2511	1.177e-07	61.0	COG2374@1|root,COG3325@1|root,COG3386@1|root,COG2374@2|Bacteria,COG3325@2|Bacteria,COG3386@2|Bacteria,1MX52@1224|Proteobacteria,1RRGN@1236|Gammaproteobacteria,1X3H2@135614|Xanthomonadales	135614|Xanthomonadales	Q	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,LTD
WLSH2_k127_3553876_1	933115.GPDM_16316	8.032e-07	55.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HEC8@91061|Bacilli,26I8Q@186818|Planococcaceae	91061|Bacilli	M	Cell wall-associated	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SLH
WLSH2_k127_3582636_6	207559.Dde_2039	0.0001844	51.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2M8WH@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
WLSH2_k127_3582636_3	1122915.AUGY01000062_gene4437	7.505e-31	125.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,4HKKX@91061|Bacilli,26YJD@186822|Paenibacillaceae	91061|Bacilli	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH2_k127_3582636_1	1163745.HCD_01375	2.218e-63	226.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2YM9U@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
WLSH2_k127_3582636_4	1244528.CFT03427_1152	6.473e-13	69.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2YM9U@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
WLSH2_k127_3582636_0	59374.Fisuc_2482	3.926e-106	350.0	COG0112@1|root,COG0112@2|Bacteria	2|Bacteria	E	glycine hydroxymethyltransferase activity	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081	SHMT
WLSH2_k127_3582636_2	469616.FMAG_00288	2.039e-51	186.0	COG0112@1|root,COG0112@2|Bacteria,3793W@32066|Fusobacteria	32066|Fusobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
WLSH2_k127_3582636_5	858215.Thexy_1526	1.253e-12	78.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,42F11@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
WLSH2_k127_3582636_7	1122143.AUEG01000001_gene209	0.0003476	48.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9M4@91061|Bacilli,27FE1@186828|Carnobacteriaceae	91061|Bacilli	S	Competence protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
WLSH2_k127_3589628_0	990073.ATHU01000001_gene1413	5.89e-62	231.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2YMNY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
WLSH2_k127_3621021_0	1123058.KB894217_gene507	2.053e-44	168.0	COG0233@1|root,COG0233@2|Bacteria,4NF95@976|Bacteroidetes,1HYRH@117743|Flavobacteriia	976|Bacteroidetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
WLSH2_k127_3644574_0	240292.Ava_2941	1.175e-20	101.0	COG4339@1|root,COG4339@2|Bacteria,1G5Q9@1117|Cyanobacteria,1HJAE@1161|Nostocales	1117|Cyanobacteria	S	COGs COG4339 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_3688121_3	386456.JQKN01000005_gene507	0.000359	49.0	COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota	28890|Euryarchaeota	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
WLSH2_k127_3688121_0	944480.ATUV01000001_gene1352	1.414e-13	73.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2M6KW@213113|Desulfurellales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
WLSH2_k127_3688121_2	1319815.HMPREF0202_01881	8.966e-10	61.0	COG0768@1|root,COG0768@2|Bacteria,37861@32066|Fusobacteria	32066|Fusobacteria	M	Penicillin-binding protein, transpeptidase domain protein	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
WLSH2_k127_3688121_1	56780.SYN_01739	4.243e-12	68.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2MQXI@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
WLSH2_k127_369371_0	1408433.JHXV01000016_gene1847	2.436e-09	67.0	COG1708@1|root,COG1708@2|Bacteria,4NPRU@976|Bacteroidetes,1I105@117743|Flavobacteriia	976|Bacteroidetes	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
WLSH2_k127_3770868_0	1262914.BN533_00681	4.467e-78	268.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,4H36V@909932|Negativicutes	909932|Negativicutes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
WLSH2_k127_3813351_0	411465.PEPMIC_01496	1.075e-129	437.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,22G9P@1570339|Peptoniphilaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
WLSH2_k127_3820307_0	332101.JIBU02000005_gene319	5.1e-07	59.0	2BGQZ@1|root,32AQ0@2|Bacteria,1UGJA@1239|Firmicutes,25P1N@186801|Clostridia,36TFV@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_3855594_0	1340493.JNIF01000003_gene1736	5.39e-77	264.0	COG0016@1|root,COG0016@2|Bacteria,3Y3NJ@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
WLSH2_k127_3866281_0	324602.Caur_2075	1.064e-22	104.0	COG0576@1|root,COG0576@2|Bacteria,2G77I@200795|Chloroflexi,375MV@32061|Chloroflexia	32061|Chloroflexia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
WLSH2_k127_3889318_0	319225.Plut_0261	6.297e-35	138.0	COG0629@1|root,COG0629@2|Bacteria,1FE0M@1090|Chlorobi	1090|Chlorobi	L	PFAM single-strand binding protein Primosomal replication protein n	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
WLSH2_k127_389220_0	411473.RUMCAL_02302	2.085e-08	59.0	COG1051@1|root,COG1051@2|Bacteria,1VAMK@1239|Firmicutes,24MRX@186801|Clostridia,3WRYJ@541000|Ruminococcaceae	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
WLSH2_k127_389220_1	1120998.AUFC01000023_gene2168	4.167e-05	49.0	COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,3WCIM@538999|Clostridiales incertae sedis	186801|Clostridia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
WLSH2_k127_3902611_3	1131266.ARWQ01000001_gene1142	3.117e-29	122.0	COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
WLSH2_k127_3902611_2	1410676.JNKL01000019_gene1424	6.865e-39	149.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1Y3FN@135624|Aeromonadales	135624|Aeromonadales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
WLSH2_k127_3902611_4	1318628.MARLIPOL_06934	9.408e-21	100.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	-	-	1.17.1.1	ko:K00523,ko:K02823	ko00240,ko00520,ko01100,map00240,map00520,map01100	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer2,NAD_binding_1
WLSH2_k127_3902611_1	1158338.JNLJ01000001_gene557	1.391e-47	173.0	COG0468@1|root,COG0468@2|Bacteria,2G3UK@200783|Aquificae	200783|Aquificae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
WLSH2_k127_3902611_0	1026882.MAMP_02513	1.942e-86	290.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,45ZTK@72273|Thiotrichales	72273|Thiotrichales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
WLSH2_k127_3913718_0	639282.DEFDS_0625	6.772e-06	52.0	COG2805@1|root,COG2805@2|Bacteria,2GF8B@200930|Deferribacteres	200930|Deferribacteres	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
WLSH2_k127_3944110_0	667014.Thein_1879	2.491e-14	80.0	COG0781@1|root,COG0781@2|Bacteria,2GHUU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
WLSH2_k127_3944110_1	945713.IALB_1987	9.593e-12	68.0	COG0571@1|root,COG0571@2|Bacteria	2|Bacteria	J	ribonuclease III activity	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
WLSH2_k127_3949919_0	1118054.CAGW01000082_gene3029	4.393e-06	57.0	COG0470@1|root,COG0470@2|Bacteria,1TRVS@1239|Firmicutes,4HA3T@91061|Bacilli,26Q9Y@186822|Paenibacillaceae	91061|Bacilli	L	DNA polymerase III	holB	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
WLSH2_k127_3988773_0	862517.HMPREF9225_1023	4.407e-22	101.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,22HPP@1570339|Peptoniphilaceae	186801|Clostridia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	3.5.4.5	ko:K01489,ko:K07042	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000,ko03009	-	-	-	UPF0054
WLSH2_k127_3988773_1	632245.CLP_0529	2.63e-06	54.0	COG2211@1|root,COG2211@2|Bacteria,1UKKD@1239|Firmicutes,25GE3@186801|Clostridia,36V4C@31979|Clostridiaceae	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH2_k127_4053031_0	1095770.CAHE01000031_gene134	9.281e-32	130.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,22H37@1570339|Peptoniphilaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
WLSH2_k127_4053031_1	716544.wcw_0540	0.0002798	45.0	COG1872@1|root,COG1872@2|Bacteria,2JGG0@204428|Chlamydiae	204428|Chlamydiae	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
WLSH2_k127_4091258_0	228410.NE1823	1.68e-93	316.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,372PH@32003|Nitrosomonadales	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
WLSH2_k127_4145506_1	1183377.Py04_0021	3.396e-23	111.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,243ZB@183968|Thermococci	183968|Thermococci	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
WLSH2_k127_4145506_2	906968.Trebr_1808	2.631e-08	65.0	COG0438@1|root,COG0438@2|Bacteria,2J599@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	ko:K13001	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
WLSH2_k127_4145506_0	1131266.ARWQ01000003_gene1571	3.34e-38	155.0	COG0451@1|root,arCOG01372@2157|Archaea	2157|Archaea	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
WLSH2_k127_4190592_1	222534.KB893718_gene2214	2.284e-21	99.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4ERJ5@85013|Frankiales	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
WLSH2_k127_4190592_0	1176165.CAJD01000012_gene695	4.096e-43	176.0	COG1215@1|root,COG1215@2|Bacteria,2IK1V@201174|Actinobacteria,4F9BY@85019|Brevibacteriaceae	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_4208620_0	1134413.ANNK01000167_gene529	6.585e-20	96.0	COG1825@1|root,COG1825@2|Bacteria,1VA38@1239|Firmicutes,4HIMM@91061|Bacilli,1ZDPJ@1386|Bacillus	91061|Bacilli	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
WLSH2_k127_4208620_2	1235800.C819_01832	0.0001485	45.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,27I7S@186928|unclassified Lachnospiraceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WLSH2_k127_4208620_1	1128398.Curi_c02750	1.491e-18	88.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,2683K@186813|unclassified Clostridiales	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WLSH2_k127_4283997_0	759362.KVU_2507	8.409e-26	112.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS_3,PAS_4,PAS_9
WLSH2_k127_4283997_1	944546.ABED_1188	1.939e-09	64.0	COG5001@1|root,COG5001@2|Bacteria,1R4H0@1224|Proteobacteria,43CII@68525|delta/epsilon subdivisions,2YTD5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
WLSH2_k127_4283997_3	563040.Saut_0084	0.0001385	46.0	COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1Q49C@1224|Proteobacteria,42MW2@68525|delta/epsilon subdivisions,2YNR7@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
WLSH2_k127_4283997_2	1442598.JABW01000031_gene1271	1.288e-05	48.0	COG2200@1|root,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,42S4U@68525|delta/epsilon subdivisions,2YTK1@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	EAL domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL
WLSH2_k127_4292068_0	748449.Halha_0455	1.112e-05	54.0	COG3385@1|root,COG3385@2|Bacteria,1TY08@1239|Firmicutes,24EQW@186801|Clostridia	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
WLSH2_k127_4292068_1	748449.Halha_0455	2.358e-05	49.0	COG3385@1|root,COG3385@2|Bacteria,1TY08@1239|Firmicutes,24EQW@186801|Clostridia	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
WLSH2_k127_4312362_2	221288.JH992901_gene5682	4.492e-14	78.0	COG0586@1|root,COG0586@2|Bacteria,1G184@1117|Cyanobacteria,1JJT8@1189|Stigonemataceae	1117|Cyanobacteria	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
WLSH2_k127_4312362_1	1234409.C683_0464	2.898e-16	91.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H9KT@91061|Bacilli,4AZIV@81852|Enterococcaceae	91061|Bacilli	M	Glycosyl transferase family 4	tagO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
WLSH2_k127_4312362_3	635013.TherJR_1751	1.724e-08	59.0	COG2165@1|root,COG2165@2|Bacteria,1VK8F@1239|Firmicutes,25GH3@186801|Clostridia,267EJ@186807|Peptococcaceae	186801|Clostridia	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
WLSH2_k127_4312362_0	1121104.AQXH01000004_gene23	2.512e-27	118.0	COG0632@1|root,COG0632@2|Bacteria,4NF4E@976|Bacteroidetes	976|Bacteroidetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
WLSH2_k127_4346459_0	243365.CV_1028	1.979e-26	111.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,2KR5B@206351|Neisseriales	206351|Neisseriales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
WLSH2_k127_4346459_1	1188240.MYEA_6840	0.0001351	46.0	COG0262@1|root,COG0262@2|Bacteria,3WTUP@544448|Tenericutes	544448|Tenericutes	H	Dihydrofolate reductase	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
WLSH2_k127_4383875_0	326427.Cagg_0001	4.912e-63	226.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi,3759K@32061|Chloroflexia	32061|Chloroflexia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
WLSH2_k127_4388920_0	511.JT27_18495	6.308e-15	86.0	COG4653@1|root,COG4653@2|Bacteria	2|Bacteria	G	Phage capsid family	gp36	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	Peptidase_S78,Phage_capsid
WLSH2_k127_4388960_0	1405.DJ92_2006	3.846e-52	187.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,4HATY@91061|Bacilli,1ZASX@1386|Bacillus	91061|Bacilli	M	UTP-glucose-1-phosphate uridylyltransferase	gtaB	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WLSH2_k127_4388960_2	656519.Halsa_0451	7.266e-33	132.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,3WAIP@53433|Halanaerobiales	186801|Clostridia	M	PFAM Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WLSH2_k127_4388960_3	1007096.BAGW01000014_gene1180	3.133e-14	85.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1TQBV@1239|Firmicutes,24AWX@186801|Clostridia,2N6AF@216572|Oscillospiraceae	186801|Clostridia	GN	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,NAGPA,SLH
WLSH2_k127_4388960_4	1487953.JMKF01000050_gene2003	3.976e-11	75.0	COG0739@1|root,COG0739@2|Bacteria,1G03M@1117|Cyanobacteria,1H9Z5@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
WLSH2_k127_4388960_1	926569.ANT_05570	1.642e-40	152.0	COG1816@1|root,COG1816@2|Bacteria,2G6AT@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
WLSH2_k127_4400116_0	1442599.JAAN01000031_gene1343	2.218e-154	505.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1X3EG@135614|Xanthomonadales	135614|Xanthomonadales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
WLSH2_k127_4400116_1	1249627.D779_2365	1.727e-74	266.0	COG0840@1|root,COG0840@2|Bacteria,1R486@1224|Proteobacteria,1RZM1@1236|Gammaproteobacteria,1X2BD@135613|Chromatiales	135613|Chromatiales	NT	Chemoreceptor zinc-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CZB,MCPsignal
WLSH2_k127_4471492_0	357808.RoseRS_2181	4.098e-25	109.0	COG1159@1|root,COG1159@2|Bacteria,2G69C@200795|Chloroflexi,3755E@32061|Chloroflexia	32061|Chloroflexia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
WLSH2_k127_447731_1	926550.CLDAP_04260	2.249e-21	95.0	COG0759@1|root,COG0759@2|Bacteria,2G76Q@200795|Chloroflexi	200795|Chloroflexi	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
WLSH2_k127_447731_0	649747.HMPREF0083_02428	1.692e-35	147.0	COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,4HCQF@91061|Bacilli,274RN@186822|Paenibacillaceae	91061|Bacilli	P	Mediates influx of magnesium ions	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
WLSH2_k127_4487549_1	1254432.SCE1572_03990	4.363e-41	156.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2YV5P@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
WLSH2_k127_4487549_0	888727.HMPREF9092_1403	5.281e-97	325.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WCIN@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
WLSH2_k127_4495149_0	706587.Desti_3575	1.105e-111	377.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria,2MSBC@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
WLSH2_k127_4519005_0	1449342.JQMR01000001_gene1317	7.769e-77	277.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli,27F7B@186828|Carnobacteriaceae	91061|Bacilli	S	ABC transporter C-terminal domain	ydiF	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
