## Tue Dec 16 23:00:34 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/WLSH3_bin.31.fa -m mmseqs --itype genome -o WLSH3_bin.31 --output_dir /data/result/bins/wyx/egg/WLSH3_bin.31 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
WLSH3_k127_10015623_0	1054217.TALC_01391	3.684e-77	275.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,242ID@183967|Thermoplasmata	2157|Archaea	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
WLSH3_k127_10038420_0	573413.Spirs_3146	2.494e-146	476.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WLSH3_k127_10045419_2	1122223.KB890698_gene968	3.164e-23	104.0	COG3118@1|root,COG3118@2|Bacteria,1WK9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH3_k127_10045419_0	48698.ENSPFOP00000011783	3.24e-52	198.0	COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,47ZN8@7711|Chordata,498TD@7742|Vertebrata,4A16Y@7898|Actinopterygii	33208|Metazoa	E	Si dkey-103j14.5	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
WLSH3_k127_10045419_1	404589.Anae109_2774	5.789e-32	127.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,42UGV@68525|delta/epsilon subdivisions,2WR1G@28221|Deltaproteobacteria,2YUDE@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_10063040_2	114615.BRADO7053	3.936e-08	61.0	COG0438@1|root,COG0438@2|Bacteria,1R4NX@1224|Proteobacteria,2U1EN@28211|Alphaproteobacteria,3JXK2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
WLSH3_k127_10063040_1	439481.Aboo_1481	2.746e-26	125.0	arCOG08157@1|root,arCOG08157@2157|Archaea,2Y70I@28890|Euryarchaeota,3F332@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10063040_0	342949.PNA2_1019	7.824e-74	261.0	COG1817@1|root,arCOG01395@2157|Archaea,2Y69N@28890|Euryarchaeota,243HY@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
WLSH3_k127_10063460_3	926560.KE387023_gene2369	2.547e-44	167.0	COG2050@1|root,COG2050@2|Bacteria,1WJVA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
WLSH3_k127_10063460_2	309799.DICTH_1588	6.589e-139	450.0	COG4952@1|root,COG4952@2|Bacteria	2|Bacteria	M	isomerase activity	xylA_2	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
WLSH3_k127_10063460_1	1499967.BAYZ01000057_gene4667	5.411e-188	601.0	COG1070@1|root,COG1070@2|Bacteria,2NQ9W@2323|unclassified Bacteria	2|Bacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	1.1.1.57,2.7.1.17	ko:K00040,ko:K00854,ko:K19168	ko00040,ko01100,map00040,map01100	M00014,M00061	R01639,R02454	RC00002,RC00085,RC00538	ko00000,ko00001,ko00002,ko01000,ko02048	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_10063460_0	1195236.CTER_3560	7.627e-210	672.0	COG1472@1|root,COG1472@2|Bacteria,1VSFU@1239|Firmicutes,25BFI@186801|Clostridia	186801|Clostridia	G	PFAM Glycosyl hydrolase family 3 C terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
WLSH3_k127_10063984_0	388399.SSE37_10218	1.033e-15	90.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,2TSRS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG1002 Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase,TaqI_C
WLSH3_k127_10121298_0	330084.JNYZ01000011_gene7403	2.251e-80	278.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_10121298_1	485913.Krac_4513	7.112e-06	48.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
WLSH3_k127_10138997_0	309799.DICTH_1532	1.157e-12	74.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_10172615_0	1150474.JQJI01000008_gene1328	2.885e-74	260.0	COG1085@1|root,COG1085@2|Bacteria,2GBX8@200918|Thermotogae	200918|Thermotogae	H	PFAM galactose-1-phosphate uridyl transferase domain protein	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
WLSH3_k127_10172615_1	926550.CLDAP_35280	4.23e-47	181.0	COG0454@1|root,COG0456@2|Bacteria,2G91C@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_10172615_2	1137268.AZXF01000010_gene2754	5.596e-11	66.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
WLSH3_k127_10176467_1	1042877.GQS_04860	7.812e-39	149.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,243D0@183968|Thermococci	183968|Thermococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
WLSH3_k127_10176467_0	523850.TON_0072	3.978e-53	197.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
WLSH3_k127_1019005_0	1303518.CCALI_00439	3.687e-101	341.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	MA20_31690	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_1019005_1	868131.MSWAN_0193	3.633e-31	131.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
WLSH3_k127_1019005_3	1123306.KB904358_gene842	1.673e-11	73.0	COG0785@1|root,COG0785@2|Bacteria,1V440@1239|Firmicutes,4HG5C@91061|Bacilli	91061|Bacilli	O	cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
WLSH3_k127_1019005_2	1191523.MROS_1341	5.404e-18	90.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Thioredoxin_8
WLSH3_k127_10194776_1	397948.Cmaq_1390	3.299e-36	153.0	COG0144@1|root,arCOG00975@2157|Archaea,2XQIC@28889|Crenarchaeota	28889|Crenarchaeota	J	Fmu (Sun) domain protein	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
WLSH3_k127_10194776_0	545243.BAEV01000016_gene2103	1.73e-54	212.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	gapN	-	1.2.1.9	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
WLSH3_k127_10203683_0	673860.AciM339_0564	3.149e-30	124.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,3F2R8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	ABC transporter	yvrO-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_10203683_1	266940.Krad_1348	0.000501	53.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_10218533_0	436308.Nmar_0948	2.918e-202	660.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
WLSH3_k127_10218533_2	745776.DGo_CA1666	3.13e-24	107.0	COG1661@1|root,COG1661@2|Bacteria	2|Bacteria	O	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
WLSH3_k127_10218533_1	706587.Desti_2326	2.84e-30	124.0	COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WS0J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
WLSH3_k127_10239853_0	880073.Calab_2584	2.884e-302	939.0	COG2987@1|root,COG2987@2|Bacteria,2NP09@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_0688	Urocanase,Urocanase_C,Urocanase_N
WLSH3_k127_10239853_5	684949.ATTJ01000001_gene1087	5.594e-26	117.0	2CAQ4@1|root,33YR3@2|Bacteria,1WMW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10239853_1	1499967.BAYZ01000026_gene1634	8.368e-177	569.0	COG2986@1|root,COG2986@2|Bacteria,2NNRU@2323|unclassified Bacteria	2|Bacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
WLSH3_k127_10239853_2	1089553.Tph_c20450	9.977e-134	438.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,42EXG@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
WLSH3_k127_10239853_3	515635.Dtur_1425	2.225e-39	154.0	COG2236@1|root,COG2236@2|Bacteria	2|Bacteria	F	xanthine phosphoribosyltransferase activity	gpt	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
WLSH3_k127_10239853_9	756883.Halar_3285	8.463e-07	58.0	COG1617@1|root,arCOG02197@2157|Archaea	2157|Archaea	H	KEOPS complex Cgi121-like subunit	cgi121	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
WLSH3_k127_10239853_6	1104324.P186_1589	3.721e-22	102.0	COG1818@1|root,arCOG00084@2157|Archaea	2157|Archaea	J	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
WLSH3_k127_10239853_4	415426.Hbut_0770	5.634e-34	141.0	COG0009@1|root,arCOG01952@2157|Archaea,2XPW0@28889|Crenarchaeota	28889|Crenarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
WLSH3_k127_10239853_7	304371.MCP_0802	2.683e-20	102.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
WLSH3_k127_10239853_8	1459636.NTE_01924	5.956e-20	97.0	COG0558@1|root,arCOG00670@2157|Archaea,41SJ7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
WLSH3_k127_10244549_1	679926.Mpet_2037	5.875e-72	254.0	COG1254@1|root,arCOG00643@2157|Archaea,2XVIJ@28890|Euryarchaeota	28890|Euryarchaeota	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
WLSH3_k127_10244549_0	453591.Igni_0393	1.107e-194	617.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
WLSH3_k127_10247293_2	1437448.AZRT01000067_gene1359	0.0004119	48.0	COG0739@1|root,COG2334@1|root,COG0739@2|Bacteria,COG2334@2|Bacteria,1MXTW@1224|Proteobacteria,2U31H@28211|Alphaproteobacteria,1J3M6@118882|Brucellaceae	28211|Alphaproteobacteria	M	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
WLSH3_k127_10247293_0	391009.Tmel_0564	4.492e-17	94.0	COG0747@1|root,COG0747@2|Bacteria,2GC1T@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
WLSH3_k127_10247293_1	138119.DSY3211	5.113e-08	65.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,248W4@186801|Clostridia,26135@186807|Peptococcaceae	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_10255052_0	269797.Mbar_A3613	4.778e-93	323.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
WLSH3_k127_10255052_1	272844.PAB0581	2.442e-84	296.0	COG0624@1|root,arCOG01107@2157|Archaea,2Y315@28890|Euryarchaeota,242ZX@183968|Thermococci	183968|Thermococci	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
WLSH3_k127_10255052_2	1365176.N186_04420	1.069e-23	104.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WLSH3_k127_10279781_1	868131.MSWAN_1425	2.647e-78	270.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
WLSH3_k127_10279781_0	1265505.ATUG01000001_gene3174	8.62e-108	365.0	COG1042@1|root,COG1042@2|Bacteria,1R8Q6@1224|Proteobacteria,42NR2@68525|delta/epsilon subdivisions,2WM2A@28221|Deltaproteobacteria,2MN2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
WLSH3_k127_10279781_2	1122138.AQUZ01000006_gene1299	1.872e-17	97.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria,4DTJQ@85009|Propionibacteriales	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
WLSH3_k127_10279781_3	1403819.BATR01000026_gene869	1.696e-12	81.0	COG3420@1|root,COG5184@1|root,COG3420@2|Bacteria,COG5184@2|Bacteria,46TZK@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_5,Pectinesterase
WLSH3_k127_10279781_4	410358.Mlab_1491	3.125e-10	72.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,2NB7I@224756|Methanomicrobia	224756|Methanomicrobia	D	Involved in cell shape control	cetZ	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
WLSH3_k127_10284657_3	868131.MSWAN_2253	0.0003164	52.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,23NM6@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_10284657_2	1265313.HRUBRA_02716	0.0001252	55.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,GDE_C
WLSH3_k127_10284657_0	1304284.L21TH_0179	1.144e-226	713.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36HQZ@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh,Pro_dh
WLSH3_k127_10284657_1	1123368.AUIS01000017_gene2569	1.641e-107	357.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1T3EM@1236|Gammaproteobacteria,2NBYU@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_10298199_1	926692.AZYG01000036_gene2582	3.131e-09	64.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF285,Flg_new,LRR_5,Lipase_GDSL_2,SLH,fn3
WLSH3_k127_10298199_0	768710.DesyoDRAFT_1409	3.496e-61	221.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_10314238_0	909663.KI867150_gene2225	3.665e-49	184.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,42SE8@68525|delta/epsilon subdivisions,2X5UM@28221|Deltaproteobacteria,2MSJM@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
WLSH3_k127_10314238_1	1123257.AUFV01000007_gene297	1.66e-29	122.0	COG4319@1|root,COG4319@2|Bacteria,1NHKV@1224|Proteobacteria,1T8CF@1236|Gammaproteobacteria,1XAF3@135614|Xanthomonadales	135614|Xanthomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
WLSH3_k127_10314238_2	1304888.ATWF01000002_gene205	2.17e-17	89.0	COG1433@1|root,COG1433@2|Bacteria,2GG4T@200930|Deferribacteres	200930|Deferribacteres	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
WLSH3_k127_10340642_2	868595.Desca_0401	1.918e-07	55.0	COG1695@1|root,COG1695@2|Bacteria,1VAP9@1239|Firmicutes,24QGK@186801|Clostridia,262MQ@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_10340642_1	1469948.JPNB01000002_gene3547	6.383e-12	68.0	2E5YB@1|root,330N1@2|Bacteria,1VEVQ@1239|Firmicutes,24RVC@186801|Clostridia,36N0A@31979|Clostridiaceae	186801|Clostridia	S	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
WLSH3_k127_10340642_0	290397.Adeh_2295	1.765e-13	71.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,42Y9Q@68525|delta/epsilon subdivisions,2WTQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WLSH3_k127_10356342_0	340099.Teth39_1630	5.419e-28	126.0	COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,42J13@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
WLSH3_k127_10356342_1	1123288.SOV_1c02350	9.999e-27	123.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_10362397_0	313624.NSP_14390	7.465e-06	55.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1HIQE@1161|Nostocales	1117|Cyanobacteria	K	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
WLSH3_k127_10366276_0	572478.Vdis_1394	4.884e-72	262.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WLSH3_k127_10376571_0	756883.Halar_3645	6.765e-59	207.0	COG1506@1|root,arCOG01646@2157|Archaea	2157|Archaea	E	Peptidase S9 prolyl oligopeptidase active site	pop	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
WLSH3_k127_10376571_1	443254.Marpi_0537	4.544e-16	86.0	COG1164@1|root,COG1164@2|Bacteria,2GCJ4@200918|Thermotogae	200918|Thermotogae	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
WLSH3_k127_10387593_0	760192.Halhy_0173	5.423e-262	832.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1IWK9@117747|Sphingobacteriia	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
WLSH3_k127_10387593_1	500153.JOEK01000009_gene5062	1.806e-93	316.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_10387593_2	1033743.CAES01000062_gene9	4.125e-64	228.0	COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes,4HB4C@91061|Bacilli,2777Z@186822|Paenibacillaceae	91061|Bacilli	E	YoaP-like	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
WLSH3_k127_10391883_0	1295642.H839_10603	2.199e-103	365.0	COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,4HACM@91061|Bacilli,1WHDB@129337|Geobacillus	91061|Bacilli	S	Penicillin amidase	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
WLSH3_k127_10391883_1	490899.DKAM_0117	9.952e-78	269.0	COG0448@1|root,arCOG00912@2157|Archaea,2XPXX@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
WLSH3_k127_10407877_15	1459636.NTE_01027	4.218e-70	254.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_10407877_17	69014.TK1688	3.082e-62	224.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
WLSH3_k127_10407877_18	933801.Ahos_1246	1.393e-54	201.0	COG1100@1|root,arCOG01225@2157|Archaea,2XQ2Q@28889|Crenarchaeota	28889|Crenarchaeota	S	ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
WLSH3_k127_10407877_24	386456.JQKN01000002_gene2681	1.291e-39	160.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
WLSH3_k127_10407877_40	1365176.N186_04650	4.015e-10	66.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
WLSH3_k127_10407877_21	342949.PNA2_1531	3.267e-44	167.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2433T@183968|Thermococci	183968|Thermococci	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
WLSH3_k127_10407877_12	243232.MJ_1494	4.332e-101	342.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,23Q25@183939|Methanococci	183939|Methanococci	O	PFAM AAA ATPase central domain protein	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
WLSH3_k127_10407877_27	1198449.ACAM_1123	6.962e-36	143.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
WLSH3_k127_10407877_14	224325.AF_0130	7.639e-82	284.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
WLSH3_k127_10407877_1	192952.MM_0425	3.343e-180	589.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
WLSH3_k127_10407877_4	415426.Hbut_0903	3.355e-168	552.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
WLSH3_k127_10407877_11	573064.Mefer_1399	1.333e-104	348.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
WLSH3_k127_10407877_16	415426.Hbut_0906	2.46e-65	238.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
WLSH3_k127_10407877_26	572546.Arcpr_0332	4.614e-38	153.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,24670@183980|Archaeoglobi	183980|Archaeoglobi	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
WLSH3_k127_10407877_41	572478.Vdis_0003	2.365e-09	61.0	COG0640@1|root,arCOG04056@2157|Archaea,2XR0A@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
WLSH3_k127_10407877_13	415426.Hbut_0909	4.069e-88	306.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
WLSH3_k127_10407877_34	429009.Adeg_1808	6.521e-20	98.0	COG2452@1|root,COG2452@2|Bacteria,1UZS8@1239|Firmicutes,24CER@186801|Clostridia,42HX7@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA binding domain protein, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Resolvase
WLSH3_k127_10407877_10	573063.Metin_0090	3.324e-107	359.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23RI4@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_10407877_38	1227453.C444_04032	8.124e-13	79.0	COG1405@1|root,arCOG01981@2157|Archaea	2157|Archaea	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_10407877_31	999630.TUZN_0906	3.415e-24	118.0	COG4962@1|root,arCOG01817@2157|Archaea,2XQ1I@28889|Crenarchaeota	28889|Crenarchaeota	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
WLSH3_k127_10407877_43	69014.TK0421	6.681e-05	45.0	arCOG07843@1|root,arCOG07843@2157|Archaea	69014.TK0421|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10407877_36	471852.Tcur_0645	7.4e-19	103.0	COG0433@1|root,COG0433@2|Bacteria,2HUQ5@201174|Actinobacteria,4EG3P@85012|Streptosporangiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF853
WLSH3_k127_10407877_30	1220534.B655_1466	5.775e-34	141.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WLSH3_k127_10407877_25	269797.Mbar_A3684	3.335e-39	148.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,2N9T3@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WLSH3_k127_10407877_2	246969.TAM4_485	8.269e-176	569.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
WLSH3_k127_10407877_19	1121864.OMO_01158	1.08e-47	187.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,4AZ5U@81852|Enterococcaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
WLSH3_k127_10407877_32	868131.MSWAN_2140	6.582e-23	110.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_10407877_42	351160.RCIX2718	1.254e-06	58.0	arCOG04038@1|root,arCOG04038@2157|Archaea,2Y5TS@28890|Euryarchaeota,2NBDA@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10407877_6	529818.AMSG_04122T0	3.87e-132	435.0	COG1748@1|root,KOG0172@2759|Eukaryota	2759|Eukaryota	E	saccharopine dehydrogenase activity	LYS9	GO:0003674,GO:0003824,GO:0004753,GO:0004755,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.10,2.5.1.16	ko:K00293,ko:K00797	ko00270,ko00300,ko00310,ko00330,ko00410,ko00480,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00310,map00330,map00410,map00480,map01100,map01110,map01130,map01230	M00030,M00032,M00034,M00133	R01920,R02315,R02869,R08359	RC00021,RC00053,RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP,Spermine_synt_N,Spermine_synth
WLSH3_k127_10407877_7	1499967.BAYZ01000013_gene6446	6.491e-132	433.0	COG0686@1|root,COG0686@2|Bacteria,2NNTE@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	sdh	-	1.5.1.7,1.5.1.8,1.5.1.9	ko:K00290,ko:K14157	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R00716,R02313	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
WLSH3_k127_10407877_3	673860.AciM339_0762	6.099e-175	568.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
WLSH3_k127_10407877_23	391623.TERMP_01314	8.416e-41	159.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242YZ@183968|Thermococci	183968|Thermococci	C	Indolepyruvate ferredoxin oxidoreductase subunit	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
WLSH3_k127_10407877_0	877455.Metbo_0232	1.166e-198	645.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
WLSH3_k127_10407877_8	69014.TK0139	2.959e-119	400.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242UT@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
WLSH3_k127_10407877_20	386456.JQKN01000007_gene3353	8.626e-47	176.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,23NYI@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
WLSH3_k127_10407877_33	391623.TERMP_01563	1.105e-20	96.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,244FN@183968|Thermococci	183968|Thermococci	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
WLSH3_k127_10407877_22	348780.NP_1360A	3.278e-42	166.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,23RZ2@183963|Halobacteria	183963|Halobacteria	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
WLSH3_k127_10407877_5	572546.Arcpr_1629	1.619e-141	460.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
WLSH3_k127_10407877_37	186497.PF0512	1.249e-15	84.0	COG1813@1|root,arCOG01863@2157|Archaea,2XWZV@28890|Euryarchaeota,242VJ@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
WLSH3_k127_10407877_28	195522.BD01_1951	1.599e-34	138.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2438P@183968|Thermococci	183968|Thermococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
WLSH3_k127_10407877_29	195522.BD01_1950	4.539e-34	141.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
WLSH3_k127_10407877_9	515635.Dtur_0462	1.223e-107	364.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	bglB	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
WLSH3_k127_10407877_35	269799.Gmet_1157	7.26e-20	96.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,42U2Q@68525|delta/epsilon subdivisions,2WQK9@28221|Deltaproteobacteria,43UPT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Membrane protein, UPF0016 and UPF0016 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
WLSH3_k127_10407877_39	633148.Tagg_0159	3.595e-10	63.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
WLSH3_k127_10434978_2	690850.Desaf_1978	2.097e-22	99.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42SXB@68525|delta/epsilon subdivisions,2WPP2@28221|Deltaproteobacteria,2MBMY@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
WLSH3_k127_10434978_1	1365176.N186_06015	4.637e-116	386.0	COG1488@1|root,arCOG01481@2157|Archaea,2XPRU@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Quinolinate phosphoribosyl transferase	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
WLSH3_k127_10434978_0	555088.DealDRAFT_2538	5.853e-213	672.0	COG1960@1|root,COG1960@2|Bacteria,1V03D@1239|Firmicutes,24A8N@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
WLSH3_k127_10466004_1	795797.C497_10083	1.236e-17	94.0	arCOG02979@1|root,arCOG02979@2157|Archaea,2XT08@28890|Euryarchaeota,23SPH@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10466004_0	453591.Igni_1108	9.873e-90	314.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
WLSH3_k127_10466004_2	879310.HMPREF9162_1760	3.193e-10	64.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes	1239|Firmicutes	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
WLSH3_k127_10491341_1	269799.Gmet_2012	1.74e-42	173.0	COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,43AEC@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
WLSH3_k127_10491341_0	1123399.AQVE01000007_gene1108	3.72e-66	237.0	COG2227@1|root,COG2227@2|Bacteria,1R1WF@1224|Proteobacteria,1T5CF@1236|Gammaproteobacteria,46344@72273|Thiotrichales	72273|Thiotrichales	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
WLSH3_k127_10504871_1	632335.Calkr_0644	6.841e-67	236.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_10504871_0	768672.Desfe_0502	4.426e-102	341.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_10504871_2	159087.Daro_3843	2.607e-21	100.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KVJT@206389|Rhodocyclales	206389|Rhodocyclales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
WLSH3_k127_10513258_0	694429.Pyrfu_0001	5.106e-12	77.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPXH@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
WLSH3_k127_1051676_0	402777.KB235898_gene5591	2.487e-35	152.0	COG5316@1|root,COG5316@2|Bacteria,1G2S6@1117|Cyanobacteria,1HA82@1150|Oscillatoriales	1117|Cyanobacteria	S	TIGRFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
WLSH3_k127_1051676_1	1206732.BAGD01000024_gene456	2.92e-05	51.0	COG5316@1|root,COG5316@2|Bacteria,2GN81@201174|Actinobacteria,4FZQT@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
WLSH3_k127_10534912_2	419665.Maeo_0095	2.159e-22	101.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
WLSH3_k127_10534912_4	1499967.BAYZ01000171_gene5564	2.036e-21	100.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
WLSH3_k127_10534912_1	439235.Dalk_5067	3.707e-58	213.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MJQR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	heterodisulfide reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_10534912_0	523845.AQXV01000051_gene1217	3.483e-144	469.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
WLSH3_k127_10534912_3	429009.Adeg_1885	1.754e-21	98.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
WLSH3_k127_10543577_2	444158.MmarC6_0974	5.468e-59	219.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
WLSH3_k127_10543577_4	1459636.NTE_02786	4.578e-47	174.0	COG4275@1|root,arCOG10427@2157|Archaea	2157|Archaea	S	Chromate resistance	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
WLSH3_k127_10543577_0	1123392.AQWL01000004_gene2612	5.126e-73	261.0	COG0477@1|root,COG2814@2|Bacteria,1RB5E@1224|Proteobacteria,2VQNK@28216|Betaproteobacteria,1KSII@119069|Hydrogenophilales	119069|Hydrogenophilales	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
WLSH3_k127_10543577_1	456320.Mvol_0794	1.565e-68	243.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_10543577_5	304371.MCP_1578	3.854e-28	119.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,2N9VF@224756|Methanomicrobia	224756|Methanomicrobia	C	heterodisulfide reductase subunit C	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
WLSH3_k127_10543577_3	933262.AXAM01000056_gene3179	5.368e-51	186.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1R68U@1224|Proteobacteria,42M71@68525|delta/epsilon subdivisions,2WKG0@28221|Deltaproteobacteria,2MJ02@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD
WLSH3_k127_10557126_1	1125863.JAFN01000001_gene3506	5.656e-30	126.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
WLSH3_k127_10557126_0	693661.Arcve_1710	1.427e-89	315.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,245U4@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos
WLSH3_k127_10557751_0	272562.CA_C2199	2.096e-114	389.0	COG3882@1|root,COG3882@2|Bacteria,1TTCC@1239|Firmicutes,24A4U@186801|Clostridia,36G4Q@31979|Clostridiaceae	186801|Clostridia	Q	HAD-superfamily phosphatase, subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	NIF
WLSH3_k127_10557751_1	760142.Hipma_0586	1.745e-14	81.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,42TWY@68525|delta/epsilon subdivisions,2WQEP@28221|Deltaproteobacteria,2M7D1@213113|Desulfurellales	28221|Deltaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
WLSH3_k127_10557751_2	671065.MetMK1DRAFT_00028920	2.389e-05	53.0	COG1061@1|root,arCOG00874@2157|Archaea,2XQ1C@28889|Crenarchaeota	28889|Crenarchaeota	K	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,ResIII
WLSH3_k127_10562667_2	491952.Mar181_1164	7.634e-11	64.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
WLSH3_k127_10562667_0	694429.Pyrfu_0023	8.972e-66	236.0	COG0492@1|root,arCOG01296@2157|Archaea,2XPQC@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WLSH3_k127_10562667_3	1262449.CP6013_3415	4.411e-07	55.0	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,36N2I@31979|Clostridiaceae	186801|Clostridia	O	glutaredoxin-like protein, YruB-family	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
WLSH3_k127_10562667_1	768672.Desfe_0703	8.467e-28	118.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WLSH3_k127_10568024_0	519442.Huta_2288	9.098e-27	114.0	arCOG14997@1|root,arCOG14997@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10572836_2	1407650.BAUB01000001_gene288	2.121e-07	63.0	COG1266@1|root,COG1266@2|Bacteria,1G0ZJ@1117|Cyanobacteria,1GZ8P@1129|Synechococcus	1117|Cyanobacteria	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_10572836_0	1112204.GPOL_c15200	3.953e-28	126.0	2ERKW@1|root,33J6D@2|Bacteria,2I7F1@201174|Actinobacteria,4GGVG@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10572836_1	1461694.ATO9_09600	1.433e-18	98.0	28IVP@1|root,2Z8U1@2|Bacteria,1QWF9@1224|Proteobacteria,2UFWI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10573911_0	1449063.JMLS01000001_gene4321	3.94e-13	79.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,26QDE@186822|Paenibacillaceae	91061|Bacilli	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,PUCC,Sugar_tr
WLSH3_k127_10574883_0	439235.Dalk_0164	1.393e-157	518.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
WLSH3_k127_10580045_2	1408422.JHYF01000004_gene1563	1.824e-19	93.0	COG0346@1|root,COG0346@2|Bacteria,1VC53@1239|Firmicutes,24ICT@186801|Clostridia,36IP2@31979|Clostridiaceae	186801|Clostridia	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
WLSH3_k127_10580045_4	1157490.EL26_16850	3.482e-09	64.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli,278GA@186823|Alicyclobacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_10580045_0	536019.Mesop_4520	2.594e-122	401.0	COG0031@1|root,COG0031@2|Bacteria,1Q4JV@1224|Proteobacteria,2VG8H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_10580045_1	406124.ACPC01000010_gene2270	2.358e-37	145.0	2DNQ8@1|root,32YJ3@2|Bacteria,1VHCH@1239|Firmicutes,4HQ4Q@91061|Bacilli,1ZJ8K@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10589204_1	880073.Calab_1834	2.961e-14	84.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
WLSH3_k127_10589204_0	398512.JQKC01000027_gene3915	2.61e-69	250.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WLSH3_k127_10589204_2	1365176.N186_00290	4.067e-10	70.0	COG5014@1|root,arCOG05120@2157|Archaea,2XPWW@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_10589204_3	439481.Aboo_0424	3.6e-09	62.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y70G@28890|Euryarchaeota,3F32Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10605380_3	351160.RCIX2175	9.118e-22	95.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,2N9EN@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
WLSH3_k127_10605380_0	877455.Metbo_1103	0.0	1052.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,23NKS@183925|Methanobacteria	183925|Methanobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WLSH3_k127_10605380_1	574087.Acear_0289	2.153e-150	496.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
WLSH3_k127_10605380_5	195522.BD01_2210	3.106e-05	49.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y1HH@28890|Euryarchaeota,244RQ@183968|Thermococci	183968|Thermococci	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
WLSH3_k127_10605380_4	374847.Kcr_0871	3.455e-10	64.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_11,HTH_24
WLSH3_k127_10605380_2	374847.Kcr_0873	5.762e-52	197.0	COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
WLSH3_k127_10609941_0	269797.Mbar_A1752	2.671e-49	190.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
WLSH3_k127_10609941_2	391623.TERMP_01771	1.316e-24	106.0	COG1917@1|root,arCOG02994@2157|Archaea,2XZAN@28890|Euryarchaeota,2446X@183968|Thermococci	183968|Thermococci	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_10609941_3	1382356.JQMP01000004_gene190	2.133e-21	104.0	COG0647@1|root,COG0647@2|Bacteria,2GA3K@200795|Chloroflexi,27Z1Q@189775|Thermomicrobia	189775|Thermomicrobia	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
WLSH3_k127_10609941_1	1041930.Mtc_1769	1.396e-28	124.0	COG3382@1|root,arCOG04250@2157|Archaea,2Y2KD@28890|Euryarchaeota,2NAIE@224756|Methanomicrobia	224756|Methanomicrobia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
WLSH3_k127_10614992_0	385682.AFSL01000105_gene124	4.08e-56	203.0	COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,2FPB3@200643|Bacteroidia,3XJEI@558415|Marinilabiliaceae	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_10639349_3	688269.Theth_1245	5.034e-13	71.0	COG0332@1|root,COG0332@2|Bacteria,2GC8A@200918|Thermotogae	200918|Thermotogae	I	PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
WLSH3_k127_10639349_1	1304885.AUEY01000094_gene3532	3.583e-44	164.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,42SWX@68525|delta/epsilon subdivisions,2WPJ0@28221|Deltaproteobacteria,2MK5C@213118|Desulfobacterales	28221|Deltaproteobacteria	I	MaoC like domain	maoC	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
WLSH3_k127_10639349_2	1210908.HSB1_26060	6.837e-36	146.0	COG1234@1|root,arCOG00500@2157|Archaea,2XTUD@28890|Euryarchaeota,23STE@183963|Halobacteria	183963|Halobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
WLSH3_k127_10639349_0	368408.Tpen_1035	2.345e-70	246.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
WLSH3_k127_10663292_0	1177154.Y5S_00345	0.0003578	51.0	COG0406@1|root,COG0406@2|Bacteria,1RDG9@1224|Proteobacteria,1S5TU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WLSH3_k127_10663578_3	1379270.AUXF01000004_gene3184	4.406e-06	51.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	ATC_hydrolase,SWIM
WLSH3_k127_10663578_2	1220534.B655_1002	3.69e-17	96.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
WLSH3_k127_10663578_1	521011.Mpal_1494	1.1e-38	147.0	COG5507@1|root,arCOG09468@2157|Archaea,2Y13Q@28890|Euryarchaeota,2NB85@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
WLSH3_k127_10663578_0	1117379.BABA_04409	1.319e-90	301.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,4HDPM@91061|Bacilli,1ZR5K@1386|Bacillus	91061|Bacilli	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
WLSH3_k127_10665941_0	357808.RoseRS_1928	3.012e-06	59.0	COG0501@1|root,COG0501@2|Bacteria,2G6UV@200795|Chloroflexi,376TM@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase M48 Ste24p	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
WLSH3_k127_10665941_1	629265.PMA4326_23601	0.0009967	46.0	COG0526@1|root,COG0526@2|Bacteria,1P0KR@1224|Proteobacteria,1SGVT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH3_k127_10679851_1	351160.RCIX51	1.038e-105	352.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_10679851_7	42256.RradSPS_0281	1.727e-05	55.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
WLSH3_k127_10679851_2	765177.Desmu_0728	1.419e-102	349.0	COG1571@1|root,arCOG01115@2157|Archaea,2XPN1@28889|Crenarchaeota	28889|Crenarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
WLSH3_k127_10679851_6	397948.Cmaq_1120	9.181e-06	51.0	arCOG07221@1|root,arCOG07221@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-HIT
WLSH3_k127_10679851_3	243232.MJ_0708	8.635e-43	166.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,23QSJ@183939|Methanococci	183939|Methanococci	J	pre-rRNA processing protein involved in ribosome biogenesis	-	GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
WLSH3_k127_10679851_0	386456.JQKN01000001_gene1733	1.559e-112	373.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,23NQV@183925|Methanobacteria	183925|Methanobacteria	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
WLSH3_k127_10679851_5	1365176.N186_03270	2.019e-30	122.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
WLSH3_k127_10679851_4	243232.MJ_0656	2.828e-41	160.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,23QTJ@183939|Methanococci	183939|Methanococci	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
WLSH3_k127_1068432_1	1459636.NTE_02553	3.353e-08	60.0	COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
WLSH3_k127_1068432_2	909663.KI867151_gene2980	6.083e-08	61.0	COG0838@1|root,COG0838@2|Bacteria,1PPP3@1224|Proteobacteria,42VF4@68525|delta/epsilon subdivisions,2WRIV@28221|Deltaproteobacteria,2MQKR@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
WLSH3_k127_1068432_0	933801.Ahos_0544	5.428e-37	156.0	COG0377@1|root,arCOG01554@2157|Archaea,2XQCS@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the complex I 20 kDa subunit family	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
WLSH3_k127_10685171_0	485913.Krac_10989	3.275e-128	415.0	COG1061@1|root,COG1061@2|Bacteria,2G861@200795|Chloroflexi	200795|Chloroflexi	L	type III restriction protein res subunit	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
WLSH3_k127_10685171_1	797209.ZOD2009_18155	4.433e-25	115.0	COG0467@1|root,arCOG01171@2157|Archaea,2XW8E@28890|Euryarchaeota,23UNA@183963|Halobacteria	183963|Halobacteria	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase,zf-FCS
WLSH3_k127_10734428_2	391623.TERMP_00361	1.57e-08	58.0	COG0735@1|root,arCOG01868@2157|Archaea,2Y1GV@28890|Euryarchaeota,245J3@183968|Thermococci	183968|Thermococci	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
WLSH3_k127_10734428_0	926561.KB900622_gene463	2.222e-25	109.0	29X3G@1|root,30IS5@2|Bacteria,1W5BE@1239|Firmicutes,24MZE@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
WLSH3_k127_10734428_1	641491.DND132_1339	1.189e-16	89.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,42PNR@68525|delta/epsilon subdivisions,2WKJT@28221|Deltaproteobacteria,2M9WW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_16,Fer4_7
WLSH3_k127_10734428_3	667015.Bacsa_0383	4.18e-05	49.0	arCOG08935@1|root,32Z08@2|Bacteria,4NU81@976|Bacteroidetes,2FUBF@200643|Bacteroidia,4AUJ3@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10741785_0	321327.CYA_2306	1.579e-157	513.0	COG1501@1|root,COG1501@2|Bacteria,1G3UD@1117|Cyanobacteria,1H2JX@1129|Synechococcus	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
WLSH3_k127_10741785_2	69014.TK1688	7.588e-68	239.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
WLSH3_k127_10741785_1	342949.PNA2_1365	2.279e-98	329.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
WLSH3_k127_10741785_3	1304888.ATWF01000001_gene1175	2.382e-59	210.0	COG2131@1|root,COG2131@2|Bacteria,2GFK7@200930|Deferribacteres	200930|Deferribacteres	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
WLSH3_k127_10741785_7	192952.MM_1557	1.505e-11	69.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68X@28890|Euryarchaeota,2NA5V@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
WLSH3_k127_10741785_5	1183377.Py04_1673	5.579e-16	79.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,244GS@183968|Thermococci	183968|Thermococci	J	H ACA RNA-protein complex	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
WLSH3_k127_10741785_4	644281.MFS40622_0553	1.718e-40	158.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,23QIM@183939|Methanococci	183939|Methanococci	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
WLSH3_k127_10741785_6	877455.Metbo_0334	4.053e-13	75.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
WLSH3_k127_10749753_1	1227349.C170_29198	9.909e-37	155.0	COG0454@1|root,COG0456@2|Bacteria,1TQQA@1239|Firmicutes,4HBXN@91061|Bacilli,26RQ4@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
WLSH3_k127_10749753_0	765177.Desmu_0315	4.787e-108	356.0	COG1350@1|root,arCOG01432@2157|Archaea,2XQ0U@28889|Crenarchaeota	28889|Crenarchaeota	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_10757778_1	1123288.SOV_2c11770	1.119e-05	52.0	COG0491@1|root,COG0491@2|Bacteria,1V2XF@1239|Firmicutes	1239|Firmicutes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_10757778_0	1042877.GQS_07890	3.846e-119	399.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,242VY@183968|Thermococci	183968|Thermococci	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
WLSH3_k127_1079305_1	521045.Kole_1546	1.964e-17	82.0	COG4608@1|root,COG4608@2|Bacteria,2GC6X@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_1079305_2	591157.SSLG_04885	5.364e-08	63.0	COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria	201174|Actinobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
WLSH3_k127_1079305_0	1382306.JNIM01000001_gene1897	9.237e-82	281.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM LPPG domain protein containing protein	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
WLSH3_k127_1081600_5	7230.FBpp0173033	1.664e-40	163.0	COG1287@1|root,KOG2292@2759|Eukaryota,38D8E@33154|Opisthokonta,3B9KS@33208|Metazoa,3CXTS@33213|Bilateria,41V4J@6656|Arthropoda,3SJTP@50557|Insecta,4510A@7147|Diptera,45NKE@7214|Drosophilidae	33208|Metazoa	O	Oligosaccharyl transferase activity. It is involved in the biological process described with protein glycosylation	STT3B	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006508,GO:0006511,GO:0006516,GO:0006807,GO:0006950,GO:0006986,GO:0008150,GO:0008152,GO:0008250,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0019941,GO:0030163,GO:0030433,GO:0031984,GO:0032991,GO:0033554,GO:0034645,GO:0034976,GO:0035966,GO:0036211,GO:0036503,GO:0042175,GO:0042221,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043632,GO:0043686,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051603,GO:0051716,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901136,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
WLSH3_k127_1081600_6	309801.trd_0752	6.336e-37	143.0	COG0509@1|root,COG0509@2|Bacteria,2G6XE@200795|Chloroflexi,27YEK@189775|Thermomicrobia	189775|Thermomicrobia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
WLSH3_k127_1081600_2	471223.GWCH70_2361	5.626e-86	298.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,1WFB5@129337|Geobacillus	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
WLSH3_k127_1081600_3	186497.PF1296	9.243e-54	204.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y878@28890|Euryarchaeota,245MF@183968|Thermococci	183968|Thermococci	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
WLSH3_k127_1081600_4	391623.TERMP_01266	1.811e-44	170.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,24344@183968|Thermococci	183968|Thermococci	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
WLSH3_k127_1081600_8	4155.Migut.J00776.1.p	2.5e-06	55.0	KOG3356@1|root,KOG3356@2759|Eukaryota,37TRW@33090|Viridiplantae,3GHZU@35493|Streptophyta,44EK1@71274|asterids	35493|Streptophyta	S	OST3 / OST6 family, transporter family	-	-	-	-	-	-	-	-	-	-	-	-	OST3_OST6
WLSH3_k127_1081600_0	1343739.PAP_05975	3.422e-159	526.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
WLSH3_k127_1081600_7	633148.Tagg_0170	1.549e-10	66.0	COG0550@1|root,arCOG01527@2157|Archaea,2XQ00@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA topoisomerase, type IA, central domain protein	topA	-	5.99.1.2	ko:K03168,ko:K03169	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
WLSH3_k127_1081600_1	1343739.PAP_05515	5.013e-125	424.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
WLSH3_k127_10833026_1	646529.Desaci_2816	3.299e-46	173.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,264QI@186807|Peptococcaceae	186801|Clostridia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
WLSH3_k127_10833026_0	555079.Toce_1834	2.433e-163	523.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
WLSH3_k127_10854466_2	224325.AF_1060	2.235e-52	204.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,246V1@183980|Archaeoglobi	183980|Archaeoglobi	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
WLSH3_k127_10854466_5	415426.Hbut_0073	3.006e-12	71.0	COG0640@1|root,arCOG01679@2157|Archaea,2XR0G@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_10854466_1	1041930.Mtc_0872	1.272e-96	341.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
WLSH3_k127_10854466_4	386456.JQKN01000002_gene2402	5.18e-13	72.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,23P7B@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
WLSH3_k127_10854466_0	868131.MSWAN_2418	3.094e-115	380.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
WLSH3_k127_10854466_3	69014.TK0679	5.642e-43	164.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
WLSH3_k127_10864039_6	1223410.KN050846_gene1848	2.494e-05	55.0	COG1404@1|root,COG1404@2|Bacteria,4NFMW@976|Bacteroidetes,1I06M@117743|Flavobacteriia	976|Bacteroidetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PKD,Peptidase_S8
WLSH3_k127_10864039_2	1463858.JOHR01000006_gene416	3.172e-26	119.0	COG3315@1|root,COG3315@2|Bacteria,2GKDZ@201174|Actinobacteria	201174|Actinobacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
WLSH3_k127_10864039_5	1235803.C825_04483	2.215e-06	59.0	COG3594@1|root,COG3594@2|Bacteria,4NV7P@976|Bacteroidetes,2FUUX@200643|Bacteroidia,2310Y@171551|Porphyromonadaceae	976|Bacteroidetes	G	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
WLSH3_k127_10864039_4	926569.ANT_27110	2.674e-07	61.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10864039_0	251221.35211855	5.407e-99	339.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
WLSH3_k127_10864039_1	945713.IALB_3117	5.717e-41	157.0	2DTJ6@1|root,33KM6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10864039_3	1123242.JH636434_gene5321	7.701e-22	96.0	COG2335@1|root,COG2335@2|Bacteria,2IZDI@203682|Planctomycetes	203682|Planctomycetes	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
WLSH3_k127_10866102_4	665571.STHERM_c17760	6.064e-43	162.0	COG0274@1|root,COG0274@2|Bacteria,2J7GA@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
WLSH3_k127_10866102_1	246194.CHY_0789	2.117e-184	594.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
WLSH3_k127_10866102_2	192952.MM_0883	2.166e-131	443.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
WLSH3_k127_10866102_5	572546.Arcpr_1573	2.516e-30	125.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,2467U@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
WLSH3_k127_10866102_8	436308.Nmar_1224	3.559e-07	55.0	arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10866102_0	694429.Pyrfu_0111	6.749e-275	864.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
WLSH3_k127_10866102_6	399550.Smar_0716	1.167e-21	96.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
WLSH3_k127_10866102_7	415426.Hbut_1353	3.105e-15	77.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
WLSH3_k127_10866102_3	673860.AciM339_0552	5.745e-87	295.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
WLSH3_k127_10879316_4	316058.RPB_1823	5.193e-10	70.0	2FD28@1|root,3454Q@2|Bacteria,1P0UH@1224|Proteobacteria,2UV1E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10879316_2	517418.Ctha_0501	2.014e-54	193.0	COG0229@1|root,COG0229@2|Bacteria,1FDWG@1090|Chlorobi	1090|Chlorobi	C	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
WLSH3_k127_10879316_3	314230.DSM3645_26399	7.892e-15	87.0	COG3049@1|root,COG3049@2|Bacteria,2J1Z0@203682|Planctomycetes	203682|Planctomycetes	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10879316_1	574087.Acear_1505	1.822e-56	206.0	COG0778@1|root,COG0778@2|Bacteria,1UZC3@1239|Firmicutes,24BKG@186801|Clostridia,3WBQ2@53433|Halanaerobiales	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
WLSH3_k127_10879316_0	1499967.BAYZ01000026_gene1636	9.266e-58	205.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
WLSH3_k127_10892447_1	1183377.Py04_0773	5.044e-11	64.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2441Z@183968|Thermococci	183968|Thermococci	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
WLSH3_k127_10892447_0	1157490.EL26_11975	7.405e-48	189.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
WLSH3_k127_10907076_1	1385517.N800_09390	3.497e-14	80.0	COG3157@1|root,COG3157@2|Bacteria,1RC8U@1224|Proteobacteria,1S3BY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
WLSH3_k127_10907076_0	443143.GM18_1106	1.06e-29	127.0	COG2373@1|root,COG2931@1|root,COG4932@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	A2M,An_peroxidase,CHRD,CarboxypepD_reg
WLSH3_k127_10907076_2	694427.Palpr_2116	6.521e-07	59.0	COG3656@1|root,COG4886@1|root,COG3656@2|Bacteria,COG4886@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia,22Y91@171551|Porphyromonadaceae	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_10925010_0	1343739.PAP_06100	9.122e-107	380.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
WLSH3_k127_10925010_1	7668.SPU_005782-tr	4.437e-26	124.0	COG1100@1|root,KOG0395@2759|Eukaryota,39D71@33154|Opisthokonta,3BMYE@33208|Metazoa,3D5GM@33213|Bilateria	33208|Metazoa	S	Sec23/Sec24 zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	Ras,zf-Sec23_Sec24
WLSH3_k127_10925010_3	109760.SPPG_05221T0	1.727e-12	72.0	KOG4115@1|root,KOG4115@2759|Eukaryota,3A3F9@33154|Opisthokonta,3P6RS@4751|Fungi	4751|Fungi	DN	Dynein light chain	-	-	-	ko:K10419	-	-	-	-	ko00000,ko04131,ko04812	-	-	-	Robl_LC7
WLSH3_k127_10925010_4	877455.Metbo_0652	9.089e-09	63.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_10925010_2	1123388.AQWU01000072_gene1336	1.362e-17	88.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
WLSH3_k127_10938427_0	1220534.B655_1154	9.296e-38	151.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
WLSH3_k127_10938427_1	368407.Memar_0884	2.849e-17	94.0	COG0642@1|root,COG2202@1|root,arCOG06192@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_10939707_3	1313421.JHBV01000015_gene5750	1.183e-07	56.0	COG5492@1|root,COG5492@2|Bacteria,4NY38@976|Bacteroidetes	976|Bacteroidetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10939707_4	1145276.T479_02070	0.0003204	50.0	COG0454@1|root,COG0456@2|Bacteria,1V2G9@1239|Firmicutes,4HG4X@91061|Bacilli,3IW4B@400634|Lysinibacillus	91061|Bacilli	K	GNAT family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
WLSH3_k127_10939707_1	690850.Desaf_2977	3.263e-83	283.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2M9ST@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
WLSH3_k127_10939707_0	1499689.CCNN01000007_gene867	2.475e-136	451.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,36FKP@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0371 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
WLSH3_k127_10939707_2	1122194.AUHU01000002_gene2710	1.98e-36	145.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,4674R@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Hydrolase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
WLSH3_k127_10966495_0	403833.Pmob_1549	5.932e-115	383.0	COG0156@1|root,COG0156@2|Bacteria,2GCC8@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_10989401_0	572544.Ilyop_1530	3.381e-32	133.0	COG1744@1|root,COG1744@2|Bacteria,3796B@32066|Fusobacteria	32066|Fusobacteria	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
WLSH3_k127_11015571_1	1163730.FFONT_0114	2.822e-09	67.0	COG0637@1|root,arCOG02293@2157|Archaea	2157|Archaea	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
WLSH3_k127_11015571_0	1220534.B655_1873	5.998e-84	289.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,23NN6@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
WLSH3_k127_11015571_2	1198449.ACAM_0711	0.0007497	46.0	COG0061@1|root,arCOG01348@2157|Archaea,2XQS3@28889|Crenarchaeota	28889|Crenarchaeota	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
WLSH3_k127_1101832_1	643867.Ftrac_1703	0.0001863	52.0	28W66@1|root,2ZI6U@2|Bacteria,4P8V7@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1101832_0	485918.Cpin_2593	7.384e-33	147.0	COG1470@1|root,COG1470@2|Bacteria,4P0GS@976|Bacteroidetes	976|Bacteroidetes	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_11027104_0	1304284.L21TH_0519	1.108e-67	239.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_11046498_1	933801.Ahos_0498	6.209e-49	181.0	COG1573@1|root,arCOG00905@2157|Archaea,2XQ7T@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
