## Mon Nov 11 20:24:42 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/WX/WZS1_bin.21.fa -m mmseqs --itype genome -o WZS1_bin.21 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/WZS1_bin.21 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
WZS1_k127_1001985_0	158190.SpiGrapes_2070	4.304e-153	495.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
WZS1_k127_1001985_1	1480694.DC28_11565	2.76e-07	63.0	COG0797@1|root,COG0797@2|Bacteria	2|Bacteria	M	peptidoglycan binding	ydjM	-	-	-	-	-	-	-	-	-	-	-	DPBB_1,LysM,SPOR
WZS1_k127_101106_0	889378.Spiaf_2580	1.03e-211	667.0	COG0366@1|root,COG0366@2|Bacteria,2J6AH@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_101106_1	889378.Spiaf_2581	1.103e-158	512.0	COG0534@1|root,COG0534@2|Bacteria,2J6YG@203691|Spirochaetes	203691|Spirochaetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
WZS1_k127_101106_2	1480694.DC28_10110	3.958e-69	241.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
WZS1_k127_1022878_0	1313293.BAN_0078100	1.202e-29	118.0	COG0008@1|root,COG0008@2|Bacteria,2J5M7@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
WZS1_k127_1022878_1	889378.Spiaf_2575	2.41e-09	70.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,DLH,Esterase,Peptidase_S9
WZS1_k127_1023381_11	545694.TREPR_2679	6.593e-14	85.0	2FE8F@1|root,34689@2|Bacteria,2J592@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1023381_8	545695.TREAZ_0626	2.228e-19	90.0	2AMU2@1|root,31CQK@2|Bacteria,2J8GC@203691|Spirochaetes	203691|Spirochaetes	S	Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
WZS1_k127_1023381_0	744872.Spica_1424	1.059e-152	494.0	COG0305@1|root,COG0305@2|Bacteria,2J590@203691|Spirochaetes	203691|Spirochaetes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
WZS1_k127_1023381_5	573413.Spirs_2875	3.306e-39	151.0	COG0359@1|root,COG0359@2|Bacteria,2J6J9@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
WZS1_k127_1023381_6	545694.TREPR_2683	6.156e-25	107.0	COG0238@1|root,COG0238@2|Bacteria,2J8ZY@203691|Spirochaetes	203691|Spirochaetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
WZS1_k127_1023381_4	1125700.HMPREF9195_01977	8.132e-48	175.0	COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
WZS1_k127_1023381_9	573413.Spirs_2879	2.793e-19	90.0	COG0360@1|root,COG0360@2|Bacteria,2J88X@203691|Spirochaetes	203691|Spirochaetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
WZS1_k127_1023381_10	1480694.DC28_00875	6.381e-17	86.0	2B749@1|root,3205C@2|Bacteria,2J984@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1023381_7	1123274.KB899413_gene739	2.124e-23	110.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
WZS1_k127_1023381_2	59374.Fisuc_1107	6.387e-86	296.0	COG0837@1|root,COG0837@2|Bacteria	2|Bacteria	G	glucokinase activity	glk	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
WZS1_k127_1023381_1	889378.Spiaf_1277	4.337e-111	376.0	COG4284@1|root,COG4284@2|Bacteria,2J6J4@203691|Spirochaetes	203691|Spirochaetes	G	UTP--glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGP
WZS1_k127_1023381_3	1144310.PMI07_002127	6.731e-67	231.0	COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2VG87@28211|Alphaproteobacteria,4BNHK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
WZS1_k127_1023946_3	1307761.L21SP2_1843	1.449e-67	233.0	COG0104@1|root,COG0104@2|Bacteria,2J6B6@203691|Spirochaetes	203691|Spirochaetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
WZS1_k127_1023946_1	744872.Spica_1849	7.014e-222	698.0	COG0516@1|root,COG0516@2|Bacteria,2J5K7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
WZS1_k127_1023946_2	1123274.KB899424_gene3019	2.99e-177	567.0	COG0015@1|root,COG0015@2|Bacteria,2J60J@203691|Spirochaetes	203691|Spirochaetes	F	Adenylosuccinate lyase	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
WZS1_k127_1023946_5	243276.TPANIC_0095	7.009e-30	137.0	COG0457@1|root,COG0457@2|Bacteria,2J58A@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
WZS1_k127_1023946_4	1123274.KB899419_gene1998	6.658e-66	229.0	2C5UX@1|root,33TSC@2|Bacteria,2J5VA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1023946_0	573413.Spirs_2418	1.68e-309	972.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J6C2@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C