WLSH2_k127_4576221_0	1392488.JHZY01000004_gene2552	9.389e-11	66.0	COG3021@1|root,COG3021@2|Bacteria,4PMEX@976|Bacteroidetes,1IJRN@117743|Flavobacteriia	976|Bacteroidetes	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
WLSH2_k127_459254_3	1033743.CAES01000061_gene4529	8.232e-09	58.0	COG1733@1|root,COG1733@2|Bacteria,1V622@1239|Firmicutes,4HH7F@91061|Bacilli,275JX@186822|Paenibacillaceae	91061|Bacilli	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
WLSH2_k127_459254_2	215803.DB30_7231	5.415e-10	61.0	COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria,42M2Y@68525|delta/epsilon subdivisions,2WKJG@28221|Deltaproteobacteria,2YUCJ@29|Myxococcales	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	1.6.5.2	ko:K19267	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10,NmrA
WLSH2_k127_459254_0	714943.Mucpa_0634	1.367e-34	136.0	COG0702@1|root,COG0702@2|Bacteria,4NE40@976|Bacteroidetes,1IRWC@117747|Sphingobacteriia	976|Bacteroidetes	GM	NmrA family	-	-	1.6.5.2	ko:K19267	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10,NmrA
WLSH2_k127_459254_1	866536.Belba_1037	2.765e-20	93.0	COG0702@1|root,COG0702@2|Bacteria,4NE40@976|Bacteroidetes,47XJX@768503|Cytophagia	976|Bacteroidetes	GM	NmrA-like family	-	-	1.6.5.2	ko:K19267	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10,NmrA
WLSH2_k127_4595758_0	1321779.HMPREF1984_00956	3.879e-67	233.0	COG0719@1|root,COG0719@2|Bacteria,378VG@32066|Fusobacteria	32066|Fusobacteria	O	feS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
WLSH2_k127_4595758_1	797303.Natpe_2774	1.899e-66	230.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,23S0E@183963|Halobacteria	183963|Halobacteria	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB1	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
WLSH2_k127_4630733_0	511051.CSE_12600	1.62e-19	93.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
WLSH2_k127_4630733_1	694431.DESACE_00730	0.0008684	44.0	COG1502@1|root,COG1502@2|Bacteria,1RK7U@1224|Proteobacteria,42WC8@68525|delta/epsilon subdivisions,2X6NZ@28221|Deltaproteobacteria,2M75H@213113|Desulfurellales	28221|Deltaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
WLSH2_k127_4658158_0	357808.RoseRS_1430	2.884e-38	151.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2G5ZR@200795|Chloroflexi,3753B@32061|Chloroflexia	32061|Chloroflexia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
WLSH2_k127_4658158_5	1117319.PSPO_05226	1.814e-09	62.0	COG2501@1|root,COG2501@2|Bacteria,1N8C4@1224|Proteobacteria,1SCIR@1236|Gammaproteobacteria,2Q2CT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	S4 domain	ybcJ	-	-	ko:K14761	-	-	-	-	ko00000,ko03009	-	-	-	S4_2
WLSH2_k127_4658158_1	485913.Krac_0136	9.559e-38	147.0	COG3451@1|root,COG3451@2|Bacteria	2|Bacteria	U	multi-organism process	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
WLSH2_k127_4658158_2	882083.SacmaDRAFT_4144	5.322e-25	110.0	COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4E1I0@85010|Pseudonocardiales	201174|Actinobacteria	U	Type IV secretory pathway, VirB4	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
WLSH2_k127_4658158_6	478749.BRYFOR_08977	5.262e-09	59.0	COG3451@1|root,COG3451@2|Bacteria,1TQGE@1239|Firmicutes,24ACY@186801|Clostridia	186801|Clostridia	U	COG COG3451 Type IV secretory pathway, VirB4 components	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10
WLSH2_k127_4658158_4	1449355.JQNR01000005_gene4402	6.501e-15	83.0	COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria	201174|Actinobacteria	U	Type IV secretory pathway, VirB4	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
WLSH2_k127_4658158_3	572544.Ilyop_0428	1.582e-21	102.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,378YN@32066|Fusobacteria	32066|Fusobacteria	KT	PFAM Stage II sporulation E family protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_3,Response_reg,SpoIIE
WLSH2_k127_4669754_0	445971.ANASTE_00259	4.216e-42	159.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,25URN@186806|Eubacteriaceae	186801|Clostridia	O	Mg chelatase-like protein	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
WLSH2_k127_4675246_0	1184267.A11Q_716	1.396e-60	221.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2MSP6@213481|Bdellovibrionales,2WJ3W@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WLSH2_k127_4716533_0	944479.JQLX01000011_gene838	4.742e-41	162.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2WIQ9@28221|Deltaproteobacteria,2M6H6@213113|Desulfurellales	28221|Deltaproteobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
WLSH2_k127_4716533_6	296587.XP_002501542.1	0.0003507	45.0	COG0462@1|root,KOG1448@2759|Eukaryota,37M9U@33090|Viridiplantae,34HBP@3041|Chlorophyta	3041|Chlorophyta	EF	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran,Pribosyltran_N
WLSH2_k127_4716533_4	38833.XP_003057964.1	6.458e-10	60.0	COG0462@1|root,KOG1448@2759|Eukaryota,37M9U@33090|Viridiplantae,34HBP@3041|Chlorophyta	3041|Chlorophyta	EF	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran,Pribosyltran_N
WLSH2_k127_4716533_2	85681.XP_006437182.1	1.73e-16	81.0	COG0462@1|root,KOG1448@2759|Eukaryota,37M9U@33090|Viridiplantae,3G96U@35493|Streptophyta	35493|Streptophyta	EF	ribose-phosphate pyrophosphokinase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0009506,GO:0016020,GO:0030054,GO:0044424,GO:0044444,GO:0044464,GO:0055044,GO:0071944	-	-	-	-	-	-	-	-	-	-	Pribosyltran,Pribosyltran_N
WLSH2_k127_4716533_3	6087.XP_002154050.1	6.026e-14	75.0	COG0462@1|root,KOG1448@2759|Eukaryota,39XAP@33154|Opisthokonta,3BMTX@33208|Metazoa	33208|Metazoa	EF	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran,Pribosyltran_N
WLSH2_k127_4716533_1	1408312.JNJS01000008_gene570	8.366e-31	124.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,3NGV4@46205|Pseudobutyrivibrio	186801|Clostridia	F	Phosphoribosyl transferase domain	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
WLSH2_k127_4716533_5	262719.MHJ_0110	1.58e-08	64.0	COG0503@1|root,COG0503@2|Bacteria,3WTCR@544448|Tenericutes	544448|Tenericutes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
WLSH2_k127_4725598_0	1347392.CCEZ01000025_gene3236	9.692e-09	64.0	COG0568@1|root,COG0568@2|Bacteria,1VR00@1239|Firmicutes,24J3A@186801|Clostridia,36IV2@31979|Clostridiaceae	186801|Clostridia	K	Sigma-70, region 4	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
WLSH2_k127_4783024_0	515635.Dtur_0873	2.416e-29	121.0	COG2804@1|root,COG2804@2|Bacteria	2|Bacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	ctsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
WLSH2_k127_4792977_0	1120985.AUMI01000004_gene1358	8.479e-245	782.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4H26H@909932|Negativicutes	909932|Negativicutes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
WLSH2_k127_4792977_1	1070319.CAGGBEG34_20026	0.000607	47.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,1K979@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
WLSH2_k127_4824634_0	1370122.JHXQ01000008_gene1887	4.053e-06	57.0	COG1488@1|root,COG1488@2|Bacteria,1MWA2@1224|Proteobacteria,2TYYE@28211|Alphaproteobacteria,4BBAA@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	-	2.4.2.12	ko:K03462	ko00760,ko01100,ko04621,map00760,map01100,map04621	-	R01271	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
WLSH2_k127_484017_1	357808.RoseRS_2190	6.341e-15	83.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1
WLSH2_k127_484017_0	244582.JQAK01000001_gene943	1.618e-24	112.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
WLSH2_k127_4859357_4	190650.CC_0174	7.002e-15	79.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2TRMU@28211|Alphaproteobacteria,2KF4Y@204458|Caulobacterales	204458|Caulobacterales	NU	pathway protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
WLSH2_k127_4859357_3	1347368.HG964407_gene6819	8.278e-22	96.0	COG1162@1|root,COG1162@2|Bacteria,1V272@1239|Firmicutes,4HPS4@91061|Bacilli	91061|Bacilli	S	RNHCP domain	-	-	-	-	-	-	-	-	-	-	-	-	RNHCP
WLSH2_k127_4859357_5	1121342.AUCO01000022_gene3009	7.843e-12	67.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,36EWX@31979|Clostridiaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
WLSH2_k127_4859357_2	1158294.JOMI01000005_gene3227	2.95e-25	111.0	COG0037@1|root,COG0037@2|Bacteria,4NEJS@976|Bacteroidetes,2FP2A@200643|Bacteroidia	976|Bacteroidetes	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
WLSH2_k127_4859357_1	1158345.JNLL01000001_gene2037	2.004e-28	122.0	COG0758@1|root,COG0758@2|Bacteria,2G3ZI@200783|Aquificae	200783|Aquificae	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
WLSH2_k127_4859357_0	1408439.JHXW01000004_gene1324	5.322e-30	124.0	COG0758@1|root,COG0758@2|Bacteria,378EC@32066|Fusobacteria	32066|Fusobacteria	LU	Psort location Cytoplasmic, score 8.96	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
WLSH2_k127_4906716_3	208960.XP_007265813.1	8.343e-08	59.0	28N75@1|root,2QUSF@2759|Eukaryota,3A77U@33154|Opisthokonta,3P5YA@4751|Fungi,3V211@5204|Basidiomycota,22EKF@155619|Agaricomycetes	4751|Fungi	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,NT5C
WLSH2_k127_4906716_1	592029.DDD_0030	4.549e-21	95.0	COG0482@1|root,COG0482@2|Bacteria,4NFXZ@976|Bacteroidetes,1HWQ1@117743|Flavobacteriia,3HK3A@363408|Nonlabens	976|Bacteroidetes	J	tRNA methyl transferase	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
WLSH2_k127_4906716_2	641149.HMPREF9016_00670	1.483e-10	63.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,2KPM8@206351|Neisseriales	206351|Neisseriales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	trmU	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
WLSH2_k127_4906716_0	1449063.JMLS01000012_gene5532	5.406e-60	213.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4HBJ6@91061|Bacilli,26SES@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
WLSH2_k127_4932404_0	1382356.JQMP01000003_gene1710	1.006e-80	281.0	COG0820@1|root,COG0820@2|Bacteria,2G5SD@200795|Chloroflexi,27XRH@189775|Thermomicrobia	189775|Thermomicrobia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
WLSH2_k127_4963425_1	558884.JRGM01000178_gene2604	8.385e-06	50.0	COG2755@1|root,COG2755@2|Bacteria,1QV1E@1224|Proteobacteria	1224|Proteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_fiber_2,SASA
WLSH2_k127_4963425_0	1292035.H476_2996	2.515e-06	51.0	COG5492@1|root,COG5492@2|Bacteria,1V17S@1239|Firmicutes,24GRG@186801|Clostridia	186801|Clostridia	N	S-layer domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,SLH
WLSH2_k127_4993534_0	1120746.CCNL01000011_gene1772	2.708e-20	96.0	COG0564@1|root,COG0564@2|Bacteria,2NNY5@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.23,5.4.99.24	ko:K06179,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WLSH2_k127_5018682_0	1123517.JOMR01000001_gene1613	6.341e-16	83.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,GAF,GAF_2,Guanylate_cyc,HAMP,PAS_9,dCache_1
WLSH2_k127_5077137_4	316067.Geob_2957	1.05e-06	51.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2X7PN@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	S	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
WLSH2_k127_5077137_5	86416.Clopa_0859	6.113e-05	49.0	COG0463@1|root,COG0463@2|Bacteria,1UI7F@1239|Firmicutes,25ECR@186801|Clostridia,36UKG@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WLSH2_k127_5077137_1	1392493.JIAB01000001_gene1746	5.554e-26	118.0	COG1215@1|root,COG1215@2|Bacteria,1UIBE@1239|Firmicutes,25EGF@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WLSH2_k127_5077137_0	756272.Plabr_1771	6.767e-41	160.0	COG1215@1|root,COG1215@2|Bacteria,2J52E@203682|Planctomycetes	203682|Planctomycetes	M	involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WLSH2_k127_5077137_3	647113.Metok_0675	1.733e-07	57.0	COG2456@1|root,arCOG05092@2157|Archaea,2XZCE@28890|Euryarchaeota,23R5T@183939|Methanococci	183939|Methanococci	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
WLSH2_k127_5077137_2	44251.PDUR_24690	1.718e-08	59.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,26QG8@186822|Paenibacillaceae	91061|Bacilli	M	penicillin-binding protein	pbpF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.4.1.129,3.4.16.4	ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
WLSH2_k127_5082503_1	1123284.KB899043_gene140	2.149e-23	105.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,4HBX7@91061|Bacilli,26P8M@186821|Sporolactobacillaceae	91061|Bacilli	KT	HD domain	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iYO844.BSU27600	ACT_4,HD_4,RelA_SpoT,TGS
WLSH2_k127_5082503_0	1304885.AUEY01000050_gene1197	2.237e-69	243.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
WLSH2_k127_5101932_0	1410630.JNKP01000001_gene2204	1.967e-63	231.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,27J5T@186928|unclassified Lachnospiraceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
WLSH2_k127_5102149_0	289376.THEYE_A1448	1.056e-195	616.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
WLSH2_k127_5102149_3	926569.ANT_10030	4.629e-28	117.0	COG0051@1|root,COG0051@2|Bacteria,2G6RB@200795|Chloroflexi	200795|Chloroflexi	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WLSH2_k127_5102149_4	755732.Fluta_2697	4.771e-17	82.0	COG0227@1|root,COG0227@2|Bacteria,4NS7Q@976|Bacteroidetes,1I3YG@117743|Flavobacteriia,2PB6U@246874|Cryomorphaceae	976|Bacteroidetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
WLSH2_k127_5102149_5	688269.Theth_0790	2.467e-12	70.0	COG0228@1|root,COG0228@2|Bacteria,2GD7M@200918|Thermotogae	200918|Thermotogae	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
WLSH2_k127_5102149_6	264201.pc0357	2.717e-11	66.0	COG1837@1|root,COG1837@2|Bacteria,2JGBY@204428|Chlamydiae	204428|Chlamydiae	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
WLSH2_k127_5102149_1	697281.Mahau_2357	2.215e-116	390.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
WLSH2_k127_5102149_2	697284.ERIC2_c38800	9.36e-77	264.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli,26RRK@186822|Paenibacillaceae	91061|Bacilli	O	Belongs to the ClpA ClpB family	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
WLSH2_k127_511486_0	649349.Lbys_1940	7.102e-62	228.0	COG4487@1|root,COG4487@2|Bacteria,4NGZ9@976|Bacteroidetes,47MY2@768503|Cytophagia	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2130)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
WLSH2_k127_5148813_3	382464.ABSI01000005_gene1243	9.598e-06	50.0	COG0358@1|root,COG0358@2|Bacteria,46S6C@74201|Verrucomicrobia,2ITUJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
WLSH2_k127_5148813_2	1357400.HMPREF2086_00852	3.872e-22	97.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2YMJR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaGprimase_HBD,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
WLSH2_k127_5148813_4	936140.AEOT01000020_gene1545	2.074e-05	47.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,4HAG2@91061|Bacilli,3F3N1@33958|Lactobacillaceae	91061|Bacilli	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
WLSH2_k127_5148813_0	865861.AZSU01000003_gene2059	1.841e-48	181.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,36E45@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
WLSH2_k127_5148813_1	1121335.Clst_1328	3.797e-48	175.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,3WNX9@541000|Ruminococcaceae	186801|Clostridia	K	Sigma-70 factor, region 1.2	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
WLSH2_k127_5164965_0	1348635.BBJY01000005_gene3257	2.136e-57	217.0	COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1NAY1@1224|Proteobacteria,1RP74@1236|Gammaproteobacteria,1XSE4@135623|Vibrionales	135623|Vibrionales	J	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA	rsmF	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.178	ko:K11392	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA
WLSH2_k127_5164965_1	634452.APA01_12080	1.234e-46	178.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2TURK@28211|Alphaproteobacteria,2JSEZ@204441|Rhodospirillales	204441|Rhodospirillales	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