WLSH3_k127_11046498_0	529709.PYCH_15740	2.627e-235	742.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3
WLSH3_k127_11048847_1	717606.PaecuDRAFT_2033	1.136e-52	199.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
WLSH3_k127_11048847_2	1379698.RBG1_1C00001G0217	6.422e-15	87.0	COG1520@1|root,COG1520@2|Bacteria,2NQ51@2323|unclassified Bacteria	2|Bacteria	O	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,PQQ_2,SBBP
WLSH3_k127_11048847_0	1499967.BAYZ01000156_gene556	7.427e-69	240.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
WLSH3_k127_11048847_3	1123288.SOV_1c04490	0.0001193	46.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,4H6SI@909932|Negativicutes	909932|Negativicutes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
WLSH3_k127_1107673_0	1094980.Mpsy_1310	3.128e-50	186.0	COG1035@1|root,COG3350@1|root,arCOG02650@2157|Archaea,arCOG04507@2157|Archaea,2Y7JA@28890|Euryarchaeota,2NAMA@224756|Methanomicrobia	224756|Methanomicrobia	C	YHS domain	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N,YHS
WLSH3_k127_1107673_1	7668.SPU_028311-tr	2.692e-28	120.0	COG1618@1|root,2QVJ8@2759|Eukaryota,38FT1@33154|Opisthokonta,3BGUB@33208|Metazoa,3CSDG@33213|Bilateria	33208|Metazoa	O	nucleotide phosphatase activity, acting on free nucleotides	NTPCR	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
WLSH3_k127_11116937_1	877455.Metbo_0863	7.665e-94	323.0	COG1035@1|root,COG1941@1|root,arCOG02473@2157|Archaea,arCOG02652@2157|Archaea,2XZ31@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
WLSH3_k127_11116937_0	161156.JQKW01000008_gene453	1.229e-107	362.0	COG2244@1|root,COG2244@2|Bacteria,2GIK9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
WLSH3_k127_11122833_3	192952.MM_3216	2.996e-09	62.0	COG2512@1|root,arCOG00377@2157|Archaea	2157|Archaea	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_11122833_1	340099.Teth39_0903	3.463e-56	203.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42G8Z@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
WLSH3_k127_11122833_0	864563.HMPREF9166_2036	1.503e-95	324.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,4H1WI@909932|Negativicutes	909932|Negativicutes	E	LAO AO transport system	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
WLSH3_k127_11122833_2	1449126.JQKL01000035_gene2186	4.844e-34	133.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,268AK@186813|unclassified Clostridiales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
WLSH3_k127_11124594_3	1095738.HMPREF1047_1024	1.066e-05	55.0	COG2020@1|root,COG2020@2|Bacteria,1VF75@1239|Firmicutes,4HNPU@91061|Bacilli,1WQ1D@1303|Streptococcus oralis	91061|Bacilli	O	Ergosterol biosynthesis ERG4/ERG24 family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_11124594_0	647113.Metok_0186	2.37e-228	724.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
WLSH3_k127_11124594_2	374847.Kcr_0553	4.126e-21	101.0	COG0746@1|root,arCOG01872@2157|Archaea	2157|Archaea	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
WLSH3_k127_11124594_1	868131.MSWAN_0382	2.492e-60	214.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,23NRS@183925|Methanobacteria	183925|Methanobacteria	O	hydrogenase expression formation protein	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
WLSH3_k127_11129601_0	1274524.BSONL12_22790	7.135e-40	153.0	COG0454@1|root,COG0456@2|Bacteria,1VFVQ@1239|Firmicutes,4HK5T@91061|Bacilli,1ZIKN@1386|Bacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
WLSH3_k127_11136712_1	517418.Ctha_0236	1.983e-23	117.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	cspBA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
WLSH3_k127_11136712_3	693661.Arcve_1359	0.0001362	55.0	COG3291@1|root,COG3979@1|root,arCOG02499@1|root,arCOG02552@1|root,arCOG03439@1|root,arCOG02499@2157|Archaea,arCOG02552@2157|Archaea,arCOG03439@2157|Archaea,arCOG03504@2157|Archaea,arCOG07581@2157|Archaea,2XXWR@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
WLSH3_k127_11136712_0	265729.GS18_0221420	8.769e-131	426.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4HATT@91061|Bacilli,1ZB9N@1386|Bacillus	91061|Bacilli	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
WLSH3_k127_11136712_2	1519464.HY22_02330	3.023e-14	75.0	COG4198@1|root,COG4198@2|Bacteria,1FDIR@1090|Chlorobi	1090|Chlorobi	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
WLSH3_k127_11215250_1	439481.Aboo_1252	7.517e-71	248.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,3F38V@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	oppD2	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_11215250_0	867903.ThesuDRAFT_01078	3.537e-127	415.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WCUJ@538999|Clostridiales incertae sedis	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
WLSH3_k127_112211_1	523845.AQXV01000030_gene1331	1.659e-103	348.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,23QNZ@183939|Methanococci	183939|Methanococci	C	PFAM Amidohydrolase 3	fwdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
WLSH3_k127_112211_0	693661.Arcve_1113	2.022e-128	423.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,245WE@183980|Archaeoglobi	28890|Euryarchaeota	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
WLSH3_k127_112211_6	387631.Asulf_01598	1.661e-22	102.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,246AM@183980|Archaeoglobi	183980|Archaeoglobi	C	Formylmethanofuran dehydrogenase subunit D	-	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
WLSH3_k127_112211_2	387631.Asulf_00752	8.885e-87	297.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,24603@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
WLSH3_k127_112211_4	368407.Memar_0618	1.167e-48	185.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2N9RN@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	fwdC-1	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
WLSH3_k127_112211_3	426368.MmarC7_0438	2.017e-86	295.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,23Q6B@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
WLSH3_k127_112211_5	192952.MM_3157	1e-39	157.0	COG1680@1|root,arCOG00771@2157|Archaea	2157|Archaea	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1202	Beta-lactamase
WLSH3_k127_11221554_1	7176.CPIJ001069-PA	3.994e-05	54.0	COG4886@1|root,KOG0619@2759|Eukaryota,38GPY@33154|Opisthokonta,3BFMX@33208|Metazoa,3CS8Y@33213|Bilateria,41WIW@6656|Arthropoda,3SH2I@50557|Insecta,450MN@7147|Diptera,45CAJ@7148|Nematocera	33208|Metazoa	S	Leucine rich repeat C-terminal domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K17256	-	-	-	-	ko00000,ko04147	-	-	-	LRR_5,LRR_8
WLSH3_k127_11221554_0	1121272.KB903293_gene7124	1.075e-06	57.0	COG0330@1|root,COG0330@2|Bacteria,2IC5W@201174|Actinobacteria,4DIA5@85008|Micromonosporales	201174|Actinobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
WLSH3_k127_11232242_2	72228.T5AGU1	0.0001957	54.0	COG1204@1|root,KOG0952@2759|Eukaryota,38CPH@33154|Opisthokonta,3NYFN@4751|Fungi,3QP31@4890|Ascomycota,213N3@147550|Sordariomycetes,3TFJE@5125|Hypocreales	4751|Fungi	A	Activating signal cointegrator 1 complex subunit 3	mug81	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0006139,GO:0006412,GO:0006417,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010494,GO:0010501,GO:0010556,GO:0010608,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032268,GO:0032991,GO:0034248,GO:0034641,GO:0034645,GO:0035770,GO:0036464,GO:0042623,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0070013,GO:0070035,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0099053,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112	3.6.4.13	ko:K18664	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	DEAD,Helicase_C,Sec63
WLSH3_k127_11232242_1	273116.14324400	5.273e-24	110.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,241RM@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
WLSH3_k127_11232242_0	1104324.P186_2190	8.162e-67	235.0	COG1812@1|root,arCOG01678@2157|Archaea,2XPSB@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
WLSH3_k127_11266914_0	415426.Hbut_1425	8.57e-121	398.0	COG0060@1|root,arCOG00807@2157|Archaea,2XPWM@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
WLSH3_k127_11266914_1	290402.Cbei_2855	3.967e-12	73.0	COG4997@1|root,COG4997@2|Bacteria,1VEG6@1239|Firmicutes,24QRF@186801|Clostridia,36KRV@31979|Clostridiaceae	186801|Clostridia	S	phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF429,MazG-like
WLSH3_k127_11270353_5	1227497.C491_06923	3.485e-12	72.0	COG2402@1|root,arCOG04502@2157|Archaea,2XXE8@28890|Euryarchaeota,23VKJ@183963|Halobacteria	183963|Halobacteria	V	nucleic acid-binding protein, contains PIN domain	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
WLSH3_k127_11270353_0	740709.A10D4_12268	5.593e-77	286.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,1RP0R@1236|Gammaproteobacteria,2QFVM@267893|Idiomarinaceae	1236|Gammaproteobacteria	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WLSH3_k127_11270353_4	439481.Aboo_0134	3.236e-14	85.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_11270353_6	797299.HALLA_13430	2.598e-10	65.0	COG1846@1|root,arCOG00732@2157|Archaea,2XZ9E@28890|Euryarchaeota,23X3E@183963|Halobacteria	183963|Halobacteria	K	COG1846 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
WLSH3_k127_11270353_3	1220534.B655_2435	2.186e-25	120.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_11270353_1	693661.Arcve_1732	4.292e-60	216.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_11270353_2	572478.Vdis_1036	5.136e-31	130.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
WLSH3_k127_11271758_2	1158606.I579_01275	5.245e-06	57.0	COG3275@1|root,COG3275@2|Bacteria,1UM6J@1239|Firmicutes,4ITRS@91061|Bacilli,4B5ZS@81852|Enterococcaceae	91061|Bacilli	T	ECF transporter, substrate-specific component	-	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
WLSH3_k127_11271758_1	909663.KI867150_gene554	1.012e-26	119.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,43B10@68525|delta/epsilon subdivisions,2WRXZ@28221|Deltaproteobacteria,2MRDC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FdhD/NarQ family	-	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
WLSH3_k127_11316844_0	698769.JFBD01000030_gene1321	4.927e-17	94.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,4HAZA@91061|Bacilli,4C67S@84406|Virgibacillus	91061|Bacilli	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
WLSH3_k127_11318210_0	118173.KB235910_gene4790	1.028e-67	244.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
WLSH3_k127_11340808_1	565033.GACE_1903	2.798e-53	196.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
WLSH3_k127_11340808_0	1265505.ATUG01000002_gene1149	2.269e-65	239.0	COG2153@1|root,COG2516@1|root,COG2153@2|Bacteria,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,42NT3@68525|delta/epsilon subdivisions,2WJD8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Radical_SAM
WLSH3_k127_11351291_0	489825.LYNGBM3L_33260	6.594e-07	61.0	COG1131@1|root,COG1131@2|Bacteria,1GQKB@1117|Cyanobacteria	1117|Cyanobacteria	V	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
WLSH3_k127_11351291_2	522306.CAP2UW1_2485	0.0001589	49.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1RHVK@1224|Proteobacteria,2VT8V@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_8,Trypsin_2
WLSH3_k127_11351291_1	5759.rna_EHI_158150-1	3.911e-06	50.0	KOG1703@1|root,KOG1703@2759|Eukaryota,3XACX@554915|Amoebozoa	554915|Amoebozoa	TZ	Zinc-binding domain present in Lin-11, Isl-1, Mec-3.	-	-	-	-	-	-	-	-	-	-	-	-	LIM
WLSH3_k127_11352726_3	634497.HAH_2740	6.866e-19	90.0	COG1073@1|root,arCOG01649@2157|Archaea,2XW9X@28890|Euryarchaeota,23T03@183963|Halobacteria	183963|Halobacteria	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WLSH3_k127_11352726_0	515635.Dtur_0011	6.952e-42	158.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
WLSH3_k127_11352726_1	386456.JQKN01000001_gene2324	1.749e-35	144.0	arCOG02703@1|root,arCOG02703@2157|Archaea,2XY9N@28890|Euryarchaeota	28890|Euryarchaeota	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_11352726_2	525904.Tter_2199	5.247e-33	132.0	COG2227@1|root,COG2227@2|Bacteria,2NRF7@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
WLSH3_k127_11352726_4	67281.JNZZ01000008_gene5794	2.662e-12	68.0	COG1092@1|root,COG1092@2|Bacteria,2I33B@201174|Actinobacteria,417V2@629295|Streptomyces griseus group	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_11369514_0	215803.DB30_8551	4.016e-30	123.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WME2@28221|Deltaproteobacteria,2YWHE@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_11429495_4	1047013.AQSP01000144_gene916	7.735e-14	72.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
WLSH3_k127_11429495_1	1047013.AQSP01000144_gene917	4.275e-52	186.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,DrsE_2
WLSH3_k127_11429495_3	1047013.AQSP01000144_gene918	7.405e-28	114.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
WLSH3_k127_11429495_0	1459636.NTE_02779	1.472e-57	211.0	COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	tRNA methyl transferase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	QueC
WLSH3_k127_11429495_2	1380393.JHVP01000001_gene2524	4.007e-28	119.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4ES09@85013|Frankiales	201174|Actinobacteria	BQ	PFAM Histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
WLSH3_k127_11458027_0	523850.TON_1311	1.694e-42	163.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242YZ@183968|Thermococci	183968|Thermococci	C	Indolepyruvate ferredoxin oxidoreductase subunit	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
WLSH3_k127_11458027_1	338963.Pcar_2117	7.658e-08	55.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,43UAV@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-2	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
WLSH3_k127_11462444_1	153721.MYP_3343	6.886e-22	101.0	COG1246@1|root,COG1246@2|Bacteria,4NVX0@976|Bacteroidetes,47SE9@768503|Cytophagia	976|Bacteroidetes	E	Acetyltransferase (GNAT) domain	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
WLSH3_k127_11462444_2	118163.Ple7327_0421	5.659e-20	98.0	COG1522@1|root,COG1522@2|Bacteria,1G9VY@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_11462444_0	324602.Caur_3395	4.478e-96	329.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,37516@32061|Chloroflexia	32061|Chloroflexia	H	PFAM glutamine synthetase catalytic region	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
WLSH3_k127_1146744_1	562970.Btus_1631	6.349e-08	57.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes	1239|Firmicutes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
WLSH3_k127_1146744_0	574087.Acear_1487	4.613e-63	229.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_11480869_1	349161.Dred_2104	2.248e-51	188.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,2611K@186807|Peptococcaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
WLSH3_k127_11480869_0	373903.Hore_21550	7.858e-93	321.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3WA6K@53433|Halanaerobiales	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
WLSH3_k127_11480869_2	1123511.KB905841_gene1366	3.513e-21	102.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,4H2SY@909932|Negativicutes	909932|Negativicutes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
WLSH3_k127_11480869_3	5722.XP_001318896.1	1.279e-17	87.0	KOG0092@1|root,KOG0092@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ras
WLSH3_k127_11505899_3	572546.Arcpr_0713	4.304e-25	114.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
WLSH3_k127_11505899_1	38833.XP_003055430.1	4.563e-59	226.0	297V5@1|root,2REVD@2759|Eukaryota,389P5@33090|Viridiplantae,34IW7@3041|Chlorophyta	3041|Chlorophyta	S	WD repeat protein 35. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_11505899_2	296587.XP_002499438.1	9.668e-27	116.0	297V5@1|root,2REVD@2759|Eukaryota,389P5@33090|Viridiplantae,34IW7@3041|Chlorophyta	3041|Chlorophyta	S	WD repeat protein 35. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_11505899_0	1121468.AUBR01000024_gene3021	2.573e-161	525.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_11505899_4	768704.Desmer_0945	1.207e-24	110.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,262Q4@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
WLSH3_k127_11510433_2	234267.Acid_1768	5.038e-05	53.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria	57723|Acidobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
WLSH3_k127_11510433_0	357808.RoseRS_0179	2.95e-50	192.0	COG1136@1|root,COG2002@1|root,COG1136@2|Bacteria,COG2002@2|Bacteria,2G5S3@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
WLSH3_k127_11510433_3	1337936.IJ00_02420	0.0003818	52.0	COG4188@1|root,COG4188@2|Bacteria,1G2BZ@1117|Cyanobacteria,1HIU6@1161|Nostocales	1117|Cyanobacteria	S	PFAM Alpha beta hydrolase of	-	-	-	-	-	-	-	-	-	-	-	-	DUF1400,PAF-AH_p_II
WLSH3_k127_11510433_1	616991.JPOO01000003_gene1314	3.967e-05	55.0	COG4287@1|root,COG4287@2|Bacteria,4NI0U@976|Bacteroidetes,1I7JW@117743|Flavobacteriia,23G2C@178469|Arenibacter	976|Bacteroidetes	S	PhoPQ-activated pathogenicity-related protein	-	-	-	-	-	-	-	-	-	-	-	-	PhoPQ_related
WLSH3_k127_11518097_0	697303.Thewi_1720	6.975e-145	491.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
WLSH3_k127_11518103_1	662479.C440_13114	6.33e-29	121.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,23SY3@183963|Halobacteria	183963|Halobacteria	E	Belongs to the peptidase M24B family	pepQ	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_11518103_0	1184251.TCELL_1373	1.182e-105	354.0	COG0167@1|root,COG1143@1|root,arCOG00603@2157|Archaea,arCOG01543@2157|Archaea,2XQ06@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
WLSH3_k127_11518103_2	304371.MCP_0618	9.693e-18	87.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,2N9BJ@224756|Methanomicrobia	224756|Methanomicrobia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	aor-2	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_11536800_0	456442.Mboo_2448	2.374e-106	353.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,2N945@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM elongation factor Tu domain 2	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
WLSH3_k127_11536800_1	635013.TherJR_2384	5.309e-17	93.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,261S1@186807|Peptococcaceae	186801|Clostridia	T	Membrane-associated sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,Response_reg
WLSH3_k127_11565768_0	70601.3257835	1.829e-64	232.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,242V4@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_1179015_0	178306.PAE1503	1.047e-17	88.0	COG1257@1|root,arCOG05512@2157|Archaea,2XSJX@28889|Crenarchaeota	28889|Crenarchaeota	I	hydroxymethylglutaryl-CoA reductase (NADPH) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1179015_2	1944.JOAZ01000004_gene4832	1.69e-12	78.0	COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
WLSH3_k127_1179015_1	269797.Mbar_A0271	1.864e-17	87.0	COG0110@1|root,arCOG01850@2157|Archaea	2157|Archaea	S	COG0110 Acetyltransferase (isoleucine patch superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WLSH3_k127_1179015_3	1380394.JADL01000011_gene4097	1.164e-10	64.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP2	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
WLSH3_k127_1185137_3	262724.TT_C1877	2.493e-07	52.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1WKTT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	LV	Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase,TaqI_C
WLSH3_k127_1185137_0	593117.TGAM_0813	8.745e-85	289.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,242SX@183968|Thermococci	183968|Thermococci	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WLSH3_k127_1185137_4	648996.Theam_0161	5.522e-06	55.0	COG0457@1|root,COG0457@2|Bacteria,2G407@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
WLSH3_k127_1185137_1	591019.Shell_1440	5.98e-41	156.0	COG0185@1|root,arCOG04099@2157|Archaea,2XQBR@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
WLSH3_k127_1185137_2	693661.Arcve_0688	8.567e-08	58.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,245R2@183980|Archaeoglobi	183980|Archaeoglobi	L	Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
WLSH3_k127_1188411_1	706433.HMPREF9430_01036	1.501e-56	203.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,3VPVI@526524|Erysipelotrichia	526524|Erysipelotrichia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_1188411_2	679926.Mpet_0901	0.0001486	52.0	COG0640@1|root,arCOG00734@2157|Archaea,2XXHJ@28890|Euryarchaeota,2N9JR@224756|Methanomicrobia	224756|Methanomicrobia	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_1188411_0	1128421.JAGA01000002_gene776	8.251e-75	259.0	COG3342@1|root,COG3342@2|Bacteria,2NP87@2323|unclassified Bacteria	2|Bacteria	S	Family of unknown function (DUF1028)	fimA	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
WLSH3_k127_1193302_0	694429.Pyrfu_1605	1.451e-45	172.0	COG1676@1|root,arCOG01701@2157|Archaea,2XQJB@28889|Crenarchaeota	28889|Crenarchaeota	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
WLSH3_k127_1251383_0	795797.C497_18442	3.841e-100	353.0	COG1680@1|root,arCOG00771@2157|Archaea,2XTP8@28890|Euryarchaeota,23SW1@183963|Halobacteria	183963|Halobacteria	E	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WLSH3_k127_1251383_1	877455.Metbo_1530	5.04e-11	63.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
WLSH3_k127_1294384_0	1219084.AP014508_gene567	3.351e-148	480.0	COG0334@1|root,COG0334@2|Bacteria,2GCH4@200918|Thermotogae	200918|Thermotogae	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iLJ478.TM1015	ELFV_dehydrog,ELFV_dehydrog_N
WLSH3_k127_1294384_1	1304880.JAGB01000002_gene2276	4.805e-33	142.0	COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,24AYS@186801|Clostridia	186801|Clostridia	E	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
WLSH3_k127_1338392_0	593117.TGAM_0791	3.752e-88	300.0	COG2362@1|root,arCOG04080@2157|Archaea,2XVFH@28890|Euryarchaeota,243NH@183968|Thermococci	183968|Thermococci	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
WLSH3_k127_1338392_1	591019.Shell_0049	1.493e-22	107.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
WLSH3_k127_1347097_0	420247.Msm_1164	3.397e-112	375.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,23NMZ@183925|Methanobacteria	183925|Methanobacteria	J	PFAM GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
WLSH3_k127_1347097_2	633148.Tagg_0582	3.822e-18	86.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
WLSH3_k127_1347097_1	1132442.KB889752_gene1431	6.379e-36	139.0	COG4922@1|root,COG4922@2|Bacteria,1V6S2@1239|Firmicutes,4HJRI@91061|Bacilli,1ZGJ4@1386|Bacillus	91061|Bacilli	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
WLSH3_k127_1347097_3	69014.TK1339	6.166e-11	65.0	COG1476@1|root,arCOG01864@2157|Archaea,2XZS8@28890|Euryarchaeota,244GH@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
WLSH3_k127_1353076_4	1469613.JT55_01895	5.159e-76	263.0	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,2TTF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	divalent heavy-metal cations transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
WLSH3_k127_1353076_0	1120746.CCNL01000017_gene2767	5.238e-193	614.0	COG2368@1|root,COG2368@2|Bacteria	2|Bacteria	Q	4-hydroxyphenylacetate	abfD	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
WLSH3_k127_1353076_6	1274524.BSONL12_22790	1.547e-46	173.0	COG0454@1|root,COG0456@2|Bacteria,1VFVQ@1239|Firmicutes,4HK5T@91061|Bacilli,1ZIKN@1386|Bacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
WLSH3_k127_1353076_8	224325.AF_0799	8.34e-28	120.0	COG0622@1|root,arCOG01141@2157|Archaea,2XXVQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
WLSH3_k127_1353076_2	1041930.Mtc_1125	1.384e-116	404.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
WLSH3_k127_1353076_1	368408.Tpen_0817	9.105e-158	512.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WLSH3_k127_1353076_7	693661.Arcve_2003	5.552e-46	172.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,246YM@183980|Archaeoglobi	183980|Archaeoglobi	F	Nicotinamide-nucleotide adenylyltransferase	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
WLSH3_k127_1353076_3	453591.Igni_0532	5.584e-111	369.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
WLSH3_k127_1353076_5	673860.AciM339_0957	1.302e-51	189.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,3F2J9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Nucleolar GTP-binding protein 1 (NOG1)	gbp4	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
WLSH3_k127_1365702_1	439481.Aboo_0430	1.341e-17	93.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,3F2HE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,Rad51
WLSH3_k127_1365702_2	673860.AciM339_0411	6.785e-05	48.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y76C@28890|Euryarchaeota,3F3GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1365702_0	1313265.JNIE01000003_gene1420	1.607e-32	130.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
WLSH3_k127_1429708_6	742725.HMPREF9450_02267	7.388e-22	100.0	COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FNVV@200643|Bacteroidia,22U0H@171550|Rikenellaceae	976|Bacteroidetes	E	Peptidase family M20/M25/M40	pepD_1	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_1429708_4	1459636.NTE_01453	1.674e-41	163.0	arCOG05906@1|root,arCOG05906@2157|Archaea,41T21@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1429708_8	1292034.OR37_00904	3.463e-05	54.0	COG1432@1|root,COG1432@2|Bacteria,1R9SC@1224|Proteobacteria,2UBN5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
WLSH3_k127_1429708_5	1410668.JNKC01000006_gene678	1.962e-26	119.0	COG0671@1|root,COG0671@2|Bacteria,1V01Y@1239|Firmicutes,24DFI@186801|Clostridia,36VSV@31979|Clostridiaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
WLSH3_k127_1429708_3	797209.ZOD2009_14186	5.44e-44	173.0	COG1874@1|root,arCOG04085@2157|Archaea,2XSU6@28890|Euryarchaeota,23UX4@183963|Halobacteria	183963|Halobacteria	G	COG1874 Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1429708_7	595536.ADVE02000001_gene700	4.99e-16	87.0	COG4689@1|root,COG4689@2|Bacteria,1N4IP@1224|Proteobacteria,2TTZX@28211|Alphaproteobacteria,36ZB8@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	Acetoacetate decarboxylase (ADC)	adc	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
WLSH3_k127_1429708_0	479434.Sthe_2328	2.223e-70	246.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,27Z66@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_1429708_1	309801.trd_0142	1.586e-69	251.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
WLSH3_k127_1429708_2	1434325.AZQN01000001_gene456	4.717e-44	169.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
WLSH3_k127_1446101_1	375451.RD1_1062	8.495e-12	73.0	COG0406@1|root,COG0406@2|Bacteria,1R896@1224|Proteobacteria,2U4QW@28211|Alphaproteobacteria,2P4GU@2433|Roseobacter	28211|Alphaproteobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WLSH3_k127_1446101_0	760192.Halhy_5115	1.025e-23	102.0	2DBX9@1|root,2ZBN9@2|Bacteria,4NVAY@976|Bacteroidetes,1IZRN@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1448775_3	861299.J421_2443	6.689e-44	164.0	COG0177@1|root,COG0177@2|Bacteria,1ZT7K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
WLSH3_k127_1448775_0	351160.LRC224	2.481e-144	470.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,2NADB@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
WLSH3_k127_1448775_1	335543.Sfum_0163	5.671e-107	360.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,42NJ3@68525|delta/epsilon subdivisions,2WKHX@28221|Deltaproteobacteria,2MQTA@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
WLSH3_k127_1448775_2	642492.Clole_3287	1.199e-48	186.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,2489I@186801|Clostridia	186801|Clostridia	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
WLSH3_k127_1448775_4	237368.SCABRO_03297	1.185e-15	83.0	COG1633@1|root,COG1633@2|Bacteria,2J3U9@203682|Planctomycetes	203682|Planctomycetes	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WLSH3_k127_1448775_5	1304874.JAFY01000007_gene1682	4.988e-08	54.0	28IMC@1|root,2Z8MV@2|Bacteria,3T9Z4@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1464576_0	479433.Caci_5177	1.862e-08	66.0	COG5426@1|root,COG5426@2|Bacteria,2GKG4@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1470523_0	1286171.EAL2_c07480	1.596e-67	237.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia	186801|Clostridia	L	PFAM DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
WLSH3_k127_1470523_2	1343739.PAP_00865	1.28e-24	113.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota,2436Y@183968|Thermococci	183968|Thermococci	P	ABC-type cobalt transport system, permease	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
WLSH3_k127_1470523_1	368408.Tpen_0713	2.248e-27	116.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
WLSH3_k127_1483154_4	931277.C448_02301	5.037e-12	70.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,23W2K@183963|Halobacteria	183963|Halobacteria	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
WLSH3_k127_1483154_3	877455.Metbo_2394	8.156e-22	97.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,23P69@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
WLSH3_k127_1483154_2	186497.PF1562	1.779e-113	378.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,242U8@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
WLSH3_k127_1483154_0	415426.Hbut_1574	0.0	1069.0	COG0086@1|root,arCOG04257@2157|Archaea,2XPT5@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
WLSH3_k127_1483154_1	386456.JQKN01000001_gene2266	5.134e-172	547.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,23NMQ@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB1	-	2.7.7.6	ko:K03044,ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WLSH3_k127_1483253_2	1537715.JQFJ01000002_gene1740	3.05e-51	192.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VFDU@28211|Alphaproteobacteria,2K48Y@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WLSH3_k127_1483253_0	224325.AF_1299	1.242e-97	328.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_1483253_4	867903.ThesuDRAFT_01499	8.521e-28	121.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH3_k127_1483253_3	1382356.JQMP01000003_gene1377	7.941e-35	139.0	COG2110@1|root,COG2110@2|Bacteria,2G7ID@200795|Chloroflexi,27YKP@189775|Thermomicrobia	189775|Thermomicrobia	S	Macro domain	-	-	-	-	-	-	-	-	-	-	-	-	Macro
WLSH3_k127_1483253_1	272844.PAB1931	2.788e-86	304.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,24368@183968|Thermococci	183968|Thermococci	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
WLSH3_k127_1483253_5	439481.Aboo_0134	2.543e-11	75.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_1483253_6	439481.Aboo_0134	5.327e-09	68.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_1534793_4	402880.MmarC5_0561	4.291e-07	56.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
WLSH3_k127_1534793_0	529709.PYCH_16190	2.259e-305	974.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
WLSH3_k127_1534793_1	1220534.B655_0260	1.899e-52	195.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,23NXA@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
WLSH3_k127_1534793_2	529709.PYCH_18060	1.604e-40	156.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,243AW@183968|Thermococci	183968|Thermococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
WLSH3_k127_1534793_3	410358.Mlab_1272	2.132e-17	91.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
WLSH3_k127_1534793_5	926690.KE386573_gene1252	0.0002841	48.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,23SVJ@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1546049_1	1536773.R70331_05550	2.442e-41	169.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,26RFG@186822|Paenibacillaceae	91061|Bacilli	EGP	Permeases of the major facilitator superfamily	blt9	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,MFS_2,Sugar_tr
WLSH3_k127_1546049_0	694429.Pyrfu_0913	2.771e-72	252.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
WLSH3_k127_1550617_1	242159.ABO94162	1.544e-14	79.0	COG5133@1|root,KOG3381@2759|Eukaryota,37PIV@33090|Viridiplantae,34KIW@3041|Chlorophyta	3041|Chlorophyta	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
WLSH3_k127_1550617_0	713587.THITH_03660	3.489e-16	85.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1WYDP@135613|Chromatiales	135613|Chromatiales	K	Ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_1585321_5	386456.JQKN01000001_gene2130	6.594e-33	131.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,23NJT@183925|Methanobacteria	183925|Methanobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
WLSH3_k127_1585321_4	1293048.CBMB010000003_gene1453	6.111e-38	155.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23SW4@183963|Halobacteria	183963|Halobacteria	G	Belongs to the carbohydrate kinase PfkB family	suk	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
WLSH3_k127_1585321_0	477974.Daud_0343	1.202e-111	368.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,2608G@186807|Peptococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
WLSH3_k127_1585321_1	523850.TON_0592	2.115e-91	310.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
WLSH3_k127_1585321_10	1094980.Mpsy_0490	2.591e-06	56.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
WLSH3_k127_1585321_9	985053.VMUT_0912	2.997e-07	55.0	COG2157@1|root,arCOG04175@2157|Archaea	2157|Archaea	J	PFAM Ribosomal LX protein	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
WLSH3_k127_1585321_3	529709.PYCH_19060	9.582e-48	179.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,243II@183968|Thermococci	183968|Thermococci	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
WLSH3_k127_1585321_7	694440.JOMF01000008_gene942	9.68e-16	82.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,2N9YU@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL31 family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
WLSH3_k127_1585321_8	768679.TTX_0584a	1.108e-07	54.0	COG2167@1|root,arCOG04177@2157|Archaea,2XRC0@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
WLSH3_k127_1585321_6	269797.Mbar_A0455	1.303e-22	103.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
WLSH3_k127_1585321_2	1220534.B655_1848	4.816e-52	188.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,23NZM@183925|Methanobacteria	183925|Methanobacteria	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
WLSH3_k127_161122_2	1321779.HMPREF1984_01423	3.024e-15	88.0	COG1744@1|root,COG1744@2|Bacteria,37BXP@32066|Fusobacteria	32066|Fusobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
WLSH3_k127_161122_0	1042877.GQS_09645	6.351e-25	112.0	COG1896@1|root,arCOG04311@2157|Archaea,2XX7G@28890|Euryarchaeota,2440T@183968|Thermococci	183968|Thermococci	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
WLSH3_k127_161122_1	1365176.N186_02145	1.207e-15	79.0	COG1628@1|root,arCOG00928@2157|Archaea	2157|Archaea	S	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
WLSH3_k127_1640536_7	1094508.Tsac_0964	3.592e-07	53.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,42EY1@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_1640536_2	224325.AF_1588	4.764e-30	134.0	COG1748@1|root,arCOG00243@2157|Archaea,2Y08S@28890|Euryarchaeota	28890|Euryarchaeota	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
WLSH3_k127_1640536_3	1175306.GWL_11510	1.398e-29	128.0	COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria	1224|Proteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
WLSH3_k127_1640536_6	1184607.AUCHE_03_01480	1.446e-07	62.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4F792@85018|Dermatophilaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_1640536_1	316274.Haur_1012	4.894e-51	194.0	COG0454@1|root,COG1246@1|root,COG0456@2|Bacteria,COG1246@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_1640536_0	1459636.NTE_00463	2.234e-62	225.0	COG3177@1|root,arCOG03112@2157|Archaea	2157|Archaea	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
WLSH3_k127_1640536_4	543526.Htur_5235	4.308e-18	95.0	arCOG04518@1|root,arCOG04518@2157|Archaea,2XUD7@28890|Euryarchaeota,23SZS@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
WLSH3_k127_1640536_5	1210908.HSB1_43770	2.844e-13	74.0	arCOG04041@1|root,arCOG04041@2157|Archaea,arCOG07592@2157|Archaea,2XV04@28890|Euryarchaeota,23U4R@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1656363_1	765420.OSCT_2237	7.543e-25	115.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_1656363_2	1304874.JAFY01000002_gene95	0.0002006	48.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3TAX3@508458|Synergistetes	508458|Synergistetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_16
WLSH3_k127_1656363_0	548477.HMPREF0294_0332	1.356e-56	228.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
WLSH3_k127_1671778_2	323259.Mhun_0020	5.858e-25	108.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
WLSH3_k127_1671778_0	647113.Metok_0171	4.915e-55	210.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23QR0@183939|Methanococci	183939|Methanococci	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
WLSH3_k127_1671778_1	880072.Desac_2171	1.377e-29	126.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
WLSH3_k127_1674527_0	633148.Tagg_0698	4.259e-81	277.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_1674527_1	1231241.Mc24_05805	9.155e-67	238.0	COG1173@1|root,COG1173@2|Bacteria,2GCC1@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_1674527_2	521045.Kole_2047	1.099e-65	236.0	COG0601@1|root,COG0601@2|Bacteria,2GBYF@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_1674527_4	935840.JAEQ01000009_gene1364	2.333e-41	169.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,43JPS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
WLSH3_k127_1674527_3	479435.Kfla_0284	2.907e-63	228.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
WLSH3_k127_1674527_5	304371.MCP_1481	6.757e-21	102.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1676549_0	867845.KI911784_gene975	3.243e-91	327.0	COG1132@1|root,COG1132@2|Bacteria,2G63W@200795|Chloroflexi,377YS@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_1676549_1	316274.Haur_2748	2.884e-06	50.0	COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi,3758C@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_1677357_0	930945.SiRe_1785	4.168e-39	153.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_1677357_1	765177.Desmu_0009	3.703e-32	132.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
WLSH3_k127_1697486_3	1292035.H476_2231	0.0004039	53.0	2BW99@1|root,2Z7PD@2|Bacteria,1TQFA@1239|Firmicutes,249NB@186801|Clostridia,25R27@186804|Peptostreptococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1697486_2	373903.Hore_10880	1.784e-39	159.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,3WAN3@53433|Halanaerobiales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01704,ko:K20453	ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R10170	RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
WLSH3_k127_1697486_0	1313265.JNIE01000002_gene833	5.343e-128	422.0	COG0065@1|root,COG0065@2|Bacteria,2G3S3@200783|Aquificae	200783|Aquificae	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
WLSH3_k127_1697486_1	1121946.AUAX01000021_gene8088	1.668e-103	349.0	COG0473@1|root,COG0473@2|Bacteria,2I8V7@201174|Actinobacteria	201174|Actinobacteria	CE	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
WLSH3_k127_1700800_0	195522.BD01_2007	4.639e-65	232.0	COG0388@1|root,arCOG00062@2157|Archaea,2XVVK@28890|Euryarchaeota,242PM@183968|Thermococci	183968|Thermococci	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
WLSH3_k127_1700800_1	1365176.N186_04695	4.286e-35	144.0	COG1515@1|root,arCOG00929@2157|Archaea,2XQNE@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
WLSH3_k127_1700800_2	926550.CLDAP_26550	1.842e-30	126.0	COG1136@1|root,COG1136@2|Bacteria,2G5S3@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
WLSH3_k127_1738906_1	868131.MSWAN_2168	8.403e-154	498.0	COG2303@1|root,arCOG02232@2157|Archaea,2Y89C@28890|Euryarchaeota,23NTI@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Glucose-methanol-choline oxidoreductase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_N
WLSH3_k127_1738906_3	868131.MSWAN_2167	1.071e-44	169.0	arCOG08232@1|root,arCOG08232@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_1738906_0	509191.AEDB02000076_gene1445	7.283e-296	934.0	COG1022@1|root,COG3320@1|root,COG1022@2|Bacteria,COG3320@2|Bacteria,1UVSP@1239|Firmicutes,24XTK@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
WLSH3_k127_1738906_2	868131.MSWAN_2165	7.074e-126	415.0	COG2327@1|root,arCOG04826@2157|Archaea	2157|Archaea	S	PFAM Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
WLSH3_k127_1787715_0	56780.SYN_00402	4.971e-68	233.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2MQYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
WLSH3_k127_1787715_1	28532.XP_010556200.1	4.09e-07	62.0	KOG4155@1|root,KOG4155@2759|Eukaryota,37MNG@33090|Viridiplantae,3GC1A@35493|Streptophyta,3HP5F@3699|Brassicales	35493|Streptophyta	S	Transducin family protein WD-40 repeat family	-	GO:0000166,GO:0000278,GO:0000281,GO:0000910,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004683,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005826,GO:0005856,GO:0005938,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007010,GO:0007049,GO:0008092,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0015629,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016905,GO:0017022,GO:0017076,GO:0018107,GO:0018193,GO:0018210,GO:0019538,GO:0022402,GO:0022411,GO:0030029,GO:0030036,GO:0030554,GO:0030863,GO:0030864,GO:0031033,GO:0031035,GO:0031037,GO:0031038,GO:0032153,GO:0032155,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044464,GO:0045159,GO:0046777,GO:0051301,GO:0061640,GO:0070938,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0099568,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1903047	-	-	-	-	-	-	-	-	-	-	WD40
WLSH3_k127_1787715_2	593750.Metfor_2784	2.145e-06	53.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
WLSH3_k127_1792239_1	930945.SiRe_2131	6.224e-30	125.0	COG0596@1|root,arCOG01648@2157|Archaea	2157|Archaea	IQ	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
WLSH3_k127_1792239_0	1118054.CAGW01000024_gene451	4.27e-91	316.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,26SYE@186822|Paenibacillaceae	91061|Bacilli	E	peptidase M20	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_1800097_1	6500.XP_005104223.1	1.748e-05	56.0	KOG3760@1|root,KOG3760@2759|Eukaryota,39RZQ@33154|Opisthokonta,3BAMU@33208|Metazoa,3CV57@33213|Bilateria	33208|Metazoa	G	heparosan-N-sulfate-glucuronate 5-epimerase activity	GLCE	GO:0000139,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0006022,GO:0006023,GO:0006024,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0015012,GO:0015015,GO:0016020,GO:0016853,GO:0016854,GO:0016857,GO:0019538,GO:0030166,GO:0030201,GO:0030202,GO:0030203,GO:0030210,GO:0030334,GO:0031090,GO:0031984,GO:0032879,GO:0034645,GO:0040008,GO:0040012,GO:0040014,GO:0040018,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045927,GO:0046983,GO:0047464,GO:0048518,GO:0048638,GO:0048639,GO:0050379,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051239,GO:0051240,GO:0051270,GO:0065007,GO:0071704,GO:0098588,GO:0098791,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903510,GO:2000145	5.1.3.17	ko:K01793	ko00534,ko01100,map00534,map01100	M00059	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	C5-epim_C
WLSH3_k127_1800097_0	545264.KB898744_gene2185	4.017e-19	99.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RYBJ@1236|Gammaproteobacteria,1WX72@135613|Chromatiales	135613|Chromatiales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
WLSH3_k127_1810950_2	903818.KI912268_gene1371	4.868e-19	95.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_1810950_0	186497.PF1631	1.112e-90	314.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y2ZW@28890|Euryarchaeota,245AV@183968|Thermococci	183968|Thermococci	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
WLSH3_k127_1810950_1	1499967.BAYZ01000154_gene1533	2.158e-51	191.0	COG0084@1|root,COG0084@2|Bacteria,2NP9H@2323|unclassified Bacteria	2|Bacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WLSH3_k127_1810950_3	411902.CLOBOL_06569	3.471e-08	63.0	COG2159@1|root,COG2159@2|Bacteria,1VI8M@1239|Firmicutes	1239|Firmicutes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
WLSH3_k127_1837530_2	694429.Pyrfu_1962	9.166e-07	57.0	COG1340@1|root,arCOG01159@2157|Archaea,2XQW7@28889|Crenarchaeota	28889|Crenarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1837530_1	395964.KE386496_gene3265	1.929e-27	123.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,3NAF4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	HJ	RimK-like ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
WLSH3_k127_1837530_0	416591.Tlet_1486	4.85e-80	280.0	COG0449@1|root,COG0449@2|Bacteria,2GBY1@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
WLSH3_k127_184969_0	215803.DB30_4984	0.0006581	50.0	COG1404@1|root,COG3509@1|root,COG1404@2|Bacteria,COG3509@2|Bacteria,1Q2N6@1224|Proteobacteria,4388Y@68525|delta/epsilon subdivisions,2X3IJ@28221|Deltaproteobacteria,2YW8H@29|Myxococcales	28221|Deltaproteobacteria	OQ	depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1851934_0	521045.Kole_2071	4.381e-69	246.0	COG0078@1|root,COG0078@2|Bacteria,2GCNA@200918|Thermotogae	200918|Thermotogae	E	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
WLSH3_k127_1851934_1	644966.Tmar_0906	6.939e-09	58.0	COG5012@1|root,COG5012@2|Bacteria,1UZP9@1239|Firmicutes,24CTM@186801|Clostridia	186801|Clostridia	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Met_asp_mut_E
WLSH3_k127_1871028_1	1385514.N782_16415	6.094e-24	110.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,2Y9R6@289201|Pontibacillus	91061|Bacilli	EP	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
WLSH3_k127_1871028_2	70601.3257075	1.081e-14	87.0	COG0477@1|root,arCOG00130@2157|Archaea,2XT83@28890|Euryarchaeota,242PX@183968|Thermococci	183968|Thermococci	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_1871028_0	269799.Gmet_2664	4.908e-99	334.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
WLSH3_k127_1880502_2	32057.KB217483_gene9280	2.348e-08	63.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,1HKH8@1161|Nostocales	1117|Cyanobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_1880502_0	45351.EDO43129	1.52e-32	133.0	KOG0084@1|root,KOG0084@2759|Eukaryota,38DXZ@33154|Opisthokonta,3BEKS@33208|Metazoa	2759|Eukaryota	U	GTPase activity	-	-	-	ko:K07874,ko:K07910,ko:K07930	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_1880502_1	1365176.N186_08905	6.545e-24	106.0	COG0265@1|root,arCOG02833@2157|Archaea,2XQ4X@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WLSH3_k127_1946381_0	1150626.PHAMO_210126	8.93e-24	109.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,2JPJ6@204441|Rhodospirillales	204441|Rhodospirillales	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15,Peptidase_S9
WLSH3_k127_1946381_1	1539298.JO41_09115	3.97e-14	81.0	COG0546@1|root,COG0546@2|Bacteria,2J7K0@203691|Spirochaetes	203691|Spirochaetes	S	Phosphoglycolate phosphatase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
WLSH3_k127_1958037_0	579137.Metvu_1133	3.139e-94	318.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,23Q29@183939|Methanococci	183939|Methanococci	S	Methanogenesis marker protein 14	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
WLSH3_k127_1958037_1	877455.Metbo_0361	1.231e-87	299.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
WLSH3_k127_1958037_4	877455.Metbo_0358	6.291e-42	162.0	COG4063@1|root,arCOG03221@2157|Archaea,2XWSE@28890|Euryarchaeota,23PC8@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrA	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
WLSH3_k127_1958037_3	386456.JQKN01000013_gene3042	6.015e-57	212.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
WLSH3_k127_1958037_2	795359.TOPB45_0396	2.304e-84	289.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	metF3	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
WLSH3_k127_1958037_5	1304875.JAFZ01000001_gene971	4.433e-10	69.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_1965086_0	572546.Arcpr_0509	5.409e-65	229.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,246RW@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
WLSH3_k127_1965086_2	439481.Aboo_0184	4.382e-55	201.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,3F2JN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
WLSH3_k127_1965086_1	868131.MSWAN_0460	2.913e-55	203.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,23P36@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
WLSH3_k127_1977529_0	572547.Amico_1777	4.932e-37	160.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_1986093_1	1114922.CIFAM_06_04810	1.668e-08	66.0	COG2211@1|root,COG2211@2|Bacteria,1RCS5@1224|Proteobacteria	1224|Proteobacteria	G	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_1986093_2	679926.Mpet_2740	0.0001728	51.0	COG2881@1|root,arCOG03630@2157|Archaea,2XYDD@28890|Euryarchaeota,2NBAT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
WLSH3_k127_1986093_0	1121468.AUBR01000040_gene1735	1.034e-47	182.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,42GWN@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ family	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
WLSH3_k127_1998328_0	34506.g2926	1.477e-07	66.0	COG5069@1|root,KOG0255@1|root,KOG0255@2759|Eukaryota,KOG0518@2759|Eukaryota	2759|Eukaryota	Z	regulation of membrane repolarization during atrial cardiac muscle cell action potential	FLM	-	-	ko:K04437,ko:K06572	ko04010,ko04360,ko04510,ko05132,ko05205,map04010,map04360,map04510,map05132,map05205	-	-	-	ko00000,ko00001,ko04090,ko04147,ko04812	-	-	-	CH,Calx-beta,Filamin,MFS_1,PA14,REJ
WLSH3_k127_2018012_3	1365176.N186_03930	1.793e-07	57.0	arCOG04275@1|root,arCOG04275@2157|Archaea,2XR2U@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2018012_2	339860.Msp_1534	2.451e-38	147.0	COG1051@1|root,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,23PWZ@183925|Methanobacteria	183925|Methanobacteria	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH3_k127_2018012_1	1131266.ARWQ01000018_gene777	4.951e-42	166.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
WLSH3_k127_2018012_0	374847.Kcr_0092	4.136e-128	423.0	COG1167@1|root,arCOG00492@2157|Archaea	2157|Archaea	EK	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
WLSH3_k127_2018012_4	1278073.MYSTI_06771	3.937e-05	55.0	COG4365@1|root,COG4365@2|Bacteria	2|Bacteria	S	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
