## Tue Dec 16 23:38:25 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/WLSH3_bin.43.fa -m mmseqs --itype genome -o WLSH3_bin.43 --output_dir /data/result/bins/wyx/egg/WLSH3_bin.43 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
WLSH3_k127_10001056_1	1047013.AQSP01000114_gene686	1.405e-15	83.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_10001056_0	1125863.JAFN01000001_gene2593	1.123e-98	337.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_10001056_2	1234595.C725_2876	0.0003189	45.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2TQZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_10027366_1	877455.Metbo_2336	5.098e-90	308.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_10027366_0	589924.Ferp_1389	3.659e-103	344.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_10027366_2	368408.Tpen_1831	2.876e-63	234.0	COG2211@1|root,arCOG00146@2157|Archaea,2XSCD@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
WLSH3_k127_10027366_3	261292.Nit79A3_1514	5.713e-54	213.0	COG0383@1|root,COG0383@2|Bacteria,1R3Q8@1224|Proteobacteria	1224|Proteobacteria	G	Alpha-Mannosidase	mngB	GO:0003674,GO:0003824,GO:0004553,GO:0004559,GO:0005975,GO:0005996,GO:0006013,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015923,GO:0016787,GO:0016798,GO:0019318,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0071704,GO:1901135,GO:1901564	3.2.1.170,3.2.1.24	ko:K01191,ko:K15524	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	iEcolC_1368.EcolC_2924,iSF_1195.SF0565,iSFxv_1172.SFxv_0623,iS_1188.S0578	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
WLSH3_k127_10070641_0	1382306.JNIM01000001_gene3950	6.367e-71	253.0	COG0383@1|root,COG0383@2|Bacteria,2G5U7@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
WLSH3_k127_10070641_4	383372.Rcas_3603	4.764e-05	52.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
WLSH3_k127_10070641_2	368407.Memar_2490	3.484e-19	94.0	COG1321@1|root,arCOG02100@2157|Archaea,2XX2E@28890|Euryarchaeota	28890|Euryarchaeota	K	COG1321 Mn-dependent transcriptional regulator	idr	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
WLSH3_k127_10070641_3	243232.MJ_0565	1.206e-07	59.0	arCOG04938@1|root,arCOG04938@2157|Archaea,2XZYR@28890|Euryarchaeota,23RR4@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10070641_1	521011.Mpal_2325	3.085e-33	131.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N92S@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	iAF692.Mbar_A1452	FeoB_C,FeoB_N,Gate
WLSH3_k127_10111270_3	180332.JTGN01000001_gene5148	1.587e-35	141.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
WLSH3_k127_10111270_0	56780.SYN_02526	5.95e-108	361.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,42SXH@68525|delta/epsilon subdivisions,2WP5D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
WLSH3_k127_10111270_1	1227457.C451_17235	4.703e-103	363.0	COG0318@1|root,arCOG00856@2157|Archaea,2Y2G5@28890|Euryarchaeota,23Z07@183963|Halobacteria	183963|Halobacteria	I	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_10111270_2	589924.Ferp_2103	1.093e-38	166.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,245XW@183980|Archaeoglobi	183980|Archaeoglobi	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_10184062_2	391937.NA2_19428	1.205e-20	103.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,2TRPY@28211|Alphaproteobacteria,43I8M@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
WLSH3_k127_10184062_0	321327.CYA_2061	1.557e-103	354.0	COG0312@1|root,COG0312@2|Bacteria,1G0BB@1117|Cyanobacteria,1GYUI@1129|Synechococcus	1117|Cyanobacteria	S	Putative modulator of DNA gyrase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_10184062_1	1459636.NTE_02580	1.068e-81	288.0	COG0312@1|root,arCOG00322@2157|Archaea,41T72@651137|Thaumarchaeota	651137|Thaumarchaeota	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_1038387_4	439481.Aboo_1131	6.764e-86	291.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2FS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
WLSH3_k127_1038387_18	1229909.NSED_05205	1.779e-16	88.0	COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	-	ko:K03014	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
WLSH3_k127_1038387_17	317025.Tcr_1067	1.026e-17	96.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,460BI@72273|Thiotrichales	72273|Thiotrichales	S	MgtC family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
WLSH3_k127_1038387_3	479434.Sthe_0476	1.001e-86	303.0	COG0124@1|root,COG0124@2|Bacteria,2G64E@200795|Chloroflexi,27XH4@189775|Thermomicrobia	189775|Thermomicrobia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
WLSH3_k127_1038387_9	694429.Pyrfu_0913	5.822e-70	247.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
WLSH3_k127_1038387_12	1174504.AJTN02000211_gene3618	1.347e-37	157.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	blt	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	iYO844.BSU26590	MFS_1,MFS_1_like,MFS_2,Sugar_tr
WLSH3_k127_1038387_14	604354.TSIB_1918	6.746e-30	124.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,242MM@183968|Thermococci	183968|Thermococci	K	regulator of amino acid metabolism	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	ACT
WLSH3_k127_1038387_20	1211817.CCAT010000045_gene3063	6.502e-12	73.0	COG0454@1|root,COG0456@2|Bacteria,1VAZN@1239|Firmicutes,25EWF@186801|Clostridia,36J7D@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_1038387_23	439235.Dalk_0162	7.858e-06	57.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
WLSH3_k127_1038387_5	439235.Dalk_0163	1.165e-83	289.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_1038387_0	439235.Dalk_0164	3.848e-208	674.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
WLSH3_k127_1038387_19	243231.GSU1945	3.88e-13	83.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
WLSH3_k127_1038387_13	1230460.C495_13211	8.247e-36	148.0	COG1992@1|root,arCOG00021@2157|Archaea,2XT4Y@28890|Euryarchaeota,23RXW@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
WLSH3_k127_1038387_11	391623.TERMP_01742	1.179e-60	224.0	COG4143@1|root,arCOG00226@2157|Archaea,2XT44@28890|Euryarchaeota,24311@183968|Thermococci	183968|Thermococci	H	ABC-type thiamine transport system, periplasmic component	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
WLSH3_k127_1038387_8	1499967.BAYZ01000158_gene435	4.034e-75	273.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	thiP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	iAPECO1_1312.APECO1_1915,iECIAI1_1343.ECIAI1_0067,iECO103_1326.ECO103_0068,iECO111_1330.ECO111_0069,iECO26_1355.ECO26_0069,iECOK1_1307.ECOK1_0068,iECS88_1305.ECS88_0072,iECSE_1348.ECSE_0067,iECUMN_1333.ECUMN_0068,iPC815.YPO0521,iSF_1195.SF0062,iSFxv_1172.SFxv_0064,iS_1188.S0064,iUMN146_1321.UM146_23130,iUTI89_1310.UTI89_C0075	BPD_transp_1
WLSH3_k127_1038387_6	195522.BD01_2142	6.814e-82	284.0	COG3839@1|root,arCOG00177@2157|Archaea,2XTU1@28890|Euryarchaeota,24302@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02062	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	ABC_tran
WLSH3_k127_1038387_22	1283300.ATXB01000001_gene2190	1.566e-09	64.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria,1XF8R@135618|Methylococcales	135618|Methylococcales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_1038387_7	1448389.BAVQ01000070_gene2284	1.923e-76	269.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
WLSH3_k127_1038387_10	1042156.CXIVA_16150	1.938e-68	252.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	BBE,FAD_binding_4
WLSH3_k127_1038387_1	903818.KI912269_gene284	1.074e-105	358.0	COG0247@1|root,COG0247@2|Bacteria,3Y3RK@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
WLSH3_k127_1038387_2	903818.KI912269_gene283	7.206e-103	351.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_1038387_24	1157638.KB892174_gene325	3.428e-05	49.0	COG2440@1|root,COG2440@2|Bacteria,2IQVY@201174|Actinobacteria	201174|Actinobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO,Fer4_9
WLSH3_k127_1038387_15	481448.Minf_0475	1.854e-29	133.0	COG0644@1|root,COG0644@2|Bacteria,46WP0@74201|Verrucomicrobia,37G3V@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	FAD binding domain	-	-	1.5.5.1	ko:K00311,ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
WLSH3_k127_1038387_21	312284.A20C1_02509	3.943e-10	68.0	COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	padR	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_1040994_2	439481.Aboo_0134	8.557e-07	62.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_1040994_3	439481.Aboo_1209	0.0005229	53.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_1040994_1	439481.Aboo_0134	3.83e-07	63.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_1040994_0	521011.Mpal_0672	1.033e-45	176.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
WLSH3_k127_10411976_1	868131.MSWAN_2385	2.06e-167	538.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_10411976_4	386456.JQKN01000011_gene731	5.27e-65	230.0	COG0479@1|root,arCOG00962@2157|Archaea,2XSXW@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
WLSH3_k127_10411976_5	880073.Calab_2008	3.705e-64	232.0	COG2189@1|root,COG2189@2|Bacteria,2NP0F@2323|unclassified Bacteria	2|Bacteria	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
WLSH3_k127_10411976_14	444157.Tneu_0050	1.23e-17	86.0	COG1383@1|root,arCOG01885@2157|Archaea,2XRGM@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
WLSH3_k127_10411976_2	368408.Tpen_0750	4.312e-167	544.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
WLSH3_k127_10411976_10	671143.DAMO_2655	8.331e-26	113.0	COG0720@1|root,COG0720@2|Bacteria,2NR6T@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
WLSH3_k127_10411976_6	70601.3258219	1.078e-61	222.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,243S1@183968|Thermococci	183968|Thermococci	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
WLSH3_k127_10411976_8	660470.Theba_2261	2.239e-36	141.0	2DH26@1|root,2ZY4Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
WLSH3_k127_10411976_18	1250005.PHEL85_2242	2.479e-06	60.0	COG2133@1|root,COG2706@1|root,COG3210@1|root,COG3291@1|root,COG5492@1|root,COG2133@2|Bacteria,COG2706@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG5492@2|Bacteria,4P5ZZ@976|Bacteroidetes,1IAGP@117743|Flavobacteriia,3VW03@52959|Polaribacter	976|Bacteroidetes	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10411976_13	1457250.BBMO01000001_gene1619	1.288e-18	99.0	COG0642@1|root,arCOG06192@2157|Archaea,2Y7XK@28890|Euryarchaeota	28890|Euryarchaeota	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HTH_10,PAS_4,PAS_9,Response_reg
WLSH3_k127_10411976_7	304371.MCP_2060	9.014e-58	214.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10411976_0	1094980.Mpsy_1642	1.696e-235	746.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,2N99D@224756|Methanomicrobia	224756|Methanomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
WLSH3_k127_10411976_11	237368.SCABRO_02097	1.218e-24	108.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx
WLSH3_k127_10411976_16	479433.Caci_4861	1.202e-09	66.0	COG0406@1|root,COG0406@2|Bacteria,2IRT2@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WLSH3_k127_10411976_9	883078.HMPREF9695_04918	2.344e-26	115.0	COG1225@1|root,COG1225@2|Bacteria,1RBZX@1224|Proteobacteria,2U62X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
WLSH3_k127_10411976_3	1047013.AQSP01000067_gene2204	2.406e-96	327.0	COG0436@1|root,COG0436@2|Bacteria,2NR19@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_10411976_19	1304872.JAGC01000009_gene1335	4.661e-06	55.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria,2M8Q5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
WLSH3_k127_10411976_12	1033806.HTIA_1955	1.476e-19	92.0	arCOG14997@1|root,arCOG14997@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10411976_17	5850.PKH_051570	1.843e-07	61.0	COG0468@1|root,KOG1434@2759|Eukaryota,3Y9X6@5794|Apicomplexa,3KBT3@422676|Aconoidasida,3YXYA@5819|Haemosporida	422676|Aconoidasida	L	Meiotic recombination protein	-	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000722,GO:0000723,GO:0000724,GO:0000725,GO:0000730,GO:0000781,GO:0000784,GO:0000785,GO:0000790,GO:0000793,GO:0000794,GO:0000795,GO:0000800,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006281,GO:0006282,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008022,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009719,GO:0009893,GO:0009987,GO:0010033,GO:0010212,GO:0010243,GO:0010564,GO:0010569,GO:0010604,GO:0010833,GO:0010948,GO:0014070,GO:0016043,GO:0016462,GO:0016604,GO:0016605,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0022402,GO:0022414,GO:0022607,GO:0030554,GO:0031297,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032200,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0035639,GO:0035690,GO:0035825,GO:0035861,GO:0036094,GO:0036297,GO:0042148,GO:0042221,GO:0042493,GO:0042592,GO:0042623,GO:0042802,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043279,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0045003,GO:0045005,GO:0045786,GO:0045935,GO:0046483,GO:0048285,GO:0048471,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051105,GO:0051106,GO:0051171,GO:0051173,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051716,GO:0051726,GO:0060249,GO:0060255,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0070013,GO:0070182,GO:0070192,GO:0070316,GO:0070317,GO:0070887,GO:0071103,GO:0071214,GO:0071310,GO:0071312,GO:0071407,GO:0071417,GO:0071478,GO:0071479,GO:0071495,GO:0071704,GO:0071824,GO:0071840,GO:0072757,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0090734,GO:0090735,GO:0097159,GO:0097305,GO:0097306,GO:0097327,GO:0097367,GO:0098687,GO:0099086,GO:0104004,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901563,GO:1901576,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903046,GO:2000779,GO:2001020	-	ko:K10872	ko04113,map04113	-	-	-	ko00000,ko00001,ko03400	-	-	-	Rad51
WLSH3_k127_10424518_2	1220534.B655_1002	1.381e-08	68.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
WLSH3_k127_10424518_1	926554.KI912633_gene3792	6.017e-09	69.0	COG3325@1|root,COG4932@1|root,COG3325@2|Bacteria,COG4932@2|Bacteria,1WISS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
WLSH3_k127_10424518_3	113395.AXAI01000001_gene2860	3.141e-08	64.0	COG2345@1|root,COG2345@2|Bacteria,1RIDX@1224|Proteobacteria,2U9M4@28211|Alphaproteobacteria,3JYN3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_10424518_0	443254.Marpi_0537	3.197e-75	275.0	COG1164@1|root,COG1164@2|Bacteria,2GCJ4@200918|Thermotogae	200918|Thermotogae	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
WLSH3_k127_10424518_4	443218.AS9A_0986	5.819e-07	55.0	COG1545@1|root,COG1545@2|Bacteria,2GJHW@201174|Actinobacteria,2342N@1762|Mycobacteriaceae	201174|Actinobacteria	S	Nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_10513457_9	4897.EEB09438	0.0008502	49.0	COG2227@1|root,KOG1270@2759|Eukaryota,39T8B@33154|Opisthokonta,3NZTD@4751|Fungi,3QNCR@4890|Ascomycota,3MCJ1@451866|Taphrinomycotina	4751|Fungi	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	COQ3	GO:0003674,GO:0003824,GO:0004395,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008757,GO:0009058,GO:0009108,GO:0009987,GO:0010420,GO:0016020,GO:0016740,GO:0016741,GO:0019866,GO:0019898,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032259,GO:0042180,GO:0042181,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0061542,GO:0061543,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.114,2.1.1.222,2.1.1.64	ko:K00568,ko:K00591	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R02175,R04711,R04988,R05614,R07235,R08769,R08771,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
WLSH3_k127_10513457_6	1423321.AS29_14965	2.626e-19	99.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,4HCYJ@91061|Bacilli,1ZAPI@1386|Bacillus	91061|Bacilli	S	membrane transporter protein	yunE	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
WLSH3_k127_10513457_1	35841.BT1A1_1716	3.237e-61	219.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,1ZB50@1386|Bacillus	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
WLSH3_k127_10513457_4	1385513.N780_05520	4.58e-29	126.0	2DNQ8@1|root,32YJ3@2|Bacteria,1VXNK@1239|Firmicutes,4HXD0@91061|Bacilli,2YAZG@289201|Pontibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10513457_2	926549.KI421517_gene821	4.462e-61	223.0	COG0384@1|root,COG0384@2|Bacteria,4NMWV@976|Bacteroidetes,47PEQ@768503|Cytophagia	976|Bacteroidetes	S	phenazine biosynthesis protein PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
WLSH3_k127_10513457_3	43151.ADAC004327-PA	9.296e-31	128.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa,3CXE2@33213|Bilateria,41YZI@6656|Arthropoda,3SJKJ@50557|Insecta,44YPV@7147|Diptera,45D4S@7148|Nematocera	33208|Metazoa	U	Rab subfamily of small GTPases	RAB18	GO:0000166,GO:0001654,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0006810,GO:0006913,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034389,GO:0035556,GO:0036094,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0097159,GO:0097367,GO:0098827,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
WLSH3_k127_10513457_7	754027.HMPREF9554_02651	9.697e-16	87.0	2F5DW@1|root,33XZS@2|Bacteria,2J9XX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10513457_5	292459.STH1963	5.89e-22	96.0	COG1247@1|root,COG1247@2|Bacteria,1UIRW@1239|Firmicutes,25EQT@186801|Clostridia	186801|Clostridia	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_10513457_8	292459.STH1963	8.78e-08	56.0	COG1247@1|root,COG1247@2|Bacteria,1UIRW@1239|Firmicutes,25EQT@186801|Clostridia	186801|Clostridia	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_10513457_0	565033.GACE_2079	1.593e-215	697.0	arCOG02763@1|root,arCOG02763@2157|Archaea,2Y8CF@28890|Euryarchaeota,247IC@183980|Archaeoglobi	183980|Archaeoglobi	P	Heavy-metal-associated domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH3_k127_10541816_2	1123325.JHUV01000010_gene1206	1.018e-11	74.0	COG3233@1|root,COG3233@2|Bacteria,2G517@200783|Aquificae	200783|Aquificae	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
WLSH3_k127_10541816_1	523850.TON_0185	5.627e-12	69.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
WLSH3_k127_10541816_0	1041930.Mtc_0093	1.53e-91	314.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
WLSH3_k127_10556580_1	858215.Thexy_2211	3.415e-211	681.0	COG4354@1|root,COG4354@2|Bacteria,1TR78@1239|Firmicutes,25K1B@186801|Clostridia,42ITY@68295|Thermoanaerobacterales	186801|Clostridia	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
WLSH3_k127_10556580_10	309803.CTN_0664	1.386e-34	152.0	COG0747@1|root,COG0747@2|Bacteria,2GC8R@200918|Thermotogae	200918|Thermotogae	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iLJ478.TM0031	SBP_bac_5
WLSH3_k127_10556580_5	272844.PAB1347	1.267e-80	276.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y3A0@28890|Euryarchaeota,242W7@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_10556580_6	1198449.ACAM_0992	2.376e-78	273.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_10556580_7	381764.Fnod_1555	3.425e-65	234.0	COG1173@1|root,COG1173@2|Bacteria,2GCEA@200918|Thermotogae	200918|Thermotogae	P	PFAM Binding-protein-dependent transport	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_10556580_8	543632.JOJL01000039_gene1596	6.408e-65	235.0	COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4DH1C@85008|Micromonosporales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_10556580_0	1291050.JAGE01000001_gene2731	1.654e-262	831.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3WGK9@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyltransferase family 36	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
WLSH3_k127_10556580_11	374847.Kcr_1553	1.612e-19	96.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_10556580_4	565033.GACE_0076	6.413e-84	287.0	COG1606@1|root,arCOG00043@2157|Archaea,2XV2X@28890|Euryarchaeota,245RE@183980|Archaeoglobi	183980|Archaeoglobi	S	Queuosine biosynthesis protein QueC	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
WLSH3_k127_10556580_2	374847.Kcr_0480	6.201e-119	394.0	COG1641@1|root,arCOG02701@2157|Archaea	2157|Archaea	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
WLSH3_k127_10556580_3	374847.Kcr_0479	2.608e-98	328.0	COG1691@1|root,arCOG02465@2157|Archaea	2157|Archaea	S	1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
WLSH3_k127_10556580_9	273075.Ta0351	5.074e-64	233.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
WLSH3_k127_10556580_12	589924.Ferp_1943	5.128e-06	56.0	COG1545@1|root,arCOG01283@2157|Archaea,2XX0U@28890|Euryarchaeota,24665@183980|Archaeoglobi	183980|Archaeoglobi	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_10602976_5	1365176.N186_01480	3.96e-119	397.0	COG0148@1|root,arCOG01169@2157|Archaea,2XPZ6@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
WLSH3_k127_10602976_7	647113.Metok_0267	8.788e-111	371.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,23PZZ@183939|Methanococci	183939|Methanococci	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
WLSH3_k127_10602976_10	342949.PNA2_1018	3.196e-93	322.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUJT@28890|Euryarchaeota,245AW@183968|Thermococci	183968|Thermococci	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
WLSH3_k127_10602976_8	439235.Dalk_0051	4.959e-98	327.0	COG1145@1|root,COG1145@2|Bacteria	439235.Dalk_0051|-	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10602976_15	646529.Desaci_2459	1.636e-63	222.0	COG0242@1|root,COG0242@2|Bacteria,1V41Q@1239|Firmicutes,24I9S@186801|Clostridia	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
WLSH3_k127_10602976_27	1408422.JHYF01000019_gene1405	3.812e-16	94.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,36DY1@31979|Clostridiaceae	186801|Clostridia	S	UPF0182 protein	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
WLSH3_k127_10602976_14	485916.Dtox_2855	1.684e-70	250.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,261N7@186807|Peptococcaceae	186801|Clostridia	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
WLSH3_k127_10602976_33	1236542.BALM01000029_gene2255	1.951e-09	62.0	COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,1SCBH@1236|Gammaproteobacteria,2QCJG@267890|Shewanellaceae	1236|Gammaproteobacteria	L	PFAM Excinuclease ABC, C subunit domain protein	yhbQ	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
WLSH3_k127_10602976_4	1382304.JNIL01000001_gene1376	4.497e-126	420.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4H9W6@91061|Bacilli	91061|Bacilli	G	Belongs to the FGGY kinase family	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_10602976_20	304371.MCP_0283	5.846e-41	168.0	COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota,2N9Q8@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
WLSH3_k127_10602976_26	1041930.Mtc_2336	4.018e-18	96.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
WLSH3_k127_10602976_31	272557.APE_2326.1	2.237e-11	69.0	COG0636@1|root,arCOG02455@2157|Archaea,2XR87@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase proteolipid subunit family	atpP	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
WLSH3_k127_10602976_29	69014.TK1599	1.657e-15	84.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,243A6@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
WLSH3_k127_10602976_21	523845.AQXV01000049_gene944	3.245e-40	171.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,23Q54@183939|Methanococci	183939|Methanococci	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
WLSH3_k127_10602976_18	415426.Hbut_1352	1.078e-53	199.0	COG2519@1|root,arCOG00978@2157|Archaea,2XPU6@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
WLSH3_k127_10602976_19	1094980.Mpsy_1920	1.391e-47	194.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota,2N9G3@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
WLSH3_k127_10602976_32	1365176.N186_03930	1.363e-09	64.0	arCOG04275@1|root,arCOG04275@2157|Archaea,2XR2U@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10602976_23	1229909.NSED_07785	1.897e-35	145.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
WLSH3_k127_10602976_3	374847.Kcr_0092	3.348e-130	428.0	COG1167@1|root,arCOG00492@2157|Archaea	2157|Archaea	EK	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
WLSH3_k127_10602976_34	1200792.AKYF01000011_gene3747	3.138e-08	66.0	COG4365@1|root,COG4365@2|Bacteria,1TQ2P@1239|Firmicutes,4HA2Z@91061|Bacilli,26Q9F@186822|Paenibacillaceae	91061|Bacilli	S	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
WLSH3_k127_10602976_11	1124780.ANNU01000017_gene1948	3.848e-84	293.0	COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes,47JT9@768503|Cytophagia	976|Bacteroidetes	M	PFAM Glycosyl transferases group 1	bshA	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_10602976_28	1123070.KB899251_gene773	1.637e-15	85.0	COG2120@1|root,COG2120@2|Bacteria,46XN5@74201|Verrucomicrobia,2IW8H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
WLSH3_k127_10602976_6	342949.PNA2_1735	4.138e-114	384.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,242T7@183968|Thermococci	183968|Thermococci	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WLSH3_k127_10602976_22	400682.PAC_15715228	5.792e-38	149.0	KOG0095@1|root,KOG0095@2759|Eukaryota,38CET@33154|Opisthokonta,3BEQP@33208|Metazoa	33208|Metazoa	U	RAB30, member RAS oncogene family	RAB30	GO:0000139,GO:0001700,GO:0002009,GO:0002165,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005795,GO:0005801,GO:0005802,GO:0006810,GO:0006996,GO:0007030,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007390,GO:0007391,GO:0007444,GO:0007552,GO:0007560,GO:0008150,GO:0008258,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0010256,GO:0012505,GO:0016020,GO:0016043,GO:0016192,GO:0016331,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0023052,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0031985,GO:0032482,GO:0032501,GO:0032502,GO:0035239,GO:0035295,GO:0035556,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045202,GO:0046528,GO:0046529,GO:0048513,GO:0048563,GO:0048569,GO:0048598,GO:0048707,GO:0048729,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0060429,GO:0060562,GO:0065007,GO:0071840,GO:0097708,GO:0098588,GO:0098791	-	ko:K07917	-	-	-	-	ko00000,ko04031	-	-	-	Ras
WLSH3_k127_10602976_9	399550.Smar_1111	6.499e-94	320.0	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
WLSH3_k127_10602976_17	429009.Adeg_0614	8.27e-58	209.0	COG1912@1|root,COG1912@2|Bacteria,1TSR3@1239|Firmicutes,24D3T@186801|Clostridia	186801|Clostridia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
WLSH3_k127_10602976_24	56780.SYN_02919	1.274e-31	130.0	COG0350@1|root,COG0500@1|root,COG0350@2|Bacteria,COG2226@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
WLSH3_k127_10602976_1	215803.DB30_3758	4.768e-184	589.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_10602976_30	592028.GCWU000321_00582	1.919e-13	81.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,4H5JY@909932|Negativicutes	909932|Negativicutes	M	Transporter, small conductance mechanosensitive ion channel MscS family protein	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
WLSH3_k127_10602976_16	1220534.B655_0707	4.4e-60	220.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10602976_13	871963.Desdi_1848	2.951e-71	254.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260YA@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	namA	-	1.3.1.34,1.6.99.1	ko:K00219,ko:K00354	-	-	R00282	RC00001	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
WLSH3_k127_10602976_2	224325.AF_1587	5.187e-160	516.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	28890|Euryarchaeota	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39,5.3.2.5	ko:K01601,ko:K08965	ko00270,ko00630,ko00710,ko01100,ko01120,ko01200,map00270,map00630,map00710,map01100,map01120,map01200	M00034,M00165,M00166,M00532	R00024,R03140,R07393	RC00172,RC00859,RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
WLSH3_k127_10602976_0	509191.AEDB02000035_gene2174	2.595e-184	590.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,3WHBU@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
WLSH3_k127_10602976_12	264732.Moth_1516	8.214e-84	287.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,42FHP@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
WLSH3_k127_10602976_25	555079.Toce_1474	1.532e-21	98.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,42EU0@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Formiminotransferase	ftcD	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
WLSH3_k127_10616294_1	386456.JQKN01000001_gene2171	1.712e-43	171.0	COG0382@1|root,arCOG00476@2157|Archaea,2XVE4@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
WLSH3_k127_10616294_0	269797.Mbar_A1412	1.745e-92	316.0	COG2006@1|root,arCOG02447@2157|Archaea,2Y2ES@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
WLSH3_k127_10616294_2	7230.FBpp0167949	1.614e-40	161.0	COG0639@1|root,KOG0374@2759|Eukaryota,38BV2@33154|Opisthokonta,3B9MQ@33208|Metazoa,3CRW5@33213|Bilateria,41VYT@6656|Arthropoda,3SJ1J@50557|Insecta,44Y2G@7147|Diptera,45P46@7214|Drosophilidae	33208|Metazoa	T	serine threonine-protein phosphatase	-	GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.16	ko:K06269	ko03015,ko04022,ko04024,ko04113,ko04114,ko04218,ko04261,ko04270,ko04390,ko04510,ko04611,ko04720,ko04728,ko04750,ko04810,ko04910,ko04921,ko04931,ko05031,ko05034,ko05168,ko05205,map03015,map04022,map04024,map04113,map04114,map04218,map04261,map04270,map04390,map04510,map04611,map04720,map04728,map04750,map04810,map04910,map04921,map04931,map05031,map05034,map05168,map05205	-	-	-	ko00000,ko00001,ko01000,ko01009,ko03019,ko03021,ko03041	-	-	-	Metallophos,STPPase_N
WLSH3_k127_10616294_3	269797.Mbar_A2411	2.232e-33	135.0	COG1611@1|root,arCOG02431@2157|Archaea,2XXTK@28890|Euryarchaeota,2N9VX@224756|Methanomicrobia	224756|Methanomicrobia	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
WLSH3_k127_10616294_5	1463856.JOHY01000002_gene1120	4.705e-05	51.0	COG1917@1|root,COG1917@2|Bacteria,2IKXC@201174|Actinobacteria	201174|Actinobacteria	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_10616294_4	1382358.JHVN01000009_gene3313	1.605e-06	61.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBK7@91061|Bacilli,21WW3@150247|Anoxybacillus	91061|Bacilli	V	MacB-like periplasmic core domain	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,FtsX,MacB_PCD
WLSH3_k127_10617906_25	318464.IO99_15135	6.785e-05	48.0	COG0500@1|root,COG2226@2|Bacteria,1UFCI@1239|Firmicutes,24K7E@186801|Clostridia	186801|Clostridia	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_10617906_19	449447.MAE_30650	9.45e-09	62.0	COG1669@1|root,COG1669@2|Bacteria,1G8DK@1117|Cyanobacteria	1117|Cyanobacteria	S	DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
WLSH3_k127_10617906_20	457570.Nther_2562	2.066e-08	61.0	COG2445@1|root,COG2445@2|Bacteria,1VF87@1239|Firmicutes,24NYX@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
WLSH3_k127_10617906_24	1227499.C493_12774	6.409e-05	51.0	28HW9@1|root,2N5WN@2157|Archaea,2Y4HG@28890|Euryarchaeota,2407J@183963|Halobacteria	183963|Halobacteria	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
WLSH3_k127_10617906_21	926569.ANT_19730	1.428e-06	55.0	COG1647@1|root,COG1647@2|Bacteria,2G909@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha beta hydrolase fold	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
WLSH3_k127_10617906_5	1340434.AXVA01000014_gene537	6.237e-55	201.0	COG0500@1|root,COG2226@2|Bacteria,1UF5I@1239|Firmicutes,4IJRQ@91061|Bacilli,1ZDZ3@1386|Bacillus	91061|Bacilli	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_10617906_2	604354.TSIB_1725	1.675e-99	332.0	arCOG06481@1|root,arCOG06481@2157|Archaea,2XV5Y@28890|Euryarchaeota,24471@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10617906_14	1280390.CBQR020000097_gene2196	3.591e-14	80.0	2E6H4@1|root,3314B@2|Bacteria,1VW5U@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10617906_9	164757.Mjls_4546	7.142e-22	101.0	COG3467@1|root,COG3467@2|Bacteria,2IK9H@201174|Actinobacteria,239SR@1762|Mycobacteriaceae	201174|Actinobacteria	S	pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
WLSH3_k127_10617906_13	926550.CLDAP_01080	3.034e-14	86.0	COG4412@1|root,COG4412@2|Bacteria,2G622@200795|Chloroflexi	200795|Chloroflexi	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
WLSH3_k127_10617906_11	604354.TSIB_1966	9.979e-15	83.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_10617906_22	420247.Msm_1032	2.364e-06	59.0	COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,23P3M@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
WLSH3_k127_10617906_16	42256.RradSPS_0282	1.958e-12	69.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4CQ7M@84995|Rubrobacteria	84995|Rubrobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_10617906_4	877455.Metbo_1059	1.391e-66	238.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_10617906_17	926569.ANT_00120	1.05e-10	71.0	COG1668@1|root,COG1668@2|Bacteria,2G76A@200795|Chloroflexi	200795|Chloroflexi	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
WLSH3_k127_10617906_23	439481.Aboo_0872	2.773e-06	59.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX3W@28890|Euryarchaeota,3F3AP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	M protein trans-acting positive regulator (MGA) HTH domain	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
WLSH3_k127_10617906_1	351160.RCIX51	3.649e-105	350.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_10617906_10	351160.RCIX50	1.448e-20	101.0	COG1277@1|root,arCOG02436@2157|Archaea	2157|Archaea	S	ABC-type transport system involved in multi-copper enzyme maturation, permease	nosY2	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
WLSH3_k127_10617906_15	1382359.JIAL01000001_gene418	1.337e-13	78.0	COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria,2JJWU@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_10617906_0	1151292.QEW_2968	2.397e-115	382.0	COG3049@1|root,COG3049@2|Bacteria,1UHUX@1239|Firmicutes,25E3I@186801|Clostridia	186801|Clostridia	M	Acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
WLSH3_k127_10617906_12	697282.Mettu_2924	1.19e-14	84.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,1SF4K@1236|Gammaproteobacteria,1XEMW@135618|Methylococcales	135618|Methylococcales	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Ubie_methyltran
WLSH3_k127_10617906_18	1484479.DI14_07190	2.195e-09	64.0	COG0716@1|root,COG0716@2|Bacteria,1VND7@1239|Firmicutes,4I25J@91061|Bacilli	91061|Bacilli	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
WLSH3_k127_10617906_3	485913.Krac_1668	2.052e-88	299.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
WLSH3_k127_10617906_7	1499967.BAYZ01000009_gene5268	1.188e-36	147.0	COG2220@1|root,COG2220@2|Bacteria,2NPQC@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
WLSH3_k127_10617906_8	1349820.M707_09050	1.604e-22	103.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_3,Flavodoxin_5
WLSH3_k127_10617906_6	671143.DAMO_1946	8.353e-48	186.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
WLSH3_k127_10625625_2	555500.I215_00255	3.479e-05	55.0	COG0697@1|root,COG0697@2|Bacteria,4NEHX@976|Bacteroidetes,1HYA2@117743|Flavobacteriia	976|Bacteroidetes	EG	of the drug metabolite transporter (DMT) superfamily	fjo11	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_10625625_3	177437.HRM2_40030	0.000141	54.0	COG0477@1|root,COG0477@2|Bacteria,1QWNY@1224|Proteobacteria,43BTW@68525|delta/epsilon subdivisions,2X74T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_10625625_0	309807.SRU_0049	1.061e-90	314.0	COG2309@1|root,COG2309@2|Bacteria,4NRU3@976|Bacteroidetes	976|Bacteroidetes	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
WLSH3_k127_10625625_4	439481.Aboo_1091	0.0008097	47.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,3F2FW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03044,ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WLSH3_k127_10625625_1	1273538.G159_07035	2.233e-16	85.0	COG2318@1|root,COG2318@2|Bacteria,1VI69@1239|Firmicutes,4HPG9@91061|Bacilli,26HDR@186818|Planococcaceae	91061|Bacilli	S	DinB family	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
WLSH3_k127_10771787_9	604354.TSIB_2031	6.944e-37	152.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,243PQ@183968|Thermococci	183968|Thermococci	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
WLSH3_k127_10771787_4	589924.Ferp_0854	1.976e-91	317.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,2460N@183980|Archaeoglobi	183980|Archaeoglobi	J	MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
WLSH3_k127_10771787_16	641491.DND132_2396	2.417e-06	53.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,2.7.7.80,2.8.1.11	ko:K00366,ko:K03636,ko:K21029,ko:K21147	ko00910,ko01120,ko04122,map00910,map01120,map04122	M00531	R00790,R07459,R07461	RC00043,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiS
WLSH3_k127_10771787_15	1301100.HG529392_gene4931	2.254e-13	75.0	2E481@1|root,32Z3Y@2|Bacteria,1VFF1@1239|Firmicutes,24SN5@186801|Clostridia,36NFZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10771787_0	1151117.AJLF01000001_gene1051	1.219e-194	619.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
WLSH3_k127_10771787_1	399550.Smar_1113	6.971e-128	424.0	COG0403@1|root,arCOG00077@2157|Archaea,2XQ1W@28889|Crenarchaeota	28889|Crenarchaeota	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
WLSH3_k127_10771787_14	1459636.NTE_02308	1.122e-14	78.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
WLSH3_k127_10771787_6	384616.Pisl_1038	5.042e-59	214.0	COG3294@1|root,arCOG04230@2157|Archaea,2XQ9R@28889|Crenarchaeota	28889|Crenarchaeota	S	phosphohydrolase	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_10771787_8	930945.SiRe_1932	5.127e-38	156.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
WLSH3_k127_10771787_2	1229909.NSED_07730	6.375e-105	351.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
WLSH3_k127_10771787_3	985053.VMUT_0319	1.576e-101	349.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
WLSH3_k127_10771787_7	419665.Maeo_0593	8.047e-43	164.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
WLSH3_k127_10771787_5	351160.LRC287	2.734e-59	214.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
WLSH3_k127_10771787_10	456320.Mvol_0152	6.041e-33	131.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23QZQ@183939|Methanococci	183939|Methanococci	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
WLSH3_k127_10771787_11	391623.TERMP_02183	3.374e-32	139.0	COG0231@1|root,COG1499@1|root,arCOG04149@2157|Archaea,arCOG04277@2157|Archaea,2XUAI@28890|Euryarchaeota,242QZ@183968|Thermococci	183968|Thermococci	J	mRNA decay	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
WLSH3_k127_10771787_12	1121448.DGI_1972	5.194e-21	96.0	COG1433@1|root,COG1433@2|Bacteria,1RDPR@1224|Proteobacteria,42SR6@68525|delta/epsilon subdivisions,2WPP8@28221|Deltaproteobacteria,2MBY2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
WLSH3_k127_10771787_13	593117.TGAM_0853	1.476e-19	92.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,244B2@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
WLSH3_k127_10788299_4	1122176.KB903535_gene2009	0.0007971	51.0	arCOG08211@1|root,2ZBM3@2|Bacteria,4P2GT@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10788299_1	316274.Haur_2917	2.152e-28	129.0	COG4805@1|root,COG4805@2|Bacteria,2G8D3@200795|Chloroflexi	200795|Chloroflexi	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10788299_0	670487.Ocepr_0829	5.487e-56	204.0	COG1409@1|root,COG1409@2|Bacteria,1WKV1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
WLSH3_k127_10788299_2	509191.AEDB02000019_gene4456	1.052e-22	114.0	2DUFI@1|root,33QET@2|Bacteria,1VTMU@1239|Firmicutes,24ZIK@186801|Clostridia,3WMZX@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10788299_3	1499967.BAYZ01000039_gene2211	5.703e-15	79.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
WLSH3_k127_10958107_6	1196322.A370_00841	1.227e-37	157.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_10958107_1	324602.Caur_1774	2.831e-86	308.0	COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi,3758C@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_10958107_10	999630.TUZN_1662	5.646e-11	70.0	COG1695@1|root,arCOG00002@2157|Archaea,2XRBK@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_10958107_7	420247.Msm_0776	1.521e-36	158.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23NN7@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
WLSH3_k127_10958107_3	572478.Vdis_0046	7.194e-61	216.0	COG0163@1|root,arCOG01703@2157|Archaea,2XQJ7@28889|Crenarchaeota	28889|Crenarchaeota	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
WLSH3_k127_10958107_4	1459636.NTE_01027	3.039e-50	195.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_10958107_9	203122.Sde_2049	1.512e-21	110.0	COG5184@1|root,COG5276@1|root,COG5644@1|root,COG5184@2|Bacteria,COG5276@2|Bacteria,COG5644@2|Bacteria,1QX03@1224|Proteobacteria,1T31Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1_2
WLSH3_k127_10958107_2	593750.Metfor_2908	8.14e-86	293.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2NA8Q@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM thiamine pyrophosphate enzyme	porB-2	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_10958107_0	604354.TSIB_1382	5.607e-103	347.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,242N1@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorA	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_10958107_8	694440.JOMF01000004_gene1246	1.061e-25	113.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota	28890|Euryarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	porD	-	1.2.7.1,1.2.7.7	ko:K00171,ko:K00188	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_6
WLSH3_k127_10958107_5	1145276.T479_06045	8.797e-47	179.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,4HC44@91061|Bacilli,3IWIE@400634|Lysinibacillus	91061|Bacilli	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
WLSH3_k127_10960617_25	224325.AF_0799	1.231e-23	108.0	COG0622@1|root,arCOG01141@2157|Archaea,2XXVQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
WLSH3_k127_10960617_2	1041930.Mtc_1125	1.528e-126	432.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
WLSH3_k127_10960617_14	1365176.N186_09635	1.65e-56	210.0	COG0111@1|root,arCOG01757@2157|Archaea	2157|Archaea	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA2	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
WLSH3_k127_10960617_1	368408.Tpen_0817	2.163e-153	499.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WLSH3_k127_10960617_16	693661.Arcve_2003	6.381e-41	157.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,246YM@183980|Archaeoglobi	183980|Archaeoglobi	F	Nicotinamide-nucleotide adenylyltransferase	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
WLSH3_k127_10960617_4	453591.Igni_0532	3.392e-109	363.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
WLSH3_k127_10960617_11	529709.PYCH_11800	1.124e-67	243.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2433Q@183968|Thermococci	183968|Thermococci	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
WLSH3_k127_10960617_19	444157.Tneu_0916	6.002e-37	151.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
WLSH3_k127_10960617_8	378806.STAUR_7200	2.216e-80	285.0	COG1032@1|root,COG1032@2|Bacteria,1RF63@1224|Proteobacteria,42S8Y@68525|delta/epsilon subdivisions,2WNX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
WLSH3_k127_10960617_7	673860.AciM339_0566	6.542e-83	286.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,3F2ET@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
WLSH3_k127_10960617_20	552811.Dehly_0767	2.969e-32	133.0	COG2178@1|root,COG2178@2|Bacteria,2G6RW@200795|Chloroflexi,34CS2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_10960617_18	1183377.Py04_1099	1.303e-37	150.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,242U9@183968|Thermococci	183968|Thermococci	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,HTH_27,HTH_Crp_2,MarR_2
WLSH3_k127_10960617_12	415426.Hbut_0632	2.927e-67	235.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
WLSH3_k127_10960617_27	406327.Mevan_0704	6.187e-23	103.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,23R2C@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
WLSH3_k127_10960617_13	604354.TSIB_1461	1.95e-59	219.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
WLSH3_k127_10960617_29	386456.JQKN01000016_gene901	4.178e-21	105.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_10960617_23	1128421.JAGA01000001_gene2334	1.068e-25	121.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	bplH	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_trans_4_4,Glycos_transf_1
WLSH3_k127_10960617_10	439481.Aboo_0423	4.941e-70	246.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2Y8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WLSH3_k127_10960617_17	439481.Aboo_0424	1.488e-40	160.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y70G@28890|Euryarchaeota,3F32Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_10960617_5	304371.MCP_0633	3.404e-88	297.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota,2N9HS@224756|Methanomicrobia	224756|Methanomicrobia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
WLSH3_k127_10960617_21	1121936.AUHI01000009_gene323	3.258e-31	127.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,4HHF8@91061|Bacilli	91061|Bacilli	P	Belongs to the Fur family	perR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
WLSH3_k127_10960617_39	1437824.BN940_14136	9.39e-06	58.0	28IIF@1|root,2Z8JJ@2|Bacteria,1NUA0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	4.2.1.127,5.4.4.4	ko:K20614	-	-	-	-	ko00000,ko01000	-	-	-	-
WLSH3_k127_10960617_22	1333523.L593_07070	2.431e-30	129.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
WLSH3_k127_10960617_31	509191.AEDB02000033_gene5135	2.663e-19	91.0	2DMZP@1|root,32UMQ@2|Bacteria,1VHU7@1239|Firmicutes,24QKJ@186801|Clostridia,3WKPR@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
WLSH3_k127_10960617_32	29495.EA26_13225	1.115e-17	89.0	COG1247@1|root,COG1247@2|Bacteria,1QUGY@1224|Proteobacteria,1T1YJ@1236|Gammaproteobacteria,1XVDF@135623|Vibrionales	135623|Vibrionales	M	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	yhhY	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
WLSH3_k127_10960617_30	439481.Aboo_1209	1.36e-19	103.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_10960617_26	1122927.KB895415_gene4375	4.307e-23	110.0	COG0454@1|root,COG0456@2|Bacteria,1VFVQ@1239|Firmicutes,4HK5T@91061|Bacilli,26YRH@186822|Paenibacillaceae	91061|Bacilli	K	Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
WLSH3_k127_10960617_28	985665.HPL003_15145	2.998e-21	104.0	COG0454@1|root,COG0456@2|Bacteria,1VFVQ@1239|Firmicutes,4HK5T@91061|Bacilli,26YRH@186822|Paenibacillaceae	91061|Bacilli	K	Histone acetyltransferase HPA2 and related acetyltransferases	ydhI	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
WLSH3_k127_10960617_15	693661.Arcve_0056	1.319e-46	172.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
WLSH3_k127_10960617_41	443218.AS9A_2679	0.0001041	53.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria,232D8@1762|Mycobacteriaceae	201174|Actinobacteria	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
WLSH3_k127_10960617_3	439235.Dalk_0777	1.579e-112	371.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,43AEV@68525|delta/epsilon subdivisions,2WKWE@28221|Deltaproteobacteria,2MJ82@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
WLSH3_k127_10960617_35	688269.Theth_0670	5.132e-15	82.0	COG1670@1|root,COG1670@2|Bacteria,2GDGN@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
WLSH3_k127_10960617_6	1499967.BAYZ01000177_gene5700	1.007e-86	293.0	COG0500@1|root,COG2226@2|Bacteria,2NR7P@2323|unclassified Bacteria	2|Bacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
WLSH3_k127_10960617_38	368408.Tpen_1377	8.603e-08	63.0	arCOG03776@1|root,arCOG03776@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
WLSH3_k127_10960617_34	553973.CLOHYLEM_06322	3.341e-16	87.0	COG2020@1|root,COG2020@2|Bacteria,1VF75@1239|Firmicutes,24NGN@186801|Clostridia	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
WLSH3_k127_10960617_37	1242864.D187_005291	7.853e-09	71.0	COG1572@1|root,COG3055@1|root,COG1572@2|Bacteria,COG3055@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	HYR,Kelch_4,PQQ_2,VCBS
WLSH3_k127_10960617_40	272134.KB731324_gene890	2.235e-05	60.0	COG2931@1|root,COG3210@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G0DX@1117|Cyanobacteria,1H9Z9@1150|Oscillatoriales	1117|Cyanobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,Calx-beta,DUF11,DUF4347,HemolysinCabind,Laminin_G_3,VCBS
WLSH3_k127_10960617_9	548477.HMPREF0294_0332	8.64e-74	286.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
WLSH3_k127_10960617_0	1131266.ARWQ01000001_gene1364	2.07e-153	496.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
WLSH3_k127_10960617_33	589924.Ferp_1520	8.135e-17	84.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,246DI@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
WLSH3_k127_10960617_36	1123372.AUIT01000010_gene400	7.59e-11	73.0	COG0454@1|root,COG0456@2|Bacteria,2GHSZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_10960617_42	1459636.NTE_01468	0.0006973	45.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
WLSH3_k127_11041917_1	658612.MD26_00900	2.854e-10	70.0	COG4886@1|root,COG4886@2|Bacteria,1N4JY@1224|Proteobacteria,1S9T0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SMART leucine-rich repeat-containing protein typical subtype	-	-	-	-	-	-	-	-	-	-	-	-	LRR_4,LRR_8,NEL
WLSH3_k127_11041917_0	1121104.AQXH01000001_gene1465	5.243e-77	281.0	COG1164@1|root,COG1164@2|Bacteria,4NFYH@976|Bacteroidetes	976|Bacteroidetes	E	TIGRFAM oligoendopeptidase, M3 family	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
WLSH3_k127_11343016_0	264732.Moth_0722	1.469e-75	264.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
WLSH3_k127_11343016_1	387631.Asulf_02184	4.397e-24	108.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota,2468P@183980|Archaeoglobi	183980|Archaeoglobi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_11343016_2	509191.AEDB02000021_gene3159	7.406e-07	60.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1TR5C@1239|Firmicutes,25M6Q@186801|Clostridia,3WMKW@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
WLSH3_k127_11390208_0	515635.Dtur_1259	1.369e-148	479.0	COG1350@1|root,COG1350@2|Bacteria	2|Bacteria	E	tryptophan synthase activity	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_11390208_3	706587.Desti_1682	1.791e-75	271.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
WLSH3_k127_11390208_4	926560.KE387023_gene2772	9.911e-15	85.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	AAA_33,ATP-cone
WLSH3_k127_11390208_6	1131266.ARWQ01000005_gene818	0.0002382	50.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
WLSH3_k127_11390208_1	592015.HMPREF1705_00414	2.529e-132	432.0	COG0436@1|root,COG0436@2|Bacteria,3TARZ@508458|Synergistetes	508458|Synergistetes	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
WLSH3_k127_11390208_5	1408321.JNJD01000009_gene1819	1.968e-14	78.0	COG2197@1|root,COG2197@2|Bacteria,1TW4Y@1239|Firmicutes,25B3S@186801|Clostridia,27U0W@186928|unclassified Lachnospiraceae	186801|Clostridia	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
WLSH3_k127_11390208_2	243232.MJ_0649	2.98e-87	304.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,23Q75@183939|Methanococci	183939|Methanococci	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
WLSH3_k127_11465996_5	304371.MCP_2590	9.943e-105	353.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2N9FP@224756|Methanomicrobia	224756|Methanomicrobia	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
WLSH3_k127_11465996_28	397948.Cmaq_0713	4.591e-08	61.0	arCOG05900@1|root,arCOG05900@2157|Archaea,2XRDZ@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
WLSH3_k127_11465996_23	453591.Igni_0828	2.451e-18	89.0	COG3357@1|root,arCOG04479@2157|Archaea,2XR5D@28889|Crenarchaeota	28889|Crenarchaeota	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_11465996_6	593117.TGAM_0434	1.304e-95	328.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,243BB@183968|Thermococci	183968|Thermococci	S	PFAM PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
WLSH3_k127_11465996_13	1183377.Py04_1619	8.271e-55	205.0	COG1063@1|root,arCOG01459@2157|Archaea,2Y683@28890|Euryarchaeota,2450G@183968|Thermococci	183968|Thermococci	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_11465996_15	444157.Tneu_1313	9.81e-38	155.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
WLSH3_k127_11465996_17	572478.Vdis_0984	3.922e-32	132.0	arCOG05489@1|root,arCOG05489@2157|Archaea,2XQT5@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_11465996_33	178306.PAE1316	0.0006429	45.0	arCOG02718@1|root,arCOG02718@2157|Archaea	2157|Archaea	S	TIGRFAM TIGR00304 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
WLSH3_k127_11465996_3	272844.PAB2313	1.093e-174	578.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,24373@183968|Thermococci	183968|Thermococci	L	helicase superfamily c-terminal domain	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
WLSH3_k127_11465996_9	1312954.KI914851_gene1862	1.336e-68	256.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,1W8F3@1268|Micrococcaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
WLSH3_k127_11465996_25	1122919.KB905559_gene1431	2.118e-12	79.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,26RFG@186822|Paenibacillaceae	91061|Bacilli	EGP	Permeases of the major facilitator superfamily	blt9	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,MFS_2,Sugar_tr
WLSH3_k127_11465996_12	391625.PPSIR1_35652	7.643e-55	215.0	COG0433@1|root,COG0433@2|Bacteria,1R7B1@1224|Proteobacteria,42NW4@68525|delta/epsilon subdivisions,2X6WX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_11465996_16	1041930.Mtc_1769	5.526e-33	138.0	COG3382@1|root,arCOG04250@2157|Archaea,2Y2KD@28890|Euryarchaeota,2NAIE@224756|Methanomicrobia	224756|Methanomicrobia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
WLSH3_k127_11465996_21	1347087.CBYO010000005_gene735	4.337e-23	109.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4HA3R@91061|Bacilli	91061|Bacilli	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	nagD	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
WLSH3_k127_11465996_20	70601.3256432	4.219e-24	105.0	COG1917@1|root,arCOG02994@2157|Archaea,2XZAN@28890|Euryarchaeota,2446X@183968|Thermococci	183968|Thermococci	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_11465996_7	1041930.Mtc_0954	2.146e-86	304.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
WLSH3_k127_11465996_22	1408419.JHYG01000001_gene1862	8.25e-22	101.0	COG1051@1|root,COG1051@2|Bacteria,1N1KH@1224|Proteobacteria,2UDD1@28211|Alphaproteobacteria,2JT81@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
WLSH3_k127_11465996_31	3055.EDO99159	1.734e-05	57.0	COG0013@1|root,KOG1155@2759|Eukaryota,37HUX@33090|Viridiplantae,34HDP@3041|Chlorophyta	3041|Chlorophyta	DO	Anaphase promoting complex subunit 8 / Cdc23	APC8	-	-	ko:K03355	ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map04110,map04111,map04113,map04114,map04120,map04914,map05166	M00389	-	-	ko00000,ko00001,ko00002,ko03036,ko04121	-	-	-	ANAPC8,TPR_1,TPR_8
WLSH3_k127_11465996_24	382464.ABSI01000007_gene4185	1.177e-17	93.0	COG4076@1|root,COG4076@2|Bacteria,46W2E@74201|Verrucomicrobia	2|Bacteria	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.319	ko:K11434	ko04068,ko04922,map04068,map04922	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko00001,ko01000,ko03036	-	-	-	Methyltransf_25,Methyltransf_31,PRMT5_C,PrmA
WLSH3_k127_11465996_11	523850.TON_0601	2.314e-57	207.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,24312@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
WLSH3_k127_11465996_8	643648.Slip_0897	2.162e-83	285.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42JJA@68298|Syntrophomonadaceae	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
WLSH3_k127_11465996_10	247490.KSU1_C1165	9.17e-59	214.0	COG0388@1|root,COG0388@2|Bacteria,2IXKW@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