WLSH2_k127_5211560_0	933262.AXAM01000023_gene658	1.003e-26	116.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
WLSH2_k127_5211560_2	592031.GCWU000322_00678	0.0001814	51.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,25V2U@186806|Eubacteriaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
WLSH2_k127_5211560_1	866536.Belba_0589	3.657e-05	46.0	2E8MC@1|root,332YU@2|Bacteria,4NUZI@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_5215011_1	386415.NT01CX_1296	2.1e-69	247.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
WLSH2_k127_5215011_0	1121930.AQXG01000001_gene1270	2.291e-120	397.0	COG0587@1|root,COG0587@2|Bacteria,4NFA0@976|Bacteroidetes,1IR52@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
WLSH2_k127_5215011_2	479433.Caci_7110	1.022e-21	97.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
WLSH2_k127_5276089_0	455436.DS989810_gene304	1.074e-05	59.0	2DBDK@1|root,2Z8MH@2|Bacteria	2|Bacteria	S	BNR repeat-containing family member	-	-	-	-	-	-	-	-	-	-	-	-	BNR_4
WLSH2_k127_5306802_0	929713.NIASO_08590	1.974e-09	59.0	COG0566@1|root,COG0566@2|Bacteria,4NM8C@976|Bacteroidetes,1IS2Z@117747|Sphingobacteriia	976|Bacteroidetes	J	SpoU rRNA Methylase family	spoU	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
WLSH2_k127_5327827_0	745411.B3C1_08676	1.864e-81	287.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1J4C1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	histidyl-tRNA synthetase	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	HGTP_anticodon,tRNA-synt_His
WLSH2_k127_5327827_4	1408473.JHXO01000013_gene536	1.267e-06	53.0	COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes,2FMZT@200643|Bacteroidia	976|Bacteroidetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WLSH2_k127_5327827_3	743719.PaelaDRAFT_1543	2.167e-11	68.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,4H9NN@91061|Bacilli,26QET@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WLSH2_k127_5327827_2	1158294.JOMI01000007_gene212	3.481e-33	130.0	COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes,2FMZT@200643|Bacteroidia	976|Bacteroidetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WLSH2_k127_5327827_1	411490.ANACAC_02006	5.296e-53	190.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WLSH2_k127_5353611_0	525904.Tter_0176	6.09e-111	377.0	COG0143@1|root,COG0143@2|Bacteria,2NNTX@2323|unclassified Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
WLSH2_k127_5432045_0	990073.ATHU01000001_gene761	3.512e-39	152.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2YN57@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
WLSH2_k127_5432045_1	1321778.HMPREF1982_01552	3.739e-08	59.0	COG1309@1|root,COG1309@2|Bacteria,1VFD2@1239|Firmicutes,24KBF@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
WLSH2_k127_5432045_2	675806.VII_002067	8.12e-07	53.0	COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1XU26@135623|Vibrionales	135623|Vibrionales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
WLSH2_k127_5485173_1	1304888.ATWF01000001_gene706	2.571e-34	138.0	COG1459@1|root,COG1459@2|Bacteria,2GF20@200930|Deferribacteres	200930|Deferribacteres	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
WLSH2_k127_5485173_0	700598.Niako_5466	1.893e-50	184.0	COG0313@1|root,COG0313@2|Bacteria,4NFQM@976|Bacteroidetes,1IPC1@117747|Sphingobacteriia	976|Bacteroidetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
WLSH2_k127_5495053_1	926561.KB900621_gene2861	1.084e-12	72.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,3WAGN@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
WLSH2_k127_5495053_0	755178.Cyan10605_1695	1.293e-48	182.0	COG0042@1|root,COG0042@2|Bacteria,1G0PN@1117|Cyanobacteria	1117|Cyanobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
WLSH2_k127_5571748_0	1078020.KEK_12748	7.863e-150	484.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,234DS@1762|Mycobacteriaceae	201174|Actinobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WLSH2_k127_5580084_0	439235.Dalk_1768	5.209e-08	63.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria,2MIZH@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
WLSH2_k127_565297_1	485913.Krac_12284	5.578e-13	78.0	COG0849@1|root,COG0849@2|Bacteria	2|Bacteria	D	cell division	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
WLSH2_k127_565297_2	1427984.X271_00059	0.0004132	43.0	COG0533@1|root,COG0533@2|Bacteria,3WSXH@544448|Tenericutes	544448|Tenericutes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	gcp	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WLSH2_k127_565297_0	469596.HMPREF9488_00826	6.391e-28	116.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,3VPN2@526524|Erysipelotrichia	526524|Erysipelotrichia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WLSH2_k127_5690636_1	591001.Acfer_1585	0.0005841	51.0	COG3409@1|root,COG3584@1|root,COG3409@2|Bacteria,COG3584@2|Bacteria,1UV4J@1239|Firmicutes,4H4W0@909932|Negativicutes	909932|Negativicutes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	3D,PG_binding_1
WLSH2_k127_5690636_0	1123239.KB898626_gene674	0.0004408	52.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,4ISYS@91061|Bacilli	91061|Bacilli	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
WLSH2_k127_5750518_0	8153.XP_005929556.1	1.683e-15	81.0	KOG3128@1|root,KOG3128@2759|Eukaryota,39AX7@33154|Opisthokonta,3BGKK@33208|Metazoa,3CYGM@33213|Bilateria,482AP@7711|Chordata,495DP@7742|Vertebrata,49V44@7898|Actinopterygii	33208|Metazoa	S	5'-nucleotidase, cytosolic IIIA	NT5C3A	GO:0000215,GO:0000287,GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009123,GO:0009125,GO:0009158,GO:0009161,GO:0009164,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0012505,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042578,GO:0043167,GO:0043169,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046128,GO:0046130,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:0098542,GO:0140098,GO:0140101,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	UMPH-1
WLSH2_k127_5750518_1	13616.ENSMODP00000018406	0.0001123	48.0	KOG3128@1|root,KOG3128@2759|Eukaryota,39AX7@33154|Opisthokonta,3BGKK@33208|Metazoa,3D2VG@33213|Bilateria,4863A@7711|Chordata,4971B@7742|Vertebrata,3JBX4@40674|Mammalia,4JWIT@9263|Metatheria	33208|Metazoa	F	5'-nucleotidase, cytosolic IIIB	NT5C3B	GO:0000288,GO:0000291,GO:0000956,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006401,GO:0006402,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009057,GO:0009058,GO:0009116,GO:0009119,GO:0009123,GO:0009125,GO:0009158,GO:0009161,GO:0009164,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042578,GO:0043170,GO:0043928,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046434,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072521,GO:0072523,GO:0090304,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	UMPH-1
WLSH2_k127_5784433_0	502025.Hoch_0824	1.073e-24	114.0	COG1793@1|root,COG4643@1|root,COG1793@2|Bacteria,COG4643@2|Bacteria,1R6M4@1224|Proteobacteria,43ASY@68525|delta/epsilon subdivisions,2X678@28221|Deltaproteobacteria,2Z3A0@29|Myxococcales	28221|Deltaproteobacteria	L	dna ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_5914741_0	386456.JQKN01000009_gene1162	3.989e-06	49.0	COG1520@1|root,COG3291@1|root,arCOG02516@1|root,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea	2157|Archaea	G	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,Big_5,CHB_HEX_C_1,PKD,PMBR,PQQ_3
WLSH2_k127_5928810_2	1500306.JQLA01000029_gene231	3.169e-08	63.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2U5HG@28211|Alphaproteobacteria,4BBID@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
WLSH2_k127_5928810_1	457421.CBFG_05839	3.038e-14	74.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
WLSH2_k127_5928810_0	1347392.CCEZ01000007_gene1957	3.507e-33	132.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,36FMV@31979|Clostridiaceae	186801|Clostridia	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
WLSH2_k127_6053983_0	694431.DESACE_01185	3.735e-97	323.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2M6AX@213113|Desulfurellales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
WLSH2_k127_6081658_0	1499967.BAYZ01000152_gene1394	0.0009002	51.0	COG2373@1|root,COG2373@2|Bacteria,2NQA2@2323|unclassified Bacteria	2|Bacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
WLSH2_k127_6096822_1	580340.Tlie_1608	7.56e-11	66.0	COG1804@1|root,COG1804@2|Bacteria,3T9W8@508458|Synergistetes	508458|Synergistetes	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
WLSH2_k127_6096822_2	10042.XP_006980203.1	0.0002316	45.0	COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3BB7M@33208|Metazoa,3D0JC@33213|Bilateria,4838Z@7711|Chordata,48ZTZ@7742|Vertebrata,3JBNC@40674|Mammalia,35AGG@314146|Euarchontoglires,4Q38P@9989|Rodentia	33208|Metazoa	I	succinate-hydroxymethylglutarate CoA-transferase activity	SUGCT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0008410,GO:0016740,GO:0016782,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0047369	2.8.3.13	ko:K18703	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
WLSH2_k127_6096822_0	748280.NH8B_4001	2.67e-29	121.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KRVU@206351|Neisseriales	206351|Neisseriales	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
WLSH2_k127_6119364_2	1157490.EL26_07490	1.528e-22	99.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,4HAA4@91061|Bacilli	91061|Bacilli	C	Catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	PFO_beta_C,TPP_enzyme_C
WLSH2_k127_6119364_1	273075.Ta0772m	9.63e-25	106.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUA1@28890|Euryarchaeota,241UV@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
WLSH2_k127_6119364_9	456442.Mboo_0730	0.0003888	47.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,2N9RY@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH2_k127_6119364_6	1265505.ATUG01000001_gene3143	8.851e-08	56.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria,2MI7V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH2_k127_6119364_0	485913.Krac_6794	5.615e-27	114.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
WLSH2_k127_6119364_7	289376.THEYE_A0984	2.007e-07	55.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
WLSH2_k127_6119364_8	1380355.JNIJ01000014_gene569	0.0003627	47.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,3JUZI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
WLSH2_k127_6119364_5	1450694.BTS2_1892	1.063e-12	71.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,4HBXF@91061|Bacilli,1ZBZD@1386|Bacillus	91061|Bacilli	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
WLSH2_k127_6119364_4	28072.Nos7524_2523	1.825e-15	77.0	COG1091@1|root,COG1091@2|Bacteria,1G1CP@1117|Cyanobacteria,1HMCP@1161|Nostocales	1117|Cyanobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.rfbD	RmlD_sub_bind
WLSH2_k127_6119364_3	1123312.KB904583_gene1471	8.811e-16	79.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,4HBXF@91061|Bacilli	91061|Bacilli	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
WLSH2_k127_6137201_2	1183438.GKIL_0090	6.202e-06	54.0	COG1277@1|root,COG1277@2|Bacteria,1G09F@1117|Cyanobacteria	1117|Cyanobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
WLSH2_k127_6137201_1	1347087.CBYO010000007_gene1192	2.969e-08	55.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,4HC6W@91061|Bacilli	91061|Bacilli	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
WLSH2_k127_6137201_0	1089553.Tph_c27550	1.734e-10	68.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,42F18@68295|Thermoanaerobacterales	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
WLSH2_k127_6185591_1	498761.HM1_1406	9.742e-49	181.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
WLSH2_k127_6185591_3	547144.HydHO_0290	3.226e-34	135.0	COG0100@1|root,COG0100@2|Bacteria,2G43F@200783|Aquificae	200783|Aquificae	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
WLSH2_k127_6185591_2	1123354.AUDR01000018_gene1230	1.723e-39	149.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2VR2K@28216|Betaproteobacteria,1KRQ5@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
WLSH2_k127_6185591_5	1367491.BN865_05530c	3.561e-15	76.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2YQQ9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
WLSH2_k127_6185591_4	745411.B3C1_00940	4.347e-20	92.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1J6G9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
WLSH2_k127_6185591_6	1121020.JIAG01000001_gene1214	2.574e-10	64.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,1W7T9@1268|Micrococcaceae	201174|Actinobacteria	K	Crp Fnr family	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
WLSH2_k127_6185591_0	1227352.C173_17291	4.491e-83	280.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,271UU@186822|Paenibacillaceae	91061|Bacilli	J	tRNA synthetases class II (A)	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_2c,tRNA_SAD
WLSH2_k127_6201108_2	631454.N177_2277	4.895e-10	61.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,1JNBR@119043|Rhodobiaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA	-	-	ko:K02021,ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH2_k127_6201108_0	1033743.CAES01000045_gene134	4.049e-34	134.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,26QA9@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	ygaD	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
WLSH2_k127_6201108_3	1007103.AFHW01000035_gene1910	7.037e-07	50.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HAZP@91061|Bacilli,26QJW@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH2_k127_6201108_4	1121403.AUCV01000002_gene484	0.000307	45.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,1R3RU@1224|Proteobacteria	1224|Proteobacteria	EH	chorismate binding enzyme	ehpC	-	2.6.1.86	ko:K13063	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	R08956	RC00010,RC02387	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind,GATase
WLSH2_k127_6201108_1	1122182.KB903823_gene1388	5.136e-31	130.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,2GJ8N@201174|Actinobacteria,4DBN5@85008|Micromonosporales	201174|Actinobacteria	EH	chorismate binding enzyme	phzE	-	2.6.1.86	ko:K13063	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	R08956	RC00010,RC02387	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind,GATase
WLSH2_k127_6227204_1	633.DJ40_1982	7.48e-10	62.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,41FKK@629|Yersinia	1236|Gammaproteobacteria	S	T6A_YjeE tRNA threonylcarbamoyl adenosine modification protein YjeE	yjeE	GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
WLSH2_k127_6227204_0	1189612.A33Q_2425	9.584e-47	174.0	COG0741@1|root,COG0741@2|Bacteria,4NH4W@976|Bacteroidetes,47MKU@768503|Cytophagia	976|Bacteroidetes	M	Transglycosylase SLT domain	mltD_2	-	-	-	-	-	-	-	-	-	-	-	SLT
WLSH2_k127_6239383_0	243274.THEMA_04315	5.545e-92	311.0	COG0536@1|root,COG0536@2|Bacteria,2GCFB@200918|Thermotogae	200918|Thermotogae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
WLSH2_k127_6239383_1	1121101.HMPREF1532_02102	1.003e-09	61.0	COG0776@1|root,COG0776@2|Bacteria,4NSK6@976|Bacteroidetes,2FTWW@200643|Bacteroidia,4ARQ9@815|Bacteroidaceae	976|Bacteroidetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
WLSH2_k127_6240423_3	29581.BW37_02654	1.61e-17	81.0	COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,2VHN3@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
WLSH2_k127_6240423_5	1497679.EP56_03140	1.392e-08	55.0	COG0692@1|root,COG0692@2|Bacteria,1TPSN@1239|Firmicutes,4HG5F@91061|Bacilli,26M61@186820|Listeriaceae	91061|Bacilli	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
WLSH2_k127_6240423_1	1198452.Jab_1c01850	2.191e-32	126.0	COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,2VHN3@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