WLSH3_k127_201939_2	1304885.AUEY01000031_gene43	0.0006232	49.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,42MHJ@68525|delta/epsilon subdivisions,2WM6S@28221|Deltaproteobacteria,2MJJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	NGG1p interacting factor 3	-	-	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	NIF3
WLSH3_k127_201939_0	573064.Mefer_0477	7.211e-55	204.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23QKP@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
WLSH3_k127_201939_1	272844.PAB1208	8.105e-15	75.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
WLSH3_k127_2046370_0	552811.Dehly_0080	4.804e-121	396.0	COG0863@1|root,COG0863@2|Bacteria,2GB0Z@200795|Chloroflexi,34DQC@301297|Dehalococcoidia	301297|Dehalococcoidia	H	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
WLSH3_k127_2046370_3	1457250.BBMO01000001_gene1816	3.121e-20	104.0	COG0642@1|root,arCOG02359@1|root,arCOG02359@2157|Archaea,arCOG06408@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	2.7.13.3	ko:K02486,ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02022,ko03032	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,PAS,PAS_3,PAS_4,PAS_9
WLSH3_k127_2046370_2	177439.DP0065	7.356e-28	121.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42QX3@68525|delta/epsilon subdivisions,2WPC7@28221|Deltaproteobacteria,2MJMP@213118|Desulfobacterales	28221|Deltaproteobacteria	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_2046370_1	269797.Mbar_A2503	1.679e-69	243.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
WLSH3_k127_2069827_4	1379281.AVAG01000012_gene1479	1.476e-13	73.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,42RG2@68525|delta/epsilon subdivisions,2WNG4@28221|Deltaproteobacteria,2M9EE@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,Oxidored_q6
WLSH3_k127_2069827_2	429009.Adeg_2015	1.192e-52	189.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
WLSH3_k127_2069827_5	1365176.N186_05875	7.778e-07	53.0	COG1522@1|root,arCOG01117@2157|Archaea,2XRE6@28889|Crenarchaeota	28889|Crenarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
WLSH3_k127_2069827_0	574087.Acear_1487	1.441e-143	477.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_2069827_3	565033.GACE_0774	9.157e-28	118.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
WLSH3_k127_2069827_1	490899.DKAM_0625	1.024e-87	304.0	COG0044@1|root,arCOG00689@2157|Archaea,2XQ3G@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
WLSH3_k127_2107550_1	368407.Memar_1710	8.899e-28	123.0	COG0571@1|root,arCOG03457@2157|Archaea	368407.Memar_1710|-	K	PFAM Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2107550_0	195522.BD01_0598	1.664e-46	187.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2433G@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_2115408_0	374847.Kcr_0638	3.276e-29	130.0	arCOG02559@1|root,arCOG02559@2157|Archaea	2157|Archaea	P	by modhmm	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
WLSH3_k127_2118192_1	439235.Dalk_0164	1.479e-26	110.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
WLSH3_k127_2118192_0	439235.Dalk_0163	9.264e-88	300.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_2118192_2	439235.Dalk_0162	1.705e-12	78.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
WLSH3_k127_2137124_1	673860.AciM339_0799	4.04e-05	55.0	arCOG08669@1|root,arCOG08669@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
WLSH3_k127_2137124_0	368407.Memar_1605	1.992e-78	276.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,2NANE@224756|Methanomicrobia	224756|Methanomicrobia	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
WLSH3_k127_2144660_1	555079.Toce_0231	5.908e-91	313.0	COG0240@1|root,COG0240@2|Bacteria,1TUSI@1239|Firmicutes,249QW@186801|Clostridia,42FJR@68295|Thermoanaerobacterales	186801|Clostridia	C	NAD NADP octopine nopaline	odh	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	ApbA,NAD_Gly3P_dh_N,NAD_binding_2,Octopine_DH
WLSH3_k127_2144660_0	555079.Toce_0232	2.789e-174	561.0	COG5012@1|root,COG5012@2|Bacteria,1UZP9@1239|Firmicutes,24CTM@186801|Clostridia,42FUE@68295|Thermoanaerobacterales	186801|Clostridia	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Met_asp_mut_E
WLSH3_k127_2151559_0	6334.EFV53547	2.426e-08	66.0	KOG0092@1|root,KOG0092@2759|Eukaryota,3A22T@33154|Opisthokonta,3BQZZ@33208|Metazoa,3D6BU@33213|Bilateria	33208|Metazoa	U	GTP binding. It is involved in the biological process described with protein transport	-	GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0006810,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007422,GO:0008150,GO:0009987,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0023052,GO:0031982,GO:0032482,GO:0032501,GO:0032502,GO:0035556,GO:0043226,GO:0043227,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0065007	-	ko:K07890	-	-	-	-	ko00000,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_2155285_2	1183377.Py04_1216	1.482e-60	217.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,242SN@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_2155285_4	1123075.AUDP01000022_gene3586	2.962e-08	61.0	299ND@1|root,2ZWQQ@2|Bacteria,1UZ92@1239|Firmicutes,259QM@186801|Clostridia,3WQHW@541000|Ruminococcaceae	186801|Clostridia	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_2155285_3	1168059.KB899087_gene4088	1.188e-30	129.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria,3F064@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Aldolase/RraA	-	-	4.1.3.17	ko:K02553,ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000,ko03019	-	-	-	RraA-like
WLSH3_k127_2155285_1	656519.Halsa_1020	4.064e-81	284.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,25N8F@186801|Clostridia,3WBM2@53433|Halanaerobiales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
WLSH3_k127_2155285_0	768710.DesyoDRAFT_1953	4.103e-101	347.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
WLSH3_k127_2160699_1	384616.Pisl_0204	3.169e-05	54.0	COG2220@1|root,arCOG00530@2157|Archaea,2XS9U@28889|Crenarchaeota	28889|Crenarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
WLSH3_k127_2160699_2	278957.ABEA03000106_gene1797	0.0009238	52.0	COG1361@1|root,COG1361@2|Bacteria,46XYW@74201|Verrucomicrobia,3K8N4@414999|Opitutae	414999|Opitutae	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
WLSH3_k127_2160699_0	269797.Mbar_A2034	3.869e-09	62.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,2NB8N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2206124_0	1232428.CAVO010000037_gene1204	1.914e-05	57.0	COG0433@1|root,COG0433@2|Bacteria,1TQPR@1239|Firmicutes,4H7RY@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function DUF87	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2217450_0	589924.Ferp_2404	2.615e-70	246.0	arCOG03850@1|root,arCOG03850@2157|Archaea,2XYUB@28890|Euryarchaeota	28890|Euryarchaeota	S	Cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
WLSH3_k127_2217450_1	930945.SiRe_1932	1.46e-57	212.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
WLSH3_k127_2226431_0	565033.GACE_0763	1.305e-86	299.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,246UD@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
WLSH3_k127_2258056_3	693661.Arcve_1623	3.238e-40	155.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,24719@183980|Archaeoglobi	183980|Archaeoglobi	H	Involved in the catabolism of quinolinic acid (QA)	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
WLSH3_k127_2258056_2	1343739.PAP_06535	2.073e-59	212.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
WLSH3_k127_2258056_1	1220534.B655_0054	2.373e-64	237.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,23NQR@183925|Methanobacteria	183925|Methanobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
WLSH3_k127_2258056_5	304371.MCP_0296	3.637e-13	79.0	COG0517@1|root,arCOG00600@2157|Archaea,2XXMJ@28890|Euryarchaeota,2N9JW@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
WLSH3_k127_2258056_4	192952.MM_1301	3.417e-33	135.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
WLSH3_k127_2258056_0	604354.TSIB_1121	8.468e-124	422.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
WLSH3_k127_2258056_6	186497.PF0864	5.427e-13	75.0	COG1522@1|root,arCOG01585@2157|Archaea,2Y2M7@28890|Euryarchaeota,24476@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_2333349_3	203908.EGG01441	3.108e-07	63.0	COG5029@1|root,KOG0366@2759|Eukaryota,38DTQ@33154|Opisthokonta,3NTZW@4751|Fungi,3UZ5B@5204|Basidiomycota,2YCKM@29000|Pucciniomycotina	4751|Fungi	O	Prenyltransferase and squalene oxidase repeat	BET2	GO:0003674,GO:0003824,GO:0004659,GO:0004661,GO:0004663,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005968,GO:0006464,GO:0006605,GO:0006612,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0008104,GO:0008150,GO:0008152,GO:0008270,GO:0008318,GO:0009987,GO:0015031,GO:0015833,GO:0016192,GO:0016740,GO:0016765,GO:0017016,GO:0017137,GO:0018342,GO:0018344,GO:0019538,GO:0019899,GO:0031267,GO:0032991,GO:0033036,GO:0034613,GO:0036211,GO:0042886,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046872,GO:0046907,GO:0046914,GO:0048193,GO:0051020,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0072657,GO:0072659,GO:0090150,GO:0097354,GO:0140096,GO:1901564,GO:1902494,GO:1990234,GO:1990778	2.5.1.60	ko:K05956	-	-	-	-	ko00000,ko01000,ko01006,ko04131	-	-	-	Prenyltrans
WLSH3_k127_2333349_0	589924.Ferp_2549	1.743e-85	293.0	COG0492@1|root,arCOG01296@2157|Archaea,2XTJW@28890|Euryarchaeota,24639@183980|Archaeoglobi	183980|Archaeoglobi	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WLSH3_k127_2333349_2	273057.SSO2257	1.109e-11	75.0	COG4028@1|root,arCOG04328@2157|Archaea,2XQGW@28889|Crenarchaeota	28889|Crenarchaeota	S	P-loop ATPase GTPase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2333349_1	673860.AciM339_1242	1.025e-12	69.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2WH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
WLSH3_k127_2360894_0	1343739.PAP_07055	6.505e-32	131.0	COG2039@1|root,arCOG05850@2157|Archaea,2XWYT@28890|Euryarchaeota,2435Y@183968|Thermococci	183968|Thermococci	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
WLSH3_k127_2360894_1	269797.Mbar_A1393	4.659e-13	78.0	COG1280@1|root,arCOG01947@2157|Archaea,2XY47@28890|Euryarchaeota,2N9SP@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
WLSH3_k127_2365752_0	69014.TK0524	1.625e-24	103.0	COG1773@1|root,arCOG04391@2157|Archaea,2Y080@28890|Euryarchaeota,244NA@183968|Thermococci	183968|Thermococci	C	Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
WLSH3_k127_2365752_1	1108045.GORHZ_121_00380	8.056e-05	55.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4GAND@85026|Gordoniaceae	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_2387573_6	1056495.Calag_0306	5.492e-06	49.0	COG0022@1|root,COG1071@1|root,arCOG01052@2157|Archaea,arCOG01054@2157|Archaea,2XQ1Y@28889|Crenarchaeota	28889|Crenarchaeota	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
WLSH3_k127_2387573_0	171693.BN988_02044	1.128e-118	389.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,23MTG@182709|Oceanobacillus	91061|Bacilli	C	Transketolase, pyrimidine binding domain	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
WLSH3_k127_2387573_1	1347087.CBYO010000016_gene2564	8.771e-87	302.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,4HDFT@91061|Bacilli	91061|Bacilli	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
WLSH3_k127_2387573_2	1042877.GQS_06330	4.525e-31	132.0	COG0095@1|root,arCOG01939@2157|Archaea,2XUJ0@28890|Euryarchaeota,2451A@183968|Thermococci	183968|Thermococci	H	Biotin/lipoate A/B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
WLSH3_k127_2387573_3	760568.Desku_0323	4.076e-23	102.0	COG0599@1|root,COG0599@2|Bacteria,1VFY0@1239|Firmicutes,25CIE@186801|Clostridia,2631D@186807|Peptococcaceae	186801|Clostridia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
WLSH3_k127_2387573_4	411460.RUMTOR_00808	1.063e-17	86.0	COG1063@1|root,COG1063@2|Bacteria,1UUV0@1239|Firmicutes,25MAN@186801|Clostridia,3Y1TA@572511|Blautia	186801|Clostridia	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_2462475_0	521045.Kole_0522	3.025e-48	191.0	COG3345@1|root,COG3345@2|Bacteria,2GC20@200918|Thermotogae	200918|Thermotogae	G	Melibiase	-	GO:0003674,GO:0003824,GO:0004553,GO:0004557,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0009056,GO:0015925,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0042802,GO:0042803,GO:0046983,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
WLSH3_k127_2462475_1	931276.Cspa_c31080	1.605e-25	114.0	COG0457@1|root,COG0457@2|Bacteria,1UYZH@1239|Firmicutes,24BU9@186801|Clostridia,36F2E@31979|Clostridiaceae	186801|Clostridia	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
WLSH3_k127_2462698_0	604354.TSIB_0244	2.386e-44	170.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,243H9@183968|Thermococci	183968|Thermococci	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
WLSH3_k127_2462698_1	1041930.Mtc_0765	5.006e-15	78.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
WLSH3_k127_246622_10	768672.Desfe_1442	2.508e-13	75.0	COG1412@1|root,arCOG04312@2157|Archaea,2XR40@28889|Crenarchaeota	28889|Crenarchaeota	V	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1,PIN
WLSH3_k127_246622_0	647113.Metok_0259	1.609e-155	500.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
WLSH3_k127_246622_9	579137.Metvu_0814	1.044e-31	127.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23R2F@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
WLSH3_k127_246622_8	272844.PAB2195	9.19e-44	176.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
WLSH3_k127_246622_4	342949.PNA2_0268	4.937e-74	260.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
WLSH3_k127_246622_6	1343739.PAP_08120	1.624e-61	219.0	COG2413@1|root,arCOG04066@2157|Archaea,2XSZH@28890|Euryarchaeota,24347@183968|Thermococci	183968|Thermococci	S	Nucleotidyltransferase domain	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
WLSH3_k127_246622_3	673860.AciM339_0294	1.685e-79	279.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
WLSH3_k127_246622_5	269797.Mbar_A1576	4.848e-67	241.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,2N91R@224756|Methanomicrobia	224756|Methanomicrobia	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
WLSH3_k127_246622_2	673860.AciM339_1562	7.133e-109	370.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,3F2HJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	AAA domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
WLSH3_k127_246622_1	186497.PF1725	1.53e-109	368.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
WLSH3_k127_246622_7	523850.TON_0362	6.926e-49	182.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WLSH3_k127_2490088_5	1219084.AP014508_gene1357	7.808e-12	70.0	COG2006@1|root,COG2006@2|Bacteria,2GDWM@200918|Thermotogae	200918|Thermotogae	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
WLSH3_k127_2490088_1	269797.Mbar_A1406	7.17e-51	192.0	COG0382@1|root,arCOG00478@2157|Archaea,2Y84D@28890|Euryarchaeota	2157|Archaea	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
WLSH3_k127_2490088_2	1041930.Mtc_1980	9.507e-30	126.0	COG0613@1|root,arCOG00302@2157|Archaea,2XT0K@28890|Euryarchaeota,2NAUQ@224756|Methanomicrobia	224756|Methanomicrobia	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
WLSH3_k127_2490088_3	1382306.JNIM01000001_gene724	1.553e-25	114.0	COG0392@1|root,COG0392@2|Bacteria,2G6EN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
WLSH3_k127_2490088_4	391625.PPSIR1_32362	4.33e-13	75.0	COG0392@1|root,COG0392@2|Bacteria,1R4IS@1224|Proteobacteria,42WRK@68525|delta/epsilon subdivisions,2WSAB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
WLSH3_k127_2490088_0	1457250.BBMO01000001_gene657	4.583e-53	194.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,23RZH@183963|Halobacteria	183963|Halobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
WLSH3_k127_2491566_0	1122176.KB903609_gene5261	1.346e-24	113.0	COG1030@1|root,COG1030@2|Bacteria,4PN0T@976|Bacteroidetes,1ITG9@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
WLSH3_k127_2515114_0	673860.AciM339_1459	9.698e-176	563.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2FS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
WLSH3_k127_2537033_0	349163.Acry_1060	3.438e-05	51.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_11,TPR_16,TPR_2,TPR_8
WLSH3_k127_2543077_1	453591.Igni_1108	2.259e-45	174.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
WLSH3_k127_2543077_0	555079.Toce_2248	1.438e-121	406.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,42FKX@68295|Thermoanaerobacterales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
WLSH3_k127_2543077_2	181119.XP_005531554.1	2.839e-28	121.0	KOG0080@1|root,KOG0080@2759|Eukaryota,3AHG8@33154|Opisthokonta,3BX48@33208|Metazoa,3DDHH@33213|Bilateria,48IIW@7711|Chordata,49F2F@7742|Vertebrata,4GI94@8782|Aves	33208|Metazoa	U	Ras-related protein Rab-18-B-like	-	-	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
WLSH3_k127_2543077_3	1229909.NSED_07225	1.864e-17	87.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
WLSH3_k127_2543077_4	27923.ML03267a-PA	0.0001385	46.0	KOG0092@1|root,KOG0092@2759|Eukaryota,38HB3@33154|Opisthokonta,3B9WF@33208|Metazoa	33208|Metazoa	U	member RAS oncogene family	-	-	-	ko:K07888,ko:K07889	ko04014,ko04144,ko04145,ko04962,ko05146,ko05152,map04014,map04144,map04145,map04962,map05146,map05152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_25687_0	192952.MM_2716	3.549e-45	176.0	COG0608@1|root,arCOG00424@2157|Archaea,2XVF6@28890|Euryarchaeota,2N93U@224756|Methanomicrobia	224756|Methanomicrobia	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
WLSH3_k127_2575142_1	1042877.GQS_01240	1.928e-89	306.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
WLSH3_k127_2575142_2	1365176.N186_06365	1.022e-47	183.0	COG0496@1|root,arCOG02303@2157|Archaea,2XQA4@28889|Crenarchaeota	28889|Crenarchaeota	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
WLSH3_k127_2575142_4	1227457.C451_03399	0.0006341	44.0	arCOG02989@1|root,arCOG02989@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2575142_0	565033.GACE_1144	5.382e-100	340.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,246S6@183980|Archaeoglobi	183980|Archaeoglobi	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
WLSH3_k127_2575142_3	754027.HMPREF9554_02569	0.0003695	46.0	COG2820@1|root,COG2820@2|Bacteria,2J5TI@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
WLSH3_k127_2578073_0	1379698.RBG1_1C00001G0798	4.582e-36	149.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	HEAT_2,Peptidase_M1
WLSH3_k127_2581113_0	1122919.KB905557_gene1171	7.235e-35	142.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,26QTA@186822|Paenibacillaceae	91061|Bacilli	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
WLSH3_k127_2581113_1	351160.RCIX86	2.131e-32	134.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_2589835_0	69014.TK1031	2.044e-126	416.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,242JH@183968|Thermococci	183968|Thermococci	E	Possible Fer4-like domain in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
WLSH3_k127_2589835_1	1343739.PAP_08445	2.204e-104	346.0	COG2820@1|root,arCOG01324@2157|Archaea,2XSWN@28890|Euryarchaeota,243RY@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
WLSH3_k127_2625674_2	42099.EPrPV00000018684	0.0004975	47.0	KOG4115@1|root,KOG4115@2759|Eukaryota,1MH58@121069|Pythiales	121069|Pythiales	DN	Dynein light chain 2B. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
WLSH3_k127_2625674_0	673860.AciM339_0619	1.349e-110	370.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,3F2HE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,Rad51
WLSH3_k127_2625674_1	453591.Igni_1108	3.334e-41	158.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
WLSH3_k127_263811_0	1121472.AQWN01000003_gene1546	2.848e-125	409.0	COG1960@1|root,COG1960@2|Bacteria,1TRR9@1239|Firmicutes,24AJB@186801|Clostridia,260H9@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_263811_1	1303518.CCALI_00908	1.11e-37	151.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	tdsD	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_263811_2	1191523.MROS_2656	2.515e-32	137.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
WLSH3_k127_263811_3	69014.TK2061	2.633e-29	130.0	COG0306@1|root,arCOG02267@2157|Archaea,2XSUU@28890|Euryarchaeota,243W8@183968|Thermococci	183968|Thermococci	P	Phosphate	-	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
WLSH3_k127_263811_4	186497.PF1395	5.644e-10	66.0	COG1392@1|root,arCOG02640@2157|Archaea,2XWHY@28890|Euryarchaeota,242W3@183968|Thermococci	183968|Thermococci	K	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
WLSH3_k127_2639762_0	580340.Tlie_0352	2.531e-39	168.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_2684162_0	641143.HMPREF9331_01282	3.027e-15	85.0	COG0454@1|root,COG0454@2|Bacteria,4NU6Y@976|Bacteroidetes,1I6EG@117743|Flavobacteriia,1ERV6@1016|Capnocytophaga	976|Bacteroidetes	K	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
WLSH3_k127_2725855_0	909663.KI867150_gene2279	3.692e-94	319.0	COG0037@1|root,COG0037@2|Bacteria,1NKHX@1224|Proteobacteria,42Q26@68525|delta/epsilon subdivisions,2WPER@28221|Deltaproteobacteria,2MSF2@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	TIGRFAM N-acetyl sugar amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2725855_1	909663.KI867150_gene1592	1.681e-67	235.0	COG0171@1|root,COG0171@2|Bacteria,1QHZ4@1224|Proteobacteria,42QD8@68525|delta/epsilon subdivisions,2WMK9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
WLSH3_k127_2745468_1	211165.AJLN01000152_gene6817	2.973e-06	55.0	COG2020@1|root,COG2020@2|Bacteria,1G5RJ@1117|Cyanobacteria	1117|Cyanobacteria	O	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_2745468_0	935948.KE386494_gene869	1.092e-33	143.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia,42GGS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
WLSH3_k127_2746638_0	1218084.BBJK01000145_gene7422	0.0002965	53.0	COG1522@1|root,COG1522@2|Bacteria,1RCWU@1224|Proteobacteria,2WFJZ@28216|Betaproteobacteria,1K2IV@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
WLSH3_k127_2748865_0	485913.Krac_6352	5.623e-125	415.0	COG0402@1|root,COG0402@2|Bacteria,2G6DG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,CYTH
WLSH3_k127_2748865_1	1382306.JNIM01000001_gene4084	1.088e-15	89.0	COG4412@1|root,COG4412@2|Bacteria,2G622@200795|Chloroflexi	200795|Chloroflexi	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
WLSH3_k127_2748865_2	604354.TSIB_1966	2.384e-13	78.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_2753384_1	415426.Hbut_0268	4.523e-35	149.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRIJ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_2753384_0	264732.Moth_1918	1.164e-73	255.0	COG1061@1|root,COG1061@2|Bacteria,1TPDM@1239|Firmicutes,24CK8@186801|Clostridia	186801|Clostridia	KL	Helicase conserved C-terminal domain	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
WLSH3_k127_2762748_0	186497.PF0230	2.128e-19	96.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_2773427_1	1304875.JAFZ01000003_gene549	7.475e-05	49.0	COG1977@1|root,COG1977@2|Bacteria,3TBJI@508458|Synergistetes	508458|Synergistetes	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
WLSH3_k127_2773427_0	1123057.P872_05170	6.201e-13	74.0	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes,47KXN@768503|Cytophagia	976|Bacteroidetes	S	Penicillin amidase	pac	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
WLSH3_k127_2801654_1	384616.Pisl_1038	5.37e-55	203.0	COG3294@1|root,arCOG04230@2157|Archaea,2XQ9R@28889|Crenarchaeota	28889|Crenarchaeota	S	phosphohydrolase	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_2801654_2	1459636.NTE_02308	4.377e-13	74.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
WLSH3_k127_2801654_0	332101.JIBU02000008_gene522	3.566e-59	213.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,36EQU@31979|Clostridiaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
WLSH3_k127_2807278_1	644282.Deba_1257	5.386e-36	146.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,42RKE@68525|delta/epsilon subdivisions,2WS0D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
WLSH3_k127_2807278_0	69014.TK0509	2.908e-54	196.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,242TB@183968|Thermococci	183968|Thermococci	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
WLSH3_k127_2815321_3	224325.AF_2286	6.807e-30	126.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,245VD@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
WLSH3_k127_2815321_1	1379698.RBG1_1C00001G1133	2.618e-67	245.0	COG1575@1|root,COG1575@2|Bacteria,2NPNN@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
WLSH3_k127_2815321_0	1089553.Tph_c19580	9.008e-72	258.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
WLSH3_k127_2815321_2	635013.TherJR_0544	4.424e-50	184.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPG1@1239|Firmicutes,24C2Y@186801|Clostridia,263T4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
WLSH3_k127_2816059_2	604354.TSIB_0686	3.421e-05	49.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
WLSH3_k127_2816059_0	289376.THEYE_A1394	6.808e-125	410.0	COG1260@1|root,COG1260@2|Bacteria	2|Bacteria	I	inositol-3-phosphate synthase activity	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
WLSH3_k127_2816059_1	1027292.HMPREF9372_2929	3.628e-21	95.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,4H9SM@91061|Bacilli,26EF0@186818|Planococcaceae	91061|Bacilli	G	M42 glutamyl aminopeptidase	ysdC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
WLSH3_k127_28201_0	662479.C440_10373	1.88e-93	324.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
WLSH3_k127_28201_1	573063.Metin_1349	8.396e-88	299.0	COG0176@1|root,arCOG05061@2157|Archaea,2XTET@28890|Euryarchaeota,23Q23@183939|Methanococci	183939|Methanococci	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
WLSH3_k127_28201_2	1232410.KI421426_gene1403	2.57e-72	250.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,43TEV@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
WLSH3_k127_28201_3	1303518.CCALI_02185	5.132e-63	223.0	COG0249@1|root,COG0249@2|Bacteria	2|Bacteria	L	mismatched DNA binding	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
WLSH3_k127_2831030_4	589924.Ferp_1486	5.975e-33	132.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota,2468P@183980|Archaeoglobi	183980|Archaeoglobi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_2831030_2	1121472.AQWN01000009_gene439	3.615e-89	306.0	COG2070@1|root,COG2070@2|Bacteria,1VTQJ@1239|Firmicutes,24ZN0@186801|Clostridia,26495@186807|Peptococcaceae	186801|Clostridia	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
WLSH3_k127_2831030_1	926569.ANT_14660	3.267e-90	310.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
WLSH3_k127_2831030_0	1163730.FFONT_0226	2.289e-141	469.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_2831030_3	557598.LHK_01745	2.915e-81	284.0	COG2195@1|root,COG2195@2|Bacteria,1MUWK@1224|Proteobacteria,2VHR4@28216|Betaproteobacteria,2KQ8V@206351|Neisseriales	206351|Neisseriales	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_2856737_0	5762.XP_002679184.1	2.183e-50	189.0	COG3616@1|root,2QRZ0@2759|Eukaryota	2759|Eukaryota	E	D-serine ammonia-lyase activity	-	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008721,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0017144,GO:0019478,GO:0019752,GO:0036088,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046416,GO:0070178,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.18	ko:K20498	ko00260,map00260	-	R00221	RC02600	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N,D-ser_dehydrat
WLSH3_k127_2866375_6	868131.MSWAN_0433	5.984e-13	72.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23P79@183925|Methanobacteria	183925|Methanobacteria	C	hydrogenase maturation protease HycI	hycI	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
WLSH3_k127_2866375_1	1459636.NTE_00969	1.946e-92	314.0	COG0182@1|root,arCOG01123@2157|Archaea,41SF9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
WLSH3_k127_2866375_3	335543.Sfum_3308	1.463e-22	100.0	2E32K@1|root,32Y2U@2|Bacteria,1N8SE@1224|Proteobacteria,42WC1@68525|delta/epsilon subdivisions,2WS7P@28221|Deltaproteobacteria,2MQPE@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2866375_5	1041930.Mtc_0079	5.12e-13	79.0	COG0533@1|root,arCOG01185@2157|Archaea	1041930.Mtc_0079|-	F	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2866375_0	390874.Tpet_1772	1.25e-177	580.0	COG1743@1|root,COG1743@2|Bacteria	2|Bacteria	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156,N6_N4_Mtase
WLSH3_k127_2866375_2	926569.ANT_22510	1.314e-61	220.0	COG1028@1|root,COG1028@2|Bacteria,2G6GQ@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.140	ko:K00059,ko:K00068	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05607,R07759,R07763,R10116,R10120,R11671	RC00029,RC00085,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
WLSH3_k127_2866375_4	977880.RALTA_B2024	3.166e-13	80.0	COG1413@1|root,COG1413@2|Bacteria,1R4SF@1224|Proteobacteria,2VQ82@28216|Betaproteobacteria,1KHI1@119060|Burkholderiaceae	28216|Betaproteobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
WLSH3_k127_2873495_0	580340.Tlie_1732	3.994e-220	691.0	COG0031@1|root,COG0031@2|Bacteria,3T9XD@508458|Synergistetes	508458|Synergistetes	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	PALP
WLSH3_k127_2873495_1	204669.Acid345_1196	1.274e-39	153.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3Y2P5@57723|Acidobacteria,2JMA3@204432|Acidobacteriia	204432|Acidobacteriia	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
WLSH3_k127_289384_1	1121405.dsmv_0332	7.679e-47	180.0	COG2204@1|root,COG2204@2|Bacteria,1RH7I@1224|Proteobacteria,42STG@68525|delta/epsilon subdivisions,2WP9G@28221|Deltaproteobacteria,2MKAX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WLSH3_k127_289384_0	374847.Kcr_0159	1.717e-87	306.0	COG0665@1|root,arCOG00755@2157|Archaea	2157|Archaea	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO
WLSH3_k127_290782_0	269797.Mbar_A3230	3.872e-92	319.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
WLSH3_k127_290782_2	1041930.Mtc_1643	1.642e-60	225.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
WLSH3_k127_290782_3	70601.3257966	2.261e-37	144.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
WLSH3_k127_290782_1	192952.MM_0114	1.255e-61	230.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
WLSH3_k127_2926078_0	1278971.AOGF01000025_gene1985	1.332e-76	279.0	COG1073@1|root,COG1073@2|Bacteria,1N8YB@1224|Proteobacteria,1S74C@1236|Gammaproteobacteria,1Y7QS@135625|Pasteurellales	135625|Pasteurellales	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
WLSH3_k127_29723_0	429009.Adeg_1792	1.882e-155	509.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42FCI@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
WLSH3_k127_29723_1	1499967.BAYZ01000014_gene6411	7.64e-21	99.0	COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
WLSH3_k127_2981485_4	930945.SiRe_1724	7.679e-28	122.0	COG1938@1|root,arCOG00347@2157|Archaea,2XPV9@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
WLSH3_k127_2981485_6	572546.Arcpr_0562	6.51e-07	59.0	COG1374@1|root,arCOG00993@2157|Archaea,2Y0D1@28890|Euryarchaeota,2474B@183980|Archaeoglobi	183980|Archaeoglobi	J	PUA domain	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
WLSH3_k127_2981485_1	933801.Ahos_0774	5.282e-80	278.0	COG0144@1|root,arCOG00973@2157|Archaea,2XQ6R@28889|Crenarchaeota	28889|Crenarchaeota	J	NOL1 NOP2 sun family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
WLSH3_k127_2981485_0	633148.Tagg_0552	4.538e-102	347.0	COG0498@1|root,arCOG01434@2157|Archaea,2XQ1A@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_2981485_3	673860.AciM339_0412	2.968e-31	130.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,3F3BY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM adenylyl cyclase CyaB	cyaB	GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
WLSH3_k127_2981485_2	521011.Mpal_2427	2.722e-37	148.0	COG1418@1|root,arCOG01860@2157|Archaea,2XT54@28890|Euryarchaeota,2NBH8@224756|Methanomicrobia	224756|Methanomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_2981485_5	755178.Cyan10605_2779	6.398e-10	72.0	COG1305@1|root,COG1305@2|Bacteria,1FZW2@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Transglutaminase-like superfamily	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
WLSH3_k127_2984172_2	1243664.CAVL020000046_gene2219	5.316e-20	105.0	COG2234@1|root,COG2234@2|Bacteria,1UFM1@1239|Firmicutes,4HCR1@91061|Bacilli,1ZR6G@1386|Bacillus	91061|Bacilli	S	Peptidase family M28	ywaD	-	3.4.11.10,3.4.11.6	ko:K19701	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
WLSH3_k127_2984172_3	794903.OPIT5_23620	9.094e-11	75.0	COG3266@1|root,COG3266@2|Bacteria,46Z90@74201|Verrucomicrobia,3K9IV@414999|Opitutae	414999|Opitutae	M	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	PA14
WLSH3_k127_2984172_0	593750.Metfor_2908	1.276e-86	297.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2NA8Q@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM thiamine pyrophosphate enzyme	porB-2	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_2984172_1	1041930.Mtc_0842	2.04e-69	245.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,2N98Z@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA-1	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_3002714_2	880073.Calab_0419	4.956e-48	181.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
WLSH3_k127_3002714_0	391623.TERMP_00536	3.193e-101	344.0	COG0374@1|root,arCOG01549@2157|Archaea,2Y2IM@28890|Euryarchaeota,2434B@183968|Thermococci	183968|Thermococci	C	Nickel-dependent hydrogenase	-	-	1.12.1.3,1.12.1.5	ko:K17993	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
WLSH3_k127_3002714_1	666510.ASAC_0833	1.33e-92	310.0	COG0499@1|root,arCOG04137@2157|Archaea,2XPXV@28889|Crenarchaeota	28889|Crenarchaeota	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
WLSH3_k127_3024486_3	439235.Dalk_4525	3.613e-36	142.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2WJQW@28221|Deltaproteobacteria,2MHRC@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
WLSH3_k127_3024486_1	96561.Dole_2975	2.988e-98	332.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2MK4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_3024486_2	215803.DB30_3758	1.72e-73	254.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_3024486_0	886379.AEWI01000034_gene3015	6.887e-117	383.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,4NF6I@976|Bacteroidetes,2FNS0@200643|Bacteroidia,3XJFZ@558415|Marinilabiliaceae	976|Bacteroidetes	H	GTP cyclohydrolase II	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
WLSH3_k127_3024486_4	1313421.JHBV01000015_gene5746	1.606e-06	50.0	COG1215@1|root,COG1215@2|Bacteria,4NN4F@976|Bacteroidetes,1J064@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WLSH3_k127_3025265_0	269799.Gmet_2181	1.288e-47	190.0	COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,43AEC@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
WLSH3_k127_3037431_1	679926.Mpet_0051	2.357e-18	91.0	arCOG04915@1|root,arCOG04915@2157|Archaea,2Y3CG@28890|Euryarchaeota,2NAQQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3037431_0	370438.PTH_1555	3.274e-88	301.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,2611F@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_3037431_2	135651.CBN06271	9.51e-12	68.0	KOG4423@1|root,KOG4423@2759|Eukaryota,38BWT@33154|Opisthokonta,3B9BE@33208|Metazoa,3CV0Z@33213|Bilateria,40DKZ@6231|Nematoda,1KZ2Y@119089|Chromadorea,40ZVN@6236|Rhabditida	33208|Metazoa	U	Ras family	RAB32	GO:0000166,GO:0000323,GO:0001882,GO:0001883,GO:0002376,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005764,GO:0005768,GO:0005769,GO:0005773,GO:0005776,GO:0005783,GO:0005794,GO:0005802,GO:0005829,GO:0006464,GO:0006725,GO:0006726,GO:0006727,GO:0006807,GO:0006810,GO:0006856,GO:0006873,GO:0006885,GO:0006996,GO:0007005,GO:0007033,GO:0007040,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008055,GO:0008057,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009894,GO:0009987,GO:0010256,GO:0010506,GO:0010876,GO:0010883,GO:0010941,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0018130,GO:0019001,GO:0019222,GO:0019438,GO:0019538,GO:0019725,GO:0019748,GO:0019867,GO:0019882,GO:0019915,GO:0021700,GO:0022607,GO:0023052,GO:0030003,GO:0030004,GO:0030139,GO:0030154,GO:0030641,GO:0030659,GO:0030742,GO:0031090,GO:0031323,GO:0031329,GO:0031410,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0031982,GO:0031984,GO:0032438,GO:0032482,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0033036,GO:0033059,GO:0033060,GO:0033162,GO:0033363,GO:0034613,GO:0035556,GO:0035639,GO:0035646,GO:0035650,GO:0035651,GO:0036094,GO:0036211,GO:0036461,GO:0042440,GO:0042441,GO:0042470,GO:0042592,GO:0042886,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043324,GO:0043412,GO:0043473,GO:0043474,GO:0043476,GO:0043482,GO:0043485,GO:0043687,GO:0044085,GO:0044232,GO:0044233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0044550,GO:0044840,GO:0044841,GO:0044877,GO:0045009,GO:0045184,GO:0045335,GO:0045851,GO:0046148,GO:0046152,GO:0046158,GO:0046483,GO:0046907,GO:0048066,GO:0048069,GO:0048072,GO:0048753,GO:0048757,GO:0048770,GO:0048869,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0050931,GO:0051179,GO:0051234,GO:0051235,GO:0051452,GO:0051453,GO:0051641,GO:0051649,GO:0051716,GO:0055067,GO:0055080,GO:0055082,GO:0060155,GO:0065007,GO:0065008,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072657,GO:0080171,GO:0090382,GO:0090383,GO:0090741,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098771,GO:0098791,GO:0098805,GO:1901214,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1903232,GO:1905952	-	ko:K07918,ko:K07923	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
WLSH3_k127_3059690_0	1151117.AJLF01000002_gene509	2.725e-43	168.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
WLSH3_k127_3087481_0	1009370.ALO_12221	3.392e-15	87.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes	1239|Firmicutes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2
WLSH3_k127_3109314_0	384616.Pisl_1480	1.972e-06	60.0	COG0675@1|root,arCOG00679@2157|Archaea	2157|Archaea	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
WLSH3_k127_3111494_0	1280689.AUJC01000004_gene181	8.909e-15	87.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36DEY@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_3111494_1	933801.Ahos_1505	1.171e-08	61.0	COG1695@1|root,arCOG00002@2157|Archaea,2XRBK@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_3126842_0	33178.CADATEAP00001052	2.728e-07	63.0	29DCH@1|root,2RKGE@2759|Eukaryota,39VKP@33154|Opisthokonta,3P0RU@4751|Fungi,3QSIU@4890|Ascomycota,20J60@147545|Eurotiomycetes	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3139775_0	1313172.YM304_28200	6.535e-66	239.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_3139775_3	521045.Kole_0507	1.898e-12	68.0	COG1522@1|root,COG1522@2|Bacteria,2GEG4@200918|Thermotogae	200918|Thermotogae	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11
WLSH3_k127_3139775_1	868131.MSWAN_1839	1.283e-49	184.0	COG1926@1|root,arCOG00041@2157|Archaea,2XWHP@28890|Euryarchaeota	28890|Euryarchaeota	F	phosphoribosyltransferases	prt	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
WLSH3_k127_3139775_2	1265505.ATUG01000002_gene2379	8.319e-28	124.0	COG1148@1|root,COG1148@2|Bacteria,1R0SK@1224|Proteobacteria,43EFN@68525|delta/epsilon subdivisions,2X89E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_3141666_1	666510.ASAC_1468	8.078e-46	181.0	COG0648@1|root,arCOG01894@2157|Archaea,2XPUX@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
WLSH3_k127_3141666_0	246194.CHY_1295	2.788e-54	196.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1V3TD@1239|Firmicutes,24I7A@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3141666_2	1056495.Calag_0209	6.133e-28	125.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQNM@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
WLSH3_k127_3213451_1	500153.JOEK01000009_gene5062	2.397e-62	222.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_3213451_0	1444711.CCJF01000005_gene546	2.067e-105	364.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
WLSH3_k127_3223916_1	945713.IALB_2773	2.785e-24	114.0	COG1108@1|root,COG1108@2|Bacteria	2|Bacteria	P	ABC-type Mn2 Zn2 transport systems permease components	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
WLSH3_k127_3223916_0	1042877.GQS_01045	1.113e-27	117.0	COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota,2434A@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02074	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
WLSH3_k127_3229393_3	1203611.KB894546_gene165	0.0003042	51.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,2FMI3@200643|Bacteroidia,22UXJ@171550|Rikenellaceae	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
WLSH3_k127_3229393_0	643562.Daes_3090	6.203e-26	118.0	COG0454@1|root,COG0456@2|Bacteria,1QWS7@1224|Proteobacteria,43C57@68525|delta/epsilon subdivisions,2X7FK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_3229393_2	1343739.PAP_00290	0.0001041	53.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_3229393_1	4572.TRIUR3_16838-P1	2.079e-11	68.0	KOG3276@1|root,KOG3276@2759|Eukaryota,37V9I@33090|Viridiplantae,3GJD9@35493|Streptophyta,3M0VK@4447|Liliopsida,3IHK8@38820|Poales	35493|Streptophyta	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
WLSH3_k127_3238159_2	6183.Smp_104310.1	5.258e-25	109.0	COG1100@1|root,KOG0087@2759|Eukaryota,38FAA@33154|Opisthokonta,3BE79@33208|Metazoa,3CY4B@33213|Bilateria	33208|Metazoa	U	melanosome transport	-	-	-	ko:K02105,ko:K07904,ko:K07905	ko04015,ko04144,ko04152,ko04310,ko04390,ko04510,ko04520,ko04550,ko04670,ko04916,ko04919,ko04934,ko04961,ko04962,ko04972,ko05100,ko05130,ko05165,ko05166,ko05167,ko05200,ko05205,ko05210,ko05213,ko05215,ko05216,ko05217,ko05224,ko05225,ko05226,ko05412,ko05418,map04015,map04144,map04152,map04310,map04390,map04510,map04520,map04550,map04670,map04916,map04919,map04934,map04961,map04962,map04972,map05100,map05130,map05165,map05166,map05167,map05200,map05205,map05210,map05213,map05215,map05216,map05217,map05224,map05225,map05226,map05412,map05418	M00677	-	-	ko00000,ko00001,ko00002,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_3238159_0	693661.Arcve_0846	3.353e-62	227.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,245T6@183980|Archaeoglobi	183980|Archaeoglobi	J	phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
WLSH3_k127_3238159_1	1139219.I569_00036	9.968e-35	135.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,4AZE3@81852|Enterococcaceae	91061|Bacilli	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WLSH3_k127_3279084_0	4565.Traes_4BL_E74923982.1	1.428e-95	340.0	COG1697@1|root,KOG2795@2759|Eukaryota,37QGK@33090|Viridiplantae,3G85Y@35493|Streptophyta,3KVMF@4447|Liliopsida,3I71X@38820|Poales	35493|Streptophyta	L	Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity	TOP6A	GO:0000003,GO:0000228,GO:0000280,GO:0000706,GO:0000729,GO:0001708,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0008544,GO:0009888,GO:0009913,GO:0009957,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0022402,GO:0022414,GO:0030154,GO:0030855,GO:0031974,GO:0031981,GO:0032502,GO:0033554,GO:0034641,GO:0035825,GO:0042138,GO:0042623,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045165,GO:0046483,GO:0048285,GO:0048856,GO:0048869,GO:0050896,GO:0051321,GO:0051716,GO:0060429,GO:0061505,GO:0061982,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046	-	ko:K10878	ko04113,map04113	-	-	-	ko00000,ko00001,ko03400	-	-	-	TP6A_N
WLSH3_k127_3279084_1	234621.RER_53090	5.146e-42	167.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,4FW0U@85025|Nocardiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	ytpA	GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010941,GO:0010942,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0030312,GO:0031341,GO:0031343,GO:0031640,GO:0035821,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0046486,GO:0046503,GO:0047372,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051817,GO:0051818,GO:0051883,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052689,GO:0065007,GO:0071704,GO:0071944,GO:1901575	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
WLSH3_k127_3279084_2	760568.Desku_1299	1.667e-40	158.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
WLSH3_k127_3284137_0	671065.MetMK1DRAFT_00031660	6.168e-66	236.0	COG0047@1|root,arCOG00102@2157|Archaea,2XQC4@28889|Crenarchaeota	28889|Crenarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
WLSH3_k127_3284137_1	698737.SLGD_01808	1.453e-59	218.0	COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,4H9U8@91061|Bacilli,4GXTP@90964|Staphylococcaceae	91061|Bacilli	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
WLSH3_k127_3284137_3	387631.Asulf_00339	2.533e-05	48.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,246UQ@183980|Archaeoglobi	183980|Archaeoglobi	F	IMP biosynthesis enzyme PurP domain protein	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
WLSH3_k127_3284137_2	742725.HMPREF9450_00377	3.455e-08	59.0	COG3345@1|root,COG3345@2|Bacteria,4NZUR@976|Bacteroidetes,2FNUD@200643|Bacteroidia	976|Bacteroidetes	G	Melibiase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
WLSH3_k127_3295468_0	1123276.KB893262_gene4037	2.888e-29	128.0	COG1090@1|root,COG1090@2|Bacteria	2|Bacteria	S	coenzyme binding	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Lipocalin_2,NAD_binding_10
WLSH3_k127_3309363_0	1444310.JANV01000166_gene4423	3.442e-17	96.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,1ZPV5@1386|Bacillus	91061|Bacilli	O	Belongs to the peptidase S8 family	epr	GO:0005575,GO:0005576	-	ko:K13277	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	A2M_N,CW_binding_2,Peptidase_S8,SLH
WLSH3_k127_3317993_1	1197477.IA57_08470	1.539e-38	160.0	COG4249@1|root,COG4249@2|Bacteria,4PHQW@976|Bacteroidetes,1I5CW@117743|Flavobacteriia	976|Bacteroidetes	O	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3317993_0	304371.MCP_2203	2.161e-41	164.0	COG1266@1|root,arCOG02766@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_33412_9	135651.CBN21953	0.0004795	46.0	KOG3780@1|root,KOG3780@2759|Eukaryota,38D4U@33154|Opisthokonta,3BJG5@33208|Metazoa,3CY15@33213|Bilateria,40HVP@6231|Nematoda,1M3S9@119089|Chromadorea,4116I@6236|Rhabditida	33208|Metazoa	S	Arrestin (or S-antigen), C-terminal domain	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0060255,GO:0065007	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
WLSH3_k127_33412_2	234267.Acid_6989	9.109e-87	295.0	COG1013@1|root,COG1013@2|Bacteria,3Y514@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_33412_5	868131.MSWAN_0222	5.26e-49	181.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23PH1@183925|Methanobacteria	183925|Methanobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
WLSH3_k127_33412_3	1256908.HMPREF0373_03186	2.266e-66	235.0	COG1775@1|root,COG1924@1|root,COG1775@2|Bacteria,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,25WB2@186806|Eubacteriaceae	186801|Clostridia	I	BadF/BadG/BcrA/BcrD ATPase family	hgdC_1	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
WLSH3_k127_33412_1	1121422.AUMW01000002_gene2132	1.751e-101	344.0	COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,2493U@186801|Clostridia,260S9@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
WLSH3_k127_33412_6	272563.CD630_03980	3.151e-22	110.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,25R6U@186804|Peptostreptococcaceae	186801|Clostridia	E	2-hydroxyglutaryl-CoA dehydratase, D-component	hgdB	-	1.3.7.8,4.2.1.157	ko:K04112,ko:K20026	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
WLSH3_k127_33412_0	644282.Deba_0138	8.415e-203	646.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_33412_8	867903.ThesuDRAFT_01312	0.0002123	47.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,3WCXQ@538999|Clostridiales incertae sedis	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_33412_7	1187851.A33M_1266	4.408e-12	79.0	COG1073@1|root,COG1073@2|Bacteria,1N8YB@1224|Proteobacteria,2TVHE@28211|Alphaproteobacteria,3FDMJ@34008|Rhodovulum	28211|Alphaproteobacteria	S	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WLSH3_k127_33412_4	529709.PYCH_04900	1.11e-49	183.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2439Z@183968|Thermococci	183968|Thermococci	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WLSH3_k127_3343189_1	1499967.BAYZ01000026_gene1636	4.064e-38	146.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
WLSH3_k127_3343189_0	1163730.FFONT_0366	1.363e-41	168.0	COG5014@1|root,arCOG05120@2157|Archaea,2XPWW@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_3343189_2	632292.Calhy_0206	7.517e-33	134.0	COG0655@1|root,COG0655@2|Bacteria,1V5YT@1239|Firmicutes,25CB1@186801|Clostridia,42H09@68295|Thermoanaerobacterales	186801|Clostridia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
WLSH3_k127_3343189_6	243164.DET0017	7.124e-11	66.0	2BQDM@1|root,32J8W@2|Bacteria,2GB0B@200795|Chloroflexi,34DPG@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3343189_3	1408422.JHYF01000024_gene3837	5.575e-26	117.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,24HZH@186801|Clostridia,36G4R@31979|Clostridiaceae	186801|Clostridia	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
WLSH3_k127_3343189_5	351160.RCIX2683	3.718e-12	72.0	COG1970@1|root,arCOG05213@2157|Archaea	2157|Archaea	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
WLSH3_k127_3343189_4	386456.JQKN01000010_gene620	2.149e-23	105.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
WLSH3_k127_3355706_2	1408323.JQKK01000003_gene2767	2.854e-45	168.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,27J0U@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
WLSH3_k127_3355706_0	1123508.JH636440_gene1975	2.941e-93	316.0	COG0524@1|root,COG0524@2|Bacteria,2IWUH@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
WLSH3_k127_3355706_1	1267534.KB906756_gene261	5.197e-60	214.0	COG0800@1|root,COG0800@2|Bacteria,3Y4HZ@57723|Acidobacteria,2JKJ9@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
WLSH3_k127_3355706_3	247490.KSU1_C1639	1.036e-24	109.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
WLSH3_k127_3355706_4	485918.Cpin_3107	4.547e-13	74.0	2DD0S@1|root,2ZG2P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_336261_2	443254.Marpi_1833	2.564e-07	63.0	COG2374@1|root,COG4085@1|root,COG2374@2|Bacteria,COG4085@2|Bacteria,2GCXZ@200918|Thermotogae	200918|Thermotogae	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
WLSH3_k127_336261_0	743525.TSC_c03950	6.596e-42	170.0	COG0446@1|root,COG0446@2|Bacteria,1WI5H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
WLSH3_k127_336261_1	391624.OIHEL45_11965	1.437e-09	71.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	cspBA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
WLSH3_k127_336637_3	1459636.NTE_02874	2.634e-17	94.0	COG2404@1|root,arCOG00423@2157|Archaea	2157|Archaea	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_336637_0	439235.Dalk_2981	2.319e-133	447.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42Q2C@68525|delta/epsilon subdivisions,2WKNN@28221|Deltaproteobacteria,2MN1W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