WLSH3_k127_11465996_19	565033.GACE_2045	3.048e-25	109.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ89@28890|Euryarchaeota,247AV@183980|Archaeoglobi	183980|Archaeoglobi	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
WLSH3_k127_11465996_30	1313265.JNIE01000005_gene269	8.37e-06	55.0	COG0457@1|root,COG0457@2|Bacteria,2G407@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
WLSH3_k127_11465996_14	456442.Mboo_0495	7.496e-40	167.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
WLSH3_k127_11465996_26	903814.ELI_4562	2.387e-09	62.0	COG2768@1|root,COG2768@2|Bacteria,1VET2@1239|Firmicutes,24QUH@186801|Clostridia,25XSP@186806|Eubacteriaceae	186801|Clostridia	C	4Fe-4S binding domain	fdxA	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_11465996_4	373903.Hore_16210	5.506e-156	512.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
WLSH3_k127_11465996_32	580332.Slit_2210	0.0001369	51.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,44WAR@713636|Nitrosomonadales	28216|Betaproteobacteria	O	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_11,TPR_12,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
WLSH3_k127_11465996_1	877455.Metbo_1103	6.47e-322	1012.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,23NKS@183925|Methanobacteria	183925|Methanobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WLSH3_k127_11465996_0	1304880.JAGB01000002_gene1765	0.0	1123.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WLSH3_k127_11465996_2	1540221.JQNI01000002_gene2800	6.051e-245	773.0	COG0556@1|root,COG0556@2|Bacteria,1WJ4X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
WLSH3_k127_11465996_18	318464.IO99_03625	5.044e-29	130.0	COG1670@1|root,COG1670@2|Bacteria,1UZR2@1239|Firmicutes,24K9R@186801|Clostridia,36K8T@31979|Clostridiaceae	186801|Clostridia	J	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
WLSH3_k127_11489052_2	797210.Halxa_2990	1.428e-12	70.0	arCOG08146@1|root,arCOG08146@2157|Archaea,2XZH2@28890|Euryarchaeota,23X8V@183963|Halobacteria	183963|Halobacteria	K	Putative antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
WLSH3_k127_11489052_1	797299.HALLA_20355	1.343e-25	110.0	COG1487@1|root,arCOG02219@2157|Archaea,2XX7I@28890|Euryarchaeota,23VMN@183963|Halobacteria	183963|Halobacteria	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
WLSH3_k127_11489052_0	1248916.ANFY01000017_gene1387	7.45e-50	196.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUBW@28211|Alphaproteobacteria,2K2WB@204457|Sphingomonadales	204457|Sphingomonadales	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
WLSH3_k127_11558607_19	374847.Kcr_0565	5.617e-07	61.0	arCOG06883@1|root,arCOG06883@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2334
WLSH3_k127_11558607_22	485918.Cpin_4113	5.401e-05	56.0	COG2911@1|root,COG2911@2|Bacteria,4NHHA@976|Bacteroidetes,1IVM6@117747|Sphingobacteriia	976|Bacteroidetes	M	Domain of unknown function	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG
WLSH3_k127_11558607_6	269797.Mbar_A0881	9.223e-66	238.0	COG1035@1|root,COG3350@1|root,arCOG02650@2157|Archaea,arCOG04507@2157|Archaea,2Y7JA@28890|Euryarchaeota,2NAMA@224756|Methanomicrobia	224756|Methanomicrobia	C	YHS domain	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N,YHS
WLSH3_k127_11558607_3	290397.Adeh_0508	5.799e-72	251.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria,2YV7W@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
WLSH3_k127_11558607_1	760568.Desku_3302	2.314e-137	460.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,249BI@186801|Clostridia,261AA@186807|Peptococcaceae	186801|Clostridia	G	TIGRFAM glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
WLSH3_k127_11558607_20	1193181.BN10_1170025	1.09e-06	58.0	COG0406@1|root,COG0406@2|Bacteria,2HXID@201174|Actinobacteria,4FH0Q@85021|Intrasporangiaceae	201174|Actinobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WLSH3_k127_11558607_7	304371.MCP_1481	1.475e-41	165.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_11558607_0	304371.MCP_1482	8.702e-194	639.0	COG0574@1|root,arCOG01114@2157|Archaea,2XVSY@28890|Euryarchaeota	28890|Euryarchaeota	G	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
WLSH3_k127_11558607_14	529709.PYCH_12180	2.887e-16	89.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
WLSH3_k127_11558607_16	186497.PF1887	1.234e-11	75.0	COG0842@1|root,arCOG01465@2157|Archaea,2Y2BQ@28890|Euryarchaeota,243PC@183968|Thermococci	183968|Thermococci	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
WLSH3_k127_11558607_12	865861.AZSU01000001_gene386	1.34e-21	105.0	COG0842@1|root,COG0842@2|Bacteria,1VI3K@1239|Firmicutes,24AR2@186801|Clostridia,36F7U@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
WLSH3_k127_11558607_2	1033737.CAEV01000022_gene3286	5.676e-76	266.0	COG1131@1|root,COG1131@2|Bacteria,1UHTY@1239|Firmicutes,24JZH@186801|Clostridia,36UHX@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_11558607_17	195522.BD01_0445	2.37e-10	72.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
WLSH3_k127_11558607_4	304371.MCP_1660	5.875e-72	254.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WLSH3_k127_11558607_10	1487953.JMKF01000070_gene3366	5.878e-31	134.0	COG2006@1|root,COG2006@2|Bacteria,1G0X0@1117|Cyanobacteria,1HF8Q@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
WLSH3_k127_11558607_5	304371.MCP_1615	8.395e-66	247.0	COG2202@1|root,arCOG02353@1|root,arCOG02353@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_11558607_11	521011.Mpal_1335	5.969e-22	109.0	COG0784@1|root,arCOG02336@1|root,arCOG02338@1|root,arCOG06712@1|root,arCOG02333@2157|Archaea,arCOG02336@2157|Archaea,arCOG02338@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
WLSH3_k127_11558607_21	981383.AEWH01000031_gene587	2.263e-06	59.0	COG3832@1|root,COG3832@2|Bacteria,1V8GQ@1239|Firmicutes,4HGMI@91061|Bacilli	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
WLSH3_k127_11558607_24	63737.Npun_R5014	0.0004499	51.0	COG0170@1|root,COG0170@2|Bacteria,1GJ5N@1117|Cyanobacteria,1HMBV@1161|Nostocales	1117|Cyanobacteria	I	PFAM phosphatidate cytidylyltransferase	-	-	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	-
WLSH3_k127_11558607_8	742727.HMPREF9447_05392	1.304e-36	149.0	COG0266@1|root,COG0266@2|Bacteria,4NIT4@976|Bacteroidetes,2FPIR@200643|Bacteroidia,4AM38@815|Bacteroidaceae	976|Bacteroidetes	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
WLSH3_k127_11558607_13	388399.SSE37_03590	7.135e-21	101.0	COG4912@1|root,COG4912@2|Bacteria,1NKDG@1224|Proteobacteria,2TU19@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
WLSH3_k127_11558607_15	439481.Aboo_0620	2.291e-15	87.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
WLSH3_k127_11558607_9	5888.CAK72934	3.198e-31	130.0	KOG0084@1|root,KOG0084@2759|Eukaryota,3ZCZ3@5878|Ciliophora	2759|Eukaryota	U	Rab subfamily of small GTPases	-	GO:0003674,GO:0005488,GO:0005515,GO:0019899,GO:0019900,GO:0019901	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_11558607_18	402880.MmarC5_0422	2.692e-07	53.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23QDQ@183939|Methanococci	183939|Methanococci	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WLSH3_k127_125547_1	1229781.C272_12477	3.912e-09	64.0	COG1522@1|root,COG1522@2|Bacteria,2HVG9@201174|Actinobacteria,4F9ZC@85019|Brevibacteriaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_125547_0	673860.AciM339_0292	5.867e-27	128.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03614@2157|Archaea,2XZI4@28890|Euryarchaeota	28890|Euryarchaeota	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
WLSH3_k127_1305579_71	1459636.NTE_02126	6.326e-12	76.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
WLSH3_k127_1305579_52	1035308.AQYY01000001_gene2089	7.548e-26	117.0	COG0454@1|root,COG0456@2|Bacteria,1VHPQ@1239|Firmicutes,24P0Y@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_1305579_20	1123276.KB893262_gene4089	1.753e-60	217.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
WLSH3_k127_1305579_2	485913.Krac_6352	7.62e-146	476.0	COG0402@1|root,COG0402@2|Bacteria,2G6DG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,CYTH
WLSH3_k127_1305579_35	1047013.AQSP01000140_gene2511	5.033e-42	175.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
WLSH3_k127_1305579_41	589924.Ferp_1231	5.736e-35	139.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
WLSH3_k127_1305579_3	555079.Toce_0383	2.51e-144	480.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_1305579_4	926569.ANT_03030	1.26e-108	362.0	COG0167@1|root,COG1148@1|root,COG0167@2|Bacteria,COG1148@2|Bacteria,2G6RH@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
WLSH3_k127_1305579_34	269797.Mbar_A1315	4.636e-42	170.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_1305579_43	563008.HMPREF0665_01844	1.419e-32	138.0	COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,2FM38@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
WLSH3_k127_1305579_75	523841.HFX_2236	5.646e-09	64.0	COG1977@1|root,arCOG00536@2157|Archaea,2XYQA@28890|Euryarchaeota,23WPF@183963|Halobacteria	183963|Halobacteria	H	COG1977 Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
WLSH3_k127_1305579_12	768672.Desfe_0727	1.183e-89	312.0	COG0044@1|root,arCOG00689@2157|Archaea,2XQ3G@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
WLSH3_k127_1305579_55	1365176.N186_08495	3.372e-24	108.0	COG1142@1|root,arCOG01502@2157|Archaea,2XR9N@28889|Crenarchaeota	28889|Crenarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_3,Fer4_4,Fer4_6,Fer4_9
WLSH3_k127_1305579_1	574087.Acear_1487	1.045e-146	486.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_1305579_77	523850.TON_1546	7.223e-09	59.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,245J9@183968|Thermococci	183968|Thermococci	K	regulatory protein AsnC	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
WLSH3_k127_1305579_0	673860.AciM339_1034	2.227e-287	912.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,3F2EY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
WLSH3_k127_1305579_25	1220534.B655_2206	7.421e-53	195.0	COG0842@1|root,arCOG01463@2157|Archaea,2XX4N@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
WLSH3_k127_1305579_14	1220534.B655_2207	8.9e-79	273.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	nosF1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_1305579_67	797209.ZOD2009_01325	8.561e-14	79.0	COG1733@1|root,arCOG01057@2157|Archaea,2Y0R2@28890|Euryarchaeota,23XJ2@183963|Halobacteria	183963|Halobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
WLSH3_k127_1305579_72	1487953.JMKF01000045_gene2892	3.839e-11	75.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,Trypsin_2
WLSH3_k127_1305579_47	2325.TKV_c19080	1.554e-28	120.0	2DMSV@1|root,32TFU@2|Bacteria,1VC0G@1239|Firmicutes,24Q3V@186801|Clostridia,42IQ0@68295|Thermoanaerobacterales	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
WLSH3_k127_1305579_63	2325.TKV_c19090	3.06e-15	80.0	COG4273@1|root,COG4273@2|Bacteria,1VBRH@1239|Firmicutes,24N2C@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
WLSH3_k127_1305579_40	264732.Moth_2218	4.629e-36	148.0	COG0509@1|root,COG4273@1|root,COG0509@2|Bacteria,COG4273@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,42I06@68295|Thermoanaerobacterales	186801|Clostridia	E	DGC domain	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	DGC,GCV_H
WLSH3_k127_1305579_51	2325.TKV_c19110	6.14e-26	109.0	COG1146@1|root,COG1146@2|Bacteria,1VAMF@1239|Firmicutes,24ND9@186801|Clostridia,42IEN@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
WLSH3_k127_1305579_28	931626.Awo_c22580	6.752e-47	171.0	COG1148@1|root,COG1148@2|Bacteria,1V4NY@1239|Firmicutes,24IAD@186801|Clostridia,25YHD@186806|Eubacteriaceae	186801|Clostridia	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1305579_70	398767.Glov_1189	2.524e-12	70.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
WLSH3_k127_1305579_15	580340.Tlie_1774	2.385e-72	256.0	COG0798@1|root,COG0798@2|Bacteria,3TC0V@508458|Synergistetes	508458|Synergistetes	P	PFAM Bile acid sodium symporter	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
WLSH3_k127_1305579_80	1536773.R70331_22205	3.08e-06	57.0	2E39Q@1|root,2ZBHZ@2|Bacteria,1UYTY@1239|Firmicutes,4IEX9@91061|Bacilli,26UQ8@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1305579_68	931277.C448_00637	1.7e-13	81.0	COG3608@1|root,arCOG02890@2157|Archaea,2XTKM@28890|Euryarchaeota,23SB6@183963|Halobacteria	183963|Halobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
WLSH3_k127_1305579_46	1365176.N186_01240	7.85e-29	120.0	arCOG00299@1|root,arCOG00299@2157|Archaea,2XQKR@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1305579_60	643867.Ftrac_2288	3.722e-19	95.0	COG2020@1|root,COG2020@2|Bacteria,4NTXI@976|Bacteroidetes,47RFP@768503|Cytophagia	976|Bacteroidetes	O	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
WLSH3_k127_1305579_11	224325.AF_1299	1.721e-91	311.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_1305579_22	1041930.Mtc_0093	3.751e-56	210.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
WLSH3_k127_1305579_58	573063.Metin_1012	5.488e-21	102.0	COG4088@1|root,arCOG01041@2157|Archaea,2XWNQ@28890|Euryarchaeota,23QTG@183939|Methanococci	183939|Methanococci	F	PFAM Chromatin associated protein KTI12	pstK	-	2.7.1.164	ko:K10837	ko00450,ko00970,map00450,map00970	-	R08223	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	KTI12
WLSH3_k127_1305579_9	647113.Metok_1366	2.528e-98	336.0	KOG4482@1|root,arCOG00119@2157|Archaea,2XV24@28890|Euryarchaeota,23Q57@183939|Methanococci	183939|Methanococci	J	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	spcS	-	2.9.1.2	ko:K03341	ko00450,ko00970,map00450,map00970	-	R08224	RC02965,RC02966	ko00000,ko00001,ko01000	-	-	-	SepSecS
WLSH3_k127_1305579_13	406327.Mevan_0647	5.918e-87	305.0	COG3276@1|root,arCOG01564@2157|Archaea,2Y862@28890|Euryarchaeota,23QEK@183939|Methanococci	183939|Methanococci	J	elongation factor Tu domain 2 protein	selB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2
WLSH3_k127_1305579_59	411468.CLOSCI_02828	2.316e-19	101.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,21YNG@1506553|Lachnoclostridium	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
WLSH3_k127_1305579_54	439481.Aboo_1086	3.154e-24	106.0	COG1051@1|root,COG2005@1|root,arCOG00223@2157|Archaea,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,3F39U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH3_k127_1305579_81	1054217.TALC_00520	0.000134	47.0	arCOG05330@1|root,arCOG05330@2157|Archaea,2Y59I@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1305579_31	706587.Desti_5342	1.437e-44	174.0	COG2144@1|root,COG2144@2|Bacteria,1MVYM@1224|Proteobacteria,42SSN@68525|delta/epsilon subdivisions,2WPNF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
WLSH3_k127_1305579_73	410359.Pcal_0042	4.555e-10	64.0	arCOG05464@1|root,arCOG05464@2157|Archaea,2XR3S@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1305579_30	694429.Pyrfu_1605	1.188e-44	168.0	COG1676@1|root,arCOG01701@2157|Archaea,2XQJB@28889|Crenarchaeota	28889|Crenarchaeota	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
WLSH3_k127_1305579_79	1384049.CD29_13180	2.94e-08	63.0	COG1392@1|root,COG1392@2|Bacteria,1V3AP@1239|Firmicutes,4IRDI@91061|Bacilli,3J087@400634|Lysinibacillus	91061|Bacilli	P	Protein of unknown function DUF47	ykaA	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
WLSH3_k127_1305579_38	589924.Ferp_1929	2.435e-39	158.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
WLSH3_k127_1305579_16	13333.ERM94856	4.588e-72	255.0	COG0003@1|root,KOG2825@2759|Eukaryota,37PA4@33090|Viridiplantae,3G7Q7@35493|Streptophyta	35493|Streptophyta	P	ATPase ASNA1 homolog	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
WLSH3_k127_1305579_74	330779.Saci_0864	9.4e-10	62.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
WLSH3_k127_1305579_8	694429.Pyrfu_1607	1.38e-101	351.0	COG1032@1|root,arCOG01356@2157|Archaea,2XPY0@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
WLSH3_k127_1305579_49	523845.AQXV01000054_gene1637	3.1e-26	111.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23R03@183939|Methanococci	183939|Methanococci	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
WLSH3_k127_1305579_6	224325.AF_1299	4.488e-106	353.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_1305579_21	644281.MFS40622_0392	1.079e-58	215.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,23Q49@183939|Methanococci	183939|Methanococci	J	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WLSH3_k127_1305579_64	365044.Pnap_2813	8.873e-15	79.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_1305579_17	1042877.GQS_10240	1.955e-71	250.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
WLSH3_k127_1305579_53	374847.Kcr_0553	2.232e-25	114.0	COG0746@1|root,arCOG01872@2157|Archaea	2157|Archaea	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
WLSH3_k127_1305579_7	335543.Sfum_4014	1.776e-104	351.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MR11@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
WLSH3_k127_1305579_50	693661.Arcve_0097	3.384e-26	111.0	COG1888@1|root,arCOG04140@2157|Archaea,2Y02A@28890|Euryarchaeota,246DH@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized ArCR, COG1888	-	-	-	ko:K09732	-	-	-	-	ko00000	-	-	-	DUF211
WLSH3_k127_1305579_69	572478.Vdis_1518	4.653e-13	76.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1305579_65	644281.MFS40622_0136	9.321e-15	76.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZY3@28890|Euryarchaeota,23R9B@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
WLSH3_k127_1305579_36	195522.BD01_2153	1.776e-40	154.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,243D0@183968|Thermococci	183968|Thermococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
WLSH3_k127_1305579_23	523850.TON_0072	6.619e-56	206.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
WLSH3_k127_1305579_78	756883.Halar_2474	7.235e-09	59.0	COG0255@1|root,arCOG00785@2157|Archaea	2157|Archaea	J	Belongs to the universal ribosomal protein uL29 family	rpl29	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
WLSH3_k127_1305579_62	339860.Msp_0900	2.616e-15	78.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
WLSH3_k127_1305579_44	521011.Mpal_0451	4.637e-31	125.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
WLSH3_k127_1305579_32	673860.AciM339_1108	1.827e-44	165.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,3F2NF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
WLSH3_k127_1305579_45	272557.APE_0358	6.486e-30	124.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
WLSH3_k127_1305579_19	591019.Shell_1432	3.247e-66	233.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
WLSH3_k127_1305579_24	391623.TERMP_00105	5.819e-53	192.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,242J0@183968|Thermococci	183968|Thermococci	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
WLSH3_k127_1305579_66	368408.Tpen_0241	1.558e-14	74.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
WLSH3_k127_1305579_26	342949.PNA2_0366	2.305e-51	184.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
WLSH3_k127_1305579_29	1198449.ACAM_0261	6.596e-45	169.0	COG0097@1|root,arCOG04090@2157|Archaea,2XQ9A@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
WLSH3_k127_1305579_57	768679.TTX_1822	4.235e-21	104.0	COG1717@1|root,arCOG00781@2157|Archaea,2XQI2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
WLSH3_k127_1305579_37	1041930.Mtc_1341	9.368e-40	152.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,2N9QQ@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
WLSH3_k127_1305579_27	693661.Arcve_0966	9.762e-48	180.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2463G@183980|Archaeoglobi	183980|Archaeoglobi	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
WLSH3_k127_1305579_18	633148.Tagg_0867	4.562e-70	243.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
WLSH3_k127_1305579_42	877455.Metbo_0796	6.566e-35	138.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,23P1Y@183925|Methanobacteria	183925|Methanobacteria	J	ribosomal protein	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
WLSH3_k127_1305579_48	765177.Desmu_0890	1.293e-27	118.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
WLSH3_k127_1305579_56	523845.AQXV01000054_gene1622	7.42e-24	106.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,23QYJ@183939|Methanococci	183939|Methanococci	J	Binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
WLSH3_k127_1305579_5	28583.AMAG_13818T0	1.284e-108	369.0	COG0201@1|root,KOG1373@2759|Eukaryota,38FS7@33154|Opisthokonta,3NWHW@4751|Fungi	4751|Fungi	U	protein transport protein sec61	SEC61	GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005783,GO:0005784,GO:0005789,GO:0005791,GO:0005886,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006620,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0008104,GO:0008150,GO:0008152,GO:0008320,GO:0008565,GO:0009056,GO:0009057,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0012505,GO:0015031,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0019538,GO:0019941,GO:0022804,GO:0022857,GO:0022884,GO:0030163,GO:0030433,GO:0030867,GO:0030970,GO:0031090,GO:0031204,GO:0031224,GO:0031984,GO:0032527,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0033554,GO:0034613,GO:0034976,GO:0036503,GO:0042175,GO:0042221,GO:0042277,GO:0042886,GO:0042887,GO:0043021,GO:0043022,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0044877,GO:0045047,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051603,GO:0051641,GO:0051649,GO:0051716,GO:0055085,GO:0065002,GO:0070727,GO:0070843,GO:0070972,GO:0071256,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0098588,GO:0098796,GO:0098827,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1903513,GO:1904680	-	ko:K10956	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Plug_translocon,SecY
WLSH3_k127_1305579_39	330084.JNYZ01000007_gene8670	1.218e-36	152.0	COG3608@1|root,COG3608@2|Bacteria,2IC8T@201174|Actinobacteria,4EAUN@85010|Pseudonocardiales	201174|Actinobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
WLSH3_k127_1305579_10	1220534.B655_1297	3.886e-92	313.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1305579_33	579137.Metvu_0207	2.989e-43	164.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,23Q7F@183939|Methanococci	183939|Methanococci	F	ATP-AMP transphosphorylase	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
WLSH3_k127_1305579_76	879212.DespoDRAFT_03064	6.6e-09	64.0	COG0675@1|root,COG0675@2|Bacteria,1QAHQ@1224|Proteobacteria,432U8@68525|delta/epsilon subdivisions,2WX81@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Putative transposase DNA-binding domain	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_Zn_ribbon
WLSH3_k127_1317496_4	439497.RR11_1329	3.564e-21	94.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,4N9WG@97050|Ruegeria	28211|Alphaproteobacteria	K	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,LMWPc
WLSH3_k127_1317496_2	368407.Memar_0366	2.805e-23	110.0	COG2006@1|root,arCOG02447@2157|Archaea,2XW1U@28890|Euryarchaeota,2N9D9@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_7
WLSH3_k127_1317496_3	608506.COB47_2094	1.019e-21	102.0	COG0655@1|root,COG0655@2|Bacteria,1UZKQ@1239|Firmicutes,25CAS@186801|Clostridia,42JEW@68295|Thermoanaerobacterales	186801|Clostridia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
WLSH3_k127_1317496_0	926692.AZYG01000086_gene736	4.586e-27	121.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,24D2S@186801|Clostridia,3WBYU@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
WLSH3_k127_1317496_1	401053.AciPR4_1445	1.299e-23	113.0	COG2159@1|root,COG2159@2|Bacteria,3Y2HY@57723|Acidobacteria,2JI2D@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
WLSH3_k127_1317496_5	1304872.JAGC01000009_gene448	9.213e-08	59.0	arCOG08935@1|root,338YH@2|Bacteria,1N8JH@1224|Proteobacteria,43DKA@68525|delta/epsilon subdivisions,2WSNG@28221|Deltaproteobacteria,2MDSR@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1348078_32	1185653.A1A1_14699	0.0001795	53.0	COG0477@1|root,COG2814@2|Bacteria,1TSR2@1239|Firmicutes,4HD8G@91061|Bacilli,26D8S@186818|Planococcaceae	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
WLSH3_k127_1348078_27	1071073.KI530551_gene3732	3.212e-09	66.0	COG2259@1|root,COG2259@2|Bacteria,1V4ER@1239|Firmicutes,4HGZN@91061|Bacilli,1ZEVR@1386|Bacillus	91061|Bacilli	S	DoxX	M1-1022	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
WLSH3_k127_1348078_13	386456.JQKN01000001_gene1715	2.714e-54	204.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23NK4@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
WLSH3_k127_1348078_33	330779.Saci_1979	0.0001846	49.0	COG0640@1|root,arCOG03859@2157|Archaea	2157|Archaea	K	ligase activity	-	-	-	ko:K00666,ko:K03892	-	-	-	-	ko00000,ko01000,ko01004,ko03000	-	-	-	HTH_20,HTH_5
WLSH3_k127_1348078_11	195522.BD01_1631	4.439e-71	248.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,243M3@183968|Thermococci	183968|Thermococci	E	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_1348078_12	932678.THERU_00510	1.211e-66	233.0	COG0036@1|root,COG0036@2|Bacteria,2G3WZ@200783|Aquificae	200783|Aquificae	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
WLSH3_k127_1348078_7	247490.KSU1_C1252	2.736e-90	301.0	COG0176@1|root,COG0176@2|Bacteria,2J0IB@203682|Planctomycetes	203682|Planctomycetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	TAL_FSA
WLSH3_k127_1348078_6	662479.C440_10373	1.018e-91	320.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
WLSH3_k127_1348078_5	1131269.AQVV01000007_gene1038	5.53e-102	354.0	COG0323@1|root,COG0323@2|Bacteria	2|Bacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391	2.1.1.37	ko:K00558,ko:K03572	ko00270,ko01100,ko03430,ko05206,map00270,map01100,map03430,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
WLSH3_k127_1348078_28	906888.JCM19314_904	2.578e-08	69.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1348078_14	584708.Apau_0482	1.485e-43	164.0	COG1528@1|root,COG1528@2|Bacteria,3TB3G@508458|Synergistetes	508458|Synergistetes	P	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
WLSH3_k127_1348078_8	1157490.EL26_11975	1.278e-75	278.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
WLSH3_k127_1348078_19	523850.TON_1638	3.245e-24	108.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2441Z@183968|Thermococci	183968|Thermococci	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
WLSH3_k127_1348078_9	760568.Desku_2708	9.674e-74	264.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
WLSH3_k127_1348078_22	649747.HMPREF0083_01431	1.72e-20	96.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,4IRSH@91061|Bacilli,26YXT@186822|Paenibacillaceae	91061|Bacilli	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
WLSH3_k127_1348078_25	857290.HMPREF9156_01203	3.811e-14	78.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,4D10F@85004|Bifidobacteriales	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K07443	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
WLSH3_k127_1348078_3	1343739.PAP_02875	3.084e-131	436.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,242X6@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
WLSH3_k127_1348078_0	693661.Arcve_1203	3.369e-166	533.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
WLSH3_k127_1348078_29	195522.BD01_1811	3.917e-06	58.0	COG1572@1|root,COG3889@1|root,arCOG02497@1|root,arCOG02499@1|root,arCOG02545@1|root,arCOG02554@1|root,arCOG03439@1|root,arCOG01672@2157|Archaea,arCOG02497@2157|Archaea,arCOG02499@2157|Archaea,arCOG02545@2157|Archaea,arCOG02554@2157|Archaea,arCOG03439@2157|Archaea,arCOG07086@2157|Archaea,2XU6I@28890|Euryarchaeota,245EQ@183968|Thermococci	183968|Thermococci	S	solute binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_1348078_18	529709.PYCH_15790	6.91e-25	118.0	COG0013@1|root,arCOG01254@2157|Archaea,2XZ9G@28890|Euryarchaeota,243MX@183968|Thermococci	183968|Thermococci	J	alanyl-tRNA	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WLSH3_k127_1348078_21	926569.ANT_11560	2.063e-22	112.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
WLSH3_k127_1348078_17	399550.Smar_0350	5.046e-25	118.0	COG1602@1|root,arCOG04269@2157|Archaea,2XPMN@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Archaeal protein of	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
WLSH3_k127_1348078_23	1365176.N186_06505	2.099e-20	103.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2XSKE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Zinc finger TFIIB-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
WLSH3_k127_1348078_30	1410624.JNKK01000062_gene1076	6.055e-06	58.0	COG1594@1|root,COG1594@2|Bacteria,1UHVH@1239|Firmicutes,25E4D@186801|Clostridia,27UIJ@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1348078_2	304371.MCP_1409	4.441e-135	441.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
WLSH3_k127_1348078_16	273116.14324400	3.425e-30	126.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,241RM@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
WLSH3_k127_1348078_4	123214.PERMA_0400	5.77e-126	415.0	COG1812@1|root,COG1812@2|Bacteria,2G3UM@200783|Aquificae	200783|Aquificae	E	PFAM S-adenosylmethionine synthetase (MAT)	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
WLSH3_k127_1348078_1	109760.SPPG_06527T0	3.162e-137	460.0	COG0339@1|root,KOG2089@2759|Eukaryota,38SFI@33154|Opisthokonta,3NX1E@4751|Fungi	4751|Fungi	O	metallopeptidase MepB	PRD1	GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005773,GO:0005794,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0012505,GO:0016787,GO:0019538,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0034641,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070011,GO:0070013,GO:0071704,GO:0140096,GO:1901564	3.4.24.37	ko:K01405,ko:K13726	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
WLSH3_k127_1348078_26	304371.MCP_2737	8.92e-12	73.0	arCOG05710@1|root,arCOG05710@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1348078_15	797209.ZOD2009_05197	6.926e-41	160.0	COG1234@1|root,arCOG00500@2157|Archaea,2XTUD@28890|Euryarchaeota,23STE@183963|Halobacteria	183963|Halobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
WLSH3_k127_1348078_10	368408.Tpen_1035	1.29e-71	253.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
WLSH3_k127_1348078_20	1265503.KB905160_gene2775	8.203e-23	114.0	COG0265@1|root,COG3266@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3266@2|Bacteria,COG3291@2|Bacteria,1MWCG@1224|Proteobacteria,1RZKK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1565
WLSH3_k127_1348078_24	1270196.JCKI01000008_gene1708	1.823e-17	97.0	COG2234@1|root,COG2234@2|Bacteria,4NENF@976|Bacteroidetes,1IPRF@117747|Sphingobacteriia	976|Bacteroidetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
WLSH3_k127_1461761_76	1219076.N646_3200	9.145e-15	76.0	COG1122@1|root,COG1122@2|Bacteria,1R7WS@1224|Proteobacteria,1S3U3@1236|Gammaproteobacteria,1XSU1@135623|Vibrionales	135623|Vibrionales	P	COG1122 ABC-type cobalt transport system, ATPase component	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,DUF3744
WLSH3_k127_1461761_35	351160.LRC325	2.15e-53	202.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	ABC_cobalt,Oxidored_molyb
WLSH3_k127_1461761_57	646529.Desaci_3921	2.769e-32	141.0	COG1409@1|root,COG1409@2|Bacteria,1VDYM@1239|Firmicutes,24GDB@186801|Clostridia,262VZ@186807|Peptococcaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
WLSH3_k127_1461761_77	351160.LRC332	1.909e-12	77.0	arCOG01190@1|root,arCOG01190@2157|Archaea	351160.LRC332|-	G	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1461761_68	1304880.JAGB01000002_gene1571	9.22e-23	98.0	2E32K@1|root,32Y2U@2|Bacteria,1VFFP@1239|Firmicutes,24RID@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1461761_21	694429.Pyrfu_1298	2.637e-89	305.0	COG0182@1|root,arCOG01123@2157|Archaea,2XPZU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
WLSH3_k127_1461761_58	224719.Abm4_0986	2.212e-31	129.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23P79@183925|Methanobacteria	183925|Methanobacteria	C	hydrogenase maturation protease HycI	hycI	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
WLSH3_k127_1461761_72	386456.JQKN01000001_gene1826	4.714e-18	93.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,23P3J@183925|Methanobacteria	183925|Methanobacteria	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
WLSH3_k127_1461761_13	186497.PF1041	1.987e-120	399.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,242R1@183968|Thermococci	183968|Thermococci	V	K homology RNA-binding domain	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
WLSH3_k127_1461761_34	118166.JH976537_gene1412	9.537e-55	199.0	COG0120@1|root,COG0120@2|Bacteria,1G2DW@1117|Cyanobacteria,1H811@1150|Oscillatoriales	1117|Cyanobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.rpiA	Rib_5-P_isom_A
WLSH3_k127_1461761_83	1034807.FBFL15_1098	1.923e-09	65.0	COG4894@1|root,COG4894@2|Bacteria,4NK2I@976|Bacteroidetes,1ICNE@117743|Flavobacteriia,2NTRI@237|Flavobacterium	976|Bacteroidetes	S	Scramblase	-	-	-	-	-	-	-	-	-	-	-	-	Scramblase
WLSH3_k127_1461761_75	272563.CD630_17630	5.883e-15	78.0	COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,25U6W@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
WLSH3_k127_1461761_19	877455.Metbo_2400	1.314e-98	335.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,23NUN@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
WLSH3_k127_1461761_0	1365176.N186_02820	6.17e-202	647.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
WLSH3_k127_1461761_11	694429.Pyrfu_0958	5.64e-126	421.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
WLSH3_k127_1461761_70	1125863.JAFN01000001_gene2643	8.39e-20	96.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,42U2Q@68525|delta/epsilon subdivisions,2WQK9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
WLSH3_k127_1461761_50	1042877.GQS_08070	1.311e-37	152.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
WLSH3_k127_1461761_56	195522.BD01_1951	8.02e-34	136.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2438P@183968|Thermococci	183968|Thermococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
WLSH3_k127_1461761_86	1054217.TALC_00161	1.492e-08	64.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,241WK@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
WLSH3_k127_1461761_8	572546.Arcpr_1629	4.24e-142	462.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
WLSH3_k127_1461761_40	751944.HALDL1_01855	1.374e-46	178.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,23RZ2@183963|Halobacteria	183963|Halobacteria	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
WLSH3_k127_1461761_67	391623.TERMP_01563	1.902e-23	104.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,244FN@183968|Thermococci	183968|Thermococci	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
WLSH3_k127_1461761_38	634498.mru_0703	3.07e-50	185.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,23NYI@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
WLSH3_k127_1461761_87	1117319.PSPO_11942	3.462e-07	62.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2PZW7@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	U	COG3267 Type II secretory pathway, component ExeA	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1,T2SSB
WLSH3_k127_1461761_14	70601.3257174	3.23e-119	398.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242UT@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
WLSH3_k127_1461761_1	877455.Metbo_0232	1.141e-183	601.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
WLSH3_k127_1461761_47	484019.THA_952	8.463e-39	152.0	COG1014@1|root,COG1014@2|Bacteria,2GEBN@200918|Thermotogae	200918|Thermotogae	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
WLSH3_k127_1461761_3	439481.Aboo_0302	1.452e-177	578.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
WLSH3_k127_1461761_9	1047013.AQSP01000045_gene109	2.387e-127	420.0	COG0686@1|root,COG0686@2|Bacteria,2NNTE@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	sdh	-	1.5.1.7,1.5.1.8,1.5.1.9	ko:K00290,ko:K14157	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R00716,R02313	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
WLSH3_k127_1461761_7	1499967.BAYZ01000013_gene6445	9.326e-143	465.0	COG1748@1|root,COG1748@2|Bacteria,2NNZ1@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lys2	-	1.5.1.10	ko:K00293	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R02315	RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
WLSH3_k127_1461761_92	1041930.Mtc_1493	0.0004426	50.0	arCOG04038@1|root,arCOG04038@2157|Archaea,2Y5TS@28890|Euryarchaeota,2NBDA@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1461761_66	523845.AQXV01000026_gene1483	1.13e-24	115.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23QQY@183939|Methanococci	183939|Methanococci	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
WLSH3_k127_1461761_45	886882.PPSC2_c1692	7.688e-41	166.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,26RKR@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
WLSH3_k127_1461761_4	1042877.GQS_01015	1.661e-170	554.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
WLSH3_k127_1461761_48	673860.AciM339_0977	1.221e-38	146.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,3F2QH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WLSH3_k127_1461761_53	339860.Msp_0857	4.487e-36	147.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WLSH3_k127_1461761_73	469371.Tbis_0467	4.844e-18	100.0	COG0433@1|root,COG0433@2|Bacteria,2HJ0Q@201174|Actinobacteria,4DZ21@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function DUF87	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
WLSH3_k127_1461761_88	69014.TK0421	6.978e-06	48.0	arCOG07843@1|root,arCOG07843@2157|Archaea	69014.TK0421|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1461761_65	1380356.JNIK01000021_gene4561	1.659e-25	123.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system protein e	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
WLSH3_k127_1461761_82	1229909.NSED_09705	1.582e-09	69.0	COG1405@1|root,arCOG01981@2157|Archaea	2157|Archaea	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
WLSH3_k127_1461761_16	573063.Metin_0090	3.215e-112	374.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23RI4@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_1461761_24	694429.Pyrfu_1938	4.761e-83	290.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
WLSH3_k127_1461761_80	666510.ASAC_1325	8.741e-12	69.0	COG0640@1|root,arCOG04056@2157|Archaea,2XR0A@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
WLSH3_k127_1461761_54	386456.JQKN01000002_gene2598	2.593e-34	143.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,23NZW@183925|Methanobacteria	183925|Methanobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
WLSH3_k127_1461761_31	415426.Hbut_0906	4.65e-63	231.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
WLSH3_k127_1461761_17	573064.Mefer_1399	7.558e-108	359.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
WLSH3_k127_1461761_5	368408.Tpen_0497	2.34e-169	555.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
WLSH3_k127_1461761_2	1094980.Mpsy_2704	9.177e-178	582.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
WLSH3_k127_1461761_26	309801.trd_0179	4.855e-78	273.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi,27XTE@189775|Thermomicrobia	189775|Thermomicrobia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
WLSH3_k127_1461761_51	1056495.Calag_0427	1.738e-37	148.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
WLSH3_k127_1461761_20	877455.Metbo_2444	8.178e-93	318.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,23NRE@183925|Methanobacteria	183925|Methanobacteria	O	AAA ATPase	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
WLSH3_k127_1461761_41	694429.Pyrfu_0043	8.324e-45	169.0	COG0237@1|root,arCOG01045@2157|Archaea,2XQTJ@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,AAA_18
WLSH3_k127_1461761_81	693661.Arcve_2025	3.247e-10	66.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,245NW@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,RNA_binding
WLSH3_k127_1461761_52	386456.JQKN01000002_gene2681	2.398e-37	154.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
WLSH3_k127_1461761_32	930945.SiRe_1049	9.651e-62	221.0	COG1100@1|root,arCOG01225@2157|Archaea,2XQ2Q@28889|Crenarchaeota	28889|Crenarchaeota	S	ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
WLSH3_k127_1461761_33	69014.TK1688	2.756e-61	224.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
WLSH3_k127_1461761_27	1459636.NTE_01027	6.827e-77	273.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_1461761_64	1125863.JAFN01000001_gene3506	7.462e-27	120.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
WLSH3_k127_1461761_6	886377.Murru_2360	1.687e-165	537.0	COG0504@1|root,COG0504@2|Bacteria,4NEWT@976|Bacteroidetes,1HWP2@117743|Flavobacteriia	976|Bacteroidetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
WLSH3_k127_1461761_37	387631.Asulf_00667	1.14e-50	199.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,246V1@183980|Archaeoglobi	183980|Archaeoglobi	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
WLSH3_k127_1461761_69	694429.Pyrfu_0798	2.025e-20	93.0	COG0640@1|root,arCOG01679@2157|Archaea,2XR0G@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_1461761_22	192952.MM_3080	6.299e-88	315.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
WLSH3_k127_1461761_79	1459636.NTE_01725	6.167e-12	70.0	COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
WLSH3_k127_1461761_15	868131.MSWAN_2418	4.528e-114	377.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
WLSH3_k127_1461761_42	69014.TK0679	2.106e-43	166.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
WLSH3_k127_1461761_43	579137.Metvu_1548	5.835e-43	164.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,23QST@183939|Methanococci	183939|Methanococci	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
WLSH3_k127_1461761_91	342949.PNA2_0594	0.0001152	54.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2432S@183968|Thermococci	183968|Thermococci	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
WLSH3_k127_1461761_30	186497.PF0022	8.372e-65	241.0	COG1530@1|root,arCOG04307@2157|Archaea,2XUGB@28890|Euryarchaeota,243F3@183968|Thermococci	183968|Thermococci	J	Binds to RNA in loop regions with AU-rich sequences	aubA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K22469	-	-	-	-	ko00000,ko03009	-	-	-	DUF402,RNase_E_G
WLSH3_k127_1461761_71	415426.Hbut_1631	4.981e-19	90.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
WLSH3_k127_1461761_85	1163730.FFONT_0844	5.67e-09	62.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
WLSH3_k127_1461761_39	439481.Aboo_0633	3.91e-48	183.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,3F2MY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
WLSH3_k127_1461761_18	1343739.PAP_05030	2.311e-99	341.0	COG1109@1|root,arCOG00767@2157|Archaea,2XTYZ@28890|Euryarchaeota,242U1@183968|Thermococci	183968|Thermococci	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.7	ko:K22199	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WLSH3_k127_1461761_55	436308.Nmar_1717	7.455e-34	143.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
WLSH3_k127_1461761_25	579137.Metvu_0644	1.053e-81	293.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,23QFR@183939|Methanococci	183939|Methanococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos
WLSH3_k127_1461761_12	1094980.Mpsy_1728	3.525e-121	401.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
WLSH3_k127_1461761_44	1041930.Mtc_1738	5.252e-41	161.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,2N9NN@224756|Methanomicrobia	224756|Methanomicrobia	Q	methyltransferase small	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
WLSH3_k127_1461761_62	453591.Igni_0577	1.674e-28	124.0	COG1096@1|root,arCOG00676@2157|Archaea,2XQRA@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,S1
WLSH3_k127_1461761_84	420247.Msm_1356	3.247e-09	61.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
WLSH3_k127_1461761_78	69014.TK1166	5.956e-12	71.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
WLSH3_k127_1461761_63	1343739.PAP_03275	8.334e-28	116.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
WLSH3_k127_1461761_59	397948.Cmaq_1377	2.899e-30	129.0	COG0592@1|root,arCOG00488@2157|Archaea,2XQCF@28889|Crenarchaeota	28889|Crenarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
WLSH3_k127_1461761_46	604354.TSIB_0565	1.923e-39	157.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2434V@183968|Thermococci	183968|Thermococci	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N,Rad1
WLSH3_k127_1461761_36	368408.Tpen_0622	1.721e-51	200.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
WLSH3_k127_1461761_89	1459636.NTE_00425	1.922e-05	55.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
WLSH3_k127_1461761_61	706587.Desti_0171	1.874e-29	124.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
WLSH3_k127_1461761_29	579137.Metvu_0280	8.343e-69	244.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_1461761_28	351160.LRC437	4.111e-74	264.0	COG1148@1|root,arCOG02236@2157|Archaea,2XV85@28890|Euryarchaeota,2NABC@224756|Methanomicrobia	224756|Methanomicrobia	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3	ko:K22480	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
WLSH3_k127_1461761_23	693661.Arcve_1116	1.207e-87	317.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02475@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	28890|Euryarchaeota	C	Heterodisulfide reductase subunit A and related polyferredoxins	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_4,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
WLSH3_k127_1461761_93	398579.Spea_3966	0.0005664	53.0	COG0437@1|root,COG0437@2|Bacteria,1NBNQ@1224|Proteobacteria,1RQJG@1236|Gammaproteobacteria,2Q9JM@267890|Shewanellaceae	1236|Gammaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	nrfC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0042279,GO:0055114,GO:0098809	-	ko:K00184,ko:K04014	-	-	-	-	ko00000	5.A.3	-	iUMNK88_1353.UMNK88_4933	Fer4,Fer4_11,Fer4_3,Fer4_4
WLSH3_k127_1461761_10	177437.HRM2_17530	4.547e-127	417.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_1461761_60	386456.JQKN01000012_gene972	1.66e-29	122.0	COG0662@1|root,arCOG03003@2157|Archaea,2Y1J0@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_1461761_49	573064.Mefer_0238	7.99e-38	145.0	COG1908@1|root,arCOG02475@2157|Archaea,2XXAU@28890|Euryarchaeota,23QYD@183939|Methanococci	183939|Methanococci	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
WLSH3_k127_1461761_74	572546.Arcpr_1178	1.034e-17	86.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2XZI9@28890|Euryarchaeota	28890|Euryarchaeota	K	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
WLSH3_k127_1461761_90	195522.BD01_2072	0.0001124	46.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y0GG@28890|Euryarchaeota,2448Z@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF3368)	-	-	-	ko:K07066	-	-	-	-	ko00000	-	-	-	DUF3368
WLSH3_k127_1663200_1	1536772.R70723_01100	2.275e-18	95.0	28IEB@1|root,2Z8GD@2|Bacteria,1VCER@1239|Firmicutes,4I70C@91061|Bacilli,26VR2@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037
WLSH3_k127_1663200_0	1219084.AP014508_gene567	3.814e-84	285.0	COG0334@1|root,COG0334@2|Bacteria,2GCH4@200918|Thermotogae	200918|Thermotogae	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iLJ478.TM1015	ELFV_dehydrog,ELFV_dehydrog_N
WLSH3_k127_1733189_6	861299.J421_1555	1.82e-07	59.0	COG2318@1|root,COG2318@2|Bacteria,1ZV6X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
WLSH3_k127_1733189_4	593117.TGAM_0969	1.096e-24	119.0	arCOG02559@1|root,arCOG02559@2157|Archaea,2Y0CM@28890|Euryarchaeota,245E0@183968|Thermococci	183968|Thermococci	S	by modhmm	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,PEGA
WLSH3_k127_1733189_0	304371.MCP_2203	8.681e-42	164.0	COG1266@1|root,arCOG02766@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_1733189_2	529709.PYCH_18030	2.361e-26	111.0	COG1487@1|root,arCOG02219@2157|Archaea,2Y4FC@28890|Euryarchaeota,244JI@183968|Thermococci	183968|Thermococci	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
WLSH3_k127_1733189_5	391623.TERMP_02109	1.044e-09	63.0	arCOG07235@1|root,arCOG07235@2157|Archaea,2Y3YM@28890|Euryarchaeota,244IE@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1733189_3	926561.KB900622_gene463	6.451e-25	109.0	29X3G@1|root,30IS5@2|Bacteria,1W5BE@1239|Firmicutes,24MZE@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
WLSH3_k127_1733189_1	439481.Aboo_1209	3.853e-27	127.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_1824167_23	1499683.CCFF01000016_gene635	8.838e-24	103.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,36EJH@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WLSH3_k127_1824167_6	273068.TTE0459	1.883e-75	272.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,42FNB@68295|Thermoanaerobacterales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WLSH3_k127_1824167_0	1089548.KI783301_gene718	3.405e-158	518.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,4HVSH@91061|Bacilli,3WDXK@539002|Bacillales incertae sedis	91061|Bacilli	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
WLSH3_k127_1824167_12	309799.DICTH_1024	9.797e-57	211.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
WLSH3_k127_1824167_2	1122925.KB895381_gene3810	8.023e-148	484.0	COG0702@1|root,COG0702@2|Bacteria,1UNWK@1239|Firmicutes,4IUSY@91061|Bacilli,277RE@186822|Paenibacillaceae	91061|Bacilli	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_1824167_30	7955.ENSDARP00000057623	4.479e-09	67.0	KOG3780@1|root,KOG3780@2759|Eukaryota,39WQT@33154|Opisthokonta,3BII6@33208|Metazoa,3D5BZ@33213|Bilateria,48B05@7711|Chordata,4983M@7742|Vertebrata,4A1RI@7898|Actinopterygii	33208|Metazoa	S	Zgc 110353	-	-	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
WLSH3_k127_1824167_27	1238184.CM001792_gene127	1.295e-16	92.0	COG4552@1|root,COG4552@2|Bacteria,1TRPM@1239|Firmicutes,4HD22@91061|Bacilli,23ITM@182709|Oceanobacillus	91061|Bacilli	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
WLSH3_k127_1824167_18	351160.RCIX1600	1.148e-39	157.0	COG0778@1|root,arCOG00288@2157|Archaea	2157|Archaea	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
WLSH3_k127_1824167_34	1192034.CAP_7959	3.267e-07	55.0	COG3831@1|root,COG3831@2|Bacteria,1QX5X@1224|Proteobacteria,43BYH@68525|delta/epsilon subdivisions,2X79D@28221|Deltaproteobacteria,2Z3EB@29|Myxococcales	28221|Deltaproteobacteria	S	Proposed nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	WGR
WLSH3_k127_1824167_21	161934.XP_010677114.1	1.417e-31	130.0	KOG0084@1|root,KOG0084@2759|Eukaryota,37JSX@33090|Viridiplantae,3GAR8@35493|Streptophyta	35493|Streptophyta	U	Ras-related protein	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_1824167_4	443254.Marpi_0537	1.129e-79	290.0	COG1164@1|root,COG1164@2|Bacteria,2GCJ4@200918|Thermotogae	200918|Thermotogae	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
WLSH3_k127_1824167_15	926561.KB900617_gene1868	2.067e-51	193.0	COG0491@1|root,COG0491@2|Bacteria,1VHN6@1239|Firmicutes,24AT7@186801|Clostridia	186801|Clostridia	S	Zn-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_1824167_10	999630.TUZN_1169	2.057e-61	218.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
WLSH3_k127_1824167_11	999630.TUZN_1169	9.856e-61	215.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
WLSH3_k127_1824167_17	28377.ENSACAP00000008418	6.042e-47	180.0	COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,47ZN8@7711|Chordata,494ZR@7742|Vertebrata	33208|Metazoa	E	asparagine catabolic process via L-aspartate	ASRGL1	GO:0003674,GO:0003824,GO:0004067,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006528,GO:0006530,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008798,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019439,GO:0019538,GO:0019752,GO:0032787,GO:0033345,GO:0034641,GO:0042737,GO:0043170,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0070011,GO:0071704,GO:0072329,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
WLSH3_k127_1824167_24	572546.Arcpr_0016	3.857e-19	94.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2466S@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH3_k127_1824167_19	1121405.dsmv_1706	4.063e-35	147.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2MIE6@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_1824167_3	247490.KSU1_D1051	1.853e-115	389.0	COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes	203682|Planctomycetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
WLSH3_k127_1824167_39	504832.OCAR_5309	0.0001436	51.0	COG2020@1|root,COG2020@2|Bacteria,1RECR@1224|Proteobacteria,2U6MH@28211|Alphaproteobacteria,3JYJP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
WLSH3_k127_1824167_5	643648.Slip_1068	3.021e-77	268.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,42JI7@68298|Syntrophomonadaceae	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_1824167_35	562970.Btus_2216	8.751e-07	63.0	COG2374@1|root,COG3225@1|root,COG5492@1|root,COG2374@2|Bacteria,COG3225@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
WLSH3_k127_1824167_32	386456.JQKN01000007_gene3354	2.794e-08	61.0	COG1417@1|root,arCOG04850@2157|Archaea	2157|Archaea	S	to GB L77117 SP Q58031 PID 1591324 percent identity	-	-	-	-	-	-	-	-	-	-	-	-	DUF22
WLSH3_k127_1824167_37	640513.Entas_4042	2.454e-05	50.0	COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,3X2VB@547|Enterobacter	1236|Gammaproteobacteria	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions	tusB	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
WLSH3_k127_1824167_29	290318.Cvib_0044	2.07e-09	63.0	COG2923@1|root,COG2923@2|Bacteria,1FF55@1090|Chlorobi	1090|Chlorobi	P	PFAM DsrE family protein	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
WLSH3_k127_1824167_33	187272.Mlg_1655	9.462e-08	59.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1WY2D@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM sulfur relay protein TusD DsrE	dsrE	GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0019417,GO:0044237,GO:0055114	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
WLSH3_k127_1824167_25	1047013.AQSP01000131_gene1807	3.052e-18	91.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295,PEMT
WLSH3_k127_1824167_16	880073.Calab_1228	1.322e-49	184.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
WLSH3_k127_1824167_28	491952.Mar181_1164	6.944e-11	66.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
WLSH3_k127_1824167_14	351160.LRC596	1.458e-52	203.0	arCOG02352@1|root,arCOG06516@1|root,arCOG02352@2157|Archaea,arCOG06516@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_1824167_7	694429.Pyrfu_0023	1.575e-67	241.0	COG0492@1|root,arCOG01296@2157|Archaea,2XPQC@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WLSH3_k127_1824167_31	416591.Tlet_0994	1.143e-08	59.0	COG0695@1|root,COG0695@2|Bacteria,2GD7W@200918|Thermotogae	200918|Thermotogae	O	glutaredoxin-like protein, YruB-family	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
WLSH3_k127_1824167_22	768672.Desfe_0703	4.281e-26	113.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WLSH3_k127_1824167_1	374847.Kcr_0072	9.963e-150	495.0	COG4231@1|root,arCOG01609@2157|Archaea	2157|Archaea	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
WLSH3_k127_1824167_20	387631.Asulf_02298	3.425e-34	139.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,246UF@183980|Archaeoglobi	183980|Archaeoglobi	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
WLSH3_k127_1824167_8	1121382.JQKG01000006_gene3528	7.731e-63	228.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WLSH3_k127_1824167_40	589924.Ferp_0202	0.0009765	48.0	arCOG00022@1|root,arCOG00022@2157|Archaea	2157|Archaea	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WLSH3_k127_1824167_38	509635.N824_02945	2.472e-05	53.0	COG0526@1|root,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1ITTM@117747|Sphingobacteriia	976|Bacteroidetes	CO	thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