WLSH2_k127_6240423_2	1378168.N510_02211	1.403e-18	89.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes	1239|Firmicutes	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
WLSH2_k127_6240423_4	519441.Smon_0984	5.079e-15	76.0	COG0817@1|root,COG0817@2|Bacteria,37A4F@32066|Fusobacteria	32066|Fusobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
WLSH2_k127_6240423_0	869209.Tresu_0461	1.038e-151	491.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WLSH2_k127_6308585_0	269799.Gmet_0175	5.808e-54	196.0	COG0791@1|root,COG0791@2|Bacteria,1NRCV@1224|Proteobacteria,42YTE@68525|delta/epsilon subdivisions,2WUEN@28221|Deltaproteobacteria,43U28@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_6308585_1	469616.FMAG_00767	5.641e-45	167.0	COG0208@1|root,COG0208@2|Bacteria,378I2@32066|Fusobacteria	32066|Fusobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
WLSH2_k127_6337114_3	768706.Desor_4294	3.135e-08	55.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,263T6@186807|Peptococcaceae	186801|Clostridia	S	ABC transporter C-terminal domain	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
WLSH2_k127_6337114_2	1545701.LACWKB10_1322	1.357e-18	88.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli,3F3QI@33958|Lactobacillaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	ydiF	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
WLSH2_k127_6337114_0	1122149.BACN01000027_gene1528	1.878e-27	118.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli,3F3QI@33958|Lactobacillaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
WLSH2_k127_6337114_1	1238184.CM001792_gene385	1.492e-23	104.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4H9ZK@91061|Bacilli,23K45@182709|Oceanobacillus	91061|Bacilli	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
WLSH2_k127_6340495_5	1330700.JQNC01000003_gene1418	6.312e-15	75.0	COG0096@1|root,COG0096@2|Bacteria,1WK0N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
WLSH2_k127_6340495_1	1283287.KB822575_gene140	5.368e-51	186.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4DNFZ@85009|Propionibacteriales	201174|Actinobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
WLSH2_k127_6340495_3	879243.Poras_0353	4.647e-32	128.0	COG0256@1|root,COG0256@2|Bacteria,4NQAS@976|Bacteroidetes,2FSHX@200643|Bacteroidia,22Y3P@171551|Porphyromonadaceae	976|Bacteroidetes	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
WLSH2_k127_6340495_2	428126.CLOSPI_01586	3.804e-36	146.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,3VQ7N@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
WLSH2_k127_6340495_4	906968.Trebr_2276	2.584e-28	119.0	COG0200@1|root,COG0200@2|Bacteria,2J7ZW@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
WLSH2_k127_6340495_0	309801.trd_0965	8.131e-87	303.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi,27XI1@189775|Thermomicrobia	189775|Thermomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
WLSH2_k127_6359447_0	1120998.AUFC01000017_gene140	2.735e-15	78.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,3WCKF@538999|Clostridiales incertae sedis	186801|Clostridia	FG	HIT domain	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
WLSH2_k127_6372766_0	1121422.AUMW01000005_gene582	3.334e-41	158.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,260X6@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WLSH2_k127_6397676_1	5888.CAK93203	1.756e-14	83.0	COG0659@1|root,2T2NQ@2759|Eukaryota,3ZFFC@5878|Ciliophora	5878|Ciliophora	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
WLSH2_k127_6397676_2	1122176.KB903587_gene4426	3.001e-14	83.0	COG0659@1|root,COG0659@2|Bacteria,4NFX2@976|Bacteroidetes,1IW25@117747|Sphingobacteriia	976|Bacteroidetes	P	COG0659 Sulfate permease and related	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
WLSH2_k127_6397676_0	864565.HMPREF0379_1444	1.666e-84	287.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,25QU2@186804|Peptostreptococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
WLSH2_k127_6432391_2	931276.Cspa_c34350	4.77e-17	81.0	COG0635@1|root,COG1051@1|root,COG0635@2|Bacteria,COG1051@2|Bacteria,1UZNM@1239|Firmicutes,249M8@186801|Clostridia,36R7U@31979|Clostridiaceae	186801|Clostridia	FH	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Radical_SAM
WLSH2_k127_6432391_0	1280686.AUKE01000014_gene609	8.387e-45	167.0	COG0635@1|root,COG1051@1|root,COG0635@2|Bacteria,COG1051@2|Bacteria,1TST7@1239|Firmicutes,249C3@186801|Clostridia,4BXVE@830|Butyrivibrio	186801|Clostridia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Radical_SAM
WLSH2_k127_6438168_0	1123376.AUIU01000012_gene1614	1.495e-68	238.0	COG1418@1|root,COG1418@2|Bacteria,3J0C8@40117|Nitrospirae	40117|Nitrospirae	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
WLSH2_k127_6438168_1	744872.Spica_2759	6.946e-37	141.0	COG1418@1|root,COG1418@2|Bacteria,2J5IM@203691|Spirochaetes	203691|Spirochaetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
WLSH2_k127_6443290_0	1120998.AUFC01000001_gene1708	7.397e-23	100.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,3WCHY@538999|Clostridiales incertae sedis	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
WLSH2_k127_6443290_2	331869.BAL199_15293	1.232e-06	54.0	2A9WW@1|root,30Z4Z@2|Bacteria,1PM1G@1224|Proteobacteria,2UWN1@28211|Alphaproteobacteria,4BT5B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_6443290_1	379066.GAU_1176	5.502e-11	68.0	COG2385@1|root,COG2385@2|Bacteria,1ZT25@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
WLSH2_k127_6443290_3	1713.JOFV01000002_gene592	1.818e-05	50.0	COG2385@1|root,COG5479@1|root,COG5640@1|root,COG2385@2|Bacteria,COG5479@2|Bacteria,COG5640@2|Bacteria,2GNDB@201174|Actinobacteria,4F2JD@85016|Cellulomonadaceae	201174|Actinobacteria	DM	Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme.	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,FG-GAP
WLSH2_k127_6447247_0	838561.P344_07020	1.835e-20	95.0	COG0030@1|root,COG0030@2|Bacteria,3WTCB@544448|Tenericutes	544448|Tenericutes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
WLSH2_k127_6447247_1	335992.SAR11_0710	1.436e-14	77.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,4BQ10@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
WLSH2_k127_6447247_2	5762.XP_002671093.1	0.0002445	46.0	COG0071@1|root,KOG0710@2759|Eukaryota	2759|Eukaryota	O	response to heat	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K07200,ko:K13993	ko04068,ko04141,ko04152,ko04211,ko04213,ko04371,ko04530,ko04710,ko04714,ko04910,ko04920,ko04921,ko04922,ko04931,ko04932,ko05410,map04068,map04141,map04152,map04211,map04213,map04371,map04530,map04710,map04714,map04910,map04920,map04921,map04922,map04931,map04932,map05410	-	-	-	ko00000,ko00001,ko03110	-	-	-	CBS,HSP20
WLSH2_k127_6455489_2	187272.Mlg_0745	1.396e-48	182.0	COG1051@1|root,COG4111@1|root,COG1051@2|Bacteria,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,1T1QN@1236|Gammaproteobacteria,1WYUW@135613|Chromatiales	135613|Chromatiales	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH2_k127_6455489_3	1229783.C273_02950	2.78e-19	96.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,4HII9@91061|Bacilli,4GXC9@90964|Staphylococcaceae	91061|Bacilli	L	Belongs to the Nudix hydrolase family	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS07540,iYO844.BSU23610	NUDIX
WLSH2_k127_6455489_5	759914.BP951000_0112	1.42e-12	75.0	COG1057@1|root,COG1057@2|Bacteria,2J65I@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
WLSH2_k127_6455489_4	272947.RP440	7.879e-13	72.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,47F5E@766|Rickettsiales	766|Rickettsiales	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
WLSH2_k127_6455489_6	335541.Swol_0584	3.149e-05	46.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,42JYG@68298|Syntrophomonadaceae	186801|Clostridia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
WLSH2_k127_6455489_0	349161.Dred_1460	1.661e-70	250.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,25ZY1@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	-	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
WLSH2_k127_6455489_1	927704.SELR_17760	1.286e-57	207.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,4H27N@909932|Negativicutes	909932|Negativicutes	H	NAD( ) synthase glutamine-hydrolyzing	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
WLSH2_k127_6466468_0	1047013.AQSP01000118_gene1252	3.172e-121	415.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_6495162_1	742743.HMPREF9453_01611	2.032e-11	64.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,4H32E@909932|Negativicutes	909932|Negativicutes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
WLSH2_k127_6495162_0	1313301.AUGC01000003_gene2006	3.529e-176	569.0	COG0481@1|root,COG0481@2|Bacteria,4NEJ9@976|Bacteroidetes	976|Bacteroidetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
WLSH2_k127_6530342_0	314345.SPV1_03128	2.096e-49	190.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria	1224|Proteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtC	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
WLSH2_k127_6560493_1	1485544.JQKP01000001_gene1135	1.379e-09	60.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,44V49@713636|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
WLSH2_k127_6560493_0	484770.UFO1_3117	2.865e-36	142.0	COG1051@1|root,COG1051@2|Bacteria,1V7E6@1239|Firmicutes,4H4XZ@909932|Negativicutes	909932|Negativicutes	F	Hydrolase, NUDIX family	-	-	3.6.1.55,3.6.1.56	ko:K03574,ko:K17816	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH2_k127_6564531_0	1410608.JNKX01000019_gene2758	1.573e-45	169.0	COG0608@1|root,COG0608@2|Bacteria,4NDW1@976|Bacteroidetes,2FMH0@200643|Bacteroidia,4AMVJ@815|Bacteroidaceae	976|Bacteroidetes	L	single-stranded-DNA-specific exonuclease recJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WLSH2_k127_6564531_1	235909.GK0594	1.427e-05	48.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4HU64@91061|Bacilli,1WHE6@129337|Geobacillus	91061|Bacilli	L	DHH family	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WLSH2_k127_6564531_2	641491.DND132_3355	3.922e-05	47.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2WJE3@28221|Deltaproteobacteria,2M7W3@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WLSH2_k127_6734336_0	436114.SYO3AOP1_1153	1.534e-68	241.0	COG0149@1|root,COG0149@2|Bacteria,2G4FH@200783|Aquificae	200783|Aquificae	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
WLSH2_k127_6765870_1	1540257.JQMW01000009_gene3151	2.566e-25	109.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,36DG2@31979|Clostridiaceae	186801|Clostridia	NU	type II secretion system protein E	xcpR	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
WLSH2_k127_6765870_0	648996.Theam_0511	4.904e-76	262.0	COG2804@1|root,COG2804@2|Bacteria,2G3UR@200783|Aquificae	200783|Aquificae	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
WLSH2_k127_6765870_3	370438.PTH_1145	0.0001278	45.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,2603V@186807|Peptococcaceae	186801|Clostridia	NU	General secretory system II, protein E domain protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
WLSH2_k127_6765870_2	265072.Mfla_2142	1.164e-24	111.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,2KKCS@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
WLSH2_k127_6777926_5	1121104.AQXH01000007_gene476	0.0001959	44.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4PKW4@976|Bacteroidetes	976|Bacteroidetes	M	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,YadA_head
WLSH2_k127_6777926_1	1382304.JNIL01000001_gene2685	1.221e-13	78.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,4HAKE@91061|Bacilli,2787Z@186823|Alicyclobacillaceae	91061|Bacilli	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,PG_binding_1,Peptidase_S41
WLSH2_k127_6777926_0	1511.CLOST_0351	2.486e-18	88.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,25QD4@186804|Peptostreptococcaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,PG_binding_1,Peptidase_S41
WLSH2_k127_6777926_4	596330.HMPREF0628_0612	7.238e-07	51.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,22G90@1570339|Peptoniphilaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
WLSH2_k127_6777926_3	397291.C804_04291	1.448e-09	60.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,27I74@186928|unclassified Lachnospiraceae	186801|Clostridia	M	tail specific protease	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
WLSH2_k127_6777926_2	264732.Moth_1552	2.225e-13	72.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,42F7Z@68295|Thermoanaerobacterales	186801|Clostridia	U	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
WLSH2_k127_6828744_1	1232429.CBLL010000052_gene1440	0.0004857	43.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,1W7IC@1268|Micrococcaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
WLSH2_k127_6828744_0	1121434.AULY01000011_gene1728	1.146e-64	227.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2M7R2@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
WLSH2_k127_6834539_0	644107.SL1157_2843	7.758e-26	113.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,4NB1N@97050|Ruegeria	28211|Alphaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
WLSH2_k127_6870566_0	1123501.KB902284_gene2245	8.109e-05	53.0	COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,HemolysinCabind
WLSH2_k127_6876388_0	1121333.JMLH01000078_gene2853	3.916e-05	48.0	COG1141@1|root,COG1141@2|Bacteria,1VKNJ@1239|Firmicutes,3VRZN@526524|Erysipelotrichia	526524|Erysipelotrichia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
WLSH2_k127_6890625_2	1449336.JQLO01000001_gene248	2.892e-06	55.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,4HAEP@91061|Bacilli,27G8Y@186828|Carnobacteriaceae	91061|Bacilli	E	Amino acid kinase family	lysC	GO:0000166,GO:0003674,GO:0003824,GO:0004072,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017076,GO:0019202,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU03790	AA_kinase,ACT,ACT_7
WLSH2_k127_6890625_3	638302.HMPREF0908_1323	4.389e-05	46.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,4H3EA@909932|Negativicutes	909932|Negativicutes	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
WLSH2_k127_6890625_1	1027273.GZ77_23665	2.244e-13	76.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,1RS6X@1236|Gammaproteobacteria,1XITG@135619|Oceanospirillales	135619|Oceanospirillales	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
WLSH2_k127_6890625_0	1121481.AUAS01000002_gene3235	1.026e-38	149.0	COG1846@1|root,COG1846@2|Bacteria,4NT8S@976|Bacteroidetes	976|Bacteroidetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
WLSH2_k127_689960_1	857290.HMPREF9156_01054	1.12e-15	78.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4CZ2I@85004|Bifidobacteriales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WLSH2_k127_689960_2	762968.HMPREF9441_02853	2.746e-08	56.0	COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,2FMGP@200643|Bacteroidia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WLSH2_k127_689960_0	517418.Ctha_0694	1.654e-59	208.0	COG0714@1|root,COG0714@2|Bacteria,1FDTI@1090|Chlorobi	1090|Chlorobi	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WLSH2_k127_689960_3	1112216.JH594425_gene2134	2.259e-05	49.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2TR0T@28211|Alphaproteobacteria,2K1NZ@204457|Sphingomonadales	204457|Sphingomonadales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WLSH2_k127_6900711_1	1195236.CTER_1565	3.135e-08	55.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,3WKFF@541000|Ruminococcaceae	186801|Clostridia	S	Phosphoribosyl transferase domain	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
WLSH2_k127_6900711_0	1415775.U729_1656	8.379e-11	67.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,36IPK@31979|Clostridiaceae	186801|Clostridia	S	ComF family	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