WZS1_k127_1023946_6	744872.Spica_1143	1.495e-06	49.0	2F0EQ@1|root,33THS@2|Bacteria,2J5ZQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1028791_0	398720.MED217_00275	4.405e-12	78.0	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,1HYP9@117743|Flavobacteriia,2XHWK@283735|Leeuwenhoekiella	976|Bacteroidetes	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
WZS1_k127_1031412_0	1237149.C900_01928	1.846e-234	747.0	COG3321@1|root,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,47XYI@768503|Cytophagia	976|Bacteroidetes	Q	PKS_KR	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_1033517_0	394503.Ccel_0862	3.168e-90	323.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_1036160_0	525897.Dbac_0704	2.48e-138	445.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2M8ZB@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_1036160_5	1227272.HMPREF1556_01914	0.0003462	48.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
WZS1_k127_1036160_4	240016.ABIZ01000001_gene2769	1.645e-31	132.0	COG4123@1|root,COG4123@2|Bacteria,46VM2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WZS1_k127_1036160_1	665571.STHERM_c02440	1.074e-102	345.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
WZS1_k127_1036160_3	665571.STHERM_c20830	2.911e-48	179.0	COG0494@1|root,COG0494@2|Bacteria,2J7P7@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
WZS1_k127_1036160_2	1123277.KB893195_gene5537	1.053e-69	252.0	COG4452@1|root,COG4452@2|Bacteria,4NGKY@976|Bacteroidetes,47NWS@768503|Cytophagia	976|Bacteroidetes	V	Inner membrane protein CreD	creD	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
WZS1_k127_104384_1	889378.Spiaf_0120	1.326e-135	451.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_104384_3	1002672.SAR11G3_00558	1.378e-07	54.0	2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_104384_0	889378.Spiaf_2354	3.884e-220	700.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	nolO	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
WZS1_k127_1059500_3	926556.Echvi_3308	2.807e-51	188.0	COG2996@1|root,COG2996@2|Bacteria,4NGS6@976|Bacteroidetes,47KDR@768503|Cytophagia	976|Bacteroidetes	S	S1 domain	yitL	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
WZS1_k127_1059500_1	1242864.D187_003809	2.512e-91	308.0	COG1091@1|root,COG1091@2|Bacteria,1NZK0@1224|Proteobacteria,43982@68525|delta/epsilon subdivisions,2X4F5@28221|Deltaproteobacteria,2YYWK@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
WZS1_k127_1059500_6	573413.Spirs_3158	8.493e-19	98.0	297T6@1|root,2ZUZW@2|Bacteria,2JB4N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1059500_2	1480694.DC28_03140	3.319e-84	293.0	COG2206@1|root,COG2206@2|Bacteria,2J6CD@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
WZS1_k127_1059500_4	573413.Spirs_3156	5.52e-42	165.0	2F691@1|root,33YSU@2|Bacteria,2J6FP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1059500_5	1123400.KB904757_gene2151	2.364e-37	144.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,460SW@72273|Thiotrichales	72273|Thiotrichales	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
WZS1_k127_1059500_0	1480694.DC28_03150	2.861e-150	479.0	COG0436@1|root,COG0436@2|Bacteria,2J5NJ@203691|Spirochaetes	203691|Spirochaetes	E	Aminotransferase class I and II	-	-	2.6.1.2,2.6.1.66	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	-	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_1065763_8	889378.Spiaf_2120	1.138e-59	208.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
WZS1_k127_1065763_3	1123274.KB899413_gene868	2.649e-104	351.0	COG0772@1|root,COG0772@2|Bacteria,2J58T@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
WZS1_k127_1065763_9	1125700.HMPREF9195_02342	4.242e-30	130.0	COG1589@1|root,COG1589@2|Bacteria,2J70E@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
WZS1_k127_1065763_1	573413.Spirs_1551	2.623e-119	396.0	COG0849@1|root,COG0849@2|Bacteria,2J5UK@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
WZS1_k127_1065763_2	1302858.I871_01590	7.676e-118	392.0	COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes	203691|Spirochaetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
WZS1_k127_1065763_4	1480694.DC28_02275	1.136e-82	285.0	COG4974@1|root,COG4974@2|Bacteria,2J7GT@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WZS1_k127_1065763_10	665571.STHERM_c09010	7.215e-20	98.0	COG0457@1|root,COG0457@2|Bacteria,2J7BD@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
WZS1_k127_1065763_7	1125700.HMPREF9195_01597	2.132e-60	221.0	COG0758@1|root,COG0758@2|Bacteria,2J6UM@203691|Spirochaetes	203691|Spirochaetes	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