WLSH3_k127_1824167_36	1033810.HLPCO_002135	5.995e-06	59.0	COG3291@1|root,COG3391@1|root,COG4886@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,2NR3W@2323|unclassified Bacteria	2|Bacteria	M	NLP P60 protein	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	CHU_C,DUF4988,PKD
WLSH3_k127_1824167_13	144197.XP_008276967.1	8.214e-55	202.0	COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,47ZN8@7711|Chordata,498TD@7742|Vertebrata,4A16Y@7898|Actinopterygii	33208|Metazoa	E	Si dkey-103j14.5	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
WLSH3_k127_1824167_9	1343739.PAP_00920	2.234e-62	225.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,244E3@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_198090_2	68170.KL590553_gene5092	1.177e-11	77.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DYIP@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
WLSH3_k127_198090_3	1449050.JNLE01000003_gene2374	0.0005272	52.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,36HI5@31979|Clostridiaceae	186801|Clostridia	O	CarboxypepD_reg-like domain	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,PPC,Peptidase_S8
WLSH3_k127_198090_1	69014.TK0499	1.993e-68	248.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,242W4@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_198090_0	1343739.PAP_02470	5.063e-121	404.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,242NX@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_198090_4	671065.MetMK1DRAFT_00011540	0.0007563	48.0	COG3276@1|root,arCOG01562@2157|Archaea,2XPZI@28889|Crenarchaeota	28889|Crenarchaeota	J	Elongation factor Tu domain 2	-	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
WLSH3_k127_2024958_2	460265.Mnod_1507	2.245e-09	70.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,1JUDI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	MA20_19540	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_2024958_5	2423.NA23_0208440	1.608e-05	58.0	COG0747@1|root,COG0747@2|Bacteria,2GC1T@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
WLSH3_k127_2024958_0	426117.M446_0671	6.012e-14	85.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,1JUDI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	MA20_19540	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_2024958_4	456442.Mboo_2377	1.799e-06	61.0	COG0747@1|root,arCOG01534@2157|Archaea	2157|Archaea	E	ABC-type dipeptide transport system periplasmic component	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_2024958_3	1380390.JIAT01000011_gene2570	2.272e-07	62.0	2AVXX@1|root,31MS0@2|Bacteria,2HQEJ@201174|Actinobacteria,4CRZD@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mg_trans_NIPA
WLSH3_k127_2024958_1	8479.XP_005309190.1	7.521e-13	78.0	KOG3780@1|root,KOG3780@2759|Eukaryota,38BDA@33154|Opisthokonta,3BA5K@33208|Metazoa,3CWWN@33213|Bilateria,4846F@7711|Chordata,48V0Q@7742|Vertebrata,4C9VZ@8459|Testudines	33208|Metazoa	S	Arrestin domain containing 1	ARRDC1	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006858,GO:0008104,GO:0008150,GO:0008152,GO:0008593,GO:0009056,GO:0009057,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0015031,GO:0015833,GO:0016020,GO:0016567,GO:0019538,GO:0019899,GO:0019941,GO:0023051,GO:0023057,GO:0030163,GO:0030674,GO:0031410,GO:0031625,GO:0031982,GO:0032446,GO:0033036,GO:0036211,GO:0042802,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043230,GO:0043412,GO:0043632,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044389,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0045746,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0051603,GO:0060090,GO:0065007,GO:0070647,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097708,GO:0140112,GO:1901564,GO:1901565,GO:1901575,GO:1903561,GO:1990756,GO:1990763	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
WLSH3_k127_2116967_4	1406840.Q763_11235	5.025e-08	55.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,2NSF4@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 3 family	bglB_4	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
WLSH3_k127_2116967_6	1236976.JCM16418_1790	7.496e-06	58.0	COG0454@1|root,COG0456@2|Bacteria,1TS4G@1239|Firmicutes,4HFDG@91061|Bacilli,26XFQ@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_2116967_0	203119.Cthe_2065	1.372e-143	471.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,3WHD2@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
WLSH3_k127_2116967_3	646529.Desaci_0971	2.576e-43	175.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,261WJ@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
WLSH3_k127_2116967_5	1336235.JAEG01000002_gene524	1.32e-06	56.0	COG1918@1|root,COG1918@2|Bacteria,1NH7U@1224|Proteobacteria,2UJG2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
WLSH3_k127_2116967_2	368408.Tpen_0976	2.181e-62	224.0	COG0370@1|root,arCOG00359@2157|Archaea,2XPKC@28889|Crenarchaeota	28889|Crenarchaeota	P	nucleoside recognition domain protein	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
WLSH3_k127_2116967_1	589924.Ferp_0446	3.087e-103	347.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,246YX@183980|Archaeoglobi	183980|Archaeoglobi	P	TIGRFAM Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
WLSH3_k127_2159646_38	523850.TON_1355	2.099e-46	192.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
WLSH3_k127_2159646_34	1459636.NTE_01198	6.321e-53	216.0	COG1404@1|root,arCOG03439@1|root,arCOG00704@2157|Archaea,arCOG03439@2157|Archaea,41SEM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
WLSH3_k127_2159646_35	635013.TherJR_1840	1.336e-51	187.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,249SD@186801|Clostridia,26212@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
WLSH3_k127_2159646_6	374847.Kcr_1548	3.261e-117	388.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
WLSH3_k127_2159646_85	456442.Mboo_1623	0.0002311	48.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
WLSH3_k127_2159646_82	456442.Mboo_1535	4.131e-05	49.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
WLSH3_k127_2159646_49	456320.Mvol_1557	2.8e-33	141.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,23QHM@183939|Methanococci	183939|Methanococci	H	PFAM Triphosphoribosyl-dephospho-CoA protein	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
WLSH3_k127_2159646_25	644282.Deba_2660	2.801e-63	225.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42R4A@68525|delta/epsilon subdivisions,2WM9Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Silent information regulator protein Sir2	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
WLSH3_k127_2159646_55	221109.22777653	5.05e-25	112.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,23KJZ@182709|Oceanobacillus	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
WLSH3_k127_2159646_1	935948.KE386493_gene2405	1.12e-241	761.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,42F10@68295|Thermoanaerobacterales	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
WLSH3_k127_2159646_17	751994.AGIG01000028_gene1630	1.819e-91	312.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
WLSH3_k127_2159646_44	477974.Daud_2132	3.761e-38	150.0	COG1751@1|root,COG1751@2|Bacteria,1V1CN@1239|Firmicutes,24G0M@186801|Clostridia,261NK@186807|Peptococcaceae	186801|Clostridia	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
WLSH3_k127_2159646_66	1385514.N782_14580	4.822e-13	74.0	COG1695@1|root,COG1695@2|Bacteria,1VA8U@1239|Firmicutes,4HKPC@91061|Bacilli,2YARZ@289201|Pontibacillus	91061|Bacilli	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
WLSH3_k127_2159646_68	1122915.AUGY01000001_gene7164	1.493e-12	80.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,4HNJ9@91061|Bacilli,26XB5@186822|Paenibacillaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_2159646_23	479434.Sthe_2788	2.562e-68	245.0	COG0006@1|root,COG0006@2|Bacteria,2G6AH@200795|Chloroflexi,27XJK@189775|Thermomicrobia	189775|Thermomicrobia	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_2159646_80	698757.Pogu_0860	1.668e-05	54.0	COG0727@1|root,arCOG02579@2157|Archaea,2XR8B@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WLSH3_k127_2159646_0	1121440.AUMA01000011_gene2309	3.024e-280	889.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
WLSH3_k127_2159646_40	1048983.EL17_19325	1.63e-43	170.0	COG2267@1|root,COG2267@2|Bacteria,4NIU9@976|Bacteroidetes,47PWX@768503|Cytophagia	976|Bacteroidetes	I	Serine aminopeptidase, S33	ytpA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WLSH3_k127_2159646_9	706587.Desti_2453	4.385e-106	351.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MQSA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
WLSH3_k127_2159646_77	1445613.JALM01000001_gene3190	5.797e-06	56.0	2ACPI@1|root,312A5@2|Bacteria,2I99C@201174|Actinobacteria,4EB1S@85010|Pseudonocardiales	201174|Actinobacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_2159646_78	697303.Thewi_2684	7.172e-06	59.0	COG0738@1|root,COG0738@2|Bacteria,1UJ6C@1239|Firmicutes,2494T@186801|Clostridia	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	ko:K18214	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.6	-	-	MFS_1
WLSH3_k127_2159646_30	634498.mru_1842	9.066e-56	204.0	COG1478@1|root,arCOG02714@2157|Archaea,2XTHI@28890|Euryarchaeota,23P1A@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
WLSH3_k127_2159646_42	351160.LRC138	8.673e-42	175.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,2N9CP@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
WLSH3_k127_2159646_16	4513.MLOC_75997.1	2.07e-95	340.0	COG1697@1|root,KOG2795@2759|Eukaryota,37QGK@33090|Viridiplantae,3G85Y@35493|Streptophyta,3KVMF@4447|Liliopsida,3I71X@38820|Poales	35493|Streptophyta	L	Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity	TOP6A	GO:0000003,GO:0000228,GO:0000280,GO:0000706,GO:0000729,GO:0001708,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0008544,GO:0009888,GO:0009913,GO:0009957,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0022402,GO:0022414,GO:0030154,GO:0030855,GO:0031974,GO:0031981,GO:0032502,GO:0033554,GO:0034641,GO:0035825,GO:0042138,GO:0042623,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045165,GO:0046483,GO:0048285,GO:0048856,GO:0048869,GO:0050896,GO:0051321,GO:0051716,GO:0060429,GO:0061505,GO:0061982,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046	-	ko:K10878	ko04113,map04113	-	-	-	ko00000,ko00001,ko03400	-	-	-	TP6A_N
WLSH3_k127_2159646_69	634498.mru_0726	6.834e-11	71.0	COG0170@1|root,COG0671@1|root,arCOG01880@2157|Archaea,arCOG07501@2157|Archaea,2XYXG@28890|Euryarchaeota,23PN8@183925|Methanobacteria	183925|Methanobacteria	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2159646_8	1343739.PAP_10275	2.065e-107	359.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
WLSH3_k127_2159646_18	273063.STK_04940	4.686e-91	316.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
WLSH3_k127_2159646_5	867903.ThesuDRAFT_00496	6.982e-126	416.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WCYT@538999|Clostridiales incertae sedis	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
WLSH3_k127_2159646_54	8479.XP_005290983.1	4.885e-25	112.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa,3CXE2@33213|Bilateria,48810@7711|Chordata,48YH9@7742|Vertebrata,4CFT3@8459|Testudines	33208|Metazoa	U	RAB18, member RAS oncogene family	RAB18	GO:0000166,GO:0001654,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006810,GO:0006887,GO:0006913,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032940,GO:0034389,GO:0035556,GO:0036094,GO:0036230,GO:0042119,GO:0042175,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098827,GO:0099503,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
WLSH3_k127_2159646_73	742823.HMPREF9465_00604	2.565e-07	58.0	COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria,4PR1M@995019|Sutterellaceae	28216|Betaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
WLSH3_k127_2159646_50	46681.XP_001737050.1	1.742e-32	134.0	KOG0079@1|root,KOG0079@2759|Eukaryota,3XFFC@554915|Amoebozoa	554915|Amoebozoa	U	Rab subfamily of small GTPases	-	-	-	-	-	-	-	-	-	-	-	-	Ras
WLSH3_k127_2159646_7	1343739.PAP_07165	6.883e-113	385.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,242YE@183968|Thermococci	183968|Thermococci	J	Phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
WLSH3_k127_2159646_11	374847.Kcr_1603	2.932e-103	353.0	COG0016@1|root,arCOG00410@2157|Archaea	2157|Archaea	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
WLSH3_k127_2159646_33	604354.TSIB_1927	7.445e-54	203.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
WLSH3_k127_2159646_60	374847.Kcr_0387	1.933e-18	93.0	arCOG03119@1|root,arCOG03119@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WLSH3_k127_2159646_14	326427.Cagg_1794	4.788e-98	332.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,374ZW@32061|Chloroflexia	32061|Chloroflexia	I	Myo-inositol-1-phosphate synthase, GAPDH domain protein	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
WLSH3_k127_2159646_22	1236689.MMALV_16610	2.046e-72	259.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota	28890|Euryarchaeota	C	reductase	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
WLSH3_k127_2159646_46	1121936.AUHI01000003_gene1776	5.002e-36	154.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli	91061|Bacilli	C	COG0277 FAD FMN-containing dehydrogenases	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iYO844.BSU28680	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_2159646_32	1267534.KB906756_gene261	3.115e-54	199.0	COG0800@1|root,COG0800@2|Bacteria,3Y4HZ@57723|Acidobacteria,2JKJ9@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
WLSH3_k127_2159646_13	1123508.JH636440_gene1975	2.952e-98	332.0	COG0524@1|root,COG0524@2|Bacteria,2IWUH@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
WLSH3_k127_2159646_2	386415.NT01CX_0498	2.133e-199	646.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
WLSH3_k127_2159646_12	1265505.ATUG01000001_gene4187	2.797e-102	346.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42NWJ@68525|delta/epsilon subdivisions,2WKW7@28221|Deltaproteobacteria,2MPSK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_2159646_86	1232443.BAIA02000077_gene254	0.0006611	48.0	2CH8U@1|root,306GF@2|Bacteria,1VDTB@1239|Firmicutes,25AZP@186801|Clostridia	186801|Clostridia	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_2159646_51	1077972.ARGLB_094_00290	1.127e-29	126.0	COG0684@1|root,COG0684@2|Bacteria,2IMPT@201174|Actinobacteria	201174|Actinobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
WLSH3_k127_2159646_56	1459636.NTE_01923	8.075e-25	106.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
WLSH3_k127_2159646_19	656519.Halsa_1020	5.402e-77	271.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,25N8F@186801|Clostridia,3WBM2@53433|Halanaerobiales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
WLSH3_k127_2159646_47	1033734.CAET01000025_gene1095	5.953e-35	150.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli,1ZCQN@1386|Bacillus	91061|Bacilli	C	Glycolate oxidase subunit	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iYO844.BSU28680	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_2159646_27	565033.GACE_1903	7.59e-63	231.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
WLSH3_k127_2159646_83	439481.Aboo_1541	0.0001259	48.0	COG1977@1|root,arCOG00536@2157|Archaea,2Y6GJ@28890|Euryarchaeota,3F3IT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
WLSH3_k127_2159646_84	1489678.RDMS_12775	0.0001281	53.0	COG1715@1|root,COG1715@2|Bacteria,1WMPN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat
WLSH3_k127_2159646_62	933801.Ahos_0100	1.782e-17	96.0	arCOG03462@1|root,arCOG03462@2157|Archaea,2XR2E@28889|Crenarchaeota	28889|Crenarchaeota	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
WLSH3_k127_2159646_10	1089553.Tph_c17120	1.693e-104	351.0	COG3535@1|root,COG3535@2|Bacteria,1TR39@1239|Firmicutes,24A65@186801|Clostridia,42FRV@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
WLSH3_k127_2159646_20	511051.CSE_05880	2.812e-76	267.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
WLSH3_k127_2159646_41	511051.CSE_05870	4.5e-42	165.0	arCOG06048@1|root,31EJQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2159646_36	1238450.VIBNISOn1_820049	8.578e-48	187.0	COG3535@1|root,COG3535@2|Bacteria,1NCBV@1224|Proteobacteria,1RQF0@1236|Gammaproteobacteria,1XVAD@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
WLSH3_k127_2159646_48	543728.Vapar_3936	4.989e-34	140.0	COG4126@1|root,COG4126@2|Bacteria,1MVNB@1224|Proteobacteria,2VIW8@28216|Betaproteobacteria,4AD4T@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Asp Glu	hyuE	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
WLSH3_k127_2159646_72	633131.TR2A62_1647	6.841e-08	62.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	tetA	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
WLSH3_k127_2159646_74	1122919.KB905616_gene200	2.86e-07	59.0	COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,4H9Q9@91061|Bacilli,26TUC@186822|Paenibacillaceae	91061|Bacilli	EGP	Multidrug transporter	mdtG	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_2159646_31	411467.BACCAP_01345	2.56e-55	206.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
WLSH3_k127_2159646_4	574087.Acear_1487	7.731e-136	454.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_2159646_45	891968.Anamo_1967	8.396e-38	147.0	COG1142@1|root,COG1142@2|Bacteria,3TCIW@508458|Synergistetes	508458|Synergistetes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2159646_71	1333523.L593_07570	6.147e-08	61.0	COG3815@1|root,arCOG03949@2157|Archaea,2XZ2C@28890|Euryarchaeota,23X0I@183963|Halobacteria	183963|Halobacteria	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
WLSH3_k127_2159646_15	272844.PAB0774	1.745e-97	331.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci	183968|Thermococci	E	Beta-eliminating lyase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
WLSH3_k127_2159646_58	419665.Maeo_1052	5.189e-22	104.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,23QN2@183939|Methanococci	183939|Methanococci	E	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
WLSH3_k127_2159646_53	997346.HMPREF9374_2024	2.081e-25	117.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,4HBYM@91061|Bacilli,27BP3@186824|Thermoactinomycetaceae	91061|Bacilli	L	endonuclease III	yfjP	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
WLSH3_k127_2159646_79	1121878.AUGL01000002_gene2250	1.628e-05	57.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type multidrug transport system, permease component	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_2159646_81	1227276.HMPREF9148_02919	3.142e-05	55.0	COG1266@1|root,COG1266@2|Bacteria,4NMMK@976|Bacteroidetes,2FP40@200643|Bacteroidia	976|Bacteroidetes	S	CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_2159646_65	1123405.AUMM01000083_gene3024	8.762e-14	85.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	-	ko:K13274,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8,SLH
WLSH3_k127_2159646_64	1298608.JCM18900_11222	2.549e-14	78.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria,3NRCW@468|Moraxellaceae	1236|Gammaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_2159646_37	368407.Memar_1663	1.378e-46	176.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
WLSH3_k127_2159646_67	5786.XP_003287618.1	1.287e-12	76.0	COG1896@1|root,KOG3197@2759|Eukaryota,3X8XM@554915|Amoebozoa	554915|Amoebozoa	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
WLSH3_k127_2159646_61	1403313.AXBR01000021_gene3037	9.288e-18	95.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,4HANH@91061|Bacilli,1ZBS3@1386|Bacillus	91061|Bacilli	S	ABC-type transport system, periplasmic component surface lipoprotein	tcsA	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
WLSH3_k127_2159646_57	243232.MJ_1398	5.533e-23	107.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_2159646_3	688269.Theth_1455	6.406e-155	509.0	COG0449@1|root,COG0449@2|Bacteria,2GBY1@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
WLSH3_k127_2159646_52	876269.ARWA01000001_gene1028	3.663e-29	128.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,3NAF4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	HJ	RimK-like ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
WLSH3_k127_2159646_63	348780.NP_4058A	4.36e-17	93.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,23T32@183963|Halobacteria	183963|Halobacteria	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2159646_70	604354.TSIB_0926	2.175e-09	61.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZIX@28890|Euryarchaeota,244GR@183968|Thermococci	183968|Thermococci	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
WLSH3_k127_2159646_24	351160.LRC208	4.699e-66	238.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_2159646_75	386456.JQKN01000001_gene1821	3.827e-07	60.0	COG1668@1|root,arCOG01462@2157|Archaea,2Y3YK@28890|Euryarchaeota	28890|Euryarchaeota	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
WLSH3_k127_2159646_28	1232410.KI421416_gene2685	2.229e-62	218.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WQX0@28221|Deltaproteobacteria,43W25@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K02617,ko:K08279	-	-	-	-	ko00000	-	-	-	Hexapep
WLSH3_k127_2159646_76	1203606.HMPREF1526_01247	1.854e-06	58.0	COG1011@1|root,COG1011@2|Bacteria,1VK8H@1239|Firmicutes	1239|Firmicutes	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	-
WLSH3_k127_2159646_21	1150474.JQJI01000005_gene277	1.006e-73	262.0	COG1251@1|root,COG1251@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	1.7.1.15	ko:K00362,ko:K02192	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2
WLSH3_k127_2159646_39	525373.HMPREF0766_11112	8.217e-46	184.0	COG0318@1|root,COG0318@2|Bacteria,4PKJY@976|Bacteroidetes,1INYG@117747|Sphingobacteriia	976|Bacteroidetes	IQ	PFAM GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
WLSH3_k127_2159646_29	387631.Asulf_01889	1.469e-59	220.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2463P@183980|Archaeoglobi	183980|Archaeoglobi	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
WLSH3_k127_2159646_43	903818.KI912269_gene538	4.14e-39	167.0	COG1199@1|root,COG1199@2|Bacteria	2|Bacteria	L	ATP-dependent helicase activity	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
WLSH3_k127_2159646_26	693661.Arcve_1842	4.33e-63	242.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,245U5@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
WLSH3_k127_2159646_59	7209.EFO20644.1	5.642e-20	102.0	COG0258@1|root,KOG2519@2759|Eukaryota,38GN8@33154|Opisthokonta,3BAYM@33208|Metazoa,3CX02@33213|Bilateria,40C19@6231|Nematoda,1KTMG@119089|Chromadorea	33208|Metazoa	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA	FEN1	GO:0000287,GO:0000723,GO:0000724,GO:0000725,GO:0000737,GO:0001654,GO:0003008,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004521,GO:0004523,GO:0004527,GO:0004529,GO:0004536,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006302,GO:0006308,GO:0006309,GO:0006310,GO:0006401,GO:0006725,GO:0006807,GO:0006915,GO:0006921,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007063,GO:0007275,GO:0007423,GO:0007610,GO:0007611,GO:0007613,GO:0008150,GO:0008152,GO:0008219,GO:0008309,GO:0008409,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009987,GO:0010564,GO:0010638,GO:0012501,GO:0016043,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016888,GO:0016891,GO:0016893,GO:0016895,GO:0017108,GO:0019439,GO:0019725,GO:0022402,GO:0022411,GO:0022616,GO:0030145,GO:0030262,GO:0031974,GO:0031981,GO:0032200,GO:0032201,GO:0032501,GO:0032502,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033260,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0042592,GO:0043010,GO:0043137,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044786,GO:0045787,GO:0045876,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0048256,GO:0048513,GO:0048518,GO:0048522,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050877,GO:0050890,GO:0050896,GO:0051128,GO:0051130,GO:0051276,GO:0051716,GO:0051726,GO:0051983,GO:0051984,GO:0060041,GO:0060249,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0071840,GO:0090068,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0097194,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576,GO:2001252	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
WLSH3_k127_2249355_38	1293054.HSACCH_01164	7.335e-08	54.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer4,Rubrerythrin
WLSH3_k127_2249355_30	5722.XP_001579002.1	1.64e-17	90.0	COG2012@1|root,KOG3218@2759|Eukaryota	2759|Eukaryota	K	DNA-directed 5'-3' RNA polymerase activity	RPB5	GO:0000418,GO:0000419,GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005730,GO:0005736,GO:0006139,GO:0006351,GO:0006360,GO:0006366,GO:0006383,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009304,GO:0009987,GO:0010467,GO:0016070,GO:0016591,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042797,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044452,GO:0044464,GO:0046483,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:0098781,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	-	ko:K03013	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb5_C,RNA_pol_Rpb5_N
WLSH3_k127_2249355_29	673860.AciM339_0624	1.57e-18	95.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y70G@28890|Euryarchaeota,3F32Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2249355_14	357808.RoseRS_1991	2.894e-53	198.0	COG1058@1|root,COG1058@2|Bacteria	2|Bacteria	S	Probable molybdopterin binding domain	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
WLSH3_k127_2249355_26	926550.CLDAP_16800	5.965e-24	110.0	COG1418@1|root,COG1418@2|Bacteria,2G9HV@200795|Chloroflexi	200795|Chloroflexi	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_2249355_17	1499967.BAYZ01000154_gene1533	3.06e-47	179.0	COG0084@1|root,COG0084@2|Bacteria,2NP9H@2323|unclassified Bacteria	2|Bacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WLSH3_k127_2249355_9	331113.SNE_A02450	1.002e-81	290.0	COG0300@1|root,COG1211@1|root,COG0300@2|Bacteria,COG1211@2|Bacteria,2JG5T@204428|Chlamydiae	2|Bacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12	ko:K00991,ko:K12506,ko:K21681	ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130	M00096	R01525,R02921,R05633,R05637	RC00002,RC00089,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,adh_short
WLSH3_k127_2249355_25	1408312.JNJS01000001_gene1363	3.739e-26	116.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,3NHQC@46205|Pseudobutyrivibrio	186801|Clostridia	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
WLSH3_k127_2249355_12	360910.BAV0089	1.621e-69	250.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	2.3.1.157,2.3.1.79,2.7.7.23	ko:K00661,ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
WLSH3_k127_2249355_27	69014.TK0891	4.5e-23	113.0	COG0438@1|root,arCOG01403@2157|Archaea,2XYCV@28890|Euryarchaeota,245MP@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_2249355_39	759914.BP951000_1254	8.729e-08	63.0	COG0463@1|root,COG0463@2|Bacteria,2J8HD@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WLSH3_k127_2249355_15	298386.PBPRA2683	1.654e-48	189.0	COG1887@1|root,COG1887@2|Bacteria,1MYNJ@1224|Proteobacteria,1SF3X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	CDP-glycerol poly(glycerophosphate) glycerophosphotransferase	-	-	2.7.8.12	ko:K09809	-	-	-	-	ko00000,ko01000	-	-	-	Glyphos_transf
WLSH3_k127_2249355_22	632245.CLP_2353	1.111e-28	125.0	COG0726@1|root,COG0726@2|Bacteria,1V6AW@1239|Firmicutes,24EU8@186801|Clostridia,36EYC@31979|Clostridiaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
WLSH3_k127_2249355_21	266748.HY04_09955	6.811e-29	129.0	COG4552@1|root,COG4552@2|Bacteria,4NKH0@976|Bacteroidetes,1HYKP@117743|Flavobacteriia	976|Bacteroidetes	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
WLSH3_k127_2249355_37	192952.MM_3219	3.675e-09	68.0	arCOG04936@1|root,arCOG04936@2157|Archaea,2XXI4@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
WLSH3_k127_2249355_11	756499.Desde_0778	4.36e-70	258.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
WLSH3_k127_2249355_18	1499967.BAYZ01000058_gene4755	1.39e-38	161.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	2.5.1.26	ko:K00803,ko:K11472	ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146	-	R00475,R04311	RC00020,RC00042,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_2249355_36	936136.ARRT01000006_gene4646	1.203e-09	66.0	COG5017@1|root,COG5017@2|Bacteria,1MZGV@1224|Proteobacteria,2UBWE@28211|Alphaproteobacteria,4BC0P@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase family 28 C-terminal domain	pssE	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
WLSH3_k127_2249355_33	1408436.JHXY01000005_gene193	5.427e-13	75.0	COG0707@1|root,COG0707@2|Bacteria,1V91X@1239|Firmicutes,24KZD@186801|Clostridia	186801|Clostridia	M	Oligosaccharide biosynthesis protein Alg14 like	-	-	-	-	-	-	-	-	-	-	-	-	Alg14
WLSH3_k127_2249355_34	457570.Nther_2371	1.837e-12	77.0	COG1305@1|root,COG4447@1|root,COG1305@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
WLSH3_k127_2249355_8	572478.Vdis_1794	1.759e-110	368.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
WLSH3_k127_2249355_41	1463934.JOCF01000085_gene619	1.606e-06	59.0	2C19R@1|root,32V2R@2|Bacteria,2GV8X@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2797)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2797
WLSH3_k127_2249355_13	667014.Thein_1052	1.443e-60	218.0	COG0535@1|root,COG0535@2|Bacteria,2GI7P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Radical_SAM
WLSH3_k127_2249355_32	224324.aq_1847	2.51e-15	80.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_2249355_10	374847.Kcr_1452	4.484e-72	257.0	COG1697@1|root,arCOG04143@2157|Archaea	2157|Archaea	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
WLSH3_k127_2249355_7	374847.Kcr_1451	1.302e-117	396.0	COG1389@1|root,arCOG01165@2157|Archaea	2157|Archaea	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
WLSH3_k127_2249355_23	1459636.NTE_00846	3.397e-27	122.0	COG1994@1|root,COG3582@1|root,arCOG00614@2157|Archaea,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
WLSH3_k127_2249355_3	289377.HL41_02015	3.138e-160	517.0	COG2509@1|root,COG2509@2|Bacteria,2GHIH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	HI0933-like protein	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,Pyr_redox_2
WLSH3_k127_2249355_31	289376.THEYE_A1498	2.173e-17	82.0	COG2509@1|root,COG2509@2|Bacteria	2|Bacteria	H	5-formyltetrahydrofolate cyclo-ligase activity	IV02_08645	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2
WLSH3_k127_2249355_42	374847.Kcr_0025	0.0001492	49.0	COG0071@1|root,arCOG01833@2157|Archaea	374847.Kcr_0025|-	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	-
WLSH3_k127_2249355_0	368408.Tpen_0679	9.799e-271	851.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPXJ@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
WLSH3_k127_2249355_4	186497.PF1497	9.814e-139	452.0	COG0436@1|root,arCOG01131@2157|Archaea,2XVXM@28890|Euryarchaeota,243JD@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
WLSH3_k127_2249355_1	562970.Btus_1413	6.296e-223	723.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9S5@91061|Bacilli,2785I@186823|Alicyclobacillaceae	91061|Bacilli	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
WLSH3_k127_2249355_20	666685.R2APBS1_3712	1.936e-29	136.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_2,Big_3_3,LTD,PKD,PPC,Pro-kuma_activ,fn3
WLSH3_k127_2249355_43	243164.DET1403	0.0006519	53.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
WLSH3_k127_2249355_24	1205680.CAKO01000035_gene316	5.333e-27	116.0	COG0454@1|root,COG0456@2|Bacteria,1N6QA@1224|Proteobacteria,2UFGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_2249355_16	1195236.CTER_0694	3.258e-48	185.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
WLSH3_k127_2249355_35	1220534.B655_1329	1.989e-11	73.0	arCOG08019@1|root,arCOG08019@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
WLSH3_k127_2249355_6	368407.Memar_2034	4.045e-125	417.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_2249355_2	1125863.JAFN01000001_gene2044	4.886e-185	597.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
WLSH3_k127_2249355_28	358681.BBR47_17150	2.512e-19	100.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,4HBTY@91061|Bacilli,26SY9@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
WLSH3_k127_2249355_5	311424.DhcVS_715	1.862e-131	436.0	COG1233@1|root,COG1233@2|Bacteria,2G5ZA@200795|Chloroflexi,34D93@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
WLSH3_k127_2249355_19	362242.MUL_3321	2.39e-34	147.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,236EE@1762|Mycobacteriaceae	201174|Actinobacteria	P	transport of arsenical compounds across the membrane (export) arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane	arsA	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
WLSH3_k127_2462079_3	1121423.JONT01000009_gene1510	1.404e-124	421.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260S3@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_2462079_37	572546.Arcpr_1245	0.0001944	45.0	arCOG04467@1|root,arCOG04467@2157|Archaea	2157|Archaea	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
WLSH3_k127_2462079_22	1123252.ATZF01000013_gene2766	1.826e-32	136.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4HBE6@91061|Bacilli,27BEA@186824|Thermoactinomycetaceae	91061|Bacilli	S	Alpha/beta hydrolase family	est	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
WLSH3_k127_2462079_15	1499967.BAYZ01000177_gene5724	8.049e-53	194.0	COG0584@1|root,COG0584@2|Bacteria,2NPNS@2323|unclassified Bacteria	2|Bacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
WLSH3_k127_2462079_20	264732.Moth_0808	1.543e-39	162.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia,42GGS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
WLSH3_k127_2462079_0	1121468.AUBR01000024_gene3021	1.889e-165	537.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_2462079_24	756499.Desde_3025	1.259e-24	110.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,262Q4@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
WLSH3_k127_2462079_27	136037.KDR21594	2.339e-11	76.0	KOG0083@1|root,KOG0083@2759|Eukaryota,38BJ8@33154|Opisthokonta,3BEFF@33208|Metazoa,3CR5I@33213|Bilateria,41UK6@6656|Arthropoda,3SGNX@50557|Insecta	33208|Metazoa	U	GTP binding. It is involved in the biological process described with protein transport	RAB37	GO:0000139,GO:0000166,GO:0000323,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002790,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005765,GO:0005766,GO:0005768,GO:0005773,GO:0005774,GO:0005793,GO:0005794,GO:0005886,GO:0006810,GO:0006887,GO:0006892,GO:0006893,GO:0006904,GO:0006955,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0008021,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0017157,GO:0019001,GO:0019002,GO:0022406,GO:0023052,GO:0030133,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031224,GO:0031226,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032940,GO:0033036,GO:0034613,GO:0035272,GO:0035556,GO:0035577,GO:0035579,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042581,GO:0042582,GO:0042886,GO:0043001,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044464,GO:0045055,GO:0045184,GO:0045202,GO:0045321,GO:0046903,GO:0048193,GO:0048278,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051179,GO:0051234,GO:0051640,GO:0051641,GO:0051716,GO:0060627,GO:0061951,GO:0065007,GO:0070382,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0072659,GO:0090150,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098588,GO:0098791,GO:0098793,GO:0098805,GO:0098852,GO:0098876,GO:0099503,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1903530,GO:1990778	-	ko:K07913,ko:K07914	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
WLSH3_k127_2462079_9	693661.Arcve_1931	2.651e-65	231.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2460M@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_2462079_36	1121926.AXWO01000047_gene1691	0.0001832	55.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4EY01@85014|Glycomycetales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_2462079_12	390874.Tpet_0568	8.411e-63	226.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_2462079_38	411489.CLOL250_00823	0.0009465	53.0	COG0577@1|root,COG0577@2|Bacteria,1TSP8@1239|Firmicutes,2481U@186801|Clostridia,36FTJ@31979|Clostridiaceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_2462079_34	1440774.Y900_021480	5.193e-06	60.0	COG0577@1|root,COG0577@2|Bacteria,2HPS0@201174|Actinobacteria,236G0@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter (permease)	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
WLSH3_k127_2462079_2	439481.Aboo_0846	1.805e-131	432.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,3F37W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	class II (D K and N)	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
WLSH3_k127_2462079_31	673860.AciM339_0292	1.083e-07	65.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03614@2157|Archaea,2XZI4@28890|Euryarchaeota	28890|Euryarchaeota	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
WLSH3_k127_2462079_19	292459.STH2797	8.511e-42	165.0	COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,25CEG@186801|Clostridia	186801|Clostridia	I	PFAM Alpha Beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WLSH3_k127_2462079_26	1282362.AEAC466_17965	7.428e-15	85.0	COG3577@1|root,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
WLSH3_k127_2462079_10	335543.Sfum_0266	2.313e-64	229.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MRCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
WLSH3_k127_2462079_25	877455.Metbo_1610	2.255e-17	88.0	COG1695@1|root,arCOG00001@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_2462079_23	1365176.N186_02405	3.887e-28	118.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
WLSH3_k127_2462079_16	877455.Metbo_0494	1.542e-47	186.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota	28890|Euryarchaeota	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
WLSH3_k127_2462079_28	439481.Aboo_1209	3.331e-10	73.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_2462079_1	1121422.AUMW01000045_gene1210	1.232e-161	530.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260YA@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
WLSH3_k127_2462079_18	1094980.Mpsy_0101	1.818e-42	164.0	COG0535@1|root,arCOG00938@2157|Archaea	2157|Archaea	P	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
WLSH3_k127_2462079_5	643648.Slip_2154	5.787e-113	385.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,42KWJ@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
WLSH3_k127_2462079_13	1365176.N186_00370	8.332e-59	216.0	COG0451@1|root,arCOG01369@2157|Archaea,2XRSX@28889|Crenarchaeota	28889|Crenarchaeota	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
WLSH3_k127_2462079_29	449447.MAE_30600	2.806e-08	66.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
WLSH3_k127_2462079_33	634498.mru_1572	3.388e-06	55.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y84Y@28890|Euryarchaeota,23P35@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
WLSH3_k127_2462079_21	871963.Desdi_1974	7.101e-36	145.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,26121@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
WLSH3_k127_2462079_4	266117.Rxyl_2848	1.508e-121	398.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4CQAT@84995|Rubrobacteria	84995|Rubrobacteria	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WLSH3_k127_2462079_17	1047013.AQSP01000055_gene265	4.142e-47	172.0	COG0251@1|root,COG0251@2|Bacteria,2NPSA@2323|unclassified Bacteria	2|Bacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
WLSH3_k127_2462079_30	767817.Desgi_0300	1e-07	64.0	COG2041@1|root,COG5492@1|root,COG2041@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	1.1.1.169,3.2.1.4,3.4.17.14	ko:K00077,ko:K01179,ko:K07260,ko:K13735	ko00500,ko00550,ko00770,ko01100,ko01110,ko01502,ko02020,ko05100,map00500,map00550,map00770,map01100,map01110,map01502,map02020,map05100	M00119,M00651	R02472,R06200,R11307,R11308	RC00726	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	GH5,GH9	-	Big_1,Big_2,Fn3_assoc,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH
WLSH3_k127_2462079_32	114615.BRADO4659	4.728e-07	59.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3JR8N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
WLSH3_k127_2462079_35	797114.C475_20233	2.251e-05	57.0	COG0206@1|root,arCOG02202@2157|Archaea,2XU3D@28890|Euryarchaeota,23SGI@183963|Halobacteria	183963|Halobacteria	D	Involved in cell shape control	cetZ2	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
WLSH3_k127_2462079_6	1265505.ATUG01000001_gene3174	3.908e-112	377.0	COG1042@1|root,COG1042@2|Bacteria,1R8Q6@1224|Proteobacteria,42NR2@68525|delta/epsilon subdivisions,2WM2A@28221|Deltaproteobacteria,2MN2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
WLSH3_k127_2462079_7	868131.MSWAN_1425	3.006e-108	363.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
WLSH3_k127_2462079_11	638303.Thal_0389	2.28e-63	223.0	COG0299@1|root,COG0299@2|Bacteria,2G3XQ@200783|Aquificae	200783|Aquificae	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
WLSH3_k127_2462079_8	360910.BAV1728	3.232e-80	284.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,3T1I7@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
WLSH3_k127_2462079_14	453591.Igni_0442	1.701e-54	198.0	COG1759@1|root,arCOG04346@2157|Archaea,2XPSG@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
WLSH3_k127_289856_0	269797.Mbar_A1789	1.245e-70	250.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
WLSH3_k127_289856_4	935948.KE386494_gene869	4.157e-48	188.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia,42GGS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
WLSH3_k127_289856_1	1122919.KB905585_gene3925	3.94e-70	250.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,4HD98@91061|Bacilli,274UM@186822|Paenibacillaceae	91061|Bacilli	EJ	Asparaginase	ansA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
WLSH3_k127_289856_7	192875.XP_004365083.1	6.601e-08	63.0	COG1100@1|root,KOG0072@2759|Eukaryota,38G98@33154|Opisthokonta	33154|Opisthokonta	U	activation of phospholipase D activity	ARL1	GO:0000045,GO:0000139,GO:0000166,GO:0001505,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006403,GO:0006605,GO:0006623,GO:0006810,GO:0006836,GO:0006886,GO:0006892,GO:0006893,GO:0006897,GO:0006914,GO:0006950,GO:0006996,GO:0007029,GO:0007030,GO:0007033,GO:0007034,GO:0007154,GO:0007267,GO:0007268,GO:0007269,GO:0007275,GO:0007431,GO:0007444,GO:0008047,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009888,GO:0009987,GO:0010256,GO:0010517,GO:0010518,GO:0012505,GO:0015031,GO:0015833,GO:0015931,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019748,GO:0019904,GO:0022607,GO:0023052,GO:0023061,GO:0030234,GO:0030334,GO:0031090,GO:0031503,GO:0031584,GO:0031984,GO:0032258,GO:0032386,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032588,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0033157,GO:0033227,GO:0033363,GO:0033365,GO:0033554,GO:0034067,GO:0034497,GO:0034613,GO:0034629,GO:0034976,GO:0035220,GO:0035272,GO:0035295,GO:0035639,GO:0036094,GO:0036465,GO:0040012,GO:0042147,GO:0042886,GO:0043001,GO:0043085,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044093,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0048193,GO:0048488,GO:0048513,GO:0048731,GO:0048732,GO:0048856,GO:0050657,GO:0050658,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051223,GO:0051234,GO:0051236,GO:0051270,GO:0051336,GO:0051345,GO:0051641,GO:0051649,GO:0051716,GO:0060191,GO:0060193,GO:0060341,GO:0060429,GO:0060627,GO:0060628,GO:0061024,GO:0061919,GO:0061951,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070727,GO:0070861,GO:0070925,GO:0071702,GO:0071705,GO:0071840,GO:0072594,GO:0072657,GO:0072659,GO:0072665,GO:0072666,GO:0090087,GO:0090150,GO:0090158,GO:0097159,GO:0097367,GO:0098588,GO:0098657,GO:0098772,GO:0098791,GO:0098876,GO:0098916,GO:0099003,GO:0099504,GO:0099536,GO:0099537,GO:0099643,GO:1901265,GO:1901363,GO:1903292,GO:1903827,GO:1905037,GO:1990778,GO:2000145	-	ko:K07942	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
WLSH3_k127_289856_5	694429.Pyrfu_1972	1.726e-42	160.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
WLSH3_k127_289856_6	273116.14324777	7.884e-41	158.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,241PV@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
WLSH3_k127_289856_3	342949.PNA2_0222	6.311e-56	198.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,243ZQ@183968|Thermococci	183968|Thermococci	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
WLSH3_k127_289856_2	1131266.ARWQ01000003_gene1579	3.369e-57	209.0	COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
WLSH3_k127_3029297_0	1365176.N186_01885	3.265e-11	66.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
WLSH3_k127_3029297_1	595494.Tola_1403	0.0005682	49.0	COG0727@1|root,COG0727@2|Bacteria,1MZPF@1224|Proteobacteria,1S8T7@1236|Gammaproteobacteria,1Y64C@135624|Aeromonadales	135624|Aeromonadales	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
WLSH3_k127_304433_4	243164.DET1403	5.04e-08	63.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
WLSH3_k127_304433_3	456442.Mboo_0647	5.169e-27	117.0	COG4741@1|root,arCOG05252@2157|Archaea	2157|Archaea	F	related to archaeal Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
WLSH3_k127_304433_2	1444309.JAQG01000017_gene776	1.371e-27	129.0	COG2866@1|root,COG2866@2|Bacteria,1UZ9X@1239|Firmicutes,4HW2F@91061|Bacilli	91061|Bacilli	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
WLSH3_k127_304433_0	926692.AZYG01000051_gene1872	6.209e-49	181.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia	186801|Clostridia	J	Acetyltransferase GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
WLSH3_k127_304433_5	221288.JH992901_gene4615	8.264e-05	50.0	2DKXX@1|root,30TW4@2|Bacteria,1G65F@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_304433_1	521045.Kole_0516	3.319e-33	132.0	2E86F@1|root,332JU@2|Bacteria,2GE79@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3089712_6	1122182.KB903814_gene2972	0.0003381	48.0	COG1378@1|root,COG1378@2|Bacteria,2H53C@201174|Actinobacteria	201174|Actinobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
WLSH3_k127_3089712_3	69014.TK0240	1.306e-45	176.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTKZ@28890|Euryarchaeota,243BY@183968|Thermococci	183968|Thermococci	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
WLSH3_k127_3089712_2	671143.DAMO_1522	1.202e-46	178.0	COG2267@1|root,COG2267@2|Bacteria,2NPTF@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	mhpC	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
WLSH3_k127_3089712_4	1123257.AUFV01000007_gene297	3.116e-24	107.0	COG4319@1|root,COG4319@2|Bacteria,1NHKV@1224|Proteobacteria,1T8CF@1236|Gammaproteobacteria,1XAF3@135614|Xanthomonadales	135614|Xanthomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
WLSH3_k127_3089712_0	880073.Calab_2418	5.563e-89	311.0	COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria	2|Bacteria	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
WLSH3_k127_3089712_5	1219084.AP014508_gene818	2.023e-19	93.0	COG1433@1|root,COG1433@2|Bacteria	2|Bacteria	S	nitrogen fixation	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
WLSH3_k127_3089712_1	373903.Hore_08800	2.427e-69	243.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,3WA6M@53433|Halanaerobiales	186801|Clostridia	S	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WLSH3_k127_3149337_3	368407.Memar_0366	8.15e-19	91.0	COG2006@1|root,arCOG02447@2157|Archaea,2XW1U@28890|Euryarchaeota,2N9D9@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_7
WLSH3_k127_3149337_1	932678.THERU_02370	1.854e-32	130.0	COG0394@1|root,COG0394@2|Bacteria,2G51E@200783|Aquificae	200783|Aquificae	T	low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
WLSH3_k127_3149337_0	1229909.NSED_07320	3.104e-104	364.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
WLSH3_k127_3149337_7	485915.Dret_1567	0.0001137	51.0	COG0457@1|root,COG2885@1|root,COG0457@2|Bacteria,COG2885@2|Bacteria,1MYZU@1224|Proteobacteria,42SNQ@68525|delta/epsilon subdivisions,2WPHI@28221|Deltaproteobacteria,2M842@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
WLSH3_k127_3149337_5	224325.AF_1479	5.376e-13	74.0	COG1487@1|root,arCOG02219@2157|Archaea,2Y1PM@28890|Euryarchaeota	28890|Euryarchaeota	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
WLSH3_k127_3149337_6	1230460.C495_08145	8.012e-06	50.0	COG1753@1|root,arCOG02681@2157|Archaea	2157|Archaea	S	Possibly the antitoxin component of a	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
WLSH3_k127_3149337_4	880073.Calab_0832	1.074e-14	86.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Cna_B,Cu_amine_oxidN1,PSII_BNR,SLH
WLSH3_k127_3149337_2	399550.Smar_1081	1.244e-27	118.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
WLSH3_k127_3197098_1	1230457.C476_04585	6.62e-25	108.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,23VIW@183963|Halobacteria	183963|Halobacteria	F	COG1437 Adenylate cyclase, class 2 (thermophilic)	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
WLSH3_k127_3197098_0	69014.TK0480	1.229e-38	155.0	COG1418@1|root,arCOG01860@2157|Archaea,2XT54@28890|Euryarchaeota,24358@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_3197098_2	439292.Bsel_0677	6.247e-13	83.0	COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,4HB2E@91061|Bacilli,26NB3@186821|Sporolactobacillaceae	91061|Bacilli	E	Transglutaminase/protease-like homologues	yebA	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
WLSH3_k127_3407337_9	439481.Aboo_1334	1.177e-09	71.0	arCOG02498@1|root,arCOG02499@1|root,arCOG02545@1|root,arCOG02498@2157|Archaea,arCOG02499@2157|Archaea,arCOG02545@2157|Archaea,2Y6YI@28890|Euryarchaeota,3F2WY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
WLSH3_k127_3407337_8	944565.HMPREF9127_0768	4.812e-15	83.0	290DM@1|root,2ZN2Z@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_3407337_3	1259795.ARJK01000003_gene895	4.293e-38	148.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WLSH3_k127_3407337_4	3218.PP1S9_169V6.1	1.235e-36	145.0	28NEG@1|root,2S3TG@2759|Eukaryota,37W4G@33090|Viridiplantae,3GXEK@35493|Streptophyta	35493|Streptophyta	S	Staygreen protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006787,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009536,GO:0009579,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010271,GO:0015994,GO:0015996,GO:0016020,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031976,GO:0031984,GO:0033013,GO:0033015,GO:0034357,GO:0034641,GO:0042440,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044248,GO:0044270,GO:0044422,GO:0044424,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0046149,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051187,GO:0051193,GO:0051195,GO:0055035,GO:0065007,GO:0071704,GO:0090056,GO:1901360,GO:1901361,GO:1901401,GO:1901402,GO:1901404,GO:1901405,GO:1901564,GO:1901565,GO:1901575,GO:1903647	4.99.1.10	ko:K22013	ko00860,ko01110,map00860,map01110	-	R08584,R09033	RC01012	ko00000,ko00001,ko01000	-	-	-	Staygreen
WLSH3_k127_3407337_7	1211814.CAPG01000021_gene776	1.225e-16	85.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,4HJMF@91061|Bacilli,1ZH6V@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_3407337_2	102129.Lepto7375DRAFT_2780	1.011e-44	168.0	COG0756@1|root,COG0756@2|Bacteria,1G5T0@1117|Cyanobacteria,1HB19@1150|Oscillatoriales	1117|Cyanobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
WLSH3_k127_3407337_5	1123288.SOV_1c12940	4.737e-35	154.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4H4M5@909932|Negativicutes	909932|Negativicutes	E	ABC transporter substrate-binding protein family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_3407337_0	342949.PNA2_0671	9.572e-145	476.0	COG3653@1|root,arCOG00690@2157|Archaea,2XVS0@28890|Euryarchaeota,2451W@183968|Thermococci	183968|Thermococci	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
WLSH3_k127_3407337_10	224325.AF_2234	5.483e-07	56.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
WLSH3_k127_3407337_1	706587.Desti_3979	6.307e-54	198.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15560	OMPdecase,Pribosyltran
WLSH3_k127_3407337_6	439481.Aboo_0134	3.563e-18	100.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
WLSH3_k127_3433825_21	410358.Mlab_0654	1.949e-13	71.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
WLSH3_k127_3433825_22	399549.Msed_2222	8.049e-12	69.0	COG2004@1|root,arCOG04182@2157|Archaea,2XR69@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
WLSH3_k127_3433825_24	604354.TSIB_0027	4.553e-09	60.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,244KC@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
WLSH3_k127_3433825_14	456320.Mvol_0001	7.907e-55	199.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,23Q1F@183939|Methanococci	183939|Methanococci	K	RNA binding S1 domain protein	-	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
WLSH3_k127_3433825_19	391623.TERMP_02010	6.552e-20	94.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
WLSH3_k127_3433825_0	402880.MmarC5_0382	9.702e-148	478.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
WLSH3_k127_3433825_18	647113.Metok_0012	2.358e-33	132.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23R2F@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
WLSH3_k127_3433825_17	1042877.GQS_06845	7.697e-50	192.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
WLSH3_k127_3433825_8	342949.PNA2_0268	7.491e-72	253.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
WLSH3_k127_3433825_13	70601.3256392	2.757e-57	207.0	COG2413@1|root,arCOG04066@2157|Archaea,2XSZH@28890|Euryarchaeota,24347@183968|Thermococci	183968|Thermococci	S	Nucleotidyltransferase domain	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
WLSH3_k127_3433825_5	1236689.MMALV_16390	2.607e-81	284.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
WLSH3_k127_3433825_9	593117.TGAM_1098	6.296e-70	250.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
WLSH3_k127_3433825_2	1236689.MMALV_09880	3.476e-102	349.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,3F2HJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	AAA domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
WLSH3_k127_3433825_1	529709.PYCH_02180	1.203e-110	372.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
WLSH3_k127_3433825_7	273063.STK_14190	5.037e-73	256.0	COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota	28889|Crenarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WLSH3_k127_3433825_11	573063.Metin_0981	1.854e-65	234.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,23Q49@183939|Methanococci	183939|Methanococci	J	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WLSH3_k127_3433825_25	933801.Ahos_0590	2.439e-05	51.0	arCOG03770@1|root,arCOG03770@2157|Archaea	2157|Archaea	M	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3433825_3	374847.Kcr_1153	8.613e-86	297.0	COG4046@1|root,arCOG04181@2157|Archaea	2157|Archaea	S	DUF1512 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
WLSH3_k127_3433825_15	439481.Aboo_0956	1.988e-50	189.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,3F2N8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
WLSH3_k127_3433825_16	604354.TSIB_1196	4.152e-50	190.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,242IM@183968|Thermococci	183968|Thermococci	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
WLSH3_k127_3433825_23	246969.TAM4_1418	3.938e-09	64.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota,244BU@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