WLSH3_k127_336637_2	767817.Desgi_0752	1.705e-26	116.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
WLSH3_k127_336637_1	5888.CAK70949	1.574e-28	119.0	COG1100@1|root,KOG0098@2759|Eukaryota,3ZDYP@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_3366834_2	525904.Tter_0696	1.071e-11	78.0	COG0419@1|root,COG1122@1|root,COG0419@2|Bacteria,COG1122@2|Bacteria	2|Bacteria	P	ATPase activity	sbcC	-	-	ko:K03546,ko:K16786,ko:K16787,ko:K19171	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03400	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	AAA_23,ABC_tran,Rad50_zn_hook,SMC_N,SbcCD_C
WLSH3_k127_3366834_1	679926.Mpet_1030	5.608e-16	91.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,2NA2J@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
WLSH3_k127_3366834_0	1095769.CAHF01000005_gene1567	1.555e-105	362.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853,DUF87,PLDc_2
WLSH3_k127_3371593_1	399550.Smar_0290	2.735e-63	224.0	COG0451@1|root,arCOG01369@2157|Archaea,2XPYT@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
WLSH3_k127_3371593_2	397948.Cmaq_1904	8.372e-15	81.0	COG0727@1|root,arCOG02579@2157|Archaea	2157|Archaea	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WLSH3_k127_3371593_0	1094980.Mpsy_2918	9.546e-88	302.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9D7@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_3371593_3	452637.Oter_2137	4.36e-06	52.0	COG2006@1|root,COG2006@2|Bacteria,46U2P@74201|Verrucomicrobia,3K77Y@414999|Opitutae	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
WLSH3_k127_3372189_2	439481.Aboo_1481	1.48e-27	129.0	arCOG08157@1|root,arCOG08157@2157|Archaea,2Y70I@28890|Euryarchaeota,3F332@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3372189_1	1226325.HMPREF1548_04170	9.887e-43	169.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
WLSH3_k127_3372189_3	1235788.C802_03337	1.202e-22	111.0	COG2327@1|root,COG2327@2|Bacteria,4NRH4@976|Bacteroidetes,2FN39@200643|Bacteroidia,4AKTT@815|Bacteroidaceae	976|Bacteroidetes	S	Polysaccharide pyruvyl transferase	-	-	-	ko:K16710	-	-	-	-	ko00000	-	-	-	PS_pyruv_trans
WLSH3_k127_3372189_0	1128421.JAGA01000003_gene3216	3.652e-65	235.0	COG0438@1|root,COG0438@2|Bacteria,2NR53@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase 4-like domain	rgpA	-	-	ko:K12996	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	DUF1972,Glyco_trans_1_4,Glycos_transf_1
WLSH3_k127_3377369_1	1343739.PAP_06100	4.087e-58	211.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
WLSH3_k127_3377369_5	195522.BD01_0919	1.5e-15	85.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2434N@183968|Thermococci	183968|Thermococci	L	Segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
WLSH3_k127_3377369_2	269797.Mbar_A0594	7.834e-30	125.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
WLSH3_k127_3377369_0	1220534.B655_2351	8.09e-103	345.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,23NWV@183925|Methanobacteria	183925|Methanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
WLSH3_k127_3377369_3	797299.HALLA_15405	2.11e-26	112.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23W98@183963|Halobacteria	183963|Halobacteria	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
WLSH3_k127_3377369_6	237368.SCABRO_03881	8.05e-09	65.0	COG1413@1|root,COG1413@2|Bacteria,2J011@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
WLSH3_k127_3377369_4	644281.MFS40622_0008	6.567e-22	100.0	COG0375@1|root,arCOG04426@2157|Archaea,2XY46@28890|Euryarchaeota,23QZX@183939|Methanococci	183939|Methanococci	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
WLSH3_k127_3379705_0	4920.XP_004202586.1	3.58e-13	81.0	COG1100@1|root,KOG0071@2759|Eukaryota,3A2CM@33154|Opisthokonta,3P36Y@4751|Fungi,3QVRS@4890|Ascomycota,3RUN9@4891|Saccharomycetes,47BS9@766764|Debaryomycetaceae	4751|Fungi	U	Belongs to the small GTPase superfamily. Arf family	-	-	-	ko:K07977	-	-	-	-	ko00000,ko04031	-	-	-	Arf
WLSH3_k127_3394773_0	398512.JQKC01000008_gene851	7.362e-47	176.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,3WJUW@541000|Ruminococcaceae	186801|Clostridia	S	B12 binding domain	-	-	-	ko:K14084	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124	RC00035,RC00732,RC02984	ko00000,ko00001,ko00002	-	-	-	B12-binding,B12-binding_2
WLSH3_k127_3394773_1	1123372.AUIT01000017_gene1577	2.377e-39	163.0	COG0277@1|root,COG0277@2|Bacteria,2GHFQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_3394773_2	1121396.KB893084_gene415	2.643e-14	80.0	COG0247@1|root,COG1148@1|root,COG1908@1|root,COG0247@2|Bacteria,COG1148@2|Bacteria,COG1908@2|Bacteria,1R5V3@1224|Proteobacteria,42PS9@68525|delta/epsilon subdivisions,2WK11@28221|Deltaproteobacteria,2MI6T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD
WLSH3_k127_3407841_0	452637.Oter_0018	9.123e-09	65.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
WLSH3_k127_3436838_8	439481.Aboo_0134	1.261e-14	87.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_3436838_9	443143.GM18_2397	9.35e-13	71.0	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_3436838_4	2325.TKV_c19080	4.103e-31	126.0	2DMSV@1|root,32TFU@2|Bacteria,1VC0G@1239|Firmicutes,24Q3V@186801|Clostridia,42IQ0@68295|Thermoanaerobacterales	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
WLSH3_k127_3436838_6	643648.Slip_2187	9.444e-21	97.0	COG4273@1|root,COG4273@2|Bacteria,1VBRH@1239|Firmicutes,24N2C@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
WLSH3_k127_3436838_3	931626.Awo_c22560	1.356e-36	151.0	COG0509@1|root,COG4273@1|root,COG0509@2|Bacteria,COG4273@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,25YAR@186806|Eubacteriaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	DGC,GCV_H
WLSH3_k127_3436838_5	264732.Moth_2219	1.321e-26	111.0	COG1146@1|root,COG1146@2|Bacteria,1VAMF@1239|Firmicutes,24ND9@186801|Clostridia,42IEN@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
WLSH3_k127_3436838_2	264732.Moth_2220	1.119e-49	179.0	COG1148@1|root,COG1148@2|Bacteria,1V4NY@1239|Firmicutes,24IAD@186801|Clostridia,42IDC@68295|Thermoanaerobacterales	186801|Clostridia	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3436838_0	469383.Cwoe_0589	1.028e-125	415.0	COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria	201174|Actinobacteria	P	arsenical-resistance protein	arsB	-	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	-	SBF
WLSH3_k127_3436838_1	195522.BD01_1631	1.004e-70	252.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,243M3@183968|Thermococci	183968|Thermococci	E	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_3436838_10	666510.ASAC_1410	5.917e-10	66.0	COG0640@1|root,arCOG03859@2157|Archaea,2XR12@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
WLSH3_k127_3436838_7	269798.CHU_2541	9.032e-17	92.0	COG1266@1|root,COG1266@2|Bacteria,4NWFF@976|Bacteroidetes,47W33@768503|Cytophagia	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_3456118_1	1178537.BA1_12814	9.649e-15	84.0	COG1177@1|root,COG1177@2|Bacteria,1TR8H@1239|Firmicutes,4HCRJ@91061|Bacilli,1ZQEQ@1386|Bacillus	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
WLSH3_k127_3456118_0	469371.Tbis_1009	1.937e-71	259.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E01K@85010|Pseudonocardiales	201174|Actinobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
WLSH3_k127_3456118_2	1196083.SALWKB12_1404	9.344e-07	54.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria,2KREG@206351|Neisseriales	206351|Neisseriales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_3488460_2	351160.RCIX575	8.481e-09	69.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
WLSH3_k127_3488460_0	565033.GACE_2119	4.833e-102	344.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,245UY@183980|Archaeoglobi	183980|Archaeoglobi	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
WLSH3_k127_3488460_1	867903.ThesuDRAFT_01611	4.981e-63	221.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,249MP@186801|Clostridia	186801|Clostridia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
WLSH3_k127_3506235_0	929556.Solca_3240	1.59e-183	595.0	COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,1IQQY@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase S9, prolyl oligopeptidase, catalytic domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
WLSH3_k127_3510097_1	1167632.AJTR01000180_gene229	2e-07	52.0	COG0451@1|root,COG0451@2|Bacteria,1TSUN@1239|Firmicutes,4HA3D@91061|Bacilli,4GWX2@90964|Staphylococcaceae	91061|Bacilli	M	epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
WLSH3_k127_3510097_0	1304885.AUEY01000101_gene2140	4.504e-301	940.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
WLSH3_k127_3511848_4	1191523.MROS_0763	1.352e-39	156.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	agl	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
WLSH3_k127_3511848_1	224719.Abm4_1203	2.199e-78	273.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,23PC2@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
WLSH3_k127_3511848_7	410359.Pcal_1019	2.929e-05	49.0	COG1977@1|root,arCOG00537@2157|Archaea	2157|Archaea	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
WLSH3_k127_3511848_3	267377.MMP1315	1.246e-41	158.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
WLSH3_k127_3511848_0	1343739.PAP_05655	3.386e-89	302.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2436C@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit beta	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_3511848_2	272558.10174509	9.059e-57	209.0	28JAJ@1|root,2Z95C@2|Bacteria,1UBFJ@1239|Firmicutes,4HHFM@91061|Bacilli,1ZR76@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3511848_6	666510.ASAC_1410	7.471e-06	57.0	COG0640@1|root,arCOG03859@2157|Archaea,2XR12@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
WLSH3_k127_3511848_5	666510.ASAC_0309	1.331e-07	55.0	COG1958@1|root,arCOG00999@2157|Archaea,2XR1U@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
WLSH3_k127_3514420_0	1313301.AUGC01000001_gene1509	7.035e-84	291.0	COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes	976|Bacteroidetes	M	N-acetyl-alpha-D-glucosaminyl L-malate synthase	bshA	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_3514420_1	1033743.CAES01000047_gene678	2.263e-14	81.0	COG2120@1|root,COG2120@2|Bacteria,1TV10@1239|Firmicutes,4HFJQ@91061|Bacilli,26RWT@186822|Paenibacillaceae	91061|Bacilli	S	deacetylase	bshB1	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
WLSH3_k127_353225_0	868131.MSWAN_1145	7.873e-20	96.0	COG1149@1|root,arCOG04073@2157|Archaea	2157|Archaea	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
WLSH3_k127_3533836_1	1047013.AQSP01000140_gene2511	5.005e-42	175.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
WLSH3_k127_3533836_0	477974.Daud_0279	4.327e-125	417.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_354832_1	1174528.JH992891_gene359	3.419e-24	111.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	cypM_2	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
WLSH3_k127_354832_0	555079.Toce_2031	7.537e-93	315.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
WLSH3_k127_3593150_0	582402.Hbal_1499	3.793e-33	141.0	COG0277@1|root,COG0277@2|Bacteria,1N22A@1224|Proteobacteria,2TUDT@28211|Alphaproteobacteria,43ZE8@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_3593150_1	52644.XP_010581064.1	5.797e-14	78.0	KOG3339@1|root,KOG3339@2759|Eukaryota,38Z55@33154|Opisthokonta,3BF7Q@33208|Metazoa,3D2TU@33213|Bilateria,48C0Y@7711|Chordata,48WUA@7742|Vertebrata,4GKSY@8782|Aves	33208|Metazoa	S	ALG14, UDP-N-acetylglucosaminyltransferase subunit	ALG14	GO:0003674,GO:0003824,GO:0004577,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006488,GO:0006490,GO:0006629,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0023052,GO:0030154,GO:0031984,GO:0032502,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045165,GO:0045168,GO:0046331,GO:0048869,GO:0070085,GO:0071704,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.141	ko:K07441	ko00510,ko00513,ko01100,map00510,map00513,map01100	M00055	R05970	-	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT1	-	Alg14
WLSH3_k127_3593150_2	30611.ENSOGAP00000020093	2.133e-13	76.0	COG5017@1|root,KOG3349@2759|Eukaryota,3A88H@33154|Opisthokonta,3BPCV@33208|Metazoa,3D57S@33213|Bilateria,48APN@7711|Chordata,4996B@7742|Vertebrata,3J9IW@40674|Mammalia,35F9A@314146|Euarchontoglires,4MF13@9443|Primates	33208|Metazoa	S	Glycosyltransferase family 28 C-terminal domain	Alg13	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006488,GO:0006490,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043541,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.141	ko:K07432	ko00510,ko00513,ko01100,map00510,map00513,map01100	M00055	R05970	-	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT1	-	Glyco_tran_28_C
WLSH3_k127_3597339_1	290315.Clim_2240	1.616e-19	89.0	COG1162@1|root,COG1162@2|Bacteria,1FEWT@1090|Chlorobi	1090|Chlorobi	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
WLSH3_k127_3604096_0	326423.RBAM_038020	1.9e-92	334.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,4HTGY@91061|Bacilli,1ZQAS@1386|Bacillus	91061|Bacilli	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	yyaE	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
WLSH3_k127_3604096_1	1042877.GQS_03810	4.337e-05	46.0	COG1274@1|root,arCOG05865@2157|Archaea,2XUU1@28890|Euryarchaeota,24380@183968|Thermococci	183968|Thermococci	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
WLSH3_k127_3604643_2	1536775.H70737_09645	2.211e-16	82.0	COG1670@1|root,COG1670@2|Bacteria,1V3Q8@1239|Firmicutes,4HH72@91061|Bacilli,275IE@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
WLSH3_k127_3604643_1	1408310.JHUW01000008_gene2268	5.279e-23	108.0	COG2220@1|root,COG2220@2|Bacteria,4NFJ4@976|Bacteroidetes,2FNMD@200643|Bacteroidia	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
WLSH3_k127_3604643_3	1459636.NTE_02332	1.03e-12	78.0	arCOG10526@1|root,arCOG10526@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3604643_0	1158345.JNLL01000001_gene890	2.91e-45	172.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G425@200783|Aquificae	200783|Aquificae	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
WLSH3_k127_3660208_1	446469.Sked_30580	1.706e-14	79.0	COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria	201174|Actinobacteria	J	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
WLSH3_k127_3660208_0	1125863.JAFN01000001_gene3479	4.168e-57	211.0	COG3875@1|root,COG3875@2|Bacteria,1R79Y@1224|Proteobacteria,42PGD@68525|delta/epsilon subdivisions,2WMB6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
WLSH3_k127_3679046_0	1128421.JAGA01000002_gene275	1.896e-40	153.0	COG0251@1|root,COG0251@2|Bacteria,2NPSA@2323|unclassified Bacteria	2|Bacteria	J	Endoribonuclease L-PSP	rutC	GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.99.10	ko:K09021,ko:K09022	ko00240,ko01100,map00240,map01100	-	R09982,R11098,R11099	RC02768,RC03275,RC03354	ko00000,ko00001,ko01000	-	-	-	Ribonuc_L-PSP
WLSH3_k127_3679046_1	64363.EME48865	0.0008255	49.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CAZ@33154|Opisthokonta,3NVJD@4751|Fungi,3QN69@4890|Ascomycota,1ZZC2@147541|Dothideomycetes,3MJAU@451867|Dothideomycetidae	4751|Fungi	S	Tetratricopeptide repeat	SSN6	GO:0000122,GO:0000228,GO:0000785,GO:0000790,GO:0000988,GO:0000989,GO:0001076,GO:0001190,GO:0001191,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0006139,GO:0006323,GO:0006325,GO:0006333,GO:0006338,GO:0006342,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016458,GO:0016584,GO:0017053,GO:0018130,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031497,GO:0031974,GO:0031981,GO:0032774,GO:0032879,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034728,GO:0035950,GO:0035952,GO:0035953,GO:0035955,GO:0040029,GO:0042304,GO:0042826,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0046483,GO:0046890,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0060255,GO:0062012,GO:0065007,GO:0070013,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0072364,GO:0080090,GO:0080134,GO:0080135,GO:0090087,GO:0090088,GO:0090089,GO:0090304,GO:0090568,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2000531,GO:2000877,GO:2000879,GO:2001020,GO:2001141	-	ko:K06665	ko04011,ko04111,map04011,map04111	-	-	-	ko00000,ko00001,ko03021	-	-	-	TPR_1,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8
WLSH3_k127_3682508_4	1280390.CBQR020000097_gene2196	1.325e-10	70.0	2E6H4@1|root,3314B@2|Bacteria,1VW5U@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3682508_0	391625.PPSIR1_36707	3.343e-43	162.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WLSH3_k127_3682508_3	944565.HMPREF9127_0768	1.704e-12	75.0	290DM@1|root,2ZN2Z@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_3682508_1	234267.Acid_5754	3.37e-32	129.0	COG3324@1|root,COG3324@2|Bacteria,3Y8A9@57723|Acidobacteria	57723|Acidobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_3682508_2	290340.AAur_3039	4.838e-18	89.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
WLSH3_k127_3716567_0	1041930.Mtc_1997	1.052e-08	68.0	COG1297@1|root,arCOG04807@2157|Archaea	2157|Archaea	S	Oligopeptide transporter OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
WLSH3_k127_3744380_1	1123239.KB898627_gene3481	1.686e-38	161.0	COG0657@1|root,COG0657@2|Bacteria,1UYX6@1239|Firmicutes,4HEMG@91061|Bacilli	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
WLSH3_k127_3744380_0	330779.Saci_1311	1.964e-39	151.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
WLSH3_k127_375033_1	1094980.Mpsy_1799	1.07e-22	104.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
WLSH3_k127_375033_0	269797.Mbar_A1179	3.829e-68	243.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
WLSH3_k127_375966_0	45351.EDO32994	4.26e-09	67.0	KOG0073@1|root,KOG0073@2759|Eukaryota,39K0E@33154|Opisthokonta,3BDBM@33208|Metazoa	33208|Metazoa	U	GTP binding	ARL2	GO:0000003,GO:0000132,GO:0000166,GO:0000226,GO:0000278,GO:0000281,GO:0000910,GO:0001505,GO:0001882,GO:0001883,GO:0002791,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0004857,GO:0005095,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005759,GO:0005794,GO:0005813,GO:0005815,GO:0005818,GO:0005819,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005924,GO:0005925,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006897,GO:0006996,GO:0007010,GO:0007017,GO:0007021,GO:0007043,GO:0007049,GO:0007098,GO:0007154,GO:0007163,GO:0007267,GO:0007268,GO:0007269,GO:0007275,GO:0007399,GO:0007405,GO:0007548,GO:0008104,GO:0008150,GO:0008283,GO:0008356,GO:0009790,GO:0009792,GO:0009914,GO:0009987,GO:0010638,GO:0010646,GO:0010810,GO:0010811,GO:0010817,GO:0012505,GO:0015630,GO:0015695,GO:0015696,GO:0015870,GO:0015893,GO:0016020,GO:0016043,GO:0016192,GO:0016328,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0017145,GO:0019001,GO:0019003,GO:0022008,GO:0022402,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023061,GO:0030010,GO:0030054,GO:0030055,GO:0030154,GO:0030155,GO:0030234,GO:0030540,GO:0030695,GO:0030865,GO:0031023,GO:0031110,GO:0031112,GO:0031113,GO:0031116,GO:0031122,GO:0031334,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031981,GO:0032271,GO:0032273,GO:0032501,GO:0032502,GO:0032507,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0032886,GO:0032940,GO:0033036,GO:0033043,GO:0033365,GO:0034260,GO:0034329,GO:0034330,GO:0034332,GO:0034333,GO:0034504,GO:0034613,GO:0034622,GO:0035639,GO:0036094,GO:0036445,GO:0036465,GO:0040001,GO:0042221,GO:0042493,GO:0043086,GO:0043087,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043297,GO:0043622,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044430,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045165,GO:0045185,GO:0045196,GO:0045216,GO:0045785,GO:0046660,GO:0046883,GO:0046903,GO:0048103,GO:0048488,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048608,GO:0048699,GO:0048731,GO:0048806,GO:0048856,GO:0048869,GO:0050708,GO:0050789,GO:0050790,GO:0050794,GO:0050796,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051130,GO:0051179,GO:0051223,GO:0051234,GO:0051235,GO:0051293,GO:0051294,GO:0051301,GO:0051336,GO:0051346,GO:0051457,GO:0051493,GO:0051495,GO:0051640,GO:0051641,GO:0051649,GO:0051651,GO:0051653,GO:0051656,GO:0055057,GO:0055059,GO:0060589,GO:0061351,GO:0061458,GO:0061640,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070161,GO:0070201,GO:0070507,GO:0070727,GO:0070830,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072089,GO:0072595,GO:0090087,GO:0090276,GO:0097159,GO:0097367,GO:0097435,GO:0098657,GO:0098722,GO:0098772,GO:0098916,GO:0099003,GO:0099080,GO:0099504,GO:0099536,GO:0099537,GO:0099643,GO:1901265,GO:1901363,GO:1901374,GO:1902850,GO:1902903,GO:1902905,GO:1903047,GO:1903530	-	ko:K07943,ko:K21596	-	-	-	-	ko00000,ko03000,ko03036,ko04031	-	-	-	Arf
WLSH3_k127_377115_2	84531.JMTZ01000018_gene3881	6.285e-07	62.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_377115_0	304371.MCP_1854	2.576e-46	180.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
WLSH3_k127_377115_1	926554.KI912669_gene5027	3.143e-28	127.0	COG4805@1|root,COG4805@2|Bacteria,1WM4J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3787056_2	195522.BD01_1057	8.574e-30	128.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2436S@183968|Thermococci	183968|Thermococci	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_3787056_1	264732.Moth_0153	6.096e-34	136.0	COG1142@1|root,COG1142@2|Bacteria,1VH83@1239|Firmicutes,24TVN@186801|Clostridia,42JCX@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_4,Fer4_7
WLSH3_k127_3787056_0	574087.Acear_1487	9.402e-109	370.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_3808419_0	311424.DhcVS_118	1.484e-20	101.0	COG3568@1|root,COG3568@2|Bacteria,2G7ER@200795|Chloroflexi,34CM1@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
WLSH3_k127_3811566_7	264731.PRU_0532	9.319e-15	84.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA,AAA_32,AAA_5,CHAT,Lon_C,NB-ARC,TPR_12
WLSH3_k127_3811566_5	1349822.NSB1T_02890	1.462e-33	148.0	COG2304@1|root,COG2304@2|Bacteria,4P02M@976|Bacteroidetes,2FX22@200643|Bacteroidia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
WLSH3_k127_3811566_2	272844.PAB1737	2.821e-96	324.0	COG0543@1|root,arCOG02199@2157|Archaea,2XTVJ@28890|Euryarchaeota,243NE@183968|Thermococci	183968|Thermococci	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	1.8.1.19	ko:K20203	-	-	-	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind
WLSH3_k127_3811566_0	1121335.Clst_0501	7.724e-197	623.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WGEA@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
WLSH3_k127_3811566_1	444157.Tneu_1126	4.562e-110	376.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
WLSH3_k127_3811566_6	192952.MM_0598	4.069e-20	102.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
WLSH3_k127_3811566_4	374847.Kcr_1233	1.439e-41	162.0	COG2129@1|root,arCOG01147@2157|Archaea	2157|Archaea	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
WLSH3_k127_3811566_3	444158.MmarC6_1459	1.884e-42	160.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_3846394_0	523845.AQXV01000055_gene71	4.327e-31	140.0	COG1002@1|root,arCOG02634@2157|Archaea,arCOG02635@2157|Archaea,2Y89W@28890|Euryarchaeota,23R3Q@183939|Methanococci	183939|Methanococci	L	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase,TaqI_C
WLSH3_k127_3852787_2	1123389.ATXJ01000004_gene1325	0.0002198	49.0	COG0642@1|root,COG2205@2|Bacteria,1WJF3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,TPR_16,TPR_19,TPR_2
WLSH3_k127_3852787_0	1365176.N186_02405	9.263e-62	219.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
WLSH3_k127_3852787_1	868131.MSWAN_1901	1.71e-34	139.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota	28890|Euryarchaeota	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
WLSH3_k127_3864327_1	926569.ANT_16930	1.035e-65	239.0	COG2234@1|root,COG2234@2|Bacteria,2G6WJ@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
WLSH3_k127_3864327_2	326427.Cagg_1814	1.852e-29	130.0	COG2319@1|root,COG2909@1|root,COG2319@2|Bacteria,COG2909@2|Bacteria,2G86V@200795|Chloroflexi,374S2@32061|Chloroflexia	32061|Chloroflexia	KLT	WD-40 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,WD40
WLSH3_k127_3864327_0	1451189.CFAL_03035	1.025e-81	280.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,22K6P@1653|Corynebacteriaceae	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
WLSH3_k127_3864327_3	411460.RUMTOR_00910	3.243e-05	50.0	2DX7X@1|root,32V2Y@2|Bacteria,1VB4V@1239|Firmicutes,254MP@186801|Clostridia,3Y083@572511|Blautia	186801|Clostridia	S	COG NOG38524 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3880214_0	243232.MJ_0619	1.155e-152	499.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
WLSH3_k127_3888541_2	742818.HMPREF9451_01679	6.468e-05	51.0	COG3402@1|root,COG3402@2|Bacteria,2GSY6@201174|Actinobacteria,4CVS9@84998|Coriobacteriia	84998|Coriobacteriia	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
WLSH3_k127_3888541_1	456442.Mboo_0952	2.494e-10	69.0	arCOG04915@1|root,arCOG04915@2157|Archaea,2Y3CG@28890|Euryarchaeota,2NAQQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3888541_0	208439.AJAP_37585	3.489e-13	76.0	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria,4DY1J@85010|Pseudonocardiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
WLSH3_k127_3893590_1	604354.TSIB_0222	2.272e-97	336.0	COG1840@1|root,arCOG00221@2157|Archaea,2Y33A@28890|Euryarchaeota,243E5@183968|Thermococci	183968|Thermococci	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
WLSH3_k127_3893590_0	391623.TERMP_01190	2.191e-115	397.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,242Z4@183968|Thermococci	183968|Thermococci	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
WLSH3_k127_389973_2	1285586.H131_19222	8.049e-12	69.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4HEMY@91061|Bacilli,3IZ74@400634|Lysinibacillus	91061|Bacilli	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_389973_1	1455608.JDTH01000006_gene2617	1.144e-13	77.0	COG3439@1|root,arCOG02761@2157|Archaea,2XZR9@28890|Euryarchaeota,23WSC@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
WLSH3_k127_389973_0	521045.Kole_1186	8.405e-23	108.0	COG1670@1|root,COG1670@2|Bacteria,2GCZ2@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
WLSH3_k127_3927024_1	1120971.AUCA01000027_gene703	6.277e-30	127.0	COG0644@1|root,COG0644@2|Bacteria,1U3SW@1239|Firmicutes,4HSRK@91061|Bacilli	91061|Bacilli	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_3
WLSH3_k127_3927024_2	877455.Metbo_1610	7.525e-19	91.0	COG1695@1|root,arCOG00001@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_3927024_0	292459.STH2369	1.05e-56	205.0	COG0500@1|root,COG2226@2|Bacteria,1U5XV@1239|Firmicutes,24A44@186801|Clostridia	186801|Clostridia	Q	Methyltransferase	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
WLSH3_k127_3927689_6	406327.Mevan_1345	9.901e-33	134.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23QQD@183939|Methanococci	183939|Methanococci	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
WLSH3_k127_3927689_5	868131.MSWAN_2029	9.318e-40	155.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23P09@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
WLSH3_k127_3927689_8	589924.Ferp_1598	2.127e-20	98.0	COG1853@1|root,arCOG02017@2157|Archaea,2XXYS@28890|Euryarchaeota,247HG@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
WLSH3_k127_3927689_2	634498.mru_1053	8.381e-81	279.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
WLSH3_k127_3927689_10	523850.TON_0649	8.55e-14	74.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
WLSH3_k127_3927689_11	877455.Metbo_1975	7.123e-08	61.0	arCOG06453@1|root,arCOG06453@2157|Archaea,2XZAX@28890|Euryarchaeota,23P5V@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3927689_4	224324.aq_403	1.193e-66	243.0	COG1856@1|root,COG1856@2|Bacteria	2|Bacteria	S	radical SAM domain protein	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
WLSH3_k127_3927689_0	1343739.PAP_05870	4.736e-118	396.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
WLSH3_k127_3927689_3	272844.PAB2113	2.284e-72	252.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,242R3@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
WLSH3_k127_3927689_1	573063.Metin_0747	1.933e-84	289.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,23Q8C@183939|Methanococci	183939|Methanococci	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
WLSH3_k127_3927689_7	1042375.AFPL01000026_gene3542	7.706e-29	121.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_3927689_9	338963.Pcar_0379	7.335e-20	93.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,43RZJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	mglA	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
WLSH3_k127_3928714_0	243232.MJ_0436	4.126e-99	342.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,23QBR@183939|Methanococci	183939|Methanococci	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
WLSH3_k127_3928714_1	1118054.CAGW01000062_gene2268	1.171e-83	289.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4H9MS@91061|Bacilli,26QTF@186822|Paenibacillaceae	91061|Bacilli	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010,ko:K17240	ko02010,map02010	M00190,M00599	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.38,3.A.1.10	-	-	ABC_tran,TOBE_2
WLSH3_k127_3940354_0	529818.AMSG_02797T0	1.072e-13	78.0	KOG0394@1|root,KOG0394@2759|Eukaryota	2759|Eukaryota	K	GTPase activity	-	-	-	ko:K07897	ko04137,ko04138,ko04140,ko04144,ko04145,ko05132,ko05146,ko05152,map04137,map04138,map04140,map04144,map04145,map05132,map05146,map05152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras,Roc
WLSH3_k127_3950145_1	1121422.AUMW01000025_gene323	2.329e-09	60.0	COG1960@1|root,COG1960@2|Bacteria,1TRR9@1239|Firmicutes,24AJB@186801|Clostridia,260H9@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_3950145_0	399549.Msed_1437	9.142e-15	80.0	COG1146@1|root,arCOG04548@2157|Archaea	2157|Archaea	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
WLSH3_k127_3982326_1	339860.Msp_0762	1.004e-10	76.0	arCOG02487@1|root,arCOG02547@1|root,arCOG02487@2157|Archaea,arCOG02547@2157|Archaea,2Y29V@28890|Euryarchaeota,23PFX@183925|Methanobacteria	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,CarboxypepD_reg
WLSH3_k127_3982326_2	272569.rrnAC1026	1.256e-09	70.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
WLSH3_k127_3982326_0	195522.BD01_1777	1.448e-76	265.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WLSH3_k127_4004275_2	521674.Plim_1218	4.924e-10	68.0	28JE3@1|root,2Z98B@2|Bacteria,2J0PD@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4004275_0	243232.MJ_1192	4.91e-131	432.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23QHR@183939|Methanococci	183939|Methanococci	C	PFAM Nickel-dependent hydrogenase, large subunit	vhuA	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
WLSH3_k127_4004275_1	267377.MMP0822	1.601e-50	187.0	COG1941@1|root,arCOG02472@2157|Archaea,2XV6A@28890|Euryarchaeota,23QG6@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
WLSH3_k127_4024409_0	255470.cbdbA481	3.169e-12	76.0	COG0620@1|root,COG0620@2|Bacteria,2G8QD@200795|Chloroflexi,34D53@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4026386_6	298655.KI912266_gene243	1.45e-09	64.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria,4EUG7@85013|Frankiales	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
WLSH3_k127_4026386_2	1408254.T458_02780	7.646e-58	214.0	COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,4HABM@91061|Bacilli,26T9J@186822|Paenibacillaceae	91061|Bacilli	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0042802,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
WLSH3_k127_4026386_5	436308.Nmar_0114	1.368e-32	137.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,TrmB
WLSH3_k127_4026386_3	666510.ASAC_0588	6.422e-51	186.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
WLSH3_k127_4026386_0	710696.Intca_3130	7.973e-93	317.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FJQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
WLSH3_k127_4026386_1	374847.Kcr_1556	6.648e-66	240.0	COG0624@1|root,arCOG01107@2157|Archaea	2157|Archaea	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_4026386_4	749414.SBI_01756	4.624e-36	147.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
WLSH3_k127_4026386_7	7955.ENSDARP00000051549	2.373e-08	60.0	KOG0443@1|root,KOG0443@2759|Eukaryota,38QM1@33154|Opisthokonta,3B9JY@33208|Metazoa,3D0D6@33213|Bilateria,47YVF@7711|Chordata,48X58@7742|Vertebrata,49Z7R@7898|Actinopterygii	33208|Metazoa	Z	Capping protein (actin filament), gelsolin-like b	CAPG	GO:0002376,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0005815,GO:0005819,GO:0005856,GO:0006950,GO:0006952,GO:0006955,GO:0008064,GO:0008150,GO:0008290,GO:0009987,GO:0010033,GO:0010639,GO:0015629,GO:0015630,GO:0016043,GO:0019904,GO:0022607,GO:0030030,GO:0030031,GO:0030139,GO:0030496,GO:0030832,GO:0030833,GO:0030834,GO:0030835,GO:0030837,GO:0031333,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032271,GO:0032272,GO:0032535,GO:0032956,GO:0032970,GO:0032991,GO:0033043,GO:0034097,GO:0034341,GO:0042221,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043242,GO:0043244,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044450,GO:0044464,GO:0044877,GO:0045087,GO:0045335,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051016,GO:0051128,GO:0051129,GO:0051493,GO:0051494,GO:0051693,GO:0051716,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071310,GO:0071345,GO:0071346,GO:0071840,GO:0072686,GO:0090066,GO:0090543,GO:0097708,GO:0110053,GO:1901879,GO:1901880,GO:1902903,GO:1902904	-	ko:K10368	-	-	-	-	ko00000,ko04147,ko04812	-	-	-	Gelsolin
WLSH3_k127_4031456_0	1343740.M271_45085	1.799e-06	61.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter (Permease)	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_4099959_2	1120978.KB894086_gene507	9.286e-28	126.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,27F72@186828|Carnobacteriaceae	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_4099959_1	1254432.SCE1572_32355	1.754e-33	135.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WP23@28221|Deltaproteobacteria,2Z0GF@29|Myxococcales	28221|Deltaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WLSH3_k127_4099959_3	990073.ATHU01000001_gene1302	5.188e-19	92.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Belongs to the thioredoxin family	trx2	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH3_k127_4099959_4	1427984.X271_00197	1.949e-14	78.0	COG3118@1|root,COG3118@2|Bacteria,3WTYZ@544448|Tenericutes	544448|Tenericutes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH3_k127_4099959_0	1229909.NSED_07310	2.814e-100	347.0	COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
WLSH3_k127_411091_5	1341151.ASZU01000006_gene2870	6.789e-10	68.0	COG2318@1|root,COG2318@2|Bacteria,1V6FD@1239|Firmicutes,4HJI8@91061|Bacilli,27C7I@186824|Thermoactinomycetaceae	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
WLSH3_k127_411091_7	1236508.BAKF01000011_gene1142	1.472e-07	59.0	COG2461@1|root,COG2461@2|Bacteria,4NJQA@976|Bacteroidetes	976|Bacteroidetes	S	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,Hemerythrin,PAS_10
WLSH3_k127_411091_1	386456.JQKN01000017_gene846	1.212e-62	222.0	COG4832@1|root,arCOG03571@1|root,arCOG03201@2157|Archaea,arCOG03571@2157|Archaea,2Y3NU@28890|Euryarchaeota	28890|Euryarchaeota	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
WLSH3_k127_411091_0	945713.IALB_1230	1.281e-64	230.0	COG0121@1|root,COG0121@2|Bacteria	2|Bacteria	S	cellular modified histidine biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,GATase_4,Transglut_core
WLSH3_k127_411091_4	439481.Aboo_0134	7.904e-15	87.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_411091_3	202752.JL53_02495	3.382e-22	108.0	COG4886@1|root,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,4HM8K@91061|Bacilli,26K84@186820|Listeriaceae	91061|Bacilli	M	Leucine-rich repeat (LRR) protein	inlA	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030260,GO:0030312,GO:0035635,GO:0044403,GO:0044409,GO:0044419,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944	-	ko:K13730,ko:K13731	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Cu_amine_oxidN1,Flg_new,Gram_pos_anchor,Internalin_N,LRR_4,LRR_6,LRR_adjacent,NEAT,SLH,Strep_his_triad,fn3
WLSH3_k127_411091_2	891968.Anamo_0321	2.033e-23	106.0	COG1283@1|root,COG1283@2|Bacteria,3T9ZW@508458|Synergistetes	508458|Synergistetes	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
WLSH3_k127_4115862_0	548477.HMPREF0294_0332	6.578e-71	274.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
WLSH3_k127_4119144_3	929506.CbC4_2451	7.52e-11	68.0	COG1082@1|root,COG1082@2|Bacteria,1V56C@1239|Firmicutes,24D55@186801|Clostridia,36I65@31979|Clostridiaceae	186801|Clostridia	L	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_4119144_1	635013.TherJR_2506	2.426e-23	109.0	COG0500@1|root,COG2226@2|Bacteria,1V6QV@1239|Firmicutes,24JPQ@186801|Clostridia,267C0@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
WLSH3_k127_4119144_0	5334.XP_003028257.1	3.272e-68	241.0	COG1028@1|root,KOG1200@2759|Eukaryota,39KUT@33154|Opisthokonta,3Q584@4751|Fungi,3V7AR@5204|Basidiomycota	4751|Fungi	Q	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
WLSH3_k127_4132604_3	1120946.AUBF01000011_gene1809	5.12e-07	61.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4D5ND@85005|Actinomycetales	201174|Actinobacteria	K	Ribosomal-protein-alanine acetyltransferase	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_4132604_0	269797.Mbar_A3389	1.466e-50	186.0	COG0535@1|root,arCOG00955@2157|Archaea,2Y8D1@28890|Euryarchaeota,2NASP@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
WLSH3_k127_4132604_1	1122927.KB895413_gene1795	1.708e-49	186.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,4HC44@91061|Bacilli,26QCB@186822|Paenibacillaceae	91061|Bacilli	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	mtnU	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
WLSH3_k127_4132604_2	56780.SYN_02213	9.505e-10	67.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
WLSH3_k127_4138004_1	76869.PputGB1_3105	1.932e-22	101.0	2C625@1|root,2ZD1M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_413949_0	933262.AXAM01000035_gene2154	5.889e-57	211.0	2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria,2MNT8@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_413949_1	304371.MCP_1435	1.11e-38	156.0	COG2202@1|root,arCOG03931@1|root,arCOG06712@1|root,arCOG03931@2157|Archaea,arCOG06538@2157|Archaea,arCOG06712@2157|Archaea,2Y3TD@28890|Euryarchaeota,2NAV1@224756|Methanomicrobia	224756|Methanomicrobia	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
WLSH3_k127_413949_2	1122917.KB899672_gene821	1.85e-35	147.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,4HJIN@91061|Bacilli,26RB8@186822|Paenibacillaceae	91061|Bacilli	-	-	M1-693	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
WLSH3_k127_413949_3	5722.XP_001316606.1	2.799e-18	92.0	COG1100@1|root,KOG0086@2759|Eukaryota	2759|Eukaryota	Q	regulation of endocytosis	-	-	-	-	-	-	-	-	-	-	-	-	Ras
WLSH3_k127_413949_4	868131.MSWAN_1145	0.0001815	45.0	COG1149@1|root,arCOG04073@2157|Archaea	2157|Archaea	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
WLSH3_k127_4158836_1	368408.Tpen_0043	5.284e-68	250.0	COG1530@1|root,arCOG00321@2157|Archaea,2XQ2D@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_4158836_0	351160.RCIX2261	5.499e-127	420.0	arCOG03315@1|root,arCOG03315@2157|Archaea,2Y2NW@28890|Euryarchaeota,2NACC@224756|Methanomicrobia	224756|Methanomicrobia	S	DUF3160	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160
WLSH3_k127_4176261_7	926569.ANT_19730	2.125e-06	55.0	COG1647@1|root,COG1647@2|Bacteria,2G909@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha beta hydrolase fold	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
WLSH3_k127_4176261_1	986075.CathTA2_0103	1.418e-66	237.0	COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli	91061|Bacilli	S	Belongs to the SOS response-associated peptidase family	yoqW	-	-	-	-	-	-	-	-	-	-	-	SRAP
WLSH3_k127_4176261_8	28377.ENSACAP00000014041	2.377e-05	55.0	COG4886@1|root,KOG0619@2759|Eukaryota,39T1E@33154|Opisthokonta,3BCA4@33208|Metazoa,3CU35@33213|Bilateria,487G8@7711|Chordata,493DA@7742|Vertebrata	33208|Metazoa	T	Insulin-like growth factor-binding protein complex acid labile	Nepn	GO:0000122,GO:0005575,GO:0005576,GO:0005614,GO:0005615,GO:0006355,GO:0006357,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0016043,GO:0017015,GO:0019219,GO:0019222,GO:0023051,GO:0023057,GO:0030198,GO:0030512,GO:0031012,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043062,GO:0044421,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0062023,GO:0065007,GO:0071840,GO:0080090,GO:0090092,GO:0090101,GO:0090287,GO:0090288,GO:1902679,GO:1903506,GO:1903507,GO:1903844,GO:1903845,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	LRR_5,LRR_8
WLSH3_k127_4176261_0	1131266.ARWQ01000001_gene1364	1.643e-155	503.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
WLSH3_k127_4176261_4	351160.RCIX2041	1.912e-21	97.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,2N9YA@224756|Methanomicrobia	224756|Methanomicrobia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
WLSH3_k127_4176261_9	1459636.NTE_01468	0.0004688	46.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
WLSH3_k127_4176261_3	1184251.TCELL_0130	1.66e-25	108.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
WLSH3_k127_4176261_5	269797.Mbar_A1568	1.585e-16	80.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
WLSH3_k127_4176261_2	1343739.PAP_03440	2.574e-61	220.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,243FV@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
WLSH3_k127_4176261_6	1041930.Mtc_m4	3.246e-10	62.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,2NA3J@224756|Methanomicrobia	224756|Methanomicrobia	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
WLSH3_k127_4207603_0	877455.Metbo_2113	3.506e-82	282.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_4207603_2	877455.Metbo_2112	1.352e-55	203.0	COG0479@1|root,arCOG00962@2157|Archaea,2XSXW@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
WLSH3_k127_4207603_1	880073.Calab_2008	3.122e-66	239.0	COG2189@1|root,COG2189@2|Bacteria,2NP0F@2323|unclassified Bacteria	2|Bacteria	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
WLSH3_k127_4237701_0	272844.PAB2313	9.557e-174	572.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,24373@183968|Thermococci	183968|Thermococci	L	helicase superfamily c-terminal domain	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
WLSH3_k127_4242924_0	429009.Adeg_0355	1.432e-90	311.0	COG1180@1|root,COG1180@2|Bacteria,1V170@1239|Firmicutes,24E3W@186801|Clostridia,42HNZ@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_4242924_1	868131.MSWAN_1553	4.654e-51	186.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
WLSH3_k127_4242924_3	456320.Mvol_0794	1.092e-08	58.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_4242924_2	1168034.FH5T_09810	5.139e-09	57.0	COG0109@1|root,COG0109@2|Bacteria,4NF5A@976|Bacteroidetes	976|Bacteroidetes	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
WLSH3_k127_4252920_0	404380.Gbem_1790	4.648e-17	94.0	COG0438@1|root,COG0438@2|Bacteria,1RHQ2@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
WLSH3_k127_4252920_1	643473.KB235930_gene330	1.752e-16	85.0	COG0438@1|root,COG0438@2|Bacteria,1G32B@1117|Cyanobacteria,1HQ1N@1161|Nostocales	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_4309812_0	756883.Halar_1331	9.817e-14	75.0	COG0006@1|root,arCOG01000@2157|Archaea	2157|Archaea	E	Belongs to the peptidase M24B family	pepQ1	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_4309812_2	330084.JNYZ01000009_gene6401	9.011e-07	59.0	COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4E0XV@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_4311521_3	395965.Msil_0873	7.388e-05	50.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,3NC9N@45404|Beijerinckiaceae	28211|Alphaproteobacteria	EGP	MFS_1 like family	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
WLSH3_k127_4311521_2	457421.CBFG_02841	5.491e-13	74.0	COG1695@1|root,COG1695@2|Bacteria,1VAGB@1239|Firmicutes,24MZ2@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, PadR family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
WLSH3_k127_4311521_1	1209989.TepiRe1_0379	3.817e-40	157.0	COG1751@1|root,COG1751@2|Bacteria,1V1CN@1239|Firmicutes,24G0M@186801|Clostridia,42G89@68295|Thermoanaerobacterales	186801|Clostridia	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
WLSH3_k127_4311521_0	1396418.BATQ01000184_gene2567	3.501e-92	314.0	COG0484@1|root,COG0484@2|Bacteria,46TKC@74201|Verrucomicrobia,2ITUR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
WLSH3_k127_43231_0	69293.ENSGACP00000008046	9.672e-55	203.0	COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,47ZN8@7711|Chordata,498TD@7742|Vertebrata,4A16Y@7898|Actinopterygii	33208|Metazoa	E	Si dkey-103j14.5	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
WLSH3_k127_43231_1	86416.Clopa_1099	2.03e-22	106.0	COG0500@1|root,COG2226@2|Bacteria,1UI7M@1239|Firmicutes,24E0D@186801|Clostridia,36N6N@31979|Clostridiaceae	186801|Clostridia	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
WLSH3_k127_43231_2	660470.Theba_0404	8.884e-18	93.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_4326112_6	1260251.SPISAL_06100	8.191e-05	48.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,1SCIW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ICC-like phosphoesterases	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
WLSH3_k127_4326112_4	296587.XP_002503713.1	2.93e-06	54.0	2AM4V@1|root,2RZB5@2759|Eukaryota,37U4I@33090|Viridiplantae,34ISB@3041|Chlorophyta	3041|Chlorophyta	S	Zinc finger SWIM domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
WLSH3_k127_4326112_2	523845.AQXV01000053_gene666	6.542e-37	147.0	COG0218@1|root,arCOG00355@2157|Archaea,2XTV8@28890|Euryarchaeota,23QRQ@183939|Methanococci	183939|Methanococci	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
WLSH3_k127_4326112_0	304371.MCP_0129	2.495e-193	636.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
WLSH3_k127_4326112_5	439481.Aboo_0015	4.603e-06	51.0	arCOG05717@1|root,arCOG05717@2157|Archaea,2Y77I@28890|Euryarchaeota,3F3IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4326112_3	273063.STK_03080	5.977e-14	74.0	COG4888@1|root,arCOG04136@2157|Archaea,2XR0Q@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
WLSH3_k127_4326112_1	1236689.MMALV_07230	3.17e-72	253.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota	2157|Archaea	E	Cysteine desulfurase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
WLSH3_k127_4331754_3	485913.Krac_10173	6.028e-25	114.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	-	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
WLSH3_k127_4331754_2	477974.Daud_0825	3.286e-39	154.0	COG0560@1|root,COG0560@2|Bacteria,1VCP5@1239|Firmicutes,24AF0@186801|Clostridia,265KV@186807|Peptococcaceae	186801|Clostridia	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
WLSH3_k127_4331754_4	439481.Aboo_0097	1.9e-06	60.0	COG0530@1|root,arCOG02881@2157|Archaea,2XVHN@28890|Euryarchaeota,3F388@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	K -dependent Na Ca exchanger	-	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
WLSH3_k127_4331754_0	926569.ANT_19900	1.178e-102	346.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_4331754_1	477974.Daud_1208	1.616e-99	339.0	COG1239@1|root,COG1239@2|Bacteria,1UHYK@1239|Firmicutes,24BJ0@186801|Clostridia,2609Y@186807|Peptococcaceae	186801|Clostridia	H	PFAM magnesium chelatase	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase,VWA_2
WLSH3_k127_4339283_0	877455.Metbo_0444	2.879e-22	104.0	COG2232@1|root,arCOG01595@2157|Archaea,2XVAH@28890|Euryarchaeota,23P2I@183925|Methanobacteria	183925|Methanobacteria	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
WLSH3_k127_4392526_0	529709.PYCH_12090	4.196e-44	171.0	COG1063@1|root,arCOG01459@2157|Archaea,2Y683@28890|Euryarchaeota,2450G@183968|Thermococci	183968|Thermococci	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_4392526_1	444157.Tneu_1313	1.603e-34	145.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
WLSH3_k127_4392526_2	572478.Vdis_0984	0.0009645	43.0	arCOG05489@1|root,arCOG05489@2157|Archaea,2XQT5@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4412316_1	1719.CPTC_01868	1.724e-14	74.0	COG1249@1|root,COG1249@2|Bacteria,2GNSR@201174|Actinobacteria,22JKS@1653|Corynebacteriaceae	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	mtr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0010126,GO:0016137,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050627,GO:0050660,GO:0050661,GO:0050662,GO:0051186,GO:0055114,GO:0070402,GO:0071704,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901657	1.8.1.15	ko:K17883	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
WLSH3_k127_4412316_0	1365176.N186_00730	2.387e-67	237.0	COG1249@1|root,arCOG01068@2157|Archaea,2XPKZ@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
WLSH3_k127_4438315_1	477184.KYC_02029	1.138e-45	178.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2W96Q@28216|Betaproteobacteria,3T7AI@506|Alcaligenaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
WLSH3_k127_4438315_0	644966.Tmar_1068	1.086e-61	226.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,3WD6Z@538999|Clostridiales incertae sedis	186801|Clostridia	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
WLSH3_k127_4438434_2	272844.PAB1877	1.587e-10	63.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,242ZU@183968|Thermococci	183968|Thermococci	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
WLSH3_k127_4438434_3	374847.Kcr_1446	2.95e-07	61.0	COG3390@1|root,arCOG02258@2157|Archaea	2157|Archaea	S	protein conserved in archaea	rpap1	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	tRNA_anti-codon
WLSH3_k127_4438434_0	420247.Msm_0511	4.946e-29	120.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,23P0P@183925|Methanobacteria	183925|Methanobacteria	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
WLSH3_k127_4438434_1	593117.TGAM_0853	1.065e-18	90.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,244B2@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
WLSH3_k127_4468335_3	1071085.KK033114_gene1361	2.382e-25	117.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,23S7X@183963|Halobacteria	183963|Halobacteria	J	NMD protein affecting ribosome stability and mRNA decay	nmd3	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
WLSH3_k127_4468335_2	647113.Metok_1149	1.268e-33	134.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23QZQ@183939|Methanococci	183939|Methanococci	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
WLSH3_k127_4468335_0	351160.LRC287	2.822e-63	227.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
WLSH3_k127_4468335_1	604354.TSIB_1106	8.394e-44	166.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,24319@183968|Thermococci	183968|Thermococci	J	Pfam:KH_3	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