WLSH2_k127_6935104_2	1226325.HMPREF1548_04464	2.317e-06	53.0	COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,36GX1@31979|Clostridiaceae	186801|Clostridia	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
WLSH2_k127_6935104_1	1280390.CBQR020000160_gene4249	6.153e-40	158.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4H9NR@91061|Bacilli,26R39@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH2_k127_6935104_0	697284.ERIC2_c09060	1.592e-49	182.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4H9NR@91061|Bacilli,26R39@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH2_k127_6946153_0	479434.Sthe_1030	1.235e-60	218.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi,27Y0B@189775|Thermomicrobia	189775|Thermomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
WLSH2_k127_6946153_1	1125863.JAFN01000001_gene1821	1.688e-60	213.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WLSH2_k127_6946845_0	1444309.JAQG01000025_gene3769	6.047e-50	195.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,26SN1@186822|Paenibacillaceae	91061|Bacilli	M	Carboxypeptidase	pbpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.4.1.129,3.4.16.4	ko:K21464	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
WLSH2_k127_6975552_0	936155.HFELIS_16070	4.181e-29	117.0	2AICC@1|root,318TJ@2|Bacteria,1Q0XM@1224|Proteobacteria,431XH@68525|delta/epsilon subdivisions,2YSDI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_7033595_0	331678.Cphamn1_0984	6.764e-06	51.0	COG1825@1|root,COG1825@2|Bacteria,1FE1I@1090|Chlorobi	1090|Chlorobi	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
WLSH2_k127_7049370_1	1069080.KB913028_gene455	1.729e-16	88.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,4H3ZQ@909932|Negativicutes	909932|Negativicutes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
WLSH2_k127_7049370_0	1262915.BN574_01031	4.165e-25	109.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,4H4X8@909932|Negativicutes	909932|Negativicutes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
WLSH2_k127_7051575_1	469615.FGAG_00328	4.761e-48	175.0	COG0210@1|root,COG0210@2|Bacteria,378QF@32066|Fusobacteria	32066|Fusobacteria	L	K03657 DNA helicase II ATP-dependent DNA helicase PcrA	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
WLSH2_k127_7051575_0	935836.JAEL01000122_gene2004	2.008e-80	282.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,1ZCM9@1386|Bacillus	91061|Bacilli	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
WLSH2_k127_7061091_2	880073.Calab_0284	1.576e-06	51.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	HD_5,Rrf2
WLSH2_k127_7061091_1	1033806.HTIA_2295	1.96e-13	79.0	COG0500@1|root,arCOG04583@2157|Archaea,2XTVC@28890|Euryarchaeota,23ST5@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
WLSH2_k127_7061091_0	1123376.AUIU01000014_gene558	2.044e-27	116.0	COG0358@1|root,COG0358@2|Bacteria,3J0IN@40117|Nitrospirae	40117|Nitrospirae	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
WLSH2_k127_7105595_3	631362.Thi970DRAFT_00452	3.876e-08	55.0	COG0863@1|root,COG1743@1|root,COG0863@2|Bacteria,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,1RMB6@1236|Gammaproteobacteria,1WXFZ@135613|Chromatiales	135613|Chromatiales	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
WLSH2_k127_7105595_2	861452.HMPREF9093_01059	2.128e-23	100.0	COG0343@1|root,COG0343@2|Bacteria,378C1@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
WLSH2_k127_7105595_1	679937.Bcop_1431	2.108e-27	113.0	COG0343@1|root,COG0343@2|Bacteria,4NE15@976|Bacteroidetes,2FMUM@200643|Bacteroidia,4AN36@815|Bacteroidaceae	976|Bacteroidetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
WLSH2_k127_7105595_0	352165.HMPREF7215_0927	2.384e-55	199.0	COG0343@1|root,COG0343@2|Bacteria,3TA1P@508458|Synergistetes	508458|Synergistetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
WLSH2_k127_714146_4	926550.CLDAP_12320	1.156e-12	71.0	COG1937@1|root,COG1937@2|Bacteria,2G7H9@200795|Chloroflexi	200795|Chloroflexi	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
WLSH2_k127_714146_7	909663.KI867150_gene4	2.536e-08	60.0	COG3462@1|root,COG3462@2|Bacteria,1Q55M@1224|Proteobacteria,42WZ8@68525|delta/epsilon subdivisions,2WSP8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
WLSH2_k127_714146_1	1304865.JAGF01000001_gene2536	4.859e-32	134.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,2IETB@201174|Actinobacteria	201174|Actinobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
WLSH2_k127_714146_3	1304865.JAGF01000001_gene2536	3.298e-21	99.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,2IETB@201174|Actinobacteria	201174|Actinobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
WLSH2_k127_714146_5	290402.Cbei_1435	1.299e-12	70.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,36DCI@31979|Clostridiaceae	186801|Clostridia	P	Heavy metal transport detoxification protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
WLSH2_k127_714146_0	935948.KE386495_gene1019	1.033e-66	237.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH2_k127_714146_6	338966.Ppro_2900	7.438e-09	57.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,43T86@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Heavy-metal-associated domain	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH2_k127_714146_2	159087.Daro_1051	4.478e-24	102.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,2KU93@206389|Rhodocyclales	206389|Rhodocyclales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH2_k127_715716_1	1267535.KB906767_gene3899	4.351e-38	149.0	COG0064@1|root,COG0064@2|Bacteria,3Y2TJ@57723|Acidobacteria,2JI20@204432|Acidobacteriia	204432|Acidobacteriia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
WLSH2_k127_715716_0	1476973.JMMB01000007_gene1090	1.488e-40	160.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,25QPV@186804|Peptostreptococcaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
WLSH2_k127_7164233_0	439235.Dalk_1419	1.365e-67	238.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2MJIB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WLSH2_k127_716699_0	289377.HL41_03560	4.628e-158	514.0	COG0542@1|root,COG0542@2|Bacteria,2GGRY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
WLSH2_k127_716699_1	309801.trd_0443	9.047e-94	311.0	COG0542@1|root,COG0542@2|Bacteria,2G5QU@200795|Chloroflexi,27XEJ@189775|Thermomicrobia	189775|Thermomicrobia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
WLSH2_k127_7183990_0	498211.CJA_1396	0.0001112	53.0	COG4254@1|root,COG4932@1|root,COG4254@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T4AQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
WLSH2_k127_7223170_0	926561.KB900623_gene1084	2.473e-69	248.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,3WAGQ@53433|Halanaerobiales	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
WLSH2_k127_7223170_2	1007096.BAGW01000006_gene1863	2.29e-09	65.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,2N77Z@216572|Oscillospiraceae	186801|Clostridia	J	Ribosomal protein L9, N-terminal domain	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
WLSH2_k127_7223170_1	944480.ATUV01000002_gene277	1.524e-16	84.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,42UC6@68525|delta/epsilon subdivisions,2WPDD@28221|Deltaproteobacteria,2M79G@213113|Desulfurellales	28221|Deltaproteobacteria	L	Likely ribonuclease with RNase H fold.	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
WLSH2_k127_7223170_3	1449345.JHWC01000008_gene1759	2.234e-07	52.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2YNEP@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
WLSH2_k127_7250604_0	187272.Mlg_0715	1.035e-79	276.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
WLSH2_k127_7250604_1	1380370.JIBA01000016_gene675	0.000838	46.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4FEYY@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH2_k127_7265819_0	1047013.AQSP01000118_gene1252	7.222e-79	276.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_7265819_1	1463926.JOCA01000008_gene2446	4.824e-05	51.0	COG0433@1|root,COG0433@2|Bacteria,2H4H2@201174|Actinobacteria	201174|Actinobacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,TraG-D_C,TrwB_AAD_bind
WLSH2_k127_733699_2	1175306.GWL_44920	6.331e-16	82.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,472M3@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
WLSH2_k127_733699_3	936574.HMPREF1508_0458	6.531e-07	55.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
WLSH2_k127_733699_0	1444309.JAQG01000038_gene2820	9.757e-150	485.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,4HA22@91061|Bacilli,26TFI@186822|Paenibacillaceae	91061|Bacilli	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
WLSH2_k127_733699_1	1316936.K678_13066	7.46e-37	141.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2JR68@204441|Rhodospirillales	204441|Rhodospirillales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
WLSH2_k127_7445588_0	862908.BMS_1902	1.736e-25	114.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2MSSX@213481|Bdellovibrionales,2WJ7V@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
WLSH2_k127_7445588_1	883067.HMPREF9237_00042	3.383e-05	49.0	COG2885@1|root,COG3064@1|root,COG2885@2|Bacteria,COG3064@2|Bacteria,2IC22@201174|Actinobacteria,4D3XJ@85005|Actinomycetales	201174|Actinobacteria	M	tail sheath protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	He_PIG,Rib,TSP_3
WLSH2_k127_7445588_2	796940.HMPREF9628_00842	0.0008891	50.0	COG4099@1|root,COG4886@1|root,COG5386@1|root,COG5520@1|root,COG4099@2|Bacteria,COG4886@2|Bacteria,COG5386@2|Bacteria,COG5520@2|Bacteria,1V266@1239|Firmicutes,24GXP@186801|Clostridia,25T8R@186804|Peptostreptococcaceae	186801|Clostridia	M	Leucine Rich Repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,DUF1533,LRR_8,NEAT,SLH
WLSH2_k127_7501957_0	595537.Varpa_0977	1.221e-14	76.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,4AAXV@80864|Comamonadaceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
WLSH2_k127_7503655_1	1123489.AUAN01000005_gene1559	1.094e-12	68.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,4H3CY@909932|Negativicutes	909932|Negativicutes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
WLSH2_k127_7503655_2	1121935.AQXX01000126_gene932	1.282e-11	70.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RSHC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid,zf-TFIIB
WLSH2_k127_7503655_0	413404.Rmag_0617	2.862e-39	151.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1J8M9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
WLSH2_k127_7511205_2	1123503.KB908057_gene2418	1.554e-05	50.0	COG0747@1|root,COG3468@1|root,COG5184@1|root,COG0747@2|Bacteria,COG3468@2|Bacteria,COG5184@2|Bacteria,1QUZ3@1224|Proteobacteria,2TZMX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MU	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter
WLSH2_k127_7511205_1	153948.NAL212_0720	2.838e-10	66.0	2E2YT@1|root,32XZH@2|Bacteria,1MYTS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_7511205_0	1078085.HMPREF1210_00088	3.564e-14	78.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,DUF3494,Glug,TIG
WLSH2_k127_7514919_1	1118059.CAHC01000012_gene385	0.0002926	46.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WCIW@538999|Clostridiales incertae sedis	186801|Clostridia	S	DHH family	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WLSH2_k127_7514919_0	909663.KI867150_gene1761	6.505e-25	111.0	COG0618@1|root,COG0618@2|Bacteria,1RAUQ@1224|Proteobacteria,42RKG@68525|delta/epsilon subdivisions,2WN0X@28221|Deltaproteobacteria,2MQDA@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	DHH family	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WLSH2_k127_7518913_2	1121115.AXVN01000017_gene240	2.597e-05	51.0	COG4968@1|root,COG4968@2|Bacteria,1VD7G@1239|Firmicutes,25FI2@186801|Clostridia,3Y0V4@572511|Blautia	186801|Clostridia	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
WLSH2_k127_7518913_1	362976.HQ_1961A	6.751e-09	61.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,23U2V@183963|Halobacteria	183963|Halobacteria	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
WLSH2_k127_7518913_0	314723.BH0059	2.991e-16	83.0	COG1253@1|root,COG1253@2|Bacteria,2J61P@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1253 Hemolysins and related protein containing CBS domains	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
WLSH2_k127_752975_0	1123248.KB893322_gene617	8.561e-31	132.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,4NIIR@976|Bacteroidetes,1IPF7@117747|Sphingobacteriia	976|Bacteroidetes	L	Belongs to the helicase family. UvrD subfamily	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
WLSH2_k127_752975_1	925409.KI911562_gene466	1.627e-23	106.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,4NIIR@976|Bacteroidetes,1IPF7@117747|Sphingobacteriia	976|Bacteroidetes	L	Belongs to the helicase family. UvrD subfamily	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
WLSH2_k127_752975_2	1120951.AUBG01000015_gene3405	9.989e-08	53.0	COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1HWS4@117743|Flavobacteriia	976|Bacteroidetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
WLSH2_k127_7568837_1	203119.Cthe_1345	1.1e-39	150.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,3WJCT@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
WLSH2_k127_7568837_2	1196322.A370_00680	2.208e-19	87.0	COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia,36I3G@31979|Clostridiaceae	186801|Clostridia	H	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)	luxS	-	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000	-	-	-	LuxS
WLSH2_k127_7568837_0	1294142.CINTURNW_3339	7.086e-56	197.0	COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia,36I3G@31979|Clostridiaceae	186801|Clostridia	H	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)	luxS	-	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000	-	-	-	LuxS
WLSH2_k127_7568837_4	1123278.KB893605_gene1751	3.612e-07	55.0	COG0775@1|root,COG0775@2|Bacteria,4NMPF@976|Bacteroidetes,47K2M@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
WLSH2_k127_7568837_3	1196083.SALWKB12_1840	4.773e-08	59.0	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,2VQBX@28216|Betaproteobacteria,2KQXN@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
WLSH2_k127_7611775_0	1131269.AQVV01000001_gene1416	0.0001887	52.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
WLSH2_k127_7622988_1	36875.HQ29_04765	2.664e-11	64.0	COG0324@1|root,COG0324@2|Bacteria,4NEAE@976|Bacteroidetes,2FNES@200643|Bacteroidia,22WDD@171551|Porphyromonadaceae	976|Bacteroidetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
WLSH2_k127_7622988_0	642492.Clole_3501	1.878e-11	73.0	COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia	186801|Clostridia	M	Polysaccharide pyruvyl transferase	csaB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans
WLSH2_k127_7646088_1	656519.Halsa_1601	1.294e-75	269.0	COG0849@1|root,COG0849@2|Bacteria,1TP1Z@1239|Firmicutes,24948@186801|Clostridia,3WA9N@53433|Halanaerobiales	186801|Clostridia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
WLSH2_k127_7646088_0	1460634.JCM19037_2418	3.811e-132	433.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,4H9WZ@91061|Bacilli	91061|Bacilli	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030428,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
WLSH2_k127_7653636_0	509191.AEDB02000048_gene4641	2.117e-69	257.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,3WIWG@541000|Ruminococcaceae	186801|Clostridia	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel,Cu_amine_oxidN1
WLSH2_k127_7675907_0	592031.GCWU000322_00869	0.0004734	47.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,25VJS@186806|Eubacteriaceae	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
WLSH2_k127_7730526_0	1033737.CAEV01000010_gene2448	4.605e-09	60.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,36E84@31979|Clostridiaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