WLSH3_k127_3433825_10	9365.XP_007538934.1	7.676e-66	232.0	COG1889@1|root,KOG1596@2759|Eukaryota,38EYU@33154|Opisthokonta,3BCKB@33208|Metazoa,3CXRH@33213|Bilateria,480X2@7711|Chordata,48VH0@7742|Vertebrata,3JDNQ@40674|Mammalia	33208|Metazoa	A	box C/D snoRNA 3'-end processing	FBL	GO:0000154,GO:0000494,GO:0001085,GO:0001091,GO:0001094,GO:0001098,GO:0001099,GO:0001510,GO:0001650,GO:0001651,GO:0001652,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005732,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006403,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008134,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0015030,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016604,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0019899,GO:0022613,GO:0030532,GO:0030684,GO:0031123,GO:0031126,GO:0031167,GO:0031428,GO:0031974,GO:0031981,GO:0032040,GO:0032259,GO:0032991,GO:0033036,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044452,GO:0044464,GO:0046483,GO:0048254,GO:0051117,GO:0051179,GO:0051276,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0120114,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259,GO:1990904	-	ko:K14563	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	Fibrillarin
WLSH3_k127_3433825_4	694429.Pyrfu_1810	1.572e-83	293.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
WLSH3_k127_3433825_6	1041930.Mtc_1012	2.504e-80	277.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
WLSH3_k127_3433825_12	243232.MJ_1446	9.191e-58	211.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,23QKQ@183939|Methanococci	183939|Methanococci	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
WLSH3_k127_3433825_20	885580.XP_010611769.1	8.006e-15	86.0	COG4886@1|root,KOG0619@2759|Eukaryota,38CAQ@33154|Opisthokonta,3BIGC@33208|Metazoa,3CZHW@33213|Bilateria,481FX@7711|Chordata,48V0V@7742|Vertebrata,3J8N7@40674|Mammalia,35NF5@314146|Euarchontoglires,4PYRB@9989|Rodentia	33208|Metazoa	T	Podocan-like protein 1	PODNL1	GO:0001932,GO:0001933,GO:0003674,GO:0004857,GO:0004860,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006469,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0019207,GO:0019210,GO:0019220,GO:0019221,GO:0019222,GO:0019887,GO:0023051,GO:0023052,GO:0023057,GO:0030234,GO:0031012,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0034097,GO:0042221,GO:0042325,GO:0042326,GO:0043086,GO:0043549,GO:0044092,GO:0044421,GO:0044424,GO:0044464,GO:0045859,GO:0045936,GO:0046425,GO:0046426,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071310,GO:0071345,GO:0080090,GO:0098772,GO:1902531,GO:1902532,GO:1904892,GO:1904893	-	-	-	-	-	-	-	-	-	-	LRR_1,LRR_4,LRR_6,LRR_8
WLSH3_k127_3473337_0	387631.Asulf_00227	1.613e-36	145.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2466I@183980|Archaeoglobi	183980|Archaeoglobi	F	thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
WLSH3_k127_3482312_1	756499.Desde_0778	5.493e-92	316.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
WLSH3_k127_3482312_2	888816.HMPREF9389_1488	9.77e-86	294.0	COG0596@1|root,COG0596@2|Bacteria,1V055@1239|Firmicutes,4HGD3@91061|Bacilli	91061|Bacilli	S	Hydrolase, alpha beta domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
WLSH3_k127_3482312_5	70601.3257235	1.401e-05	55.0	COG1510@1|root,arCOG02795@2157|Archaea,2Y3PA@28890|Euryarchaeota,2441A@183968|Thermococci	183968|Thermococci	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
WLSH3_k127_3482312_4	768671.ThimaDRAFT_1264	1.001e-19	106.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Chlam_PMP
WLSH3_k127_3482312_0	1094980.Mpsy_3151	2.138e-126	448.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3482312_3	521011.Mpal_1421	2.526e-20	108.0	COG3291@1|root,COG3391@1|root,arCOG02508@2157|Archaea,arCOG03563@2157|Archaea,2Y2RX@28890|Euryarchaeota,2NAHT@224756|Methanomicrobia	224756|Methanomicrobia	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,PKD
WLSH3_k127_3504266_0	203275.BFO_1601	2.603e-25	115.0	2DPHF@1|root,33237@2|Bacteria,4P0MC@976|Bacteroidetes,2FZZF@200643|Bacteroidia	976|Bacteroidetes	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
WLSH3_k127_3504266_4	272562.CA_C2026	3.742e-05	53.0	COG0716@1|root,COG0716@2|Bacteria,1VK0S@1239|Firmicutes,24QS1@186801|Clostridia,36KWV@31979|Clostridiaceae	186801|Clostridia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
WLSH3_k127_3504266_2	386456.JQKN01000001_gene1958	4.06e-21	100.0	arCOG09739@1|root,arCOG09739@2157|Archaea,2Y5GY@28890|Euryarchaeota,23PVA@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
WLSH3_k127_3504266_3	1463885.KL578430_gene6947	3.463e-15	81.0	COG1670@1|root,COG1670@2|Bacteria,2HE22@201174|Actinobacteria	201174|Actinobacteria	J	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
WLSH3_k127_3504266_1	1123288.SOV_5c01120	4.226e-24	109.0	COG2020@1|root,COG2020@2|Bacteria,1V495@1239|Firmicutes	1239|Firmicutes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_3548700_6	1227500.C494_14468	2.697e-06	53.0	COG2452@1|root,arCOG03164@2157|Archaea,2XW65@28890|Euryarchaeota,23ZC4@183963|Halobacteria	183963|Halobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Resolvase
WLSH3_k127_3548700_4	1286171.EAL2_808p04200	1.19e-09	60.0	COG2452@1|root,COG2452@2|Bacteria,1V0VS@1239|Firmicutes,24EGI@186801|Clostridia	186801|Clostridia	L	regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1,Resolvase
WLSH3_k127_3548700_5	868131.MSWAN_1444	2.6e-06	52.0	COG2174@1|root,arCOG04168@2157|Archaea,2Y0IH@28890|Euryarchaeota,23PPB@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eL34 family	rpl34e	-	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
WLSH3_k127_3548700_2	243232.MJ_0656	2.225e-41	158.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,23QTJ@183939|Methanococci	183939|Methanococci	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
WLSH3_k127_3548700_3	1365176.N186_03270	3.377e-30	122.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
WLSH3_k127_3548700_0	269797.Mbar_A0082	1.334e-116	384.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
WLSH3_k127_3548700_1	386456.JQKN01000001_gene2093	7.262e-42	158.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,23P0G@183925|Methanobacteria	183925|Methanobacteria	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
WLSH3_k127_3680908_13	883.DvMF_0785	1.459e-08	61.0	2E8UW@1|root,3335A@2|Bacteria,1N8I8@1224|Proteobacteria,42WSF@68525|delta/epsilon subdivisions,2WRK4@28221|Deltaproteobacteria,2ME1R@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_3680908_1	1266925.JHVX01000001_gene2544	2.758e-170	553.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,372T7@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Alpha-amylase domain	aglA	-	3.2.1.10,3.2.1.20	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01718,R01791,R06087,R06088,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
WLSH3_k127_3680908_3	391623.TERMP_01370	3.719e-67	237.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
WLSH3_k127_3680908_2	272844.PAB1498	2.219e-99	334.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
WLSH3_k127_3680908_5	639282.DEFDS_0486	1.165e-58	207.0	COG2131@1|root,COG2131@2|Bacteria,2GFK7@200930|Deferribacteres	200930|Deferribacteres	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
WLSH3_k127_3680908_11	439481.Aboo_1413	1.122e-14	78.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68Y@28890|Euryarchaeota,3F2VA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
WLSH3_k127_3680908_12	186497.PF1791	1.351e-13	73.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,244GS@183968|Thermococci	183968|Thermococci	J	H ACA RNA-protein complex	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
WLSH3_k127_3680908_14	1163730.FFONT_1223	0.0004003	48.0	COG1522@1|root,arCOG04153@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	rpc34	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC,HTH_24,MarR
WLSH3_k127_3680908_7	565033.GACE_0647	2.288e-43	165.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,245SF@183980|Archaeoglobi	183980|Archaeoglobi	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
WLSH3_k127_3680908_4	339860.Msp_0291	9.303e-63	233.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
WLSH3_k127_3680908_6	1185876.BN8_04452	1.559e-52	189.0	COG0652@1|root,COG0652@2|Bacteria,4NKQ7@976|Bacteroidetes,47P72@768503|Cytophagia	976|Bacteroidetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
WLSH3_k127_3680908_10	192952.MM_1555	1.329e-38	152.0	COG2220@1|root,arCOG00497@2157|Archaea,2XUPM@28890|Euryarchaeota,2NATF@224756|Methanomicrobia	224756|Methanomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
WLSH3_k127_3680908_9	1128421.JAGA01000003_gene2815	9.737e-41	162.0	COG1082@1|root,COG1082@2|Bacteria,2NRRT@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_3680908_0	880073.Calab_1785	1.929e-282	885.0	COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	selD	-	2.7.9.3,2.8.1.7	ko:K01008,ko:K04487	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03595,R07460,R11528,R11529	RC00002,RC01789,RC02313,RC02878	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	AIRS,AIRS_C,Aminotran_5
WLSH3_k127_3680908_8	1541960.KQ78_01428	2.632e-42	161.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
WLSH3_k127_3722054_2	479433.Caci_4827	7.839e-27	121.0	COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
WLSH3_k127_3722054_0	693661.Arcve_1188	3.326e-127	421.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,246NW@183980|Archaeoglobi	183980|Archaeoglobi	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WLSH3_k127_3722054_1	935948.KE386495_gene1235	7.612e-99	335.0	COG0438@1|root,COG0438@2|Bacteria,1TQRQ@1239|Firmicutes,249H2@186801|Clostridia,42EVC@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_3722054_3	608506.COB47_0960	2.945e-12	68.0	COG1331@1|root,COG1331@2|Bacteria,1TSDQ@1239|Firmicutes,24C1Y@186801|Clostridia,42F8J@68295|Thermoanaerobacterales	186801|Clostridia	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4004661_13	1444309.JAQG01000073_gene305	6.568e-49	201.0	COG0454@1|root,COG0456@2|Bacteria,1TQQA@1239|Firmicutes,4HBXN@91061|Bacilli,26RQ4@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
WLSH3_k127_4004661_15	1089552.KI911559_gene541	3.765e-44	168.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,2JRV2@204441|Rhodospirillales	204441|Rhodospirillales	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
WLSH3_k127_4004661_19	351160.LRC318	4.212e-26	126.0	COG2202@1|root,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_4004661_11	439235.Dalk_2834	2.124e-69	253.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,43B2Q@68525|delta/epsilon subdivisions,2WK38@28221|Deltaproteobacteria,2MJTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_4004661_10	565033.GACE_1903	2.055e-81	284.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
WLSH3_k127_4004661_16	521045.Kole_0126	8.977e-42	163.0	COG0765@1|root,COG0765@2|Bacteria,2GCAY@200918|Thermotogae	200918|Thermotogae	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
WLSH3_k127_4004661_9	634497.HAH_2280	6.188e-82	280.0	COG1126@1|root,arCOG00923@2157|Archaea,2XVB5@28890|Euryarchaeota,23SDF@183963|Halobacteria	183963|Halobacteria	E	COG1126 ABC-type polar amino acid transport system, ATPase component	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
WLSH3_k127_4004661_18	570952.ATVH01000001_gene898	1.226e-35	144.0	COG0765@1|root,COG0765@2|Bacteria,1N786@1224|Proteobacteria,2TRW3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0765 ABC-type amino acid transport system permease component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
WLSH3_k127_4004661_20	2423.NA23_0210595	6.301e-22	105.0	COG0834@1|root,COG0834@2|Bacteria,2GC3G@200918|Thermotogae	200918|Thermotogae	ET	PFAM extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
WLSH3_k127_4004661_22	768706.Desor_0860	2.031e-12	69.0	COG1146@1|root,COG1146@2|Bacteria,1W2AI@1239|Firmicutes,25709@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
WLSH3_k127_4004661_14	1121468.AUBR01000028_gene1506	1.34e-46	179.0	COG1149@1|root,COG1149@2|Bacteria,1VDSQ@1239|Firmicutes,24NTS@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_4004661_4	304371.MCP_0970	2.009e-120	402.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
WLSH3_k127_4004661_3	706587.Desti_3732	3.148e-144	467.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42PRI@68525|delta/epsilon subdivisions,2X5GA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
WLSH3_k127_4004661_2	342949.PNA2_1352	1.102e-180	585.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,242P8@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
WLSH3_k127_4004661_7	1379698.RBG1_1C00001G0675	1.247e-104	351.0	COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lysDH	-	1.4.1.18	ko:K19064	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R00446,R02317	RC00062,RC00694	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
WLSH3_k127_4004661_5	572479.Hprae_0073	2.314e-120	399.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,3WBDU@53433|Halanaerobiales	186801|Clostridia	E	threonine ammonia-lyase, biosynthetic, long form	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
WLSH3_k127_4004661_23	329726.AM1_1443	1.262e-06	61.0	COG1073@1|root,COG1073@2|Bacteria,1G1MU@1117|Cyanobacteria	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WLSH3_k127_4004661_6	1047013.AQSP01000059_gene2098	1.018e-116	383.0	COG0451@1|root,COG0451@2|Bacteria,2NQD6@2323|unclassified Bacteria	2|Bacteria	GM	RmlD substrate binding domain	ltd	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase
WLSH3_k127_4004661_0	1304885.AUEY01000101_gene2140	0.0	1150.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
WLSH3_k127_4004661_1	580340.Tlie_1732	1.867e-225	707.0	COG0031@1|root,COG0031@2|Bacteria,3T9XD@508458|Synergistetes	508458|Synergistetes	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	PALP
WLSH3_k127_4004661_25	1313421.JHBV01000030_gene2160	0.000417	54.0	COG1572@1|root,COG2911@1|root,COG2931@1|root,COG3391@1|root,COG3897@1|root,COG1572@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG3897@2|Bacteria,4PN0F@976|Bacteroidetes,1IWTM@117747|Sphingobacteriia	976|Bacteroidetes	P	major pilin protein fima	-	-	-	-	-	-	-	-	-	-	-	-	LTD,Laminin_G_3
WLSH3_k127_4004661_12	523845.AQXV01000048_gene613	9.153e-67	248.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,23QKV@183939|Methanococci	183939|Methanococci	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
WLSH3_k127_4004661_8	157072.XP_008873065.1	8.73e-104	348.0	COG0162@1|root,KOG2144@2759|Eukaryota	2759|Eukaryota	J	tyrosine-tRNA ligase activity	YARS	GO:0000049,GO:0001664,GO:0002181,GO:0002682,GO:0002685,GO:0002688,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004831,GO:0005102,GO:0005126,GO:0005153,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0006915,GO:0006935,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009605,GO:0009966,GO:0009987,GO:0010467,GO:0010469,GO:0010494,GO:0010646,GO:0010758,GO:0012501,GO:0016070,GO:0016604,GO:0016874,GO:0016875,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0023051,GO:0030334,GO:0030545,GO:0031974,GO:0031981,GO:0032101,GO:0032879,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034660,GO:0035770,GO:0036464,GO:0040011,GO:0040012,GO:0042056,GO:0042221,GO:0042330,GO:0042379,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045236,GO:0046483,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050918,GO:0050920,GO:0051270,GO:0051716,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1905521,GO:1990904,GO:2000145	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iMM904.YGR185C,iND750.YGR185C	tRNA-synt_1b,tRNA_bind
WLSH3_k127_4004661_17	635013.TherJR_2836	9.682e-40	162.0	COG0392@1|root,COG0392@2|Bacteria,1VD4Q@1239|Firmicutes,24XDX@186801|Clostridia,263AA@186807|Peptococcaceae	186801|Clostridia	S	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
WLSH3_k127_4004661_21	1197130.BAFM01000016_gene2569	3.374e-18	93.0	COG0613@1|root,arCOG00302@2157|Archaea,2XT0K@28890|Euryarchaeota,23TRI@183963|Halobacteria	183963|Halobacteria	S	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
WLSH3_k127_4006326_1	36875.HQ29_08145	1.214e-38	166.0	COG1470@1|root,COG1470@2|Bacteria,4P0GS@976|Bacteroidetes	976|Bacteroidetes	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4006326_2	935866.JAER01000003_gene1293	0.0009511	52.0	COG4932@1|root,COG4932@2|Bacteria,2I2ZN@201174|Actinobacteria	201174|Actinobacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
WLSH3_k127_4006326_0	926550.CLDAP_23540	6.499e-193	613.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
WLSH3_k127_4112124_2	429009.Adeg_1087	2.45e-19	91.0	COG1433@1|root,COG1433@2|Bacteria,1VFDZ@1239|Firmicutes,24R8N@186801|Clostridia,42GPN@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
WLSH3_k127_4112124_3	498761.HM1_0830	1.141e-07	58.0	COG1433@1|root,COG1433@2|Bacteria	2|Bacteria	S	nitrogen fixation	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
WLSH3_k127_4112124_0	69014.TK0703	2.823e-125	411.0	COG0731@1|root,arCOG00953@2157|Archaea,2XUIN@28890|Euryarchaeota,243IU@183968|Thermococci	183968|Thermococci	J	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_4112124_1	105559.Nwat_1538	3.415e-23	101.0	COG1018@1|root,COG1018@2|Bacteria,1R5YD@1224|Proteobacteria,1T2RI@1236|Gammaproteobacteria,1WY0W@135613|Chromatiales	135613|Chromatiales	C	PFAM Oxidoreductase FAD NAD(P)-binding	-	-	1.6.2.2	ko:K00326	ko00520,map00520	-	R00100	-	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
WLSH3_k127_4250854_6	572478.Vdis_0095	3.137e-34	138.0	COG0663@1|root,arCOG01849@2157|Archaea,2XS10@28889|Crenarchaeota	28889|Crenarchaeota	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WLSH3_k127_4250854_11	345341.KUTG_03079	1.158e-05	53.0	COG1764@1|root,COG1764@2|Bacteria,2IHT2@201174|Actinobacteria,4E3XW@85010|Pseudonocardiales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
WLSH3_k127_4250854_8	1122604.JONR01000022_gene671	1.478e-20	100.0	2CD6U@1|root,32RX5@2|Bacteria,1N8DY@1224|Proteobacteria,1SF31@1236|Gammaproteobacteria,1X8KS@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4250854_7	694429.Pyrfu_1090	1.484e-23	110.0	COG2220@1|root,arCOG00497@2157|Archaea,2XQFG@28889|Crenarchaeota	28889|Crenarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
WLSH3_k127_4250854_1	500153.JOEK01000009_gene5062	2.155e-93	314.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
WLSH3_k127_4250854_4	1123393.KB891316_gene1463	1.236e-44	164.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,1KRW4@119069|Hydrogenophilales	119069|Hydrogenophilales	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
WLSH3_k127_4250854_0	1449126.JQKL01000015_gene2922	9.403e-136	448.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,267XC@186813|unclassified Clostridiales	186801|Clostridia	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
WLSH3_k127_4250854_5	208439.AJAP_13905	3.279e-44	177.0	COG4990@1|root,COG4990@2|Bacteria,2GQ07@201174|Actinobacteria,4DXNX@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
WLSH3_k127_4250854_9	911045.PSE_0026	1.627e-14	82.0	COG1695@1|root,COG1695@2|Bacteria,1RCMM@1224|Proteobacteria,2U5TC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_4250854_12	5888.CAK71390	0.0001942	53.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
WLSH3_k127_4250854_2	1123277.KB893181_gene2301	4.34e-82	281.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.23	ko:K01054	ko00561,ko01100,ko04714,ko04723,ko04923,map00561,map01100,map04714,map04723,map04923	M00098	R01351	RC00020,RC00041	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Hydrolase_4
WLSH3_k127_4250854_3	1220534.B655_1031	1.702e-63	228.0	COG0348@1|root,arCOG02772@2157|Archaea,2Y033@28890|Euryarchaeota,23PTT@183925|Methanobacteria	183925|Methanobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
WLSH3_k127_4250854_10	671143.DAMO_1946	7.009e-13	79.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
WLSH3_k127_4272966_75	693661.Arcve_1145	1.52e-20	100.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,245SX@183980|Archaeoglobi	183980|Archaeoglobi	E	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
WLSH3_k127_4272966_62	373903.Hore_04870	1.214e-36	149.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,3WAJM@53433|Halanaerobiales	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
WLSH3_k127_4272966_78	7994.ENSAMXP00000011382	1.508e-16	90.0	KOG0443@1|root,KOG0443@2759|Eukaryota,38BDF@33154|Opisthokonta,3B9RZ@33208|Metazoa,3CVSD@33213|Bilateria,483GQ@7711|Chordata,494JV@7742|Vertebrata,49SUD@7898|Actinopterygii	33208|Metazoa	Z	Scinderin	SCIN	GO:0001786,GO:0002682,GO:0002684,GO:0003674,GO:0003779,GO:0005488,GO:0005509,GO:0005515,GO:0005543,GO:0005545,GO:0005546,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005903,GO:0005938,GO:0006810,GO:0006887,GO:0006996,GO:0007010,GO:0007015,GO:0008064,GO:0008092,GO:0008104,GO:0008150,GO:0008285,GO:0008289,GO:0009987,GO:0010638,GO:0010639,GO:0010941,GO:0010942,GO:0016020,GO:0016043,GO:0016192,GO:0017156,GO:0030029,GO:0030036,GO:0030832,GO:0030833,GO:0030834,GO:0030835,GO:0030837,GO:0030838,GO:0031333,GO:0031334,GO:0032271,GO:0032272,GO:0032273,GO:0032330,GO:0032507,GO:0032535,GO:0032879,GO:0032940,GO:0032956,GO:0032970,GO:0032991,GO:0033036,GO:0033043,GO:0034613,GO:0035091,GO:0042127,GO:0042981,GO:0042989,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043169,GO:0043242,GO:0043244,GO:0043254,GO:0044087,GO:0044089,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045010,GO:0045055,GO:0045185,GO:0045595,GO:0045597,GO:0045637,GO:0045639,GO:0045652,GO:0045654,GO:0046872,GO:0046903,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051014,GO:0051015,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051094,GO:0051125,GO:0051127,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051493,GO:0051494,GO:0051495,GO:0051641,GO:0051651,GO:0051693,GO:0061035,GO:0065007,GO:0065008,GO:0070727,GO:0071840,GO:0071944,GO:0072341,GO:0090066,GO:0097435,GO:0098862,GO:0099568,GO:0110053,GO:1901879,GO:1901880,GO:1901981,GO:1902903,GO:1902904,GO:1902905,GO:1902936,GO:1903706,GO:1903708,GO:2000026	-	ko:K05761,ko:K05768,ko:K08017	ko04666,ko04810,ko05203,map04666,map04810,map05203	-	-	-	ko00000,ko00001,ko04147,ko04812	-	-	-	Gelsolin
WLSH3_k127_4272966_39	593750.Metfor_2676	2.224e-66	238.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
WLSH3_k127_4272966_31	335543.Sfum_3864	4.703e-75	265.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ldpA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,LdpA_C
WLSH3_k127_4272966_9	368408.Tpen_1350	4.172e-193	613.0	COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota	28889|Crenarchaeota	E	carboxypeptidase activity	-	-	-	ko:K12941,ko:K13048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_4272966_92	1047013.AQSP01000131_gene1811	1.847e-09	69.0	COG2006@1|root,COG2768@1|root,COG2006@2|Bacteria,COG2768@2|Bacteria,2NPTK@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_6
WLSH3_k127_4272966_20	1094980.Mpsy_2655	9.57e-124	409.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
WLSH3_k127_4272966_13	4932.YFL039C	7.031e-154	494.0	COG5277@1|root,KOG0676@2759|Eukaryota,38C0D@33154|Opisthokonta,3NWC7@4751|Fungi,3QK5Q@4890|Ascomycota,3RRX1@4891|Saccharomycetes,3RYD3@4893|Saccharomycetaceae	4751|Fungi	Z	Belongs to the actin family	ACT1	GO:0000001,GO:0000003,GO:0000011,GO:0000123,GO:0000132,GO:0000142,GO:0000226,GO:0000228,GO:0000278,GO:0000281,GO:0000785,GO:0000790,GO:0000812,GO:0000910,GO:0000912,GO:0000915,GO:0000916,GO:0001300,GO:0001411,GO:0002790,GO:0003006,GO:0003674,GO:0005198,GO:0005200,GO:0005575,GO:0005622,GO:0005623,GO:0005628,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005826,GO:0005829,GO:0005856,GO:0005884,GO:0005933,GO:0005935,GO:0005937,GO:0005938,GO:0006139,GO:0006259,GO:0006281,GO:0006325,GO:0006338,GO:0006464,GO:0006473,GO:0006475,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006897,GO:0006928,GO:0006950,GO:0006974,GO:0006979,GO:0006996,GO:0007005,GO:0007010,GO:0007017,GO:0007033,GO:0007049,GO:0007114,GO:0007117,GO:0007119,GO:0007163,GO:0007568,GO:0007569,GO:0008104,GO:0008150,GO:0008152,GO:0008360,GO:0009272,GO:0009306,GO:0009653,GO:0009987,GO:0010927,GO:0015031,GO:0015629,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016569,GO:0016570,GO:0016573,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0019953,GO:0019954,GO:0022402,GO:0022413,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0030010,GO:0030029,GO:0030036,GO:0030048,GO:0030050,GO:0030154,GO:0030427,GO:0030435,GO:0030437,GO:0030476,GO:0030479,GO:0030705,GO:0030863,GO:0030864,GO:0030865,GO:0030866,GO:0031011,GO:0031032,GO:0031248,GO:0031505,GO:0031974,GO:0031981,GO:0032153,GO:0032155,GO:0032432,GO:0032502,GO:0032505,GO:0032506,GO:0032940,GO:0032989,GO:0032991,GO:0033036,GO:0033202,GO:0033554,GO:0034293,GO:0034599,GO:0034641,GO:0034728,GO:0035267,GO:0036211,GO:0036213,GO:0040001,GO:0040007,GO:0042221,GO:0042244,GO:0042546,GO:0042763,GO:0042764,GO:0042886,GO:0042995,GO:0043044,GO:0043170,GO:0043189,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043332,GO:0043412,GO:0043486,GO:0043543,GO:0043933,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044451,GO:0044454,GO:0044463,GO:0044464,GO:0044703,GO:0044837,GO:0045184,GO:0045229,GO:0046483,GO:0046903,GO:0046907,GO:0048308,GO:0048311,GO:0048468,GO:0048471,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051179,GO:0051234,GO:0051276,GO:0051286,GO:0051293,GO:0051294,GO:0051301,GO:0051321,GO:0051640,GO:0051641,GO:0051646,GO:0051648,GO:0051649,GO:0051650,GO:0051653,GO:0051656,GO:0051704,GO:0051716,GO:0060303,GO:0061640,GO:0061645,GO:0065007,GO:0065008,GO:0070013,GO:0070590,GO:0070591,GO:0070603,GO:0070726,GO:0070887,GO:0070938,GO:0071554,GO:0071555,GO:0071702,GO:0071704,GO:0071705,GO:0071824,GO:0071840,GO:0071852,GO:0071940,GO:0071944,GO:0071963,GO:0090304,GO:0097346,GO:0098657,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0099515,GO:0099518,GO:0099568,GO:0110085,GO:0120025,GO:0120038,GO:0120104,GO:0120105,GO:0120106,GO:1901360,GO:1901564,GO:1902407,GO:1902410,GO:1902493,GO:1902494,GO:1902562,GO:1902850,GO:1903046,GO:1903047,GO:1903475,GO:1904949,GO:1990234	-	ko:K05692	ko04015,ko04145,ko04210,ko04390,ko04391,ko04510,ko04520,ko04530,ko04611,ko04670,ko04714,ko04745,ko04810,ko04919,ko04921,ko05100,ko05110,ko05130,ko05131,ko05132,ko05164,ko05205,ko05225,ko05410,ko05412,ko05414,ko05416,ko05418,map04015,map04145,map04210,map04390,map04391,map04510,map04520,map04530,map04611,map04670,map04714,map04745,map04810,map04919,map04921,map05100,map05110,map05130,map05131,map05132,map05164,map05205,map05225,map05410,map05412,map05414,map05416,map05418	-	-	-	ko00000,ko00001,ko03019,ko03021,ko03029,ko03036,ko04147,ko04812	-	-	-	Actin
WLSH3_k127_4272966_63	368407.Memar_1710	1.603e-34	141.0	COG0571@1|root,arCOG03457@2157|Archaea	368407.Memar_1710|-	K	PFAM Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4272966_55	1343739.PAP_07770	9.492e-46	184.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2433G@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_4272966_103	400682.PAC_15702037	9.335e-05	54.0	2CN78@1|root,2QUBC@2759|Eukaryota,39REQ@33154|Opisthokonta,3BATP@33208|Metazoa	33208|Metazoa	S	germinal center B cell differentiation	ITFG2	GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002285,GO:0002312,GO:0002313,GO:0002314,GO:0002335,GO:0002366,GO:0002376,GO:0002520,GO:0002521,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005765,GO:0005773,GO:0005774,GO:0005829,GO:0006950,GO:0006955,GO:0007154,GO:0007275,GO:0008150,GO:0009267,GO:0009605,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010646,GO:0010648,GO:0016020,GO:0023051,GO:0023057,GO:0030097,GO:0030098,GO:0030154,GO:0030183,GO:0031090,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032006,GO:0032007,GO:0032501,GO:0032502,GO:0032991,GO:0033554,GO:0034198,GO:0042113,GO:0042149,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045321,GO:0046649,GO:0048513,GO:0048519,GO:0048523,GO:0048534,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070013,GO:0071496,GO:0098588,GO:0098805,GO:0098852,GO:0140007,GO:1902531,GO:1902532,GO:1903432,GO:1904262,GO:1990928	-	-	-	-	-	-	-	-	-	-	Itfg2
WLSH3_k127_4272966_82	42256.RradSPS_0259	3.627e-16	86.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CQHA@84995|Rubrobacteria	84995|Rubrobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
WLSH3_k127_4272966_76	552811.Dehly_0584	5.408e-19	100.0	COG1208@1|root,COG1208@2|Bacteria,2GAPW@200795|Chloroflexi,34D0H@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
WLSH3_k127_4272966_61	309801.trd_0428	6.445e-37	148.0	COG0009@1|root,COG0009@2|Bacteria,2G673@200795|Chloroflexi,27Y7A@189775|Thermomicrobia	189775|Thermomicrobia	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
WLSH3_k127_4272966_79	178306.PAE2935	1.521e-16	87.0	COG1818@1|root,arCOG00084@2157|Archaea	2157|Archaea	J	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
WLSH3_k127_4272966_95	693661.Arcve_2000	1.625e-08	63.0	COG1617@1|root,arCOG02197@2157|Archaea,2Y6GS@28890|Euryarchaeota,246DJ@183980|Archaeoglobi	183980|Archaeoglobi	S	Kinase binding protein CGI-121	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
WLSH3_k127_4272966_58	515635.Dtur_1425	3.012e-40	156.0	COG2236@1|root,COG2236@2|Bacteria	2|Bacteria	F	xanthine phosphoribosyltransferase activity	gpt	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
WLSH3_k127_4272966_17	1121121.KB894319_gene3797	4.197e-132	434.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,26RUZ@186822|Paenibacillaceae	91061|Bacilli	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU39370	Amidohydro_1,Amidohydro_3
WLSH3_k127_4272966_10	1122947.FR7_3799	1.758e-173	559.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,4H301@909932|Negativicutes	909932|Negativicutes	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
WLSH3_k127_4272966_0	574087.Acear_1941	1.978e-263	820.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,3WB0U@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
WLSH3_k127_4272966_48	1304284.L21TH_1969	9.051e-52	187.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,36DK8@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
WLSH3_k127_4272966_104	1227487.C474_09522	0.0002773	49.0	COG0640@1|root,arCOG00394@2157|Archaea,2XZWN@28890|Euryarchaeota,23Y93@183963|Halobacteria	183963|Halobacteria	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_4272966_77	227086.JGI_V11_45761	7.985e-19	97.0	KOG0266@1|root,KOG0772@1|root,KOG0266@2759|Eukaryota,KOG0772@2759|Eukaryota	2759|Eukaryota	L	enzyme binding	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,WD40
WLSH3_k127_4272966_12	926561.KB900621_gene2825	2.067e-157	509.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,3WAHJ@53433|Halanaerobiales	186801|Clostridia	L	PFAM DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
WLSH3_k127_4272966_69	1343739.PAP_00865	4.023e-29	126.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota,2436Y@183968|Thermococci	183968|Thermococci	P	ABC-type cobalt transport system, permease	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
WLSH3_k127_4272966_33	368408.Tpen_0713	4.017e-72	253.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
WLSH3_k127_4272966_35	485916.Dtox_1967	2.534e-70	247.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,267CI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter related	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
WLSH3_k127_4272966_56	591019.Shell_1603	3.561e-45	177.0	COG0618@1|root,arCOG01565@2157|Archaea,2XQUB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
WLSH3_k127_4272966_102	529709.PYCH_18410	2.221e-05	51.0	arCOG05854@1|root,arCOG05854@2157|Archaea,2Y45W@28890|Euryarchaeota,244I2@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF3194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3194
WLSH3_k127_4272966_88	192952.MM_0674	1.273e-11	70.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,2N9TP@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
WLSH3_k127_4272966_93	339860.Msp_1255	3.029e-09	62.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y1HA@28890|Euryarchaeota,23P8R@183925|Methanobacteria	183925|Methanobacteria	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
WLSH3_k127_4272966_94	415426.Hbut_0574	3.447e-09	65.0	COG2136@1|root,arCOG03247@2157|Archaea,2XR1Z@28889|Crenarchaeota	28889|Crenarchaeota	J	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
WLSH3_k127_4272966_73	342949.PNA2_0520	1.17e-23	106.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
WLSH3_k127_4272966_36	1365176.N186_03870	4.955e-70	248.0	COG2123@1|root,arCOG01574@2157|Archaea,2XQ70@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
WLSH3_k127_4272966_28	523850.TON_0030	1.734e-80	276.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
WLSH3_k127_4272966_49	694429.Pyrfu_1743	1.108e-51	194.0	COG1097@1|root,arCOG00678@2157|Archaea,2XQE2@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1,KH_6
WLSH3_k127_4272966_46	1094980.Mpsy_2727	4.373e-59	213.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
WLSH3_k127_4272966_45	1220534.B655_1254	1.492e-60	219.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23NQD@183925|Methanobacteria	183925|Methanobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
WLSH3_k127_4272966_57	673860.AciM339_0924	6.925e-41	163.0	COG1108@1|root,arCOG01006@2157|Archaea,2XTNB@28890|Euryarchaeota,3F2WR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	ABC 3 transport family	znuB1	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	iAF692.Mbar_A0996	ABC-3
WLSH3_k127_4272966_51	693661.Arcve_1255	5.713e-50	188.0	COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1121 ABC-type Mn Zn transport systems ATPase component	znuC1	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
WLSH3_k127_4272966_84	419665.Maeo_1182	2.254e-13	75.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWKF@28890|Euryarchaeota,23QU2@183939|Methanococci	183939|Methanococci	K	Transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
WLSH3_k127_4272966_80	224325.AF_1983	1.792e-16	91.0	COG0803@1|root,arCOG01005@2157|Archaea,2XVB3@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type metal ion transport system periplasmic component surface adhesin	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
WLSH3_k127_4272966_98	626939.HMPREF9443_00993	5.824e-06	57.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,4H3N3@909932|Negativicutes	909932|Negativicutes	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
WLSH3_k127_4272966_97	1121943.KB899991_gene2553	4.605e-06	53.0	COG3255@1|root,COG3255@2|Bacteria,1N206@1224|Proteobacteria,1S8RI@1236|Gammaproteobacteria,1XKS6@135619|Oceanospirillales	135619|Oceanospirillales	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_4272966_15	1121468.AUBR01000019_gene2622	2.27e-138	460.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_4272966_50	857293.CAAU_2021	2.169e-51	190.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,36DCJ@31979|Clostridiaceae	186801|Clostridia	G	L-ribulose-5-phosphate 4-epimerase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
WLSH3_k127_4272966_37	557599.MKAN_03715	5.072e-69	254.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
WLSH3_k127_4272966_41	693661.Arcve_1526	1.59e-63	232.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,246MG@183980|Archaeoglobi	183980|Archaeoglobi	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
WLSH3_k127_4272966_65	985053.VMUT_1872	3.445e-33	136.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
WLSH3_k127_4272966_96	7719.XP_002129064.1	3.462e-06	50.0	COG5277@1|root,KOG0676@2759|Eukaryota,38C0D@33154|Opisthokonta,3BBGP@33208|Metazoa,3CRBJ@33213|Bilateria,48DQP@7711|Chordata	33208|Metazoa	Z	Actin	ACTG1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0005886,GO:0005912,GO:0005924,GO:0005925,GO:0016020,GO:0030054,GO:0030055,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0070161,GO:0071944,GO:0097433	-	ko:K05692	ko04015,ko04145,ko04210,ko04390,ko04391,ko04510,ko04520,ko04530,ko04611,ko04670,ko04714,ko04745,ko04810,ko04919,ko04921,ko05100,ko05110,ko05130,ko05131,ko05132,ko05164,ko05205,ko05225,ko05410,ko05412,ko05414,ko05416,ko05418,map04015,map04145,map04210,map04390,map04391,map04510,map04520,map04530,map04611,map04670,map04714,map04745,map04810,map04919,map04921,map05100,map05110,map05130,map05131,map05132,map05164,map05205,map05225,map05410,map05412,map05414,map05416,map05418	-	-	-	ko00000,ko00001,ko03019,ko03021,ko03029,ko03036,ko04147,ko04812	-	-	-	Actin
WLSH3_k127_4272966_44	666510.ASAC_0869	5.734e-62	221.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPVP@28889|Crenarchaeota	28889|Crenarchaeota	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_4272966_72	1220534.B655_2435	4.533e-26	122.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_4272966_87	797299.HALLA_13430	1.113e-11	70.0	COG1846@1|root,arCOG00732@2157|Archaea,2XZ9E@28890|Euryarchaeota,23X3E@183963|Halobacteria	183963|Halobacteria	K	COG1846 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
WLSH3_k127_4272966_106	292459.STH620	0.0005687	47.0	COG3255@1|root,COG3255@2|Bacteria,1VFEY@1239|Firmicutes,24QXQ@186801|Clostridia	186801|Clostridia	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_4272966_7	429009.Adeg_1885	2.45e-205	675.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
WLSH3_k127_4272966_34	456320.Mvol_0794	4.513e-72	253.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_4272966_70	706587.Desti_0171	8.296e-28	120.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
WLSH3_k127_4272966_59	1041930.Mtc_2472	4.802e-40	173.0	COG1908@1|root,arCOG02475@2157|Archaea,2XY1E@28890|Euryarchaeota,2NAQW@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	mvhD-2	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
WLSH3_k127_4272966_2	1121472.AQWN01000006_gene1827	2.01e-258	836.0	COG1148@1|root,COG1249@1|root,COG1148@2|Bacteria,COG1249@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,2641A@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
WLSH3_k127_4272966_1	1121430.JMLG01000013_gene1880	1.245e-262	825.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,260TY@186807|Peptococcaceae	186801|Clostridia	C	Aconitase family (aconitate hydratase)	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
WLSH3_k127_4272966_19	1158345.JNLL01000001_gene842	3.506e-125	416.0	COG0045@1|root,COG0045@2|Bacteria,2G3VC@200783|Aquificae	200783|Aquificae	C	ATP citrate lyase citrate-binding	-	-	2.3.3.8	ko:K15231	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
WLSH3_k127_4272966_4	3885.XP_007147365.1	3.322e-227	719.0	COG0045@1|root,KOG1254@2759|Eukaryota,37M9Y@33090|Viridiplantae,3G8F2@35493|Streptophyta,4JMQ5@91835|fabids	35493|Streptophyta	C	ATP-citrate synthase beta chain protein	ACLB-1	GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.3.8	ko:K01648	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,map00020,map00720,map01100,map01110,map01120,map01130	-	R00352	RC00004,RC00067	ko00000,ko00001,ko01000,ko04147	-	-	-	Citrate_synt,CoA_binding,Ligase_CoA
WLSH3_k127_4272966_16	1123508.JH636440_gene2851	1.234e-135	445.0	COG0538@1|root,COG0538@2|Bacteria,2J51C@203682|Planctomycetes	203682|Planctomycetes	C	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
WLSH3_k127_4272966_101	1094980.Mpsy_1362	1.235e-05	57.0	COG2512@1|root,arCOG00377@2157|Archaea,2XY2E@28890|Euryarchaeota	28890|Euryarchaeota	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_4272966_25	386456.JQKN01000001_gene1960	1.036e-94	319.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23NJW@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_4272966_53	339860.Msp_1014	6.954e-48	177.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
WLSH3_k127_4272966_100	1128421.JAGA01000001_gene2345	7.386e-06	57.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CARDB,CBM_3,DUF4091,HYR,Kelch_1,MAM,PA14,PKD,Peptidase_M43,Reprolysin_3
WLSH3_k127_4272966_74	1459636.NTE_01818	1.546e-22	103.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
WLSH3_k127_4272966_81	439235.Dalk_1630	2.16e-16	83.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MM2N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
WLSH3_k127_4272966_18	573063.Metin_0090	1.498e-129	423.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23RI4@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_4272966_38	485913.Krac_5254	2.614e-67	243.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10
WLSH3_k127_4272966_67	5759.rna_EHI_199820-1	8.882e-30	124.0	KOG0078@1|root,KOG0078@2759|Eukaryota,3X8GT@554915|Amoebozoa	554915|Amoebozoa	U	Rab subfamily of small GTPases	-	GO:0000166,GO:0000331,GO:0001882,GO:0001883,GO:0002791,GO:0003674,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006887,GO:0006903,GO:0006904,GO:0006996,GO:0007010,GO:0007033,GO:0007155,GO:0008104,GO:0008150,GO:0009987,GO:0010646,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016339,GO:0017076,GO:0017157,GO:0019001,GO:0022406,GO:0022610,GO:0030029,GO:0030036,GO:0030100,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031156,GO:0031157,GO:0031164,GO:0031410,GO:0031503,GO:0031982,GO:0032101,GO:0032104,GO:0032107,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0033298,GO:0034613,GO:0034629,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043900,GO:0044422,GO:0044424,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045055,GO:0046903,GO:0048278,GO:0048583,GO:0050708,GO:0050789,GO:0050793,GO:0050794,GO:0051046,GO:0051049,GO:0051128,GO:0051179,GO:0051223,GO:0051234,GO:0051600,GO:0051601,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0060176,GO:0060627,GO:0065007,GO:0065008,GO:0070177,GO:0070201,GO:0070727,GO:0071840,GO:0080134,GO:0080135,GO:0090087,GO:0090522,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098609,GO:0098742,GO:0098805,GO:0099022,GO:0099503,GO:0140025,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1903530	-	ko:K07901	ko04144,ko04152,ko04530,ko04972,map04144,map04152,map04530,map04972	-	-	-	ko00000,ko00001,ko03036,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_4272966_26	290397.Adeh_1958	3.101e-85	291.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,2YZ1X@29|Myxococcales	1224|Proteobacteria	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_4272966_54	647113.Metok_0149	3.939e-46	173.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
WLSH3_k127_4272966_40	1487921.DP68_17915	7.606e-66	233.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,36F30@31979|Clostridiaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
WLSH3_k127_4272966_24	224325.AF_1958	3.048e-99	338.0	COG1775@1|root,arCOG04464@2157|Archaea,2XZP9@28890|Euryarchaeota,246DT@183980|Archaeoglobi	183980|Archaeoglobi	E	2-hydroxyglutaryl-CoA dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
WLSH3_k127_4272966_85	1232410.KI421421_gene3270	5.993e-13	81.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
WLSH3_k127_4272966_6	644282.Deba_0138	6.588e-214	679.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_4272966_8	644282.Deba_0138	9.5e-199	634.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WLSH3_k127_4272966_47	523850.TON_0372	2.2e-52	190.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2439Z@183968|Thermococci	183968|Thermococci	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WLSH3_k127_4272966_3	555088.DealDRAFT_2538	3.943e-250	784.0	COG1960@1|root,COG1960@2|Bacteria,1V03D@1239|Firmicutes,24A8N@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
WLSH3_k127_4272966_105	1120977.JHUX01000008_gene537	0.0003551	50.0	29W5V@1|root,30HQZ@2|Bacteria,1RFZX@1224|Proteobacteria,1S4QF@1236|Gammaproteobacteria,3NNM4@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184,YdjM
WLSH3_k127_4272966_90	685727.REQ_38550	3.072e-10	71.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,4FVJZ@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_4272966_11	1191523.MROS_1378	8.253e-165	527.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
WLSH3_k127_4272966_32	945713.IALB_0205	6.122e-75	255.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
WLSH3_k127_4272966_29	1183377.Py04_1132	1.151e-77	272.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota,242VZ@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
WLSH3_k127_4272966_30	1384484.AEQU_0877	1.374e-77	269.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4CV8F@84998|Coriobacteriia	84998|Coriobacteriia	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
WLSH3_k127_4272966_52	156889.Mmc1_0883	4.056e-49	184.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
WLSH3_k127_4272966_23	70601.3257714	3.753e-104	355.0	COG0374@1|root,arCOG01549@2157|Archaea,2Y2IM@28890|Euryarchaeota,2434B@183968|Thermococci	183968|Thermococci	C	Nickel-dependent hydrogenase	-	-	1.12.1.3,1.12.1.5	ko:K17993	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
WLSH3_k127_4272966_22	1121324.CLIT_10c04520	2.264e-108	370.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,25SG3@186804|Peptostreptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_4272966_64	398512.JQKC01000015_gene4671	6.671e-34	142.0	COG1409@1|root,COG1409@2|Bacteria,1UA0Q@1239|Firmicutes,24VZZ@186801|Clostridia	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
WLSH3_k127_4272966_21	644966.Tmar_0462	4.351e-112	387.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3WDH0@538999|Clostridiales incertae sedis	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
WLSH3_k127_4272966_99	391589.RGAI101_429	7.043e-06	55.0	2B107@1|root,31TDE@2|Bacteria,1RITJ@1224|Proteobacteria,2U99C@28211|Alphaproteobacteria,2P3J1@2433|Roseobacter	28211|Alphaproteobacteria	S	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	RNase_Zc3h12a
WLSH3_k127_4272966_5	573413.Spirs_3146	9.064e-223	706.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WLSH3_k127_4272966_83	399550.Smar_0165	1.031e-14	82.0	COG1392@1|root,arCOG02640@2157|Archaea,2XQYH@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Putitive phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
WLSH3_k127_4272966_68	1219084.AP014508_gene1582	2.463e-29	131.0	COG0306@1|root,COG0306@2|Bacteria,2GCJD@200918|Thermotogae	200918|Thermotogae	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
WLSH3_k127_4272966_66	1191523.MROS_2656	6.341e-31	131.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
WLSH3_k127_4272966_60	1303518.CCALI_00908	1.531e-37	147.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	tdsD	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_4272966_14	1121472.AQWN01000003_gene1546	1.653e-142	463.0	COG1960@1|root,COG1960@2|Bacteria,1TRR9@1239|Firmicutes,24AJB@186801|Clostridia,260H9@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_4272966_91	1006006.Mcup_0797	9.142e-10	63.0	COG1146@1|root,arCOG04548@2157|Archaea	2157|Archaea	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
WLSH3_k127_4272966_27	1128421.JAGA01000002_gene776	1.663e-84	289.0	COG3342@1|root,COG3342@2|Bacteria,2NP87@2323|unclassified Bacteria	2|Bacteria	S	Family of unknown function (DUF1028)	fimA	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
WLSH3_k127_4272966_43	202698.XP_007386910.1	6.128e-63	228.0	COG1028@1|root,KOG1200@2759|Eukaryota,39ZTQ@33154|Opisthokonta,3NYYN@4751|Fungi,3V3QM@5204|Basidiomycota,225V2@155619|Agaricomycetes,3H97V@355688|Agaricomycetes incertae sedis	4751|Fungi	Q	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
WLSH3_k127_4272966_71	1033810.HLPCO_000543	7.186e-27	122.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
WLSH3_k127_4272966_42	768706.Desor_1472	3.059e-63	226.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_4316134_1	1035195.HMPREF9997_01868	1.306e-08	63.0	2BTC8@1|root,32NI0@2|Bacteria,2IPGR@201174|Actinobacteria,22PG7@1653|Corynebacteriaceae	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4316134_0	536227.CcarbDRAFT_3720	9.909e-09	60.0	2D1AQ@1|root,32TA9@2|Bacteria,1VADA@1239|Firmicutes,24MZG@186801|Clostridia,36MDP@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4331695_0	926569.ANT_01250	2.448e-15	85.0	COG0078@1|root,COG0078@2|Bacteria,2G7QE@200795|Chloroflexi	200795|Chloroflexi	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	-	2.1.3.9	ko:K09065	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
WLSH3_k127_438718_1	1459636.NTE_00038	6.659e-55	195.0	COG0346@1|root,arCOG02708@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
WLSH3_k127_438718_3	1280390.CBQR020000149_gene3863	3.572e-47	186.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli,26RUX@186822|Paenibacillaceae	91061|Bacilli	P	Arsenical pump membrane protein	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	CitMHS
WLSH3_k127_438718_2	1123371.ATXH01000003_gene1893	3.843e-51	188.0	COG1926@1|root,COG1926@2|Bacteria	2|Bacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
WLSH3_k127_438718_5	1356854.N007_12980	2.443e-22	98.0	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli,27AGD@186823|Alicyclobacillaceae	91061|Bacilli	S	Uncharacterized conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
WLSH3_k127_438718_4	768710.DesyoDRAFT_2688	6.295e-30	130.0	COG0500@1|root,COG2226@2|Bacteria,1VC2E@1239|Firmicutes,25BWN@186801|Clostridia,263TU@186807|Peptococcaceae	186801|Clostridia	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
WLSH3_k127_438718_0	1120965.AUBV01000009_gene2980	4.53e-56	201.0	COG1018@1|root,COG1018@2|Bacteria,4NM4J@976|Bacteroidetes	976|Bacteroidetes	C	flavodoxin reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,FAD_binding_8,NAD_binding_1
WLSH3_k127_454838_1	1459636.NTE_02945	2.247e-36	150.0	COG0611@1|root,arCOG00638@2157|Archaea,41SIN@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WLSH3_k127_454838_0	694429.Pyrfu_0839	1.314e-57	208.0	COG1031@1|root,arCOG01359@2157|Archaea,2XPM2@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_4550379_0	868131.MSWAN_0527	1.425e-31	134.0	COG0164@1|root,arCOG04121@2157|Archaea,2XZEX@28890|Euryarchaeota,23PK4@183925|Methanobacteria	183925|Methanobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
WLSH3_k127_4550379_3	694431.DESACE_06605	3.734e-08	60.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
WLSH3_k127_4550379_2	1132855.KB913035_gene1507	2.887e-12	76.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
WLSH3_k127_4550379_1	335543.Sfum_1818	4.952e-21	94.0	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MS5T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
WLSH3_k127_458332_13	195522.BD01_1055	1.116e-73	256.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,242R3@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
WLSH3_k127_458332_7	1343739.PAP_05870	1.061e-120	404.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
WLSH3_k127_458332_16	264732.Moth_0446	5.87e-69	246.0	COG1856@1|root,COG1856@2|Bacteria,1V23U@1239|Firmicutes,24E3M@186801|Clostridia,42GSP@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
WLSH3_k127_458332_34	339860.Msp_0396	6.25e-07	58.0	arCOG06453@1|root,arCOG06453@2157|Archaea,2XZAX@28890|Euryarchaeota,23P5V@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_458332_28	246969.TAM4_2003	2.544e-11	70.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
WLSH3_k127_458332_12	339860.Msp_0395	3.23e-85	291.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
WLSH3_k127_458332_20	573063.Metin_1389	6.076e-46	171.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
WLSH3_k127_458332_19	523845.AQXV01000025_gene1493	4.964e-46	176.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23QQD@183939|Methanococci	183939|Methanococci	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
WLSH3_k127_458332_11	186497.PF1763	1.378e-88	306.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,242M3@183968|Thermococci	183968|Thermococci	S	gtp1 obg	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
WLSH3_k127_458332_29	456320.Mvol_0946	7.843e-10	67.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,23QED@183939|Methanococci	183939|Methanococci	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
WLSH3_k127_458332_5	342949.PNA2_0288	5.42e-150	486.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
WLSH3_k127_458332_18	694429.Pyrfu_1517	5.285e-47	174.0	COG1781@1|root,arCOG04229@2157|Archaea,2XQJR@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
WLSH3_k127_458332_27	69014.TK1601	3.361e-14	77.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y1TB@28890|Euryarchaeota,244C3@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
WLSH3_k127_458332_1	529709.PYCH_15740	1.066e-230	728.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3
WLSH3_k127_458332_17	1459636.NTE_01560	1.235e-49	182.0	COG1573@1|root,arCOG00905@2157|Archaea,41SJ1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
WLSH3_k127_458332_2	70601.3258418	9.785e-199	629.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
WLSH3_k127_458332_25	593117.TGAM_1178	2.261e-18	89.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
WLSH3_k127_458332_10	868131.MSWAN_1530	2.325e-92	322.0	COG1032@1|root,arCOG01355@2157|Archaea,2XUPV@28890|Euryarchaeota,23NTW@183925|Methanobacteria	183925|Methanobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_458332_8	224719.Abm4_0226	6.541e-120	400.0	COG1208@1|root,arCOG00668@2157|Archaea,2Y87C@28890|Euryarchaeota,23PZH@183925|Methanobacteria	183925|Methanobacteria	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
WLSH3_k127_458332_30	456442.Mboo_1535	9.088e-09	59.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
WLSH3_k127_458332_4	186497.PF2015	1.502e-168	557.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
WLSH3_k127_458332_14	1408422.JHYF01000017_gene1860	3.3e-72	254.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,36DTB@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
WLSH3_k127_458332_3	443254.Marpi_1140	3.33e-181	584.0	COG2414@1|root,COG2414@2|Bacteria,2GCI5@200918|Thermotogae	200918|Thermotogae	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_458332_6	192952.MM_0883	9.831e-143	475.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
WLSH3_k127_458332_23	338966.Ppro_2866	5.365e-22	108.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_458332_15	360910.BAV0089	5.333e-70	256.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	2.3.1.157,2.3.1.79,2.7.7.23	ko:K00661,ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
WLSH3_k127_458332_22	693661.Arcve_0927	3.832e-26	113.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,2467U@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
WLSH3_k127_458332_33	1459636.NTE_01660	2.59e-07	55.0	arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_458332_0	1365176.N186_02525	4.725e-280	878.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
WLSH3_k127_458332_24	399550.Smar_0716	8.584e-20	91.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
WLSH3_k127_458332_26	368408.Tpen_0662	1.725e-15	78.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
WLSH3_k127_458332_9	439481.Aboo_0490	1.984e-103	346.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
WLSH3_k127_458332_32	444158.MmarC6_0832	7.595e-08	62.0	COG3390@1|root,arCOG02258@2157|Archaea,2XYKW@28890|Euryarchaeota,23R24@183939|Methanococci	183939|Methanococci	S	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	tRNA_anti-codon
WLSH3_k127_458332_21	386456.JQKN01000002_gene2878	1.355e-34	136.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,23P0P@183925|Methanobacteria	183925|Methanobacteria	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
WLSH3_k127_458332_35	374847.Kcr_1531	6.807e-06	57.0	COG1467@1|root,arCOG04110@2157|Archaea	2157|Archaea	F	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
WLSH3_k127_458332_36	1120983.KB894578_gene3705	0.0003987	44.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,2TST9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG0524 Sugar kinases, ribokinase family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
WLSH3_k127_458332_31	469616.FMAG_01867	9.953e-09	65.0	COG1502@1|root,COG1502@2|Bacteria,3789J@32066|Fusobacteria	32066|Fusobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
WLSH3_k127_4595861_2	1122179.KB890463_gene2122	3.771e-06	58.0	COG0842@1|root,COG0842@2|Bacteria,4NDU0@976|Bacteroidetes,1J0A1@117747|Sphingobacteriia	976|Bacteroidetes	V	ABC-2 family transporter protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_4595861_1	648996.Theam_0865	2.388e-09	69.0	COG0842@1|root,COG0842@2|Bacteria,2G3Z4@200783|Aquificae	200783|Aquificae	V	ABC-2 family transporter protein	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3
WLSH3_k127_4595861_0	64471.sync_2130	1.799e-24	108.0	COG1131@1|root,COG1131@2|Bacteria,1G1IU@1117|Cyanobacteria,1GZ9M@1129|Synechococcus	1117|Cyanobacteria	V	ABC-type multidrug transport system, ATPase component	ccmA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_4645812_51	1121875.KB907560_gene526	1.694e-09	61.0	2DNPH@1|root,32YF1@2|Bacteria,4NVUP@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4645812_12	635013.TherJR_2567	3.652e-84	285.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,26123@186807|Peptococcaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