WLSH3_k127_4468335_4	490899.DKAM_1219	8.31e-19	90.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
WLSH3_k127_4481854_0	693661.Arcve_1580	1.629e-41	168.0	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,2461Y@183980|Archaeoglobi	183980|Archaeoglobi	P	Chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
WLSH3_k127_4512977_5	1267535.KB906767_gene667	2.729e-07	62.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.7.8.20	ko:K01002,ko:K20534	ko01100,map01100	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	GT87,Glycos_transf_2
WLSH3_k127_4512977_1	397948.Cmaq_0619	2.762e-38	152.0	COG0463@1|root,arCOG00894@2157|Archaea,2XQ9U@28889|Crenarchaeota	28889|Crenarchaeota	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
WLSH3_k127_4512977_4	90814.KL370891_gene565	1.755e-10	71.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,460IF@72273|Thiotrichales	72273|Thiotrichales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
WLSH3_k127_4512977_3	269482.Bcep1808_5944	3.206e-17	83.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2VVZH@28216|Betaproteobacteria,1KA6B@119060|Burkholderiaceae	28216|Betaproteobacteria	O	hydrogenase expression formation protein	hypC1	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
WLSH3_k127_4512977_2	698757.Pogu_1512	5.491e-25	108.0	COG2250@1|root,arCOG01191@2157|Archaea	2157|Archaea	F	PFAM HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
WLSH3_k127_4512977_6	572478.Vdis_0982	2.187e-06	55.0	COG1708@1|root,arCOG01204@2157|Archaea,2XS32@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
WLSH3_k127_4512977_0	368408.Tpen_0881	1.994e-57	203.0	COG1313@1|root,arCOG00934@2157|Archaea,2XPK3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_4516496_3	383372.Rcas_3275	4.091e-07	61.0	COG2304@1|root,COG2304@2|Bacteria,2G82P@200795|Chloroflexi,374S6@32061|Chloroflexia	32061|Chloroflexia	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
WLSH3_k127_4516496_2	1121428.DESHY_60109___1	1.127e-10	74.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261PU@186807|Peptococcaceae	186801|Clostridia	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
WLSH3_k127_4516496_0	1201288.M900_1553	9.393e-69	256.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2MSTI@213481|Bdellovibrionales,2WJDZ@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
WLSH3_k127_4516496_1	526224.Bmur_2691	2.212e-14	87.0	COG4485@1|root,COG5617@1|root,COG4485@2|Bacteria,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
WLSH3_k127_4528280_2	351160.RCIX2452	1.117e-06	52.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map-1	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WLSH3_k127_4528280_0	374847.Kcr_1153	3.123e-89	309.0	COG4046@1|root,arCOG04181@2157|Archaea	2157|Archaea	S	DUF1512 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
WLSH3_k127_4528280_1	246969.TAM4_1895	3.864e-54	197.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
WLSH3_k127_4530551_0	224325.AF_2100	2.801e-173	555.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,245VB@183980|Archaeoglobi	28890|Euryarchaeota	E	Acetolactate synthase, large subunit	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
WLSH3_k127_4530551_2	1220534.B655_1160	9.181e-30	126.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
WLSH3_k127_4530551_3	1324957.K933_09432	4.169e-22	109.0	COG4552@1|root,arCOG10664@2157|Archaea,2XTW3@28890|Euryarchaeota,23S97@183963|Halobacteria	183963|Halobacteria	S	acetyltransferase involved in intracellular survival and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
WLSH3_k127_4530551_4	880073.Calab_1834	7.863e-15	85.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
WLSH3_k127_4530551_1	224325.AF_1752	5.967e-31	126.0	COG1070@1|root,arCOG00025@2157|Archaea,2Y7I2@28890|Euryarchaeota	28890|Euryarchaeota	G	Belongs to the FGGY kinase family	-	-	2.7.1.17,2.7.1.53	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00014	R01639,R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_4536976_1	717231.Flexsi_0638	7.484e-05	49.0	COG3875@1|root,COG3875@2|Bacteria,2GEKZ@200930|Deferribacteres	200930|Deferribacteres	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
WLSH3_k127_4536976_0	1382304.JNIL01000001_gene1376	5.132e-99	335.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4H9W6@91061|Bacilli	91061|Bacilli	G	Belongs to the FGGY kinase family	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_4551579_0	1047013.AQSP01000134_gene1338	1.194e-101	347.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
WLSH3_k127_4556286_0	1089548.KI783301_gene2505	1.81e-202	653.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,4HAI0@91061|Bacilli,3WEIM@539002|Bacillales incertae sedis	91061|Bacilli	P	E1-E2 ATPase	copA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH3_k127_4562554_0	208439.AJAP_13905	1.901e-36	151.0	COG4990@1|root,COG4990@2|Bacteria,2GQ07@201174|Actinobacteria,4DXNX@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
WLSH3_k127_4572724_7	877455.Metbo_0791	1.9e-24	105.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,23PAC@183925|Methanobacteria	183925|Methanobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
WLSH3_k127_4572724_6	768679.TTX_1822	1.004e-25	119.0	COG1717@1|root,arCOG00781@2157|Archaea,2XQI2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
WLSH3_k127_4572724_4	70601.3258190	3.23e-32	130.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,243Y0@183968|Thermococci	183968|Thermococci	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
WLSH3_k127_4572724_2	384616.Pisl_1868	3.658e-48	183.0	COG0256@1|root,arCOG04088@2157|Archaea,2XPNF@28889|Crenarchaeota	28889|Crenarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
WLSH3_k127_4572724_1	933801.Ahos_0864	6.15e-70	243.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
WLSH3_k127_4572724_3	224719.Abm4_1255	4.677e-38	147.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,23P1Y@183925|Methanobacteria	183925|Methanobacteria	J	ribosomal protein	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
WLSH3_k127_4572724_5	768672.Desfe_0971	2.579e-31	129.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
WLSH3_k127_4572724_8	339860.Msp_0886	4.899e-19	93.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,23PMG@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	-	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
WLSH3_k127_4572724_9	84751.XP_007879011.1	0.0002586	47.0	COG5029@1|root,KOG0366@2759|Eukaryota,38DTQ@33154|Opisthokonta,3NTZW@4751|Fungi,3UZ5B@5204|Basidiomycota,3N4X0@452284|Ustilaginomycotina	4751|Fungi	O	Prenyltransferase and squalene oxidase repeat	BET2	GO:0003674,GO:0003824,GO:0004659,GO:0004661,GO:0004663,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005968,GO:0006464,GO:0006605,GO:0006612,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0008104,GO:0008150,GO:0008152,GO:0008270,GO:0008318,GO:0009987,GO:0015031,GO:0015833,GO:0016192,GO:0016740,GO:0016765,GO:0017016,GO:0017137,GO:0018342,GO:0018344,GO:0019538,GO:0019899,GO:0031267,GO:0032991,GO:0033036,GO:0034613,GO:0036211,GO:0042886,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046872,GO:0046907,GO:0046914,GO:0048193,GO:0051020,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0072657,GO:0072659,GO:0090150,GO:0097354,GO:0140096,GO:1901564,GO:1902494,GO:1990234,GO:1990778	2.5.1.60	ko:K05956	-	-	-	-	ko00000,ko01000,ko01006,ko04131	-	-	-	Prenyltrans
WLSH3_k127_4572724_0	5833.MAL13P1.231	5.489e-107	364.0	COG0201@1|root,KOG1373@2759|Eukaryota,3Y9GN@5794|Apicomplexa,3KBK8@422676|Aconoidasida,3YYHJ@5819|Haemosporida	422676|Aconoidasida	U	Plug domain of Sec61p	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K10956	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Plug_translocon,SecY
WLSH3_k127_4610034_1	273057.SSO2555	3.83e-36	144.0	arCOG06048@1|root,arCOG06048@2157|Archaea,2XSAG@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4610034_0	639282.DEFDS_0513	1.613e-79	274.0	COG0428@1|root,COG0428@2|Bacteria,2GFCI@200930|Deferribacteres	200930|Deferribacteres	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
WLSH3_k127_4610221_2	351160.RCIX1797	6.505e-38	160.0	arCOG02559@1|root,arCOG02559@2157|Archaea,2XZ97@28890|Euryarchaeota,2NB2X@224756|Methanomicrobia	224756|Methanomicrobia	M	by modhmm	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4610221_1	273057.SSO2555	1.063e-39	156.0	arCOG06048@1|root,arCOG06048@2157|Archaea,2XSAG@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4610221_0	639282.DEFDS_0513	1.613e-79	274.0	COG0428@1|root,COG0428@2|Bacteria,2GFCI@200930|Deferribacteres	200930|Deferribacteres	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
WLSH3_k127_4625309_0	1125863.JAFN01000001_gene929	1.055e-153	501.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
WLSH3_k127_463704_0	1343739.PAP_02030	1.264e-66	233.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
WLSH3_k127_463704_2	694429.Pyrfu_0825	1.596e-18	91.0	COG1325@1|root,arCOG01042@2157|Archaea,2XQSI@28889|Crenarchaeota	28889|Crenarchaeota	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
WLSH3_k127_463704_5	1261545.MBE-HAL_1704	1.493e-12	77.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,23TGE@183963|Halobacteria	183963|Halobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
WLSH3_k127_463704_7	186497.PF1378	7.52e-06	52.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2445Q@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
WLSH3_k127_463704_3	444157.Tneu_1283	1.92e-18	90.0	COG1310@1|root,arCOG01138@2157|Archaea,2XRGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
WLSH3_k127_463704_4	1134413.ANNK01000031_gene1437	1.401e-15	82.0	COG1522@1|root,COG1522@2|Bacteria,1V72S@1239|Firmicutes,4HJS3@91061|Bacilli,1ZGCT@1386|Bacillus	91061|Bacilli	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_463704_1	439481.Aboo_0292	6.854e-54	201.0	COG3294@1|root,arCOG04230@2157|Archaea,2XURZ@28890|Euryarchaeota,3F2ZC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_463704_6	269799.Gmet_1663	2.347e-07	63.0	COG0477@1|root,COG2814@2|Bacteria,1QUAS@1224|Proteobacteria,431FD@68525|delta/epsilon subdivisions,2WWTD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_4654722_1	572546.Arcpr_0590	4.36e-41	162.0	COG0383@1|root,arCOG03661@2157|Archaea,2XVNX@28890|Euryarchaeota	28890|Euryarchaeota	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
WLSH3_k127_4654722_0	368408.Tpen_0304	2.765e-223	704.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
WLSH3_k127_4713385_2	877415.JNJQ01000002_gene2457	1.638e-10	68.0	COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,3VRN0@526524|Erysipelotrichia	526524|Erysipelotrichia	L	GIY-YIG catalytic domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Desulfoferrodox,GIY-YIG
WLSH3_k127_4713385_1	1463903.JOIZ01000003_gene1743	2.421e-13	75.0	COG3255@1|root,COG3255@2|Bacteria	2|Bacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_4713385_3	1230457.C476_17427	6.142e-05	47.0	COG1063@1|root,arCOG01459@2157|Archaea,2XUT4@28890|Euryarchaeota,23UCI@183963|Halobacteria	183963|Halobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_4722763_0	1304284.L21TH_2417	7.401e-20	106.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,36HXX@31979|Clostridiaceae	186801|Clostridia	M	Subtilase family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
WLSH3_k127_4748815_1	415426.Hbut_1212	3.26e-44	165.0	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
WLSH3_k127_4748815_3	65393.PCC7424_4737	0.0006882	51.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,3KHSB@43988|Cyanothece	1117|Cyanobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_4748815_2	374847.Kcr_0495	1.329e-37	149.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_IclR,TrmB
WLSH3_k127_4748815_0	1184251.TCELL_0795	6.325e-61	216.0	COG0017@1|root,arCOG00407@2157|Archaea,2XQ0M@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
WLSH3_k127_4766047_0	1121422.AUMW01000013_gene1531	8.693e-40	152.0	COG0475@1|root,COG0475@2|Bacteria,1TVA8@1239|Firmicutes,25A6J@186801|Clostridia,2647C@186807|Peptococcaceae	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
WLSH3_k127_4766047_1	1283299.AUKG01000003_gene359	7.236e-13	79.0	COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,4CQXK@84995|Rubrobacteria	84995|Rubrobacteria	T	COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms	-	-	-	-	-	-	-	-	-	-	-	-	Usp
WLSH3_k127_4810263_0	1353528.DT23_18220	1.68e-142	469.0	COG3950@1|root,COG3950@2|Bacteria,1MUE9@1224|Proteobacteria	1224|Proteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
WLSH3_k127_4812454_2	269797.Mbar_A0881	1.58e-21	100.0	COG1035@1|root,COG3350@1|root,arCOG02650@2157|Archaea,arCOG04507@2157|Archaea,2Y7JA@28890|Euryarchaeota,2NAMA@224756|Methanomicrobia	224756|Methanomicrobia	C	YHS domain	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N,YHS
WLSH3_k127_4812454_1	1192034.CAP_6745	3.398e-72	251.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	-	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
WLSH3_k127_4812454_0	1365176.N186_08995	3.112e-86	301.0	COG4690@1|root,arCOG03602@2157|Archaea,2XRTU@28889|Crenarchaeota	28889|Crenarchaeota	E	Peptidase family C69	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
WLSH3_k127_4815840_1	1198232.CYCME_1450	1.845e-36	154.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,1RXH8@1236|Gammaproteobacteria,4633T@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_4815840_0	1229780.BN381_130329	8.793e-90	305.0	COG1091@1|root,COG1091@2|Bacteria,2HG64@201174|Actinobacteria,3UXQ6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	RmlD_sub_bind
WLSH3_k127_482870_1	1288494.EBAPG3_18060	2.919e-15	86.0	COG0110@1|root,COG0110@2|Bacteria,1RBYA@1224|Proteobacteria,2VRA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
WLSH3_k127_482870_0	456320.Mvol_1689	1.194e-21	108.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,23QRM@183939|Methanococci	183939|Methanococci	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,HI0933_like
WLSH3_k127_4836515_0	1349822.NSB1T_12810	3.14e-142	468.0	COG2189@1|root,COG2189@2|Bacteria,4NHTG@976|Bacteroidetes,2FQKU@200643|Bacteroidia,22YMU@171551|Porphyromonadaceae	976|Bacteroidetes	L	DNA methylase	-	-	2.1.1.72	ko:K00571,ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MerR,N6_N4_Mtase
WLSH3_k127_4836515_1	1167006.UWK_00583	3.8e-29	122.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
WLSH3_k127_4838288_1	903818.KI912269_gene285	4.041e-38	148.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	BBE,FAD_binding_4
WLSH3_k127_4838288_0	903818.KI912269_gene284	2.25e-101	345.0	COG0247@1|root,COG0247@2|Bacteria,3Y3RK@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
WLSH3_k127_4838288_2	903818.KI912269_gene283	2.333e-14	76.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_4849859_0	1487923.DP73_01915	7.135e-33	144.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,260J4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_4853948_0	439235.Dalk_2834	2.945e-32	142.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,43B2Q@68525|delta/epsilon subdivisions,2WK38@28221|Deltaproteobacteria,2MJTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_4853948_1	1536774.H70357_01210	5.645e-20	100.0	28IEB@1|root,2Z8GD@2|Bacteria,1VCER@1239|Firmicutes,4I70C@91061|Bacilli,26VR2@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037
WLSH3_k127_488341_0	639282.DEFDS_0470	6.766e-84	285.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GEZG@200930|Deferribacteres	200930|Deferribacteres	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
WLSH3_k127_488341_2	401526.TcarDRAFT_2312	2.119e-34	148.0	COG1409@1|root,COG1409@2|Bacteria,1VDYM@1239|Firmicutes	1239|Firmicutes	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
WLSH3_k127_488341_1	351160.LRC325	1.192e-53	201.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	ABC_cobalt,Oxidored_molyb
WLSH3_k127_4884097_0	1280001.BAOA01000007_gene3919	0.0004016	54.0	COG2911@1|root,COG2911@2|Bacteria,1R2WA@1224|Proteobacteria,1T5YU@1236|Gammaproteobacteria,1XY4V@135623|Vibrionales	135623|Vibrionales	S	Invasin, domain 3	-	-	-	-	-	-	-	-	-	-	-	-	Invasin_D3
WLSH3_k127_4901965_0	868131.MSWAN_0358	5.797e-109	365.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
WLSH3_k127_4901965_1	877455.Metbo_0715	1.195e-92	318.0	COG1032@1|root,arCOG01355@2157|Archaea,2XUPV@28890|Euryarchaeota,23NTW@183925|Methanobacteria	183925|Methanobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_4910986_0	192952.MM_1844	6.982e-88	303.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2N92Q@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
WLSH3_k127_4910986_1	304371.MCP_0281	4.914e-34	147.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,2N96T@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_4923605_2	453591.Igni_1184	4.631e-44	169.0	COG1867@1|root,arCOG01219@2157|Archaea,2XPQJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
WLSH3_k127_4923605_0	1185876.BN8_04452	7.498e-51	184.0	COG0652@1|root,COG0652@2|Bacteria,4NKQ7@976|Bacteroidetes,47P72@768503|Cytophagia	976|Bacteroidetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
WLSH3_k127_4923605_1	1128421.JAGA01000003_gene2815	1.327e-46	179.0	COG1082@1|root,COG1082@2|Bacteria,2NRRT@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_4925219_2	1121090.KB894699_gene4166	2.469e-06	58.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_4925219_1	1227497.C491_18469	4.882e-71	254.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,23TKY@183963|Halobacteria	183963|Halobacteria	E	Belongs to the peptidase M24B family	pepQ1	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_4925219_3	178306.PAE2987	2.93e-05	53.0	COG0727@1|root,arCOG02579@2157|Archaea,2XR8B@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WLSH3_k127_4925219_0	1121440.AUMA01000011_gene2309	1.125e-218	698.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
WLSH3_k127_4962921_2	933262.AXAM01000037_gene875	4.069e-14	74.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ00@28221|Deltaproteobacteria,2MJIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_4962921_1	69279.BG36_23425	1.85e-20	93.0	COG0236@1|root,COG0236@2|Bacteria,1NC80@1224|Proteobacteria,2UU7U@28211|Alphaproteobacteria,43RH8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Acyl carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
WLSH3_k127_4962921_4	864051.BurJ1DRAFT_1685	0.0003898	47.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_4962921_0	909663.KI867150_gene1592	1.941e-101	341.0	COG0171@1|root,COG0171@2|Bacteria,1QHZ4@1224|Proteobacteria,42QD8@68525|delta/epsilon subdivisions,2WMK9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
WLSH3_k127_4962921_3	1291050.JAGE01000001_gene65	2.205e-06	50.0	COG0037@1|root,COG0037@2|Bacteria,1V113@1239|Firmicutes,24CE8@186801|Clostridia	186801|Clostridia	D	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4977444_2	386456.JQKN01000010_gene620	3.926e-05	48.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
WLSH3_k127_4977444_0	309799.DICTH_1698	2.565e-116	383.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
WLSH3_k127_4977444_1	1121011.AUCB01000035_gene869	1.497e-19	104.0	COG1524@1|root,COG1524@2|Bacteria,4NIUS@976|Bacteroidetes,1HZKJ@117743|Flavobacteriia,23HQN@178469|Arenibacter	976|Bacteroidetes	S	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,PA14,Phosphodiest
WLSH3_k127_4980737_2	1395513.P343_10460	1.048e-11	75.0	COG0842@1|root,COG0842@2|Bacteria,1TT5K@1239|Firmicutes,4HGJI@91061|Bacilli	91061|Bacilli	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
WLSH3_k127_4980737_1	865861.AZSU01000001_gene386	6.529e-27	122.0	COG0842@1|root,COG0842@2|Bacteria,1VI3K@1239|Firmicutes,24AR2@186801|Clostridia,36F7U@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
WLSH3_k127_4980737_0	1280692.AUJL01000002_gene2736	3.649e-73	258.0	COG1131@1|root,COG1131@2|Bacteria,1UHTY@1239|Firmicutes,24JZH@186801|Clostridia,36UHX@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_4992285_0	509191.AEDB02000019_gene4456	1.448e-18	101.0	2DUFI@1|root,33QET@2|Bacteria,1VTMU@1239|Firmicutes,24ZIK@186801|Clostridia,3WMZX@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5023586_0	1042877.GQS_10515	1.781e-39	169.0	COG1800@1|root,arCOG07561@1|root,arCOG02164@2157|Archaea,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota,2435K@183968|Thermococci	183968|Thermococci	K	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
WLSH3_k127_5026244_1	760192.Halhy_2265	9.031e-47	178.0	COG2319@1|root,COG2319@2|Bacteria,4NKC3@976|Bacteroidetes,1J18Y@117747|Sphingobacteriia	976|Bacteroidetes	C	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
WLSH3_k127_5026244_2	45157.CMF181CT	1.499e-30	128.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	RAB1A	GO:0000003,GO:0000045,GO:0000139,GO:0000149,GO:0000166,GO:0000278,GO:0000280,GO:0000281,GO:0000407,GO:0000902,GO:0000904,GO:0000910,GO:0001816,GO:0001882,GO:0001883,GO:0002790,GO:0002791,GO:0002793,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005768,GO:0005769,GO:0005773,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005795,GO:0005801,GO:0005802,GO:0005829,GO:0005886,GO:0005911,GO:0006139,GO:0006401,GO:0006464,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006890,GO:0006897,GO:0006900,GO:0006901,GO:0006903,GO:0006906,GO:0006914,GO:0006928,GO:0006950,GO:0006952,GO:0006996,GO:0007017,GO:0007018,GO:0007030,GO:0007033,GO:0007049,GO:0007112,GO:0007140,GO:0007154,GO:0007155,GO:0007165,GO:0007264,GO:0007265,GO:0007267,GO:0007275,GO:0007276,GO:0007399,GO:0008088,GO:0008089,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009306,GO:0009506,GO:0009555,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009893,GO:0009894,GO:0009914,GO:0009932,GO:0009966,GO:0009987,GO:0010035,GO:0010038,GO:0010256,GO:0010506,GO:0010604,GO:0010646,GO:0010647,GO:0010720,GO:0010769,GO:0010770,GO:0010817,GO:0010970,GO:0010975,GO:0010976,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016043,GO:0016049,GO:0016050,GO:0016070,GO:0016192,GO:0016197,GO:0016236,GO:0016241,GO:0016462,GO:0016477,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0019001,GO:0019058,GO:0019068,GO:0019220,GO:0019222,GO:0019439,GO:0019538,GO:0019953,GO:0022008,GO:0022402,GO:0022406,GO:0022411,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023056,GO:0023061,GO:0030054,GO:0030072,GO:0030133,GO:0030154,GO:0030252,GO:0030334,GO:0030658,GO:0030659,GO:0030705,GO:0030742,GO:0031090,GO:0031323,GO:0031325,GO:0031329,GO:0031344,GO:0031346,GO:0031396,GO:0031398,GO:0031399,GO:0031401,GO:0031410,GO:0031589,GO:0031982,GO:0031984,GO:0032024,GO:0032029,GO:0032036,GO:0032153,GO:0032154,GO:0032155,GO:0032258,GO:0032268,GO:0032270,GO:0032400,GO:0032401,GO:0032402,GO:0032456,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032588,GO:0032637,GO:0032879,GO:0032880,GO:0032940,GO:0032984,GO:0032989,GO:0033036,GO:0033043,GO:0033059,GO:0033116,GO:0033206,GO:0033365,GO:0033500,GO:0034045,GO:0034067,GO:0034446,GO:0034497,GO:0034498,GO:0034613,GO:0034622,GO:0034641,GO:0034655,GO:0035459,GO:0035493,GO:0035494,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0040007,GO:0040011,GO:0040012,GO:0042147,GO:0042175,GO:0042221,GO:0042325,GO:0042470,GO:0042592,GO:0042742,GO:0042886,GO:0043025,GO:0043085,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043473,GO:0043549,GO:0043624,GO:0043687,GO:0043933,GO:0044085,GO:0044087,GO:0044088,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044297,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044464,GO:0044703,GO:0044706,GO:0045184,GO:0045202,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046483,GO:0046686,GO:0046700,GO:0046879,GO:0046883,GO:0046887,GO:0046903,GO:0046907,GO:0047496,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0048211,GO:0048229,GO:0048232,GO:0048278,GO:0048284,GO:0048285,GO:0048468,GO:0048518,GO:0048522,GO:0048583,GO:0048588,GO:0048589,GO:0048609,GO:0048699,GO:0048731,GO:0048770,GO:0048814,GO:0048856,GO:0048868,GO:0048869,GO:0048870,GO:0048878,GO:0050663,GO:0050708,GO:0050714,GO:0050767,GO:0050769,GO:0050773,GO:0050775,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050796,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051094,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051270,GO:0051301,GO:0051321,GO:0051338,GO:0051347,GO:0051438,GO:0051443,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051668,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0051875,GO:0051904,GO:0051905,GO:0051960,GO:0051962,GO:0055044,GO:0060255,GO:0060284,GO:0060560,GO:0061024,GO:0061025,GO:0061640,GO:0061709,GO:0061912,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070382,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072384,GO:0072606,GO:0072657,GO:0072665,GO:0072741,GO:0080090,GO:0080115,GO:0080134,GO:0080135,GO:0090087,GO:0090110,GO:0090114,GO:0090174,GO:0090276,GO:0090277,GO:0090304,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098542,GO:0098588,GO:0098590,GO:0098657,GO:0098791,GO:0098793,GO:0098805,GO:0098827,GO:0098930,GO:0099111,GO:0099503,GO:0099518,GO:0120035,GO:0140013,GO:0140056,GO:1900006,GO:1900101,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901575,GO:1902115,GO:1903008,GO:1903018,GO:1903020,GO:1903046,GO:1903047,GO:1903320,GO:1903322,GO:1903530,GO:1903532,GO:1904666,GO:1904668,GO:1904951,GO:1905037,GO:1905345,GO:1905897,GO:1990261,GO:1990778,GO:2000026,GO:2000145,GO:2000785	1.3.5.6	ko:K00514,ko:K03354,ko:K07874,ko:K07875	ko00906,ko01100,ko01110,ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05134,ko05166,map00906,map01100,map01110,map04110,map04111,map04113,map04114,map04120,map04914,map05134,map05166	M00097,M00389	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000,ko03036,ko04031,ko04121,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_5026244_3	1448860.BBJO01000052_gene4	1.432e-09	63.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XXYB@28890|Euryarchaeota,23WG9@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5026244_0	1459636.NTE_00007	4.856e-87	307.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
WLSH3_k127_5027879_2	118005.AWNK01000003_gene2423	0.0002515	52.0	COG5362@1|root,COG5362@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
WLSH3_k127_5027879_1	665950.HMPREF1025_01359	1.228e-07	62.0	COG5362@1|root,COG5362@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
WLSH3_k127_5027879_0	369723.Strop_0517	6.456e-63	225.0	2EES9@1|root,338JX@2|Bacteria,2H5MY@201174|Actinobacteria	201174|Actinobacteria	L	RNase_H superfamily	-	-	-	-	-	-	-	-	-	-	-	-	RNase_H_2
WLSH3_k127_5036513_3	7918.ENSLOCP00000014021	0.0002011	54.0	KOG4423@1|root,KOG4423@2759|Eukaryota,39VT3@33154|Opisthokonta,3BGAJ@33208|Metazoa,3CTWI@33213|Bilateria,484PF@7711|Chordata,490TM@7742|Vertebrata,4A3QY@7898|Actinopterygii	33208|Metazoa	U	RAB29, member RAS oncogene family	RAB29	GO:0000166,GO:0001775,GO:0001882,GO:0001883,GO:0001919,GO:0001921,GO:0002376,GO:0002682,GO:0002684,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005768,GO:0005769,GO:0005794,GO:0005801,GO:0005802,GO:0006810,GO:0006996,GO:0007005,GO:0007030,GO:0007275,GO:0007399,GO:0007416,GO:0008092,GO:0008104,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010256,GO:0010604,GO:0010646,GO:0010647,GO:0010721,GO:0010941,GO:0010975,GO:0010977,GO:0012505,GO:0016032,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017016,GO:0017076,GO:0017111,GO:0017137,GO:0018995,GO:0019001,GO:0019003,GO:0019058,GO:0019079,GO:0019222,GO:0019894,GO:0019899,GO:0020003,GO:0022008,GO:0022607,GO:0023051,GO:0023056,GO:0030030,GO:0030031,GO:0030154,GO:0030430,GO:0031267,GO:0031323,GO:0031325,GO:0031344,GO:0031345,GO:0031410,GO:0031982,GO:0031984,GO:0032386,GO:0032388,GO:0032438,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0033036,GO:0033059,GO:0033157,GO:0033365,GO:0033643,GO:0033646,GO:0033655,GO:0034613,GO:0035639,GO:0036094,GO:0039694,GO:0042110,GO:0042147,GO:0042470,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043230,GO:0043231,GO:0043473,GO:0043656,GO:0043657,GO:0044085,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044419,GO:0044421,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0044766,GO:0044782,GO:0044877,GO:0045321,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0046649,GO:0046907,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048699,GO:0048731,GO:0048753,GO:0048770,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050808,GO:0050854,GO:0050856,GO:0050857,GO:0050862,GO:0050896,GO:0051020,GO:0051049,GO:0051050,GO:0051093,GO:0051128,GO:0051129,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051241,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051960,GO:0051961,GO:0055037,GO:0060255,GO:0060271,GO:0060284,GO:0060341,GO:0060627,GO:0061512,GO:0065007,GO:0065010,GO:0070201,GO:0070727,GO:0070840,GO:0070925,GO:0071840,GO:0072657,GO:0090087,GO:0090316,GO:0097159,GO:0097367,GO:0097708,GO:0098791,GO:0120031,GO:0120035,GO:0120036,GO:1901214,GO:1901265,GO:1901363,GO:1901998,GO:1902579,GO:1903441,GO:1903649,GO:1903827,GO:1903829,GO:1904951,GO:1905279,GO:1990778,GO:1990967,GO:2000026	-	ko:K07916	-	-	-	-	ko00000,ko04031	-	-	-	Ras
WLSH3_k127_5036513_0	573063.Metin_0714	2.63e-67	239.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,23QHW@183939|Methanococci	183939|Methanococci	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
WLSH3_k127_5036513_1	706587.Desti_5187	5.292e-52	194.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,42RKW@68525|delta/epsilon subdivisions,2X5I8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
WLSH3_k127_5036513_2	634498.mru_0949	4.367e-41	165.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV39@28890|Euryarchaeota,23PDN@183925|Methanobacteria	183925|Methanobacteria	P	Substrate binding domain of ABC-type glycine betaine transport system	btcC	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
WLSH3_k127_5040256_0	1170562.Cal6303_3252	3.539e-27	113.0	COG0455@1|root,COG0455@2|Bacteria,1G1EJ@1117|Cyanobacteria,1HQDQ@1161|Nostocales	1117|Cyanobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,ParA
WLSH3_k127_5045609_2	1233951.IO90_01130	0.0004875	53.0	COG1541@1|root,COG1541@2|Bacteria,4NGRR@976|Bacteroidetes,1HZ2J@117743|Flavobacteriia,3HGQ7@358033|Chryseobacterium	976|Bacteroidetes	H	AMP-binding enzyme	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
WLSH3_k127_5045609_1	1370122.JHXQ01000026_gene165	3.812e-06	51.0	COG1522@1|root,COG1522@2|Bacteria,1MZDV@1224|Proteobacteria,2UBTU@28211|Alphaproteobacteria,4BG46@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Lrp/AsnC ligand binding domain	QU41_18010	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
WLSH3_k127_5045609_0	926550.CLDAP_22150	1.654e-11	68.0	COG1694@1|root,COG1694@2|Bacteria	2|Bacteria	FG	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
WLSH3_k127_5046112_0	192952.MM_0835	4.754e-150	505.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAFK@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
WLSH3_k127_5071594_0	1499967.BAYZ01000132_gene306	9.481e-64	239.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_5071594_1	633148.Tagg_0698	5.165e-22	98.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_5081125_2	1041930.Mtc_0528	5.537e-31	138.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
WLSH3_k127_5081125_1	1131266.ARWQ01000006_gene219	2.176e-76	273.0	COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WLSH3_k127_5081125_0	323259.Mhun_1112	5.048e-90	309.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
WLSH3_k127_5092975_3	35128.Thaps2376	1.312e-74	259.0	COG1577@1|root,KOG1511@2759|Eukaryota,2XDVQ@2836|Bacillariophyta	2836|Bacillariophyta	I	GHMP kinases C terminal	-	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
WLSH3_k127_5092975_2	523850.TON_0392	1.798e-92	319.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
WLSH3_k127_5092975_1	877455.Metbo_0105	6.497e-100	340.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23NR8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
WLSH3_k127_5092975_9	456442.Mboo_1457	3.544e-37	143.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
WLSH3_k127_5092975_4	399550.Smar_0820	1.327e-70	244.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
WLSH3_k127_5092975_14	1183377.Py04_1524	4.642e-23	102.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
WLSH3_k127_5092975_7	634498.mru_0911	7.679e-40	151.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
WLSH3_k127_5092975_10	186497.PF1645	5.818e-32	129.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
WLSH3_k127_5092975_12	246969.TAM4_22	5.537e-29	119.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2444E@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
WLSH3_k127_5092975_5	1041930.Mtc_1534	6.622e-68	241.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
WLSH3_k127_5092975_16	8090.ENSORLP00000023124	8.278e-11	70.0	COG1100@1|root,KOG0070@2759|Eukaryota,38D1T@33154|Opisthokonta,3BN8W@33208|Metazoa,3CWE4@33213|Bilateria,486JF@7711|Chordata,495RS@7742|Vertebrata,4A2ST@7898|Actinopterygii	33208|Metazoa	U	Belongs to the small GTPase superfamily. Arf family	ARL11	GO:0002244,GO:0002376,GO:0002520,GO:0007275,GO:0008150,GO:0009987,GO:0030097,GO:0030154,GO:0032501,GO:0032502,GO:0048513,GO:0048534,GO:0048731,GO:0048856,GO:0048869	-	ko:K07959	-	-	-	-	ko00000,ko04031	-	-	-	Arf
WLSH3_k127_5092975_6	453591.Igni_1174	3.279e-43	170.0	COG0371@1|root,arCOG00982@2157|Archaea,2XPMJ@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
WLSH3_k127_5092975_8	195522.BD01_0617	8.38e-38	145.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
WLSH3_k127_5092975_13	1163730.FFONT_0450	8.291e-27	110.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
WLSH3_k127_5092975_15	330779.Saci_0697	8.051e-15	76.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
WLSH3_k127_5092975_11	429009.Adeg_2058	8.538e-31	130.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,24JM5@186801|Clostridia,42G92@68295|Thermoanaerobacterales	186801|Clostridia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
WLSH3_k127_5092975_0	453591.Igni_0001	1.32e-190	612.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
WLSH3_k127_5122006_0	529818.AMSG_03083T0	2.501e-33	134.0	KOG0080@1|root,KOG0080@2759|Eukaryota	2759|Eukaryota	S	myosin XI tail binding	RAB18	GO:0000166,GO:0001654,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006810,GO:0006887,GO:0006913,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008092,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0030141,GO:0030659,GO:0030667,GO:0030742,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032029,GO:0032036,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032940,GO:0034389,GO:0035556,GO:0036094,GO:0036230,GO:0042119,GO:0042175,GO:0042579,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0080115,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098827,GO:0099503,GO:1901265,GO:1901363	3.1.3.16	ko:K07910,ko:K07976,ko:K17506	-	-	-	-	ko00000,ko01000,ko01009,ko04031,ko04131	-	-	-	Ras
WLSH3_k127_5122006_1	215803.DB30_3947	3.16e-08	67.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,430Q8@68525|delta/epsilon subdivisions,2WVYQ@28221|Deltaproteobacteria,2YU06@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
WLSH3_k127_512215_0	304371.MCP_2717	1.116e-29	119.0	COG1088@1|root,arCOG01371@2157|Archaea,2XUZX@28890|Euryarchaeota,2N94H@224756|Methanomicrobia	224756|Methanomicrobia	M	Male sterility protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
WLSH3_k127_512215_1	357808.RoseRS_1103	2.346e-29	128.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.243	ko:K16215	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
WLSH3_k127_5176373_0	192952.MM_2931	1.453e-83	290.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
WLSH3_k127_5176373_1	246969.TAM4_1403	8.406e-08	56.0	COG0681@1|root,arCOG01739@2157|Archaea,2XYEA@28890|Euryarchaeota,24456@183968|Thermococci	183968|Thermococci	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
WLSH3_k127_5218590_0	1329516.JPST01000025_gene2209	7.339e-31	134.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,4HBYM@91061|Bacilli,27BP3@186824|Thermoactinomycetaceae	91061|Bacilli	L	endonuclease III	yfjP	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
WLSH3_k127_5218590_2	29495.EA26_09150	2.147e-05	56.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XT9F@135623|Vibrionales	135623|Vibrionales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_5218590_1	880070.Cycma_1421	7.835e-06	51.0	COG1266@1|root,COG1266@2|Bacteria,4NHE1@976|Bacteroidetes,47JZ8@768503|Cytophagia	976|Bacteroidetes	S	PFAM CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_5225966_7	374847.Kcr_0315	0.0009088	51.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3,Sugar_tr
WLSH3_k127_5225966_5	926550.CLDAP_15430	8.214e-14	83.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
WLSH3_k127_5225966_1	351160.RCIX954	1.17e-51	189.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,2N9QW@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
WLSH3_k127_5225966_3	368408.Tpen_1001	3.356e-39	155.0	COG1194@1|root,arCOG00462@2157|Archaea,2XQQC@28889|Crenarchaeota	28889|Crenarchaeota	L	endonuclease III	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
WLSH3_k127_5225966_2	1365176.N186_09045	9.463e-41	160.0	COG2820@1|root,arCOG01324@2157|Archaea,2XPX2@28889|Crenarchaeota	1365176.N186_09045|-	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	-
WLSH3_k127_5225966_6	323259.Mhun_2553	1.122e-06	58.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2NA25@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
WLSH3_k127_5225966_0	1121342.AUCO01000004_gene608	3.441e-91	308.0	COG0863@1|root,COG0863@2|Bacteria,1TR56@1239|Firmicutes,248NR@186801|Clostridia	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
WLSH3_k127_5225966_4	1894.JOER01000069_gene7187	1.358e-18	90.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3
WLSH3_k127_5227795_1	572546.Arcpr_1284	0.0001792	48.0	COG0526@1|root,arCOG02713@2157|Archaea	2157|Archaea	C	Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0055114	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
WLSH3_k127_5227795_0	572546.Arcpr_0010	1.339e-111	377.0	COG1328@1|root,COG2074@1|root,arCOG01967@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,NRDD
WLSH3_k127_524505_1	374847.Kcr_1128	1.957e-75	268.0	COG1530@1|root,arCOG00321@2157|Archaea	2157|Archaea	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_524505_2	477974.Daud_1002	8.259e-58	218.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_524505_0	186497.PF1380	3.162e-131	441.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,24339@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
WLSH3_k127_5251411_2	1184251.TCELL_0403	1.443e-16	82.0	COG0012@1|root,arCOG00357@2157|Archaea,2XPTY@28889|Crenarchaeota	28889|Crenarchaeota	J	GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
WLSH3_k127_5251411_1	760568.Desku_1009	7.982e-52	190.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,2620R@186807|Peptococcaceae	186801|Clostridia	S	DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
WLSH3_k127_5251411_0	1041930.Mtc_0048	3.852e-88	301.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
WLSH3_k127_5277485_0	926561.KB900619_gene2409	0.0002146	49.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5281920_1	5850.PKH_112130	1.382e-14	75.0	COG0720@1|root,2S1HP@2759|Eukaryota,3YBTA@5794|Apicomplexa,3KENM@422676|Aconoidasida,3YZK9@5819|Haemosporida	422676|Aconoidasida	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.60,4.2.3.12	ko:K22101	ko00790,map00790	M00841	R04286,R11719	RC01117	ko00000,ko00001,ko00002,ko01000	-	-	-	PTPS
WLSH3_k127_5281920_0	368408.Tpen_0750	1.227e-161	528.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
WLSH3_k127_5281920_2	593117.TGAM_0855	1.398e-14	76.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,244GA@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
WLSH3_k127_5295589_1	1459636.NTE_01641	1.161e-17	94.0	arCOG03119@1|root,arCOG03119@2157|Archaea,41SMJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WLSH3_k127_5295589_0	887929.HMP0721_1535	1.652e-22	111.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,25V9P@186806|Eubacteriaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
WLSH3_k127_5334316_3	357808.RoseRS_4528	6.89e-09	61.0	COG1669@1|root,COG1669@2|Bacteria,2G9YQ@200795|Chloroflexi,377C1@32061|Chloroflexia	32061|Chloroflexia	L	PFAM DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
WLSH3_k127_5334316_1	941824.TCEL_02217	1.618e-15	82.0	COG2445@1|root,COG2445@2|Bacteria,1VF87@1239|Firmicutes,24HS2@186801|Clostridia,36IYH@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
WLSH3_k127_5334316_0	1123277.KB893181_gene2301	2.564e-83	284.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.23	ko:K01054	ko00561,ko01100,ko04714,ko04723,ko04923,map00561,map01100,map04714,map04723,map04923	M00098	R01351	RC00020,RC00041	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Hydrolase_4
WLSH3_k127_5334316_2	500153.JOEK01000009_gene5062	1.21e-10	64.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_5337851_0	1192034.CAP_6268	4.883e-47	179.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2YU6C@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
WLSH3_k127_5337851_1	1121904.ARBP01000003_gene6367	6.595e-06	58.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,4NF2C@976|Bacteroidetes,47S41@768503|Cytophagia	976|Bacteroidetes	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
WLSH3_k127_5350434_0	589865.DaAHT2_1245	1.328e-226	715.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MI0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
WLSH3_k127_5350434_1	1206741.BAFX01000098_gene4520	3.267e-15	84.0	COG5316@1|root,COG5316@2|Bacteria,2GN81@201174|Actinobacteria,4FZQT@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
WLSH3_k127_5367690_0	1122986.KB908319_gene395	1.587e-33	141.0	COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,2FM38@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
WLSH3_k127_5367690_1	266117.Rxyl_2862	7.945e-06	55.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CSW8@84995|Rubrobacteria	84995|Rubrobacteria	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WLSH3_k127_5371430_0	1304875.JAFZ01000001_gene971	3.397e-33	146.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_5371430_1	572547.Amico_1777	2.927e-07	57.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_5413563_0	243231.GSU1222	1.609e-76	268.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,43TQX@69541|Desulfuromonadales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
WLSH3_k127_5413563_1	2074.JNYD01000046_gene7292	4.961e-06	57.0	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria,4DXYS@85010|Pseudonocardiales	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
WLSH3_k127_5424707_2	1382358.JHVN01000001_gene815	8.983e-06	57.0	COG0346@1|root,COG0346@2|Bacteria,1V6SC@1239|Firmicutes,4HCP5@91061|Bacilli,21WXK@150247|Anoxybacillus	91061|Bacilli	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
WLSH3_k127_5424707_0	1041930.Mtc_1495	5.985e-59	213.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,2N9M4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
WLSH3_k127_5424707_1	367737.Abu_1061	1.069e-07	61.0	COG0697@1|root,COG0697@2|Bacteria,1PIFB@1224|Proteobacteria,42QAN@68525|delta/epsilon subdivisions,2YNGI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	EG	integral membrane protein (DUF6 domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_5440262_1	416591.Tlet_0046	1.14e-21	100.0	COG2211@1|root,COG2211@2|Bacteria,2GDVW@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
WLSH3_k127_5440262_0	771875.Ferpe_1310	5.887e-78	268.0	COG0778@1|root,COG0778@2|Bacteria,2GCST@200918|Thermotogae	200918|Thermotogae	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_5440262_2	342949.PNA2_0585	1.945e-18	94.0	COG0308@1|root,arCOG02969@2157|Archaea,2Y343@28890|Euryarchaeota,2445R@183968|Thermococci	183968|Thermococci	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
WLSH3_k127_5467960_1	1121468.AUBR01000028_gene1527	8.755e-27	113.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42I2K@68295|Thermoanaerobacterales	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_5467960_0	93220.LV28_08565	1.21e-60	217.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJF5@28216|Betaproteobacteria,1K5AA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
WLSH3_k127_5467960_2	304371.MCP_2261	3.11e-11	68.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYAZ@28890|Euryarchaeota,2N9WV@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_5481000_0	70601.3258422	7.528e-18	91.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,243A6@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
WLSH3_k127_5481000_1	1198449.ACAM_1459	2.236e-12	72.0	COG0636@1|root,arCOG02455@2157|Archaea,2XR87@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase proteolipid subunit family	atpP	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
WLSH3_k127_5481000_2	1540257.JQMW01000009_gene2992	8.329e-09	67.0	COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia,36HA3@31979|Clostridiaceae	186801|Clostridia	C	ATPase subunit C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
WLSH3_k127_5481000_3	1121289.JHVL01000002_gene2386	6.092e-07	57.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,36DMW@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
WLSH3_k127_550594_0	269797.Mbar_A2589	9.329e-82	295.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,2N9AI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
WLSH3_k127_550594_2	351160.LRC437	2.5e-69	250.0	COG1148@1|root,arCOG02236@2157|Archaea,2XV85@28890|Euryarchaeota,2NABC@224756|Methanomicrobia	224756|Methanomicrobia	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3	ko:K22480	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
WLSH3_k127_550594_1	243232.MJ_0863	7.767e-72	252.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_550594_8	706587.Desti_0171	1.202e-26	117.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
WLSH3_k127_550594_12	1459636.NTE_00425	0.0001598	51.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
WLSH3_k127_550594_3	1365176.N186_04465	1.786e-47	188.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
WLSH3_k127_550594_5	391623.TERMP_00342	2.82e-37	150.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2434V@183968|Thermococci	183968|Thermococci	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N,Rad1
WLSH3_k127_550594_9	1151117.AJLF01000001_gene1107	1.941e-24	106.0	COG1594@1|root,arCOG00579@2157|Archaea,2XZ6S@28890|Euryarchaeota,245HK@183968|Thermococci	183968|Thermococci	K	RNA polymerase subunit 9	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
WLSH3_k127_550594_10	69014.TK1166	1.388e-13	76.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
WLSH3_k127_550594_11	868131.MSWAN_2282	4.171e-13	72.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
WLSH3_k127_550594_7	453591.Igni_0577	8.089e-27	119.0	COG1096@1|root,arCOG00676@2157|Archaea,2XQRA@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,S1
WLSH3_k127_550594_4	1041930.Mtc_1738	1.818e-42	164.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,2N9NN@224756|Methanomicrobia	224756|Methanomicrobia	Q	methyltransferase small	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
WLSH3_k127_550594_6	1094980.Mpsy_1728	1.285e-34	138.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
WLSH3_k127_5521288_1	96561.Dole_2862	4.329e-06	57.0	COG0406@1|root,COG0406@2|Bacteria,1RD8S@1224|Proteobacteria,42RWY@68525|delta/epsilon subdivisions,2WNIA@28221|Deltaproteobacteria,2MK2F@213118|Desulfobacterales	28221|Deltaproteobacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WLSH3_k127_5521288_0	439481.Aboo_0843	6.745e-63	236.0	COG1173@1|root,arCOG00748@2157|Archaea,2XVZA@28890|Euryarchaeota,3F300@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_5542504_0	1120968.AUBX01000012_gene2712	1.915e-24	119.0	COG2866@1|root,COG2866@2|Bacteria,4NIJ0@976|Bacteroidetes,47K8F@768503|Cytophagia	976|Bacteroidetes	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
WLSH3_k127_5556271_2	1183377.Py04_1591	3.941e-06	55.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,2448C@183968|Thermococci	183968|Thermococci	L	UPF0292 protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
WLSH3_k127_5556271_0	1347087.CBYO010000007_gene995	1.474e-98	333.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HCC1@91061|Bacilli	91061|Bacilli	E	Dehydrogenase	gutB	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_5556271_3	335283.Neut_0417	0.0004093	49.0	COG1765@1|root,COG1765@2|Bacteria,1QXHR@1224|Proteobacteria,2WH4K@28216|Betaproteobacteria,373XY@32003|Nitrosomonadales	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
WLSH3_k127_5556271_1	1041930.Mtc_1360	1.528e-11	68.0	COG0177@1|root,COG1656@1|root,arCOG00459@2157|Archaea,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,2N9WI@224756|Methanomicrobia	224756|Methanomicrobia	L	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
WLSH3_k127_5590870_0	247490.KSU1_C1165	8.141e-51	187.0	COG0388@1|root,COG0388@2|Bacteria,2IXKW@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
WLSH3_k127_5590870_2	565033.GACE_2045	6.62e-25	108.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ89@28890|Euryarchaeota,247AV@183980|Archaeoglobi	183980|Archaeoglobi	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
WLSH3_k127_5590870_4	593750.Metfor_1649	1.146e-10	70.0	COG0457@1|root,arCOG03042@1|root,arCOG03032@2157|Archaea,arCOG03038@2157|Archaea,arCOG03042@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAN4@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
WLSH3_k127_5590870_3	195522.BD01_0724	5.716e-17	93.0	COG0515@1|root,COG4945@1|root,arCOG01310@2157|Archaea,arCOG03682@2157|Archaea,2XTG6@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	2.7.1.37,2.7.11.1	ko:K00870,ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase
WLSH3_k127_5590870_1	456442.Mboo_0495	1.227e-32	145.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
WLSH3_k127_5619425_0	768710.DesyoDRAFT_1477	7.965e-39	155.0	COG0500@1|root,COG2226@2|Bacteria,1UF5I@1239|Firmicutes,24GYC@186801|Clostridia,265WA@186807|Peptococcaceae	186801|Clostridia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_5619425_1	395495.Lcho_3739	2.601e-28	127.0	COG0689@1|root,COG5276@1|root,COG0689@2|Bacteria,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria	1224|Proteobacteria	N	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,He_PIG,LVIVD
WLSH3_k127_5663143_3	1499683.CCFF01000017_gene1878	0.0002232	52.0	COG0477@1|root,COG2814@2|Bacteria,1VB8Y@1239|Firmicutes,24KIW@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
WLSH3_k127_5663143_0	326424.FRAAL4588	6.992e-133	433.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4ES5V@85013|Frankiales	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
WLSH3_k127_5663143_1	269799.Gmet_2663	4.202e-42	171.0	COG0457@1|root,COG4627@1|root,COG0457@2|Bacteria,COG4627@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