WLSH2_k127_7739299_0	1313421.JHBV01000041_gene3530	5.678e-07	57.0	COG4642@1|root,COG4642@2|Bacteria	2|Bacteria	S	regulation of ryanodine-sensitive calcium-release channel activity	-	-	-	-	-	-	-	-	-	-	-	-	MORN
WLSH2_k127_7753247_0	393595.ABO_2523	0.0001356	48.0	COG0845@1|root,COG0845@2|Bacteria,1R866@1224|Proteobacteria,1SYE2@1236|Gammaproteobacteria,1XR97@135619|Oceanospirillales	135619|Oceanospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18302	-	M00642	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,8.A.1	-	-	HlyD_D23
WLSH2_k127_7761954_0	1296415.JACC01000023_gene4307	3.901e-05	51.0	COG0438@1|root,COG0438@2|Bacteria,4NETA@976|Bacteroidetes,1HZ9Z@117743|Flavobacteriia,2YHJW@290174|Aquimarina	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH2_k127_7787158_1	272562.CA_C3715	1.295e-76	267.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,36DTR@31979|Clostridiaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
WLSH2_k127_7787158_2	393480.FNP_1252	1.578e-05	56.0	COG0457@1|root,COG4282@1|root,COG0457@2|Bacteria,COG4282@2|Bacteria,37B6Y@32066|Fusobacteria	32066|Fusobacteria	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_8
WLSH2_k127_7787158_0	1121022.ABENE_14370	2.944e-189	605.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2KFR3@204458|Caulobacterales	204458|Caulobacterales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
WLSH2_k127_7787158_3	1429851.X548_16885	7.828e-05	46.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1X7IA@135614|Xanthomonadales	135614|Xanthomonadales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
WLSH2_k127_7917870_8	357808.RoseRS_2870	0.0002559	44.0	COG2373@1|root,COG2373@2|Bacteria,2G5XN@200795|Chloroflexi,37651@32061|Chloroflexia	32061|Chloroflexia	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5
WLSH2_k127_7917870_1	1121267.JHZL01000007_gene754	6.748e-35	140.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2YNWA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0321	Guanylate_kin
WLSH2_k127_7917870_4	1384484.AEQU_1319	1.863e-18	87.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4CUMS@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
WLSH2_k127_7917870_3	795359.TOPB45_0844	8.594e-19	89.0	COG0766@1|root,COG0766@2|Bacteria,2GHFF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
WLSH2_k127_7917870_0	742823.HMPREF9465_00785	2.195e-40	157.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,4PQJC@995019|Sutterellaceae	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
WLSH2_k127_7917870_2	626522.GCWU000325_00301	1.059e-28	122.0	COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,2FNSY@200643|Bacteroidia,1WD7E@1283313|Alloprevotella	976|Bacteroidetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WLSH2_k127_7917870_6	759914.BP951000_1387	1.03e-11	69.0	COG2304@1|root,COG2304@2|Bacteria,2J5I2@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,TPR_2,VWA
WLSH2_k127_7917870_7	926562.Oweho_2622	2.356e-07	53.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,1HWY3@117743|Flavobacteriia,2PARY@246874|Cryomorphaceae	976|Bacteroidetes	S	PFAM von Willebrand factor type A domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
WLSH2_k127_7917870_5	1410613.JNKF01000014_gene2067	3.59e-13	71.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,2FNXM@200643|Bacteroidia	976|Bacteroidetes	S	Von Willebrand factor type A domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
WLSH2_k127_7930176_0	641107.CDLVIII_3088	2.065e-29	120.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,24870@186801|Clostridia,36EMM@31979|Clostridiaceae	186801|Clostridia	M	sugar transferase	cpsE	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
WLSH2_k127_793605_0	517418.Ctha_0161	1.499e-120	392.0	COG0069@1|root,COG1773@1|root,COG0069@2|Bacteria,COG1773@2|Bacteria,1FDGS@1090|Chlorobi	1090|Chlorobi	C	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,Rubredoxin
WLSH2_k127_793605_1	517418.Ctha_0161	3.981e-56	201.0	COG0069@1|root,COG1773@1|root,COG0069@2|Bacteria,COG1773@2|Bacteria,1FDGS@1090|Chlorobi	1090|Chlorobi	C	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,Rubredoxin
WLSH2_k127_7960360_0	1123263.AUKY01000043_gene403	2.923e-50	194.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,3VNWA@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,RNR_N,Ribonuc_red_lgC,Ribonuc_red_lgN
WLSH2_k127_79738_0	224324.aq_797	3.688e-60	220.0	COG0793@1|root,COG0793@2|Bacteria,2G3RT@200783|Aquificae	200783|Aquificae	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
WLSH2_k127_79738_2	1121472.AQWN01000004_gene773	0.0001124	47.0	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia,262H5@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM desulfoferrodoxin FeS4 iron-binding domain	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
WLSH2_k127_79738_1	1235797.C816_02231	6.677e-07	52.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,2N71Y@216572|Oscillospiraceae	186801|Clostridia	I	Rubredoxin	bcd2	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
WLSH2_k127_7986355_0	296587.XP_002504075.1	4.675e-06	49.0	2D47E@1|root,2SU67@2759|Eukaryota,389V8@33090|Viridiplantae,34PF7@3041|Chlorophyta	296587.XP_002504075.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_8016581_4	1506583.JQJY01000001_gene431	5.858e-18	83.0	COG3967@1|root,COG3967@2|Bacteria,4NMPW@976|Bacteroidetes,1I7IH@117743|Flavobacteriia,2NTGD@237|Flavobacterium	976|Bacteroidetes	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
WLSH2_k127_8016581_0	1202532.FF52_08704	6.381e-65	226.0	COG3967@1|root,COG3967@2|Bacteria,4NMPW@976|Bacteroidetes,1I7IH@117743|Flavobacteriia,2NTGD@237|Flavobacterium	976|Bacteroidetes	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
WLSH2_k127_8016581_2	509635.N824_29570	5.089e-56	198.0	COG1733@1|root,COG1733@2|Bacteria,4NSVE@976|Bacteroidetes,1IYH6@117747|Sphingobacteriia	976|Bacteroidetes	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
WLSH2_k127_8016581_1	765420.OSCT_0738	1.552e-64	243.0	COG0847@1|root,COG1199@1|root,COG0847@2|Bacteria,COG1199@2|Bacteria,2G5P4@200795|Chloroflexi,374UA@32061|Chloroflexia	32061|Chloroflexia	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD_2,Helicase_C_2,RNase_T
WLSH2_k127_8016581_3	765420.OSCT_0738	3.055e-55	203.0	COG0847@1|root,COG1199@1|root,COG0847@2|Bacteria,COG1199@2|Bacteria,2G5P4@200795|Chloroflexi,374UA@32061|Chloroflexia	32061|Chloroflexia	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD_2,Helicase_C_2,RNase_T
WLSH2_k127_8020801_3	309803.CTN_1794	0.0002209	47.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH2_k127_8020801_1	1206739.BAGJ01000268_gene39	5.242e-10	71.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4FU95@85025|Nocardiaceae	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
WLSH2_k127_8020801_0	572478.Vdis_1542	3.889e-14	81.0	COG0500@1|root,arCOG01401@2157|Archaea,2XR2B@28889|Crenarchaeota	28889|Crenarchaeota	Q	TIGRFAM methyltransferase FkbM family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
WLSH2_k127_8020801_2	457405.FSDG_01122	0.0001753	53.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
WLSH2_k127_8031296_0	357809.Cphy_2574	5.537e-110	368.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,21XUT@1506553|Lachnoclostridium	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	-	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
WLSH2_k127_8093572_2	1408436.JHXY01000011_gene1509	2.551e-18	85.0	COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,25UTR@186806|Eubacteriaceae	186801|Clostridia	S	'oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,NAD_binding_8,Pyr_redox_2
WLSH2_k127_8093572_0	868595.Desca_0931	1.149e-99	331.0	COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,26146@186807|Peptococcaceae	186801|Clostridia	S	PFAM FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,NAD_binding_8,Pyr_redox_2
WLSH2_k127_8093572_1	428125.CLOLEP_02582	5.607e-22	96.0	COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,3WGFA@541000|Ruminococcaceae	186801|Clostridia	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,NAD_binding_8,Pyr_redox_2
WLSH2_k127_8115192_0	224324.aq_461	9.301e-97	325.0	COG0064@1|root,COG0064@2|Bacteria,2G3P7@200783|Aquificae	200783|Aquificae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
WLSH2_k127_8156131_0	293826.Amet_3229	2.754e-11	63.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
WLSH2_k127_8156131_1	288705.RSal33209_2445	2.57e-06	50.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,1W871@1268|Micrococcaceae	201174|Actinobacteria	C	Malate dehydrogenase	mez_1	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
WLSH2_k127_8156131_2	401526.TcarDRAFT_1293	1.716e-05	49.0	COG0503@1|root,COG0741@1|root,COG0503@2|Bacteria,COG0741@2|Bacteria,1TSYQ@1239|Firmicutes,4H5A6@909932|Negativicutes	909932|Negativicutes	F	protein secretion by the type IV secretion system	-	-	-	-	-	-	-	-	-	-	-	-	SLT
WLSH2_k127_8221480_0	535289.Dtpsy_0562	1.19e-24	112.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2VV87@28216|Betaproteobacteria,4AFMD@80864|Comamonadaceae	28216|Betaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_trans_1_4,Glycos_transf_2
WLSH2_k127_8282702_1	1410666.JHXG01000003_gene1237	2.363e-30	123.0	COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,2FMWR@200643|Bacteroidia	976|Bacteroidetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
WLSH2_k127_8282702_0	1089553.Tph_c25930	0.0	1127.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,42ETP@68295|Thermoanaerobacterales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WLSH2_k127_8312562_0	1046714.AMRX01000003_gene341	5.058e-11	66.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,46577@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006412,GO:0006518,GO:0006629,GO:0006644,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0010467,GO:0015949,GO:0015950,GO:0015951,GO:0016070,GO:0016208,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iECH74115_1262.ECH74115_0566,iEKO11_1354.EKO11_3373,iG2583_1286.G2583_0586,iJN746.PP_1506	ADK,ADK_lid
WLSH2_k127_8359923_5	1128421.JAGA01000002_gene700	5.911e-25	105.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WLSH2_k127_8359923_3	344747.PM8797T_12218	3.93e-32	126.0	COG0185@1|root,COG0185@2|Bacteria,2J0BB@203682|Planctomycetes	203682|Planctomycetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
WLSH2_k127_8359923_7	1469245.JFBG01000007_gene717	3.41e-18	88.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1WYH7@135613|Chromatiales	135613|Chromatiales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
WLSH2_k127_8359923_0	1283300.ATXB01000001_gene618	7.097e-55	199.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1XEGS@135618|Methylococcales	135618|Methylococcales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
WLSH2_k127_8359923_8	929562.Emtol_0508	4.315e-17	81.0	COG0197@1|root,COG0197@2|Bacteria,4NM87@976|Bacteroidetes,47P74@768503|Cytophagia	976|Bacteroidetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
WLSH2_k127_8359923_6	316274.Haur_4923	1.221e-18	87.0	COG0186@1|root,COG0186@2|Bacteria,2G722@200795|Chloroflexi,375WC@32061|Chloroflexia	32061|Chloroflexia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
WLSH2_k127_8359923_1	1408323.JQKK01000014_gene105	2.174e-47	172.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,27MQ8@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
WLSH2_k127_8359923_4	867902.Ornrh_0463	1.474e-26	113.0	COG0198@1|root,COG0198@2|Bacteria,4NSTI@976|Bacteroidetes,1I2VR@117743|Flavobacteriia	976|Bacteroidetes	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
WLSH2_k127_8359923_2	1304284.L21TH_0904	5.319e-40	152.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,36ENP@31979|Clostridiaceae	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
WLSH2_k127_8373963_0	644281.MFS40622_0402	3.488e-19	101.0	COG0859@1|root,arCOG09624@2157|Archaea	2157|Archaea	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	-
WLSH2_k127_8379327_0	1121459.AQXE01000001_gene2886	7.391e-58	205.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2M9TD@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WLSH2_k127_8379327_2	459495.SPLC1_S203600	4.926e-14	74.0	COG2173@1|root,COG2173@2|Bacteria,1G07K@1117|Cyanobacteria,1H8T7@1150|Oscillatoriales	1117|Cyanobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
WLSH2_k127_8379327_1	13035.Dacsa_3452	1.705e-18	88.0	COG2173@1|root,COG2173@2|Bacteria,1G07K@1117|Cyanobacteria	1117|Cyanobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
WLSH2_k127_8436579_0	1293054.HSACCH_00917	7.142e-82	278.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3WAE9@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WLSH2_k127_8436579_3	1184267.A11Q_1589	0.0001727	45.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2MU8J@213481|Bdellovibrionales,2WIVS@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
WLSH2_k127_8436579_1	1121335.Clst_2461	1.793e-08	58.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,3WGZ7@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
WLSH2_k127_8436579_2	292459.STH2540	7.308e-06	50.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
WLSH2_k127_8437193_1	1034943.BN1094_02363	7.693e-12	76.0	COG3868@1|root,COG3868@2|Bacteria,1MXYK@1224|Proteobacteria,1RMK1@1236|Gammaproteobacteria,1JFSD@118969|Legionellales	118969|Legionellales	S	Glycoside-hydrolase family GH114	-	-	-	ko:K21006	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_114
WLSH2_k127_8437193_0	521719.ATXQ01000002_gene2517	1.819e-19	89.0	COG4628@1|root,COG4628@2|Bacteria,1N7DG@1224|Proteobacteria,1SCBE@1236|Gammaproteobacteria,1YH22@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	DNA-binding protein VF530	-	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	VF530
WLSH2_k127_8437193_3	717772.THIAE_01585	0.0002445	46.0	28M4C@1|root,2ZAIA@2|Bacteria,1R67D@1224|Proteobacteria,1RQQQ@1236|Gammaproteobacteria,460BT@72273|Thiotrichales	72273|Thiotrichales	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
WLSH2_k127_8437193_2	1289135.A966_12351	3.08e-07	53.0	COG4637@1|root,COG4637@2|Bacteria,2J970@203691|Spirochaetes	203691|Spirochaetes	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
WLSH2_k127_8457560_2	574375.BAGA_22745	4.14e-10	61.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,4HEJ8@91061|Bacilli,1ZFPI@1386|Bacillus	91061|Bacilli	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
WLSH2_k127_8457560_1	857293.CAAU_0945	4.194e-36	153.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36EQ3@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
WLSH2_k127_8457560_0	1536775.H70737_21215	2.437e-66	238.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,26RZ6@186822|Paenibacillaceae	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
WLSH2_k127_847959_0	1120985.AUMI01000008_gene2737	1.609e-42	162.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,4H2UX@909932|Negativicutes	909932|Negativicutes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
WLSH2_k127_8508166_1	5722.XP_001318041.1	3.692e-08	57.0	COG0666@1|root,KOG0504@2759|Eukaryota	2759|Eukaryota	I	protein ubiquitination	-	-	-	ko:K15502,ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,DUF3447
WLSH2_k127_8508166_2	5722.XP_001582263.1	5.945e-06	49.0	COG0666@1|root,KOG4177@2759|Eukaryota,KOG4412@2759|Eukaryota	2759|Eukaryota	L	proteasome regulatory particle assembly	-	-	-	ko:K15503,ko:K15504	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,DUF3447
WLSH2_k127_8508166_0	62928.azo3476	8.19e-31	123.0	COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,2VQ6H@28216|Betaproteobacteria,2KW2X@206389|Rhodocyclales	206389|Rhodocyclales	KT	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	PAS_3
WLSH2_k127_8562141_2	439235.Dalk_5036	2.514e-07	55.0	COG1896@1|root,COG1896@2|Bacteria,1R71H@1224|Proteobacteria,42NGN@68525|delta/epsilon subdivisions,2WKMF@28221|Deltaproteobacteria,2MJT4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