WLSH3_k127_4645812_27	497965.Cyan7822_2631	1.079e-30	132.0	COG0419@1|root,COG2319@1|root,COG0419@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,3KH8A@43988|Cyanothece	1117|Cyanobacteria	L	WD-40 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	WD40
WLSH3_k127_4645812_13	926569.ANT_16930	1.422e-66	240.0	COG2234@1|root,COG2234@2|Bacteria,2G6WJ@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
WLSH3_k127_4645812_22	697281.Mahau_1403	1.65e-42	171.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia,42GGS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
WLSH3_k127_4645812_9	1121342.AUCO01000004_gene608	3.569e-97	325.0	COG0863@1|root,COG0863@2|Bacteria,1TR56@1239|Firmicutes,248NR@186801|Clostridia	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
WLSH3_k127_4645812_11	1131266.ARWQ01000001_gene1315	2.177e-87	301.0	COG0863@1|root,arCOG00890@2157|Archaea	2157|Archaea	L	PFAM DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00590,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase,UPF0020
WLSH3_k127_4645812_25	1365176.N186_09045	1.437e-34	142.0	COG2820@1|root,arCOG01324@2157|Archaea,2XPX2@28889|Crenarchaeota	1365176.N186_09045|-	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	-
WLSH3_k127_4645812_23	632335.Calkr_2642	1.256e-40	158.0	COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,25E4K@186801|Clostridia,42IGI@68295|Thermoanaerobacterales	186801|Clostridia	L	FES	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4,SfsA
WLSH3_k127_4645812_19	573063.Metin_1141	1.959e-48	180.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,23QUS@183939|Methanococci	183939|Methanococci	C	TIGRFAM archaeoflavoprotein AfpA	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
WLSH3_k127_4645812_33	471853.Bcav_1677	7e-26	121.0	COG2141@1|root,COG2141@2|Bacteria,2IEM9@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
WLSH3_k127_4645812_45	1041930.Mtc_0135	3.252e-14	83.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
WLSH3_k127_4645812_56	315749.Bcer98_1455	5.688e-05	55.0	COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,4H9Q9@91061|Bacilli,1ZBN7@1386|Bacillus	91061|Bacilli	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
WLSH3_k127_4645812_15	1173024.KI912151_gene2275	4.049e-59	212.0	COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,1JI7U@1189|Stigonemataceae	1117|Cyanobacteria	L	FES	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
WLSH3_k127_4645812_4	694440.JOMF01000004_gene1372	1.985e-140	458.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,2NADB@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
WLSH3_k127_4645812_8	647113.Metok_1611	6.133e-107	360.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,23QPC@183939|Methanococci	183939|Methanococci	O	PFAM SufBD protein	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
WLSH3_k127_4645812_17	580331.Thit_2296	1.326e-52	195.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,2489I@186801|Clostridia,42FAW@68295|Thermoanaerobacterales	186801|Clostridia	O	TIGRFAM ATPase SufC, SUF system FeS cluster assembly	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
WLSH3_k127_4645812_46	1150474.JQJI01000029_gene908	4.554e-14	78.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WLSH3_k127_4645812_3	1499967.BAYZ01000180_gene4413	3.649e-170	544.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4645812_32	1343739.PAP_04395	5.149e-26	114.0	COG4720@1|root,arCOG05752@2157|Archaea,2XYJ2@28890|Euryarchaeota,243PD@183968|Thermococci	183968|Thermococci	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
WLSH3_k127_4645812_18	387631.Asulf_01218	1.455e-48	176.0	COG2033@1|root,arCOG02146@2157|Archaea,2Y3EA@28890|Euryarchaeota	28890|Euryarchaeota	C	Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide	sorA	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
WLSH3_k127_4645812_28	521045.Kole_1186	4.622e-30	126.0	COG1670@1|root,COG1670@2|Bacteria,2GCZ2@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
WLSH3_k127_4645812_0	926569.ANT_18080	1.981e-304	947.0	COG0021@1|root,COG0021@2|Bacteria,2G63Z@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
WLSH3_k127_4645812_31	906968.Trebr_1157	2.206e-26	113.0	COG3871@1|root,COG3871@2|Bacteria,2J9F1@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
WLSH3_k127_4645812_30	1341157.RF007C_05140	2.691e-28	119.0	COG1846@1|root,COG1846@2|Bacteria,1V8KT@1239|Firmicutes,24B99@186801|Clostridia,3WGSA@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulators	mgrA	-	-	-	-	-	-	-	-	-	-	-	MarR
WLSH3_k127_4645812_7	368407.Memar_2034	2.663e-108	369.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4645812_36	1125863.JAFN01000001_gene1708	5.694e-23	104.0	COG1917@1|root,COG1917@2|Bacteria,1MZD8@1224|Proteobacteria,42W0P@68525|delta/epsilon subdivisions,2WRDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_4645812_14	891968.Anamo_1805	3.771e-62	230.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_4645812_2	309803.CTN_1411	8.109e-192	614.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GC9M@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	POR,POR_N
WLSH3_k127_4645812_5	868131.MSWAN_0191	3.543e-118	388.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,23PWY@183925|Methanobacteria	183925|Methanobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
WLSH3_k127_4645812_40	565033.GACE_1571	1.41e-18	93.0	COG1853@1|root,arCOG02017@2157|Archaea,2XXYS@28890|Euryarchaeota,247HG@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
WLSH3_k127_4645812_1	1304284.L21TH_0179	1.681e-225	710.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36HQZ@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh,Pro_dh
WLSH3_k127_4645812_20	368407.Memar_2381	1.049e-44	173.0	arCOG03714@1|root,arCOG07526@1|root,arCOG03714@2157|Archaea,arCOG07526@2157|Archaea,2XXQF@28890|Euryarchaeota	28890|Euryarchaeota	FV	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Mrr_cat
WLSH3_k127_4645812_44	391623.TERMP_00370	1.229e-14	75.0	arCOG07495@1|root,arCOG07495@2157|Archaea,2Y1A6@28890|Euryarchaeota,244Q6@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
WLSH3_k127_4645812_50	1122927.KB895412_gene1249	1.111e-11	78.0	COG3458@1|root,COG3458@2|Bacteria,1V2Z0@1239|Firmicutes,4IRU6@91061|Bacilli,276XB@186822|Paenibacillaceae	91061|Bacilli	Q	Acetyl esterase	cah3	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
WLSH3_k127_4645812_24	1114856.C496_20025	6.404e-40	161.0	COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,23RY4@183963|Halobacteria	183963|Halobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_4645812_21	698761.RTCIAT899_CH04575	6.182e-43	162.0	COG0346@1|root,COG0346@2|Bacteria,1PW4X@1224|Proteobacteria,2V7BJ@28211|Alphaproteobacteria,4BHUY@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4645812_48	1094715.CM001375_gene131	3.295e-12	78.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1JD08@118969|Legionellales	1236|Gammaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
WLSH3_k127_4645812_10	1042163.BRLA_c025150	1.148e-88	296.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,4HB82@91061|Bacilli,26UCG@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
WLSH3_k127_4645812_26	521045.Kole_0192	2.841e-31	137.0	COG5276@1|root,COG5276@2|Bacteria,2GDIA@200918|Thermotogae	200918|Thermotogae	S	PFAM LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
WLSH3_k127_4645812_43	452637.Oter_0018	2.667e-15	82.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
WLSH3_k127_4645812_16	1120950.KB892755_gene5928	1.024e-55	204.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_4645812_47	999630.TUZN_0507	9.361e-13	74.0	COG1848@1|root,arCOG02221@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
WLSH3_k127_4645812_57	933801.Ahos_1978	9.549e-05	48.0	arCOG07723@1|root,arCOG07723@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4645812_29	693661.Arcve_1788	6.646e-29	120.0	COG1487@1|root,arCOG02219@2157|Archaea,2Y1PM@28890|Euryarchaeota	28890|Euryarchaeota	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
WLSH3_k127_4645812_53	1227497.C491_17147	5.756e-06	52.0	COG1753@1|root,arCOG02681@2157|Archaea,2Y0E4@28890|Euryarchaeota,23XF7@183963|Halobacteria	183963|Halobacteria	K	Pfam:DUF217	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
WLSH3_k127_4645812_39	572546.Arcpr_1217	1.343e-19	90.0	COG2002@1|root,arCOG00820@2157|Archaea	2157|Archaea	K	Transcriptional regulator, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
WLSH3_k127_4645812_35	572546.Arcpr_1216	3.174e-23	106.0	arCOG06028@1|root,arCOG06028@2157|Archaea,2Y3Q1@28890|Euryarchaeota,2472W@183980|Archaeoglobi	183980|Archaeoglobi	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
WLSH3_k127_4645812_54	1249975.JQLP01000003_gene76	2.008e-05	57.0	COG1361@1|root,COG3266@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1HZAG@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
WLSH3_k127_4645812_42	344747.PM8797T_07347	7.019e-17	93.0	COG4447@1|root,COG4447@2|Bacteria,2IXMV@203682|Planctomycetes	203682|Planctomycetes	S	to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
WLSH3_k127_4645812_38	565033.GACE_1252	2.249e-21	95.0	arCOG03086@1|root,arCOG03086@2157|Archaea,2Y6GQ@28890|Euryarchaeota,247DW@183980|Archaeoglobi	183980|Archaeoglobi	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
WLSH3_k127_4645812_34	323259.Mhun_1747	1.408e-23	101.0	COG1598@1|root,arCOG02412@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4645812_37	572478.Vdis_1328	1.285e-21	99.0	arCOG07589@1|root,arCOG07589@2157|Archaea,2XS0I@28889|Crenarchaeota	28889|Crenarchaeota	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
WLSH3_k127_4645812_41	243090.RB4278	3.377e-17	94.0	COG1633@1|root,COG4447@1|root,COG1633@2|Bacteria,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	AurF,Ferritin-like,Sortilin-Vps10
WLSH3_k127_4645812_6	1170562.Cal6303_2050	8.284e-114	372.0	COG2227@1|root,COG2227@2|Bacteria,1GPYP@1117|Cyanobacteria	1117|Cyanobacteria	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_4645812_52	572546.Arcpr_1176	1.125e-07	60.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y0GG@28890|Euryarchaeota	28890|Euryarchaeota	V	Nucleic acid-binding protein contains PIN	-	-	-	ko:K07066	-	-	-	-	ko00000	-	-	-	DUF3368
WLSH3_k127_4645812_58	572546.Arcpr_1178	0.0007114	47.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2XZI9@28890|Euryarchaeota	28890|Euryarchaeota	K	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
WLSH3_k127_4690545_2	457570.Nther_0880	5.881e-38	148.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5
WLSH3_k127_4690545_0	1280692.AUJL01000011_gene3155	3.672e-142	467.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,36FKP@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0371 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
WLSH3_k127_4690545_4	1220534.B655_1160	6.198e-33	134.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
WLSH3_k127_4690545_3	517417.Cpar_1856	3.762e-37	152.0	COG1237@1|root,COG1237@2|Bacteria,1FETS@1090|Chlorobi	1090|Chlorobi	S	PFAM beta-lactamase domain protein	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
WLSH3_k127_4690545_5	368407.Memar_1533	4.113e-25	121.0	arCOG03847@1|root,arCOG03847@2157|Archaea,2XYIE@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4690545_1	868131.MSWAN_1950	1.149e-99	344.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
WLSH3_k127_478679_0	926569.ANT_27060	1.725e-62	227.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_478679_3	1304888.ATWF01000001_gene912	1.136e-15	87.0	COG1763@1|root,COG1763@2|Bacteria,2GFTP@200930|Deferribacteres	200930|Deferribacteres	H	Molybdopterin guanine dinucleotide synthesis protein B	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
WLSH3_k127_478679_1	1455608.JDTH01000002_gene554	7.25e-58	211.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,23S1T@183963|Halobacteria	183963|Halobacteria	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	ogg	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
WLSH3_k127_478679_2	368408.Tpen_0623	2.539e-36	152.0	COG2219@1|root,arCOG03013@2157|Archaea,2XQ8M@28889|Crenarchaeota	28889|Crenarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
WLSH3_k127_478679_4	292459.STH3037	1.825e-08	62.0	COG0500@1|root,COG0500@2|Bacteria,1UIRP@1239|Firmicutes,25EQI@186801|Clostridia	186801|Clostridia	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_4991030_6	1194526.A284_01020	1.503e-08	62.0	COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,4HG02@91061|Bacilli,4GXMP@90964|Staphylococcaceae	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WLSH3_k127_4991030_3	1283300.ATXB01000002_gene2631	2.844e-25	113.0	COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_4991030_0	394221.Mmar10_1145	3.751e-57	205.0	29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,2UAW7@28211|Alphaproteobacteria,43XXB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
WLSH3_k127_4991030_1	404380.Gbem_3219	1.461e-34	147.0	COG2234@1|root,COG2234@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions,2X60E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
WLSH3_k127_4991030_7	565033.GACE_1023	4.015e-08	64.0	COG0582@1|root,arCOG01242@2157|Archaea,2Y83U@28890|Euryarchaeota,246MT@183980|Archaeoglobi	2157|Archaea	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase,zinc_ribbon_2
WLSH3_k127_4991030_5	189426.PODO_02565	5.683e-13	81.0	COG4447@1|root,COG4447@2|Bacteria,1VEMZ@1239|Firmicutes,4HPDA@91061|Bacilli,26YWY@186822|Paenibacillaceae	91061|Bacilli	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
WLSH3_k127_4991030_8	673860.AciM339_0373	3.206e-07	63.0	arCOG07561@1|root,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota	28890|Euryarchaeota	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553,HTH_IclR
WLSH3_k127_4991030_9	373903.Hore_11350	3.579e-05	57.0	COG1075@1|root,COG1075@2|Bacteria,1URR6@1239|Firmicutes,259N3@186801|Clostridia,3WB3G@53433|Halanaerobiales	186801|Clostridia	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
WLSH3_k127_4991030_4	1089553.Tph_c09570	1.623e-19	98.0	COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,24DU6@186801|Clostridia,42G65@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM alpha beta hydrolase	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
WLSH3_k127_4991030_2	1195236.CTER_2520	5.784e-26	113.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WLSH3_k127_4997621_16	245174.XP_009267943.1	7.517e-11	72.0	COG0468@1|root,KOG1434@2759|Eukaryota,39J83@33154|Opisthokonta,3NVB0@4751|Fungi,3UY0V@5204|Basidiomycota	4751|Fungi	L	Belongs to the RecA family	-	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000709,GO:0000724,GO:0000725,GO:0000730,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006311,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007130,GO:0007131,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010520,GO:0010564,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022414,GO:0022607,GO:0030554,GO:0031323,GO:0031974,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0033043,GO:0033554,GO:0034622,GO:0034641,GO:0035639,GO:0035822,GO:0035825,GO:0036094,GO:0040020,GO:0042148,GO:0042623,GO:0042802,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044877,GO:0045003,GO:0045132,GO:0045143,GO:0046483,GO:0048285,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051128,GO:0051171,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051445,GO:0051716,GO:0051726,GO:0051783,GO:0060255,GO:0060631,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070192,GO:0070193,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090735,GO:0097159,GO:0097367,GO:0098813,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1903046,GO:1905334,GO:2000241	-	ko:K10872,ko:K14545	ko03008,ko04113,map03008,map04113	-	-	-	ko00000,ko00001,ko03009,ko03400	-	-	-	HHH_5,Rad51
WLSH3_k127_4997621_9	1089553.Tph_c19600	1.366e-37	145.0	COG0509@1|root,COG0509@2|Bacteria,1V9VC@1239|Firmicutes,24QN1@186801|Clostridia,42IJ8@68295|Thermoanaerobacterales	186801|Clostridia	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
WLSH3_k127_4997621_19	572546.Arcpr_1164	5.741e-06	58.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,245XC@183980|Archaeoglobi	28890|Euryarchaeota	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22
WLSH3_k127_4997621_15	439235.Dalk_2984	2.417e-14	85.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2MI3F@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD1	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_4997621_6	1089553.Tph_c19580	4.966e-51	195.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
WLSH3_k127_4997621_1	909663.KI867150_gene284	7.915e-164	531.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MQ89@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
WLSH3_k127_4997621_4	477974.Daud_0678	1.742e-69	245.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia,266KR@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_4997621_8	525904.Tter_1676	2.658e-43	163.0	COG1225@1|root,COG1225@2|Bacteria,2NPEE@2323|unclassified Bacteria	2|Bacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WLSH3_k127_4997621_7	1123278.KB893499_gene371	1.003e-47	176.0	COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,47PUA@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WLSH3_k127_4997621_14	1123376.AUIU01000011_gene1067	3.792e-15	87.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
WLSH3_k127_4997621_18	1499967.BAYZ01000011_gene5208	4.762e-10	72.0	COG2378@1|root,COG2378@2|Bacteria	2|Bacteria	K	regulation of single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	WYL
WLSH3_k127_4997621_5	593117.TGAM_2062	3.109e-53	201.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2433R@183968|Thermococci	183968|Thermococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rep_fac_C,RuvB_N
WLSH3_k127_4997621_0	264732.Moth_1918	7.45e-218	690.0	COG1061@1|root,COG1061@2|Bacteria,1TPDM@1239|Firmicutes,24CK8@186801|Clostridia	186801|Clostridia	KL	Helicase conserved C-terminal domain	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
WLSH3_k127_4997621_10	871968.DESME_08385	9.076e-27	125.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,24AKU@186801|Clostridia,266YC@186807|Peptococcaceae	186801|Clostridia	EGP	MFS_1 like family	-	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_4997621_12	1236689.MMALV_15340	2.339e-23	109.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,3F2PH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	RIO1 family	rio1	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
WLSH3_k127_4997621_11	1236689.MMALV_15340	1.287e-25	117.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,3F2PH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	RIO1 family	rio1	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
WLSH3_k127_4997621_3	406124.ACPC01000047_gene1729	9.755e-75	265.0	COG3616@1|root,COG3616@2|Bacteria,1TSES@1239|Firmicutes,4HA93@91061|Bacilli,1ZQJR@1386|Bacillus	91061|Bacilli	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
WLSH3_k127_4997621_17	997346.HMPREF9374_2118	3.012e-10	68.0	COG2318@1|root,COG2318@2|Bacteria,1V6FD@1239|Firmicutes,4HJI8@91061|Bacilli,27C7I@186824|Thermoactinomycetaceae	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
WLSH3_k127_4997621_2	203119.Cthe_0231	7.722e-102	344.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3WK9K@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
WLSH3_k127_5166348_3	1229909.NSED_00270	2.119e-16	82.0	COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
WLSH3_k127_5166348_1	999630.TUZN_2126	1.08e-47	177.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
WLSH3_k127_5166348_0	710696.Intca_3130	9.927e-95	322.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FJQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
WLSH3_k127_5166348_2	1365176.N186_02585	4.765e-43	166.0	COG0624@1|root,arCOG01107@2157|Archaea,2XPWH@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	argE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
WLSH3_k127_529478_2	768670.Calni_0815	3.481e-10	71.0	28K4S@1|root,2Z9TM@2|Bacteria,2GGFH@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_529478_3	243164.DET1333	0.0009052	47.0	COG1030@1|root,COG1030@2|Bacteria,2GAU7@200795|Chloroflexi,34DCY@301297|Dehalococcoidia	301297|Dehalococcoidia	O	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
WLSH3_k127_529478_0	673860.AciM339_0586	1.483e-53	203.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y726@28890|Euryarchaeota,3F38D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K19576	-	-	-	-	ko00000,ko02000	2.A.1.2.10	-	-	MFS_1
WLSH3_k127_529478_1	269797.Mbar_A3343	2.121e-20	101.0	COG0454@1|root,arCOG05161@2157|Archaea,2XXI2@28890|Euryarchaeota,2N9P8@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_5344574_18	273075.Ta0890	1.049e-10	66.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,24255@183967|Thermoplasmata	183967|Thermoplasmata	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
WLSH3_k127_5344574_1	453591.Igni_1108	7.915e-89	310.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
WLSH3_k127_5344574_12	186497.PF0844	4.156e-18	96.0	arCOG02979@1|root,arCOG02979@2157|Archaea,2XT08@28890|Euryarchaeota,242QH@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5344574_2	891968.Anamo_1109	7.582e-80	277.0	COG2516@1|root,COG2516@2|Bacteria,3TB3Y@508458|Synergistetes	508458|Synergistetes	S	Radical SAM domain protein	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
WLSH3_k127_5344574_3	744872.Spica_1727	3.493e-77	265.0	COG0095@1|root,COG0095@2|Bacteria,2J7CV@203691|Spirochaetes	203691|Spirochaetes	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
WLSH3_k127_5344574_22	525268.HMPREF0308_0017	1.761e-06	53.0	COG0095@1|root,COG0095@2|Bacteria,2GJV5@201174|Actinobacteria,22JQ7@1653|Corynebacteriaceae	201174|Actinobacteria	H	lipoate-protein ligase A	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
WLSH3_k127_5344574_16	1463909.KL585962_gene4754	1.946e-12	74.0	2BA9I@1|root,323PQ@2|Bacteria,2H8E5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5344574_5	1191523.MROS_0720	5.724e-58	213.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	CP_1064	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_5344574_20	29540.C481_00355	6.188e-09	65.0	COG3413@1|root,arCOG02271@2157|Archaea,2XWZT@28890|Euryarchaeota,23VGR@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
WLSH3_k127_5344574_23	999411.HMPREF1092_03149	0.0003731	52.0	arCOG05209@1|root,31PIN@2|Bacteria,1V5G2@1239|Firmicutes,248EN@186801|Clostridia,36FIW@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
WLSH3_k127_5344574_19	1121405.dsmv_1244	3.554e-09	67.0	COG1082@1|root,COG1082@2|Bacteria,1N8KJ@1224|Proteobacteria,42R37@68525|delta/epsilon subdivisions,2WMX6@28221|Deltaproteobacteria,2MJQB@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_5344574_8	5722.XP_001584373.1	8.456e-39	151.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_5344574_10	4081.Solyc11g012460.1.1	6.644e-28	119.0	COG1100@1|root,KOG0087@2759|Eukaryota,37N1I@33090|Viridiplantae,3GF78@35493|Streptophyta,44BGP@71274|asterids	35493|Streptophyta	U	Rab subfamily of small GTPases	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005886,GO:0016020,GO:0031090,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0071944,GO:0098588,GO:0098805	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_5344574_13	1122927.KB895414_gene5151	3.74e-15	84.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,4HEU9@91061|Bacilli,26SM9@186822|Paenibacillaceae	91061|Bacilli	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
WLSH3_k127_5344574_11	1123511.KB905841_gene1366	3.386e-23	108.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,4H2SY@909932|Negativicutes	909932|Negativicutes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
WLSH3_k127_5344574_0	1293597.BN147_06695	2.645e-94	315.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,4HAB1@91061|Bacilli,3F3SY@33958|Lactobacillaceae	91061|Bacilli	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	iSB619.SA_RS06920	ABC_tran
WLSH3_k127_5344574_7	696281.Desru_1676	1.385e-54	203.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,2611K@186807|Peptococcaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
WLSH3_k127_5344574_6	593750.Metfor_0424	6.707e-55	205.0	COG0573@1|root,arCOG00167@2157|Archaea,2XVD5@28890|Euryarchaeota	28890|Euryarchaeota	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
WLSH3_k127_5344574_14	583355.Caka_2255	1.174e-14	85.0	COG0226@1|root,COG0226@2|Bacteria,46SP0@74201|Verrucomicrobia,3K734@414999|Opitutae	414999|Opitutae	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
WLSH3_k127_5344574_15	768679.TTX_0747	2.127e-13	81.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
WLSH3_k127_5344574_4	342451.SSP0028	5.751e-71	249.0	COG0863@1|root,COG0863@2|Bacteria,1VC9K@1239|Firmicutes,4HSVW@91061|Bacilli	91061|Bacilli	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
WLSH3_k127_5344574_21	660470.Theba_0404	2.135e-08	65.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_5344574_17	35754.JNYJ01000047_gene3594	6.425e-11	78.0	COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4DBZ4@85008|Micromonosporales	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,SpvB
WLSH3_k127_5344574_9	398512.JQKC01000004_gene5270	1.104e-33	153.0	COG2957@1|root,COG3055@1|root,COG2957@2|Bacteria,COG3055@2|Bacteria,1V8SQ@1239|Firmicutes,25BH8@186801|Clostridia,3WPI3@541000|Ruminococcaceae	186801|Clostridia	E	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
WLSH3_k127_5379041_6	643648.Slip_0831	4.5e-42	165.0	COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,25NSU@186801|Clostridia,42K8T@68298|Syntrophomonadaceae	186801|Clostridia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
WLSH3_k127_5379041_0	420247.Msm_1164	1.132e-119	399.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,23NMZ@183925|Methanobacteria	183925|Methanobacteria	J	PFAM GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
WLSH3_k127_5379041_4	760568.Desku_1009	2.08e-50	185.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,2620R@186807|Peptococcaceae	186801|Clostridia	S	DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
WLSH3_k127_5379041_1	1041930.Mtc_0048	8.744e-88	299.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
WLSH3_k127_5379041_2	1151117.AJLF01000001_gene866	5.618e-63	222.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
WLSH3_k127_5379041_12	490899.DKAM_1330	8.843e-15	80.0	COG1325@1|root,arCOG01042@2157|Archaea,2XQSI@28889|Crenarchaeota	28889|Crenarchaeota	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
WLSH3_k127_5379041_10	269797.Mbar_A2501	1.274e-16	89.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,2N9T6@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
WLSH3_k127_5379041_13	693661.Arcve_1047	9.245e-09	61.0	COG1369@1|root,arCOG01365@2157|Archaea,2Y7CZ@28890|Euryarchaeota,246I3@183980|Archaeoglobi	183980|Archaeoglobi	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
WLSH3_k127_5379041_11	444157.Tneu_1283	3.248e-15	81.0	COG1310@1|root,arCOG01138@2157|Archaea,2XRGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
WLSH3_k127_5379041_8	1183377.Py04_1387	3.547e-22	102.0	COG1522@1|root,arCOG01580@2157|Archaea,2XYWZ@28890|Euryarchaeota,24443@183968|Thermococci	183968|Thermococci	K	Homeodomain-like domain	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_AsnC-type
WLSH3_k127_5379041_3	673860.AciM339_0772	4.981e-56	207.0	COG3294@1|root,arCOG04230@2157|Archaea,2XURZ@28890|Euryarchaeota,3F2ZC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
WLSH3_k127_5379041_5	1121918.ARWE01000001_gene3370	4.976e-44	171.0	COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria	1224|Proteobacteria	P	iron permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
WLSH3_k127_5379041_14	1300150.EMQU_2124	3.972e-08	60.0	COG0454@1|root,COG0456@2|Bacteria,1V7GR@1239|Firmicutes,4HJ11@91061|Bacilli,4B0FF@81852|Enterococcaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
WLSH3_k127_5379041_7	743719.PaelaDRAFT_3980	5.895e-42	160.0	COG0454@1|root,COG0456@2|Bacteria,1V2CK@1239|Firmicutes,4HGP5@91061|Bacilli,26WI0@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yyaR	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_5379041_9	1499967.BAYZ01000041_gene2400	9.738e-18	89.0	COG2405@1|root,COG2405@2|Bacteria	1499967.BAYZ01000041_gene2400|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5429129_20	679926.Mpet_1131	0.0001766	51.0	arCOG04915@1|root,arCOG04915@2157|Archaea,2Y3CG@28890|Euryarchaeota,2NAQQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5429129_17	679926.Mpet_2434	1.158e-05	55.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
WLSH3_k127_5429129_16	1033806.HTIA_1328	1.261e-06	59.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
WLSH3_k127_5429129_18	797299.HALLA_12310	9.782e-05	53.0	COG3428@1|root,arCOG04619@2157|Archaea,2XU23@28890|Euryarchaeota,23T8S@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
WLSH3_k127_5429129_5	324057.Pjdr2_4393	4.027e-36	153.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli,26RUX@186822|Paenibacillaceae	91061|Bacilli	P	Arsenical pump membrane protein	arsB_2	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	CitMHS
WLSH3_k127_5429129_7	929506.CbC4_2451	9.401e-27	121.0	COG1082@1|root,COG1082@2|Bacteria,1V56C@1239|Firmicutes,24D55@186801|Clostridia,36I65@31979|Clostridiaceae	186801|Clostridia	L	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_5429129_1	485913.Krac_3682	6.126e-172	549.0	COG0673@1|root,COG0673@2|Bacteria,2G7RI@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
WLSH3_k127_5429129_12	877455.Metbo_1985	1.047e-12	78.0	COG0311@1|root,arCOG00034@2157|Archaea	2157|Archaea	F	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
WLSH3_k127_5429129_2	1394178.AWOO02000081_gene2191	8.96e-75	267.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4EKR6@85012|Streptosporangiales	201174|Actinobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
WLSH3_k127_5429129_14	401526.TcarDRAFT_0836	2.819e-07	55.0	COG1977@1|root,COG1977@2|Bacteria,1VIUV@1239|Firmicutes,4H5UH@909932|Negativicutes	909932|Negativicutes	H	Mut7-C ubiquitin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
WLSH3_k127_5429129_19	1121448.DGI_2732	0.0001145	48.0	COG1977@1|root,COG1977@2|Bacteria,1NH6M@1224|Proteobacteria,42X05@68525|delta/epsilon subdivisions,2WSK5@28221|Deltaproteobacteria,2MD55@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM ThiamineS	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
WLSH3_k127_5429129_0	1121468.AUBR01000023_gene2759	1.87e-185	597.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42FB7@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_5429129_13	497964.CfE428DRAFT_5669	2.006e-11	74.0	COG4285@1|root,COG4285@2|Bacteria,46V2C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Biotin-protein ligase, N terminal	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
WLSH3_k127_5429129_8	646529.Desaci_0681	2.869e-26	115.0	COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes	1239|Firmicutes	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
WLSH3_k127_5429129_4	1137281.D778_02447	5.287e-38	151.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1HX52@117743|Flavobacteriia	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
WLSH3_k127_5429129_9	1041930.Mtc_0543	1.509e-25	119.0	COG0438@1|root,arCOG01411@2157|Archaea,2Y8C1@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
WLSH3_k127_5429129_3	1499967.BAYZ01000085_gene5186	9.122e-60	220.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbmF	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
WLSH3_k127_5429129_6	679926.Mpet_0215	2.707e-30	123.0	COG1669@1|root,arCOG01206@2157|Archaea	2157|Archaea	M	PFAM DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
WLSH3_k127_5429129_10	1173022.Cri9333_1565	9.182e-20	89.0	COG2361@1|root,COG2361@2|Bacteria,1G7XA@1117|Cyanobacteria,1HCYZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
WLSH3_k127_5429129_11	411477.PARMER_01066	4.25e-17	83.0	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,2FPSJ@200643|Bacteroidia,2308M@171551|Porphyromonadaceae	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5456264_26	390874.Tpet_1155	1.821e-08	61.0	COG0419@1|root,COG0419@2|Bacteria,2GC4P@200918|Thermotogae	200918|Thermotogae	L	PFAM SMC domain protein	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_23,SbcCD_C
WLSH3_k127_5456264_23	42256.RradSPS_2355	1.522e-10	73.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	-	-	3.1.1.53	ko:K03547,ko:K05970	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Metallophos,Metallophos_2
WLSH3_k127_5456264_3	1095769.CAHF01000005_gene1567	4.154e-108	371.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853,DUF87,PLDc_2
WLSH3_k127_5456264_25	479434.Sthe_1514	1.069e-09	68.0	COG2220@1|root,COG2220@2|Bacteria,2G6KN@200795|Chloroflexi,27XZY@189775|Thermomicrobia	189775|Thermomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
WLSH3_k127_5456264_24	269797.Mbar_A2034	2.941e-10	66.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,2NB8N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5456264_8	192952.MM_1219	2.443e-76	269.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
WLSH3_k127_5456264_10	529709.PYCH_16080	6.835e-65	245.0	COG0343@1|root,COG1549@1|root,arCOG00989@2157|Archaea,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,243P6@183968|Thermococci	183968|Thermococci	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT_C2
WLSH3_k127_5456264_1	1459636.NTE_02924	9.534e-174	576.0	COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
WLSH3_k127_5456264_20	990073.ATHU01000001_gene1302	8.313e-16	82.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Belongs to the thioredoxin family	trx2	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH3_k127_5456264_19	990073.ATHU01000001_gene1302	5.482e-21	97.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Belongs to the thioredoxin family	trx2	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
WLSH3_k127_5456264_15	439481.Aboo_0961	5.215e-31	128.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,3F38H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
WLSH3_k127_5456264_13	1235279.C772_02070	2.843e-42	169.0	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,4HA5I@91061|Bacilli,26E7T@186818|Planococcaceae	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_5456264_22	579137.Metvu_0468	6.456e-11	72.0	COG0327@1|root,arCOG04454@2157|Archaea,2XT5G@28890|Euryarchaeota,23QHY@183939|Methanococci	183939|Methanococci	S	NIF3 (NGG1p interacting factor 3)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
WLSH3_k127_5456264_12	573063.Metin_0748	2.128e-51	193.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23QKP@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
WLSH3_k127_5456264_9	391623.TERMP_01834	6.781e-74	254.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
WLSH3_k127_5456264_21	272557.APE_1495a	7.651e-12	68.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
WLSH3_k127_5456264_4	1128421.JAGA01000003_gene3228	2.82e-107	357.0	COG0604@1|root,COG0604@2|Bacteria,2NP5I@2323|unclassified Bacteria	2|Bacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_5456264_16	694440.JOMF01000005_gene198	8.012e-29	118.0	COG0760@1|root,arCOG07441@2157|Archaea	2157|Archaea	G	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
WLSH3_k127_5456264_2	589924.Ferp_1532	3.211e-153	492.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,245YC@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
WLSH3_k127_5456264_5	1051632.TPY_1071	2.696e-104	346.0	COG1830@1|root,COG1830@2|Bacteria,1TR4S@1239|Firmicutes,24CYU@186801|Clostridia	186801|Clostridia	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
WLSH3_k127_5456264_6	1343739.PAP_08445	1.719e-103	345.0	COG2820@1|root,arCOG01324@2157|Archaea,2XSWN@28890|Euryarchaeota,243RY@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
WLSH3_k127_5456264_0	573063.Metin_0249	1.97e-188	606.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,23Q3J@183939|Methanococci	183939|Methanococci	E	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
WLSH3_k127_5456264_17	999630.TUZN_0678	1.148e-28	119.0	COG0727@1|root,arCOG02579@2157|Archaea,2XR8B@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WLSH3_k127_5456264_11	1157490.EL26_05445	5.095e-55	203.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,4HB6B@91061|Bacilli,278J9@186823|Alicyclobacillaceae	91061|Bacilli	S	DNA polymerase alpha chain like domain	php	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
WLSH3_k127_5456264_14	387631.Asulf_01798	1.485e-34	144.0	COG2159@1|root,arCOG01931@2157|Archaea,2XV9F@28890|Euryarchaeota	28890|Euryarchaeota	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
WLSH3_k127_5456264_18	246969.TAM4_1973	3.708e-28	119.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,2447N@183968|Thermococci	183968|Thermococci	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
WLSH3_k127_5456264_28	335283.Neut_0417	2.6e-05	53.0	COG1765@1|root,COG1765@2|Bacteria,1QXHR@1224|Proteobacteria,2WH4K@28216|Betaproteobacteria,373XY@32003|Nitrosomonadales	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
WLSH3_k127_5456264_7	411490.ANACAC_02754	5.139e-98	331.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_5456264_27	523850.TON_0187	1.562e-07	57.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,2448C@183968|Thermococci	183968|Thermococci	L	UPF0292 protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
WLSH3_k127_5557822_12	304371.MCP_1615	6.142e-45	184.0	COG2202@1|root,arCOG02353@1|root,arCOG02353@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_5557822_25	1117108.PAALTS15_19913	5.527e-18	87.0	COG0640@1|root,COG0640@2|Bacteria,1VFNB@1239|Firmicutes,4HQ6G@91061|Bacilli,2751E@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	cadC	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
WLSH3_k127_5557822_1	1220534.B655_1154	1.998e-151	500.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
WLSH3_k127_5557822_9	765420.OSCT_0964	2.882e-58	214.0	COG1131@1|root,COG1131@2|Bacteria,2G6KA@200795|Chloroflexi	200795|Chloroflexi	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_5557822_23	521011.Mpal_2756	9.046e-22	103.0	COG0642@1|root,arCOG02385@1|root,arCOG02385@2157|Archaea,arCOG06192@2157|Archaea	2157|Archaea	T	TIGRFAM PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_5557822_6	1094980.Mpsy_1403	9.098e-73	259.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
WLSH3_k127_5557822_11	679926.Mpet_1138	3.729e-46	191.0	COG0642@1|root,COG2202@1|root,arCOG06712@1|root,arCOG06940@1|root,arCOG06193@2157|Archaea,arCOG06712@2157|Archaea,arCOG06918@2157|Archaea,arCOG06940@2157|Archaea,2XWN9@28890|Euryarchaeota,2NANJ@224756|Methanomicrobia	2157|Archaea	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,PocR,Response_reg
WLSH3_k127_5557822_5	1408473.JHXO01000010_gene3609	1.033e-105	351.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FX64@200643|Bacteroidia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_5557822_31	38654.XP_006015124.1	0.0001486	52.0	KOG4804@1|root,KOG4804@2759|Eukaryota,3A13N@33154|Opisthokonta,3BRRI@33208|Metazoa,3CV87@33213|Bilateria,4878Z@7711|Chordata,49914@7742|Vertebrata	33208|Metazoa	T	transmembrane protein 86B	TMEM86B	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006662,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0012505,GO:0016020,GO:0016787,GO:0016801,GO:0016803,GO:0018904,GO:0019637,GO:0031984,GO:0036151,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046470,GO:0046485,GO:0046486,GO:0047408,GO:0047409,GO:0071704,GO:0097164,GO:0098827,GO:1901564	3.3.2.2	ko:K18575	ko00565,map00565	-	R02745,R03415	RC00199	ko00000,ko00001,ko01000	-	-	-	YhhN
WLSH3_k127_5557822_20	247490.KSU1_C1639	1.673e-28	121.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
WLSH3_k127_5557822_17	1038866.KB902801_gene6914	7.836e-31	125.0	COG3602@1|root,COG3602@2|Bacteria,1MZKQ@1224|Proteobacteria,2U85U@28211|Alphaproteobacteria,3JZ4P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ACT domain	-	-	-	ko:K09964	-	-	-	-	ko00000	-	-	-	ACT_3,ACT_7
WLSH3_k127_5557822_14	580331.Thit_1604	1.474e-34	138.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,42G3X@68295|Thermoanaerobacterales	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,Nitroreductase
WLSH3_k127_5557822_4	1232437.KL661965_gene3264	1.278e-114	385.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria,42WP6@68525|delta/epsilon subdivisions,2WSCA@28221|Deltaproteobacteria,2MNZT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Ethanolamine utilisation protein EutA	-	-	-	-	-	-	-	-	-	-	-	-	EutA
WLSH3_k127_5557822_7	469382.Hbor_09240	1.782e-67	244.0	COG3608@1|root,arCOG02890@2157|Archaea,2XUVB@28890|Euryarchaeota,23UWM@183963|Halobacteria	183963|Halobacteria	S	Deacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
WLSH3_k127_5557822_15	351160.RCIX604	1.717e-32	145.0	COG0642@1|root,COG2202@1|root,arCOG06219@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,HisKA_2,HisKA_7TM,PAS,PAS_4,PAS_8,PAS_9,Response_reg
WLSH3_k127_5557822_29	479434.Sthe_0124	1.199e-06	61.0	COG0477@1|root,COG2814@2|Bacteria,2G6DM@200795|Chloroflexi,27YS9@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
WLSH3_k127_5557822_26	673860.AciM339_0279	7.814e-18	93.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y72Y@28890|Euryarchaeota,3F3AT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
WLSH3_k127_5557822_27	760568.Desku_0061	5.06e-16	89.0	COG1600@1|root,COG1600@2|Bacteria,1TP6Q@1239|Firmicutes,24B04@186801|Clostridia,2670T@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM iron-sulfur cluster binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_16,Fer4_7
WLSH3_k127_5557822_18	868131.MSWAN_0193	8.491e-31	128.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
WLSH3_k127_5557822_8	1173020.Cha6605_0959	2.653e-66	236.0	COG0508@1|root,COG0508@2|Bacteria,1G4MH@1117|Cyanobacteria	1117|Cyanobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
WLSH3_k127_5557822_2	290397.Adeh_2295	6.455e-150	484.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,42Y9Q@68525|delta/epsilon subdivisions,2WTQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WLSH3_k127_5557822_0	1121289.JHVL01000013_gene1638	1.997e-219	690.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
WLSH3_k127_5557822_16	386456.JQKN01000001_gene2324	1.476e-31	132.0	arCOG02703@1|root,arCOG02703@2157|Archaea,2XY9N@28890|Euryarchaeota	28890|Euryarchaeota	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_5557822_21	926550.CLDAP_07730	6.211e-24	108.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	MA20_10010	-	-	-	-	-	-	-	-	-	-	-	TetR_N
WLSH3_k127_5557822_22	673860.AciM339_0279	1.591e-22	102.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y72Y@28890|Euryarchaeota,3F3AT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
WLSH3_k127_5557822_13	1280692.AUJL01000024_gene3408	3.896e-42	158.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia,36M8N@31979|Clostridiaceae	186801|Clostridia	I	PFAM MaoC domain protein dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
WLSH3_k127_5557822_10	1131730.BAVI_15712	3.427e-46	171.0	COG0332@1|root,COG0332@2|Bacteria,1TRHZ@1239|Firmicutes,4HDJ2@91061|Bacilli,1ZB47@1386|Bacillus	91061|Bacilli	I	COG0332 3-oxoacyl- acyl-carrier-protein synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
WLSH3_k127_5557822_24	714961.BFZC1_09030	4.607e-19	91.0	COG0332@1|root,COG0332@2|Bacteria,1TRHZ@1239|Firmicutes,4HDJ2@91061|Bacilli,3IWJR@400634|Lysinibacillus	91061|Bacilli	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
WLSH3_k127_5557822_28	1459636.NTE_01286	2.673e-09	68.0	COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_5557822_3	660470.Theba_2510	6.886e-123	402.0	COG1028@1|root,COG1028@2|Bacteria,2GCF7@200918|Thermotogae	200918|Thermotogae	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WLSH3_k127_5557822_19	484019.THA_706	7.22e-29	117.0	COG1233@1|root,COG1233@2|Bacteria,2GDP7@200918|Thermotogae	200918|Thermotogae	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
WLSH3_k127_556739_1	1089552.KI911559_gene541	5.949e-45	170.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,2JRV2@204441|Rhodospirillales	204441|Rhodospirillales	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
WLSH3_k127_556739_0	457570.Nther_1921	1.339e-101	355.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
WLSH3_k127_574122_16	269797.Mbar_A0475	1.36e-16	81.0	COG1983@1|root,arCOG03455@2157|Archaea,2Y1D0@28890|Euryarchaeota,2NBBJ@224756|Methanomicrobia	224756|Methanomicrobia	K	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
WLSH3_k127_574122_18	1293048.CBMB010000010_gene3706	6.191e-07	61.0	COG2041@1|root,arCOG00266@2157|Archaea,2XUVR@28890|Euryarchaeota,23SMX@183963|Halobacteria	183963|Halobacteria	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
WLSH3_k127_574122_4	1379698.RBG1_1C00001G1614	1.336e-101	344.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
WLSH3_k127_574122_19	1445613.JALM01000073_gene6839	1.676e-06	54.0	COG1846@1|root,COG1846@2|Bacteria,2IJQZ@201174|Actinobacteria,4EBEY@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
WLSH3_k127_574122_8	304371.MCP_1382	5.191e-63	224.0	COG2195@1|root,arCOG12582@2157|Archaea	2157|Archaea	E	tripeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_574122_22	742818.HMPREF9451_01480	0.0003843	49.0	COG0454@1|root,COG0533@1|root,COG1214@1|root,COG0456@2|Bacteria,COG0533@2|Bacteria,COG1214@2|Bacteria,2GJ98@201174|Actinobacteria,4CUKY@84998|Coriobacteriia	84998|Coriobacteriia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
WLSH3_k127_574122_5	1047013.AQSP01000144_gene915	6.289e-83	282.0	COG0492@1|root,COG0822@1|root,COG0492@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_oxidored,FeS_assembly_P,NifU_N,Pyr_redox_2,cNMP_binding
WLSH3_k127_574122_0	1047013.AQSP01000144_gene916	4.235e-175	556.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
WLSH3_k127_574122_15	1047013.AQSP01000144_gene918	1.038e-25	108.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
WLSH3_k127_574122_3	1303518.CCALI_00439	9.749e-106	355.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	MA20_31690	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_574122_1	1379698.RBG1_1C00001G1193	1.692e-115	384.0	COG0006@1|root,COG0006@2|Bacteria,2NQIC@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
WLSH3_k127_574122_10	1353529.M899_2055	3.041e-61	234.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2MSTI@213481|Bdellovibrionales,2WJDZ@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
WLSH3_k127_574122_17	456442.Mboo_0643	2.758e-11	76.0	COG2208@1|root,arCOG02362@1|root,arCOG02362@2157|Archaea,arCOG06893@2157|Archaea	2157|Archaea	KT	stage II sporulation	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
WLSH3_k127_574122_21	7739.XP_002612768.1	0.0001478	55.0	COG0457@1|root,KOG0548@2759|Eukaryota,39NJK@33154|Opisthokonta,3CQ3T@33208|Metazoa,3DEBE@33213|Bilateria,48RPG@7711|Chordata	2759|Eukaryota	O	TPR repeat	-	-	-	ko:K14861	-	-	-	-	ko00000,ko03009	-	-	-	DUF294,TPR_10,TPR_12,TPR_7,TPR_8
WLSH3_k127_574122_9	58123.JOFJ01000002_gene2594	6.765e-62	228.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4EGFY@85012|Streptosporangiales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
WLSH3_k127_574122_11	760568.Desku_2713	5.041e-55	200.0	COG5012@1|root,COG5012@2|Bacteria,1V33W@1239|Firmicutes,24J77@186801|Clostridia,266X4@186807|Peptococcaceae	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
WLSH3_k127_574122_2	768710.DesyoDRAFT_3377	1.399e-112	382.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
WLSH3_k127_574122_7	456442.Mboo_1043	7.884e-65	235.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
WLSH3_k127_574122_13	304371.MCP_1615	2.992e-31	139.0	COG2202@1|root,arCOG02353@1|root,arCOG02353@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WLSH3_k127_574122_14	572546.Arcpr_1285	7.55e-29	124.0	COG1180@1|root,arCOG00952@2157|Archaea,2XW90@28890|Euryarchaeota,2473U@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_574122_6	269797.Mbar_A2503	4.214e-71	247.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
WLSH3_k127_574122_12	399549.Msed_0692	2.256e-50	190.0	COG0189@1|root,arCOG01589@2157|Archaea,2XQGE@28889|Crenarchaeota	28889|Crenarchaeota	H	RimK domain protein ATP-grasp	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
WLSH3_k127_5780210_0	1214166.ALLG01000016_gene869	2.278e-18	100.0	COG0433@1|root,COG0433@2|Bacteria,1TQPR@1239|Firmicutes,4HCUM@91061|Bacilli,1WTU2@1307|Streptococcus suis	91061|Bacilli	S	Type IV secretion-system coupling protein DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
WLSH3_k127_5800141_0	1121430.JMLG01000006_gene1717	2.105e-240	770.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,260PA@186807|Peptococcaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
WLSH3_k127_5800141_6	192952.MM_0718	1.25e-75	269.0	COG0644@1|root,arCOG00570@2157|Archaea,2XWXQ@28890|Euryarchaeota,2N9RD@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
WLSH3_k127_5800141_11	877455.Metbo_0822	3.205e-46	180.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23NK4@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
WLSH3_k127_5800141_4	1379698.RBG1_1C00001G1133	5.185e-83	287.0	COG1575@1|root,COG1575@2|Bacteria,2NPNN@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
WLSH3_k127_5800141_7	1089553.Tph_c19580	8.417e-72	258.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
WLSH3_k127_5800141_5	635013.TherJR_1222	5.048e-79	288.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,266U6@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
WLSH3_k127_5800141_12	399549.Msed_2012	2.721e-37	161.0	COG0377@1|root,arCOG01554@2157|Archaea,2XQCS@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the complex I 20 kDa subunit family	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
WLSH3_k127_5800141_15	1185876.BN8_00327	3.413e-08	61.0	COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,47PRF@768503|Cytophagia	976|Bacteroidetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
WLSH3_k127_5800141_17	1131266.ARWQ01000015_gene760	2.535e-06	57.0	COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
WLSH3_k127_5800141_16	1123373.ATXI01000012_gene948	9.747e-08	57.0	COG0713@1|root,COG0713@2|Bacteria,2GHZC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
WLSH3_k127_5800141_13	289376.THEYE_A1122	4.832e-18	91.0	COG0852@1|root,COG0852@2|Bacteria,3J168@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
WLSH3_k127_5800141_8	1196322.A370_05883	1.179e-60	224.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,24EDV@186801|Clostridia,36UKX@31979|Clostridiaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
WLSH3_k127_5800141_9	552811.Dehly_0835	4.316e-54	206.0	COG1005@1|root,COG1005@2|Bacteria,2G60S@200795|Chloroflexi,34CTC@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
WLSH3_k127_5800141_14	330214.NIDE0231	9.452e-17	85.0	COG1143@1|root,COG1143@2|Bacteria,3J0N0@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
WLSH3_k127_5800141_3	436308.Nmar_0284	1.762e-85	301.0	COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota	651137|Thaumarchaeota	C	plastoquinone (complex I)	-	-	1.6.5.3	ko:K00342,ko:K12137,ko:K12141	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
WLSH3_k127_5800141_1	555779.Dthio_PD1228	3.403e-112	389.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MG3C@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
WLSH3_k127_5800141_2	118005.AWNK01000008_gene424	1.802e-88	311.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
WLSH3_k127_5800141_10	436308.Nmar_0286	2.862e-46	181.0	COG1007@1|root,arCOG01540@2157|Archaea,41SDU@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase subunit 2 (Chain N)	-	-	1.5.98.3	ko:K22169	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Proton_antipo_M
WLSH3_k127_5831568_1	1089553.Tph_c04360	6.804e-93	321.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,42EZ2@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
WLSH3_k127_5831568_2	1280673.AUJJ01000001_gene2339	1.356e-16	89.0	COG0619@1|root,COG0619@2|Bacteria,1TPMV@1239|Firmicutes,24AYK@186801|Clostridia,4BX4Q@830|Butyrivibrio	186801|Clostridia	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
WLSH3_k127_5831568_0	390874.Tpet_1772	4.792e-191	620.0	COG1743@1|root,COG1743@2|Bacteria	2|Bacteria	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156,N6_N4_Mtase
WLSH3_k127_5885723_1	1227352.C173_03424	6.094e-17	89.0	COG0500@1|root,COG2226@2|Bacteria,1V7TR@1239|Firmicutes,4HJ1N@91061|Bacilli,26UAU@186822|Paenibacillaceae	91061|Bacilli	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
WLSH3_k127_5885723_0	926569.ANT_03680	2.645e-23	111.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_5926549_5	877455.Metbo_1600	1.913e-05	59.0	arCOG02487@1|root,arCOG02555@1|root,arCOG03270@1|root,arCOG02487@2157|Archaea,arCOG02555@2157|Archaea,arCOG03270@2157|Archaea,2Y7UE@28890|Euryarchaeota,23PA5@183925|Methanobacteria	183925|Methanobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
WLSH3_k127_5926549_4	634497.HAH_1639	1.609e-08	67.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
WLSH3_k127_5926549_0	195522.BD01_1777	2.683e-99	333.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WLSH3_k127_5926549_1	765420.OSCT_1333	7.326e-39	161.0	COG1721@1|root,COG1721@2|Bacteria,2G7PU@200795|Chloroflexi,375DS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WLSH3_k127_5926549_2	1041930.Mtc_1997	4.702e-14	86.0	COG1297@1|root,arCOG04807@2157|Archaea	2157|Archaea	S	Oligopeptide transporter OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
WLSH3_k127_5926549_6	1220534.B655_0098	0.0002695	49.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,23PVJ@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
WLSH3_k127_5926549_3	1227352.C173_03424	4.488e-11	68.0	COG0500@1|root,COG2226@2|Bacteria,1V7TR@1239|Firmicutes,4HJ1N@91061|Bacilli,26UAU@186822|Paenibacillaceae	91061|Bacilli	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
WLSH3_k127_5930002_1	401526.TcarDRAFT_1837	1.271e-91	308.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H2QE@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
WLSH3_k127_5930002_0	484770.UFO1_3311	1.239e-116	388.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4H27J@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
WLSH3_k127_5930002_2	1521187.JPIM01000167_gene1704	1.311e-22	110.0	COG0457@1|root,COG1404@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
WLSH3_k127_5939565_0	415426.Hbut_1294	2.253e-25	109.0	COG0185@1|root,arCOG04099@2157|Archaea,2XQBR@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
WLSH3_k127_5939565_1	545695.TREAZ_3271	2.406e-07	59.0	COG0457@1|root,COG0457@2|Bacteria,2J780@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
WLSH3_k127_5939565_3	399550.Smar_1446	0.0008535	47.0	COG5625@1|root,arCOG04189@2157|Archaea,2XQWI@28889|Crenarchaeota	28889|Crenarchaeota	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_5939565_2	1232447.BAHW02000052_gene3117	3.583e-06	49.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia	186801|Clostridia	C	electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
WLSH3_k127_5980879_1	2423.NA23_0208440	1.079e-08	66.0	COG0747@1|root,COG0747@2|Bacteria,2GC1T@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
WLSH3_k127_5980879_0	266835.14025828	2.926e-09	70.0	COG0747@1|root,COG0747@2|Bacteria,1NQYF@1224|Proteobacteria,2UQBX@28211|Alphaproteobacteria,43PQY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_5980879_2	867903.ThesuDRAFT_01860	1.173e-08	68.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,3WD2D@538999|Clostridiales incertae sedis	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_6075396_4	644282.Deba_1896	2.424e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
WLSH3_k127_6075396_1	224325.AF_1350	4.857e-32	136.0	COG0491@1|root,arCOG00504@2157|Archaea,2XYKN@28890|Euryarchaeota,246C0@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_6075396_0	673860.AciM339_0352	1.254e-99	337.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,3F37E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