WLSH3_k127_5663143_2	771875.Ferpe_2025	1.11e-26	110.0	COG1884@1|root,COG1884@2|Bacteria,2GBZM@200918|Thermotogae	200918|Thermotogae	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
WLSH3_k127_5671610_0	1232437.KL661965_gene3264	5.375e-49	181.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria,42WP6@68525|delta/epsilon subdivisions,2WSCA@28221|Deltaproteobacteria,2MNZT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Ethanolamine utilisation protein EutA	-	-	-	-	-	-	-	-	-	-	-	-	EutA
WLSH3_k127_5671610_1	748727.CLJU_c11760	6.342e-15	85.0	COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia,36JBF@31979|Clostridiaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
WLSH3_k127_5689377_1	926567.TheveDRAFT_1741	8.253e-49	186.0	COG1834@1|root,COG1834@2|Bacteria,3TBZG@508458|Synergistetes	508458|Synergistetes	E	PFAM amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
WLSH3_k127_5689377_0	1232437.KL661965_gene3264	4.776e-112	378.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria,42WP6@68525|delta/epsilon subdivisions,2WSCA@28221|Deltaproteobacteria,2MNZT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Ethanolamine utilisation protein EutA	-	-	-	-	-	-	-	-	-	-	-	-	EutA
WLSH3_k127_572314_0	765177.Desmu_0156	1.022e-25	110.0	COG0402@1|root,arCOG00695@2157|Archaea,2XPV1@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
WLSH3_k127_5735438_2	382464.ABSI01000007_gene4185	3.534e-17	91.0	COG4076@1|root,COG4076@2|Bacteria,46W2E@74201|Verrucomicrobia	2|Bacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.319	ko:K11434	ko04068,ko04922,map04068,map04922	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko00001,ko01000,ko03036	-	-	-	Methyltransf_25,Methyltransf_31,PRMT5_C,PrmA
WLSH3_k127_5735438_1	1042877.GQS_02055	2.444e-56	207.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,24312@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
WLSH3_k127_5735438_0	694429.Pyrfu_1703	8.517e-82	281.0	COG0005@1|root,arCOG01327@2157|Archaea,2XPU0@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
WLSH3_k127_5764311_0	644281.MFS40622_0309	6.987e-89	314.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,23Q0A@183939|Methanococci	183939|Methanococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
WLSH3_k127_5764311_1	383372.Rcas_0358	9.443e-29	126.0	COG0558@1|root,COG0558@2|Bacteria,2GAQW@200795|Chloroflexi,3773G@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
WLSH3_k127_5805585_0	644966.Tmar_1118	5.999e-28	128.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,2481K@186801|Clostridia	186801|Clostridia	C	FAD dependent oxidoreductase	fixC	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thi4
WLSH3_k127_5812195_0	269797.Mbar_A0543	4.349e-237	752.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,2N99D@224756|Methanomicrobia	224756|Methanomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
WLSH3_k127_5812195_1	751944.HALDL1_12380	8.574e-47	181.0	COG0596@1|root,arCOG01648@2157|Archaea,2XV6R@28890|Euryarchaeota,23T21@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
WLSH3_k127_5820482_0	1220534.B655_1070	1.287e-153	503.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	sdhA	-	1.3.4.1	ko:K18209	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_5820482_1	386456.JQKN01000001_gene1892	7.13e-97	331.0	COG0479@1|root,arCOG00963@2157|Archaea,2Y85K@28890|Euryarchaeota,23PZE@183925|Methanobacteria	183925|Methanobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
WLSH3_k127_5833339_3	234267.Acid_2435	6.558e-06	49.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_5833339_1	1324957.K933_13706	9.193e-63	224.0	COG1712@1|root,arCOG00254@2157|Archaea,2XUNA@28890|Euryarchaeota	28890|Euryarchaeota	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
WLSH3_k127_5833339_2	1449126.JQKL01000011_gene3573	7.041e-21	98.0	COG0673@1|root,COG0673@2|Bacteria,1VDIU@1239|Firmicutes,24MT3@186801|Clostridia	186801|Clostridia	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5833339_0	1200792.AKYF01000021_gene5396	6.727e-64	233.0	COG4927@1|root,COG4927@2|Bacteria,1UEAE@1239|Firmicutes,4HCWI@91061|Bacilli	91061|Bacilli	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
WLSH3_k127_5844776_0	304371.MCP_0104	3.903e-18	94.0	COG0467@1|root,COG2018@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,arCOG02603@2157|Archaea,2XXH5@28890|Euryarchaeota,2NB6W@224756|Methanomicrobia	224756|Methanomicrobia	T	ADP-ribosylation factor family	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
WLSH3_k127_5844776_1	572546.Arcpr_1046	1.151e-10	72.0	COG0457@1|root,arCOG03045@2157|Archaea,2Y4YR@28890|Euryarchaeota	28890|Euryarchaeota	S	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_10
WLSH3_k127_5844776_2	937777.Deipe_0806	0.0001386	55.0	COG1404@1|root,COG1404@2|Bacteria,1WMBP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
WLSH3_k127_5857388_2	1173025.GEI7407_2627	8.515e-15	75.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	-	-	-	-	-	-	-	-	-	-	NERD,zf-C4_Topoisom
WLSH3_k127_5857388_0	488538.SAR116_1362	4.645e-102	336.0	COG0537@1|root,COG1403@1|root,COG0537@2|Bacteria,COG1403@2|Bacteria,1N3EA@1224|Proteobacteria,2UN7N@28211|Alphaproteobacteria,4BSEW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	FGV	Scavenger mRNA decapping enzyme C-term binding	-	-	-	-	-	-	-	-	-	-	-	-	HIT,HNH
WLSH3_k127_5857388_1	488538.SAR116_1362	3.706e-24	105.0	COG0537@1|root,COG1403@1|root,COG0537@2|Bacteria,COG1403@2|Bacteria,1N3EA@1224|Proteobacteria,2UN7N@28211|Alphaproteobacteria,4BSEW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	FGV	Scavenger mRNA decapping enzyme C-term binding	-	-	-	-	-	-	-	-	-	-	-	-	HIT,HNH
WLSH3_k127_5883519_0	1340434.AXVA01000016_gene733	6.594e-42	166.0	COG1131@1|root,COG1131@2|Bacteria,1TQEV@1239|Firmicutes,4HBHF@91061|Bacilli,1ZBR2@1386|Bacillus	91061|Bacilli	V	ABC transporter, ATP-binding protein	yxlF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_5883519_2	47839.CCAU010000011_gene5721	4.36e-06	52.0	COG0507@1|root,COG0507@2|Bacteria	2|Bacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K01144,ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2,Viral_helicase1
WLSH3_k127_5883519_4	59374.Fisuc_1069	6.611e-05	54.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
WLSH3_k127_5883519_1	673860.AciM339_0522	1.288e-12	79.0	arCOG02499@1|root,arCOG02550@1|root,arCOG02499@2157|Archaea,arCOG02550@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD,Pkinase
WLSH3_k127_5883519_3	269797.Mbar_A2754	5.686e-06	58.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
WLSH3_k127_5888295_6	1280390.CBQR020000097_gene2196	6.894e-06	55.0	2E6H4@1|root,3314B@2|Bacteria,1VW5U@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5888295_3	795797.C497_07209	2.607e-32	135.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,23SMM@183963|Halobacteria	28890|Euryarchaeota	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
WLSH3_k127_5888295_4	339860.Msp_0527	1.61e-08	61.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y84Y@28890|Euryarchaeota,23P35@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
WLSH3_k127_5888295_5	1173029.JH980292_gene2288	6.775e-06	58.0	COG0457@1|root,COG0457@2|Bacteria,1GD9N@1117|Cyanobacteria,1HH3D@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
WLSH3_k127_5888295_1	1365176.N186_00370	6.708e-68	244.0	COG0451@1|root,arCOG01369@2157|Archaea,2XRSX@28889|Crenarchaeota	28889|Crenarchaeota	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
WLSH3_k127_5888295_0	643648.Slip_2154	2.022e-133	443.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,42KWJ@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
WLSH3_k127_5888295_2	1121422.AUMW01000045_gene1210	1.733e-36	143.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260YA@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
WLSH3_k127_5891914_1	1365176.N186_01910	4.021e-53	191.0	COG1245@1|root,arCOG00187@2157|Archaea,2XPQF@28889|Crenarchaeota	28889|Crenarchaeota	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,Fer4_6,RLI
WLSH3_k127_5891914_2	444157.Tneu_1740	8.546e-25	109.0	COG0727@1|root,arCOG02579@2157|Archaea,2XR8B@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WLSH3_k127_5891914_0	196162.Noca_1465	1.07e-56	208.0	COG0613@1|root,COG0613@2|Bacteria,2GNAP@201174|Actinobacteria,4DP8Q@85009|Propionibacteriales	201174|Actinobacteria	S	DNA polymerase alpha chain like domain	PPA1328	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
WLSH3_k127_5900045_2	1295642.H839_15908	6.632e-05	53.0	COG4722@1|root,COG4722@2|Bacteria,1UZBC@1239|Firmicutes,4HQQB@91061|Bacilli,1WH3C@129337|Geobacillus	91061|Bacilli	S	Phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Sipho_tail
WLSH3_k127_5900045_1	671065.MetMK1DRAFT_00030780	2.437e-14	79.0	arCOG05900@1|root,arCOG05900@2157|Archaea,2XRDZ@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
WLSH3_k127_5900045_0	1459636.NTE_02560	6.034e-22	100.0	COG4741@1|root,arCOG05252@2157|Archaea	2157|Archaea	F	related to archaeal Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
WLSH3_k127_5907694_0	195522.BD01_0542	3.707e-82	282.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
WLSH3_k127_5907694_3	573413.Spirs_1723	3.328e-42	167.0	COG1829@1|root,COG1829@2|Bacteria	2|Bacteria	S	kinase activity	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
WLSH3_k127_5907694_1	572478.Vdis_0593	1.222e-77	268.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
WLSH3_k127_5907694_2	401526.TcarDRAFT_1939	1.977e-56	209.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,4H595@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
WLSH3_k127_5907694_4	224719.Abm4_0336	1.439e-33	136.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,23PIG@183925|Methanobacteria	183925|Methanobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_5922772_1	192952.MM_0870	1.24e-45	171.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
WLSH3_k127_5922772_0	877455.Metbo_1378	1.165e-139	452.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
WLSH3_k127_5935717_0	1459636.NTE_03124	3.28e-34	145.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
WLSH3_k127_5935717_2	80637.XP_007763443.1	1.896e-07	59.0	COG4352@1|root,KOG3295@2759|Eukaryota,39QV9@33154|Opisthokonta,3P222@4751|Fungi,3V0JJ@5204|Basidiomycota,226NU@155619|Agaricomycetes	4751|Fungi	J	ribosomal protein	rpl13	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006914,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0015934,GO:0016236,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0061919,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e
WLSH3_k127_5935717_1	196162.Noca_2683	5.43e-26	113.0	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4DPZN@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_5979370_1	186497.PF1461	9.439e-106	353.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2439K@183968|Thermococci	183968|Thermococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
WLSH3_k127_5979370_0	368408.Tpen_0360	7.741e-199	638.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
WLSH3_k127_5992058_2	525897.Dbac_1221	1.086e-44	173.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
WLSH3_k127_5992058_3	1463909.KL585962_gene4754	2.637e-13	77.0	2BA9I@1|root,323PQ@2|Bacteria,2H8E5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5992058_4	351160.RRC120	2.39e-09	62.0	COG0095@1|root,arCOG03837@2157|Archaea	2157|Archaea	H	Lipoate-protein ligase a	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	Lip_prot_lig_C
WLSH3_k127_5992058_0	744872.Spica_1727	8.869e-80	273.0	COG0095@1|root,COG0095@2|Bacteria,2J7CV@203691|Spirochaetes	203691|Spirochaetes	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
WLSH3_k127_5992058_1	592015.HMPREF1705_00650	2.455e-79	275.0	COG2516@1|root,COG2516@2|Bacteria,3TB3Y@508458|Synergistetes	508458|Synergistetes	S	Radical SAM domain protein	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
WLSH3_k127_6019065_0	304371.MCP_1288	2.241e-40	167.0	arCOG06516@1|root,arCOG06712@1|root,arCOG06516@2157|Archaea,arCOG06712@2157|Archaea,2XYJJ@28890|Euryarchaeota	28890|Euryarchaeota	T	Pas domain s-box	-	-	-	-	-	-	-	-	-	-	-	-	DUF835,HAMP,HATPase_c,PAS,PAS_9
WLSH3_k127_6036935_0	926569.ANT_17220	2.013e-47	174.0	COG2414@1|root,COG2414@2|Bacteria,2G80A@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_6036935_1	1123288.SOV_1c12530	1.922e-07	56.0	COG1977@1|root,COG1977@2|Bacteria,1VIUV@1239|Firmicutes,4H5UH@909932|Negativicutes	909932|Negativicutes	H	Mut7-C ubiquitin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
WLSH3_k127_6036935_2	1249975.JQLP01000003_gene76	4.851e-05	54.0	COG1361@1|root,COG3266@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1HZAG@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
WLSH3_k127_6077529_0	1237149.C900_00319	0.0002024	55.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,4NU1P@976|Bacteroidetes,47XBG@768503|Cytophagia	976|Bacteroidetes	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
WLSH3_k127_6096948_2	1054213.HMPREF9946_01767	4.137e-23	106.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQSU@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Hydantoinase/oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
WLSH3_k127_6096948_0	1121451.DESAM_21250	1.589e-160	521.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,43CGH@68525|delta/epsilon subdivisions,2WJ3J@28221|Deltaproteobacteria,2M83K@213115|Desulfovibrionales	28221|Deltaproteobacteria	EQ	PFAM Hydantoinase B oxoprolinase	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
WLSH3_k127_6096948_1	272844.PAB0323	1.729e-138	459.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
WLSH3_k127_6102422_0	374847.Kcr_1341	1.07e-53	202.0	COG1503@1|root,arCOG01742@2157|Archaea	2157|Archaea	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
WLSH3_k127_6102422_1	374847.Kcr_1603	2.071e-21	103.0	COG0016@1|root,arCOG00410@2157|Archaea	2157|Archaea	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
WLSH3_k127_6122852_0	572479.Hprae_0499	1.646e-72	261.0	COG2407@1|root,COG2407@2|Bacteria,1TPEK@1239|Firmicutes,24BY2@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6154856_0	1220534.B655_1154	1.264e-49	183.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
WLSH3_k127_6159924_2	1227454.C446_00050	4.314e-08	55.0	COG0601@1|root,arCOG00751@2157|Archaea,2XU87@28890|Euryarchaeota,23S7B@183963|Halobacteria	183963|Halobacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_6159924_0	351160.LRC379	7.084e-82	293.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,2N9GM@224756|Methanomicrobia	224756|Methanomicrobia	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_6159924_1	415426.Hbut_0606	3.694e-31	126.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPYD@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_6180491_0	4565.Traes_2DS_0BDFD6AEE.1	5.33e-10	66.0	KOG3330@1|root,KOG3330@2759|Eukaryota,37NAF@33090|Viridiplantae,3G7XM@35493|Streptophyta,3KRZY@4447|Liliopsida,3I3NF@38820|Poales	35493|Streptophyta	U	May play a role in vesicular transport from endoplasmic reticulum to Golgi	-	-	-	ko:K20302	-	-	-	-	ko00000,ko04131	-	-	-	TRAPP
WLSH3_k127_6193025_0	1121381.JNIV01000036_gene3341	1.204e-86	301.0	COG0624@1|root,COG0624@2|Bacteria,1WIRQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_621175_0	368408.Tpen_0478	6.365e-30	136.0	COG1199@1|root,arCOG00770@2157|Archaea,2XPRS@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM DEAD_2 domain protein	-	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0043139,GO:0048037,GO:0051276,GO:0051536,GO:0051539,GO:0051540,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
WLSH3_k127_6237151_1	1336241.JAEB01000015_gene1612	5.141e-16	93.0	COG1800@1|root,COG4305@1|root,COG1800@2|Bacteria,COG4305@2|Bacteria,1UMHD@1239|Firmicutes,25GIA@186801|Clostridia	186801|Clostridia	G	CBD_II	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2
WLSH3_k127_6237151_0	69014.TK2264	1.328e-74	277.0	COG1800@1|root,arCOG07561@1|root,arCOG02164@2157|Archaea,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota,2435K@183968|Thermococci	183968|Thermococci	K	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
WLSH3_k127_6237151_2	5911.EAR89871	2.667e-14	85.0	COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota	2759|Eukaryota	O	protein N-acetylglucosaminyltransferase activity	-	-	2.4.1.255	ko:K09667	ko00514,ko04931,map00514,map04931	-	R09304,R09676	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03036	-	GT41	-	TPR_8
WLSH3_k127_6252469_4	368408.Tpen_0713	5.331e-37	143.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
WLSH3_k127_6252469_2	374847.Kcr_1381	7.083e-70	246.0	COG1122@1|root,arCOG00188@2157|Archaea	2157|Archaea	P	PFAM ABC transporter related	phnG	-	2.7.8.37	ko:K03529,ko:K06166,ko:K16786,ko:K16787	ko00440,ko02010,map00440,map02010	M00582	R10185	RC00005,RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko03036	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,PhnG,SMC_N,SMC_hinge
WLSH3_k127_6252469_3	415426.Hbut_0577	3.194e-40	162.0	COG0618@1|root,arCOG01565@2157|Archaea,2XQUB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
WLSH3_k127_6252469_9	1042877.GQS_02940	2.144e-05	51.0	arCOG05854@1|root,arCOG05854@2157|Archaea,2Y45W@28890|Euryarchaeota,244I2@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF3194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3194
WLSH3_k127_6252469_6	195522.BD01_0249	4.839e-15	80.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,244D1@183968|Thermococci	183968|Thermococci	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044464,GO:0071840	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
WLSH3_k127_6252469_8	868131.MSWAN_0466	1.224e-08	61.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y1HA@28890|Euryarchaeota,23P8R@183925|Methanobacteria	183925|Methanobacteria	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
WLSH3_k127_6252469_7	374847.Kcr_1367	2.72e-13	78.0	COG2136@1|root,arCOG03247@2157|Archaea	2157|Archaea	AJ	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
WLSH3_k127_6252469_5	342949.PNA2_0520	3.018e-26	112.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
WLSH3_k127_6252469_1	593117.TGAM_2035	2.974e-70	247.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
WLSH3_k127_6252469_0	246969.TAM4_251	1.503e-72	252.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
WLSH3_k127_6300499_4	439481.Aboo_0333	3.62e-06	54.0	COG0803@1|root,arCOG01005@2157|Archaea,2XVB3@28890|Euryarchaeota,3F303@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	PFAM periplasmic solute binding protein	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
WLSH3_k127_6300499_3	980584.AFPB01000152_gene413	4.078e-09	67.0	COG0679@1|root,COG0679@2|Bacteria,4NIQF@976|Bacteroidetes,1I08Z@117743|Flavobacteriia	976|Bacteroidetes	S	transporter	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
WLSH3_k127_6300499_5	1121422.AUMW01000018_gene1909	7.977e-05	49.0	COG3255@1|root,COG3255@2|Bacteria,1VFEY@1239|Firmicutes,24QXQ@186801|Clostridia,263BY@186807|Peptococcaceae	186801|Clostridia	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_6300499_0	1163730.FFONT_0226	1.119e-142	472.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_6300499_1	1163730.FFONT_0548	4.333e-50	189.0	COG0235@1|root,arCOG04226@2157|Archaea,2XQGF@28889|Crenarchaeota	28889|Crenarchaeota	G	Class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
WLSH3_k127_6300499_2	1499967.BAYZ01000148_gene1738	1.796e-44	175.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	lsrK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009372,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0042710,GO:0044010,GO:0044237,GO:0044764,GO:0051704,GO:0071518	2.7.1.189	ko:K11216	ko02024,map02024	-	R11183	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_6315403_1	404380.Gbem_3219	5.408e-35	149.0	COG2234@1|root,COG2234@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions,2X60E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
WLSH3_k127_6315403_0	394221.Mmar10_1145	1.811e-56	203.0	29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,2UAW7@28211|Alphaproteobacteria,43XXB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
WLSH3_k127_6315403_3	1283300.ATXB01000002_gene2631	1.733e-26	117.0	COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6315403_2	500635.MITSMUL_04598	5.306e-27	120.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4H3ZP@909932|Negativicutes	909932|Negativicutes	S	Serine aminopeptidase, S33	est	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
WLSH3_k127_6315403_4	368408.Tpen_1831	3.939e-13	72.0	COG2211@1|root,arCOG00146@2157|Archaea,2XSCD@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
WLSH3_k127_6327064_1	144197.XP_008282922.1	0.0009014	46.0	KOG0443@1|root,KOG0443@2759|Eukaryota,38BDF@33154|Opisthokonta,3B9RZ@33208|Metazoa,3CXQR@33213|Bilateria,4865S@7711|Chordata,48Y44@7742|Vertebrata,4A1SI@7898|Actinopterygii	33208|Metazoa	Z	Advillin	AVIL	GO:0002009,GO:0002165,GO:0003674,GO:0003779,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006996,GO:0007010,GO:0007015,GO:0007275,GO:0007399,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008092,GO:0008150,GO:0008544,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009913,GO:0009987,GO:0010720,GO:0010975,GO:0010976,GO:0015629,GO:0016043,GO:0022008,GO:0022607,GO:0030029,GO:0030030,GO:0030031,GO:0030036,GO:0030154,GO:0030182,GO:0030855,GO:0031344,GO:0031346,GO:0032501,GO:0032502,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0035315,GO:0035316,GO:0035317,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044424,GO:0044464,GO:0044782,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046872,GO:0048513,GO:0048518,GO:0048522,GO:0048563,GO:0048569,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051128,GO:0051130,GO:0051239,GO:0051240,GO:0051960,GO:0051962,GO:0060271,GO:0060284,GO:0060429,GO:0060562,GO:0065007,GO:0070925,GO:0071840,GO:0097435,GO:0097458,GO:0120025,GO:0120031,GO:0120035,GO:0120036,GO:2000026	-	ko:K05761,ko:K08017	-	-	-	-	ko00000,ko04812	-	-	-	Gelsolin,VHP
WLSH3_k127_6352379_1	269797.Mbar_A1191	0.0006651	43.0	arCOG04467@1|root,arCOG04467@2157|Archaea,2Y250@28890|Euryarchaeota	28890|Euryarchaeota	H	Mo-molybdopterin cofactor metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6352379_0	338963.Pcar_2514	1.436e-31	128.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,43SV4@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_6380156_0	399550.Smar_1111	3.482e-91	314.0	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
WLSH3_k127_6380156_2	110365.A0A023B838	4.227e-39	157.0	COG1100@1|root,KOG0098@2759|Eukaryota,3Y9NR@5794|Apicomplexa	5794|Apicomplexa	U	Rab2, GTPase	-	GO:0000139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0008150,GO:0012505,GO:0016020,GO:0017157,GO:0031090,GO:0031984,GO:0032879,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045921,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0060627,GO:0065007,GO:0098588,GO:0098791,GO:1903530,GO:1903532	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_6380156_1	439481.Aboo_1538	3.994e-77	269.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,3F2G6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmm4	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WLSH3_k127_6380156_3	945713.IALB_1257	2.424e-07	55.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
WLSH3_k127_6385504_2	479434.Sthe_2461	3.571e-25	111.0	COG0407@1|root,COG0407@2|Bacteria,2G6BE@200795|Chloroflexi,27XYH@189775|Thermomicrobia	189775|Thermomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
WLSH3_k127_6385504_1	1196029.ALIM01000014_gene2645	4.844e-67	243.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,4HBTF@91061|Bacilli,1ZC2K@1386|Bacillus	91061|Bacilli	BQ	histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	iYO844.BSU29710	Hist_deacetyl
WLSH3_k127_6385504_0	572546.Arcpr_0001	4.867e-84	286.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,245XC@183980|Archaeoglobi	183980|Archaeoglobi	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
WLSH3_k127_6395555_0	96561.Dole_2160	3.599e-143	469.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42PRI@68525|delta/epsilon subdivisions,2X5GA@28221|Deltaproteobacteria,2MHVA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
WLSH3_k127_6395555_1	1101188.KI912155_gene3039	1.173e-31	138.0	COG0673@1|root,COG0673@2|Bacteria,2GM7J@201174|Actinobacteria	201174|Actinobacteria	K	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
WLSH3_k127_6408040_4	523845.AQXV01000054_gene1636	2.414e-14	75.0	COG1588@1|root,arCOG00784@2157|Archaea,2XYYU@28890|Euryarchaeota,23R6Y@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
WLSH3_k127_6408040_1	273057.SSO0709	3.541e-32	128.0	COG0186@1|root,arCOG04096@2157|Archaea,2XQZ6@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
WLSH3_k127_6408040_0	673860.AciM339_1108	1.507e-39	151.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,3F2NF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
WLSH3_k127_6408040_3	693661.Arcve_0974	7.286e-25	109.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2474C@183980|Archaeoglobi	183980|Archaeoglobi	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
WLSH3_k127_6408040_2	523850.TON_0078	6.394e-25	106.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,242QU@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
WLSH3_k127_641175_0	56780.SYN_01185	6.704e-42	158.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2MQXP@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	Nitro_FeMo-Co,ParA
WLSH3_k127_641175_1	269799.Gmet_0749	1.683e-10	75.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8
WLSH3_k127_6417895_2	1089548.KI783301_gene959	2.603e-27	118.0	COG1670@1|root,COG1670@2|Bacteria,1V3W1@1239|Firmicutes,4HH6A@91061|Bacilli,3WETK@539002|Bacillales incertae sedis	91061|Bacilli	J	Acetyltransferase (GNAT) domain	speG	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
WLSH3_k127_6417895_0	324057.Pjdr2_1891	3.691e-195	619.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HVE0@91061|Bacilli,271P8@186822|Paenibacillaceae	91061|Bacilli	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_6417895_1	1235798.C817_03675	3.313e-29	121.0	COG0235@1|root,COG0235@2|Bacteria,1V5H8@1239|Firmicutes,24I46@186801|Clostridia,27WW9@189330|Dorea	186801|Clostridia	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
WLSH3_k127_6462873_2	1280698.AUJS01000068_gene702	6.359e-14	76.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,27VYW@189330|Dorea	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_6462873_1	398512.JQKC01000015_gene4671	9.122e-36	147.0	COG1409@1|root,COG1409@2|Bacteria,1UA0Q@1239|Firmicutes,24VZZ@186801|Clostridia	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
WLSH3_k127_6462873_3	523850.TON_0142	3.288e-08	61.0	arCOG06454@1|root,arCOG06454@2157|Archaea,2Y0DQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	RNase_Zc3h12a
WLSH3_k127_6462873_0	754027.HMPREF9554_01184	1.544e-49	179.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WLSH3_k127_6463398_1	1056495.Calag_0282	4.91e-15	79.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	HTH_45
WLSH3_k127_6463398_0	1459636.NTE_00443	4.907e-99	344.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
WLSH3_k127_6501040_0	926569.ANT_11560	3.536e-16	92.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
WLSH3_k127_6501040_1	1385510.N781_10065	5.135e-13	79.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,4H9Q7@91061|Bacilli,2Y8KP@289201|Pontibacillus	91061|Bacilli	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
WLSH3_k127_6520390_2	926569.ANT_11560	6.922e-11	68.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
WLSH3_k127_6520390_1	1511.CLOST_2025	4.044e-26	122.0	COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,25E6H@186801|Clostridia	186801|Clostridia	S	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WLSH3_k127_6520390_0	693661.Arcve_1203	2.692e-164	526.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
WLSH3_k127_6530738_2	933262.AXAM01000133_gene2349	6.719e-16	79.0	COG2445@1|root,COG2445@2|Bacteria,1Q09N@1224|Proteobacteria,42XU8@68525|delta/epsilon subdivisions,2WTB7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
WLSH3_k127_6530738_0	573063.Metin_0604	3.067e-125	414.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23QNJ@183939|Methanococci	183939|Methanococci	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
WLSH3_k127_6530738_1	243232.MJ_1612	5.208e-94	318.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,23PZZ@183939|Methanococci	183939|Methanococci	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
WLSH3_k127_6540434_0	1121468.AUBR01000001_gene538	2.939e-47	179.0	COG1042@1|root,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	2|Bacteria	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K09181	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
WLSH3_k127_6540434_1	1121382.JQKG01000019_gene1233	1.774e-21	105.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	ATP-cone
WLSH3_k127_6577449_2	1220534.B655_0736	2.022e-13	75.0	COG1417@1|root,arCOG04850@2157|Archaea	2157|Archaea	S	to GB L77117 SP Q58031 PID 1591324 percent identity	-	-	-	-	-	-	-	-	-	-	-	-	DUF22
WLSH3_k127_6577449_5	419665.Maeo_0965	6.298e-06	53.0	arCOG05131@1|root,arCOG05131@2157|Archaea	2157|Archaea	S	DsrH like protein	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
WLSH3_k127_6577449_3	319225.Plut_0041	4.32e-12	70.0	COG2923@1|root,COG2923@2|Bacteria,1FF55@1090|Chlorobi	1090|Chlorobi	P	PFAM DsrE family protein	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
WLSH3_k127_6577449_1	264732.Moth_0433	1.009e-17	87.0	COG1553@1|root,COG1553@2|Bacteria,1VG50@1239|Firmicutes,24R7R@186801|Clostridia,42H7U@68295|Thermoanaerobacterales	186801|Clostridia	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
WLSH3_k127_6577449_4	121225.PHUM077890-PA	2.054e-09	70.0	COG4886@1|root,KOG0619@2759|Eukaryota,39WR7@33154|Opisthokonta,3BGRS@33208|Metazoa,3D0NC@33213|Bilateria,41UBX@6656|Arthropoda,3SKE4@50557|Insecta,3E97V@33342|Paraneoptera	33208|Metazoa	S	Leucine Rich Repeat	-	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0007275,GO:0007423,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0031012,GO:0032501,GO:0032502,GO:0040011,GO:0044085,GO:0044421,GO:0044424,GO:0044464,GO:0044782,GO:0048513,GO:0048731,GO:0048856,GO:0060271,GO:0070925,GO:0071840,GO:0120031,GO:0120036	-	-	-	-	-	-	-	-	-	-	LRR_1,LRR_8
WLSH3_k127_6577449_0	880073.Calab_1228	6.504e-50	184.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
WLSH3_k127_6600827_0	565033.GACE_2271	3.255e-09	70.0	arCOG07351@1|root,arCOG07813@1|root,arCOG07351@2157|Archaea,arCOG07813@2157|Archaea,2Y2IH@28890|Euryarchaeota,2477D@183980|Archaeoglobi	183980|Archaeoglobi	S	LamG domain protein jellyroll fold domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6603342_0	1501230.ET33_32420	4.383e-45	175.0	COG2159@1|root,COG2159@2|Bacteria,1TT5D@1239|Firmicutes,4HAHP@91061|Bacilli,26V85@186822|Paenibacillaceae	91061|Bacilli	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
WLSH3_k127_6603342_1	868131.MSWAN_0059	2.637e-13	78.0	COG0671@1|root,arCOG07501@2157|Archaea,2XYXG@28890|Euryarchaeota,23PN8@183925|Methanobacteria	183925|Methanobacteria	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6611088_2	1183377.Py04_1108	5.631e-15	78.0	arCOG04849@1|root,arCOG04849@2157|Archaea,2Y3NE@28890|Euryarchaeota,244DD@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6611088_1	1345697.M493_03760	1.45e-43	165.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,4HH5X@91061|Bacilli,1WFQD@129337|Geobacillus	91061|Bacilli	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
WLSH3_k127_6611088_0	529709.PYCH_06120	1.498e-95	326.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,243SU@183968|Thermococci	183968|Thermococci	E	Catalyzes the decarboxylation of L-aspartate to produce beta-alanine	mfnA	GO:0003674,GO:0003824,GO:0004068,GO:0004351,GO:0005488,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019842,GO:0030170,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070279,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
WLSH3_k127_6611088_3	1125699.HMPREF9194_02121	1.077e-05	50.0	COG1916@1|root,COG1916@2|Bacteria,2J5K2@203691|Spirochaetes	203691|Spirochaetes	S	Pheromone shutdown protein	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
WLSH3_k127_6616601_0	1121405.dsmv_2105	2.36e-138	456.0	COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
WLSH3_k127_6704189_4	1487923.DP73_16610	4.169e-08	56.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24ZPQ@186801|Clostridia	186801|Clostridia	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
WLSH3_k127_6704189_1	293826.Amet_2893	8.903e-17	94.0	28SRE@1|root,2ZF1B@2|Bacteria,1W33E@1239|Firmicutes,24W3Z@186801|Clostridia,36PKN@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CbiX,Ferrochelatase
WLSH3_k127_6704189_2	635013.TherJR_1581	4.53e-11	72.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,261ZE@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
WLSH3_k127_6704189_0	1173026.Glo7428_0224	1.225e-93	336.0	COG0344@1|root,COG0574@1|root,COG3848@1|root,COG0344@2|Bacteria,COG0574@2|Bacteria,COG3848@2|Bacteria,1G2NJ@1117|Cyanobacteria	1117|Cyanobacteria	GT	Pyruvate phosphate dikinase, PEP pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	G3P_acyltransf,PEP-utilizers,PPDK_N
WLSH3_k127_6704189_3	1120999.JONM01000016_gene208	1.279e-09	62.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VHHU@28216|Betaproteobacteria,2KQ6Z@206351|Neisseriales	206351|Neisseriales	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
WLSH3_k127_6706256_3	351160.LRC30	1.515e-64	228.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,2N926@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin,tRNA_deacylase
WLSH3_k127_6706256_16	591019.Shell_1385	0.000958	45.0	COG2443@1|root,arCOG02204@2157|Archaea	2157|Archaea	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
WLSH3_k127_6706256_9	1042877.GQS_03740	1.142e-27	121.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2441S@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
WLSH3_k127_6706256_7	272844.PAB2353	2.278e-46	174.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,243FN@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
WLSH3_k127_6706256_6	1041930.Mtc_1421	5.035e-49	182.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,2N9HV@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
WLSH3_k127_6706256_5	797209.ZOD2009_07774	3.038e-58	216.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23T1A@183963|Halobacteria	183963|Halobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
WLSH3_k127_6706256_10	342949.PNA2_0816	1.103e-26	112.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,244BE@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
WLSH3_k127_6706256_4	1121468.AUBR01000054_gene1448	1.562e-60	218.0	COG0123@1|root,COG0123@2|Bacteria,1V066@1239|Firmicutes,2483W@186801|Clostridia	186801|Clostridia	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
WLSH3_k127_6706256_1	351160.RCIX396	7.994e-148	486.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_6706256_11	696369.KI912183_gene2680	3.441e-23	111.0	COG0611@1|root,COG0611@2|Bacteria,1V0SM@1239|Firmicutes,24J04@186801|Clostridia,262KV@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WLSH3_k127_6706256_14	641107.CDLVIII_3875	2.297e-12	71.0	arCOG09714@1|root,33H0I@2|Bacteria,1VG6M@1239|Firmicutes,24PAY@186801|Clostridia,36VCR@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6706256_12	59538.XP_005970834.1	8.375e-23	110.0	COG0673@1|root,KOG2741@2759|Eukaryota,38DJH@33154|Opisthokonta,3BNHQ@33208|Metazoa,3D3ZX@33213|Bilateria,48DFI@7711|Chordata,495V1@7742|Vertebrata,3JG4J@40674|Mammalia	33208|Metazoa	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
WLSH3_k127_6706256_2	391623.TERMP_01501	8.125e-89	309.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,243CJ@183968|Thermococci	183968|Thermococci	J	methylthiotransferase activity	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
WLSH3_k127_6706256_15	867903.ThesuDRAFT_00145	3.929e-08	59.0	COG0476@1|root,COG0607@1|root,COG1977@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,COG1977@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,3WDCG@538999|Clostridiales incertae sedis	186801|Clostridia	H	ThiF family	-	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
WLSH3_k127_6706256_13	526222.Desal_0749	2.273e-14	78.0	2E481@1|root,32Z3Y@2|Bacteria,1R0S7@1224|Proteobacteria,43D0S@68525|delta/epsilon subdivisions,2X88M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6706256_0	186497.PF2000	7.525e-196	623.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
WLSH3_k127_6706256_8	1184251.TCELL_0804	7.182e-46	171.0	COG0403@1|root,arCOG00077@2157|Archaea,2XQ1W@28889|Crenarchaeota	28889|Crenarchaeota	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
WLSH3_k127_6710214_0	246969.TAM4_1357	4.451e-62	220.0	COG2521@1|root,arCOG00054@2157|Archaea,2Y2KZ@28890|Euryarchaeota,243QH@183968|Thermococci	183968|Thermococci	Q	Spermine/spermidine synthase domain	-	-	-	ko:K06983	-	-	-	-	ko00000	-	-	-	Methyltransf_11,Methyltransf_25
WLSH3_k127_6710214_3	760154.Sulba_0848	8.891e-12	76.0	COG3608@1|root,COG3608@2|Bacteria,1RG3Y@1224|Proteobacteria,42R0N@68525|delta/epsilon subdivisions,2YNXP@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
WLSH3_k127_6710214_1	1365176.N186_01240	2.111e-24	108.0	arCOG00299@1|root,arCOG00299@2157|Archaea,2XQKR@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6710214_2	643867.Ftrac_2288	3.008e-20	98.0	COG2020@1|root,COG2020@2|Bacteria,4NTXI@976|Bacteroidetes,47RFP@768503|Cytophagia	976|Bacteroidetes	O	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
WLSH3_k127_6739867_0	235985.BBPN01000020_gene6477	4.56e-48	177.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,2NHRD@228398|Streptacidiphilus	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_6745197_1	868131.MSWAN_1557	2.982e-11	71.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_6745197_2	588932.JHOF01000024_gene89	5.586e-11	67.0	COG0640@1|root,COG0640@2|Bacteria,1QVFX@1224|Proteobacteria,2TWEG@28211|Alphaproteobacteria,2KH4Z@204458|Caulobacterales	204458|Caulobacterales	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
WLSH3_k127_6745197_0	368407.Memar_1073	1.647e-49	186.0	arCOG02449@1|root,arCOG02449@2157|Archaea,2XZ1K@28890|Euryarchaeota,2NAXS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_6745197_3	1322246.BN4_10135	0.000123	48.0	COG1977@1|root,COG1977@2|Bacteria,1NH6M@1224|Proteobacteria,42X05@68525|delta/epsilon subdivisions,2WSK5@28221|Deltaproteobacteria,2MD55@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM ThiamineS	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
WLSH3_k127_6765552_1	439235.Dalk_0051	2.8e-89	300.0	COG1145@1|root,COG1145@2|Bacteria	439235.Dalk_0051|-	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6765552_3	643648.Slip_1979	1.314e-16	82.0	COG2250@1|root,COG2250@2|Bacteria,1U5S6@1239|Firmicutes,259NY@186801|Clostridia,42KY7@68298|Syntrophomonadaceae	186801|Clostridia	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
WLSH3_k127_6765552_2	1041930.Mtc_1182	1.207e-17	86.0	COG1708@1|root,arCOG01195@2157|Archaea	2157|Archaea	S	DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
WLSH3_k127_6765552_4	439481.Aboo_0779	7.12e-13	81.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03607@2157|Archaea	2157|Archaea	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,Big_3_5,NosD,PKD,Peptidase_C1,S_layer_C
WLSH3_k127_6765552_0	186497.PF1631	2.733e-90	313.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y2ZW@28890|Euryarchaeota,245AV@183968|Thermococci	183968|Thermococci	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
WLSH3_k127_6765552_5	232348.ADXL01000083_gene890	6.159e-12	71.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF86,NTP_transf_2
WLSH3_k127_6789777_1	374847.Kcr_1472	1.521e-33	138.0	COG0714@1|root,arCOG00441@2157|Archaea	2157|Archaea	V	ATPase associated with various cellular activities, AAA_5	gvpN	-	-	ko:K03924,ko:K04748	-	-	R00294	RC02794	ko00000,ko01000	3.D.4.10	-	-	AAA_5,CbbQ_C,HHH_5
WLSH3_k127_6789777_0	760568.Desku_2713	1.518e-50	185.0	COG5012@1|root,COG5012@2|Bacteria,1V33W@1239|Firmicutes,24J77@186801|Clostridia,266X4@186807|Peptococcaceae	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
WLSH3_k127_6795980_2	1242864.D187_009330	2.653e-17	94.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6795980_1	1184251.TCELL_0650	5.289e-19	100.0	COG1602@1|root,arCOG04269@2157|Archaea,2XPMN@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Archaeal protein of	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
WLSH3_k127_6795980_0	1365176.N186_06505	1.453e-21	108.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2XSKE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Zinc finger TFIIB-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
WLSH3_k127_6815328_3	1450694.BTS2_4075	8.642e-06	52.0	COG0500@1|root,COG0500@2|Bacteria,1V0PR@1239|Firmicutes,4HB7J@91061|Bacilli,1ZEGC@1386|Bacillus	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_6815328_2	1128912.GMES_2076	7.697e-09	63.0	COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
WLSH3_k127_6815328_1	330214.NIDE3895	8.293e-30	123.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
WLSH3_k127_6815328_0	1131266.ARWQ01000001_gene1090	4.618e-62	224.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
WLSH3_k127_6822406_0	272557.APE_1432	6.222e-142	471.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WLSH3_k127_6822406_4	1449346.JQMO01000003_gene5946	3.162e-25	115.0	COG0500@1|root,COG2226@2|Bacteria,2I24W@201174|Actinobacteria,2M61Q@2063|Kitasatospora	201174|Actinobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_6822406_1	985053.VMUT_2008	9.836e-63	224.0	COG1402@1|root,arCOG04536@2157|Archaea,2XQVG@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
WLSH3_k127_6822406_3	743525.TSC_c09700	7.525e-35	144.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
WLSH3_k127_6822406_2	1128421.JAGA01000002_gene1359	2.929e-53	202.0	COG0520@1|root,COG0520@2|Bacteria,2NP4B@2323|unclassified Bacteria	2|Bacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
WLSH3_k127_6835968_0	690850.Desaf_0428	3.401e-30	138.0	COG3266@1|root,COG3391@1|root,COG4870@1|root,COG3266@2|Bacteria,COG3391@2|Bacteria,COG4870@2|Bacteria,1NC9B@1224|Proteobacteria,42Z35@68525|delta/epsilon subdivisions,2WTVH@28221|Deltaproteobacteria,2MD34@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM Peptidase C1A, papain C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
WLSH3_k127_6842214_1	1122128.AUEE01000002_gene1301	1.979e-20	101.0	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli,4GY6P@90964|Staphylococcaceae	91061|Bacilli	D	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WLSH3_k127_6842214_0	1385935.N836_03485	4.062e-70	243.0	COG1357@1|root,COG1357@2|Bacteria,1GDBA@1117|Cyanobacteria	1117|Cyanobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,TIR_2
WLSH3_k127_6843617_0	909663.KI867149_gene3286	0.0	1106.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,42SZ0@68525|delta/epsilon subdivisions,2WPIR@28221|Deltaproteobacteria,2MQGQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883,Helicase_C,SNF2_N
WLSH3_k127_6844239_1	439481.Aboo_0620	1.33e-08	66.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
WLSH3_k127_6844239_0	304371.MCP_1482	9.846e-178	589.0	COG0574@1|root,arCOG01114@2157|Archaea,2XVSY@28890|Euryarchaeota	28890|Euryarchaeota	G	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
WLSH3_k127_6844239_2	1282876.BAOK01000001_gene2087	3.116e-07	53.0	28M2T@1|root,2ZAH6@2|Bacteria,1R6GW@1224|Proteobacteria,2U25T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6861770_1	391623.TERMP_00850	1.508e-52	193.0	arCOG04883@1|root,arCOG04883@2157|Archaea,2XZSU@28890|Euryarchaeota,243Q7@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6861770_0	593750.Metfor_2146	7.195e-77	268.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,2N963@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
WLSH3_k127_6871181_1	246969.TAM4_2030	9.923e-75	260.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
WLSH3_k127_6871181_4	365044.Pnap_2813	1.337e-14	79.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_6871181_2	523850.TON_0362	2.236e-66	237.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WLSH3_k127_6871181_0	339860.Msp_1360	1.194e-104	350.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_6871181_3	573063.Metin_0629	6.705e-27	113.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23R03@183939|Methanococci	183939|Methanococci	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
WLSH3_k127_6952924_0	429009.Adeg_1700	2.549e-85	291.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
WLSH3_k127_6952924_1	1121423.JONT01000009_gene1434	2.368e-56	211.0	COG0857@1|root,COG0857@2|Bacteria,1UFKM@1239|Firmicutes,25M79@186801|Clostridia,260XJ@186807|Peptococcaceae	186801|Clostridia	C	DRTGG domain protein	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
WLSH3_k127_6952924_2	1232410.KI421415_gene2936	2.604e-09	67.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_6972818_1	272557.APE_1495a	7.741e-11	65.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
WLSH3_k127_6972818_0	509191.AEDB02000073_gene1859	3.871e-27	114.0	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,3WNNC@541000|Ruminococcaceae	186801|Clostridia	O	PPIC-type PPIASE domain	prsA2	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
WLSH3_k127_7014481_3	1206777.B195_10106	5.824e-10	68.0	COG3233@1|root,COG3233@2|Bacteria,1RIED@1224|Proteobacteria	1224|Proteobacteria	S	deacetylase	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
WLSH3_k127_7014481_2	523850.TON_0185	5.495e-13	71.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
WLSH3_k127_7014481_1	1041930.Mtc_0093	5.555e-84	293.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
WLSH3_k127_7014481_0	485913.Krac_10143	3.465e-127	422.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi	200795|Chloroflexi	EQ	Hydantoinaseoxoprolinase domain protein	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
WLSH3_k127_7058310_0	572546.Arcpr_0624	3.55e-33	135.0	COG0642@1|root,arCOG06712@1|root,arCOG06408@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_7058310_1	315749.Bcer98_0953	8.368e-06	57.0	arCOG05209@1|root,31PIN@2|Bacteria,1V5G2@1239|Firmicutes,4HIRV@91061|Bacilli,1ZF0Y@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7058310_2	387631.Asulf_01058	0.0005888	47.0	arCOG04388@1|root,arCOG04388@2157|Archaea,2XXR2@28890|Euryarchaeota,24686@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7085626_0	797209.ZOD2009_17865	4.949e-76	280.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,23SJ7@183963|Halobacteria	183963|Halobacteria	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
WLSH3_k127_7094307_0	1519464.HY22_04205	1.359e-05	48.0	COG2020@1|root,COG2020@2|Bacteria,1FFEK@1090|Chlorobi	1090|Chlorobi	O	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_7120529_0	877455.Metbo_0863	9.77e-98	334.0	COG1035@1|root,COG1941@1|root,arCOG02473@2157|Archaea,arCOG02652@2157|Archaea,2XZ31@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
WLSH3_k127_7120867_2	1122622.ATWJ01000014_gene443	1.016e-42	168.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4FINJ@85021|Intrasporangiaceae	201174|Actinobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
WLSH3_k127_7120867_3	374847.Kcr_0903	2.125e-11	72.0	COG2229@1|root,arCOG00362@2157|Archaea	2157|Archaea	K	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	GTP_EFTU,P-II
WLSH3_k127_7120867_0	1329516.JPST01000003_gene1189	2.255e-74	259.0	COG3970@1|root,COG3970@2|Bacteria,1U819@1239|Firmicutes,4HDEZ@91061|Bacilli	91061|Bacilli	S	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
WLSH3_k127_7120867_1	439481.Aboo_0423	2.01e-62	223.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2Y8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WLSH3_k127_7160273_0	1220534.B655_1327	3.904e-49	182.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXTN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin	-	GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3,Flavodoxin_5
WLSH3_k127_7160273_1	368407.Memar_1136	9.567e-30	135.0	arCOG06516@1|root,arCOG06712@1|root,arCOG06940@1|root,arCOG06516@2157|Archaea,arCOG06712@2157|Archaea,arCOG06940@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
WLSH3_k127_7171124_2	1238425.J07HQW2_01117	6.948e-12	73.0	arCOG03129@1|root,arCOG03129@2157|Archaea,2XTF9@28890|Euryarchaeota,23T0X@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF2797)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2797
WLSH3_k127_7171124_0	1184251.TCELL_0069	1.177e-107	361.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
WLSH3_k127_7171124_1	457570.Nther_2371	2.126e-13	80.0	COG1305@1|root,COG4447@1|root,COG1305@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
WLSH3_k127_7176063_0	399549.Msed_0692	6.476e-51	192.0	COG0189@1|root,arCOG01589@2157|Archaea,2XQGE@28889|Crenarchaeota	28889|Crenarchaeota	H	RimK domain protein ATP-grasp	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
WLSH3_k127_7176063_1	1131266.ARWQ01000006_gene251	3.381e-12	73.0	arCOG03727@1|root,arCOG03727@2157|Archaea,41STD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
WLSH3_k127_7177339_0	1449126.JQKL01000018_gene3311	2.06e-38	151.0	COG4343@1|root,COG4343@2|Bacteria,1TRDE@1239|Firmicutes,24DTN@186801|Clostridia	186801|Clostridia	S	TIGRFAM CRISPR-associated protein	-	-	-	ko:K19085	-	-	-	-	ko00000,ko02048	-	-	-	Csa1
WLSH3_k127_7228219_3	1341646.CBMO010000145_gene4938	0.0001477	46.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,23535@1762|Mycobacteriaceae	201174|Actinobacteria	S	Modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_7228219_0	400682.PAC_15721538	5.914e-75	266.0	KOG0739@1|root,KOG0739@2759|Eukaryota,38D1Q@33154|Opisthokonta,3BCY8@33208|Metazoa	33208|Metazoa	O	positive regulation of centriole elongation	Vps4	GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0003002,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0006508,GO:0006511,GO:0006807,GO:0006914,GO:0006996,GO:0007010,GO:0007163,GO:0007275,GO:0007389,GO:0007399,GO:0007423,GO:0007610,GO:0007638,GO:0008104,GO:0008150,GO:0008152,GO:0008593,GO:0009056,GO:0009057,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009887,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010008,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0016020,GO:0016043,GO:0016236,GO:0016322,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0021700,GO:0022008,GO:0022411,GO:0023051,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030154,GO:0030163,GO:0030182,GO:0031090,GO:0031410,GO:0031982,GO:0032501,GO:0032502,GO:0032984,GO:0032991,GO:0033036,GO:0034613,GO:0035088,GO:0035418,GO:0036452,GO:0040008,GO:0042051,GO:0042058,GO:0042461,GO:0042462,GO:0042551,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043632,GO:0043900,GO:0043901,GO:0043903,GO:0043933,GO:0044126,GO:0044130,GO:0044144,GO:0044146,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045197,GO:0045463,GO:0045465,GO:0045470,GO:0045742,GO:0045746,GO:0045926,GO:0046530,GO:0048468,GO:0048469,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048592,GO:0048666,GO:0048699,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051603,GO:0051641,GO:0061245,GO:0061919,GO:0065007,GO:0070727,GO:0071695,GO:0071704,GO:0071840,GO:0072657,GO:0090596,GO:0097352,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:1901184,GO:1901186,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1903539,GO:1904949,GO:1990621,GO:1990778	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