WLSH2_k127_8562141_0	232348.ADXL01000054_gene1751	8.217e-95	313.0	COG0221@1|root,COG0221@2|Bacteria,1GD12@1117|Cyanobacteria,1GZ4D@1129|Synechococcus	1117|Cyanobacteria	C	Inorganic pyrophosphatase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
WLSH2_k127_8562141_1	1234409.C683_0683	5.594e-73	257.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,4HBKY@91061|Bacilli,4AZAU@81852|Enterococcaceae	91061|Bacilli	L	Belongs to the methyltransferase superfamily	ypsC	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
WLSH2_k127_8562822_0	935840.JAEQ01000007_gene3975	3.541e-29	125.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2U0DX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH2_k127_8562822_1	926550.CLDAP_10380	3.363e-06	50.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
WLSH2_k127_8612203_0	243231.GSU0564	1.725e-58	212.0	COG2888@1|root,COG2888@2|Bacteria,1MZH3@1224|Proteobacteria,42VBG@68525|delta/epsilon subdivisions,2WTZB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_8612203_1	926569.ANT_19510	1.448e-14	84.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
WLSH2_k127_8626600_1	398512.JQKC01000021_gene3660	8.873e-25	118.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,3WHYT@541000|Ruminococcaceae	186801|Clostridia	U	Membrane protein insertase, YidC Oxa1 family	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
WLSH2_k127_8626600_2	1035196.HMPREF9998_01829	2.877e-12	68.0	293PP@1|root,2ZR5C@2|Bacteria,1VBW4@1239|Firmicutes,24NKJ@186801|Clostridia,25RAV@186804|Peptostreptococcaceae	186801|Clostridia	S	UPF0489 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0489
WLSH2_k127_8626600_0	1292035.H476_3271	5.057e-41	157.0	293PP@1|root,2ZR5C@2|Bacteria,1VBW4@1239|Firmicutes,24NKJ@186801|Clostridia,25RAV@186804|Peptostreptococcaceae	186801|Clostridia	S	UPF0489 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0489
WLSH2_k127_8637250_2	700598.Niako_4760	1.272e-05	57.0	COG3656@1|root,COG5492@1|root,COG3656@2|Bacteria,COG5492@2|Bacteria,4NY36@976|Bacteroidetes	976|Bacteroidetes	N	TIGRFAM Fibrobacter succinogenes major paralogous domain	-	-	-	-	-	-	-	-	-	-	-	-	Fib_succ_major
WLSH2_k127_8637250_3	1150474.JQJI01000011_gene103	5.834e-05	50.0	COG1896@1|root,COG1896@2|Bacteria,2GCV2@200918|Thermotogae	200918|Thermotogae	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_2,HD_3
WLSH2_k127_8637250_1	1150474.JQJI01000011_gene103	5.575e-24	110.0	COG1896@1|root,COG1896@2|Bacteria,2GCV2@200918|Thermotogae	200918|Thermotogae	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_2,HD_3
WLSH2_k127_8637250_0	31234.CRE27373	2.748e-27	116.0	COG1243@1|root,KOG2535@2759|Eukaryota,38CUP@33154|Opisthokonta,3BDGU@33208|Metazoa,3CT1Y@33213|Bilateria,40BJV@6231|Nematoda,1KV6S@119089|Chromadorea,40ZGA@6236|Rhabditida	33208|Metazoa	BK	Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation	ELP3	GO:0000003,GO:0000123,GO:0000902,GO:0000904,GO:0001764,GO:0001932,GO:0002097,GO:0002098,GO:0002119,GO:0002164,GO:0002165,GO:0002168,GO:0002376,GO:0002520,GO:0002926,GO:0003006,GO:0003008,GO:0003674,GO:0003824,GO:0004402,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006139,GO:0006325,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006464,GO:0006473,GO:0006475,GO:0006518,GO:0006725,GO:0006807,GO:0006928,GO:0006996,GO:0007010,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007292,GO:0007399,GO:0007409,GO:0007416,GO:0007417,GO:0007528,GO:0007610,GO:0007611,GO:0007612,GO:0007626,GO:0007635,GO:0008023,GO:0008033,GO:0008080,GO:0008150,GO:0008152,GO:0008306,GO:0008355,GO:0008607,GO:0009058,GO:0009059,GO:0009451,GO:0009653,GO:0009790,GO:0009791,GO:0009889,GO:0009987,GO:0009994,GO:0010467,GO:0010468,GO:0010484,GO:0010485,GO:0010556,GO:0010769,GO:0010975,GO:0016043,GO:0016070,GO:0016407,GO:0016410,GO:0016477,GO:0016569,GO:0016570,GO:0016573,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019207,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019887,GO:0019953,GO:0022008,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0030030,GO:0030097,GO:0030154,GO:0030182,GO:0030234,GO:0030334,GO:0030335,GO:0030431,GO:0030865,GO:0031175,GO:0031248,GO:0031323,GO:0031326,GO:0031344,GO:0031399,GO:0031974,GO:0031981,GO:0032101,GO:0032268,GO:0032501,GO:0032502,GO:0032504,GO:0032774,GO:0032879,GO:0032989,GO:0032990,GO:0032991,GO:0033588,GO:0034212,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0036211,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0040025,GO:0042048,GO:0042221,GO:0042325,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043543,GO:0043549,GO:0043603,GO:0043604,GO:0043966,GO:0043967,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0045202,GO:0045595,GO:0045664,GO:0045859,GO:0046483,GO:0048232,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048534,GO:0048569,GO:0048583,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048789,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050767,GO:0050770,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050808,GO:0050877,GO:0050890,GO:0050896,GO:0050920,GO:0051124,GO:0051128,GO:0051171,GO:0051174,GO:0051179,GO:0051239,GO:0051246,GO:0051252,GO:0051270,GO:0051272,GO:0051276,GO:0051338,GO:0051674,GO:0051704,GO:0051960,GO:0060255,GO:0060284,GO:0061564,GO:0061733,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097659,GO:0098772,GO:0120035,GO:0120036,GO:0120039,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902493,GO:1902494,GO:1902667,GO:1903506,GO:1990234,GO:2000026,GO:2000112,GO:2000145,GO:2000147,GO:2000289,GO:2001141	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
WLSH2_k127_866055_1	1343739.PAP_07460	0.0009364	50.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
WLSH2_k127_866055_0	926561.KB900623_gene1091	2.668e-159	522.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,3WAD8@53433|Halanaerobiales	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
WLSH2_k127_8663765_0	269798.CHU_2779	1.656e-28	126.0	COG3391@1|root,COG3391@2|Bacteria,4NNEF@976|Bacteroidetes,47PBP@768503|Cytophagia	976|Bacteroidetes	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,NHL
WLSH2_k127_8679935_1	1000569.HMPREF1040_0070	0.0003676	45.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H2T1@909932|Negativicutes	909932|Negativicutes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
WLSH2_k127_8679935_0	1284352.AOIG01000006_gene2685	7.922e-46	172.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H9U2@91061|Bacilli,26RFS@186822|Paenibacillaceae	91061|Bacilli	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
WLSH2_k127_876543_0	1006581.GCW_00030	7.504e-07	55.0	COG0230@1|root,COG0230@2|Bacteria,3WU02@544448|Tenericutes	544448|Tenericutes	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
WLSH2_k127_876543_1	1112274.KI911560_gene1093	7.783e-06	52.0	COG0594@1|root,COG0594@2|Bacteria,1PVTJ@1224|Proteobacteria,2VUPA@28216|Betaproteobacteria,2KN5U@206350|Nitrosomonadales	206350|Nitrosomonadales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
WLSH2_k127_876543_2	574087.Acear_1202	0.0003135	50.0	COG1075@1|root,COG1075@2|Bacteria,1VJP5@1239|Firmicutes,250IX@186801|Clostridia,3WBMR@53433|Halanaerobiales	186801|Clostridia	S	Putative serine esterase (DUF676)	-	-	-	-	-	-	-	-	-	-	-	-	DUF676
WLSH2_k127_8830228_0	1123073.KB899244_gene186	1.139e-06	57.0	COG1470@1|root,COG3209@1|root,COG5184@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG5184@2|Bacteria,1N55D@1224|Proteobacteria,1T481@1236|Gammaproteobacteria,1XD8U@135614|Xanthomonadales	135614|Xanthomonadales	DMZ	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG
WLSH2_k127_8830228_2	414684.RC1_1137	1.866e-06	52.0	COG5301@1|root,COG5301@2|Bacteria,1N59Q@1224|Proteobacteria,2UN28@28211|Alphaproteobacteria,2JWW2@204441|Rhodospirillales	204441|Rhodospirillales	G	cellulose 1,4-beta-cellobiosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_8830228_1	1304888.ATWF01000002_gene248	1.176e-06	56.0	COG4733@1|root,COG5301@1|root,COG4733@2|Bacteria,COG5301@2|Bacteria	2|Bacteria	G	cellulose 1,4-beta-cellobiosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,NPCBM,Phage-tail_3,Phage_fiber_2,fn3
WLSH2_k127_8830228_3	309799.DICTH_0726	2.116e-05	50.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	Lectin_C,N_methyl,SBP_bac_10,T2SSG
WLSH2_k127_8850790_0	640081.Dsui_3078	3.137e-118	393.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VNJW@28216|Betaproteobacteria,2KW08@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
WLSH2_k127_8850790_2	82654.Pse7367_1168	2.055e-07	54.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1G107@1117|Cyanobacteria,1H9NE@1150|Oscillatoriales	1117|Cyanobacteria	T	CHASE2 domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WLSH2_k127_8850790_1	1410609.JHVB01000001_gene1992	6.976e-17	83.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
WLSH2_k127_8873031_6	635013.TherJR_1924	5.767e-08	57.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,26071@186807|Peptococcaceae	186801|Clostridia	J	tRNA synthetase class II core domain (G, H, P, S and T)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
WLSH2_k127_8873031_0	1336241.JAEB01000001_gene140	4.25e-212	667.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,25UUG@186806|Eubacteriaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
WLSH2_k127_8873031_5	765420.OSCT_1155	3.637e-11	69.0	COG0355@1|root,COG0355@2|Bacteria,2G70H@200795|Chloroflexi,375QG@32061|Chloroflexia	32061|Chloroflexia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
WLSH2_k127_8873031_3	469618.FVAG_01929	3.065e-23	106.0	COG4122@1|root,COG4122@2|Bacteria,379F0@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
WLSH2_k127_8873031_2	1353529.M899_0022	6.89e-28	121.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2MSM0@213481|Bdellovibrionales,2WIVR@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
WLSH2_k127_8873031_1	351627.Csac_1206	4.587e-52	188.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,42EQJ@68295|Thermoanaerobacterales	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
WLSH2_k127_8873031_4	1123389.ATXJ01000017_gene48	9.509e-21	93.0	COG1197@1|root,COG1197@2|Bacteria,1WIRU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
WLSH2_k127_8887974_0	383372.Rcas_1996	6.564e-16	87.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,375FQ@32061|Chloroflexia	32061|Chloroflexia	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
WLSH2_k127_8887974_2	1463845.JOIG01000006_gene1038	9.868e-07	53.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria	201174|Actinobacteria	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
WLSH2_k127_8887974_1	485913.Krac_10581	8.194e-10	63.0	COG1316@1|root,COG1316@2|Bacteria	2|Bacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
WLSH2_k127_8922644_1	883114.HMPREF9709_01011	2.308e-07	58.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,22G1U@1570339|Peptoniphilaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
WLSH2_k127_8922644_0	596151.DesfrDRAFT_1797	3.821e-17	83.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2M8QF@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
WLSH2_k127_8924423_0	1122609.AUGT01000010_gene3709	8.423e-05	52.0	COG2304@1|root,COG2304@2|Bacteria,2I5F3@201174|Actinobacteria	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cutinase,PKD
WLSH2_k127_8974626_0	446470.Snas_5142	2.234e-07	52.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4EY90@85014|Glycomycetales	201174|Actinobacteria	O	PDZ domain (Also known as DHR or GLGF)	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
WLSH2_k127_8974626_1	13035.Dacsa_2159	3.284e-05	48.0	COG0265@1|root,COG0265@2|Bacteria,1G17C@1117|Cyanobacteria	1117|Cyanobacteria	O	typically periplasmic contain C-terminal PDZ domain	hhoA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WLSH2_k127_8974626_2	1191523.MROS_0955	0.0001164	46.0	COG1986@1|root,COG1986@2|Bacteria	2|Bacteria	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	iECO111_1330.ECO111_5255	NTPase_I-T
WLSH2_k127_8988148_1	639030.JHVA01000001_gene1258	2.419e-12	68.0	COG0223@1|root,COG0223@2|Bacteria,3Y32C@57723|Acidobacteria,2JHUK@204432|Acidobacteriia	204432|Acidobacteriia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
WLSH2_k127_8988148_0	351627.Csac_2081	3.887e-38	146.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,42FC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
WLSH2_k127_8988148_2	515622.bpr_I1065	0.0002646	46.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,4BWRI@830|Butyrivibrio	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
WLSH2_k127_9022293_1	1122216.AUHW01000005_gene556	1.033e-29	123.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4H2H6@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH2_k127_9022293_0	159087.Daro_1168	7.729e-33	134.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria,2KZWY@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH2_k127_903032_0	1223545.GS4_08_00660	7.992e-39	147.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4GAY7@85026|Gordoniaceae	201174|Actinobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
WLSH2_k127_903032_1	517418.Ctha_2594	3.135e-06	57.0	COG0457@1|root,COG0457@2|Bacteria,1FFR7@1090|Chlorobi	1090|Chlorobi	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_9047202_0	1047013.AQSP01000123_gene1545	1.498e-20	105.0	COG2373@1|root,COG2373@2|Bacteria,2NQA2@2323|unclassified Bacteria	2|Bacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
WLSH2_k127_9047202_1	394221.Mmar10_0443	9.787e-05	45.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria,43Y2X@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Belongs to the pirin family	yhhW	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
WLSH2_k127_9048469_4	240292.Ava_4205	7.156e-08	57.0	COG0268@1|root,COG0268@2|Bacteria,1G7PV@1117|Cyanobacteria,1HSIA@1161|Nostocales	1117|Cyanobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
WLSH2_k127_9048469_2	591001.Acfer_0664	2.689e-17	87.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,4H3YT@909932|Negativicutes	909932|Negativicutes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
WLSH2_k127_9048469_3	556263.FSEG_00092	4.794e-12	68.0	COG0291@1|root,COG0291@2|Bacteria,37ANM@32066|Fusobacteria	32066|Fusobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
WLSH2_k127_9048469_0	1265502.KB905930_gene1550	7.85e-29	120.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,4ADXV@80864|Comamonadaceae	28216|Betaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
WLSH2_k127_9048469_1	1410638.JHXJ01000008_gene416	1.623e-19	91.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia,3WKGN@541000|Ruminococcaceae	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
WLSH2_k127_907221_0	331113.SNE_A05330	7.242e-153	491.0	COG0443@1|root,COG0443@2|Bacteria,2JFEI@204428|Chlamydiae	204428|Chlamydiae	O	Heat shock 70 kDa protein	dnaK	GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
WLSH2_k127_9100422_0	557598.LHK_01716	5.041e-41	153.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,2KPPV@206351|Neisseriales	206351|Neisseriales	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
WLSH2_k127_9100422_1	556268.OFAG_01300	2.277e-35	135.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,4739J@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1,3.1.11.6	ko:K03601,ko:K04564	ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Sod_Fe_C,Sod_Fe_N
WLSH2_k127_9100422_2	1121382.JQKG01000001_gene2317	9.913e-08	58.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	bdbD	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