WLSH3_k127_6075396_2	509191.AEDB02000033_gene5135	1.981e-23	104.0	2DMZP@1|root,32UMQ@2|Bacteria,1VHU7@1239|Firmicutes,24QKJ@186801|Clostridia,3WKPR@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
WLSH3_k127_6075396_3	1033734.CAET01000022_gene1286	4.982e-13	77.0	COG0526@1|root,COG0526@2|Bacteria,1V2DU@1239|Firmicutes,4HGQZ@91061|Bacilli,1ZG9D@1386|Bacillus	91061|Bacilli	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_9
WLSH3_k127_6075396_5	67315.JOBD01000007_gene3287	0.000607	47.0	COG4106@1|root,COG4106@2|Bacteria,2GJMG@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	tam	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
WLSH3_k127_6432391_0	523845.AQXV01000047_gene808	6.826e-41	167.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,23Q75@183939|Methanococci	183939|Methanococci	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
WLSH3_k127_6566864_5	1125863.JAFN01000001_gene201	2.437e-14	79.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WR88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
WLSH3_k127_6566864_7	1042877.GQS_09815	6.107e-06	54.0	arCOG04079@1|root,arCOG04079@2157|Archaea,2Y184@28890|Euryarchaeota,2448K@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6566864_8	272557.APE_0297	7.034e-06	55.0	arCOG00743@1|root,arCOG00743@2157|Archaea,2XR97@28889|Crenarchaeota	28889|Crenarchaeota	K	transcription regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6566864_1	1121346.KB899815_gene1859	7.249e-123	403.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4HATT@91061|Bacilli,26SI9@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
WLSH3_k127_6566864_2	635013.TherJR_2600	1.548e-87	306.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
WLSH3_k127_6566864_6	1343739.PAP_03275	4.425e-11	67.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
WLSH3_k127_6566864_9	1128421.JAGA01000002_gene273	0.0001042	53.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	Prenyltrans,SQHop_cyclase_C
WLSH3_k127_6566864_3	693661.Arcve_1502	1.272e-77	283.0	COG3276@1|root,arCOG01562@2157|Archaea,2XTHU@28890|Euryarchaeota,246PY@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM Protein synthesis factor, GTP-binding	-	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	AlbA_2,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
WLSH3_k127_6566864_0	391623.TERMP_00743	3.386e-124	413.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,242NX@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_6566864_4	69014.TK0499	2.041e-75	270.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,242W4@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_6730691_1	1123252.ATZF01000002_gene2679	2.016e-11	77.0	COG0675@1|root,COG0675@2|Bacteria,1TT4J@1239|Firmicutes,4HEKB@91061|Bacilli	91061|Bacilli	L	Putative transposase DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
WLSH3_k127_6730691_0	861299.J421_0701	1.816e-55	199.0	COG0563@1|root,COG0563@2|Bacteria	2|Bacteria	F	adenylate kinase activity	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_18,ADK,ADK_lid
WLSH3_k127_6859438_11	453591.Igni_0442	2.932e-34	135.0	COG1759@1|root,arCOG04346@2157|Archaea,2XPSG@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
WLSH3_k127_6859438_3	572546.Arcpr_1231	9.088e-137	443.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,246UQ@183980|Archaeoglobi	183980|Archaeoglobi	F	IMP biosynthesis enzyme PurP domain protein	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
WLSH3_k127_6859438_9	698737.SLGD_01808	2.794e-64	231.0	COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,4H9U8@91061|Bacilli,4GXTP@90964|Staphylococcaceae	91061|Bacilli	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
WLSH3_k127_6859438_10	648996.Theam_0720	2.35e-63	225.0	COG0047@1|root,COG0047@2|Bacteria,2G3Q5@200783|Aquificae	200783|Aquificae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
WLSH3_k127_6859438_1	649747.HMPREF0083_03248	2.521e-162	538.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,4HB3N@91061|Bacilli,26RX8@186822|Paenibacillaceae	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WLSH3_k127_6859438_12	1041930.Mtc_0528	4.117e-34	148.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
WLSH3_k127_6859438_7	420247.Msm_1039	1.388e-79	283.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,23NW1@183925|Methanobacteria	183925|Methanobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WLSH3_k127_6859438_5	647113.Metok_0590	2.188e-100	342.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,23Q0W@183939|Methanococci	183939|Methanococci	F	Glycinamide ribonucleotide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
WLSH3_k127_6859438_2	1131269.AQVV01000009_gene1150	9.79e-142	466.0	COG0519@1|root,COG0519@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.3.1.128,6.3.5.2	ko:K01951,ko:K03790	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002,ko03009	-	-	iLJ478.TM1820	GATase,GMP_synt_C,NAD_synthase
WLSH3_k127_6859438_6	1114959.SZMC14600_19129	5.127e-83	289.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4DZBB@85010|Pseudonocardiales	201174|Actinobacteria	BQ	Deacetylase, histone deacetylase acetoin utilization protein	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
WLSH3_k127_6859438_14	509191.AEDB02000048_gene4644	8.228e-05	53.0	COG2159@1|root,COG2159@2|Bacteria,1TRU0@1239|Firmicutes,248VZ@186801|Clostridia,3WHH4@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
WLSH3_k127_6859438_4	195522.BD01_1570	8.618e-126	422.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,242VY@183968|Thermococci	183968|Thermococci	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
WLSH3_k127_6859438_13	555088.DealDRAFT_1098	6.475e-33	139.0	COG0491@1|root,COG0491@2|Bacteria,1V62I@1239|Firmicutes,24I5E@186801|Clostridia,42JY1@68298|Syntrophomonadaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_6859438_8	401526.TcarDRAFT_1748	3.406e-68	241.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,4H4QV@909932|Negativicutes	909932|Negativicutes	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
WLSH3_k127_6859438_0	706587.Desti_3137	4.007e-174	557.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2MQ5N@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
WLSH3_k127_6932601_14	453591.Igni_0791	1.185e-17	87.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
WLSH3_k127_6932601_16	304371.MCP_0304	1.811e-13	75.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
WLSH3_k127_6932601_22	243231.GSU1263	2.929e-05	49.0	COG1534@1|root,COG1534@2|Bacteria,1Q1J9@1224|Proteobacteria,42WJ8@68525|delta/epsilon subdivisions,2WRWD@28221|Deltaproteobacteria,43V6M@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	CRS1_YhbY	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
WLSH3_k127_6932601_6	342949.PNA2_1905	6.321e-52	187.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,242ZB@183968|Thermococci	183968|Thermococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
WLSH3_k127_6932601_12	269797.Mbar_A0455	6.737e-24	104.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
WLSH3_k127_6932601_17	933801.Ahos_1287	1.138e-12	70.0	COG2167@1|root,arCOG04177@2157|Archaea,2XRC0@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
WLSH3_k127_6932601_15	243232.MJ_0049	4.25e-15	80.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23R3K@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein L31e	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
WLSH3_k127_6932601_8	519442.Huta_0998	3.027e-46	174.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,23SZE@183963|Halobacteria	183963|Halobacteria	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
WLSH3_k127_6932601_19	1041930.Mtc_0441	1.763e-09	64.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
WLSH3_k127_6932601_3	523850.TON_0592	6.222e-97	326.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
WLSH3_k127_6932601_1	1536775.H70737_28125	1.511e-106	354.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H9X8@91061|Bacilli,26S8W@186822|Paenibacillaceae	91061|Bacilli	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
WLSH3_k127_6932601_10	1293048.CBMB010000003_gene1453	6.927e-39	157.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23SW4@183963|Halobacteria	183963|Halobacteria	G	Belongs to the carbohydrate kinase PfkB family	suk	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
WLSH3_k127_6932601_0	529709.PYCH_18150	7.212e-108	361.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,242PW@183968|Thermococci	183968|Thermococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
WLSH3_k127_6932601_23	591019.Shell_1385	0.0001621	46.0	COG2443@1|root,arCOG02204@2157|Archaea	2157|Archaea	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
WLSH3_k127_6932601_21	1094980.Mpsy_1497	8.641e-09	62.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2N9MV@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
WLSH3_k127_6932601_18	224719.Abm4_0255	3.517e-12	69.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,23P3U@183925|Methanobacteria	183925|Methanobacteria	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
WLSH3_k127_6932601_7	1236689.MMALV_00450	2.112e-47	176.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,3F2N7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
WLSH3_k127_6932601_9	523845.AQXV01000048_gene606	3.773e-44	168.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,23Q2Y@183939|Methanococci	183939|Methanococci	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
WLSH3_k127_6932601_5	573064.Mefer_0704	4.099e-58	214.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23Q5D@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s,Ribosomal_L10
WLSH3_k127_6932601_11	593750.Metfor_0418	1.357e-24	107.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2N9U8@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
WLSH3_k127_6932601_4	56780.SYN_01017	1.084e-64	229.0	COG0123@1|root,COG0123@2|Bacteria,1RBR4@1224|Proteobacteria,42R2Z@68525|delta/epsilon subdivisions,2WN6H@28221|Deltaproteobacteria,2MR74@213462|Syntrophobacterales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
WLSH3_k127_6932601_20	1406840.Q763_03895	7.065e-09	63.0	COG2318@1|root,COG2318@2|Bacteria,4NNMT@976|Bacteroidetes,1I21N@117743|Flavobacteriia,2NV29@237|Flavobacterium	976|Bacteroidetes	S	Damage-inducible protein DinB	-	-	-	-	-	-	-	-	-	-	-	-	DinB
WLSH3_k127_6932601_13	316274.Haur_1599	2.326e-23	103.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_34
WLSH3_k127_6932601_2	351160.RCIX396	5.433e-101	340.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_6956971_13	368408.Tpen_1831	4.07e-44	175.0	COG2211@1|root,arCOG00146@2157|Archaea,2XSCD@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
WLSH3_k127_6956971_23	304371.MCP_2041	1.688e-11	68.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_6956971_27	42256.RradSPS_0282	8.285e-08	55.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4CQ7M@84995|Rubrobacteria	84995|Rubrobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_6956971_9	604354.TSIB_1816	4.36e-59	214.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,245B1@183968|Thermococci	183968|Thermococci	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
WLSH3_k127_6956971_3	1121472.AQWN01000007_gene1130	2.842e-116	383.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
WLSH3_k127_6956971_5	555079.Toce_2031	3.235e-96	325.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
WLSH3_k127_6956971_25	1382315.JPOI01000001_gene1925	4.471e-10	67.0	COG0346@1|root,COG0346@2|Bacteria,1V6SC@1239|Firmicutes,4HCP5@91061|Bacilli,1WGBJ@129337|Geobacillus	91061|Bacilli	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
WLSH3_k127_6956971_16	224325.AF_1066	5.429e-42	167.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,245QK@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
WLSH3_k127_6956971_8	351160.RCIX2721	4.572e-67	234.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,2N9M4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
WLSH3_k127_6956971_21	690850.Desaf_0247	1.541e-32	138.0	COG0697@1|root,COG0697@2|Bacteria,1NCEQ@1224|Proteobacteria,43AZZ@68525|delta/epsilon subdivisions,2X6E2@28221|Deltaproteobacteria,2MH1V@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_6956971_22	604354.TSIB_0983	1.557e-15	87.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
WLSH3_k127_6956971_11	644281.MFS40622_1299	1.455e-47	182.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_6956971_12	335541.Swol_1704	1.237e-45	172.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia,42KMI@68298|Syntrophomonadaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6
WLSH3_k127_6956971_19	269797.Mbar_A0254	5.745e-38	155.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
WLSH3_k127_6956971_24	2045.KR76_05140	4.353e-11	69.0	COG2164@1|root,COG2164@2|Bacteria,2I8JP@201174|Actinobacteria,4DSWZ@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF3830)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3830
WLSH3_k127_6956971_10	865861.AZSU01000001_gene552	1.455e-56	213.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,36E1G@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the peptidase M24B family	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
WLSH3_k127_6956971_6	639282.DEFDS_1066	2.599e-76	262.0	COG0410@1|root,COG0410@2|Bacteria,2GEK0@200930|Deferribacteres	200930|Deferribacteres	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
WLSH3_k127_6956971_7	374847.Kcr_0826	2.922e-70	246.0	COG0411@1|root,arCOG00926@2157|Archaea	2157|Archaea	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
WLSH3_k127_6956971_1	574087.Acear_1487	3.505e-169	561.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_6956971_15	555088.DealDRAFT_0574	1.556e-43	173.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,42JQE@68298|Syntrophomonadaceae	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998,ko:K11961	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
WLSH3_k127_6956971_17	1101189.AQUO01000001_gene1513	6.105e-41	163.0	COG0559@1|root,COG0559@2|Bacteria,1PH01@1224|Proteobacteria,2V7JN@28211|Alphaproteobacteria,2PYT9@265|Paracoccus	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
WLSH3_k127_6956971_20	589924.Ferp_1169	2.844e-37	156.0	COG0683@1|root,arCOG01020@2157|Archaea,2XTSF@28890|Euryarchaeota,24631@183980|Archaeoglobi	28890|Euryarchaeota	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6,TAT_signal
WLSH3_k127_6956971_2	1047013.AQSP01000134_gene1369	5.016e-141	461.0	COG0403@1|root,COG0403@2|Bacteria,2NQS4@2323|unclassified Bacteria	2|Bacteria	E	Glycine cleavage system P-protein	gcvPA	-	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
WLSH3_k127_6956971_0	865861.AZSU01000003_gene2199	2.803e-177	570.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,36FTT@31979|Clostridiaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
WLSH3_k127_6956971_4	891968.Anamo_1486	3.022e-115	382.0	COG3199@1|root,COG3199@2|Bacteria,3T9RA@508458|Synergistetes	508458|Synergistetes	H	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
WLSH3_k127_6956971_26	1343739.PAP_06975	2.435e-09	68.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
WLSH3_k127_6956971_18	374847.Kcr_0495	1.16e-39	152.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_IclR,TrmB
WLSH3_k127_6956971_14	945713.IALB_3117	1.52e-43	162.0	2DTJ6@1|root,33KM6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_6956971_28	1121447.JONL01000008_gene3514	2.358e-07	59.0	COG2020@1|root,COG2020@2|Bacteria,1QE67@1224|Proteobacteria,435WA@68525|delta/epsilon subdivisions,2X9D8@28221|Deltaproteobacteria,2MCKH@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_7103415_1	1380391.JIAS01000006_gene2518	7.737e-15	87.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,2JQ2N@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_7103415_0	1123288.SOV_7c00310	9.623e-48	185.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,4H3AP@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
WLSH3_k127_7111745_2	309800.C498_03600	3.087e-16	82.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,23VIW@183963|Halobacteria	183963|Halobacteria	F	COG1437 Adenylate cyclase, class 2 (thermophilic)	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
WLSH3_k127_7111745_0	633148.Tagg_0552	4.15e-106	358.0	COG0498@1|root,arCOG01434@2157|Archaea,2XQ1A@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_7111745_1	314345.SPV1_05168	2.389e-51	184.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria	1224|Proteobacteria	FJ	deaminase	cdd	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
WLSH3_k127_7160773_1	555088.DealDRAFT_0595	1.317e-55	198.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,42KZ0@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_7160773_0	82508.K1WTS5	9.859e-134	443.0	COG0114@1|root,KOG1317@2759|Eukaryota,38GHX@33154|Opisthokonta,3NTY2@4751|Fungi,3UYYY@5204|Basidiomycota,3VCP0@5234|Tremellales	4751|Fungi	C	Fumarase C C-terminus	FUM1	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0055114,GO:0070013,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	iMM904.YPL262W,iND750.YPL262W	FumaraseC_C,Lyase_1
WLSH3_k127_7419551_13	1499967.BAYZ01000156_gene556	3.269e-07	53.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
WLSH3_k127_7419551_5	871963.Desdi_1656	4.324e-66	233.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_7419551_10	633148.Tagg_0582	3.875e-16	80.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
WLSH3_k127_7419551_9	868131.MSWAN_1349	6.735e-22	99.0	arCOG05401@1|root,arCOG05401@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7419551_14	333138.LQ50_08920	6.586e-05	55.0	COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,4HBJX@91061|Bacilli,1ZE6M@1386|Bacillus	91061|Bacilli	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
WLSH3_k127_7419551_12	521011.Mpal_0795	4.272e-14	76.0	arCOG08221@1|root,arCOG08221@2157|Archaea,2Y1Z0@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7419551_11	272557.APE_0275a	3.255e-15	77.0	COG5428@1|root,arCOG02270@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
WLSH3_k127_7419551_7	368407.Memar_2263	1.176e-34	139.0	arCOG09456@1|root,arCOG09456@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7419551_1	1499967.BAYZ01000038_gene2268	2.278e-160	514.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF608,GDE_C,Glyco_hydro_100,S6PP
WLSH3_k127_7419551_0	1408473.JHXO01000008_gene2652	4.103e-186	587.0	COG0438@1|root,COG0438@2|Bacteria,4NKIM@976|Bacteroidetes	976|Bacteroidetes	M	Pfam Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
WLSH3_k127_7419551_4	1408473.JHXO01000008_gene2653	2.835e-70	244.0	COG2120@1|root,COG2120@2|Bacteria,4NM6J@976|Bacteroidetes	976|Bacteroidetes	S	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
WLSH3_k127_7419551_8	999630.TUZN_0897	2.114e-24	106.0	COG0517@1|root,arCOG00606@2157|Archaea,2XQQK@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
WLSH3_k127_7419551_3	1150474.JQJI01000007_gene253	1.272e-80	278.0	COG2152@1|root,COG2152@2|Bacteria,2GCDD@200918|Thermotogae	200918|Thermotogae	G	PFAM glycosidase, PH1107-related	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
WLSH3_k127_7419551_2	385682.AFSL01000083_gene1143	9.779e-81	281.0	COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes,2FMEB@200643|Bacteroidia,3XJ81@558415|Marinilabiliaceae	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_7419551_6	935948.KE386495_gene1235	2.748e-47	174.0	COG0438@1|root,COG0438@2|Bacteria,1TQRQ@1239|Firmicutes,249H2@186801|Clostridia,42EVC@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WLSH3_k127_7518853_2	243231.GSU1757	0.0005446	45.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,43V7X@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_7518853_0	673860.AciM339_1556	3.091e-109	368.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,3F2ZN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_7518853_1	237368.SCABRO_00111	1.686e-81	280.0	COG1331@1|root,COG1331@2|Bacteria,2IX0N@203682|Planctomycetes	203682|Planctomycetes	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
WLSH3_k127_7542449_20	1198449.ACAM_0140	6.736e-11	65.0	arCOG04057@1|root,arCOG04057@2157|Archaea,2XSD3@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL38 family	-	-	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
WLSH3_k127_7542449_1	1056495.Calag_0014	3.782e-91	316.0	COG1236@1|root,arCOG00541@2157|Archaea,2XPVA@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
WLSH3_k127_7542449_15	387631.Asulf_00780	5.592e-23	102.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,246D0@183980|Archaeoglobi	183980|Archaeoglobi	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
WLSH3_k127_7542449_19	1184251.TCELL_0559	2.385e-15	83.0	COG0195@1|root,arCOG01761@2157|Archaea,2XQP0@28889|Crenarchaeota	28889|Crenarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7542449_3	397948.Cmaq_1576	3.644e-62	231.0	COG0585@1|root,arCOG04252@2157|Archaea,2XQXM@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
WLSH3_k127_7542449_10	70601.3257966	4.055e-36	140.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
WLSH3_k127_7542449_4	645991.Sgly_0856	6.724e-55	207.0	COG0644@1|root,COG0644@2|Bacteria,1TRTQ@1239|Firmicutes,24E1W@186801|Clostridia,261F2@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
WLSH3_k127_7542449_2	192952.MM_2535	2.204e-89	312.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
WLSH3_k127_7542449_16	591019.Shell_0022	1.675e-22	99.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
WLSH3_k127_7542449_21	304371.MCP_0724	1.025e-06	55.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
WLSH3_k127_7542449_7	589924.Ferp_0274	1.153e-44	169.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,246VN@183980|Archaeoglobi	183980|Archaeoglobi	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
WLSH3_k127_7542449_6	529709.PYCH_00940	1.226e-47	183.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,242SR@183968|Thermococci	183968|Thermococci	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
WLSH3_k127_7542449_12	272844.PAB0284	1.447e-32	134.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
WLSH3_k127_7542449_8	453591.Igni_0058	1.239e-40	161.0	COG1047@1|root,arCOG00980@2157|Archaea,2XQ07@28889|Crenarchaeota	28889|Crenarchaeota	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
WLSH3_k127_7542449_5	456442.Mboo_1384	1.033e-47	178.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
WLSH3_k127_7542449_0	386456.JQKN01000019_gene1316	1.742e-230	729.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
WLSH3_k127_7542449_9	368408.Tpen_0498	9.121e-37	161.0	COG1204@1|root,arCOG00553@2157|Archaea,2XPUH@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
WLSH3_k127_7542449_14	523845.AQXV01000040_gene1688	8.335e-30	125.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,23QZV@183939|Methanococci	183939|Methanococci	J	PFAM PUA domain containing protein	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
WLSH3_k127_7542449_17	1459636.NTE_02161	8.07e-16	79.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
WLSH3_k127_7542449_18	386456.JQKN01000002_gene2403	1.328e-15	78.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
WLSH3_k127_7542449_13	552811.Dehly_1590	7.289e-30	124.0	COG1720@1|root,COG1720@2|Bacteria,2G799@200795|Chloroflexi,34DAJ@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
WLSH3_k127_7542449_11	521011.Mpal_0671	1.837e-34	142.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
WLSH3_k127_7542449_22	717606.PaecuDRAFT_4465	1.758e-05	52.0	COG2730@1|root,COG3209@1|root,COG2730@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase,Cytochrom_C,Dockerin_1,F5_F8_type_C,Glyco_hydro_43,RicinB_lectin_2,Ricin_B_lectin
WLSH3_k127_7819668_17	1433287.X808_16170	2.524e-19	93.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1Y72Z@135625|Pasteurellales	135625|Pasteurellales	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
WLSH3_k127_7819668_28	765177.Desmu_1078	2.712e-05	53.0	COG1439@1|root,arCOG00721@2157|Archaea,2XQPH@28889|Crenarchaeota	28889|Crenarchaeota	V	nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
WLSH3_k127_7819668_12	304371.MCP_0732	4.158e-48	175.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
WLSH3_k127_7819668_13	1094980.Mpsy_2013	6.113e-39	162.0	COG1233@1|root,arCOG01524@2157|Archaea,2XSYN@28890|Euryarchaeota,2NA9X@224756|Methanomicrobia	224756|Methanomicrobia	Q	GDP dissociation inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
WLSH3_k127_7819668_9	246969.TAM4_1107	3.114e-53	194.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
WLSH3_k127_7819668_11	1229909.NSED_03065	2.215e-49	186.0	COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
WLSH3_k127_7819668_4	882.DVU_1778	1.548e-81	288.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7Z@28221|Deltaproteobacteria,2M8HE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
WLSH3_k127_7819668_3	1197130.BAFM01000010_gene1844	1.011e-91	317.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,23SVV@183963|Halobacteria	183963|Halobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
WLSH3_k127_7819668_8	368408.Tpen_0138	4.195e-57	210.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
WLSH3_k127_7819668_22	272557.APE_0537a	1.817e-09	64.0	COG4352@1|root,arCOG01013@2157|Archaea,2XR7C@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL13 family	rpl13e	-	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e
WLSH3_k127_7819668_25	268407.PWYN_04765	4.997e-07	61.0	COG0524@1|root,COG0524@2|Bacteria,1V123@1239|Firmicutes,4I8Y4@91061|Bacilli,26RQY@186822|Paenibacillaceae	91061|Bacilli	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
WLSH3_k127_7819668_31	13037.EHJ79074	0.0004929	49.0	KOG3330@1|root,KOG3330@2759|Eukaryota,38BCP@33154|Opisthokonta,3BC4V@33208|Metazoa,3D04K@33213|Bilateria,41YMR@6656|Arthropoda,3SKZQ@50557|Insecta,441JS@7088|Lepidoptera	33208|Metazoa	U	May play a role in vesicular transport from endoplasmic reticulum to Golgi	TRAPPC3	GO:0000139,GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005829,GO:0006403,GO:0006810,GO:0006888,GO:0006891,GO:0007275,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0012505,GO:0015031,GO:0015833,GO:0015931,GO:0016020,GO:0016192,GO:0018996,GO:0030008,GO:0031090,GO:0031984,GO:0032501,GO:0032502,GO:0032940,GO:0032991,GO:0033036,GO:0033227,GO:0035264,GO:0040002,GO:0040007,GO:0042303,GO:0042335,GO:0042338,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0048193,GO:0048589,GO:0048856,GO:0050657,GO:0050658,GO:0051179,GO:0051234,GO:0051236,GO:0051641,GO:0051649,GO:0071702,GO:0071705,GO:0098588,GO:0098791,GO:0099023	-	ko:K20302	-	-	-	-	ko00000,ko04131	-	-	-	TRAPP
WLSH3_k127_7819668_30	1121957.ATVL01000009_gene1343	0.0004828	44.0	COG0702@1|root,COG0702@2|Bacteria,4NFWH@976|Bacteroidetes,47KGG@768503|Cytophagia	976|Bacteroidetes	GM	SusD family	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	SusD-like_3,SusD_RagB
WLSH3_k127_7819668_24	1343739.PAP_09700	2.694e-08	64.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	183968|Thermococci	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_7819668_10	1121324.CLIT_11c00630	3.397e-51	191.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_7819668_29	1122997.AUDD01000010_gene786	4.873e-05	56.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4DQ29@85009|Propionibacteriales	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_7819668_1	644281.MFS40622_0309	7.234e-97	337.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,23Q0A@183939|Methanococci	183939|Methanococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
WLSH3_k127_7819668_15	1521187.JPIM01000023_gene768	2.139e-33	138.0	COG0558@1|root,COG0558@2|Bacteria,2GAQW@200795|Chloroflexi,3773G@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
WLSH3_k127_7819668_19	246969.TAM4_1366	9.831e-16	88.0	COG0524@1|root,arCOG00014@2157|Archaea,2Y67H@28890|Euryarchaeota,2431X@183968|Thermococci	183968|Thermococci	G	Belongs to the carbohydrate kinase PfkB family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0071704	2.7.1.213	ko:K21057	ko00240,map00240	-	R00513,R00964,R01666	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
WLSH3_k127_7819668_16	529709.PYCH_11660	1.089e-21	100.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y6ET@28890|Euryarchaeota,244B9@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_7819668_23	69014.TK0554	1.906e-08	63.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,242WH@183968|Thermococci	183968|Thermococci	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
WLSH3_k127_7819668_5	370438.PTH_2033	8.005e-64	232.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,24AAC@186801|Clostridia,260MS@186807|Peptococcaceae	186801|Clostridia	BQ	histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
WLSH3_k127_7819668_18	1293048.CBMB010000010_gene3393	8.958e-17	94.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23SC2@183963|Halobacteria	183963|Halobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
WLSH3_k127_7819668_21	1111479.AXAR01000025_gene2869	1.273e-10	68.0	COG1051@1|root,COG1051@2|Bacteria,1UWQJ@1239|Firmicutes,4IFRF@91061|Bacilli,27AGX@186823|Alicyclobacillaceae	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
WLSH3_k127_7819668_6	999630.TUZN_0563	1.168e-60	221.0	COG2248@1|root,arCOG00969@2157|Archaea,2XQEH@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
WLSH3_k127_7819668_7	379066.GAU_2113	1.46e-59	215.0	COG4181@1|root,COG4181@2|Bacteria,1ZUJS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_7819668_20	399550.Smar_0879	5.392e-15	77.0	COG3609@1|root,arCOG01009@2157|Archaea,2XR62@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
WLSH3_k127_7819668_14	5932.XP_004034853.1	1.085e-34	139.0	COG1100@1|root,KOG0087@2759|Eukaryota,3ZBS7@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07904,ko:K07905	ko04144,ko04152,ko04961,ko04962,ko04972,map04144,map04152,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_7819668_2	1134413.ANNK01000052_gene1159	1.303e-94	323.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,4H9SM@91061|Bacilli,1ZD06@1386|Bacillus	91061|Bacilli	G	COG1363 Cellulase M and related proteins	ysdC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
WLSH3_k127_7819668_0	374847.Kcr_1066	1.679e-121	399.0	COG1260@1|root,arCOG04213@2157|Archaea	2157|Archaea	I	myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
WLSH3_k127_7819668_26	933801.Ahos_0836	6.366e-07	60.0	COG1948@1|root,arCOG04206@2157|Archaea,2XQJU@28889|Crenarchaeota	28889|Crenarchaeota	L	ERCC4 domain protein	-	-	-	ko:K10848	ko03420,ko03460,map03420,map03460	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	ERCC4,HHH_5
WLSH3_k127_7819668_27	1343739.PAP_05965	6.097e-06	56.0	arCOG02103@1|root,arCOG02103@2157|Archaea,2Y1N3@28890|Euryarchaeota,245FV@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
WLSH3_k127_7939511_1	1121382.JQKG01000042_gene929	1.367e-05	58.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1WMEN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	MV	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WLSH3_k127_7939511_0	1408254.T458_09655	1.659e-48	186.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,4HC59@91061|Bacilli,26SC2@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_7948414_27	1235793.C809_03930	2.285e-07	57.0	28Q1F@1|root,2ZCJT@2|Bacteria,1VI7R@1239|Firmicutes,24D4W@186801|Clostridia,27M4D@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7948414_9	545695.TREAZ_2799	1.55e-71	250.0	COG1533@1|root,COG1533@2|Bacteria,2J5YS@203691|Spirochaetes	203691|Spirochaetes	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_7948414_14	926569.ANT_22340	1.191e-49	195.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
WLSH3_k127_7948414_30	494416.AYXN01000039_gene2269	0.0008021	51.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,3NN6W@468|Moraxellaceae	1236|Gammaproteobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_7948414_31	756067.MicvaDRAFT_4070	0.0009956	51.0	COG0693@1|root,COG0693@2|Bacteria,1G2VP@1117|Cyanobacteria,1H8JH@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM DJ-1 PfpI family	-	-	3.5.1.124	ko:K03152,ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI,DUF2383
WLSH3_k127_7948414_18	529709.PYCH_03760	5.686e-42	171.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,242W4@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_7948414_8	368408.Tpen_0043	2.768e-72	261.0	COG1530@1|root,arCOG00321@2157|Archaea,2XQ2D@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_7948414_20	926550.CLDAP_35280	1.588e-34	142.0	COG0454@1|root,COG0456@2|Bacteria,2G91C@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_7948414_19	234267.Acid_5754	4.158e-39	150.0	COG3324@1|root,COG3324@2|Bacteria,3Y8A9@57723|Acidobacteria	57723|Acidobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_7948414_12	1401078.HMPREF2140_00800	4.019e-56	221.0	COG0827@1|root,COG0827@2|Bacteria,4P1K4@976|Bacteroidetes,2FX1M@200643|Bacteroidia	976|Bacteroidetes	L	Eco57I restriction-modification methylase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7948414_7	470145.BACCOP_00223	1.24e-85	298.0	COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,2FNPZ@200643|Bacteroidia,4AN9J@815|Bacteroidaceae	976|Bacteroidetes	H	C-5 cytosine-specific DNA methylase	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
WLSH3_k127_7948414_26	7897.ENSLACP00000004392	3.717e-08	66.0	COG1100@1|root,KOG0070@2759|Eukaryota,38MMH@33154|Opisthokonta,3BGDN@33208|Metazoa,3CXVP@33213|Bilateria,4865M@7711|Chordata,48Z18@7742|Vertebrata	33208|Metazoa	U	Belongs to the small GTPase superfamily. Arf family	ARL4D	GO:0002790,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032940,GO:0033036,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K07945	-	-	-	-	ko00000,ko04031	-	-	-	Arf
WLSH3_k127_7948414_17	384616.Pisl_0558	4.368e-45	186.0	COG1236@1|root,arCOG00541@2157|Archaea,2XPVA@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
WLSH3_k127_7948414_10	1459636.NTE_01921	1.144e-60	222.0	COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota	651137|Thaumarchaeota	HK	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
WLSH3_k127_7948414_6	1220534.B655_1873	5.149e-88	301.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,23NN6@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
WLSH3_k127_7948414_29	228405.HNE_2245	4.811e-05	53.0	COG0546@1|root,COG0546@2|Bacteria,1R6SG@1224|Proteobacteria,2TUUY@28211|Alphaproteobacteria,43ZSX@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
WLSH3_k127_7948414_2	443254.Marpi_1626	9.863e-116	385.0	COG0156@1|root,COG0156@2|Bacteria,2GCC8@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_7948414_5	456442.Mboo_0455	5.348e-103	342.0	COG1741@1|root,arCOG02935@2157|Archaea,2XU8Z@28890|Euryarchaeota,2N95U@224756|Methanomicrobia	224756|Methanomicrobia	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
WLSH3_k127_7948414_22	688269.Theth_0659	4.723e-22	104.0	COG1670@1|root,COG1670@2|Bacteria,2GCZ2@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
WLSH3_k127_7948414_24	694431.DESACE_06605	3.503e-09	63.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
WLSH3_k127_7948414_25	65093.PCC7418_1391	2.787e-08	66.0	COG1672@1|root,COG1672@2|Bacteria,1GQEK@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7948414_23	1184251.TCELL_0041	2.005e-13	78.0	COG0681@1|root,arCOG01739@2157|Archaea,2XQV6@28889|Crenarchaeota	28889|Crenarchaeota	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
WLSH3_k127_7948414_4	269797.Mbar_A2729	6.708e-106	365.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
WLSH3_k127_7948414_1	861299.J421_2136	1.464e-139	460.0	COG0405@1|root,COG0405@2|Bacteria,1ZUCB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
WLSH3_k127_7948414_0	1155718.KB891907_gene1059	6.158e-151	491.0	COG1027@1|root,COG1027@2|Bacteria,2I2HG@201174|Actinobacteria	201174|Actinobacteria	E	Aspartate ammonia-lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
WLSH3_k127_7948414_3	1167006.UWK_00583	1.289e-106	366.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
WLSH3_k127_7948414_21	1267005.KB911257_gene1051	9.977e-23	108.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria,3N86N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7948414_13	351160.RCIX86	3.384e-52	201.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_7948414_16	304371.MCP_2060	1.602e-48	188.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_7948414_11	706587.Desti_3183	3.105e-59	233.0	COG2202@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,42QA2@68525|delta/epsilon subdivisions,2X7QC@28221|Deltaproteobacteria,2MQRX@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS_9
WLSH3_k127_7948414_15	485913.Krac_11873	1.608e-49	181.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yxbD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Acetyltransf_1
WLSH3_k127_7948414_28	1357275.AVEL02000011_gene3732	1.082e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1RA6D@1224|Proteobacteria,1SSC3@1236|Gammaproteobacteria,1Z7U3@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_806096_42	1184251.TCELL_0130	4.948e-22	98.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
WLSH3_k127_806096_45	304371.MCP_1536	3.519e-14	74.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
WLSH3_k127_806096_19	1343739.PAP_03440	1.81e-57	209.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,243FV@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
WLSH3_k127_806096_47	1056495.Calag_0373	1.341e-12	68.0	COG2260@1|root,arCOG00906@2157|Archaea,2XR3J@28889|Crenarchaeota	28889|Crenarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
WLSH3_k127_806096_14	32264.tetur13g03920.1	5.199e-80	298.0	COG1287@1|root,KOG2292@2759|Eukaryota,38D8E@33154|Opisthokonta,3BGVU@33208|Metazoa,3CSAS@33213|Bilateria,41VIW@6656|Arthropoda	33208|Metazoa	O	Oligosaccharyl transferase activity. It is involved in the biological process described with protein glycosylation	STT3A	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043686,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
WLSH3_k127_806096_30	575564.HMPREF0014_01299	1.041e-37	145.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,3NNJE@468|Moraxellaceae	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
WLSH3_k127_806096_11	292459.STH1922	1.186e-89	308.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
WLSH3_k127_806096_17	1184251.TCELL_0939	1.12e-61	222.0	COG0294@1|root,arCOG02817@2157|Archaea,2XSR1@28889|Crenarchaeota	28889|Crenarchaeota	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
WLSH3_k127_806096_24	391623.TERMP_01266	1.507e-50	189.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,24344@183968|Thermococci	183968|Thermococci	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
WLSH3_k127_806096_6	391623.TERMP_00652	5.394e-160	529.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
WLSH3_k127_806096_7	1042877.GQS_10350	2.785e-123	420.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
WLSH3_k127_806096_51	751944.HALDL1_13145	2.78e-06	58.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,23SVJ@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_806096_40	386456.JQKN01000001_gene1784	7.029e-25	113.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23NZU@183925|Methanobacteria	183925|Methanobacteria	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
WLSH3_k127_806096_28	69014.TK2119	6.32e-40	154.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,243AW@183968|Thermococci	183968|Thermococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
WLSH3_k127_806096_20	868131.MSWAN_0409	3.687e-57	209.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,23NXA@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
WLSH3_k127_806096_2	195522.BD01_1826	1.594e-303	968.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
WLSH3_k127_806096_22	647113.Metok_0123	1.694e-52	207.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
WLSH3_k127_806096_10	1236689.MMALV_07230	7.472e-101	344.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota	2157|Archaea	E	Cysteine desulfurase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
WLSH3_k127_806096_48	397948.Cmaq_0929	2.576e-12	69.0	COG4888@1|root,arCOG04136@2157|Archaea	2157|Archaea	S	PFAM Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
WLSH3_k127_806096_53	673860.AciM339_0016	0.000108	48.0	arCOG05717@1|root,arCOG05717@2157|Archaea,2Y77I@28890|Euryarchaeota,3F3IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_806096_4	351160.RCIX231	1.504e-187	619.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
WLSH3_k127_806096_32	1151117.AJLF01000001_gene1279	1.364e-35	146.0	COG0218@1|root,arCOG00355@2157|Archaea,2XTV8@28890|Euryarchaeota,243FK@183968|Thermococci	183968|Thermococci	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
WLSH3_k127_806096_52	1365176.N186_04495	2.748e-05	51.0	COG5431@1|root,arCOG01120@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
WLSH3_k127_806096_38	1041930.Mtc_1658	7.962e-29	127.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
WLSH3_k127_806096_12	35128.Thaps2376	4.886e-87	297.0	COG1577@1|root,KOG1511@2759|Eukaryota,2XDVQ@2836|Bacillariophyta	2836|Bacillariophyta	I	GHMP kinases C terminal	-	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
WLSH3_k127_806096_13	523850.TON_0392	1.515e-86	302.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
WLSH3_k127_806096_9	868131.MSWAN_2414	7.805e-110	367.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23NR8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
WLSH3_k127_806096_31	69014.TK1248	1.147e-36	142.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2445F@183968|Thermococci	183968|Thermococci	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
WLSH3_k127_806096_16	415426.Hbut_0535	1.511e-69	241.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
WLSH3_k127_806096_41	1183377.Py04_1524	4.941e-22	98.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
WLSH3_k127_806096_26	420247.Msm_1431	4.677e-42	158.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
WLSH3_k127_806096_35	391623.TERMP_00133	4.37e-31	127.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
WLSH3_k127_806096_36	246969.TAM4_22	1.986e-30	124.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2444E@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
WLSH3_k127_806096_15	1041930.Mtc_1534	2.134e-70	246.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
WLSH3_k127_806096_50	85929.N1QKX6	2.898e-09	65.0	COG1100@1|root,KOG0071@2759|Eukaryota,38I0U@33154|Opisthokonta,3NYP1@4751|Fungi,3QNJ5@4890|Ascomycota,201AM@147541|Dothideomycetes,3MH9S@451867|Dothideomycetidae	4751|Fungi	U	Belongs to the small GTPase superfamily. Arf family	-	GO:0000139,GO:0000166,GO:0000278,GO:0000281,GO:0000282,GO:0000910,GO:0000935,GO:0001558,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005829,GO:0005933,GO:0005934,GO:0005935,GO:0005938,GO:0006810,GO:0006886,GO:0006888,GO:0006897,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007154,GO:0007163,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008360,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010511,GO:0010513,GO:0010562,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019216,GO:0019220,GO:0019222,GO:0022402,GO:0022603,GO:0022604,GO:0022607,GO:0023052,GO:0030010,GO:0030029,GO:0030036,GO:0030234,GO:0030307,GO:0030427,GO:0030428,GO:0030447,GO:0031090,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031984,GO:0032153,GO:0032155,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0034613,GO:0035556,GO:0035639,GO:0036094,GO:0036267,GO:0040007,GO:0040008,GO:0042886,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044182,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044448,GO:0044464,GO:0045184,GO:0045834,GO:0045927,GO:0045937,GO:0046889,GO:0046890,GO:0046907,GO:0048193,GO:0048518,GO:0048522,GO:0048638,GO:0048639,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051017,GO:0051094,GO:0051128,GO:0051130,GO:0051174,GO:0051179,GO:0051234,GO:0051285,GO:0051286,GO:0051301,GO:0051510,GO:0051512,GO:0051516,GO:0051518,GO:0051519,GO:0051523,GO:0051641,GO:0051649,GO:0051666,GO:0051716,GO:0061171,GO:0061389,GO:0061572,GO:0061640,GO:0065007,GO:0065008,GO:0065009,GO:0070727,GO:0070783,GO:0071071,GO:0071073,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0097435,GO:0098588,GO:0098657,GO:0098772,GO:0098791,GO:0099568,GO:0099738,GO:1901265,GO:1901363,GO:1903047,GO:1903725,GO:1903727	-	ko:K07941	ko04014,ko04072,ko04144,ko04666,map04014,map04072,map04144,map04666	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Arf
WLSH3_k127_806096_27	387631.Asulf_02016	3.667e-40	161.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,24609@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
WLSH3_k127_806096_29	69014.TK1311	9.597e-39	147.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
WLSH3_k127_806096_39	453591.Igni_0723	5.507e-26	109.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
WLSH3_k127_806096_46	330779.Saci_0697	6.977e-14	73.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
WLSH3_k127_806096_33	551115.Aazo_1845	1.366e-33	138.0	COG0105@1|root,COG0105@2|Bacteria,1G4ZN@1117|Cyanobacteria,1HN1K@1161|Nostocales	1117|Cyanobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
WLSH3_k127_806096_3	453591.Igni_0001	1.779e-194	623.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
WLSH3_k127_806096_23	1121405.dsmv_0900	7.108e-51	187.0	COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
WLSH3_k127_806096_44	1162668.LFE_0393	2.054e-17	94.0	COG4447@1|root,COG4447@2|Bacteria,3J16A@40117|Nitrospirae	40117|Nitrospirae	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
WLSH3_k127_806096_5	368408.Tpen_0647	3.501e-182	578.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
WLSH3_k127_806096_25	1540257.JQMW01000009_gene3474	7.474e-46	171.0	COG0454@1|root,COG0456@2|Bacteria,1VCRG@1239|Firmicutes,24HS4@186801|Clostridia,36JB9@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_806096_34	386456.JQKN01000010_gene620	7.07e-32	131.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
WLSH3_k127_806096_21	1365176.N186_02245	5.607e-57	205.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
WLSH3_k127_806096_18	368408.Tpen_0281	8.775e-58	205.0	COG0048@1|root,arCOG04255@2157|Archaea,2XQ79@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WLSH3_k127_806096_37	410359.Pcal_2095	3.089e-30	124.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
WLSH3_k127_806096_43	267377.MMP1365	5.736e-19	89.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,23R1G@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
WLSH3_k127_806096_8	1163730.FFONT_0600	8.301e-113	379.0	COG0086@1|root,arCOG04256@2157|Archaea,2XPSD@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
WLSH3_k127_806096_1	644281.MFS40622_1659	0.0	1060.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,23QG8@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Intein_splicing,RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
WLSH3_k127_806096_0	933801.Ahos_0748	0.0	1313.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WLSH3_k127_8234421_18	1396418.BATQ01000091_gene5784	6.219e-05	47.0	2EXIW@1|root,33QV1@2|Bacteria,46U1U@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8234421_16	263820.PTO0382	8.333e-10	64.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_8234421_5	543526.Htur_1150	3.946e-89	307.0	COG1960@1|root,arCOG01709@2157|Archaea,2XTZR@28890|Euryarchaeota,23SJ8@183963|Halobacteria	183963|Halobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_8234421_17	1292035.H476_2231	4.49e-08	66.0	2BW99@1|root,2Z7PD@2|Bacteria,1TQFA@1239|Firmicutes,249NB@186801|Clostridia,25R27@186804|Peptostreptococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8234421_8	1121468.AUBR01000010_gene2458	2.18e-42	160.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,42G3R@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
WLSH3_k127_8234421_1	1220534.B655_1784	2.355e-123	408.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23PD9@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
WLSH3_k127_8234421_2	1121946.AUAX01000021_gene8088	8.493e-100	338.0	COG0473@1|root,COG0473@2|Bacteria,2I8V7@201174|Actinobacteria	201174|Actinobacteria	CE	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
WLSH3_k127_8234421_6	1462527.CCDM010000006_gene4704	3.509e-74	259.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,4HCBR@91061|Bacilli,23MKV@182709|Oceanobacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
WLSH3_k127_8234421_9	444158.MmarC6_1787	7.794e-26	115.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,23R7V@183939|Methanococci	183939|Methanococci	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
WLSH3_k127_8234421_7	635013.TherJR_1575	9.306e-54	199.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,26325@186807|Peptococcaceae	186801|Clostridia	E	histidinol phosphate phosphatase	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
WLSH3_k127_8234421_12	1457250.BBMO01000001_gene1131	7.52e-18	96.0	COG0477@1|root,arCOG00134@2157|Archaea,2Y8EP@28890|Euryarchaeota,2419U@183963|Halobacteria	183963|Halobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_8234421_10	1157637.KB892091_gene5688	7.381e-25	121.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
WLSH3_k127_8234421_0	373903.Hore_21960	1.843e-139	479.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WB3A@53433|Halanaerobiales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
WLSH3_k127_8234421_3	1121423.JONT01000026_gene890	1.989e-99	332.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,260CY@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
WLSH3_k127_8234421_13	1200557.JHWV01000001_gene547	9.756e-18	84.0	2DNM3@1|root,32Y2K@2|Bacteria,1UKQ2@1239|Firmicutes,4H9CB@909932|Negativicutes	909932|Negativicutes	S	cluster protein-associated redox disulfide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
WLSH3_k127_8234421_14	1048339.KB913029_gene3229	1.426e-10	68.0	2EHBA@1|root,33B35@2|Bacteria,2I3RH@201174|Actinobacteria	201174|Actinobacteria	S	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_8234421_4	273075.Ta1498	3.195e-98	337.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,241WU@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
WLSH3_k127_8234421_15	272844.PAB1938	5.062e-10	66.0	COG1522@1|root,arCOG01580@2157|Archaea,2XXGY@28890|Euryarchaeota,243ZR@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_8234421_11	926550.CLDAP_23540	3.878e-18	89.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
WLSH3_k127_8277309_18	60711.ENSCSAP00000008267	8.049e-12	69.0	KOG4115@1|root,KOG4115@2759|Eukaryota,3A3F9@33154|Opisthokonta,3BRCD@33208|Metazoa,3D83H@33213|Bilateria,48F9Q@7711|Chordata,49C31@7742|Vertebrata,3JHD6@40674|Mammalia,35QIA@314146|Euarchontoglires,4MJSI@9443|Primates,36B7Q@314294|Cercopithecoidea	33208|Metazoa	DN	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules	DYNLRB1	GO:0000902,GO:0000904,GO:0003674,GO:0003774,GO:0003777,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005856,GO:0005858,GO:0005868,GO:0005874,GO:0005875,GO:0005876,GO:0005929,GO:0005930,GO:0005938,GO:0006810,GO:0006928,GO:0006996,GO:0007017,GO:0007018,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007610,GO:0007632,GO:0008088,GO:0008090,GO:0008150,GO:0009314,GO:0009416,GO:0009628,GO:0009653,GO:0009987,GO:0010970,GO:0015630,GO:0016043,GO:0016319,GO:0016358,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022008,GO:0022607,GO:0030030,GO:0030031,GO:0030154,GO:0030182,GO:0030286,GO:0030705,GO:0031175,GO:0031503,GO:0032501,GO:0032502,GO:0032838,GO:0032989,GO:0032990,GO:0032991,GO:0035735,GO:0036157,GO:0042073,GO:0042623,GO:0042802,GO:0042995,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044447,GO:0044463,GO:0044464,GO:0044782,GO:0045505,GO:0046907,GO:0048468,GO:0048471,GO:0048513,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060271,GO:0060322,GO:0070925,GO:0071840,GO:0071944,GO:0097014,GO:0097542,GO:0098930,GO:0099080,GO:0099081,GO:0099111,GO:0099512,GO:0099513,GO:0099568,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0120039,GO:1902494	-	ko:K10419	-	-	-	-	ko00000,ko04131,ko04812	-	-	-	Robl_LC7
WLSH3_k127_8277309_12	7668.SPU_005782-tr	4.065e-27	127.0	COG1100@1|root,KOG0395@2759|Eukaryota,39D71@33154|Opisthokonta,3BMYE@33208|Metazoa,3D5GM@33213|Bilateria	33208|Metazoa	S	Sec23/Sec24 zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	Ras,zf-Sec23_Sec24
WLSH3_k127_8277309_0	1343739.PAP_06100	6.672e-173	586.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
WLSH3_k127_8277309_15	195522.BD01_0919	1.07e-18	94.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2434N@183968|Thermococci	183968|Thermococci	L	Segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
WLSH3_k127_8277309_10	192952.MM_1029	4.403e-32	132.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
WLSH3_k127_8277309_4	1220534.B655_2351	1.911e-99	334.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,23NWV@183925|Methanobacteria	183925|Methanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
WLSH3_k127_8277309_11	693661.Arcve_2023	8.694e-30	122.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,2473C@183980|Archaeoglobi	183980|Archaeoglobi	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
WLSH3_k127_8277309_14	224719.Abm4_0603	1.247e-22	102.0	COG0375@1|root,arCOG04426@2157|Archaea,2XZI2@28890|Euryarchaeota,23P60@183925|Methanobacteria	183925|Methanobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
WLSH3_k127_8277309_19	237368.SCABRO_03881	2.047e-06	57.0	COG1413@1|root,COG1413@2|Bacteria,2J011@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
WLSH3_k127_8277309_3	386456.JQKN01000001_gene1892	1.213e-115	391.0	COG0479@1|root,arCOG00963@2157|Archaea,2Y85K@28890|Euryarchaeota,23PZE@183925|Methanobacteria	183925|Methanobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
WLSH3_k127_8277309_1	1220534.B655_1070	1.105e-153	503.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	sdhA	-	1.3.4.1	ko:K18209	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_8277309_8	673860.AciM339_1147	7.87e-67	233.0	COG1838@1|root,arCOG04406@2157|Archaea,2XXBQ@28890|Euryarchaeota,3F2QU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
WLSH3_k127_8277309_5	439481.Aboo_0990	8.367e-92	311.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,3F2K1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
WLSH3_k127_8277309_20	269797.Mbar_A1491	0.0004221	50.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,2N9XX@224756|Methanomicrobia	224756|Methanomicrobia	N	Peptidase A24A, prepilin type IV	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
WLSH3_k127_8277309_2	272844.PAB1903	9.184e-139	467.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
WLSH3_k127_8277309_16	1162668.LFE_0967	4.524e-16	85.0	COG2905@1|root,COG2905@2|Bacteria,3J0UW@40117|Nitrospirae	40117|Nitrospirae	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
WLSH3_k127_8277309_13	1198449.ACAM_1368	3.378e-26	118.0	COG0517@1|root,arCOG00600@2157|Archaea,2XQKZ@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
WLSH3_k127_8277309_6	314230.DSM3645_12666	3.71e-70	254.0	COG0044@1|root,COG0044@2|Bacteria,2IWWW@203682|Planctomycetes	203682|Planctomycetes	F	dihydroorotase	-	-	3.5.2.2,3.5.2.3,3.5.2.5	ko:K01464,ko:K01465,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00051,M00546	R01993,R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
WLSH3_k127_8277309_9	1343739.PAP_06535	1.736e-64	226.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
WLSH3_k127_8277309_7	224719.Abm4_1366	9.488e-68	240.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
WLSH3_k127_8277309_17	1227360.C176_11389	8.522e-13	81.0	COG0425@1|root,COG0607@1|root,COG0425@2|Bacteria,COG0607@2|Bacteria,1V1GU@1239|Firmicutes,4HFR8@91061|Bacilli,26F3H@186818|Planococcaceae	91061|Bacilli	OP	Belongs to the sulfur carrier protein TusA family	yrkF	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,TusA
WLSH3_k127_8295682_8	309799.DICTH_0189	1.333e-21	102.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
WLSH3_k127_8295682_9	118168.MC7420_4969	1.754e-21	98.0	COG1733@1|root,COG1733@2|Bacteria,1G6J8@1117|Cyanobacteria,1HBM3@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