WLSH3_k127_7228219_1	6412.HelroP156379	4.647e-05	53.0	KOG4068@1|root,KOG4068@2759|Eukaryota,39S7B@33154|Opisthokonta,3B9CD@33208|Metazoa,3CVUB@33213|Bilateria	33208|Metazoa	H	Vacuolar protein-sorting-associated protein 25	VPS25	GO:0000003,GO:0000578,GO:0000814,GO:0001894,GO:0001932,GO:0001933,GO:0002009,GO:0002165,GO:0003002,GO:0003006,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006403,GO:0006469,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006897,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007163,GO:0007175,GO:0007176,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0007444,GO:0007483,GO:0007484,GO:0007485,GO:0007548,GO:0007552,GO:0007560,GO:0008104,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009653,GO:0009790,GO:0009791,GO:0009798,GO:0009880,GO:0009886,GO:0009887,GO:0009888,GO:0009892,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010469,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010669,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0019220,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022411,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030011,GO:0030154,GO:0030163,GO:0030539,GO:0031090,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032984,GO:0032991,GO:0033036,GO:0033365,GO:0033673,GO:0034613,GO:0035088,GO:0035090,GO:0035112,GO:0035126,GO:0035215,GO:0035239,GO:0035282,GO:0035295,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042127,GO:0042325,GO:0042326,GO:0042592,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043086,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043549,GO:0043632,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045184,GO:0045197,GO:0045199,GO:0045324,GO:0045450,GO:0045859,GO:0045936,GO:0046661,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048519,GO:0048523,GO:0048563,GO:0048569,GO:0048583,GO:0048585,GO:0048599,GO:0048608,GO:0048609,GO:0048707,GO:0048729,GO:0048731,GO:0048803,GO:0048805,GO:0048806,GO:0048808,GO:0048856,GO:0048869,GO:0048871,GO:0050678,GO:0050680,GO:0050730,GO:0050732,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0060249,GO:0060255,GO:0060429,GO:0060562,GO:0060810,GO:0060811,GO:0061097,GO:0061099,GO:0061245,GO:0061458,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070086,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090598,GO:0097352,GO:0097708,GO:0098588,GO:0098657,GO:0098796,GO:0098805,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:2000272	-	ko:K12189	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	ESCRT-II
WLSH3_k127_7228219_2	4536.ONIVA09G18320.1	0.0001212	48.0	KOG3341@1|root,KOG3341@2759|Eukaryota	2759|Eukaryota	K	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	SNF8	GO:0000003,GO:0000429,GO:0000430,GO:0000433,GO:0000578,GO:0000741,GO:0000742,GO:0000746,GO:0000747,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0006914,GO:0006996,GO:0006997,GO:0007032,GO:0007034,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0007584,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009605,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0016604,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0033620,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0044764,GO:0045013,GO:0045014,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045892,GO:0045921,GO:0045934,GO:0045990,GO:0046015,GO:0046618,GO:0046907,GO:0046983,GO:0047485,GO:0048284,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0051716,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0061984,GO:0061985,GO:0061986,GO:0061987,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070887,GO:0070925,GO:0071496,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:1904669,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
WLSH3_k127_7264755_1	1415774.U728_3106	1.743e-23	102.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
WLSH3_k127_7264755_0	1173026.Glo7428_4232	2.137e-96	332.0	COG0402@1|root,COG0402@2|Bacteria,1G37S@1117|Cyanobacteria	1117|Cyanobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
WLSH3_k127_7273035_0	933801.Ahos_0748	1.531e-251	796.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WLSH3_k127_7273035_1	309801.trd_A0909	9.275e-33	136.0	COG0500@1|root,COG2226@2|Bacteria,2G6T6@200795|Chloroflexi,27YB5@189775|Thermomicrobia	189775|Thermomicrobia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
WLSH3_k127_7273035_2	1379698.RBG1_1C00001G0927	3.447e-18	90.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
WLSH3_k127_7273035_3	1172180.KB911776_gene792	5.767e-06	58.0	COG0449@1|root,COG0449@2|Bacteria,2IDZH@201174|Actinobacteria	201174|Actinobacteria	M	SIS domain	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
WLSH3_k127_7273737_1	880071.Fleli_3427	5.975e-15	79.0	2EIVC@1|root,33CKQ@2|Bacteria,4NY8R@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7273737_0	269797.Mbar_A2330	7.406e-47	178.0	COG0500@1|root,arCOG01773@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_7294390_4	269084.syc0207_c	4.456e-12	70.0	COG0713@1|root,COG0713@2|Bacteria,1G6KK@1117|Cyanobacteria,1H0Q8@1129|Synechococcus	1117|Cyanobacteria	C	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration	ndhE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K05576	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_q2
WLSH3_k127_7294390_2	387631.Asulf_01801	2.885e-21	100.0	COG0852@1|root,arCOG01551@2157|Archaea,2XZK1@28890|Euryarchaeota	28890|Euryarchaeota	C	NADH ubiquinone oxidoreductase 27 kD subunit	-	-	1.5.98.3,1.6.5.3	ko:K00332,ko:K22160	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Complex1_30kDa
WLSH3_k127_7294390_0	374847.Kcr_0139	1.089e-66	243.0	COG0649@1|root,arCOG01548@2157|Archaea	2157|Archaea	C	COG0852 NADH ubiquinone oxidoreductase 27 kD subunit	nuoD	-	1.1.98.4,1.6.5.3	ko:K00333,ko:K13378,ko:K22172,ko:K22173	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
WLSH3_k127_7294390_1	86416.Clopa_2009	1.117e-56	214.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,36EBY@31979|Clostridiaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
WLSH3_k127_7294390_3	330214.NIDE0231	1.579e-14	78.0	COG1143@1|root,COG1143@2|Bacteria,3J0N0@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
WLSH3_k127_7307924_1	1287276.X752_22365	4.397e-70	245.0	COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,2TSH8@28211|Alphaproteobacteria,43MYJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
WLSH3_k127_7307924_0	756499.Desde_0778	9.008e-72	258.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
WLSH3_k127_7307924_2	96561.Dole_0769	0.0002646	46.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2X5UF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_7327899_1	247490.KSU1_C0203	4.316e-91	315.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
WLSH3_k127_7327899_0	572547.Amico_0493	2.876e-103	337.0	COG2406@1|root,COG2406@2|Bacteria,3TBV6@508458|Synergistetes	508458|Synergistetes	S	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
WLSH3_k127_7327899_2	342949.PNA2_1601	2.722e-10	62.0	COG0735@1|root,arCOG01868@2157|Archaea,2Y1GV@28890|Euryarchaeota,245J3@183968|Thermococci	183968|Thermococci	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
WLSH3_k127_7395118_0	644281.MFS40622_1394	1.291e-88	302.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23QG1@183939|Methanococci	183939|Methanococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	Intein_splicing,TFIIB,TF_Zn_Ribbon
WLSH3_k127_7395118_1	391623.TERMP_00805	5.864e-18	91.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
WLSH3_k127_7415616_1	743719.PaelaDRAFT_3980	4.971e-44	165.0	COG0454@1|root,COG0456@2|Bacteria,1V2CK@1239|Firmicutes,4HGP5@91061|Bacilli,26WI0@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yyaR	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_7415616_0	673860.AciM339_1147	2.543e-67	235.0	COG1838@1|root,arCOG04406@2157|Archaea,2XXBQ@28890|Euryarchaeota,3F2QU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
WLSH3_k127_7415616_2	374847.Kcr_0093	9.151e-23	99.0	COG1951@1|root,arCOG04407@2157|Archaea	2157|Archaea	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01677,ko:K03779	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
WLSH3_k127_7420467_0	1070774.J07HN4v3_02146	3.442e-72	256.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,23SVV@183963|Halobacteria	183963|Halobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
WLSH3_k127_7420467_1	1365176.N186_01615	5.055e-60	217.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
WLSH3_k127_7420467_2	1382306.JNIM01000001_gene3000	3.2e-34	135.0	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_7441726_6	177439.DP1011	8.843e-07	53.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RJZ@68525|delta/epsilon subdivisions,2WND6@28221|Deltaproteobacteria,2MK4Q@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
WLSH3_k127_7441726_2	177437.HRM2_17530	4.514e-126	415.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_7441726_3	351160.RCIX276	1.333e-60	218.0	COG0266@1|root,2N57K@2157|Archaea	2157|Archaea	L	Formamidopyrimidine-DNA glycosylase N-terminal domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
WLSH3_k127_7441726_4	1173264.KI913949_gene3839	4.779e-32	129.0	COG0662@1|root,COG0662@2|Bacteria,1G5PK@1117|Cyanobacteria,1HC1C@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_7441726_1	264732.Moth_1287	2.586e-130	426.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,42FP2@68295|Thermoanaerobacterales	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
WLSH3_k127_7441726_0	309799.DICTH_0189	4.453e-135	443.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
WLSH3_k127_7441726_5	1123288.SOV_5c00900	8.522e-25	111.0	COG2020@1|root,COG2020@2|Bacteria,1V495@1239|Firmicutes	1239|Firmicutes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_7462102_2	273057.SSO0060	1.665e-32	139.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
WLSH3_k127_7462102_0	1229909.NSED_07730	4.161e-101	342.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
WLSH3_k127_7462102_1	633148.Tagg_0787	1.991e-65	239.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
WLSH3_k127_7474434_1	573413.Spirs_2671	2.236e-12	72.0	COG1744@1|root,COG1744@2|Bacteria,2JA7Q@203691|Spirochaetes	2|Bacteria	M	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
WLSH3_k127_7474434_0	273068.TTE2131	2.191e-101	341.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
WLSH3_k127_7500970_0	391623.TERMP_00208	1.085e-203	651.0	COG1274@1|root,arCOG05865@2157|Archaea,2XUU1@28890|Euryarchaeota,24380@183968|Thermococci	183968|Thermococci	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
WLSH3_k127_7500970_1	469378.Ccur_05280	9.533e-10	63.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,4CUV8@84998|Coriobacteriia	84998|Coriobacteriia	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
WLSH3_k127_7525038_0	572547.Amico_1777	1.107e-48	196.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_7525038_1	1120948.KB903217_gene1289	1.713e-06	59.0	COG1695@1|root,COG1695@2|Bacteria,2HRHM@201174|Actinobacteria,4E6XM@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_7525038_2	1688.BCUN_2109	4.766e-06	57.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2GJTZ@201174|Actinobacteria,4CZIE@85004|Bifidobacteriales	201174|Actinobacteria	MV	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_7534281_0	926569.ANT_18080	2.503e-241	756.0	COG0021@1|root,COG0021@2|Bacteria,2G63Z@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
WLSH3_k127_7534281_9	931277.C448_04734	0.0001084	52.0	COG3413@1|root,arCOG02389@1|root,arCOG02278@2157|Archaea,arCOG02389@2157|Archaea,2XTUJ@28890|Euryarchaeota,23T3W@183963|Halobacteria	183963|Halobacteria	T	sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HTH_10,PAS_4,Response_reg
WLSH3_k127_7534281_3	1191523.MROS_0720	1.539e-65	237.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	CP_1064	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_7534281_4	368408.Tpen_1546	1.367e-53	200.0	arCOG10919@1|root,arCOG10919@2157|Archaea	368408.Tpen_1546|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7534281_7	357808.RoseRS_3392	1.44e-12	79.0	COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
WLSH3_k127_7534281_8	443255.SCLAV_3714	1.977e-08	64.0	COG2146@1|root,COG2146@2|Bacteria,2IFJ5@201174|Actinobacteria	201174|Actinobacteria	P	TQO small subunit DoxD	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX,Rieske
WLSH3_k127_7534281_5	1459636.NTE_00077	1.792e-53	204.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
WLSH3_k127_7534281_6	693661.Arcve_0056	5.238e-37	145.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
WLSH3_k127_7534281_1	243274.THEMA_08515	5.76e-186	597.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GC9M@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	POR,POR_N
WLSH3_k127_7534281_2	868131.MSWAN_0191	2.706e-110	362.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,23PWY@183925|Methanobacteria	183925|Methanobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
WLSH3_k127_7534398_4	330214.NIDE0852	2.939e-36	147.0	COG0644@1|root,COG0644@2|Bacteria,3J0UE@40117|Nitrospirae	40117|Nitrospirae	C	oxidoreductase	-	-	1.3.1.111,1.3.1.83	ko:K10960	ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R11226,R11518	RC00212,RC00522,RC01823	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
WLSH3_k127_7534398_0	1122921.KB898186_gene4949	3.63e-66	239.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,4HD98@91061|Bacilli,274UM@186822|Paenibacillaceae	91061|Bacilli	EJ	Asparaginase	ansA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
WLSH3_k127_7534398_5	3218.PP1S275_101V6.1	4.582e-10	71.0	KOG0076@1|root,KOG0076@2759|Eukaryota,37I4N@33090|Viridiplantae,3G7R4@35493|Streptophyta	35493|Streptophyta	U	Belongs to the small GTPase superfamily. Arf family	-	-	-	ko:K07952	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
WLSH3_k127_7534398_3	694429.Pyrfu_1972	4.796e-39	150.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
WLSH3_k127_7534398_2	453591.Igni_0181	4.05e-43	166.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
WLSH3_k127_7534398_1	604354.TSIB_0341	2.54e-55	196.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,243ZQ@183968|Thermococci	183968|Thermococci	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
WLSH3_k127_7534398_6	439481.Aboo_0872	3.248e-06	56.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX3W@28890|Euryarchaeota,3F3AP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	M protein trans-acting positive regulator (MGA) HTH domain	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
WLSH3_k127_7534402_4	195522.BD01_2200	2.48e-07	53.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y6ET@28890|Euryarchaeota,244B9@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_7534402_3	269797.Mbar_A3229	3.155e-17	89.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
WLSH3_k127_7534402_2	374847.Kcr_1196	1.718e-17	85.0	COG4830@1|root,arCOG04305@2157|Archaea	2157|Archaea	J	PFAM Ribosomal protein S26e	rps26e	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
WLSH3_k127_7534402_0	370438.PTH_2033	1.529e-59	219.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,24AAC@186801|Clostridia,260MS@186807|Peptococcaceae	186801|Clostridia	BQ	histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
WLSH3_k127_7534402_1	797210.Halxa_1786	7.897e-21	107.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23SC2@183963|Halobacteria	183963|Halobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
WLSH3_k127_7555965_5	1094980.Mpsy_1623	1.51e-08	61.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2N941@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
WLSH3_k127_7555965_3	178306.PAE3595	9.153e-39	151.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
WLSH3_k127_7555965_1	378806.STAUR_7200	8.752e-86	299.0	COG1032@1|root,COG1032@2|Bacteria,1RF63@1224|Proteobacteria,42S8Y@68525|delta/epsilon subdivisions,2WNX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
WLSH3_k127_7555965_0	673860.AciM339_0566	5.952e-90	308.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,3F2ET@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
WLSH3_k127_7555965_4	552811.Dehly_0767	1.042e-36	147.0	COG2178@1|root,COG2178@2|Bacteria,2G6RW@200795|Chloroflexi,34CS2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_7555965_2	529709.PYCH_10250	4.3e-39	153.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,242U9@183968|Thermococci	183968|Thermococci	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,HTH_27,HTH_Crp_2,MarR_2
WLSH3_k127_7557468_4	1128421.JAGA01000001_gene2345	0.0009671	50.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CARDB,CBM_3,DUF4091,HYR,Kelch_1,MAM,PA14,PKD,Peptidase_M43,Reprolysin_3
WLSH3_k127_7557468_1	1459636.NTE_01818	3.662e-24	107.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
WLSH3_k127_7557468_2	335543.Sfum_0018	4.603e-16	83.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MS46@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
WLSH3_k127_7557468_0	573063.Metin_0090	3.248e-126	415.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23RI4@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_7562545_0	1121472.AQWN01000011_gene1255	5.479e-176	566.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,26167@186807|Peptococcaceae	186801|Clostridia	C	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
WLSH3_k127_7562545_1	1121405.dsmv_1298	8.368e-127	416.0	COG1032@1|root,COG1032@2|Bacteria,1PTN9@1224|Proteobacteria,42MG9@68525|delta/epsilon subdivisions,2WJYU@28221|Deltaproteobacteria,2MIRY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_7566520_1	1249997.JHZW01000002_gene1982	2.669e-06	56.0	COG0526@1|root,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1I2TH@117743|Flavobacteriia,2PISD@252356|Maribacter	976|Bacteroidetes	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
WLSH3_k127_7566520_0	562970.Btus_1876	1.376e-15	81.0	COG1733@1|root,COG1733@2|Bacteria,1VH3Q@1239|Firmicutes,4HNMI@91061|Bacilli,27A93@186823|Alicyclobacillaceae	91061|Bacilli	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
WLSH3_k127_7569371_0	5808.XP_002142094.1	0.0004618	50.0	KOG0096@1|root,KOG0096@2759|Eukaryota,3Y9Q8@5794|Apicomplexa,3YMG8@5796|Coccidia	5794|Apicomplexa	U	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle	-	-	-	ko:K07936	ko03008,ko03013,ko05166,ko05169,map03008,map03013,map05166,map05169	-	-	-	ko00000,ko00001,ko03009,ko03016,ko03019,ko03036,ko04031,ko04147	-	-	-	Ras
WLSH3_k127_7592854_0	572546.Arcpr_1414	4.074e-35	142.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2465V@183980|Archaeoglobi	183980|Archaeoglobi	S	Zinc finger domain	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
WLSH3_k127_7603246_1	498848.TaqDRAFT_4226	1.353e-28	134.0	COG0318@1|root,COG0318@2|Bacteria,1WIAG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_7603246_0	941824.TCEL_01558	4.238e-144	486.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
WLSH3_k127_7644377_0	358681.BBR47_09910	7.38e-43	160.0	28IGK@1|root,2Z8I1@2|Bacteria,1VS1R@1239|Firmicutes,4HUED@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7654601_0	511051.CSE_08820	2.076e-71	256.0	COG1251@1|root,COG1251@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015044,GO:0016491,GO:0016730,GO:0016731,GO:0017144,GO:0022900,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0072592,GO:0097159,GO:1901265,GO:1901363	1.6.3.4,1.7.1.15	ko:K00362,ko:K02192,ko:K22405	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Flavodoxin_1,Lactamase_B,Pyr_redox_2
WLSH3_k127_7654601_1	1457250.BBMO01000001_gene580	7.367e-09	66.0	COG1011@1|root,arCOG02291@2157|Archaea,2XXMA@28890|Euryarchaeota,23VH3@183963|Halobacteria	183963|Halobacteria	S	subfamily IA, variant 1	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
WLSH3_k127_7685245_2	357808.RoseRS_2615	1.171e-09	72.0	COG2170@1|root,COG2170@2|Bacteria,2G5NR@200795|Chloroflexi,375BI@32061|Chloroflexia	32061|Chloroflexia	F	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
WLSH3_k127_7685245_0	439481.Aboo_0845	1.774e-110	367.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
WLSH3_k127_7685245_1	439481.Aboo_0844	3.428e-68	236.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,3F39K@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_7690865_9	1120949.KB903304_gene6942	2.69e-09	67.0	COG0546@1|root,COG0546@2|Bacteria,2IHMV@201174|Actinobacteria,4DCVA@85008|Micromonosporales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
WLSH3_k127_7690865_6	1279038.KB907344_gene3529	1.419e-14	86.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,2JPRT@204441|Rhodospirillales	204441|Rhodospirillales	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
WLSH3_k127_7690865_5	1385511.N783_07720	4.097e-23	109.0	COG0491@1|root,COG0491@2|Bacteria,1TR4H@1239|Firmicutes,4HBXR@91061|Bacilli,2YAAY@289201|Pontibacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_7690865_0	439481.Aboo_0713	1.834e-111	373.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,3F37E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
WLSH3_k127_7690865_10	231434.JQJH01000001_gene1950	2.739e-08	65.0	COG0500@1|root,COG2226@2|Bacteria,1REUM@1224|Proteobacteria,2U75Q@28211|Alphaproteobacteria,3NBXN@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	btaB	-	-	ko:K13623	ko00564,map00564	-	R09073	RC00003,RC02308	ko00000,ko00001	-	-	-	Methyltransf_23,Methyltransf_25
WLSH3_k127_7690865_3	1365176.N186_04470	4.803e-34	145.0	COG2219@1|root,arCOG03013@2157|Archaea,2XQ8M@28889|Crenarchaeota	28889|Crenarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
WLSH3_k127_7690865_1	1455608.JDTH01000002_gene554	7.99e-57	209.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,23S1T@183963|Halobacteria	183963|Halobacteria	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	ogg	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
WLSH3_k127_7690865_4	548477.HMPREF0294_0332	1.215e-32	146.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
WLSH3_k127_7690865_7	1396141.BATP01000045_gene1848	2.552e-13	83.0	COG2911@1|root,COG3866@1|root,COG4932@1|root,COG5267@1|root,COG2911@2|Bacteria,COG3866@2|Bacteria,COG4932@2|Bacteria,COG5267@2|Bacteria,46TJE@74201|Verrucomicrobia,2IVHT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
WLSH3_k127_7690865_8	314231.FP2506_17984	1.216e-12	76.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2U5T0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
WLSH3_k127_7690865_2	693661.Arcve_1931	2.769e-50	186.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2460M@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_7694140_1	266117.Rxyl_0295	5.252e-122	407.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4CR8G@84995|Rubrobacteria	84995|Rubrobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
WLSH3_k127_7694140_0	1074488.AGBX01000001_gene243	8.579e-147	484.0	COG1027@1|root,COG1027@2|Bacteria,2I2HG@201174|Actinobacteria,4FBX3@85020|Dermabacteraceae	201174|Actinobacteria	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1,cNMP_binding
WLSH3_k127_7694140_2	237368.SCABRO_02097	5.235e-26	112.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx
WLSH3_k127_7715962_0	1047013.AQSP01000067_gene2204	1.588e-75	263.0	COG0436@1|root,COG0436@2|Bacteria,2NR19@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_7715962_1	1209989.TepiRe1_2517	5.923e-40	158.0	COG0765@1|root,COG0765@2|Bacteria,1TPQ8@1239|Firmicutes,25C2R@186801|Clostridia	186801|Clostridia	P	acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
WLSH3_k127_7715962_2	1121441.AUCX01000022_gene817	1.093e-09	60.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2M7ZW@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
WLSH3_k127_7746127_0	891968.Anamo_1805	1.365e-56	211.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_7746127_1	351160.LRC377	2.456e-20	95.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_7746580_0	1094980.Mpsy_1520	9.772e-29	135.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,2N92I@224756|Methanomicrobia	224756|Methanomicrobia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
WLSH3_k127_7748769_0	647113.Metok_0123	9.289e-33	143.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
WLSH3_k127_7748769_1	768672.Desfe_0320	2.614e-22	100.0	COG0520@1|root,arCOG00065@2157|Archaea,2XQ57@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	csd	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
WLSH3_k127_7781597_0	1365176.N186_01885	8.776e-27	117.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
WLSH3_k127_7826726_1	649747.HMPREF0083_03334	3.95e-37	147.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,4H9VY@91061|Bacilli,26RI3@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the formation of phosphoenolpyruvate from pyruvate	pyk	GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
WLSH3_k127_7826726_0	579137.Metvu_0880	2.718e-90	306.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,23QEM@183939|Methanococci	183939|Methanococci	M	PFAM UDP-N-acetylglucosamine 2-epimerase	-	GO:0003674,GO:0003824,GO:0008761,GO:0016853,GO:0016854,GO:0016857	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
WLSH3_k127_7831507_0	1184251.TCELL_1207	1.39e-51	195.0	COG0601@1|root,arCOG00751@2157|Archaea,2XQNC@28889|Crenarchaeota	28889|Crenarchaeota	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_7831507_1	416591.Tlet_1438	1.466e-08	64.0	COG0747@1|root,COG0747@2|Bacteria,2GCPN@200918|Thermotogae	200918|Thermotogae	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_7864048_4	1070774.J07HN4v3_01517	7.33e-05	53.0	2DZAE@1|root,2N5T3@2157|Archaea,2Y3PF@28890|Euryarchaeota,23ZME@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7864048_2	387631.Asulf_01218	3.272e-47	172.0	COG2033@1|root,arCOG02146@2157|Archaea,2Y3EA@28890|Euryarchaeota	28890|Euryarchaeota	C	Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide	sorA	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
WLSH3_k127_7864048_1	523845.AQXV01000038_gene1117	1.062e-88	311.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,23QKS@183939|Methanococci	183939|Methanococci	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_7864048_3	368408.Tpen_1668	9.829e-31	131.0	COG4720@1|root,arCOG05752@2157|Archaea,2XQ9C@28889|Crenarchaeota	28889|Crenarchaeota	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
WLSH3_k127_7864048_0	1499967.BAYZ01000180_gene4413	1.227e-158	514.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7880439_3	1499967.BAYZ01000022_gene220	1.035e-10	67.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_7880439_2	557599.MKAN_03715	5.81e-67	240.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
WLSH3_k127_7880439_4	673860.AciM339_1366	0.0001189	51.0	COG3255@1|root,arCOG01843@2157|Archaea,2Y75B@28890|Euryarchaeota,3F3F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_7880439_0	429009.Adeg_1885	1.541e-147	490.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
WLSH3_k127_7917193_1	318464.IO99_07525	1.931e-15	86.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
WLSH3_k127_7918351_0	82508.K1VQV2	2.469e-12	73.0	COG1053@1|root,COG3569@1|root,KOG0981@2759|Eukaryota,KOG2403@2759|Eukaryota,38C2E@33154|Opisthokonta,3NUJJ@4751|Fungi,3V04F@5204|Basidiomycota,3VDNZ@5234|Tremellales	4751|Fungi	L	DNA Topoisomerase I (eukaryota)	TOP1	GO:0000018,GO:0000019,GO:0000070,GO:0000183,GO:0000228,GO:0000278,GO:0000280,GO:0000785,GO:0000790,GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006265,GO:0006271,GO:0006323,GO:0006325,GO:0006333,GO:0006338,GO:0006342,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006725,GO:0006807,GO:0006810,GO:0006996,GO:0007049,GO:0007059,GO:0007076,GO:0007097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016458,GO:0016853,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022402,GO:0022616,GO:0030261,GO:0031298,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0040029,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046907,GO:0048285,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051276,GO:0051640,GO:0051641,GO:0051647,GO:0051649,GO:0051656,GO:0060255,GO:0065007,GO:0070013,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098813,GO:0140014,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903047,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
WLSH3_k127_7920219_1	446462.Amir_2848	2.259e-52	196.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_7920219_10	386456.JQKN01000002_gene2403	1.326e-19	89.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
WLSH3_k127_7920219_11	1459636.NTE_02161	3.038e-13	72.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
WLSH3_k127_7920219_9	679926.Mpet_2655	2.037e-26	114.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,2N9WM@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
WLSH3_k127_7920219_6	330779.Saci_0263	4.62e-30	139.0	COG1204@1|root,arCOG00553@2157|Archaea,2XPUH@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
WLSH3_k127_7920219_0	69014.TK1428	1.772e-225	715.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,243E8@183968|Thermococci	183968|Thermococci	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
WLSH3_k127_7920219_2	573063.Metin_1190	5.938e-52	191.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23QK3@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
WLSH3_k127_7920219_5	1459636.NTE_02621	4.264e-36	150.0	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
WLSH3_k127_7920219_7	195522.BD01_1511	4.221e-29	124.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
WLSH3_k127_7920219_3	269797.Mbar_A3234	2.332e-46	178.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
WLSH3_k127_7920219_4	589924.Ferp_0274	2.959e-44	168.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,246VN@183980|Archaeoglobi	183980|Archaeoglobi	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
WLSH3_k127_7920219_12	224719.Abm4_1659	2.255e-08	59.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,23P6P@183925|Methanobacteria	183925|Methanobacteria	K	RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
WLSH3_k127_7920219_8	246969.TAM4_962	9.148e-27	111.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,244BJ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
WLSH3_k127_7983204_1	1519464.HY22_06365	3.664e-47	185.0	COG0438@1|root,COG0438@2|Bacteria,1FE81@1090|Chlorobi	1090|Chlorobi	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
WLSH3_k127_7983204_0	595460.RRSWK_05623	6.025e-104	350.0	COG0451@1|root,COG0451@2|Bacteria,2IX9F@203682|Planctomycetes	203682|Planctomycetes	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
WLSH3_k127_8014957_7	868131.MSWAN_0491	0.0001892	51.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,23NMN@183925|Methanobacteria	183925|Methanobacteria	L	DHHA1 domain	recJ2	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
WLSH3_k127_8014957_1	186497.PF0022	1.104e-64	240.0	COG1530@1|root,arCOG04307@2157|Archaea,2XUGB@28890|Euryarchaeota,243F3@183968|Thermococci	183968|Thermococci	J	Binds to RNA in loop regions with AU-rich sequences	aubA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K22469	-	-	-	-	ko00000,ko03009	-	-	-	DUF402,RNase_E_G
WLSH3_k127_8014957_4	415426.Hbut_1631	3.592e-20	93.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
WLSH3_k127_8014957_6	1163730.FFONT_0844	5.78e-07	56.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
WLSH3_k127_8014957_2	673860.AciM339_0403	3.074e-48	182.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,3F2MY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
WLSH3_k127_8014957_5	452637.Oter_3065	1.043e-12	79.0	COG0823@1|root,COG3210@1|root,COG5276@1|root,COG0823@2|Bacteria,COG3210@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	U	domain, Protein	lpqB	-	2.7.13.3	ko:K07654	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3739,Germane,Gmad1,Haemagg_act,LVIVD
WLSH3_k127_8014957_0	391623.TERMP_01660	2.221e-98	338.0	COG1109@1|root,arCOG00767@2157|Archaea,2XTYZ@28890|Euryarchaeota,242U1@183968|Thermococci	183968|Thermococci	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.7	ko:K22199	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WLSH3_k127_8014957_3	1459636.NTE_02598	2.486e-24	113.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
WLSH3_k127_80174_1	373903.Hore_13850	3.359e-33	130.0	COG1573@1|root,COG1573@2|Bacteria,1V1SU@1239|Firmicutes,24E7B@186801|Clostridia	186801|Clostridia	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
WLSH3_k127_80174_0	1229205.BUPH_01376	1.607e-66	242.0	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2VP98@28216|Betaproteobacteria,1K4DI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Winged helix DNA-binding domain	ycaQ	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
WLSH3_k127_80174_2	875328.JDM601_1817	1.303e-21	108.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,2360Z@1762|Mycobacteriaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
WLSH3_k127_80174_3	416348.Hlac_1519	2.514e-07	55.0	COG0784@1|root,arCOG02333@2157|Archaea,2Y7WP@28890|Euryarchaeota,240YM@183963|Halobacteria	183963|Halobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
WLSH3_k127_8055957_0	1191523.MROS_1378	4.231e-55	196.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
WLSH3_k127_8055957_1	44060.JODL01000031_gene1746	6.231e-05	54.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria	201174|Actinobacteria	K	asnC family	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_8088909_1	1041930.Mtc_0820	1.186e-91	314.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2N9FP@224756|Methanomicrobia	224756|Methanomicrobia	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
WLSH3_k127_8088909_2	453591.Igni_0828	4.727e-22	98.0	COG3357@1|root,arCOG04479@2157|Archaea,2XR5D@28889|Crenarchaeota	28889|Crenarchaeota	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_8088909_0	246969.TAM4_453	1.264e-95	327.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,243BB@183968|Thermococci	183968|Thermococci	S	PFAM PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
WLSH3_k127_8089417_1	4155.Migut.D01557.1.p	2.052e-38	149.0	COG1100@1|root,KOG0087@2759|Eukaryota,37J63@33090|Viridiplantae,3GG35@35493|Streptophyta,44DGD@71274|asterids	35493|Streptophyta	U	Rab subfamily of small GTPases	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0012505,GO:0016020,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097708	-	ko:K07976	-	-	-	-	ko00000,ko04031	-	-	-	Ras
WLSH3_k127_8089417_2	573064.Mefer_1333	3.532e-09	62.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZXK@28890|Euryarchaeota,23R89@183939|Methanococci	183939|Methanococci	O	TIGRFAM redox-active disulfide protein 1	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
WLSH3_k127_8089417_0	391623.TERMP_01671	7.7e-47	179.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
WLSH3_k127_8089417_3	589924.Ferp_1531	4.585e-09	66.0	COG0467@1|root,arCOG01171@2157|Archaea,2XUWH@28890|Euryarchaeota,245RB@183980|Archaeoglobi	183980|Archaeoglobi	T	PFAM Circadian clock protein KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
WLSH3_k127_810912_2	273116.14324398	8.008e-09	64.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2423S@183967|Thermoplasmata	183967|Thermoplasmata	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
WLSH3_k127_810912_1	1499967.BAYZ01000028_gene1315	4.225e-15	87.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
WLSH3_k127_810912_0	386456.JQKN01000007_gene3214	1.477e-54	204.0	COG0573@1|root,arCOG00167@2157|Archaea,2XTYD@28890|Euryarchaeota,23NUX@183925|Methanobacteria	183925|Methanobacteria	P	phosphate transport system	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
WLSH3_k127_8115959_0	3218.PP1S40_202V6.1	5.125e-41	154.0	COG4354@1|root,KOG2119@2759|Eukaryota,37JKE@33090|Viridiplantae,3GEGI@35493|Streptophyta	35493|Streptophyta	G	Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
WLSH3_k127_8115959_1	591157.SSLG_00705	3.987e-05	55.0	COG1522@1|root,COG1522@2|Bacteria,2GN6I@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
WLSH3_k127_8119647_0	868595.Desca_0153	1.333e-99	332.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,260CY@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
WLSH3_k127_8119647_2	1449126.JQKL01000028_gene2585	3.076e-18	92.0	COG2846@1|root,COG2846@2|Bacteria	2|Bacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	DUF1858,Hemerythrin
WLSH3_k127_8119647_1	1214242.B446_33085	7.416e-60	222.0	COG1237@1|root,COG1237@2|Bacteria,2I8H7@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
WLSH3_k127_8119647_3	1089544.KB912942_gene4789	5.052e-09	59.0	COG1454@1|root,COG1454@2|Bacteria,2IIBF@201174|Actinobacteria,4EBSP@85010|Pseudonocardiales	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_8124892_1	502558.EGYY_10820	1.259e-38	161.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria,4CVYU@84998|Coriobacteriia	84998|Coriobacteriia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
WLSH3_k127_8124892_0	697281.Mahau_1472	2.3e-152	495.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,42F0R@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
WLSH3_k127_8155123_0	983544.Lacal_1422	1.857e-34	150.0	COG1541@1|root,COG1541@2|Bacteria,4NFRI@976|Bacteroidetes,1HXCK@117743|Flavobacteriia	976|Bacteroidetes	H	Pfam GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
WLSH3_k127_8169209_0	335543.Sfum_3346	3.047e-20	104.0	COG0438@1|root,COG0438@2|Bacteria,1NET7@1224|Proteobacteria,431AW@68525|delta/epsilon subdivisions,2WWRH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8184489_0	523850.TON_0359	0.0001032	45.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,242WT@183968|Thermococci	183968|Thermococci	M	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
WLSH3_k127_8194555_0	926569.ANT_13300	1.421e-50	190.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2GA77@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9
WLSH3_k127_8194555_1	255470.cbdbA1553	3.619e-12	73.0	COG1846@1|root,COG1846@2|Bacteria,2GAS6@200795|Chloroflexi,34D7U@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8209192_0	1461580.CCAS010000069_gene4058	2.192e-34	139.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HA8K@91061|Bacilli,1ZAYW@1386|Bacillus	91061|Bacilli	V	COG1131 ABC-type multidrug transport system, ATPase component	yfiL	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_8209227_3	382464.ABSI01000011_gene2980	0.0001226	49.0	2C9CZ@1|root,33ZW9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8209227_2	351160.RCIX623	2.987e-47	178.0	COG1335@1|root,arCOG01943@2157|Archaea	2157|Archaea	Q	COG1335 Amidases related to nicotinamidase	entB1	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
WLSH3_k127_8209227_1	1382306.JNIM01000001_gene1633	5.756e-51	193.0	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_8209227_0	132908.ENSPVAP00000011835	5.112e-153	491.0	COG5277@1|root,KOG0676@2759|Eukaryota,38C0D@33154|Opisthokonta,3BBGP@33208|Metazoa,3CRBJ@33213|Bilateria,485B3@7711|Chordata,493M4@7742|Vertebrata,3J3W2@40674|Mammalia,4M2BX@9397|Chiroptera	33208|Metazoa	Z	Actin	ACTA1	GO:0000166,GO:0001725,GO:0003008,GO:0003012,GO:0003674,GO:0005198,GO:0005200,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005865,GO:0005884,GO:0006928,GO:0006936,GO:0006996,GO:0007010,GO:0007015,GO:0007275,GO:0007517,GO:0007519,GO:0008092,GO:0008144,GO:0008150,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009887,GO:0009888,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010226,GO:0010243,GO:0010468,GO:0010604,GO:0010628,GO:0010927,GO:0014070,GO:0014706,GO:0014866,GO:0014888,GO:0014902,GO:0014904,GO:0015629,GO:0016043,GO:0017022,GO:0017076,GO:0019222,GO:0022607,GO:0030016,GO:0030017,GO:0030027,GO:0030029,GO:0030036,GO:0030048,GO:0030049,GO:0030154,GO:0030175,GO:0030239,GO:0030240,GO:0030554,GO:0031032,GO:0031252,GO:0032432,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032989,GO:0032991,GO:0033275,GO:0033993,GO:0035639,GO:0036094,GO:0036379,GO:0042221,GO:0042641,GO:0042692,GO:0042995,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043500,GO:0043501,GO:0043503,GO:0043531,GO:0044085,GO:0044297,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0048468,GO:0048513,GO:0048518,GO:0048545,GO:0048646,GO:0048729,GO:0048731,GO:0048741,GO:0048747,GO:0048856,GO:0048869,GO:0050789,GO:0050896,GO:0051146,GO:0051716,GO:0055001,GO:0055002,GO:0060255,GO:0060485,GO:0060537,GO:0060538,GO:0061061,GO:0065007,GO:0070252,GO:0070887,GO:0070925,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0072132,GO:0090130,GO:0090131,GO:0097159,GO:0097367,GO:0097435,GO:0097517,GO:0098858,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0120025,GO:1901265,GO:1901363,GO:1901698,GO:1901699	-	ko:K05692,ko:K10354,ko:K12313,ko:K12314	ko04015,ko04145,ko04210,ko04260,ko04261,ko04270,ko04371,ko04390,ko04391,ko04510,ko04520,ko04530,ko04611,ko04670,ko04714,ko04745,ko04810,ko04919,ko04921,ko04926,ko05100,ko05110,ko05130,ko05131,ko05132,ko05164,ko05205,ko05225,ko05410,ko05412,ko05414,ko05416,ko05418,map04015,map04145,map04210,map04260,map04261,map04270,map04371,map04390,map04391,map04510,map04520,map04530,map04611,map04670,map04714,map04745,map04810,map04919,map04921,map04926,map05100,map05110,map05130,map05131,map05132,map05164,map05205,map05225,map05410,map05412,map05414,map05416,map05418	-	-	-	ko00000,ko00001,ko03019,ko03021,ko03029,ko03036,ko04147,ko04812	-	-	-	Actin
WLSH3_k127_8254869_0	386456.JQKN01000012_gene1070	2.999e-07	60.0	arCOG08019@1|root,arCOG08019@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
WLSH3_k127_8254869_1	1381751.JAJB01000041_gene3031	1.908e-05	57.0	COG2271@1|root,COG2271@2|Bacteria,2I32P@201174|Actinobacteria,4F9AV@85019|Brevibacteriaceae	201174|Actinobacteria	G	Uncharacterised MFS-type transporter YbfB	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,MFS_4,Sugar_tr
WLSH3_k127_8260285_0	706587.Desti_3979	1.342e-54	201.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15560	OMPdecase,Pribosyltran
WLSH3_k127_8263753_2	1459636.NTE_02126	2.207e-07	53.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
WLSH3_k127_8263753_1	589924.Ferp_1231	1.139e-38	150.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
WLSH3_k127_8263753_0	555079.Toce_0383	1.165e-98	335.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_826384_3	647113.Metok_0814	1.973e-15	79.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZY3@28890|Euryarchaeota,23R9B@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
WLSH3_k127_826384_2	572478.Vdis_1518	2.358e-16	88.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_826384_1	339860.Msp_1357	2.977e-25	107.0	COG1888@1|root,arCOG04140@2157|Archaea,2Y02A@28890|Euryarchaeota,23PQJ@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized ArCR, COG1888	-	-	-	ko:K09732	-	-	-	-	ko00000	-	-	-	DUF211
WLSH3_k127_826384_0	335543.Sfum_4014	3.229e-40	153.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MR11@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
WLSH3_k127_8265215_1	880072.Desac_2119	2.416e-36	146.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria,2MRI3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_8265215_3	1487923.DP73_06490	4.196e-06	52.0	COG1146@1|root,COG1146@2|Bacteria,1W2AI@1239|Firmicutes,25709@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
WLSH3_k127_8265215_0	523845.AQXV01000055_gene101	2.147e-53	200.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,23Q5F@183939|Methanococci	183939|Methanococci	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
WLSH3_k127_8265215_2	1078020.KEK_14828	1.533e-16	84.0	2EX84@1|root,33QIW@2|Bacteria,2ICDC@201174|Actinobacteria	201174|Actinobacteria	S	PEP-utilising enzyme, mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers
WLSH3_k127_826642_0	868131.MSWAN_1710	1.378e-25	109.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
WLSH3_k127_826642_1	401526.TcarDRAFT_2376	1.704e-24	113.0	COG0697@1|root,COG0697@2|Bacteria,1V0DI@1239|Firmicutes,4H4CC@909932|Negativicutes	909932|Negativicutes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_8278720_0	4513.MLOC_59496.1	1.81e-18	96.0	COG0258@1|root,KOG2519@2759|Eukaryota,37MC4@33090|Viridiplantae,3G9DG@35493|Streptophyta,3KQZ5@4447|Liliopsida,3I340@38820|Poales	35493|Streptophyta	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA	FEN1	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
WLSH3_k127_8278720_1	1227487.C474_05275	0.0001184	53.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23TKK@183963|Halobacteria	183963|Halobacteria	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
WLSH3_k127_8297105_0	604354.TSIB_2028	5.84e-29	119.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci	183968|Thermococci	E	Beta-eliminating lyase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
WLSH3_k127_8297105_2	1071085.KK033114_gene145	4.833e-09	64.0	COG3815@1|root,arCOG03949@2157|Archaea,2XZ2C@28890|Euryarchaeota,23X0I@183963|Halobacteria	183963|Halobacteria	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
WLSH3_k127_8297105_3	1198449.ACAM_1528	5.834e-05	50.0	COG3255@1|root,arCOG01843@2157|Archaea,2XS5X@28889|Crenarchaeota	28889|Crenarchaeota	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_8297105_1	574087.Acear_1801	1.203e-18	90.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_8343714_0	768710.DesyoDRAFT_1409	2.237e-61	222.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_8343714_1	446470.Snas_2630	8.257e-08	58.0	COG0697@1|root,COG0697@2|Bacteria,2HQPM@201174|Actinobacteria,4F0A1@85014|Glycomycetales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_8349373_1	269797.Mbar_A1802	4.755e-05	54.0	COG1520@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKV@224756|Methanomicrobia	224756|Methanomicrobia	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NosD,PKD,PQQ_2,PQQ_3
WLSH3_k127_8349373_0	935845.JADQ01000012_gene2697	1.635e-24	106.0	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli,26ZRV@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterized conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
WLSH3_k127_8351284_1	258594.RPA2639	1.184e-13	78.0	COG2345@1|root,COG2345@2|Bacteria,1RIDX@1224|Proteobacteria,2U9M4@28211|Alphaproteobacteria,3K0QD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_8351284_0	429009.Adeg_1700	1.301e-136	447.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
WLSH3_k127_8355883_5	748449.Halha_2385	2.357e-38	158.0	COG4641@1|root,COG4641@2|Bacteria,1VHDC@1239|Firmicutes	1239|Firmicutes	S	Spore maturation protein	cgeB2	-	-	ko:K06320	-	-	-	-	ko00000	-	-	-	DUF3880,Glyco_trans_1_2
WLSH3_k127_8355883_3	269797.Mbar_A0028	2.949e-41	168.0	COG0438@1|root,arCOG01407@2157|Archaea,2XV7U@28890|Euryarchaeota,2N96F@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
WLSH3_k127_8355883_7	1227488.C477_21225	1.793e-28	128.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUUY@28890|Euryarchaeota,23SFG@183963|Halobacteria	183963|Halobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_8355883_1	342949.PNA2_1115	2.341e-61	226.0	COG0297@1|root,COG0438@1|root,arCOG01403@2157|Archaea,arCOG01420@2157|Archaea,2XVAJ@28890|Euryarchaeota,243HN@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_8355883_0	247490.KSU1_C1608	1.938e-67	248.0	COG3379@1|root,COG3379@2|Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
WLSH3_k127_8355883_6	387631.Asulf_00034	1.753e-33	138.0	COG0125@1|root,arCOG01891@2157|Archaea,2Y11Y@28890|Euryarchaeota	28890|Euryarchaeota	F	Thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
WLSH3_k127_8355883_4	387631.Asulf_00033	3.07e-39	159.0	COG0438@1|root,arCOG01407@2157|Archaea	2157|Archaea	M	COG0438 Glycosyltransferase	gth2	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
WLSH3_k127_8355883_2	391623.TERMP_02100	1.797e-47	180.0	COG0463@1|root,arCOG00894@2157|Archaea,2XVRD@28890|Euryarchaeota,243Z1@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WLSH3_k127_8356562_3	319795.Dgeo_1990	6.463e-09	58.0	COG0565@1|root,COG0565@2|Bacteria,1WJDP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
WLSH3_k127_8356562_1	186497.PF1763	1.278e-90	311.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,242M3@183968|Thermococci	183968|Thermococci	S	gtp1 obg	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
WLSH3_k127_8356562_5	402880.MmarC5_0731	8.387e-07	59.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,23QED@183939|Methanococci	183939|Methanococci	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
WLSH3_k127_8356562_0	1183377.Py04_1586	1.467e-145	477.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
WLSH3_k127_8356562_2	415426.Hbut_0109	1.293e-45	171.0	COG1781@1|root,arCOG04229@2157|Archaea,2XQJR@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
WLSH3_k127_8356562_4	69014.TK1601	1.551e-07	58.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y1TB@28890|Euryarchaeota,244C3@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
WLSH3_k127_836381_1	1220534.B655_0578	3.525e-71	252.0	COG0003@1|root,arCOG02849@2157|Archaea,2XT6V@28890|Euryarchaeota,23NQN@183925|Methanobacteria	183925|Methanobacteria	D	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
WLSH3_k127_836381_2	273063.STK_03510	3.351e-09	58.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
WLSH3_k127_836381_0	694429.Pyrfu_1607	5.743e-110	374.0	COG1032@1|root,arCOG01356@2157|Archaea,2XPY0@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
WLSH3_k127_8378986_1	186497.PF1113	0.0009642	46.0	arCOG02103@1|root,arCOG02103@2157|Archaea,2Y0TZ@28890|Euryarchaeota,243RM@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
WLSH3_k127_8378986_0	1121423.JONT01000032_gene2570	0.000334	50.0	COG4720@1|root,COG4720@2|Bacteria,1V5GD@1239|Firmicutes	1239|Firmicutes	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF-ribofla_trS,ECF_trnsprt
WLSH3_k127_8387449_2	1047013.AQSP01000144_gene916	6.47e-37	141.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
WLSH3_k127_8387449_0	1047013.AQSP01000144_gene915	1.993e-83	284.0	COG0492@1|root,COG0822@1|root,COG0492@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_oxidored,FeS_assembly_P,NifU_N,Pyr_redox_2,cNMP_binding
WLSH3_k127_8387449_4	42099.EPrPV00000013452	4.392e-05	51.0	COG0456@1|root,KOG3138@2759|Eukaryota,1MID2@121069|Pythiales	121069|Pythiales	S	Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_8387449_1	96561.Dole_0760	7.236e-56	200.0	COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
WLSH3_k127_8387449_3	555088.DealDRAFT_2167	1.044e-11	67.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia	186801|Clostridia	KT	PFAM PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	PspC
WLSH3_k127_842597_0	1219626.HMPREF1639_03450	6.244e-109	368.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,25QHI@186804|Peptostreptococcaceae	186801|Clostridia	G	Pyruvate kinase	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