WZS1_k127_1065763_6	744872.Spica_1676	8.811e-67	238.0	COG4974@1|root,COG4974@2|Bacteria,2J5UZ@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WZS1_k127_1065763_5	754027.HMPREF9554_00207	4.48e-76	258.0	COG5405@1|root,COG5405@2|Bacteria,2J608@203691|Spirochaetes	203691|Spirochaetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
WZS1_k127_1065763_0	889378.Spiaf_2109	1.908e-156	502.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
WZS1_k127_1073024_1	889378.Spiaf_2402	1.818e-23	103.0	COG4109@1|root,COG4109@2|Bacteria	2|Bacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
WZS1_k127_1073024_0	889378.Spiaf_2401	5.005e-108	357.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria,2J63A@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c
WZS1_k127_1073024_2	665571.STHERM_c13820	6.974e-21	96.0	COG4109@1|root,COG4109@2|Bacteria	2|Bacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
WZS1_k127_1073024_3	714943.Mucpa_0172	0.0002037	54.0	2CDGB@1|root,32SD8@2|Bacteria,4NU1M@976|Bacteroidetes,1J171@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1081288_1	1382305.AZUC01000054_gene2007	1.988e-80	280.0	COG4607@1|root,COG4607@2|Bacteria,1UXCZ@1239|Firmicutes,4HAMP@91061|Bacilli,26DQI@186818|Planococcaceae	91061|Bacilli	P	Periplasmic binding protein	yclQ	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	iYO844.BSU03830	Peripla_BP_2
WZS1_k127_1081288_0	1349767.GJA_3085	1.921e-87	296.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,4778N@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	PFAM short chain dehydrogenase	-	-	1.1.1.100,1.1.1.47,1.1.1.69,1.3.1.28	ko:K00034,ko:K00046,ko:K00059,ko:K00216	ko00030,ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01120,map01130,map01200,map01212	M00083,M00572	R01505,R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00066,RC00117,RC00534	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
WZS1_k127_1081288_2	1349767.GJA_3091	1.519e-15	77.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,473K1@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Linear gramicidin synthase subunit	-	-	6.3.2.14	ko:K02364	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
WZS1_k127_1106200_2	1265505.ATUG01000002_gene2419	1.206e-139	450.0	COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,42MMI@68525|delta/epsilon subdivisions,2WJZI@28221|Deltaproteobacteria,2MJBI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	molybdenum-iron protein alpha chain	nifD	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
WZS1_k127_1106200_12	177437.HRM2_09690	7.954e-49	179.0	COG0347@1|root,COG0347@2|Bacteria,1RKW3@1224|Proteobacteria,42SE6@68525|delta/epsilon subdivisions,2WP2V@28221|Deltaproteobacteria,2MK52@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K02590	-	-	-	-	ko00000	-	-	-	P-II
WZS1_k127_1106200_11	880072.Desac_0351	1.771e-54	193.0	COG0347@1|root,COG0347@2|Bacteria,1RIX2@1224|Proteobacteria,42SFQ@68525|delta/epsilon subdivisions,2WPG3@28221|Deltaproteobacteria,2MRTZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K02589	-	-	-	-	ko00000	-	-	-	P-II
WZS1_k127_1106200_1	573370.DMR_20560	1.066e-160	508.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,42NE5@68525|delta/epsilon subdivisions,2WJ14@28221|Deltaproteobacteria,2M97I@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
WZS1_k127_1106200_5	278963.ATWD01000001_gene2211	4.423e-100	333.0	COG1028@1|root,COG1028@2|Bacteria,3Y2JR@57723|Acidobacteria,2JJ3M@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
WZS1_k127_1106200_9	525898.Sdel_1372	1.018e-67	239.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2YMND@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
WZS1_k127_1106200_10	497964.CfE428DRAFT_6023	6.66e-56	209.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
WZS1_k127_1106200_7	1033737.CAEV01000077_gene682	9.915e-95	327.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
WZS1_k127_1106200_3	35754.JNYJ01000059_gene2231	4.791e-133	461.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4DBSI@85008|Micromonosporales	201174|Actinobacteria	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Ketoacyl-synt_C,Methyltransf_25,Nitroreductase,PP-binding,Thioesterase,ketoacyl-synt
WZS1_k127_1106200_13	179408.Osc7112_5180	7.706e-43	170.0	COG2175@1|root,COG2175@2|Bacteria,1G1VU@1117|Cyanobacteria,1H97U@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM Taurine catabolism dioxygenase TauD TfdA	-	-	-	-	-	-	-	-	-	-	-	-	TauD