WLSH2_k127_9136715_3	1121904.ARBP01000002_gene7166	3.723e-05	46.0	COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,47PUA@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WLSH2_k127_9136715_1	537971.HCCG_00844	3.767e-09	59.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2YNVV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	bacterioferritin comigratory protein	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WLSH2_k127_9136715_4	445970.ALIPUT_01992	0.0003061	43.0	COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,2FNJA@200643|Bacteroidia	976|Bacteroidetes	P	copper-exporting ATPase	actP	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH2_k127_9136715_0	857293.CAAU_0298	3.043e-51	186.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH2_k127_9136715_2	1463921.JODF01000045_gene6642	3.294e-08	55.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	cadA	-	3.6.3.3,3.6.3.4,3.6.3.5,3.6.3.54	ko:K01533,ko:K01534,ko:K17686,ko:K21887	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3,3.A.3.5,3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
WLSH2_k127_9183294_0	1239962.C943_04447	2.453e-17	95.0	COG5267@1|root,COG5267@2|Bacteria,4NHSB@976|Bacteroidetes,47MD4@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
WLSH2_k127_9229448_1	709991.Odosp_0764	1.99e-30	129.0	COG0847@1|root,COG0847@2|Bacteria,4NP7B@976|Bacteroidetes,2FSMF@200643|Bacteroidia,22Y26@171551|Porphyromonadaceae	976|Bacteroidetes	L	Exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
WLSH2_k127_9229448_0	1294142.CINTURNW_0968	6.22e-49	180.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,36E5A@31979|Clostridiaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
WLSH2_k127_9229448_2	4155.Migut.D01199.1.p	1.575e-22	101.0	COG0484@1|root,KOG0715@2759|Eukaryota,37M6Z@33090|Viridiplantae,3GBY2@35493|Streptophyta,44EJ4@71274|asterids	35493|Streptophyta	O	Chaperone protein DNAj	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
WLSH2_k127_9290924_1	469371.Tbis_1146	2.848e-26	111.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4DX6U@85010|Pseudonocardiales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
WLSH2_k127_9290924_0	457396.CSBG_00338	3.26e-44	165.0	COG3103@1|root,COG4991@2|Bacteria,1V4Q0@1239|Firmicutes,24G0J@186801|Clostridia,36I4A@31979|Clostridiaceae	186801|Clostridia	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF285
WLSH2_k127_9294360_0	443255.SCLAV_1332	3.359e-08	62.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,2GJ8N@201174|Actinobacteria	201174|Actinobacteria	EH	anthranilate synthase	phzE	-	2.6.1.86	ko:K13063	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	R08956	RC00010,RC02387	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind,GATase
WLSH2_k127_9294360_1	1122182.KB903823_gene1388	4.633e-05	46.0	COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,2GJ8N@201174|Actinobacteria,4DBN5@85008|Micromonosporales	201174|Actinobacteria	EH	chorismate binding enzyme	phzE	-	2.6.1.86	ko:K13063	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	R08956	RC00010,RC02387	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind,GATase
WLSH2_k127_9304632_0	340099.Teth39_0569	2.175e-127	416.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,42F1Y@68295|Thermoanaerobacterales	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
WLSH2_k127_9312521_0	1123020.AUIE01000007_gene3216	5.269e-09	61.0	COG3209@1|root,COG3209@2|Bacteria,1NF2V@1224|Proteobacteria	1224|Proteobacteria	M	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
WLSH2_k127_9312521_1	1227349.C170_12405	0.0001525	47.0	COG4099@1|root,COG5263@1|root,COG4099@2|Bacteria,COG5263@2|Bacteria,1VS9V@1239|Firmicutes,4HUV4@91061|Bacilli,26TZF@186822|Paenibacillaceae	91061|Bacilli	DZ	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,Peptidase_S9,SLH,fn3
WLSH2_k127_9326086_0	945713.IALB_3061	4.493e-23	102.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	MA20_16520	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
WLSH2_k127_9326086_3	290512.Paes_0204	0.0001834	50.0	COG1262@1|root,COG1680@1|root,COG1262@2|Bacteria,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,Fib_succ_major,TIR_2
WLSH2_k127_9326086_1	1097668.BYI23_C002750	3.447e-15	76.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VJ81@28216|Betaproteobacteria,1K5DI@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
WLSH2_k127_9326086_2	1382358.JHVN01000002_gene2339	2.097e-13	75.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,21W76@150247|Anoxybacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
WLSH2_k127_9337008_1	643867.Ftrac_0103	5.813e-22	99.0	2C6BU@1|root,32S87@2|Bacteria,4NRX1@976|Bacteroidetes,47R4G@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_9337008_2	1313293.BAN_0114400	0.0003525	44.0	COG0180@1|root,COG0180@2|Bacteria,2J68U@203691|Spirochaetes	203691|Spirochaetes	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
WLSH2_k127_9337008_0	439235.Dalk_5223	1.643e-28	118.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MJCB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
WLSH2_k127_9384732_0	1123054.KB907720_gene3231	8.793e-77	265.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
WLSH2_k127_9384732_1	397288.C806_01180	2.84e-27	114.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,27ISX@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
WLSH2_k127_9408068_2	1403819.BATR01000049_gene1416	5.945e-38	152.0	COG0224@1|root,COG0224@2|Bacteria,46SGU@74201|Verrucomicrobia,2ITXP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
WLSH2_k127_9408068_3	204773.HEAR3406	2.13e-07	53.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,472M2@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
WLSH2_k127_9408068_0	387092.NIS_1222	1.279e-161	515.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2YMSF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iIT341.HP1134	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
WLSH2_k127_9408068_1	1042876.PPS_5275	4.221e-38	147.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1YVWI@136845|Pseudomonas putida group	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iSbBS512_1146.SbBS512_E4187	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
WLSH2_k127_9436622_0	748449.Halha_1788	0.0003097	51.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	gspG	-	-	ko:K02456,ko:K02650,ko:K02655	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	ComP_DUS,N_methyl,T2SSG
WLSH2_k127_9442268_1	762984.HMPREF9445_00202	6.995e-08	64.0	COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes,2FN2G@200643|Bacteroidia,4AMKY@815|Bacteroidaceae	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
WLSH2_k127_9442268_0	742743.HMPREF9453_00693	7.222e-72	247.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4H22T@909932|Negativicutes	909932|Negativicutes	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH2_k127_9475918_0	557598.LHK_02220	1.933e-19	90.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2VIFF@28216|Betaproteobacteria,2KQ2S@206351|Neisseriales	206351|Neisseriales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WLSH2_k127_9548361_1	748449.Halha_0154	9.947e-11	63.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3WA8Y@53433|Halanaerobiales	186801|Clostridia	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
WLSH2_k127_9548361_2	573413.Spirs_0297	1.091e-05	48.0	COG0293@1|root,COG0293@2|Bacteria,2J5SK@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
WLSH2_k127_9548361_0	335543.Sfum_0997	7.335e-20	93.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,42T4F@68525|delta/epsilon subdivisions,2WP6B@28221|Deltaproteobacteria,2MQP6@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
WLSH2_k127_9558699_0	123214.PERMA_0951	1.846e-23	104.0	COG0642@1|root,COG2205@2|Bacteria	123214.PERMA_0951|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH2_k127_9567019_1	616991.JPOO01000001_gene3517	8.834e-07	50.0	COG0771@1|root,COG0771@2|Bacteria,4NEFF@976|Bacteroidetes,1HX80@117743|Flavobacteriia,23GUF@178469|Arenibacter	976|Bacteroidetes	M	Mur ligase family, glutamate ligase domain	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
WLSH2_k127_9567019_0	1313265.JNIE01000006_gene186	6.811e-26	115.0	COG0771@1|root,COG0771@2|Bacteria,2G3XE@200783|Aquificae	200783|Aquificae	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
WLSH2_k127_9589371_0	264199.stu1801	1.113e-52	196.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli	91061|Bacilli	L	Hydrolase, tatd	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WLSH2_k127_962310_2	398767.Glov_2914	2.823e-11	68.0	COG0028@1|root,COG1361@1|root,COG3386@1|root,COG3468@1|root,COG0028@2|Bacteria,COG1361@2|Bacteria,COG3386@2|Bacteria,COG3468@2|Bacteria,1QVSF@1224|Proteobacteria	1224|Proteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF11,DUF1566,Laminin_G_3,OmpA,OmpA_membrane,TIG
WLSH2_k127_962310_0	1229520.ADIAL_1015	2.546e-157	514.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,27F9T@186828|Carnobacteriaceae	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WLSH2_k127_962310_1	622312.ROSEINA2194_03012	1.316e-21	95.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WLSH2_k127_9629089_0	90814.KL370891_gene742	1.016e-23	106.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,45ZPQ@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
WLSH2_k127_9640765_1	759914.BP951000_2294	1.857e-05	51.0	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
WLSH2_k127_9640765_0	234267.Acid_2300	4.936e-17	93.0	COG2373@1|root,COG2373@2|Bacteria,3Y439@57723|Acidobacteria	57723|Acidobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
WLSH2_k127_9673671_0	347256.MHO_2610	7.834e-27	114.0	COG0335@1|root,COG0335@2|Bacteria,3WTJW@544448|Tenericutes	544448|Tenericutes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
WLSH2_k127_9673671_1	1007104.SUS17_1864	0.0008835	45.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U8VA@28211|Alphaproteobacteria,2K4TG@204457|Sphingomonadales	204457|Sphingomonadales	NU	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
WLSH2_k127_9692159_1	1042877.GQS_00060	2.437e-66	238.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,243FX@183968|Thermococci	183968|Thermococci	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
WLSH2_k127_9692159_0	525904.Tter_0997	3.583e-76	265.0	COG0391@1|root,COG0391@2|Bacteria,2NP7Q@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0052	ybhK	-	-	-	-	-	-	-	-	-	-	-	UPF0052
WLSH2_k127_9732163_0	632335.Calkr_1906	1.351e-316	1007.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,42FED@68295|Thermoanaerobacterales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
WLSH2_k127_9751325_1	1121267.JHZL01000001_gene678	4.039e-11	65.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2YMQJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
WLSH2_k127_9751325_0	667014.Thein_1826	8.902e-52	190.0	COG0053@1|root,COG0053@2|Bacteria,2GH3U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
WLSH2_k127_9756306_0	4096.XP_009788599.1	1.79e-08	59.0	COG0563@1|root,KOG3079@2759|Eukaryota,37RRS@33090|Viridiplantae,3GGWH@35493|Streptophyta,44PW9@71274|asterids	35493|Streptophyta	F	Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors	-	-	2.7.4.14	ko:K13800	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00052	R00158,R00512,R01665,R11891,R11892	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	ADK
WLSH2_k127_9782955_0	1229909.NSED_07010	0.0002238	52.0	COG3794@1|root,arCOG10350@1|root,arCOG02926@2157|Archaea,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Kazal_1
WLSH2_k127_9875333_0	1410658.JHWI01000011_gene1643	2.125e-45	174.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,3VP5F@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
WLSH2_k127_9875333_2	267377.MMP1541	0.0001226	49.0	COG4818@1|root,arCOG04344@2157|Archaea,2XZ6C@28890|Euryarchaeota,23R98@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
WLSH2_k127_9875333_1	1278311.AUAL01000031_gene1589	2.865e-29	121.0	COG0264@1|root,COG0264@2|Bacteria,3WT1W@544448|Tenericutes	544448|Tenericutes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
WLSH2_k127_9878616_0	391625.PPSIR1_25711	2.864e-17	83.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
WLSH2_k127_9878616_1	391625.PPSIR1_25711	3.847e-14	73.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
WLSH2_k127_9878616_2	391625.PPSIR1_25711	3.954e-09	59.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
WLSH2_k127_9883126_0	485913.Krac_8498	7.441e-19	96.0	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi	200795|Chloroflexi	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
WLSH2_k127_9900067_0	717772.THIAE_09715	6.034e-87	291.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales	72273|Thiotrichales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
WLSH2_k127_9900067_1	1453500.AT05_09315	3.195e-63	226.0	COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,1HX5E@117743|Flavobacteriia	976|Bacteroidetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
WLSH2_k127_9925585_2	857087.Metme_1830	2.246e-48	181.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1XGNR@135618|Methylococcales	135618|Methylococcales	P	PFAM Cation H exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
WLSH2_k127_9925585_0	1408322.JHYK01000017_gene1705	3.214e-66	235.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,27IHU@186928|unclassified Lachnospiraceae	186801|Clostridia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
WLSH2_k127_9925585_3	936375.HMPREF1152_0361	0.0001665	45.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
WLSH2_k127_9925585_1	1121289.JHVL01000035_gene2635	3.104e-56	203.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,36E8U@31979|Clostridiaceae	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
WLSH2_k127_9959602_0	561175.KB894093_gene3997	2.37e-10	72.0	COG3764@1|root,COG3764@2|Bacteria,2GNWT@201174|Actinobacteria	201174|Actinobacteria	M	Sortase (surface protein transpeptidase)	srtA	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
WLSH2_k127_9984710_3	592029.DDD_1881	4.287e-07	53.0	COG1943@1|root,COG1943@2|Bacteria,4NPWC@976|Bacteroidetes,1I28P@117743|Flavobacteriia	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
WLSH2_k127_9984710_5	945713.IALB_1198	0.0001527	46.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
WLSH2_k127_9984710_4	1536773.R70331_24930	7.16e-07	63.0	COG1621@1|root,COG1621@2|Bacteria,1UIIZ@1239|Firmicutes,4HT62@91061|Bacilli,26Q9S@186822|Paenibacillaceae	91061|Bacilli	G	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
WLSH2_k127_9984710_2	264731.PRU_0991	5.211e-14	74.0	COG0514@1|root,COG0514@2|Bacteria,4NG10@976|Bacteroidetes,2FPSQ@200643|Bacteroidia	976|Bacteroidetes	L	ATP-dependent DNA helicase	recQ3	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
WLSH2_k127_9984710_1	1304880.JAGB01000003_gene1153	1.602e-21	95.0	COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia	186801|Clostridia	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
WLSH2_k127_9984710_0	1396141.BATP01000022_gene456	5.974e-47	175.0	COG0514@1|root,COG0514@2|Bacteria,46U82@74201|Verrucomicrobia,2ITT4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	RQC	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
WLSH2_k127_9984710_6	1313301.AUGC01000001_gene1423	0.0004032	51.0	COG0514@1|root,COG0514@2|Bacteria,4NEFD@976|Bacteroidetes	976|Bacteroidetes	L	ATP-dependent DNA helicase RecQ	recQ2	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
WLSH2_k127_9991364_0	1506583.JQJY01000005_gene2344	1.851e-131	422.0	COG1209@1|root,COG1209@2|Bacteria,4NE1U@976|Bacteroidetes,1HWWH@117743|Flavobacteriia,2NS8M@237|Flavobacterium	976|Bacteroidetes	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WLSH2_k127_9994642_0	1123315.AUIP01000003_gene65	6.764e-56	201.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,4H9Z2@91061|Bacilli	91061|Bacilli	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
WLSH2_k127_9994642_1	426368.MmarC7_0341	2.988e-12	70.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVVS@28890|Euryarchaeota,23Q3M@183939|Methanococci	183939|Methanococci	S	Polysaccharide biosynthesis protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
## 834 queries scanned
## Total time (seconds): 46.435030698776245
## Rate: 17.96 q/s