WLSH3_k127_8295682_11	374847.Kcr_0937	2.352e-15	85.0	COG3371@1|root,arCOG02008@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
WLSH3_k127_8295682_4	1121422.AUMW01000012_gene2931	3.204e-66	236.0	COG1788@1|root,COG1788@2|Bacteria,1UYH2@1239|Firmicutes,24CPB@186801|Clostridia	186801|Clostridia	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
WLSH3_k127_8295682_3	439235.Dalk_2102	5.112e-67	237.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
WLSH3_k127_8295682_10	1298598.JCM21714_48	5.478e-16	87.0	COG1011@1|root,COG1011@2|Bacteria,1V3WC@1239|Firmicutes,4HMA8@91061|Bacilli	91061|Bacilli	S	hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
WLSH3_k127_8295682_13	1009370.ALO_10419	0.0003157	46.0	COG1750@1|root,COG1750@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Lon_C,SdrD_B
WLSH3_k127_8295682_12	269797.Mbar_A2531	1.183e-07	63.0	COG2512@1|root,arCOG00377@2157|Archaea,2XY2E@28890|Euryarchaeota	28890|Euryarchaeota	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_8295682_5	555079.Toce_1199	3.849e-58	204.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42G8Z@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
WLSH3_k127_8295682_1	555088.DealDRAFT_3073	8.7e-98	329.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia,42KHQ@68298|Syntrophomonadaceae	186801|Clostridia	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
WLSH3_k127_8295682_0	1304284.L21TH_0800	4.784e-246	770.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,36H9W@31979|Clostridiaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
WLSH3_k127_8295682_7	1232410.KI421417_gene2738	2.003e-49	181.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,43V0S@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
WLSH3_k127_8295682_2	935836.JAEL01000022_gene1658	1.559e-91	312.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HAM3@91061|Bacilli,1ZD31@1386|Bacillus	91061|Bacilli	E	Threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
WLSH3_k127_8295682_6	1041930.Mtc_1580	1.314e-52	204.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_8316101_5	1094980.Mpsy_3012	1.726e-79	276.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2N98S@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
WLSH3_k127_8316101_17	697303.Thewi_2684	1.708e-07	64.0	COG0738@1|root,COG0738@2|Bacteria,1UJ6C@1239|Firmicutes,2494T@186801|Clostridia	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	ko:K18214	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.6	-	-	MFS_1
WLSH3_k127_8316101_20	436308.Nmar_1429	0.0002794	47.0	COG1617@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG02197@2157|Archaea,41SSW@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Kinase binding protein CGI-121	-	-	-	-	-	-	-	-	-	-	-	-	CGI-121,ThiS
WLSH3_k127_8316101_8	1220534.B655_0443	4.487e-44	166.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
WLSH3_k127_8316101_4	1343739.PAP_05655	1.439e-87	297.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2436C@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit beta	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_8316101_18	1128398.Curi_c14500	4.875e-07	61.0	COG1266@1|root,COG1266@2|Bacteria,1V1I8@1239|Firmicutes,24EXX@186801|Clostridia	186801|Clostridia	S	CAAX amino terminal protease family protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_8316101_13	572478.Vdis_1863	6.461e-16	83.0	COG1958@1|root,arCOG00999@2157|Archaea,2XR1U@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
WLSH3_k127_8316101_2	523845.AQXV01000054_gene1543	9.232e-123	406.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
WLSH3_k127_8316101_14	272844.PAB1522.1n	2.919e-10	64.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZXP@28890|Euryarchaeota,244NJ@183968|Thermococci	183968|Thermococci	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
WLSH3_k127_8316101_7	1202768.JROF01000007_gene2701	9.04e-73	252.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,23RZZ@183963|Halobacteria	183963|Halobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2p	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WLSH3_k127_8316101_11	529709.PYCH_01390	2.162e-23	101.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
WLSH3_k127_8316101_6	1220534.B655_1959	2.647e-78	270.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
WLSH3_k127_8316101_3	572546.Arcpr_1361	8.004e-99	333.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
WLSH3_k127_8316101_0	349161.Dred_2965	0.0	1094.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
WLSH3_k127_8316101_10	304371.MCP_2219	2.823e-36	148.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
WLSH3_k127_8316101_12	1006006.Mcup_1937	3.312e-23	104.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
WLSH3_k127_8316101_1	439481.Aboo_1085	1.194e-157	513.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,3F2HC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Radical_SAM C-terminal domain	elp3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
WLSH3_k127_8316101_15	273057.SSO6817	2.803e-09	59.0	COG4919@1|root,arCOG04293@2157|Archaea,2XR5C@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
WLSH3_k127_8316101_19	368407.Memar_0383	0.000107	49.0	COG1403@1|root,arCOG03898@2157|Archaea	2157|Archaea	V	COG1403 Restriction endonuclease	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HNH
WLSH3_k127_8316101_9	459349.CLOAM1099	4.994e-43	159.0	COG2987@1|root,COG2987@2|Bacteria,2NP09@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_0688	Urocanase,Urocanase_C,Urocanase_N
WLSH3_k127_8316101_16	65489.OBART03G28910.1	6.874e-08	60.0	COG4886@1|root,2QPYS@2759|Eukaryota,37Q18@33090|Viridiplantae,3GCT9@35493|Streptophyta,3KYW0@4447|Liliopsida,3IKM8@38820|Poales	35493|Streptophyta	T	Leucine rich repeat	-	-	2.7.11.1	ko:K04730	ko04010,ko04064,ko04620,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05169,map04010,map04064,map04620,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05169	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	LRRNT_2,LRR_1,LRR_4,LRR_8,Pkinase,Pkinase_Tyr
WLSH3_k127_8316312_1	552811.Dehly_0707	1.631e-79	274.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2G6SR@200795|Chloroflexi,34CV6@301297|Dehalococcoidia	200795|Chloroflexi	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00266,ko:K03388	ko00250,ko00680,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00250,map00680,map00910,map01100,map01110,map01120,map01130,map01200,map01230	M00356,M00357,M00563,M00567	R00093,R00114,R00248,R04540,R11928,R11931,R11943,R11944	RC00006,RC00010,RC00011,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Pyr_redox_2
WLSH3_k127_8316312_0	1121396.KB893094_gene4440	4.625e-274	861.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_8365017_4	1453505.JASY01000002_gene3111	6.743e-15	80.0	COG2318@1|root,COG2318@2|Bacteria,4NW0H@976|Bacteroidetes,1I9WS@117743|Flavobacteriia,2NYW6@237|Flavobacterium	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
WLSH3_k127_8365017_6	1121346.KB899843_gene1043	9.331e-08	63.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,4H9R4@91061|Bacilli,26QAT@186822|Paenibacillaceae	91061|Bacilli	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
WLSH3_k127_8365017_5	1210908.HSB1_09030	4.237e-12	77.0	COG1413@1|root,arCOG02966@2157|Archaea,2XSWS@28890|Euryarchaeota,23SIB@183963|Halobacteria	183963|Halobacteria	C	COG1413 FOG HEAT repeat	cpcE2	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS
WLSH3_k127_8365017_1	63737.Npun_R0619	2.08e-62	223.0	COG1028@1|root,COG1028@2|Bacteria,1G7G6@1117|Cyanobacteria,1HQIB@1161|Nostocales	1117|Cyanobacteria	C	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
WLSH3_k127_8365017_2	1541959.KQ51_00260	7.462e-47	181.0	2E6H4@1|root,3314B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8365017_0	264732.Moth_1287	1.899e-128	422.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,42FP2@68295|Thermoanaerobacterales	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
WLSH3_k127_8365017_3	304371.MCP_2203	1.688e-24	109.0	COG1266@1|root,arCOG02766@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_8380457_1	1499967.BAYZ01000152_gene1402	4.908e-108	367.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
WLSH3_k127_8380457_6	649349.Lbys_2575	6.003e-70	250.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
WLSH3_k127_8380457_16	114615.BRADO6711	0.0002546	52.0	COG0454@1|root,COG0456@2|Bacteria,1R4SN@1224|Proteobacteria,2U0VQ@28211|Alphaproteobacteria,3JW84@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_8380457_8	309801.trd_0142	8.041e-66	238.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
WLSH3_k127_8380457_7	765420.OSCT_0964	2.065e-67	240.0	COG1131@1|root,COG1131@2|Bacteria,2G6KA@200795|Chloroflexi	200795|Chloroflexi	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_8380457_13	582899.Hden_0804	5.064e-18	94.0	COG4689@1|root,COG4689@2|Bacteria,1N4IP@1224|Proteobacteria,2TTZX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Catalyzes the conversion of acetoacetate to acetone and carbon dioxide	adc	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
WLSH3_k127_8380457_11	1410668.JNKC01000006_gene678	1.856e-28	126.0	COG0671@1|root,COG0671@2|Bacteria,1V01Y@1239|Firmicutes,24DFI@186801|Clostridia,36VSV@31979|Clostridiaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
WLSH3_k127_8380457_2	1191523.MROS_2356	5.416e-102	351.0	COG2195@1|root,COG2195@2|Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_8380457_0	926569.ANT_14670	3.042e-142	472.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_8380457_3	926569.ANT_14660	4.165e-101	342.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
WLSH3_k127_8380457_5	1121472.AQWN01000009_gene439	2.206e-92	316.0	COG2070@1|root,COG2070@2|Bacteria,1VTQJ@1239|Firmicutes,24ZN0@186801|Clostridia,26495@186807|Peptococcaceae	186801|Clostridia	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
WLSH3_k127_8380457_9	269799.Gmet_2663	8.503e-37	156.0	COG0457@1|root,COG4627@1|root,COG0457@2|Bacteria,COG4627@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
WLSH3_k127_8380457_4	269799.Gmet_2664	2.555e-93	317.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
WLSH3_k127_8380457_10	273116.14324612	1.509e-35	140.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota	28890|Euryarchaeota	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_8380457_12	1150599.MPHLEI_26146	1.589e-18	94.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,235IE@1762|Mycobacteriaceae	201174|Actinobacteria	E	PHP domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
WLSH3_k127_8380457_15	33876.JNXY01000035_gene769	1.667e-08	65.0	COG1522@1|root,COG1522@2|Bacteria,2IFSQ@201174|Actinobacteria,4DD8R@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_8380457_14	523850.TON_1663	2.498e-12	75.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_8450413_0	1444711.CCJF01000005_gene546	1.882e-76	273.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
WLSH3_k127_8450413_1	1444711.CCJF01000005_gene546	3.699e-64	241.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
WLSH3_k127_8587315_22	526227.Mesil_1127	2.846e-34	142.0	2CAQ4@1|root,33YR3@2|Bacteria,1WMW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8587315_12	632245.CLP_0748	1.313e-68	251.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,36E7S@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_8587315_30	309801.trd_0760	2.807e-10	72.0	COG0501@1|root,COG0501@2|Bacteria,2G6UV@200795|Chloroflexi,27XQR@189775|Thermomicrobia	189775|Thermomicrobia	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
WLSH3_k127_8587315_1	1183377.Py04_1038	5.005e-117	392.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8587315_13	195522.BD01_0626	6.452e-68	249.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8587315_27	648996.Theam_1507	2.689e-22	98.0	COG3743@1|root,COG3743@2|Bacteria,2G52I@200783|Aquificae	200783|Aquificae	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
WLSH3_k127_8587315_28	5759.rna_EHI_122870-1	2.186e-21	100.0	COG1100@1|root,KOG0087@2759|Eukaryota,3XFEK@554915|Amoebozoa	554915|Amoebozoa	U	Rab subfamily of small GTPases	-	-	-	-	-	-	-	-	-	-	-	-	Ras
WLSH3_k127_8587315_35	1341151.ASZU01000008_gene1605	3.376e-05	53.0	COG0526@1|root,COG0526@2|Bacteria,1VAS6@1239|Firmicutes,4HKGM@91061|Bacilli,27C59@186824|Thermoactinomycetaceae	91061|Bacilli	CO	Hydrogenase-1 expression protein HyaE	ytpP	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	-	Thioredoxin
WLSH3_k127_8587315_25	1122971.BAME01000005_gene741	1.044e-23	102.0	COG1773@1|root,COG1773@2|Bacteria,4NHF0@976|Bacteroidetes,2FUN6@200643|Bacteroidia,22YNA@171551|Porphyromonadaceae	976|Bacteroidetes	C	Rubredoxin	rubR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
WLSH3_k127_8587315_14	517418.Ctha_1337	2.098e-66	236.0	COG2135@1|root,COG2135@2|Bacteria,1FE5B@1090|Chlorobi	1090|Chlorobi	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
WLSH3_k127_8587315_36	525146.Ddes_1774	9.889e-05	48.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS,Ub-Mut7C
WLSH3_k127_8587315_31	234267.Acid_0626	7.926e-08	69.0	COG1470@1|root,COG2373@1|root,COG2931@1|root,COG3391@1|root,COG4886@1|root,COG5492@1|root,COG1470@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,COG5492@2|Bacteria,3Y49I@57723|Acidobacteria	57723|Acidobacteria	N	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,VCBS
WLSH3_k127_8587315_33	591019.Shell_0451	3.118e-07	67.0	COG1520@1|root,arCOG02492@2157|Archaea	2157|Archaea	M	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Big_5,CHB_HEX_C_1,PKD,PQQ_2,PQQ_3
WLSH3_k127_8587315_16	548477.HMPREF0294_0332	1.246e-63	254.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
WLSH3_k127_8587315_21	926550.CLDAP_39580	2.133e-34	142.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
WLSH3_k127_8587315_29	572478.Vdis_1802	2.41e-18	96.0	COG0454@1|root,arCOG00845@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
WLSH3_k127_8587315_8	439481.Aboo_0407	2.123e-79	286.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,3F35N@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_8587315_7	309803.CTN_1426	1.058e-93	317.0	COG0601@1|root,COG0601@2|Bacteria,2GBYF@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_8587315_10	403833.Pmob_1783	3.053e-75	273.0	COG1173@1|root,COG1173@2|Bacteria,2GCC1@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_8587315_6	521045.Kole_2049	5.199e-98	330.0	COG0444@1|root,COG0444@2|Bacteria,2GC44@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_8587315_3	1150474.JQJI01000020_gene1568	4.374e-115	379.0	COG4608@1|root,COG4608@2|Bacteria,2GC91@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_8587315_23	582899.Hden_2406	1.921e-26	125.0	COG1842@1|root,COG1842@2|Bacteria,1QW5I@1224|Proteobacteria,2TWNE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
WLSH3_k127_8587315_24	595494.Tola_0973	4.805e-25	121.0	COG5316@1|root,COG5316@2|Bacteria,1N0IJ@1224|Proteobacteria,1S6FA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
WLSH3_k127_8587315_2	1118054.CAGW01000024_gene451	9.137e-117	390.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,26SYE@186822|Paenibacillaceae	91061|Bacilli	E	peptidase M20	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
WLSH3_k127_8587315_20	1440774.Y900_001065	2.175e-41	173.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,23EV8@1762|Mycobacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_8587315_9	1499967.BAYZ01000132_gene305	1.781e-75	264.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_8587315_17	1499967.BAYZ01000132_gene306	9.96e-62	232.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_8587315_5	391009.Tmel_0561	2.05e-102	344.0	COG0444@1|root,COG0444@2|Bacteria,2GCDR@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_8587315_4	439481.Aboo_0845	2.779e-105	351.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
WLSH3_k127_8587315_37	998088.B565_3888	0.0008007	44.0	2ES0Z@1|root,33JK1@2|Bacteria,1NHKR@1224|Proteobacteria,1SI94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	VC0074	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8587315_0	1348663.KCH_55710	2.831e-130	424.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,2M14Z@2063|Kitasatospora	201174|Actinobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
WLSH3_k127_8587315_19	1131266.ARWQ01000002_gene689	6.295e-48	185.0	COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
WLSH3_k127_8587315_18	1121085.AUCI01000028_gene2360	2.556e-57	210.0	COG0329@1|root,COG0329@2|Bacteria,1UZPA@1239|Firmicutes,4HDAA@91061|Bacilli,1ZFBA@1386|Bacillus	91061|Bacilli	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
WLSH3_k127_8587315_32	262543.Exig_2670	2.255e-07	63.0	COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,4H9Q9@91061|Bacilli,3WFDU@539002|Bacillales incertae sedis	91061|Bacilli	EGP	Confers resistance to fosfomycin and deoxycholate	pmrA	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1,MFS_1_like,Sugar_tr
WLSH3_k127_8587315_15	515635.Dtur_1163	3.099e-65	237.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
WLSH3_k127_8587315_11	1297617.JPJD01000050_gene1947	5.126e-74	261.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,26887@186813|unclassified Clostridiales	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
WLSH3_k127_8692509_7	1125863.JAFN01000001_gene2593	1.645e-53	195.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_8692509_18	497964.CfE428DRAFT_3274	4.705e-10	73.0	COG0737@1|root,COG2374@1|root,COG4733@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,COG4733@2|Bacteria,46VVX@74201|Verrucomicrobia	74201|Verrucomicrobia	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
WLSH3_k127_8692509_10	161934.XP_010677114.1	4.337e-29	130.0	KOG0084@1|root,KOG0084@2759|Eukaryota,37JSX@33090|Viridiplantae,3GAR8@35493|Streptophyta	35493|Streptophyta	U	Ras-related protein	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_8692509_16	398512.JQKC01000016_gene2751	6.077e-14	81.0	COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia,3WJUP@541000|Ruminococcaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PAP2_3
WLSH3_k127_8692509_14	1408422.JHYF01000004_gene1563	7.841e-22	101.0	COG0346@1|root,COG0346@2|Bacteria,1VC53@1239|Firmicutes,24ICT@186801|Clostridia,36IP2@31979|Clostridiaceae	186801|Clostridia	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
WLSH3_k127_8692509_0	1094980.Mpsy_0782	1.548e-92	315.0	COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,2N9K8@224756|Methanomicrobia	224756|Methanomicrobia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
WLSH3_k127_8692509_6	86416.Clopa_0525	2.267e-56	207.0	COG1149@1|root,COG1149@2|Bacteria,1V767@1239|Firmicutes,24KWX@186801|Clostridia,36UKC@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulphur binding, subgroup	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9,Flavodoxin_5
WLSH3_k127_8692509_2	1499967.BAYZ01000137_gene110	2.536e-83	286.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
WLSH3_k127_8692509_15	997346.HMPREF9374_0764	9.385e-17	89.0	COG2020@1|root,COG2020@2|Bacteria,1TTRY@1239|Firmicutes,4IIPS@91061|Bacilli,27D8C@186824|Thermoactinomycetaceae	91061|Bacilli	O	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8692509_5	690850.Desaf_2977	9.277e-78	267.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2M9ST@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
WLSH3_k127_8692509_13	903818.KI912268_gene670	3.443e-22	107.0	COG2324@1|root,COG2324@2|Bacteria,3Y7JJ@57723|Acidobacteria	57723|Acidobacteria	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
WLSH3_k127_8692509_19	526226.Gbro_2447	3.418e-09	69.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4GC83@85026|Gordoniaceae	201174|Actinobacteria	U	Major Facilitator Superfamily	stp	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_8692509_20	660470.Theba_2150	5.274e-07	57.0	COG1765@1|root,COG1765@2|Bacteria,2GE9P@200918|Thermotogae	200918|Thermotogae	O	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
WLSH3_k127_8692509_8	869210.Marky_0906	1.279e-52	199.0	COG1619@1|root,COG1619@2|Bacteria,1WMQP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	LD-carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S66
WLSH3_k127_8692509_9	330779.Saci_1059	2.066e-31	138.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRTC@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WLSH3_k127_8692509_4	1236689.MMALV_03800	1.191e-79	274.0	COG0489@1|root,arCOG00585@2157|Archaea,2XTU2@28890|Euryarchaeota,3F2JA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
WLSH3_k127_8692509_1	1094980.Mpsy_0774	1.289e-90	306.0	COG1149@1|root,arCOG04073@2157|Archaea,2XWI1@28890|Euryarchaeota,2N9GG@224756|Methanomicrobia	224756|Methanomicrobia	D	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
WLSH3_k127_8692509_3	1121456.ATVA01000013_gene1085	4.307e-82	286.0	COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions,2WJ9M@28221|Deltaproteobacteria,2M7TE@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cobyrinic acid ac-diamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
WLSH3_k127_8692509_12	1209989.TepiRe1_0268	5.583e-27	115.0	COG1342@1|root,COG1342@2|Bacteria,1V5RE@1239|Firmicutes,25CFP@186801|Clostridia,42GRX@68295|Thermoanaerobacterales	186801|Clostridia	S	Belongs to the UPF0251 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
WLSH3_k127_8692509_11	429009.Adeg_1087	3.414e-28	120.0	COG1433@1|root,COG1433@2|Bacteria,1VFDZ@1239|Firmicutes,24R8N@186801|Clostridia,42GPN@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
WLSH3_k127_8692509_21	381764.Fnod_1447	8.17e-05	47.0	COG1433@1|root,COG1433@2|Bacteria	2|Bacteria	S	nitrogen fixation	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
WLSH3_k127_8703116_1	536227.CcarbDRAFT_3720	4.419e-09	62.0	2D1AQ@1|root,32TA9@2|Bacteria,1VADA@1239|Firmicutes,24MZG@186801|Clostridia,36MDP@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8703116_0	315730.BcerKBAB4_2760	1.275e-16	87.0	2BTC8@1|root,32NI0@2|Bacteria,1V5S5@1239|Firmicutes	1239|Firmicutes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8703336_0	1365176.N186_06365	2.743e-37	151.0	COG0496@1|root,arCOG02303@2157|Archaea,2XQA4@28889|Crenarchaeota	28889|Crenarchaeota	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
WLSH3_k127_8703336_1	1463857.JOFZ01000002_gene5172	5.202e-05	57.0	COG4085@1|root,COG4412@1|root,COG4085@2|Bacteria,COG4412@2|Bacteria,2GP86@201174|Actinobacteria	201174|Actinobacteria	E	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
WLSH3_k127_8910749_48	4922.CAY71440	2.361e-13	83.0	COG1100@1|root,KOG0071@2759|Eukaryota,3A2CM@33154|Opisthokonta,3P36Y@4751|Fungi,3QVRS@4890|Ascomycota,3RUN9@4891|Saccharomycetes	4751|Fungi	U	Belongs to the small GTPase superfamily. Arf family	-	-	-	ko:K07977	-	-	-	-	ko00000,ko04031	-	-	-	Arf
WLSH3_k127_8910749_49	933801.Ahos_2164	1.273e-12	72.0	COG1599@1|root,arCOG01510@2157|Archaea,2XQQM@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
WLSH3_k127_8910749_55	1167006.UWK_02552	1.394e-06	57.0	COG3613@1|root,COG3613@2|Bacteria,1P3XX@1224|Proteobacteria,431PM@68525|delta/epsilon subdivisions,2WWDI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
WLSH3_k127_8910749_33	443143.GM18_1750	4.59e-43	170.0	COG0697@1|root,COG0697@2|Bacteria,1PIF3@1224|Proteobacteria,42SMV@68525|delta/epsilon subdivisions,2WPAJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_8910749_1	453591.Igni_0393	2.227e-188	599.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
WLSH3_k127_8910749_42	693661.Arcve_1631	9.203e-29	124.0	COG0467@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,2XXH5@28890|Euryarchaeota	28890|Euryarchaeota	T	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
WLSH3_k127_8910749_51	313606.M23134_06885	1.425e-09	68.0	COG0457@1|root,COG0642@1|root,COG2203@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,4PI91@976|Bacteroidetes,47UPB@768503|Cytophagia	976|Bacteroidetes	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
WLSH3_k127_8910749_59	937777.Deipe_0806	0.000464	54.0	COG1404@1|root,COG1404@2|Bacteria,1WMBP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
WLSH3_k127_8910749_43	1158338.JNLJ01000001_gene73	1.765e-25	109.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_8910749_8	69014.TK0517	1.079e-114	383.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
WLSH3_k127_8910749_34	1094980.Mpsy_1000	5.309e-42	166.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota,2N9J3@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GHMP kinase	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
WLSH3_k127_8910749_15	490899.DKAM_0336	7.565e-84	287.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
WLSH3_k127_8910749_26	529709.PYCH_07360	1.326e-51	196.0	COG1893@1|root,arCOG04139@2157|Archaea,2XTBD@28890|Euryarchaeota,243P9@183968|Thermococci	183968|Thermococci	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
WLSH3_k127_8910749_39	304371.MCP_2530	1.39e-34	141.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2N9QR@224756|Methanomicrobia	224756|Methanomicrobia	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_8910749_25	945713.IALB_0605	8.604e-52	200.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
WLSH3_k127_8910749_38	743525.TSC_c09700	9.645e-35	144.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
WLSH3_k127_8910749_23	985053.VMUT_2008	1.554e-53	197.0	COG1402@1|root,arCOG04536@2157|Archaea,2XQVG@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
WLSH3_k127_8910749_45	1219084.AP014508_gene96	2.519e-19	97.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_8910749_2	368408.Tpen_0613	9.186e-172	564.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WLSH3_k127_8910749_13	391623.TERMP_00518	6.703e-88	306.0	COG0624@1|root,arCOG01107@2157|Archaea,2Y315@28890|Euryarchaeota,242ZX@183968|Thermococci	183968|Thermococci	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
WLSH3_k127_8910749_0	1343739.PAP_00935	1.863e-254	820.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,242NA@183968|Thermococci	183968|Thermococci	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
WLSH3_k127_8910749_47	351160.RRC103	2.246e-16	82.0	COG4997@1|root,arCOG03005@2157|Archaea,2XZRW@28890|Euryarchaeota,2NB8H@224756|Methanomicrobia	224756|Methanomicrobia	I	bis(5'-adenosyl)-triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WLSH3_k127_8910749_3	579137.Metvu_0790	5.217e-155	506.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
WLSH3_k127_8910749_18	572479.Hprae_0499	1.165e-75	269.0	COG2407@1|root,COG2407@2|Bacteria,1TPEK@1239|Firmicutes,24BY2@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8910749_21	485913.Krac_5774	1.117e-54	203.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
WLSH3_k127_8910749_17	70601.3256635	3.127e-76	273.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8910749_37	215803.DB30_5318	2.168e-35	151.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,42RID@68525|delta/epsilon subdivisions,2WN9N@28221|Deltaproteobacteria,2YUME@29|Myxococcales	28221|Deltaproteobacteria	S	Zn-dependent proteases and their inactivated homologs	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_8910749_32	1056816.JAFQ01000004_gene4261	1.831e-46	181.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4FUCC@85025|Nocardiaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	crtE	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
WLSH3_k127_8910749_52	573061.Clocel_1305	4.051e-08	66.0	COG1387@1|root,COG3250@1|root,COG5263@1|root,COG5492@1|root,COG1387@2|Bacteria,COG3250@2|Bacteria,COG5263@2|Bacteria,COG5492@2|Bacteria,1UIHY@1239|Firmicutes,25FMJ@186801|Clostridia,36V3J@31979|Clostridiaceae	186801|Clostridia	EN	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
WLSH3_k127_8910749_46	717785.HYPMC_1063	1.303e-18	101.0	COG0389@1|root,COG0389@2|Bacteria,1NTDH@1224|Proteobacteria,2UNYG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332,Zn_dep_PLPC
WLSH3_k127_8910749_53	61459.XP_007779531.1	2.125e-07	64.0	2CSXJ@1|root,2RDMZ@2759|Eukaryota,3AIEW@33154|Opisthokonta,3PAAA@4751|Fungi,3R0WR@4890|Ascomycota,20GJ6@147545|Eurotiomycetes	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8910749_41	591019.Shell_0668	6.953e-32	144.0	COG4945@1|root,arCOG01310@2157|Archaea,arCOG03771@2157|Archaea,2XPP7@28889|Crenarchaeota	28889|Crenarchaeota	G	to be involved in regulation of amylopullulanase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C
WLSH3_k127_8910749_12	604354.TSIB_0222	6.408e-89	311.0	COG1840@1|root,arCOG00221@2157|Archaea,2Y33A@28890|Euryarchaeota,243E5@183968|Thermococci	183968|Thermococci	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
WLSH3_k127_8910749_7	604354.TSIB_0221	7.65e-118	404.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,242Z4@183968|Thermococci	183968|Thermococci	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
WLSH3_k127_8910749_11	511051.CSE_14410	8.038e-90	309.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	potA	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
WLSH3_k127_8910749_4	1220534.B655_1530	2.068e-145	484.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,23NJG@183925|Methanobacteria	183925|Methanobacteria	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
WLSH3_k127_8910749_19	1041930.Mtc_0091	1.707e-69	252.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2N99S@224756|Methanomicrobia	224756|Methanomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
WLSH3_k127_8910749_24	555079.Toce_0806	1.877e-53	196.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,42FJ0@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	metV	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
WLSH3_k127_8910749_16	795359.TOPB45_0396	1.477e-82	284.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	metF3	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
WLSH3_k127_8910749_27	1220534.B655_1102	5.343e-50	190.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
WLSH3_k127_8910749_30	420247.Msm_1010	1.519e-48	181.0	COG4063@1|root,arCOG03221@2157|Archaea,2XWSE@28890|Euryarchaeota,23PC8@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrA	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
WLSH3_k127_8910749_10	224719.Abm4_1518	5.62e-92	313.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
WLSH3_k127_8910749_5	647113.Metok_0214	8.035e-134	440.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,23Q29@183939|Methanococci	183939|Methanococci	S	Methanogenesis marker protein 14	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
WLSH3_k127_8910749_20	1094980.Mpsy_1814	5.41e-61	219.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
WLSH3_k127_8910749_22	419665.Maeo_0157	3.559e-54	208.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23QR0@183939|Methanococci	183939|Methanococci	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
WLSH3_k127_8910749_9	1459636.NTE_00007	1.208e-106	374.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
WLSH3_k127_8910749_50	751944.HALDL1_00015	6.385e-10	63.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XXYB@28890|Euryarchaeota,23WG9@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_8910749_40	5478.XP_445802.1	2.534e-32	134.0	KOG0394@1|root,KOG0394@2759|Eukaryota,38C61@33154|Opisthokonta,3NWMV@4751|Fungi,3QKEZ@4890|Ascomycota,3RSFU@4891|Saccharomycetes,3RYBT@4893|Saccharomycetaceae	4751|Fungi	U	to Saccharomyces cerevisiae YPT7 (YML001W)	-	GO:0000011,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005773,GO:0005774,GO:0006810,GO:0006873,GO:0006885,GO:0006886,GO:0006892,GO:0006896,GO:0006897,GO:0006914,GO:0006996,GO:0007033,GO:0007034,GO:0007035,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010638,GO:0010639,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016236,GO:0016237,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019725,GO:0019867,GO:0023052,GO:0030003,GO:0030004,GO:0030641,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032258,GO:0032889,GO:0033036,GO:0033043,GO:0033365,GO:0034613,GO:0034727,GO:0035556,GO:0042144,GO:0042147,GO:0042592,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044088,GO:0044090,GO:0044232,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044429,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044804,GO:0045184,GO:0045851,GO:0046907,GO:0048193,GO:0048284,GO:0048308,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0051641,GO:0051649,GO:0051716,GO:0055067,GO:0055080,GO:0055082,GO:0061024,GO:0061025,GO:0061191,GO:0061192,GO:0061919,GO:0065007,GO:0065008,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0072665,GO:0097576,GO:0098588,GO:0098657,GO:0098771,GO:0098805,GO:0098852,GO:1990816	-	ko:K07897	ko04137,ko04138,ko04140,ko04144,ko04145,ko05132,ko05146,ko05152,map04137,map04138,map04140,map04144,map04145,map05132,map05146,map05152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_8910749_29	46234.ANA_C12029	3.866e-49	192.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HJRR@1161|Nostocales	1117|Cyanobacteria	S	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,WD40
WLSH3_k127_8910749_36	59689.fgenesh1_pm.C_scaffold_7002039	7.809e-39	151.0	COG1100@1|root,KOG0098@2759|Eukaryota,37PZ3@33090|Viridiplantae,3G88B@35493|Streptophyta,3HS61@3699|Brassicales	35493|Streptophyta	U	Ras-related protein	-	GO:0000139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0012505,GO:0016020,GO:0031090,GO:0031984,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0098588,GO:0098791	-	ko:K07877,ko:K07976	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_8910749_58	932678.THERU_06275	0.0003668	48.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
WLSH3_k127_8910749_54	1220534.B655_1011	1.141e-06	55.0	COG0526@1|root,arCOG01218@2157|Archaea,2Y8A7@28890|Euryarchaeota,23P7K@183925|Methanobacteria	183925|Methanobacteria	O	Redox-active disulfide protein 1	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
WLSH3_k127_8910749_28	246969.TAM4_666	3.396e-49	184.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
WLSH3_k127_8910749_57	768679.TTX_1053	7.082e-05	53.0	COG0467@1|root,arCOG05482@2157|Archaea,2XQX8@28889|Crenarchaeota	28889|Crenarchaeota	T	COGs COG0467 RecA-superfamily ATPase implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
WLSH3_k127_8910749_6	387631.Asulf_00696	2.81e-133	450.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,246YG@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WLSH3_k127_8910749_14	593117.TGAM_2149	2.867e-86	292.0	COG0110@1|root,arCOG01848@2157|Archaea,2XWJM@28890|Euryarchaeota,242NY@183968|Thermococci	183968|Thermococci	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WLSH3_k127_8910749_35	589924.Ferp_1176	1.954e-40	157.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
WLSH3_k127_8910749_31	269797.Mbar_A0890	6.89e-48	178.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
WLSH3_k127_8910749_56	572546.Arcpr_1284	2.038e-05	50.0	COG0526@1|root,arCOG02713@2157|Archaea	2157|Archaea	C	Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0055114	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
WLSH3_k127_8910749_44	572546.Arcpr_0010	5.198e-22	100.0	COG1328@1|root,COG2074@1|root,arCOG01967@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,NRDD
WLSH3_k127_8911196_0	1121472.AQWN01000006_gene1831	5.666e-180	584.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2
WLSH3_k127_8911196_7	237368.SCABRO_01879	2.022e-20	97.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
WLSH3_k127_8911196_5	439235.Dalk_5067	7.535e-57	208.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MJQR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	heterodisulfide reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
WLSH3_k127_8911196_1	523845.AQXV01000051_gene1217	6.037e-147	477.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
WLSH3_k127_8911196_2	386456.JQKN01000010_gene695	1.335e-136	454.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23NUK@183925|Methanobacteria	183925|Methanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
WLSH3_k127_8911196_6	1499967.BAYZ01000171_gene5568	4.519e-50	183.0	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	hdrG	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
WLSH3_k127_8911196_4	523845.AQXV01000050_gene1004	1.313e-60	220.0	COG1941@1|root,arCOG02472@2157|Archaea,2XVJ0@28890|Euryarchaeota,23QEJ@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	vhuG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
WLSH3_k127_8911196_3	579137.Metvu_1488	3.747e-133	437.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23QHR@183939|Methanococci	183939|Methanococci	C	PFAM Nickel-dependent hydrogenase, large subunit	vhuA	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
WLSH3_k127_8964392_7	3055.EDP04111	1.039e-06	61.0	KOG3861@1|root,KOG3861@2759|Eukaryota,37U36@33090|Viridiplantae,34HUZ@3041|Chlorophyta	3041|Chlorophyta	W	Intraflagellar transport protein IFT52	-	-	-	ko:K19681	-	-	-	-	ko00000,ko03036	-	-	-	ABC_transp_aux
WLSH3_k127_8964392_4	411463.EUBVEN_01550	5.284e-28	119.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,25WUY@186806|Eubacteriaceae	186801|Clostridia	FG	Psort location Cytoplasmic, score	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
WLSH3_k127_8964392_5	457570.Nther_2030	2.21e-26	114.0	COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
WLSH3_k127_8964392_0	572478.Vdis_1836	1.563e-205	673.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
WLSH3_k127_8964392_3	234267.Acid_2435	1.917e-77	276.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_8964392_2	865861.AZSU01000002_gene2618	5.38e-113	379.0	COG0863@1|root,COG0863@2|Bacteria,1TPR7@1239|Firmicutes,24A3P@186801|Clostridia,36E8V@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
WLSH3_k127_8964392_6	1041930.Mtc_1611	1.397e-10	64.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota,2NBEM@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WLSH3_k127_8964392_1	573064.Mefer_1488	1.44e-132	436.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,23QJI@183939|Methanococci	183939|Methanococci	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
WLSH3_k127_8964392_8	7176.CPIJ010671-PA	5.017e-06	57.0	KOG3341@1|root,KOG3341@2759|Eukaryota,38FCZ@33154|Opisthokonta,3B9KQ@33208|Metazoa,3CUGF@33213|Bilateria,41UN2@6656|Arthropoda,3SFS4@50557|Insecta,44XJI@7147|Diptera,45EXT@7148|Nematocera	33208|Metazoa	U	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs	SNF8	GO:0000003,GO:0000578,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031326,GO:0031410,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045921,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:1903506,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:2000112,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
WLSH3_k127_9106793_0	926569.ANT_18640	3.373e-251	796.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
WLSH3_k127_9106793_1	565033.GACE_1879	3.401e-75	275.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,246Q1@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_9106793_3	579137.Metvu_0472	1.624e-34	143.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,23QV9@183939|Methanococci	183939|Methanococci	S	ZPR1-like zinc finger protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
WLSH3_k127_9106793_2	1304880.JAGB01000002_gene1803	6.291e-72	251.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_9188134_2	1121472.AQWN01000011_gene1255	1.237e-177	571.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,26167@186807|Peptococcaceae	186801|Clostridia	C	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
WLSH3_k127_9188134_1	324057.Pjdr2_1891	1.796e-193	615.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HVE0@91061|Bacilli,271P8@186822|Paenibacillaceae	91061|Bacilli	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_9188134_6	1341151.ASZU01000008_gene1425	1.444e-74	259.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,27BD2@186824|Thermoactinomycetaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
WLSH3_k127_9188134_5	338963.Pcar_1573	5.19e-108	364.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42PAM@68525|delta/epsilon subdivisions,2WJZW@28221|Deltaproteobacteria,43RYK@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_9188134_3	1121405.dsmv_1298	1.163e-127	419.0	COG1032@1|root,COG1032@2|Bacteria,1PTN9@1224|Proteobacteria,42MG9@68525|delta/epsilon subdivisions,2WJYU@28221|Deltaproteobacteria,2MIRY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_9188134_9	694569.D7S_01607	6.686e-18	98.0	COG1073@1|root,COG1073@2|Bacteria,1N8YB@1224|Proteobacteria,1S74C@1236|Gammaproteobacteria,1Y7QS@135625|Pasteurellales	135625|Pasteurellales	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
WLSH3_k127_9188134_10	118168.MC7420_3739	2.074e-10	66.0	COG1266@1|root,COG1266@2|Bacteria,1G9T4@1117|Cyanobacteria	1117|Cyanobacteria	S	CAAX amino terminal protease family	-	-	-	-	-	-	-	-	-	-	-	-	Abi
WLSH3_k127_9188134_4	293826.Amet_1912	1.318e-127	414.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,24BVW@186801|Clostridia,36GH5@31979|Clostridiaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
WLSH3_k127_9188134_11	134676.ACPL_7972	1.263e-08	66.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4D8MC@85008|Micromonosporales	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
WLSH3_k127_9188134_12	96561.Dole_0077	0.0001124	47.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM carboxyl transferase	-	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
WLSH3_k127_9188134_7	485913.Krac_12092	1.42e-32	128.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
WLSH3_k127_9188134_8	864702.OsccyDRAFT_1490	9.71e-25	108.0	COG3654@1|root,COG3654@2|Bacteria,1G781@1117|Cyanobacteria,1HBJW@1150|Oscillatoriales	1117|Cyanobacteria	S	Fic/DOC family	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
WLSH3_k127_9188134_0	639282.DEFDS_1228	1.038e-227	715.0	COG4799@1|root,COG4799@2|Bacteria,2GEP0@200930|Deferribacteres	200930|Deferribacteres	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
WLSH3_k127_9231301_25	1536774.H70357_12160	0.0003098	51.0	COG1708@1|root,COG1708@2|Bacteria,1V56P@1239|Firmicutes,4HU2Z@91061|Bacilli,26T09@186822|Paenibacillaceae	91061|Bacilli	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
WLSH3_k127_9231301_2	1125863.JAFN01000001_gene2044	1.658e-194	625.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
WLSH3_k127_9231301_6	224325.AF_0367	1.89e-84	295.0	COG0477@1|root,arCOG00147@2157|Archaea,2XTS8@28890|Euryarchaeota,246N5@183980|Archaeoglobi	183980|Archaeoglobi	G	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
WLSH3_k127_9231301_0	370438.PTH_2131	9.325e-263	824.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
WLSH3_k127_9231301_4	1382304.JNIL01000001_gene3479	1.725e-139	454.0	COG2355@1|root,COG2355@2|Bacteria,1TRNQ@1239|Firmicutes,4HEBU@91061|Bacilli	91061|Bacilli	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
WLSH3_k127_9231301_15	1121468.AUBR01000028_gene1506	7.46e-42	165.0	COG1149@1|root,COG1149@2|Bacteria,1VDSQ@1239|Firmicutes,24NTS@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WLSH3_k127_9231301_23	1487923.DP73_06490	1.675e-09	63.0	COG1146@1|root,COG1146@2|Bacteria,1W2AI@1239|Firmicutes,25709@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
WLSH3_k127_9231301_10	1128398.Curi_c06920	8.775e-51	192.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,268N0@186813|unclassified Clostridiales	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
WLSH3_k127_9231301_20	1078020.KEK_14828	2.168e-16	84.0	2EX84@1|root,33QIW@2|Bacteria,2ICDC@201174|Actinobacteria	201174|Actinobacteria	S	PEP-utilising enzyme, mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers
WLSH3_k127_9231301_18	1112204.GPOL_c00750	2.636e-18	97.0	2EX84@1|root,33QIW@2|Bacteria,2ICDC@201174|Actinobacteria	201174|Actinobacteria	S	PEP-utilising enzyme, mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers
WLSH3_k127_9231301_17	1112204.GPOL_c15200	9.219e-25	115.0	2ERKW@1|root,33J6D@2|Bacteria,2I7F1@201174|Actinobacteria,4GGVG@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9231301_9	485914.Hmuk_1186	1.946e-57	221.0	COG1073@1|root,arCOG01661@2157|Archaea	2157|Archaea	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
WLSH3_k127_9231301_8	398767.Glov_0517	1.046e-67	247.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,43TQX@69541|Desulfuromonadales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
WLSH3_k127_9231301_12	309801.trd_1579	1.301e-48	187.0	COG0407@1|root,COG0407@2|Bacteria,2G6BE@200795|Chloroflexi,27XYH@189775|Thermomicrobia	189775|Thermomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
WLSH3_k127_9231301_3	671143.DAMO_2750	3.2e-158	517.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2NNNK@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase X family	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
WLSH3_k127_9231301_13	272558.10174509	7.679e-47	180.0	28JAJ@1|root,2Z95C@2|Bacteria,1UBFJ@1239|Firmicutes,4HHFM@91061|Bacilli,1ZR76@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9231301_22	192952.MM_2352	2.274e-15	79.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y49G@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9231301_11	386456.JQKN01000002_gene2749	8.199e-50	187.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,23NRI@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WLSH3_k127_9231301_1	1459636.NTE_03216	3.061e-244	781.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
WLSH3_k127_9231301_16	330214.NIDE3895	1.859e-27	117.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
WLSH3_k127_9231301_19	158190.SpiGrapes_2343	5.041e-17	86.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	-	-	-	-	-	-	-	-	-	OsmC
WLSH3_k127_9231301_14	1305836.AXVE01000001_gene2681	7.881e-45	172.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4IQCJ@91061|Bacilli	91061|Bacilli	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_9231301_21	926550.CLDAP_28250	2.518e-16	84.0	COG3439@1|root,COG3439@2|Bacteria,2G72I@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
WLSH3_k127_9231301_7	1047013.AQSP01000125_gene2640	6.409e-72	257.0	COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria	2|Bacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1,Sugar_tr
WLSH3_k127_9231301_24	1365176.N186_09005	1.844e-07	59.0	COG3432@1|root,arCOG01055@2157|Archaea,2XREG@28889|Crenarchaeota	28889|Crenarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
WLSH3_k127_9231301_5	1379698.RBG1_1C00001G0798	1.692e-133	457.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	HEAT_2,Peptidase_M1
WLSH3_k127_9282783_0	368408.Tpen_0881	1.394e-117	389.0	COG1313@1|root,arCOG00934@2157|Archaea,2XPK3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
WLSH3_k127_9282783_1	864051.BurJ1DRAFT_1605	2.978e-16	81.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2VVZH@28216|Betaproteobacteria,1KMKF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	hypC1	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
WLSH3_k127_9332440_16	926569.ANT_18640	6.156e-25	107.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
WLSH3_k127_9332440_9	768670.Calni_0847	1.227e-64	235.0	COG2319@1|root,COG4249@1|root,COG2319@2|Bacteria,COG4249@2|Bacteria,2GG9I@200930|Deferribacteres	200930|Deferribacteres	G	peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
WLSH3_k127_9332440_21	6334.EFV58043	0.0001531	49.0	COG1405@1|root,KOG1598@2759|Eukaryota,38D3H@33154|Opisthokonta,3BC1I@33208|Metazoa,3CRPK@33213|Bilateria,40CBF@6231|Nematoda	33208|Metazoa	K	Brf1-like TBP-binding domain	BRF1	GO:0000126,GO:0000976,GO:0000992,GO:0001006,GO:0001016,GO:0001032,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006359,GO:0006383,GO:0006384,GO:0006399,GO:0006725,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009303,GO:0009304,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016072,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043487,GO:0043488,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044798,GO:0045893,GO:0045935,GO:0045945,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0061013,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0080090,GO:0090304,GO:0090576,GO:0097159,GO:0097659,GO:0098781,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903311,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K15196	-	-	-	-	ko00000,ko03021	-	-	-	BRF1,TFIIB,TF_Zn_Ribbon
WLSH3_k127_9332440_15	673860.AciM339_0363	3.104e-33	145.0	COG0477@1|root,arCOG00135@2157|Archaea,2XYRS@28890|Euryarchaeota,3F35J@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,MFS_3
WLSH3_k127_9332440_10	387631.Asulf_00767	1.643e-48	200.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,245Y7@183980|Archaeoglobi	183980|Archaeoglobi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
WLSH3_k127_9332440_19	77586.LPERR01G07510.1	2.172e-09	69.0	COG0464@1|root,KOG0737@2759|Eukaryota,37IX2@33090|Viridiplantae,3GC4V@35493|Streptophyta,3KVTA@4447|Liliopsida,3ICZ1@38820|Poales	35493|Streptophyta	O	Holliday junction DNA helicase ruvB N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	AAA
WLSH3_k127_9332440_7	1349822.NSB1T_02885	7.553e-77	279.0	COG0714@1|root,COG0714@2|Bacteria,4PAE8@976|Bacteroidetes,2FWQG@200643|Bacteroidia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
WLSH3_k127_9332440_14	866771.HMPREF9296_0494	2.639e-35	153.0	COG2304@1|root,COG2304@2|Bacteria,4P02M@976|Bacteroidetes,2FX22@200643|Bacteroidia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
WLSH3_k127_9332440_5	1183377.Py04_1133	8.967e-94	316.0	COG0543@1|root,arCOG02199@2157|Archaea,2XTVJ@28890|Euryarchaeota,243NE@183968|Thermococci	183968|Thermococci	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	1.8.1.19	ko:K20203	-	-	-	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind
WLSH3_k127_9332440_1	246194.CHY_1991	3.364e-193	613.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
WLSH3_k127_9332440_8	604354.TSIB_0222	4.86e-70	259.0	COG1840@1|root,arCOG00221@2157|Archaea,2Y33A@28890|Euryarchaeota,243E5@183968|Thermococci	183968|Thermococci	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
WLSH3_k127_9332440_4	985053.VMUT_1584	4.42e-109	370.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
WLSH3_k127_9332440_18	246969.TAM4_775	7.33e-21	105.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2440N@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
WLSH3_k127_9332440_22	243232.MJ_1030	0.000251	53.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23R2U@183939|Methanococci	183939|Methanococci	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
WLSH3_k127_9332440_12	415426.Hbut_1243	7.551e-41	160.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
WLSH3_k127_9332440_11	444158.MmarC6_1459	1.814e-43	162.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_9332440_3	192952.MM_0870	2.474e-132	432.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
WLSH3_k127_9332440_2	877455.Metbo_1378	3.174e-138	448.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
WLSH3_k127_9332440_13	1041930.Mtc_2205	3.969e-38	160.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,2N9WJ@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM asparagine synthase	asnB-2	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
WLSH3_k127_9332440_23	4432.XP_010253205.1	0.0007077	51.0	COG5029@1|root,KOG0367@2759|Eukaryota,37MPB@33090|Viridiplantae,3G8D1@35493|Streptophyta	35493|Streptophyta	O	Geranylgeranyl transferase type-1 subunit	-	GO:0001101,GO:0003674,GO:0003824,GO:0004659,GO:0004661,GO:0004662,GO:0004663,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005953,GO:0005968,GO:0006464,GO:0006807,GO:0006950,GO:0007275,GO:0008150,GO:0008152,GO:0008270,GO:0008284,GO:0008318,GO:0009414,GO:0009415,GO:0009555,GO:0009628,GO:0009719,GO:0009725,GO:0009733,GO:0009737,GO:0009787,GO:0009788,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010035,GO:0010556,GO:0010558,GO:0010605,GO:0010646,GO:0010648,GO:0016740,GO:0016765,GO:0018342,GO:0018344,GO:0019222,GO:0019538,GO:0022622,GO:0023051,GO:0023057,GO:0032501,GO:0032502,GO:0032991,GO:0033993,GO:0034097,GO:0036211,GO:0042127,GO:0042221,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045787,GO:0046872,GO:0046914,GO:0048229,GO:0048364,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051726,GO:0051769,GO:0051771,GO:0060255,GO:0065007,GO:0071704,GO:0097305,GO:0097354,GO:0099402,GO:0140096,GO:1901419,GO:1901420,GO:1901564,GO:1901700,GO:1902494,GO:1905957,GO:1905958,GO:1990234	2.5.1.59	ko:K11713	-	-	-	-	ko00000,ko01000,ko01006	-	-	-	Prenyltrans
WLSH3_k127_9332440_6	589924.Ferp_2549	1.923e-80	278.0	COG0492@1|root,arCOG01296@2157|Archaea,2XTJW@28890|Euryarchaeota,24639@183980|Archaeoglobi	183980|Archaeoglobi	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WLSH3_k127_9332440_17	591019.Shell_1086	3.926e-23	110.0	COG4028@1|root,arCOG04328@2157|Archaea,2XQGW@28889|Crenarchaeota	28889|Crenarchaeota	S	P-loop ATPase GTPase	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9332440_0	456442.Mboo_0199	3.213e-196	626.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
WLSH3_k127_9332440_20	448385.sce9115	4.526e-08	54.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2YUKJ@29|Myxococcales	28221|Deltaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2,4.3.1.1	ko:K01679,ko:K01744	ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R00490,R01082	RC00316,RC00443,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
WLSH3_k127_9434322_2	573064.Mefer_0244	2.569e-99	338.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,23QBT@183939|Methanococci	183939|Methanococci	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
WLSH3_k127_9434322_6	439235.Dalk_2542	2.503e-15	85.0	COG0778@1|root,COG1143@1|root,COG0778@2|Bacteria,COG1143@2|Bacteria,1R4E3@1224|Proteobacteria,42RVJ@68525|delta/epsilon subdivisions,2WNCQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Nitroreductase
WLSH3_k127_9434322_1	246194.CHY_1732	4.686e-101	342.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42I2K@68295|Thermoanaerobacterales	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
WLSH3_k127_9434322_0	1382356.JQMP01000003_gene1745	4.807e-112	374.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi,27YZ2@189775|Thermomicrobia	189775|Thermomicrobia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
WLSH3_k127_9434322_7	589924.Ferp_2324	4.108e-14	77.0	COG1545@1|root,arCOG01285@2157|Archaea,2Y17W@28890|Euryarchaeota	28890|Euryarchaeota	V	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_9434322_5	316274.Haur_0039	2.912e-16	88.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WLSH3_k127_9434322_4	1459636.NTE_01641	1.404e-21	104.0	arCOG03119@1|root,arCOG03119@2157|Archaea,41SMJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WLSH3_k127_9434322_3	926561.KB900618_gene118	3.495e-32	141.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,3WB0G@53433|Halanaerobiales	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
WLSH3_k127_9544099_8	309799.DICTH_0189	3.984e-87	297.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
WLSH3_k127_9544099_55	1365176.N186_07540	1.94e-05	56.0	COG0454@1|root,arCOG00844@2157|Archaea,2XQVD@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_9544099_51	1122135.KB893139_gene1374	9.195e-07	60.0	COG0454@1|root,COG0456@2|Bacteria,1RA6D@1224|Proteobacteria,2UC27@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0456 Acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_9544099_11	756499.Desde_0778	4.23e-76	271.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
WLSH3_k127_9544099_34	96561.Dole_0769	8.939e-31	138.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2X5UF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_9544099_21	1223543.GP2_046_00100	2.23e-47	183.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4GAMM@85026|Gordoniaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
WLSH3_k127_9544099_44	880073.Calab_1834	2.394e-15	87.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
WLSH3_k127_9544099_27	5932.XP_004039920.1	1.03e-38	151.0	KOG0084@1|root,KOG0084@2759|Eukaryota,3ZCZ3@5878|Ciliophora	5878|Ciliophora	U	Rab subfamily of small GTPases	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_9544099_14	398512.JQKC01000027_gene3915	8.491e-74	263.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WLSH3_k127_9544099_0	1121472.AQWN01000003_gene1517	1.478e-233	735.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,260X7@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM methylmalonyl-CoA mutase N-terminal domain	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