WLSH3_k127_8506945_5	1229909.NSED_02105	4.322e-24	108.0	COG0735@1|root,arCOG01868@2157|Archaea	2157|Archaea	P	transcriptional regulators	fur	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR,PadR
WLSH3_k127_8506945_0	679926.Mpet_2621	1.314e-88	296.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota,2N9HS@224756|Methanomicrobia	224756|Methanomicrobia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
WLSH3_k127_8506945_4	935948.KE386494_gene726	1.901e-25	120.0	COG0438@1|root,COG0457@1|root,COG0463@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0463@2|Bacteria,1TSF5@1239|Firmicutes,25B5G@186801|Clostridia,42ENC@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,TPR_16,TPR_8
WLSH3_k127_8506945_6	868131.MSWAN_2140	5.805e-21	105.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_8506945_2	868131.MSWAN_1563	7.439e-61	224.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,23NUJ@183925|Methanobacteria	183925|Methanobacteria	J	N2,N2-dimethylguanosine tRNA methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
WLSH3_k127_8506945_3	693661.Arcve_0182	1.724e-29	124.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,246DZ@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
WLSH3_k127_8506945_1	415426.Hbut_0632	3.347e-65	231.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
WLSH3_k127_8536466_1	309799.DICTH_1951	1.122e-40	160.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
WLSH3_k127_8536466_0	304371.MCP_1809	6.108e-59	230.0	COG0642@1|root,COG2202@1|root,arCOG02350@1|root,arCOG02352@1|root,arCOG02350@2157|Archaea,arCOG02352@2157|Archaea,arCOG06192@2157|Archaea,arCOG06515@2157|Archaea,2Y7MY@28890|Euryarchaeota,2NAHA@224756|Methanomicrobia	224756|Methanomicrobia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS_3,PAS_4,PAS_9
WLSH3_k127_8536466_3	1120950.KB892754_gene6004	2.897e-07	61.0	COG3832@1|root,COG3832@2|Bacteria,2GNVY@201174|Actinobacteria	201174|Actinobacteria	S	Activator of hsp90 atpase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
WLSH3_k127_8536466_4	91464.S7335_4349	2.738e-06	58.0	COG0170@1|root,COG0170@2|Bacteria,1G25U@1117|Cyanobacteria,1H0MD@1129|Synechococcus	1117|Cyanobacteria	I	Dolichol kinase	-	GO:0003674,GO:0003824,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0006766,GO:0006775,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0010276,GO:0016101,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017144,GO:0018130,GO:0033306,GO:0034308,GO:0042360,GO:0042362,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1903173	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	-
WLSH3_k127_8536466_2	227086.JGI_V11_51880	5.133e-28	121.0	KOG0078@1|root,KOG0078@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	SEC4	GO:0000003,GO:0000131,GO:0000166,GO:0000910,GO:0001411,GO:0001882,GO:0001883,GO:0002790,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005768,GO:0005783,GO:0005886,GO:0005933,GO:0005934,GO:0005935,GO:0005937,GO:0006810,GO:0006887,GO:0006892,GO:0006893,GO:0006903,GO:0006904,GO:0006906,GO:0006914,GO:0006996,GO:0007049,GO:0007107,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009306,GO:0009653,GO:0009987,GO:0010927,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0017157,GO:0019001,GO:0019867,GO:0019953,GO:0022402,GO:0022406,GO:0022413,GO:0022414,GO:0022607,GO:0030133,GO:0030154,GO:0030427,GO:0030435,GO:0030437,GO:0031090,GO:0031321,GO:0031410,GO:0031521,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0031982,GO:0032502,GO:0032505,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032940,GO:0032989,GO:0032991,GO:0033036,GO:0034293,GO:0034613,GO:0035639,GO:0035690,GO:0036094,GO:0042221,GO:0042493,GO:0042886,GO:0042995,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043332,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044703,GO:0045184,GO:0046903,GO:0048193,GO:0048278,GO:0048284,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051179,GO:0051234,GO:0051286,GO:0051301,GO:0051321,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051704,GO:0051716,GO:0060627,GO:0061024,GO:0061025,GO:0061919,GO:0065007,GO:0070727,GO:0070887,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0072659,GO:0090174,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098876,GO:0120025,GO:0120038,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1903046,GO:1903530,GO:1990778	-	ko:K07901	ko04144,ko04152,ko04530,ko04972,map04144,map04152,map04530,map04972	-	-	-	ko00000,ko00001,ko03036,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_8536782_0	118168.MC7420_4960	3.579e-29	134.0	COG0383@1|root,COG0383@2|Bacteria,1G1RB@1117|Cyanobacteria,1H8DG@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Glycosyl hydrolases family 38 C-terminal domain	ams1	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
WLSH3_k127_856146_1	204669.Acid345_1701	5.666e-66	238.0	COG0153@1|root,COG0153@2|Bacteria,3Y300@57723|Acidobacteria,2JI7E@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
WLSH3_k127_856146_0	207954.MED92_00844	6.014e-74	254.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1XH52@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_8577911_1	403833.Pmob_1813	3.206e-16	80.0	COG0334@1|root,COG0334@2|Bacteria,2GCH4@200918|Thermotogae	2|Bacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
WLSH3_k127_8577911_0	593117.TGAM_1352	3.525e-115	387.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8577911_2	1047013.AQSP01000134_gene1334	1.654e-09	69.0	COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8583472_1	1121405.dsmv_1457	2.757e-18	88.0	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MM5C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
WLSH3_k127_8583472_0	330779.Saci_1059	3.115e-33	144.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRTC@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_858636_3	1121423.JONT01000001_gene2161	1.808e-12	79.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,24AKU@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator	-	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_858636_0	1123269.NX02_07250	1.113e-77	280.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,2K117@204457|Sphingomonadales	204457|Sphingomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_858636_2	1459636.NTE_01531	7.401e-15	79.0	COG0662@1|root,arCOG03003@2157|Archaea,41TAC@651137|Thaumarchaeota	651137|Thaumarchaeota	G	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_858636_1	1281779.H009_17898	1.83e-52	195.0	COG0006@1|root,COG0006@2|Bacteria,1MVJK@1224|Proteobacteria,2TVVQ@28211|Alphaproteobacteria,4BNPN@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_8611508_0	186497.PF1670	6.224e-54	205.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
WLSH3_k127_8659488_0	1220534.B655_0150	4.015e-55	205.0	COG2248@1|root,arCOG00969@2157|Archaea,2XW12@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B_2,Lactamase_B_3
WLSH3_k127_8659488_1	394221.Mmar10_0824	1.598e-07	59.0	COG1051@1|root,COG1051@2|Bacteria,1N1XV@1224|Proteobacteria,2UDI0@28211|Alphaproteobacteria,43YA3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH3_k127_8698160_0	1232437.KL661978_gene3851	1.43e-138	451.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_8698160_1	521011.Mpal_1230	7.837e-05	54.0	COG0477@1|root,arCOG00143@2157|Archaea,2XUTR@28890|Euryarchaeota,2N94Q@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
WLSH3_k127_871563_1	1121430.JMLG01000004_gene848	8.183e-07	62.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,248W4@186801|Clostridia,26135@186807|Peptococcaceae	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_871563_0	1416752.AYME01000005_gene1622	4.13e-09	69.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4FQVQ@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_8717487_1	1197130.BAFM01000003_gene698	1.563e-57	205.0	COG0604@1|root,arCOG01458@2157|Archaea,2XU0Q@28890|Euryarchaeota,23SPC@183963|Halobacteria	183963|Halobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor1	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_8717487_0	5762.XP_002676508.1	8.115e-67	243.0	COG1506@1|root,KOG2100@2759|Eukaryota	2759|Eukaryota	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
WLSH3_k127_8730012_0	368408.Tpen_0539	1.692e-79	278.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_8730012_1	292459.STH2315	1.102e-41	170.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_8730326_4	429009.Adeg_0614	2.68e-46	173.0	COG1912@1|root,COG1912@2|Bacteria,1TSR3@1239|Firmicutes,24D3T@186801|Clostridia	186801|Clostridia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
WLSH3_k127_8730326_5	1117958.PE143B_0118760	2.974e-27	125.0	COG0475@1|root,COG0475@2|Bacteria,1QTSD@1224|Proteobacteria,1T1GS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0475 Kef-type K transport systems, membrane components	IV02_22945	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
WLSH3_k127_8730326_6	56780.SYN_02919	5.672e-27	117.0	COG0350@1|root,COG0500@1|root,COG0350@2|Bacteria,COG2226@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
WLSH3_k127_8730326_1	224325.AF_1587	7.719e-160	516.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	28890|Euryarchaeota	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39,5.3.2.5	ko:K01601,ko:K08965	ko00270,ko00630,ko00710,ko01100,ko01120,ko01200,map00270,map00630,map00710,map01100,map01120,map01200	M00034,M00165,M00166,M00532	R00024,R03140,R07393	RC00172,RC00859,RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
WLSH3_k127_8730326_0	1304284.L21TH_0801	2.654e-184	590.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,36EI0@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
WLSH3_k127_8730326_3	264732.Moth_1516	3.347e-86	295.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,42FHP@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
WLSH3_k127_8730326_2	1379698.RBG1_1C00001G1247	1.022e-119	402.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
WLSH3_k127_8730326_7	1166018.FAES_2080	2.184e-22	100.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
WLSH3_k127_8732912_1	720555.BATR1942_16980	3.869e-09	62.0	COG4552@1|root,COG4552@2|Bacteria,1TRPM@1239|Firmicutes,4HD22@91061|Bacilli,1ZB8R@1386|Bacillus	91061|Bacilli	S	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
WLSH3_k127_8732912_0	1121889.AUDM01000013_gene1846	3.962e-177	584.0	COG1061@1|root,COG1061@2|Bacteria,4NIHX@976|Bacteroidetes,1HXVR@117743|Flavobacteriia,2NY6N@237|Flavobacterium	976|Bacteroidetes	V	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
WLSH3_k127_8735734_1	203124.Tery_4498	0.0002278	53.0	COG3391@1|root,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria,1H803@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,TIG,VCBS
WLSH3_k127_8735734_0	926569.ANT_23500	2.412e-79	279.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
WLSH3_k127_8793043_0	1183377.Py04_1449	1.267e-20	99.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,242NX@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8793043_1	760192.Halhy_0975	2.131e-05	57.0	COG0457@1|root,COG4191@1|root,COG0457@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1IQBI@117747|Sphingobacteriia	976|Bacteroidetes	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,TPR_12,TPR_8
WLSH3_k127_8802418_1	1232410.KI421416_gene2685	3.29e-59	213.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WQX0@28221|Deltaproteobacteria,43W25@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K02617,ko:K08279	-	-	-	-	ko00000	-	-	-	Hexapep
WLSH3_k127_8802418_2	386456.JQKN01000001_gene1821	1.148e-13	81.0	COG1668@1|root,arCOG01462@2157|Archaea,2Y3YK@28890|Euryarchaeota	28890|Euryarchaeota	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
WLSH3_k127_8802418_0	351160.LRC208	6.168e-68	243.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_8802418_3	326424.FRAAL5817	7.305e-07	54.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4ET4W@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
WLSH3_k127_8830589_3	368408.Tpen_0281	6.209e-59	208.0	COG0048@1|root,arCOG04255@2157|Archaea,2XQ79@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WLSH3_k127_8830589_2	1365176.N186_02245	1.532e-61	219.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
WLSH3_k127_8830589_1	1379698.RBG1_1C00001G1614	8.598e-109	365.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
WLSH3_k127_8830589_4	1540257.JQMW01000009_gene3474	6.214e-42	159.0	COG0454@1|root,COG0456@2|Bacteria,1VCRG@1239|Firmicutes,24HS4@186801|Clostridia,36JB9@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_8830589_0	368408.Tpen_0647	3.522e-180	573.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
WLSH3_k127_8830589_6	1121438.JNJA01000002_gene3779	3.419e-34	141.0	2DPHF@1|root,33237@2|Bacteria,1R4GY@1224|Proteobacteria,435JT@68525|delta/epsilon subdivisions,2WZY2@28221|Deltaproteobacteria,2M8FU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_8830589_5	453591.Igni_1153	7.378e-36	141.0	COG0328@1|root,arCOG02942@2157|Archaea,2XR72@28889|Crenarchaeota	28889|Crenarchaeota	L	Reverse transcriptase-like	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
WLSH3_k127_8830589_7	694429.Pyrfu_1882	9.705e-06	49.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
WLSH3_k127_8832306_1	400682.PAC_15720459	7.264e-07	58.0	KOG0078@1|root,KOG0078@2759|Eukaryota,39RSX@33154|Opisthokonta,3BJT1@33208|Metazoa	33208|Metazoa	U	RAB13, member RAS oncogene family	RAB13	GO:0000003,GO:0000166,GO:0001525,GO:0001568,GO:0001667,GO:0001882,GO:0001883,GO:0001944,GO:0002064,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0006464,GO:0006807,GO:0006810,GO:0006886,GO:0006928,GO:0006935,GO:0006996,GO:0007010,GO:0007043,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007548,GO:0008104,GO:0008150,GO:0008152,GO:0008406,GO:0008584,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0010033,GO:0010243,GO:0010631,GO:0010737,GO:0010827,GO:0010828,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016328,GO:0016462,GO:0016477,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019897,GO:0019898,GO:0019899,GO:0019900,GO:0019901,GO:0022008,GO:0022414,GO:0022607,GO:0023052,GO:0030027,GO:0030029,GO:0030030,GO:0030036,GO:0030054,GO:0030139,GO:0030141,GO:0030154,GO:0030182,GO:0030659,GO:0030855,GO:0030865,GO:0030866,GO:0031090,GO:0031175,GO:0031252,GO:0031410,GO:0031982,GO:0031984,GO:0032456,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032593,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0033036,GO:0033500,GO:0034236,GO:0034329,GO:0034330,GO:0034613,GO:0034762,GO:0034764,GO:0035239,GO:0035295,GO:0035556,GO:0035639,GO:0035767,GO:0036094,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0042592,GO:0042593,GO:0042886,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043296,GO:0043297,GO:0043412,GO:0043434,GO:0043542,GO:0043687,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044795,GO:0045137,GO:0045184,GO:0045216,GO:0046324,GO:0046326,GO:0046546,GO:0046661,GO:0046907,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048608,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051018,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051674,GO:0051716,GO:0055037,GO:0060008,GO:0060009,GO:0060326,GO:0060429,GO:0061458,GO:0065007,GO:0065008,GO:0070160,GO:0070727,GO:0070830,GO:0070887,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072358,GO:0072359,GO:0072657,GO:0072659,GO:0090130,GO:0090132,GO:0097159,GO:0097367,GO:0097368,GO:0097458,GO:0097708,GO:0098791,GO:0099503,GO:0120025,GO:0120036,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902463,GO:1990778	-	ko:K06109	ko04530,map04530	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_8832306_0	867845.KI911784_gene2719	2.564e-76	276.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
WLSH3_k127_8839263_1	69014.TK0183	1.991e-46	173.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,24333@183968|Thermococci	183968|Thermococci	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
WLSH3_k127_8839263_0	453591.Igni_0070	8.639e-87	302.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
WLSH3_k127_8839263_2	593750.Metfor_2163	5.664e-05	47.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
WLSH3_k127_8847766_0	1121918.ARWE01000001_gene3170	3.519e-108	363.0	COG1520@1|root,COG4886@1|root,COG1520@2|Bacteria,COG4886@2|Bacteria,1PIDG@1224|Proteobacteria,42UM6@68525|delta/epsilon subdivisions,2WPZY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
WLSH3_k127_8874687_0	673860.AciM339_0522	4.783e-08	61.0	arCOG02499@1|root,arCOG02550@1|root,arCOG02499@2157|Archaea,arCOG02550@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD,Pkinase
WLSH3_k127_8876020_0	1121946.AUAX01000058_gene3628	2.264e-28	123.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4D8QG@85008|Micromonosporales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
WLSH3_k127_8876020_2	441769.ABFU01000067_gene2007	2.192e-09	70.0	COG2247@1|root,COG2374@1|root,COG3225@1|root,COG2247@2|Bacteria,COG2374@2|Bacteria,COG3225@2|Bacteria,1UJUI@1239|Firmicutes,4I2BS@91061|Bacilli,1ZCHV@1386|Bacillus	91061|Bacilli	N	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,LTD
WLSH3_k127_8876020_1	1267005.KB911255_gene2683	1.388e-11	77.0	COG0389@1|root,COG0389@2|Bacteria,1NTDH@1224|Proteobacteria,2UNYG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332,Zn_dep_PLPC
WLSH3_k127_8883774_0	1451261.AS96_12230	8.924e-31	140.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
WLSH3_k127_8887687_1	292459.STH1985	1.436e-31	137.0	COG3075@1|root,COG3075@2|Bacteria,1UXV7@1239|Firmicutes,24BVH@186801|Clostridia	186801|Clostridia	C	TIGRFAM Glycerol-3-phosphate dehydrogenase, anaerobic B subunit	glpB	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
WLSH3_k127_8887687_2	1122947.FR7_2376	2.735e-31	138.0	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1TREQ@1239|Firmicutes,4H3PU@909932|Negativicutes	909932|Negativicutes	C	iron-sulfur cluster-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Fer4_9,LUD_dom
WLSH3_k127_8887687_0	278957.ABEA03000186_gene1540	1.977e-115	387.0	COG0277@1|root,COG0277@2|Bacteria,46Y87@74201|Verrucomicrobia,3K93M@414999|Opitutae	414999|Opitutae	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_8887687_3	1128421.JAGA01000001_gene2208	2.11e-13	76.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG
WLSH3_k127_8911919_4	1459636.NTE_00679	6.543e-05	49.0	arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8911919_3	439481.Aboo_1086	2.07e-18	90.0	COG1051@1|root,COG2005@1|root,arCOG00223@2157|Archaea,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,3F39U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH3_k127_8911919_2	411468.CLOSCI_02828	7.699e-20	102.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,21YNG@1506553|Lachnoclostridium	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
WLSH3_k127_8911919_1	573063.Metin_1267	6.681e-86	301.0	COG3276@1|root,arCOG01564@2157|Archaea,2Y862@28890|Euryarchaeota,23QEK@183939|Methanococci	183939|Methanococci	J	elongation factor Tu domain 2 protein	selB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2
WLSH3_k127_8911919_0	267377.MMP0595	4.858e-89	311.0	KOG4482@1|root,arCOG00119@2157|Archaea,2XV24@28890|Euryarchaeota,23Q57@183939|Methanococci	183939|Methanococci	J	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	spcS	-	2.9.1.2	ko:K03341	ko00450,ko00970,map00450,map00970	-	R08224	RC02965,RC02966	ko00000,ko00001,ko01000	-	-	-	SepSecS
WLSH3_k127_8922701_0	646529.Desaci_2651	1.314e-64	238.0	COG0477@1|root,COG0477@2|Bacteria,1UNMW@1239|Firmicutes,25ECT@186801|Clostridia,267FI@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
WLSH3_k127_8922701_1	195522.BD01_0626	6.669e-33	130.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8924167_0	1220534.B655_0522	1.64e-55	200.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,23NYA@183925|Methanobacteria	183925|Methanobacteria	K	RNA polymerase	rpoE1	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
WLSH3_k127_8924167_3	593117.TGAM_0500	8.027e-11	65.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,244KC@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
WLSH3_k127_8924167_1	604354.TSIB_0029	8.303e-15	78.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,244BP@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
WLSH3_k127_8924167_2	419665.Maeo_0284	1.338e-14	74.0	COG1998@1|root,arCOG04183@2157|Archaea,2Y0HV@28890|Euryarchaeota,23R7R@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
WLSH3_k127_8934707_0	96561.Dole_1695	3.595e-73	259.0	COG1145@1|root,COG1145@2|Bacteria,1MW11@1224|Proteobacteria,42NUY@68525|delta/epsilon subdivisions,2WK01@28221|Deltaproteobacteria,2MMY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_8934707_3	1089553.Tph_c13060	6.197e-45	171.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,249SD@186801|Clostridia,42GNM@68295|Thermoanaerobacterales	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
WLSH3_k127_8934707_6	714961.BFZC1_01017	1.038e-05	58.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,3IWNN@400634|Lysinibacillus	91061|Bacilli	EGP	Multidrug transporter	blt	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_8934707_1	1307761.L21SP2_1835	2.759e-68	240.0	COG0483@1|root,COG0483@2|Bacteria,2J924@203691|Spirochaetes	203691|Spirochaetes	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
WLSH3_k127_8934707_4	279010.BL03645	6.105e-33	138.0	COG0454@1|root,COG0456@2|Bacteria,1U521@1239|Firmicutes,4HBEJ@91061|Bacilli,1ZCHR@1386|Bacillus	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	ykwB	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_8934707_5	1321815.HMPREF9193_02094	2.516e-26	123.0	COG1432@1|root,COG1432@2|Bacteria,2J6SB@203691|Spirochaetes	203691|Spirochaetes	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
WLSH3_k127_8934707_2	335543.Sfum_3864	8.246e-53	196.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ldpA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,LdpA_C
WLSH3_k127_8938762_2	272123.Anacy_2209	3.086e-05	51.0	28PSJ@1|root,2ZCE2@2|Bacteria,1G5M8@1117|Cyanobacteria,1HP6T@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
WLSH3_k127_8938762_0	1227500.C494_15318	4.127e-26	116.0	arCOG04041@1|root,arCOG04041@2157|Archaea,arCOG07592@2157|Archaea,2XV04@28890|Euryarchaeota,23U4R@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8938762_1	387631.Asulf_00063	3.036e-22	108.0	arCOG04518@1|root,arCOG04518@2157|Archaea,2XUD7@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,MarR_2,TrmB
WLSH3_k127_8968872_1	1459636.NTE_00846	1.935e-24	113.0	COG1994@1|root,COG3582@1|root,arCOG00614@2157|Archaea,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
WLSH3_k127_8968872_0	161156.JQKW01000010_gene302	1.94e-123	406.0	COG2509@1|root,COG2509@2|Bacteria,2GHIH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	HI0933-like protein	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,Pyr_redox_2
WLSH3_k127_8993742_1	1089553.Tph_c04170	7.588e-33	131.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia,42H3B@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_9
WLSH3_k127_8993742_0	523845.AQXV01000047_gene768	8.674e-55	203.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q7G@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_9012740_0	1121324.CLIT_5c00880	4.404e-82	280.0	COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,24AK0@186801|Clostridia	1239|Firmicutes	S	Threonyl alanyl tRNA synthetase SAD	-	-	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
WLSH3_k127_9012740_1	7209.EJD75622.1	8.244e-06	55.0	KOG1156@1|root,KOG1156@2759|Eukaryota,38EST@33154|Opisthokonta,3B9UM@33208|Metazoa,3CWE0@33213|Bilateria,40BW4@6231|Nematoda,1KUGU@119089|Chromadorea	33208|Metazoa	B	NMDA receptor-regulated protein 1	NAA15	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005667,GO:0005737,GO:0005829,GO:0006355,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010941,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017196,GO:0018193,GO:0018206,GO:0019219,GO:0019222,GO:0019538,GO:0031248,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031365,GO:0031414,GO:0031415,GO:0031647,GO:0032991,GO:0036211,GO:0042981,GO:0043021,GO:0043022,GO:0043066,GO:0043067,GO:0043069,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050821,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051604,GO:0060255,GO:0060548,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:1901564,GO:1902493,GO:1902494,GO:1902680,GO:1903506,GO:1903508,GO:1990234,GO:2000112,GO:2001141	-	ko:K20792	-	-	-	-	ko00000,ko03036	-	-	-	NARP1,TPR_2,TPR_8
WLSH3_k127_9012740_2	526218.Sterm_3847	0.0003777	48.0	COG4978@1|root,COG4978@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
WLSH3_k127_9015156_0	1033743.CAES01000090_gene4090	1.032e-21	104.0	COG3608@1|root,COG3608@2|Bacteria,1UZDT@1239|Firmicutes,4ICZJ@91061|Bacilli,26VG9@186822|Paenibacillaceae	91061|Bacilli	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
WLSH3_k127_9015156_1	1382306.JNIM01000001_gene1809	5.663e-20	95.0	COG1225@1|root,COG1225@2|Bacteria,2G6XD@200795|Chloroflexi	200795|Chloroflexi	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
WLSH3_k127_9015156_2	1500894.JQNN01000001_gene3427	3.716e-15	78.0	COG1122@1|root,COG1122@2|Bacteria,1R0XE@1224|Proteobacteria	1224|Proteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
WLSH3_k127_903513_1	273075.Ta0785	4.659e-13	78.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y1QQ@28890|Euryarchaeota,242HN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
WLSH3_k127_903513_0	1094980.Mpsy_0936	2.515e-48	181.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2N92Q@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
WLSH3_k127_9065115_0	439481.Aboo_0620	2.376e-11	75.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
WLSH3_k127_9065115_1	1514668.JOOA01000002_gene1993	2.061e-07	62.0	COG1670@1|root,COG1670@2|Bacteria,1V4F3@1239|Firmicutes,24EZ6@186801|Clostridia,3WJAU@541000|Ruminococcaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_9074267_0	1229909.NSED_01325	3.699e-105	366.0	COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
WLSH3_k127_9074267_1	1229909.NSED_01320	1.261e-89	314.0	COG1009@1|root,arCOG01539@2157|Archaea,41TBF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
WLSH3_k127_9108164_1	272123.Anacy_4407	6.899e-37	154.0	COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1GQ7S@1117|Cyanobacteria,1HRXM@1161|Nostocales	1117|Cyanobacteria	Q	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347,HemolysinCabind,LVIVD
WLSH3_k127_9108164_0	1002809.SSIL_2466	4.188e-44	165.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,4HIZ3@91061|Bacilli,26HIQ@186818|Planococcaceae	91061|Bacilli	F	dUTPase	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
WLSH3_k127_9111247_1	1487923.DP73_16610	1.449e-16	83.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24ZPQ@186801|Clostridia	186801|Clostridia	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
WLSH3_k127_9111247_0	1123024.AUII01000033_gene1398	5.863e-59	214.0	COG0596@1|root,COG0596@2|Bacteria,2GKT5@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
WLSH3_k127_9111247_2	875454.BAEW01000001_gene9	0.0003578	51.0	28KIX@1|root,2ZA44@2|Bacteria,1UYPD@1239|Firmicutes,24ATH@186801|Clostridia,22GKY@1570339|Peptoniphilaceae	186801|Clostridia	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	phaE	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
WLSH3_k127_9119977_0	1444309.JAQG01000017_gene735	3.622e-63	231.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,26VZV@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase family M28	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
WLSH3_k127_9119977_1	1459636.NTE_02799	7.574e-59	213.0	COG1691@1|root,arCOG02465@2157|Archaea,41SCY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
WLSH3_k127_9140148_0	593750.Metfor_2676	8.854e-70	248.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
WLSH3_k127_9140148_1	96561.Dole_2064	1.11e-22	100.0	COG1148@1|root,COG1148@2|Bacteria,1N26U@1224|Proteobacteria,43BRJ@68525|delta/epsilon subdivisions,2X72E@28221|Deltaproteobacteria,2MPJ6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_9149173_0	1382306.JNIM01000001_gene441	9.653e-42	156.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
WLSH3_k127_9149173_1	1280390.CBQR020000097_gene2196	2.379e-09	66.0	2E6H4@1|root,3314B@2|Bacteria,1VW5U@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9156343_2	1163730.FFONT_0955	3.967e-14	83.0	COG1269@1|root,arCOG04138@2157|Archaea,2XQ7V@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
WLSH3_k127_9156343_0	415426.Hbut_1352	1.623e-51	192.0	COG2519@1|root,arCOG00978@2157|Archaea,2XPU6@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
WLSH3_k127_9156343_1	644281.MFS40622_0134	9.854e-49	194.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota	28890|Euryarchaeota	L	ATPase-like protein	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87,HAS-barrel
WLSH3_k127_9184400_1	1123296.JQKE01000023_gene931	4.965e-07	54.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria,2KREG@206351|Neisseriales	206351|Neisseriales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_9184400_0	667014.Thein_1052	2.03e-61	221.0	COG0535@1|root,COG0535@2|Bacteria,2GI7P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Radical_SAM
WLSH3_k127_9186276_2	926550.CLDAP_07170	9.677e-06	59.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
WLSH3_k127_9186276_0	1128421.JAGA01000003_gene3663	2.686e-36	147.0	arCOG06048@1|root,31EJQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9186276_1	304371.MCP_2737	1.049e-12	75.0	arCOG05710@1|root,arCOG05710@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9191655_0	1267535.KB906767_gene2325	9.971e-78	277.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria,2JIZJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_9248917_2	273068.TTE1217	1.974e-29	120.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
WLSH3_k127_9248917_1	398767.Glov_3258	1.604e-46	171.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
WLSH3_k127_9248917_3	118168.MC7420_1988	1.824e-06	53.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
WLSH3_k127_9248917_0	555079.Toce_0664	3.552e-66	233.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,25J0X@186801|Clostridia,42F6Z@68295|Thermoanaerobacterales	186801|Clostridia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
WLSH3_k127_9257687_0	1410638.JHXJ01000022_gene2240	2.14e-05	53.0	COG1645@1|root,COG1645@2|Bacteria,1TRYG@1239|Firmicutes,25F3V@186801|Clostridia	186801|Clostridia	S	bacterial-type flagellum-dependent swarming motility	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9277171_1	1122915.AUGY01000001_gene7114	4.853e-22	102.0	COG2318@1|root,COG2318@2|Bacteria,1VI69@1239|Firmicutes,4HPG9@91061|Bacilli,26TJI@186822|Paenibacillaceae	91061|Bacilli	S	DinB superfamily	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
WLSH3_k127_9277171_0	1254432.SCE1572_05340	1.808e-51	195.0	COG1305@1|root,COG1305@2|Bacteria,1R9WH@1224|Proteobacteria	1224|Proteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
WLSH3_k127_9279468_1	767817.Desgi_0222	4.009e-21	98.0	29X3G@1|root,30IS5@2|Bacteria,1W5BE@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
WLSH3_k127_9279468_0	67281.JNZZ01000001_gene2043	4.753e-64	227.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,419VP@629295|Streptomyces griseus group	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,DUF4162
WLSH3_k127_9279468_2	1151117.AJLF01000001_gene1053	0.0004171	51.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,243H8@183968|Thermococci	183968|Thermococci	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_929926_0	690850.Desaf_0428	2.077e-34	152.0	COG3266@1|root,COG3391@1|root,COG4870@1|root,COG3266@2|Bacteria,COG3391@2|Bacteria,COG4870@2|Bacteria,1NC9B@1224|Proteobacteria,42Z35@68525|delta/epsilon subdivisions,2WTVH@28221|Deltaproteobacteria,2MD34@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM Peptidase C1A, papain C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
WLSH3_k127_929926_2	1347342.BN863_31370	9.879e-05	55.0	COG1357@1|root,COG2234@1|root,COG1357@2|Bacteria,COG2234@2|Bacteria,4NIQX@976|Bacteroidetes,1I0UI@117743|Flavobacteriia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
WLSH3_k127_929926_1	555779.Dthio_PD2011	1.996e-08	57.0	COG0247@1|root,COG0247@2|Bacteria,1RE3X@1224|Proteobacteria,42RUA@68525|delta/epsilon subdivisions,2WNZF@28221|Deltaproteobacteria,2M8Q8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_8
WLSH3_k127_9299645_0	543526.Htur_2542	3.26e-30	130.0	COG1992@1|root,arCOG00021@2157|Archaea,2XTP7@28890|Euryarchaeota,23SNG@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN2	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
WLSH3_k127_9300533_1	1123009.AUID01000002_gene2168	1.637e-13	74.0	COG0511@1|root,COG0511@2|Bacteria,1VW7S@1239|Firmicutes,25F1E@186801|Clostridia,26CSI@186813|unclassified Clostridiales	186801|Clostridia	I	Biotin-requiring enzyme	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
WLSH3_k127_9300533_0	868131.MSWAN_0895	1.446e-86	301.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,23NRQ@183925|Methanobacteria	183925|Methanobacteria	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
WLSH3_k127_9300533_3	1054217.TALC_00596	0.0008535	47.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_9300533_2	1144275.COCOR_05087	5.305e-05	49.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42QAU@68525|delta/epsilon subdivisions,2WMD2@28221|Deltaproteobacteria,2YUNE@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_9316180_2	1047013.AQSP01000043_gene54	0.0001919	44.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
WLSH3_k127_9316180_0	1121468.AUBR01000048_gene1655	1.336e-184	588.0	COG0520@1|root,COG0520@2|Bacteria,1TQB5@1239|Firmicutes,24D7R@186801|Clostridia,42HYZ@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9316180_1	118166.JH976538_gene5514	3.503e-09	60.0	COG3608@1|root,COG3608@2|Bacteria,1G167@1117|Cyanobacteria,1H7T8@1150|Oscillatoriales	1117|Cyanobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
WLSH3_k127_9345099_0	1094980.Mpsy_2769	3.474e-96	325.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
WLSH3_k127_9345099_1	399550.Smar_1443	4.92e-75	263.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
WLSH3_k127_9345099_2	1175306.GWL_09630	1.74e-23	103.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,472U1@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
WLSH3_k127_9395471_2	1041930.Mtc_0820	3.007e-14	74.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2N9FP@224756|Methanomicrobia	224756|Methanomicrobia	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
WLSH3_k127_9395471_1	1470593.BW43_01648	8.279e-16	88.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,1S69E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	transporter	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_9395471_0	1041607.K0KNP6	5.068e-20	98.0	COG2012@1|root,KOG3218@2759|Eukaryota,398T1@33154|Opisthokonta,3NVDE@4751|Fungi,3QKQN@4890|Ascomycota,3RRQD@4891|Saccharomycetes	4751|Fungi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity)	RPB5	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005730,GO:0005736,GO:0006139,GO:0006351,GO:0006360,GO:0006366,GO:0006383,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009304,GO:0009987,GO:0010467,GO:0016070,GO:0016591,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042797,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044452,GO:0044464,GO:0046483,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:0098781,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	-	ko:K03013	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb5_C,RNA_pol_Rpb5_N
WLSH3_k127_9401842_1	573064.Mefer_0206	2.398e-121	402.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
WLSH3_k127_9401842_10	272844.PAB1522.1n	2.365e-10	64.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZXP@28890|Euryarchaeota,244NJ@183968|Thermococci	183968|Thermococci	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
WLSH3_k127_9401842_4	591019.Shell_1444	1.717e-75	260.0	COG0090@1|root,arCOG04067@2157|Archaea,2XPW8@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WLSH3_k127_9401842_9	1183377.Py04_1705	1.837e-20	96.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
WLSH3_k127_9401842_3	877455.Metbo_0775	2.435e-80	278.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
WLSH3_k127_9401842_2	572546.Arcpr_1361	2.386e-102	345.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
WLSH3_k127_9401842_7	1041930.Mtc_1321	2.488e-33	139.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
WLSH3_k127_9401842_8	399549.Msed_0121	4.835e-23	104.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
WLSH3_k127_9401842_0	439481.Aboo_1085	2.266e-157	514.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,3F2HC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Radical_SAM C-terminal domain	elp3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
WLSH3_k127_9401842_11	273063.STK_12645	7.791e-10	61.0	COG4919@1|root,arCOG04293@2157|Archaea	2157|Archaea	J	ribosomal protein S30	rps30e	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
WLSH3_k127_9401842_6	673860.AciM339_0239	2.576e-61	220.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,3F2KR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
WLSH3_k127_9401842_5	272844.PAB1936	3.902e-68	238.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2430R@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
WLSH3_k127_9457219_1	748449.Halha_1040	0.0008269	51.0	COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,249P4@186801|Clostridia,3WBFU@53433|Halanaerobiales	186801|Clostridia	E	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
WLSH3_k127_9457219_0	1365176.N186_05835	3.79e-51	188.0	COG1313@1|root,arCOG00934@2157|Archaea,2XPK3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_9458368_0	406327.Mevan_0385	5.636e-98	334.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,23QBT@183939|Methanococci	183939|Methanococci	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
WLSH3_k127_948561_1	485913.Krac_5774	3.247e-51	193.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
WLSH3_k127_948561_0	70601.3256635	1.089e-74	269.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_948561_2	98439.AJLL01000098_gene1943	5.917e-06	57.0	COG0312@1|root,COG0312@2|Bacteria,1G0F3@1117|Cyanobacteria,1JHAA@1189|Stigonemataceae	1117|Cyanobacteria	S	Putative modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_948613_3	1167006.UWK_02352	3.645e-66	237.0	COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,42P53@68525|delta/epsilon subdivisions,2WJ2U@28221|Deltaproteobacteria,2MIZU@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
WLSH3_k127_948613_0	438753.AZC_0301	1.583e-243	768.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,3EYAB@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
WLSH3_k127_948613_2	1304874.JAFY01000002_gene895	5.631e-111	370.0	COG0624@1|root,COG0624@2|Bacteria,3TBDJ@508458|Synergistetes	508458|Synergistetes	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_948613_1	1365176.N186_07015	1.306e-198	633.0	COG0504@1|root,arCOG00063@2157|Archaea,2XPKS@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
WLSH3_k127_9552263_1	1227484.C471_12936	9.275e-15	83.0	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,23WZT@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Abi
WLSH3_k127_9552263_0	926569.ANT_03680	5.103e-25	114.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_9558300_0	391009.Tmel_0322	3.581e-18	99.0	COG0840@1|root,COG0840@2|Bacteria,2GC78@200918|Thermotogae	200918|Thermotogae	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
WLSH3_k127_956351_0	410358.Mlab_1274	7.194e-13	79.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_956351_1	368408.Tpen_0818	1.314e-06	60.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_956351_2	472175.EL18_00166	0.0003437	49.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,43HDQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
WLSH3_k127_9563805_3	272630.MexAM1_META1p1269	1.473e-14	82.0	COG4249@1|root,COG4249@2|Bacteria,1MXS7@1224|Proteobacteria,2U4FS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
WLSH3_k127_9563805_5	545693.BMQ_3906	0.0005755	51.0	COG1522@1|root,COG1522@2|Bacteria,1V3KB@1239|Firmicutes,4HH7P@91061|Bacilli,1ZH2F@1386|Bacillus	91061|Bacilli	K	helix_turn_helix ASNC type	lrpC	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_9563805_4	368407.Memar_0501	0.0001195	52.0	COG1585@1|root,arCOG01912@2157|Archaea,2Y07X@28890|Euryarchaeota	28890|Euryarchaeota	O	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
WLSH3_k127_9563805_2	439481.Aboo_0463	2.147e-61	226.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y726@28890|Euryarchaeota,3F38D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K19576	-	-	-	-	ko00000,ko02000	2.A.1.2.10	-	-	MFS_1
WLSH3_k127_9563805_0	644966.Tmar_0462	1.195e-91	325.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3WDH0@538999|Clostridiales incertae sedis	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
WLSH3_k127_9563805_1	771875.Ferpe_0832	2.094e-77	275.0	COG2211@1|root,COG2211@2|Bacteria,2GCM3@200918|Thermotogae	200918|Thermotogae	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_9573752_2	1457250.BBMO01000001_gene1581	4.217e-05	53.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
WLSH3_k127_9573752_0	1047013.AQSP01000092_gene313	3.541e-32	128.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_9610238_0	1267535.KB906767_gene1202	5.717e-47	179.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF2505
WLSH3_k127_9610238_1	1089548.KI783301_gene1429	3.574e-23	110.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli,3WFFR@539002|Bacillales incertae sedis	91061|Bacilli	P	Arsenical pump membrane protein	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
WLSH3_k127_9636069_1	293826.Amet_1912	6.555e-119	390.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,24BVW@186801|Clostridia,36GH5@31979|Clostridiaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
WLSH3_k127_9636069_0	529709.PYCH_06050	7.282e-124	409.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,242R1@183968|Thermococci	183968|Thermococci	V	K homology RNA-binding domain	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
WLSH3_k127_9636069_2	877455.Metbo_0616	1.117e-19	98.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,23P3J@183925|Methanobacteria	183925|Methanobacteria	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
WLSH3_k127_9636069_3	634498.mru_1039	3.133e-05	51.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23P79@183925|Methanobacteria	183925|Methanobacteria	C	hydrogenase maturation protease HycI	hycI	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
WLSH3_k127_9643698_2	272844.PAB1107	8.845e-14	77.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVWR@28890|Euryarchaeota,242RB@183968|Thermococci	183968|Thermococci	P	Bacterial Na+/H+ antiporter B (NhaB)	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
WLSH3_k127_9643698_1	42256.RradSPS_3002	1.308e-37	145.0	COG0394@1|root,COG0394@2|Bacteria,2HEP3@201174|Actinobacteria,4CTHA@84995|Rubrobacteria	84995|Rubrobacteria	T	low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
WLSH3_k127_9643698_0	1229909.NSED_07320	3.179e-62	233.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
WLSH3_k127_9653034_3	1463855.JOHV01000007_gene5085	2.216e-14	82.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria	201174|Actinobacteria	P	Arsenical pump membrane protein	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
WLSH3_k127_9653034_0	309807.SRU_0049	3.066e-90	308.0	COG2309@1|root,COG2309@2|Bacteria,4NRU3@976|Bacteroidetes	976|Bacteroidetes	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
WLSH3_k127_9653034_1	1300350.DSW25_10350	2.468e-26	117.0	COG4912@1|root,COG4912@2|Bacteria,1NKDG@1224|Proteobacteria,2TU19@28211|Alphaproteobacteria,3ZV9X@60136|Sulfitobacter	28211|Alphaproteobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
WLSH3_k127_9653034_2	296587.XP_002499612.1	7.11e-19	100.0	COG1055@1|root,KOG2639@2759|Eukaryota,37JD9@33090|Viridiplantae,34NC8@3041|Chlorophyta	3041|Chlorophyta	P	Arsenical pump membrane protein	ARSB	-	-	-	-	-	-	-	-	-	-	-	ArsB,CitMHS
WLSH3_k127_9663401_1	290318.Cvib_1206	6.836e-91	312.0	COG0277@1|root,COG0277@2|Bacteria,1FDCI@1090|Chlorobi	1090|Chlorobi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_9663401_0	368407.Memar_2034	3.356e-116	391.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9663401_2	1183377.Py04_1132	1.346e-72	257.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota,242VZ@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
WLSH3_k127_9663401_3	1384484.AEQU_0877	2.129e-39	154.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4CV8F@84998|Coriobacteriia	84998|Coriobacteriia	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
WLSH3_k127_9663401_4	237368.SCABRO_02489	2.061e-33	132.0	COG0543@1|root,COG0543@2|Bacteria,2IYBB@203682|Planctomycetes	203682|Planctomycetes	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
WLSH3_k127_9684112_3	456442.Mboo_2054	2.326e-06	51.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2NAI4@224756|Methanomicrobia	224756|Methanomicrobia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,PAPS_reduct
WLSH3_k127_9684112_0	426368.MmarC7_1436	2.623e-70	251.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23QC5@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
WLSH3_k127_9684112_2	304371.MCP_1552	1.123e-35	147.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,2N98G@224756|Methanomicrobia	224756|Methanomicrobia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
WLSH3_k127_9684112_1	1131814.JAFO01000001_gene4326	2.673e-50	187.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,3F0J3@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
WLSH3_k127_9691432_0	1304865.JAGF01000001_gene2184	3.03e-71	252.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_9691432_1	1109445.AGSX01000141_gene874	0.0003987	44.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1Z4DS@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_9714328_0	399550.Smar_1449	1.704e-51	186.0	COG0674@1|root,arCOG01608@2157|Archaea,2XPUZ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_9714328_2	666510.ASAC_0097	3.91e-24	105.0	COG1144@1|root,arCOG01604@2157|Archaea,2XQU1@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
WLSH3_k127_9714328_1	515635.Dtur_0260	6.197e-45	171.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
WLSH3_k127_9725053_2	366602.Caul_4633	8.834e-07	50.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,2KF7K@204458|Caulobacterales	204458|Caulobacterales	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
WLSH3_k127_9725053_0	224325.AF_1772	6.154e-64	229.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_9725053_1	326427.Cagg_1682	2.387e-19	92.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_23570	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_34
WLSH3_k127_9729413_1	118166.JH976538_gene5395	1.956e-14	74.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1G1DF@1117|Cyanobacteria,1H8EP@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
WLSH3_k127_9729413_0	555079.Toce_1342	3.388e-173	566.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
WLSH3_k127_9756194_1	765911.Thivi_3054	1.142e-06	56.0	COG1198@1|root,COG1198@2|Bacteria,1QU4F@1224|Proteobacteria,1T59I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9756194_0	439235.Dalk_4041	3.587e-89	306.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2WMZ9@28221|Deltaproteobacteria,2MPEE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	pcmI	-	1.17.99.1	ko:K05797	ko00623,ko01100,ko01120,map00623,map01100,map01120	-	R02675,R11194	RC00769	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_9764152_0	697329.Rumal_1463	1.081e-57	231.0	COG1372@1|root,COG3209@1|root,COG1372@2|Bacteria,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,3WHQ2@541000|Ruminococcaceae	186801|Clostridia	M	RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PT-HINT,RHS_repeat
WLSH3_k127_9822250_0	304371.MCP_1858	1.751e-13	81.0	COG0642@1|root,COG2202@1|root,arCOG02352@1|root,arCOG02352@2157|Archaea,arCOG06192@2157|Archaea,arCOG06515@2157|Archaea,2Y7RQ@28890|Euryarchaeota,2NAGK@224756|Methanomicrobia	224756|Methanomicrobia	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS_3,PAS_9,Response_reg
WLSH3_k127_9847158_0	246437.XP_006149194.1	1.742e-09	62.0	COG1233@1|root,KOG4254@2759|Eukaryota,38GIP@33154|Opisthokonta,3BGWD@33208|Metazoa,3CXHQ@33213|Bilateria,4899J@7711|Chordata,492H2@7742|Vertebrata,3J8KJ@40674|Mammalia,35BA5@314146|Euarchontoglires	33208|Metazoa	H	all-trans-retinol 13,14-reductase activity	RETSAT	GO:0001523,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005640,GO:0005737,GO:0005783,GO:0005789,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0009987,GO:0010817,GO:0012505,GO:0016020,GO:0016101,GO:0016491,GO:0016627,GO:0019867,GO:0031090,GO:0031965,GO:0031967,GO:0031968,GO:0031975,GO:0031984,GO:0034308,GO:0034754,GO:0042175,GO:0042445,GO:0042572,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0051786,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0098588,GO:0098805,GO:0098827,GO:1901615	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
WLSH3_k127_9847244_0	572478.Vdis_0713	4.184e-137	455.0	COG0495@1|root,arCOG00809@2157|Archaea,2XPP2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
WLSH3_k127_9847244_1	673860.AciM339_1034	3.681e-134	438.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,3F2EY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
WLSH3_k127_9865464_0	439481.Aboo_1150	0.0008164	48.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,3F2K5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
WLSH3_k127_9887191_1	386456.JQKN01000002_gene2741	5.941e-41	160.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
WLSH3_k127_9887191_2	1131266.ARWQ01000010_gene51	2.168e-10	68.0	COG1439@1|root,arCOG00721@2157|Archaea,41SPQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
WLSH3_k127_9887191_0	304371.MCP_0732	2.128e-50	183.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
WLSH3_k127_9914227_1	760568.Desku_2760	1.319e-27	115.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,261PE@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
WLSH3_k127_9914227_0	186497.PF2015	3.76e-172	566.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
WLSH3_k127_9914227_3	626369.HMPREF0446_01416	0.0006113	50.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,4HNI5@91061|Bacilli	91061|Bacilli	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_9914227_2	456442.Mboo_1535	1.855e-07	57.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
WLSH3_k127_9972712_0	1122138.AQUZ01000036_gene5471	3.118e-41	165.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4DU0R@85009|Propionibacteriales	201174|Actinobacteria	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_9972712_1	55952.BU52_22815	8.457e-41	173.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
WLSH3_k127_999420_0	439481.Aboo_0134	7.061e-06	56.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
## 2024 queries scanned
## Total time (seconds): 11.567322254180908
## Rate: 174.98 q/s