WLSH3_k127_9544099_23	643648.Slip_0757	2.68e-46	173.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,42K3H@68298|Syntrophomonadaceae	186801|Clostridia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
WLSH3_k127_9544099_35	717606.PaecuDRAFT_4203	1.41e-29	128.0	COG2227@1|root,COG2227@2|Bacteria,1UHU9@1239|Firmicutes,4HXCZ@91061|Bacilli,274IH@186822|Paenibacillaceae	91061|Bacilli	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_9544099_7	891968.Anamo_1264	6.091e-99	333.0	COG1071@1|root,COG1071@2|Bacteria,3TA5N@508458|Synergistetes	508458|Synergistetes	C	E1 component	pdhA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
WLSH3_k127_9544099_4	1121472.AQWN01000007_gene1130	2.62e-117	385.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
WLSH3_k127_9544099_9	1347087.CBYO010000016_gene2564	3.534e-83	291.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,4HDFT@91061|Bacilli	91061|Bacilli	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
WLSH3_k127_9544099_32	666510.ASAC_0548	2.772e-32	138.0	COG0095@1|root,arCOG01939@2157|Archaea,2XQFH@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
WLSH3_k127_9544099_42	694431.DESACE_06315	1.563e-18	89.0	COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,42U17@68525|delta/epsilon subdivisions,2WRNU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
WLSH3_k127_9544099_10	926550.CLDAP_22900	1.181e-78	275.0	COG1063@1|root,COG1063@2|Bacteria,2G6PM@200795|Chloroflexi	200795|Chloroflexi	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_9544099_49	2880.D8LCX9	3.744e-07	57.0	COG4886@1|root,KOG0443@1|root,KOG0443@2759|Eukaryota,KOG0444@2759|Eukaryota	2759|Eukaryota	T	actin filament severing	FLII	GO:0001703,GO:0003674,GO:0003779,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005856,GO:0005903,GO:0005912,GO:0005924,GO:0005925,GO:0006996,GO:0007010,GO:0007275,GO:0007369,GO:0007525,GO:0007527,GO:0008092,GO:0008150,GO:0009653,GO:0009790,GO:0009987,GO:0010004,GO:0010927,GO:0015630,GO:0016043,GO:0022607,GO:0030029,GO:0030036,GO:0030054,GO:0030055,GO:0030154,GO:0030239,GO:0031032,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032989,GO:0042692,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0048468,GO:0048598,GO:0048646,GO:0048856,GO:0048869,GO:0051014,GO:0051146,GO:0055001,GO:0055002,GO:0061061,GO:0070013,GO:0070161,GO:0070925,GO:0071840,GO:0097435,GO:0098862	-	-	-	-	-	-	-	-	-	-	Gelsolin,LRR_4,LRR_8
WLSH3_k127_9544099_43	768679.TTX_0103	1.194e-16	85.0	COG1257@1|root,arCOG05512@2157|Archaea,2XSJX@28889|Crenarchaeota	28889|Crenarchaeota	I	hydroxymethylglutaryl-CoA reductase (NADPH) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9544099_38	1288494.EBAPG3_18060	6.437e-21	103.0	COG0110@1|root,COG0110@2|Bacteria,1RBYA@1224|Proteobacteria,2VRA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
WLSH3_k127_9544099_36	523845.AQXV01000046_gene843	7.444e-26	121.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,23QRM@183939|Methanococci	183939|Methanococci	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,HI0933_like
WLSH3_k127_9544099_40	1459636.NTE_02874	2.024e-19	100.0	COG2404@1|root,arCOG00423@2157|Archaea	2157|Archaea	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_9544099_2	706587.Desti_1357	1.037e-137	459.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42Q2C@68525|delta/epsilon subdivisions,2WKNN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
WLSH3_k127_9544099_31	706587.Desti_1356	5.648e-33	136.0	COG1014@1|root,COG1014@2|Bacteria,1RJBM@1224|Proteobacteria,42T3A@68525|delta/epsilon subdivisions,2WPV1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Indolepyruvate ferredoxin oxidoreductase, beta subunit	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
WLSH3_k127_9544099_33	281687.CJA09928	7.992e-32	144.0	COG1100@1|root,KOG0097@2759|Eukaryota,38EZ9@33154|Opisthokonta,3BBM7@33208|Metazoa,3CZZI@33213|Bilateria,40B9A@6231|Nematoda,1KV0X@119089|Chromadorea,40S2M@6236|Rhabditida	33208|Metazoa	U	Rab subfamily of small GTPases	RAB14	GO:0000166,GO:0000323,GO:0001775,GO:0001845,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005773,GO:0005783,GO:0005791,GO:0005794,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006661,GO:0006793,GO:0006796,GO:0006810,GO:0006873,GO:0006885,GO:0006887,GO:0006892,GO:0006895,GO:0006897,GO:0006909,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007033,GO:0007040,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007264,GO:0007265,GO:0007589,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008543,GO:0008610,GO:0008654,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009987,GO:0010008,GO:0010033,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016324,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019637,GO:0019725,GO:0022607,GO:0023052,GO:0030003,GO:0030004,GO:0030100,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030140,GO:0030141,GO:0030641,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031489,GO:0031901,GO:0031982,GO:0031984,GO:0032456,GO:0032482,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0035556,GO:0035639,GO:0036094,GO:0036230,GO:0036477,GO:0042119,GO:0042175,GO:0042221,GO:0042592,GO:0042599,GO:0042742,GO:0043025,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043277,GO:0043299,GO:0043312,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044297,GO:0044344,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045017,GO:0045055,GO:0045176,GO:0045177,GO:0045202,GO:0045321,GO:0045335,GO:0045851,GO:0045995,GO:0046474,GO:0046486,GO:0046488,GO:0046903,GO:0046907,GO:0048193,GO:0048471,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050878,GO:0050896,GO:0051049,GO:0051128,GO:0051179,GO:0051234,GO:0051239,GO:0051452,GO:0051453,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0055037,GO:0055038,GO:0055067,GO:0055080,GO:0055082,GO:0060627,GO:0065007,GO:0065008,GO:0070820,GO:0070821,GO:0070848,GO:0070887,GO:0070925,GO:0071310,GO:0071363,GO:0071495,GO:0071704,GO:0071774,GO:0071840,GO:0071944,GO:0080171,GO:0090382,GO:0090383,GO:0090386,GO:0090387,GO:0090390,GO:0090407,GO:0097159,GO:0097208,GO:0097367,GO:0097458,GO:0097708,GO:0098542,GO:0098588,GO:0098590,GO:0098657,GO:0098771,GO:0098791,GO:0098805,GO:0099503,GO:1901265,GO:1901363,GO:1901576,GO:2000026	-	ko:K07881	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
WLSH3_k127_9544099_15	573064.Mefer_1307	1.832e-72	254.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,23QHW@183939|Methanococci	183939|Methanococci	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
WLSH3_k127_9544099_19	706587.Desti_5187	1.212e-51	193.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,42RKW@68525|delta/epsilon subdivisions,2X5I8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
WLSH3_k127_9544099_24	706587.Desti_5346	7.493e-45	175.0	COG0715@1|root,COG0715@2|Bacteria,1RHDX@1224|Proteobacteria,42V6G@68525|delta/epsilon subdivisions,2WRZJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	iAF987.Gmet_0996	NMT1_2
WLSH3_k127_9544099_53	439481.Aboo_0620	3.223e-06	59.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
WLSH3_k127_9544099_22	1121459.AQXE01000010_gene1976	9.768e-47	174.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2M92T@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
WLSH3_k127_9544099_37	1499967.BAYZ01000016_gene6492	7.77e-26	112.0	COG1144@1|root,COG1144@2|Bacteria,2NRX4@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase	porD	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00171,ko:K00172,ko:K19072	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,Fer4_21,POR
WLSH3_k127_9544099_3	1304880.JAGB01000004_gene1407	1.408e-123	407.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
WLSH3_k127_9544099_5	1184251.TCELL_1237	3.654e-104	347.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
WLSH3_k127_9544099_13	1382356.JQMP01000004_gene499	2.609e-74	265.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi,27Y3N@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
WLSH3_k127_9544099_18	319795.Dgeo_1506	1.196e-60	221.0	COG0584@1|root,COG0584@2|Bacteria,1WKK6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
WLSH3_k127_9544099_46	1459636.NTE_01195	4.044e-10	64.0	COG1522@1|root,arCOG01117@2157|Archaea	1459636.NTE_01195|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9544099_25	926550.CLDAP_35280	6.69e-43	167.0	COG0454@1|root,COG0456@2|Bacteria,2G91C@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_9544099_30	929556.Solca_2127	2.72e-33	135.0	COG2020@1|root,COG2020@2|Bacteria,4PGXX@976|Bacteroidetes,1IUNY@117747|Sphingobacteriia	976|Bacteroidetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
WLSH3_k127_9544099_1	1125863.JAFN01000001_gene2485	1.708e-168	544.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
WLSH3_k127_9544099_50	740709.A10D4_11746	4.185e-07	61.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,1S24Q@1236|Gammaproteobacteria,2QGMC@267893|Idiomarinaceae	1236|Gammaproteobacteria	EG	EamA-like transporter family	yyaM	-	-	-	-	-	-	-	-	-	-	-	EamA
WLSH3_k127_9544099_45	1042377.AFPJ01000009_gene191	1.886e-13	84.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria,465X7@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,GDE_C
WLSH3_k127_9544099_54	1038867.AXAY01000031_gene4220	1.453e-05	57.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,3JTPV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ABC-2 family transporter protein	MA20_09460	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
WLSH3_k127_9544099_29	515635.Dtur_0061	2.556e-37	159.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	ccmA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WLSH3_k127_9544099_28	284031.JNXD01000027_gene1477	2.552e-37	164.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
WLSH3_k127_9544099_26	362418.IW19_18395	4.963e-42	167.0	COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,1HZ6V@117743|Flavobacteriia,2NU6F@237|Flavobacterium	976|Bacteroidetes	V	Multidrug ABC transporter ATPase	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WLSH3_k127_9544099_6	1249975.JQLP01000003_gene76	2.369e-102	380.0	COG1361@1|root,COG3266@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1HZAG@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
WLSH3_k127_9544099_20	519442.Huta_1865	1.486e-49	206.0	arCOG00381@1|root,arCOG07561@1|root,arCOG00382@2157|Archaea,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota,23UWG@183963|Halobacteria	183963|Halobacteria	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
WLSH3_k127_9544099_16	69014.TK2264	3.473e-65	258.0	COG1800@1|root,arCOG07561@1|root,arCOG02164@2157|Archaea,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota,2435K@183968|Thermococci	183968|Thermococci	K	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
WLSH3_k127_9544099_52	1123257.AUFV01000003_gene1009	1.283e-06	58.0	COG3714@1|root,COG3714@2|Bacteria,1N6QN@1224|Proteobacteria,1TAFV@1236|Gammaproteobacteria,1X74T@135614|Xanthomonadales	135614|Xanthomonadales	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
WLSH3_k127_9544099_39	439481.Aboo_0471	1.38e-20	105.0	COG0457@1|root,arCOG05137@1|root,arCOG03038@2157|Archaea,arCOG05137@2157|Archaea,2XUNW@28890|Euryarchaeota,3F2VB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Tetratricopeptide repeat	-	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	TPR_1,TPR_12,TPR_16,TPR_2,TPR_8
WLSH3_k127_9544099_12	1121904.ARBP01000003_gene6365	1.249e-74	262.0	COG0498@1|root,COG0498@2|Bacteria,4NKWI@976|Bacteroidetes,47SIW@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
WLSH3_k127_9544099_56	309801.trd_0167	0.0007193	49.0	COG2153@1|root,COG2153@2|Bacteria,2G9IV@200795|Chloroflexi,27YGQ@189775|Thermomicrobia	189775|Thermomicrobia	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
WLSH3_k127_9544099_17	1191523.MROS_1829	1.934e-64	232.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
WLSH3_k127_9544099_48	374847.Kcr_0356	4.635e-08	65.0	arCOG05346@1|root,arCOG05346@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9544099_41	944565.HMPREF9127_0768	2.648e-19	95.0	290DM@1|root,2ZN2Z@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WLSH3_k127_9547513_24	766499.C357_16356	0.0001764	46.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VG6E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
WLSH3_k127_9547513_10	477974.Daud_0275	2.599e-52	194.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,2611M@186807|Peptococcaceae	186801|Clostridia	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
WLSH3_k127_9547513_21	646529.Desaci_1527	6.34e-06	57.0	COG0619@1|root,COG0619@2|Bacteria,1VGWI@1239|Firmicutes	1239|Firmicutes	P	PFAM Cobalt transport protein	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
WLSH3_k127_9547513_12	251221.35210852	5.057e-33	139.0	COG0310@1|root,COG0310@2|Bacteria,1G40K@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
WLSH3_k127_9547513_14	523850.TON_0150	2.946e-28	122.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,24407@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
WLSH3_k127_9547513_22	391165.GbCGDNIH1_2248	1.297e-05	57.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2JQH4@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
WLSH3_k127_9547513_20	179408.Osc7112_2482	2.971e-06	55.0	2DN4E@1|root,32VGA@2|Bacteria,1G7ZM@1117|Cyanobacteria,1HCGT@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9547513_0	240016.ABIZ01000001_gene2673	4.242e-134	446.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,46U7Q@74201|Verrucomicrobia,2ITXJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	NAD synthase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase,NAD_synthase
WLSH3_k127_9547513_18	374847.Kcr_0871	1.493e-13	74.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_11,HTH_24
WLSH3_k127_9547513_3	374847.Kcr_0873	2.145e-123	421.0	COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
WLSH3_k127_9547513_23	1122599.AUGR01000001_gene382	2.71e-05	53.0	2AIE8@1|root,318VP@2|Bacteria,1N3HJ@1224|Proteobacteria,1SB1R@1236|Gammaproteobacteria,1XM7K@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9547513_2	1265505.ATUG01000002_gene2429	4.844e-128	420.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_9547513_16	634498.mru_1950	9.083e-20	97.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,23NQ6@183925|Methanobacteria	183925|Methanobacteria	S	Pheromone shutdown	-	-	-	-	-	-	-	-	-	-	-	-	TraB
WLSH3_k127_9547513_8	453591.Igni_0355	1.961e-57	207.0	COG0378@1|root,arCOG01231@2157|Archaea,2XRY5@28889|Crenarchaeota	28889|Crenarchaeota	O	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	ko:K03189,ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
WLSH3_k127_9547513_17	573064.Mefer_0901	9.608e-16	83.0	COG3355@1|root,arCOG02242@2157|Archaea,2XY1Y@28890|Euryarchaeota,23R13@183939|Methanococci	183939|Methanococci	K	PFAM Transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
WLSH3_k127_9547513_13	1056495.Calag_0209	3.205e-29	129.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQNM@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
WLSH3_k127_9547513_9	269799.Gmet_1723	2.183e-56	202.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1R45R@1224|Proteobacteria,42MDG@68525|delta/epsilon subdivisions,2WKTC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9547513_11	415426.Hbut_1039	2.718e-49	186.0	COG0648@1|root,arCOG01894@2157|Archaea,2XPUX@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
WLSH3_k127_9547513_15	386456.JQKN01000002_gene2681	8.576e-21	106.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
WLSH3_k127_9547513_4	573064.Mefer_1023	1.319e-87	300.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23QG1@183939|Methanococci	183939|Methanococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	Intein_splicing,TFIIB,TF_Zn_Ribbon
WLSH3_k127_9547513_1	1042877.GQS_02650	1.235e-129	437.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,24339@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
WLSH3_k127_9547513_7	1041930.Mtc_0290	3.393e-60	225.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_9547513_5	1042877.GQS_08250	6.522e-79	280.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
WLSH3_k127_9547513_6	9823.ENSSSCP00000005264	8.8e-74	263.0	KOG0739@1|root,KOG0739@2759|Eukaryota,38D1Q@33154|Opisthokonta,3BCY8@33208|Metazoa,3DEB2@33213|Bilateria,48IEF@7711|Chordata,49EBQ@7742|Vertebrata,3JIWP@40674|Mammalia,4JCE8@91561|Cetartiodactyla	33208|Metazoa	O	IstB-like ATP binding protein	VPS4B	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
WLSH3_k127_9547513_19	6412.HelroP156379	9.937e-09	65.0	KOG4068@1|root,KOG4068@2759|Eukaryota,39S7B@33154|Opisthokonta,3B9CD@33208|Metazoa,3CVUB@33213|Bilateria	33208|Metazoa	H	Vacuolar protein-sorting-associated protein 25	VPS25	GO:0000003,GO:0000578,GO:0000814,GO:0001894,GO:0001932,GO:0001933,GO:0002009,GO:0002165,GO:0003002,GO:0003006,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006403,GO:0006469,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006897,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007163,GO:0007175,GO:0007176,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0007444,GO:0007483,GO:0007484,GO:0007485,GO:0007548,GO:0007552,GO:0007560,GO:0008104,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009653,GO:0009790,GO:0009791,GO:0009798,GO:0009880,GO:0009886,GO:0009887,GO:0009888,GO:0009892,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010469,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010669,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0019220,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022411,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030011,GO:0030154,GO:0030163,GO:0030539,GO:0031090,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032984,GO:0032991,GO:0033036,GO:0033365,GO:0033673,GO:0034613,GO:0035088,GO:0035090,GO:0035112,GO:0035126,GO:0035215,GO:0035239,GO:0035282,GO:0035295,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042127,GO:0042325,GO:0042326,GO:0042592,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043086,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043549,GO:0043632,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045184,GO:0045197,GO:0045199,GO:0045324,GO:0045450,GO:0045859,GO:0045936,GO:0046661,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048519,GO:0048523,GO:0048563,GO:0048569,GO:0048583,GO:0048585,GO:0048599,GO:0048608,GO:0048609,GO:0048707,GO:0048729,GO:0048731,GO:0048803,GO:0048805,GO:0048806,GO:0048808,GO:0048856,GO:0048869,GO:0048871,GO:0050678,GO:0050680,GO:0050730,GO:0050732,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0060249,GO:0060255,GO:0060429,GO:0060562,GO:0060810,GO:0060811,GO:0061097,GO:0061099,GO:0061245,GO:0061458,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070086,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090598,GO:0097352,GO:0097708,GO:0098588,GO:0098657,GO:0098796,GO:0098805,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:2000272	-	ko:K12189	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	ESCRT-II
WLSH3_k127_9636718_6	868131.MSWAN_0480	2.109e-73	259.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,23NIZ@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_9636718_16	344747.PM8797T_05885	1.399e-29	131.0	COG0726@1|root,COG1864@1|root,COG3209@1|root,COG3210@1|root,COG3386@1|root,COG3391@1|root,COG5276@1|root,COG0726@2|Bacteria,COG1864@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,COG5276@2|Bacteria,2IXF1@203682|Planctomycetes	203682|Planctomycetes	M	Bacterial pre-peptidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PPC
WLSH3_k127_9636718_9	319225.Plut_0971	7.435e-62	224.0	COG1194@1|root,COG1194@2|Bacteria,1FD5V@1090|Chlorobi	1090|Chlorobi	L	HhH-GPD family	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
WLSH3_k127_9636718_18	36331.EPrPI00000015143	4.227e-26	123.0	COG3315@1|root,2RXVR@2759|Eukaryota,1MF64@121069|Pythiales	121069|Pythiales	Q	O-methyltransferase. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	LCM
WLSH3_k127_9636718_5	469381.Dpep_1184	2.27e-79	273.0	COG0778@1|root,COG0778@2|Bacteria,3TC3E@508458|Synergistetes	508458|Synergistetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_9636718_13	756883.Halar_1126	1.995e-43	169.0	COG1794@1|root,arCOG02006@2157|Archaea	2157|Archaea	M	Hydantoin racemase	-	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
WLSH3_k127_9636718_17	314315.LCA_1481	2.898e-26	114.0	COG3613@1|root,COG3613@2|Bacteria,1V3SN@1239|Firmicutes,4HH4T@91061|Bacilli,3F6KR@33958|Lactobacillaceae	91061|Bacilli	F	Nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
WLSH3_k127_9636718_0	1209989.TepiRe1_0402	3.88e-197	629.0	COG5012@1|root,COG5012@2|Bacteria,1UZP9@1239|Firmicutes,24CTM@186801|Clostridia,42FUE@68295|Thermoanaerobacterales	186801|Clostridia	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Met_asp_mut_E
WLSH3_k127_9636718_4	697281.Mahau_2054	2.643e-91	315.0	COG0240@1|root,COG0240@2|Bacteria,1TUSI@1239|Firmicutes,249QW@186801|Clostridia,42FJR@68295|Thermoanaerobacterales	186801|Clostridia	C	NAD NADP octopine nopaline	odh	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	ApbA,NAD_Gly3P_dh_N,NAD_binding_2,Octopine_DH
WLSH3_k127_9636718_8	530564.Psta_4082	4.798e-63	242.0	COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,2IYH3@203682|Planctomycetes	203682|Planctomycetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Dockerin_1,SdrD_B
WLSH3_k127_9636718_15	765420.OSCT_0574	4.855e-36	141.0	COG2050@1|root,COG2050@2|Bacteria,2G9ZQ@200795|Chloroflexi,377IT@32061|Chloroflexia	32061|Chloroflexia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
WLSH3_k127_9636718_12	313606.M23134_05592	1.49e-52	197.0	COG2755@1|root,COG2755@2|Bacteria,4PB3H@976|Bacteroidetes,47V47@768503|Cytophagia	976|Bacteroidetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
WLSH3_k127_9636718_22	1254432.SCE1572_52590	7.525e-13	76.0	COG0454@1|root,COG0456@2|Bacteria,1Q9SP@1224|Proteobacteria,434K8@68525|delta/epsilon subdivisions,2WYXH@28221|Deltaproteobacteria,2Z0V7@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WLSH3_k127_9636718_11	1279009.ADICEAN_00373	5.013e-54	192.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,47PPC@768503|Cytophagia	976|Bacteroidetes	O	Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
WLSH3_k127_9636718_26	1237500.ANBA01000009_gene1210	2.939e-08	65.0	COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria,4EHQ1@85012|Streptosporangiales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	yqjI	-	-	-	-	-	-	-	-	-	-	-	PadR
WLSH3_k127_9636718_23	243164.DET0017	8.558e-10	61.0	2BQDM@1|root,32J8W@2|Bacteria,2GB0B@200795|Chloroflexi,34DPG@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9636718_3	515635.Dtur_1811	2.06e-109	363.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
WLSH3_k127_9636718_19	69395.JQLZ01000006_gene2054	3.947e-22	101.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,2UJHW@28211|Alphaproteobacteria,2KJ5I@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WLSH3_k127_9636718_20	1370120.AUWR01000047_gene2154	4.993e-22	109.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,2360Z@1762|Mycobacteriaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
WLSH3_k127_9636718_25	351160.RCIX2683	6.321e-09	63.0	COG1970@1|root,arCOG05213@2157|Archaea	2157|Archaea	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
WLSH3_k127_9636718_14	316274.Haur_4209	3.242e-41	162.0	COG1030@1|root,COG1030@2|Bacteria,2G8HI@200795|Chloroflexi,37796@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
WLSH3_k127_9636718_10	933262.AXAM01000035_gene2154	7.251e-57	211.0	2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria,2MNT8@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9636718_27	1121382.JQKG01000003_gene4238	2.706e-06	58.0	COG1082@1|root,COG1082@2|Bacteria,1WM3W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
WLSH3_k127_9636718_7	1303518.CCALI_01951	5.798e-64	226.0	COG0177@1|root,COG0177@2|Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
WLSH3_k127_9636718_21	304371.MCP_1412	1.047e-17	88.0	COG0426@1|root,arCOG00509@2157|Archaea,2XYDW@28890|Euryarchaeota,2N9PY@224756|Methanomicrobia	2157|Archaea	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5,Lactamase_B
WLSH3_k127_9636718_2	1304880.JAGB01000002_gene1804	1.653e-118	405.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_9636718_1	316274.Haur_3627	6.647e-148	489.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi,37630@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WLSH3_k127_9636718_28	868131.MSWAN_0789	3.918e-05	55.0	COG0640@1|root,arCOG00734@2157|Archaea,2XXHJ@28890|Euryarchaeota,23PQV@183925|Methanobacteria	183925|Methanobacteria	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WLSH3_k127_9685962_8	521045.Kole_2071	3.817e-68	244.0	COG0078@1|root,COG0078@2|Bacteria,2GCNA@200918|Thermotogae	200918|Thermotogae	E	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
WLSH3_k127_9685962_0	1041930.Mtc_1848	5.489e-126	412.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,2N9H8@224756|Methanomicrobia	224756|Methanomicrobia	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
WLSH3_k127_9685962_1	439481.Aboo_1252	1.267e-108	364.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,3F38V@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	oppD2	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_9685962_6	351160.LRC379	3.566e-97	333.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,2N9GM@224756|Methanomicrobia	224756|Methanomicrobia	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_9685962_4	351160.LRC378	3.446e-99	335.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota,2NAQG@224756|Methanomicrobia	224756|Methanomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_9685962_9	1121441.AUCX01000016_gene2365	9.262e-63	221.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2M9B4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WLSH3_k127_9685962_5	521045.Kole_1337	8.62e-98	332.0	COG0426@1|root,COG0426@2|Bacteria,2GCAS@200918|Thermotogae	200918|Thermotogae	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
WLSH3_k127_9685962_2	1173028.ANKO01000042_gene858	2.721e-101	361.0	COG2366@1|root,COG2366@2|Bacteria,1G4M5@1117|Cyanobacteria	1117|Cyanobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
WLSH3_k127_9685962_3	1184251.TCELL_1366	3.47e-100	337.0	COG0448@1|root,arCOG00912@2157|Archaea,2XPXX@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
WLSH3_k127_9685962_7	351160.LRC377	5.456e-71	263.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_9685962_11	867903.ThesuDRAFT_01499	6.534e-23	106.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WLSH3_k127_9685962_10	370438.PTH_2212	8.143e-34	138.0	COG2110@1|root,COG2755@1|root,COG2110@2|Bacteria,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,24N6X@186801|Clostridia,262J2@186807|Peptococcaceae	186801|Clostridia	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
WLSH3_k127_9721137_5	1455608.JDTH01000001_gene3585	0.0001302	55.0	COG1002@1|root,arCOG04814@1|root,arCOG02634@2157|Archaea,arCOG04814@2157|Archaea	2157|Archaea	V	type II restriction enzyme, methylase	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,N6_Mtase,TaqI_C
WLSH3_k127_9721137_4	1042877.GQS_07780	2.947e-33	147.0	COG0286@1|root,arCOG04814@1|root,arCOG02632@2157|Archaea,arCOG04814@2157|Archaea,2XVYV@28890|Euryarchaeota	28890|Euryarchaeota	V	COG1002 Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
WLSH3_k127_9721137_3	490899.DKAM_1384	2.062e-33	136.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
WLSH3_k127_9721137_2	933801.Ahos_0647	3.788e-41	157.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_9721137_1	573063.Metin_0748	2.756e-42	169.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23QKP@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
WLSH3_k127_9721137_0	224325.AF_2238	3.479e-115	379.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,245PX@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
WLSH3_k127_9958422_44	340177.Cag_1216	2.59e-19	92.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06039,ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE
WLSH3_k127_9958422_46	706587.Desti_3015	1.237e-18	87.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,42VCF@68525|delta/epsilon subdivisions,2WRI6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
WLSH3_k127_9958422_35	642492.Clole_0288	6.966e-31	137.0	COG0330@1|root,COG0330@2|Bacteria,1VT4N@1239|Firmicutes	1239|Firmicutes	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
WLSH3_k127_9958422_52	1173264.KI913949_gene4363	8.559e-10	69.0	COG4886@1|root,COG4886@2|Bacteria,1G4SR@1117|Cyanobacteria,1HAQW@1150|Oscillatoriales	1117|Cyanobacteria	G	Leucine-rich repeat	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_6,LRR_8
WLSH3_k127_9958422_2	266117.Rxyl_2910	1.568e-152	502.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
WLSH3_k127_9958422_22	1382356.JQMP01000001_gene792	3.601e-55	202.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi,27XFS@189775|Thermomicrobia	189775|Thermomicrobia	S	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
WLSH3_k127_9958422_26	926561.KB900618_gene411	2.179e-44	177.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia	186801|Clostridia	L	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_9958422_0	1123511.KB905867_gene220	1.003e-173	562.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,4H304@909932|Negativicutes	909932|Negativicutes	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
WLSH3_k127_9958422_37	493475.GARC_0328	2.455e-30	128.0	COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9958422_18	768671.ThimaDRAFT_1778	1.956e-72	256.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1X0CX@135613|Chromatiales	135613|Chromatiales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.25	ko:K17950	ko00270,map00270	-	R07634	RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
WLSH3_k127_9958422_32	1223545.GS4_11_01520	8.087e-33	139.0	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria,4GCX8@85026|Gordoniaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,VWA_CoxE
WLSH3_k127_9958422_24	525897.Dbac_1816	3.728e-47	178.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,42PPN@68525|delta/epsilon subdivisions,2WK8S@28221|Deltaproteobacteria,2M7WI@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
WLSH3_k127_9958422_48	595460.RRSWK_06497	5.17e-17	92.0	COG2159@1|root,COG2159@2|Bacteria,2IYMW@203682|Planctomycetes	203682|Planctomycetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
WLSH3_k127_9958422_3	399550.Smar_0236	1.9e-123	409.0	COG0402@1|root,arCOG00695@2157|Archaea,2XPV1@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
WLSH3_k127_9958422_17	926569.ANT_23500	3.854e-74	266.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
WLSH3_k127_9958422_53	573064.Mefer_0671	1.639e-08	63.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23QBG@183939|Methanococci	183939|Methanococci	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
WLSH3_k127_9958422_33	419610.Mext_4822	1.996e-32	141.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2TVK0@28211|Alphaproteobacteria,1JQZF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	geranylgeranyl reductase	bchP	-	1.3.1.111,1.3.1.83	ko:K10960	ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R11226,R11518	RC00212,RC00522,RC01823	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Lycopene_cycl,NAD_binding_8,Pyr_redox_2
WLSH3_k127_9958422_42	351160.RCIX1840	5.536e-21	96.0	COG0784@1|root,arCOG02391@2157|Archaea,2Y6EC@28890|Euryarchaeota,2NBEQ@224756|Methanomicrobia	224756|Methanomicrobia	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WLSH3_k127_9958422_54	1137268.AZXF01000016_gene1110	3.611e-08	59.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4EH2P@85012|Streptosporangiales	201174|Actinobacteria	T	ANTAR	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
WLSH3_k127_9958422_56	1305737.JAFX01000001_gene152	3.655e-05	56.0	COG2972@1|root,COG2972@2|Bacteria,4NF45@976|Bacteroidetes,47QDQ@768503|Cytophagia	976|Bacteroidetes	T	signal transduction protein with a C-terminal ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase,TPR_12,TPR_7,TPR_8
WLSH3_k127_9958422_38	688269.Theth_0659	1.159e-29	125.0	COG1670@1|root,COG1670@2|Bacteria,2GCZ2@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
WLSH3_k127_9958422_36	1121289.JHVL01000030_gene421	2.33e-30	124.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,36ESG@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
WLSH3_k127_9958422_51	1054217.TALC_00023	1.482e-10	70.0	COG1777@1|root,arCOG01684@2157|Archaea,2Y680@28890|Euryarchaeota,241VW@183967|Thermoplasmata	183967|Thermoplasmata	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
WLSH3_k127_9958422_39	646529.Desaci_0681	1.776e-29	125.0	COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes	1239|Firmicutes	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
WLSH3_k127_9958422_28	112098.XP_008608001.1	6.566e-41	166.0	28URR@1|root,2R1GQ@2759|Eukaryota	2759|Eukaryota	S	Domain of unknown function (DUF389)	-	GO:0007275,GO:0007399,GO:0008150,GO:0009987,GO:0022008,GO:0030154,GO:0032501,GO:0032502,GO:0048731,GO:0048856,GO:0048869	-	-	-	-	-	-	-	-	-	-	DUF389
WLSH3_k127_9958422_49	429009.Adeg_0217	4.491e-15	84.0	COG1280@1|root,COG1280@2|Bacteria,1V725@1239|Firmicutes,24KQ7@186801|Clostridia,42GHE@68295|Thermoanaerobacterales	186801|Clostridia	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
WLSH3_k127_9958422_29	1268239.PALB_27090	1.832e-39	154.0	COG2039@1|root,COG2039@2|Bacteria,1MWYG@1224|Proteobacteria,1RPYK@1236|Gammaproteobacteria,2Q0D7@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
WLSH3_k127_9958422_25	398512.JQKC01000014_gene1599	8.5e-45	175.0	COG0739@1|root,COG4870@1|root,COG0739@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185,GBS_Bsp-like,OapA,Peptidase_C1,Peptidase_M23
WLSH3_k127_9958422_12	374847.Kcr_0159	2.169e-97	333.0	COG0665@1|root,arCOG00755@2157|Archaea	2157|Archaea	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO
WLSH3_k127_9958422_40	1286171.EAL2_808p04730	7.438e-29	129.0	COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia,25VH3@186806|Eubacteriaceae	186801|Clostridia	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
WLSH3_k127_9958422_1	306281.AJLK01000030_gene1328	2.646e-170	548.0	COG1012@1|root,COG1012@2|Bacteria,1G09W@1117|Cyanobacteria,1JHZW@1189|Stigonemataceae	1117|Cyanobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
WLSH3_k127_9958422_27	374847.Kcr_0495	5.297e-42	158.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_IclR,TrmB
WLSH3_k127_9958422_7	439481.Aboo_0845	5.653e-106	353.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
WLSH3_k127_9958422_10	399550.Smar_1329	1.093e-98	331.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_9958422_23	1499967.BAYZ01000132_gene306	5.685e-55	220.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_9958422_19	1304874.JAFY01000002_gene135	2.882e-67	258.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_9958422_31	1184251.TCELL_1055	4.473e-33	147.0	COG0747@1|root,arCOG01534@2157|Archaea,2XQ84@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_9958422_5	273116.14324238	3.385e-110	373.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2421R@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WLSH3_k127_9958422_30	880073.Calab_1834	1.506e-38	157.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
WLSH3_k127_9958422_9	204669.Acid345_1532	1.057e-104	357.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria,2JKID@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
WLSH3_k127_9958422_16	43759.JNWK01000020_gene7372	2.181e-74	259.0	COG0388@1|root,COG0388@2|Bacteria,2GP6F@201174|Actinobacteria	201174|Actinobacteria	S	Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
WLSH3_k127_9958422_45	1196029.ALIM01000001_gene4950	5.736e-19	98.0	COG4927@1|root,COG4927@2|Bacteria,1TQGX@1239|Firmicutes,4HATV@91061|Bacilli,1ZC2P@1386|Bacillus	91061|Bacilli	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
WLSH3_k127_9958422_6	1118054.CAGW01000032_gene684	1.278e-109	374.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4HC54@91061|Bacilli,2758S@186822|Paenibacillaceae	91061|Bacilli	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
WLSH3_k127_9958422_43	997350.HMPREF9129_0943	5.238e-20	105.0	COG2234@1|root,COG2234@2|Bacteria,1TRWH@1239|Firmicutes,24BM1@186801|Clostridia	186801|Clostridia	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
WLSH3_k127_9958422_4	795797.C497_06439	2.826e-111	374.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,23ST7@183963|Halobacteria	183963|Halobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
WLSH3_k127_9958422_14	1265505.ATUG01000001_gene3442	4.727e-88	298.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
WLSH3_k127_9958422_8	1265505.ATUG01000001_gene3443	1.059e-105	352.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42Q6C@68525|delta/epsilon subdivisions,2WMD6@28221|Deltaproteobacteria,2MHY6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
WLSH3_k127_9958422_20	479434.Sthe_3281	1.995e-63	229.0	COG0726@1|root,COG0726@2|Bacteria,2GB8A@200795|Chloroflexi,27XZW@189775|Thermomicrobia	189775|Thermomicrobia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
WLSH3_k127_9958422_21	1198452.Jab_2c34270	6.803e-57	208.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4779T@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
WLSH3_k127_9958422_34	1476876.JOJO01000032_gene3856	5.966e-32	132.0	COG0500@1|root,COG2226@2|Bacteria,2GKPQ@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WLSH3_k127_9958422_11	925409.KI911562_gene2239	1.487e-97	329.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,1IPUF@117747|Sphingobacteriia	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
WLSH3_k127_9958422_57	421052.F945_00579	0.0002045	50.0	COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,1S5RX@1236|Gammaproteobacteria,3NNMQ@468|Moraxellaceae	1236|Gammaproteobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
WLSH3_k127_9958422_13	357808.RoseRS_3771	7.866e-93	324.0	COG2202@1|root,COG2203@1|root,COG3290@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3290@2|Bacteria,COG5002@2|Bacteria,2GBK6@200795|Chloroflexi,3770Y@32061|Chloroflexia	32061|Chloroflexia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HATPase_c,HisKA,PAS_9,Response_reg
WLSH3_k127_9958422_41	555079.Toce_0967	1.025e-28	125.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
WLSH3_k127_9958422_15	682795.AciX8_0803	1.915e-75	260.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
WLSH3_k127_9987300_68	666510.ASAC_0729	9.323e-12	74.0	arCOG03727@1|root,arCOG03727@2157|Archaea,2XRGX@28889|Crenarchaeota	28889|Crenarchaeota	L	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,NERD
WLSH3_k127_9987300_39	1459636.NTE_01385	2.408e-40	160.0	COG1650@1|root,arCOG01616@2157|Archaea,41SM3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
WLSH3_k127_9987300_55	413816.BBJP01000002_gene75	3.409e-18	90.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,23WBW@183963|Halobacteria	183963|Halobacteria	K	COG0456 Acetyltransferases	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_9987300_62	5693.XP_813967.1	3.386e-14	77.0	COG5133@1|root,KOG3381@2759|Eukaryota,3XV3D@5653|Kinetoplastida	5653|Kinetoplastida	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
WLSH3_k127_9987300_29	374847.Kcr_0737	3.154e-59	218.0	COG0476@1|root,arCOG01676@2157|Archaea	2157|Archaea	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	TBP,ThiF,ThiS
WLSH3_k127_9987300_56	748449.Halha_2283	7.911e-18	94.0	COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,3WAJ1@53433|Halanaerobiales	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
WLSH3_k127_9987300_16	511051.CSE_13400	5.594e-92	315.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WLSH3_k127_9987300_63	1307761.L21SP2_1765	1.936e-13	78.0	COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WLSH3_k127_9987300_65	694429.Pyrfu_1593	1.597e-12	68.0	COG3609@1|root,arCOG01009@2157|Archaea,2XR62@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
WLSH3_k127_9987300_0	370438.PTH_1507	8.701e-228	725.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,260BP@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
WLSH3_k127_9987300_30	760568.Desku_2302	1.36e-57	214.0	COG0857@1|root,COG0857@2|Bacteria,1UFKM@1239|Firmicutes,25M79@186801|Clostridia,260XJ@186807|Peptococcaceae	186801|Clostridia	C	DRTGG domain protein	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
WLSH3_k127_9987300_72	243231.GSU0217	5.75e-09	67.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
WLSH3_k127_9987300_83	999141.GME_15560	0.0005006	48.0	COG3255@1|root,COG3255@2|Bacteria,1N206@1224|Proteobacteria,1S8RI@1236|Gammaproteobacteria,1XKS6@135619|Oceanospirillales	135619|Oceanospirillales	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
WLSH3_k127_9987300_22	706587.Desti_2453	1.916e-71	255.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MQSA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
WLSH3_k127_9987300_32	195103.CPF_2585	7.816e-55	201.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
WLSH3_k127_9987300_13	1121430.JMLG01000002_gene1078	1.924e-99	338.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24FFI@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
WLSH3_k127_9987300_69	272557.APE_0930.1	1.357e-09	64.0	COG1545@1|root,arCOG01283@2157|Archaea,2XQEP@28889|Crenarchaeota	28889|Crenarchaeota	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
WLSH3_k127_9987300_64	314256.OG2516_00479	8.324e-13	82.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,2PDP4@252301|Oceanicola	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_9987300_75	1121456.ATVA01000011_gene1845	2.629e-06	61.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2M7XJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
WLSH3_k127_9987300_20	555088.DealDRAFT_3077	1.321e-73	259.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42JIV@68298|Syntrophomonadaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
WLSH3_k127_9987300_46	768706.Desor_0833	1.286e-34	144.0	COG0491@1|root,COG0491@2|Bacteria,1V62I@1239|Firmicutes,24I5E@186801|Clostridia,261TE@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_9987300_18	1382304.JNIL01000001_gene1376	8.71e-78	279.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4H9W6@91061|Bacilli	91061|Bacilli	G	Belongs to the FGGY kinase family	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
WLSH3_k127_9987300_14	448385.sce8683	1.438e-98	342.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42M8D@68525|delta/epsilon subdivisions,2WJ6E@28221|Deltaproteobacteria,2YWFY@29|Myxococcales	28221|Deltaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C,Fer2_BFD
WLSH3_k127_9987300_40	335543.Sfum_3498	4.44e-40	165.0	COG3075@1|root,COG3075@2|Bacteria,1MU3K@1224|Proteobacteria,42Q09@68525|delta/epsilon subdivisions,2WKE0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
WLSH3_k127_9987300_49	224719.Abm4_1340	8.679e-31	136.0	COG0479@1|root,arCOG00963@2157|Archaea,2Y85K@28890|Euryarchaeota,23PZE@183925|Methanobacteria	183925|Methanobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
WLSH3_k127_9987300_11	1499967.BAYZ01000050_gene2833	1.414e-104	357.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	2.5.1.26	ko:K00803,ko:K11472	ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146	-	R00475,R04311	RC00020,RC00042,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
WLSH3_k127_9987300_23	224325.AF_0506	1.788e-69	250.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
WLSH3_k127_9987300_24	796606.BMMGA3_15320	2.48e-66	240.0	COG2516@1|root,COG2516@2|Bacteria,1UI8Q@1239|Firmicutes,4HV1D@91061|Bacilli,1ZJTY@1386|Bacillus	91061|Bacilli	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WLSH3_k127_9987300_79	641491.DND132_0447	5.935e-05	52.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,2MCBQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
WLSH3_k127_9987300_34	224719.Abm4_0402	1.043e-51	203.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,23PG7@183925|Methanobacteria	183925|Methanobacteria	C	Belongs to the aldehyde dehydrogenase family	cofA	-	1.2.1.22	ko:K19266	ko00620,ko01120,map00620,map01120	-	R01446	RC00242	ko00000,ko00001,ko01000	-	-	-	Aldedh
WLSH3_k127_9987300_37	565033.GACE_0394	1.276e-43	175.0	COG0144@1|root,arCOG00974@2157|Archaea,2XSWG@28890|Euryarchaeota,245SS@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
WLSH3_k127_9987300_84	1236689.MMALV_07990	0.0005136	48.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,3F2TE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Belongs to the PDCD5 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
WLSH3_k127_9987300_38	665959.HMPREF1013_05654	7.856e-43	166.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,1ZB78@1386|Bacillus	91061|Bacilli	L	hydrolase, TatD	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WLSH3_k127_9987300_78	1236689.MMALV_13710	5.438e-05	54.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
WLSH3_k127_9987300_51	591019.Shell_1588	7.211e-23	109.0	COG2517@1|root,arCOG04359@2157|Archaea,2XR9E@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM t-RNA-binding domain protein	-	-	-	ko:K07135	-	-	-	-	ko00000	-	-	-	tRNA_bind
WLSH3_k127_9987300_70	313606.M23134_03740	2.676e-09	62.0	COG1694@1|root,COG1694@2|Bacteria,4NX1K@976|Bacteroidetes,47SM1@768503|Cytophagia	976|Bacteroidetes	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
WLSH3_k127_9987300_43	1379698.RBG1_1C00001G0785	6.115e-37	158.0	COG1541@1|root,COG1541@2|Bacteria,2NREC@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
WLSH3_k127_9987300_88	1459636.NTE_00576	0.000778	46.0	arCOG09752@1|root,arCOG09752@2157|Archaea,41T9M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WLSH3_k127_9987300_2	1042877.GQS_08425	5.479e-190	603.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
WLSH3_k127_9987300_76	368408.Tpen_0838	7.556e-06	53.0	COG2164@1|root,arCOG04488@2157|Archaea	2157|Archaea	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
WLSH3_k127_9987300_41	10224.XP_006816760.1	6.988e-38	157.0	28N5S@1|root,2QUR0@2759|Eukaryota,38D3V@33154|Opisthokonta,3CNNF@33208|Metazoa	33208|Metazoa	T	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
WLSH3_k127_9987300_73	1365176.N186_07805	8.153e-08	65.0	COG2159@1|root,arCOG01931@2157|Archaea	2157|Archaea	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	4.1.1.52	ko:K07045,ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
WLSH3_k127_9987300_81	349966.DJ58_1160	0.0001093	54.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,1RQPC@1236|Gammaproteobacteria,41DQA@629|Yersinia	1236|Gammaproteobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
WLSH3_k127_9987300_86	118166.JH976537_gene4459	0.0006387	51.0	COG1413@1|root,COG1413@2|Bacteria,1G2QG@1117|Cyanobacteria,1H7QX@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
WLSH3_k127_9987300_71	655815.ZPR_4397	4.675e-09	66.0	COG1266@1|root,COG1266@2|Bacteria,4NHRW@976|Bacteroidetes,1I1CE@117743|Flavobacteriia	976|Bacteroidetes	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WLSH3_k127_9987300_85	1089548.KI783301_gene1649	0.0005153	50.0	COG1585@1|root,COG1585@2|Bacteria,1VCUJ@1239|Firmicutes,4HPB4@91061|Bacilli	91061|Bacilli	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
WLSH3_k127_9987300_21	1163730.FFONT_0035	1.514e-71	251.0	COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
WLSH3_k127_9987300_47	351160.RCIX888	7.071e-34	142.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
WLSH3_k127_9987300_74	383372.Rcas_1802	1.657e-06	62.0	COG2170@1|root,COG2170@2|Bacteria,2G5NR@200795|Chloroflexi,375BI@32061|Chloroflexia	32061|Chloroflexia	F	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
WLSH3_k127_9987300_10	673860.AciM339_0160	5.354e-115	380.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
WLSH3_k127_9987300_8	1184251.TCELL_1162	2.244e-120	395.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
WLSH3_k127_9987300_25	1499967.BAYZ01000132_gene306	1.273e-63	238.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
WLSH3_k127_9987300_26	1499967.BAYZ01000132_gene305	3.423e-63	230.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WLSH3_k127_9987300_61	644966.Tmar_0685	1.345e-14	87.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,3WD2D@538999|Clostridiales incertae sedis	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_9987300_67	1235279.C772_01046	6.169e-12	79.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,26H18@186818|Planococcaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WLSH3_k127_9987300_44	1122939.ATUD01000020_gene2153	1.573e-36	152.0	COG2222@1|root,COG2222@2|Bacteria,2IN5A@201174|Actinobacteria,4CP71@84995|Rubrobacteria	84995|Rubrobacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
WLSH3_k127_9987300_54	244582.JQAK01000001_gene1737	1.094e-18	94.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,47F70@766|Rickettsiales	766|Rickettsiales	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
WLSH3_k127_9987300_58	1460634.JCM19037_4506	4.694e-16	87.0	COG0546@1|root,COG0546@2|Bacteria,1V1K2@1239|Firmicutes,4HGEI@91061|Bacilli	91061|Bacilli	K	haloacid dehalogenase-like hydrolase	-	-	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
WLSH3_k127_9987300_17	243232.MJ_0283	5.124e-80	275.0	COG0489@1|root,arCOG00585@2157|Archaea,2XTU2@28890|Euryarchaeota,23QCR@183939|Methanococci	183939|Methanococci	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
WLSH3_k127_9987300_50	1499967.BAYZ01000040_gene2241	7.83e-24	111.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	suhB	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
WLSH3_k127_9987300_82	27288.XP_003673477.1	0.000189	51.0	KOG2910@1|root,KOG2910@2759|Eukaryota,39TG5@33154|Opisthokonta,3P2SD@4751|Fungi,3QSDX@4890|Ascomycota,3RU69@4891|Saccharomycetes,3S14S@4893|Saccharomycetaceae	4751|Fungi	U	Belongs to the SNF7 family	VPS20	GO:0000815,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0006900,GO:0006996,GO:0007032,GO:0007034,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010008,GO:0010256,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0019538,GO:0019941,GO:0030163,GO:0031090,GO:0031410,GO:0031982,GO:0032509,GO:0032511,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036452,GO:0042221,GO:0042493,GO:0042886,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043328,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045324,GO:0046618,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0061024,GO:0070676,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1904669	-	ko:K12195	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	Snf7
WLSH3_k127_9987300_48	391623.TERMP_01217	3.278e-33	137.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
WLSH3_k127_9987300_9	479434.Sthe_0784	1.813e-117	389.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia	189775|Thermomicrobia	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WLSH3_k127_9987300_12	1123371.ATXH01000011_gene59	2.178e-104	352.0	COG1239@1|root,COG1239@2|Bacteria,2GH9I@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Magnesium chelatase, subunit ChlI	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase
WLSH3_k127_9987300_59	679926.Mpet_0638	1.349e-15	90.0	COG1239@1|root,COG1240@1|root,arCOG00438@2157|Archaea,arCOG06472@2157|Archaea,2XUP4@28890|Euryarchaeota,2N9BN@224756|Methanomicrobia	224756|Methanomicrobia	H	AAA domain (dynein-related subfamily)	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
WLSH3_k127_9987300_15	604354.TSIB_0767	5.538e-92	312.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
WLSH3_k127_9987300_35	1151117.AJLF01000001_gene1135	7.137e-47	178.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,2430B@183968|Thermococci	183968|Thermococci	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
WLSH3_k127_9987300_77	1132509.C447_02897	1.225e-05	51.0	arCOG02989@1|root,arCOG02989@2157|Archaea,2Y00B@28890|Euryarchaeota,23XHN@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1931
WLSH3_k127_9987300_28	999411.HMPREF1092_00708	1.336e-60	218.0	COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,36UH1@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
WLSH3_k127_9987300_60	933801.Ahos_1245	4.556e-15	87.0	COG0462@1|root,arCOG00067@2157|Archaea,2XQE3@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
WLSH3_k127_9987300_1	452637.Oter_0818	5.533e-195	617.0	COG0334@1|root,COG0334@2|Bacteria,46UBX@74201|Verrucomicrobia,3K7SK@414999|Opitutae	414999|Opitutae	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
WLSH3_k127_9987300_7	1123371.ATXH01000004_gene1732	2.533e-126	413.0	COG0115@1|root,COG0115@2|Bacteria,2GHRV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
WLSH3_k127_9987300_45	591019.Shell_0844	1.612e-36	144.0	COG0437@1|root,arCOG01500@2157|Archaea	2157|Archaea	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6
WLSH3_k127_9987300_5	574087.Acear_1487	6.563e-151	498.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
WLSH3_k127_9987300_52	1401067.HMPREF0872_08125	1.557e-20	97.0	COG1489@1|root,COG1833@1|root,COG1489@2|Bacteria,COG1833@2|Bacteria,1V1GZ@1239|Firmicutes,4H3QA@909932|Negativicutes	909932|Negativicutes	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	DUF123,SfsA
WLSH3_k127_9987300_42	339860.Msp_0617	2.502e-37	154.0	COG1365@1|root,arCOG00045@2157|Archaea,2XVQG@28890|Euryarchaeota,23NNR@183925|Methanobacteria	183925|Methanobacteria	S	PFAM ExsB family protein	-	-	-	ko:K07134	-	-	-	-	ko00000	-	-	-	-
WLSH3_k127_9987300_53	66377.JOBH01000008_gene6784	6.118e-19	98.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria	201174|Actinobacteria	S	Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WLSH3_k127_9987300_31	1041930.Mtc_0466	2.214e-55	212.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
WLSH3_k127_9987300_33	1131269.AQVV01000016_gene1859	3.277e-52	203.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
WLSH3_k127_9987300_27	1462527.CCDM010000001_gene2731	1.891e-62	229.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli	91061|Bacilli	E	succinyl-diaminopimelate desuccinylase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
WLSH3_k127_9987300_36	1227457.C451_06972	3.144e-44	169.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,23UTP@183963|Halobacteria	183963|Halobacteria	J	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
WLSH3_k127_9987300_19	386456.JQKN01000001_gene2066	9.029e-76	271.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
WLSH3_k127_9987300_80	374847.Kcr_0040	0.0001062	53.0	COG4901@1|root,arCOG04327@2157|Archaea	2157|Archaea	J	30S ribosomal protein S25E	rps25e	-	-	ko:K02975	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S25
WLSH3_k127_9987300_66	42099.EPrPV00000015006	2.514e-12	77.0	COG1100@1|root,KOG0070@2759|Eukaryota,1MB18@121069|Pythiales	121069|Pythiales	U	Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	Arf
WLSH3_k127_9987300_87	6211.A0A068XY72	0.0007758	53.0	KOG3341@1|root,KOG3341@2759|Eukaryota,38FCZ@33154|Opisthokonta,3B9KQ@33208|Metazoa,3CUGF@33213|Bilateria	33208|Metazoa	U	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs	SNF8	GO:0000003,GO:0000578,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031326,GO:0031410,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045921,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:1903506,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:2000112,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
WLSH3_k127_9987300_6	272844.PAB0323	9.647e-133	443.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
WLSH3_k127_9987300_3	868864.Dester_0096	1.085e-159	519.0	COG0146@1|root,COG0146@2|Bacteria,2G3NG@200783|Aquificae	200783|Aquificae	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
WLSH3_k127_9987300_4	1382306.JNIM01000001_gene2377	3.767e-152	505.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi	200795|Chloroflexi	EQ	Hydantoinaseoxoprolinase domain protein	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
## 2248 queries scanned
## Total time (seconds): 10.266669273376465
## Rate: 218.96 q/s