WZS1_k127_1106200_4	41431.PCC8801_3028	1.112e-101	342.0	COG2175@1|root,COG2175@2|Bacteria,1G1VU@1117|Cyanobacteria,3KGG2@43988|Cyanothece	1117|Cyanobacteria	Q	PFAM Taurine catabolism dioxygenase TauD TfdA	-	-	-	-	-	-	-	-	-	-	-	-	TauD
WZS1_k127_1106200_8	744872.Spica_0068	2.342e-92	314.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.15,2.7.1.45	ko:K00852,ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01051,R01541,R02750	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
WZS1_k127_1106200_0	1316936.K678_03924	7.131e-215	679.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2TW04@28211|Alphaproteobacteria,2JYUS@204441|Rhodospirillales	204441|Rhodospirillales	KT	GAF domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Sigma54_activat
WZS1_k127_1106200_6	1121396.KB893046_gene3321	5.922e-96	326.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WJM0@28221|Deltaproteobacteria,2MJ63@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	nifV	-	2.3.3.13,2.3.3.14	ko:K01649,ko:K02594	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R00271,R01213	RC00004,RC00067,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
WZS1_k127_1106200_15	1167006.UWK_00343	6.121e-13	79.0	2EJZ1@1|root,33DPM@2|Bacteria,1QS6H@1224|Proteobacteria,42Y23@68525|delta/epsilon subdivisions,2WT02@28221|Deltaproteobacteria,2MMDU@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1106200_14	604331.AUHY01000028_gene1738	1.053e-41	162.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1WM1I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
WZS1_k127_1120116_0	1121904.ARBP01000009_gene4188	1.319e-229	716.0	COG0715@1|root,COG0715@2|Bacteria,4NGQ6@976|Bacteroidetes,47KV3@768503|Cytophagia	976|Bacteroidetes	P	NMT1-like family	-	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
WZS1_k127_1120116_1	1116472.MGMO_85c00200	4.291e-133	432.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,1RPP1@1236|Gammaproteobacteria,1XE8H@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
WZS1_k127_1120116_2	1116472.MGMO_85c00190	3.337e-71	244.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1XEX0@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM Nitrate transport ATP-binding	-	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
WZS1_k127_1124707_6	1507.HMPREF0262_01812	3.331e-05	46.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,36KHG@31979|Clostridiaceae	186801|Clostridia	T	Belongs to the UPF0237 family	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
WZS1_k127_1124707_0	203119.Cthe_0410	9.335e-220	691.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,3WGZM@541000|Ruminococcaceae	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
WZS1_k127_1124707_5	888060.HMPREF9081_0087	7.682e-06	55.0	COG2063@1|root,COG2063@2|Bacteria,1V4W8@1239|Firmicutes,4H4FZ@909932|Negativicutes	909932|Negativicutes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
WZS1_k127_1124707_1	665571.STHERM_c12200	1.523e-82	284.0	COG0324@1|root,COG0324@2|Bacteria,2J6T2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
WZS1_k127_1124707_3	744872.Spica_1185	3.226e-09	62.0	COG1933@1|root,COG1933@2|Bacteria,2J8VX@203691|Spirochaetes	203691|Spirochaetes	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
WZS1_k127_1124707_2	889378.Spiaf_1687	8.868e-34	134.0	COG2208@1|root,COG2208@2|Bacteria,2J5MN@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,SpoIIE
WZS1_k127_1129861_0	1307761.L21SP2_0899	4.177e-132	430.0	COG0202@1|root,COG0202@2|Bacteria,2J58K@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
WZS1_k127_1129861_1	158190.SpiGrapes_2160	8.352e-47	173.0	COG0203@1|root,COG0203@2|Bacteria,2J841@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
WZS1_k127_1129861_2	545695.TREAZ_2842	6.429e-30	136.0	COG3064@1|root,COG3064@2|Bacteria,2J6Q1@203691|Spirochaetes	203691|Spirochaetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_114226_0	317936.Nos7107_1366	0.0	1126.0	COG0515@1|root,COG0642@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	4.6.1.1	ko:K01768,ko:K07216	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,GAF,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_4,PAS_9,Pkinase,Response_reg
WZS1_k127_114226_2	1284352.AOIG01000010_gene1974	9.397e-145	468.0	28I4Y@1|root,2Z88D@2|Bacteria,1TY0K@1239|Firmicutes,4I73G@91061|Bacilli,26VXY@186822|Paenibacillaceae	91061|Bacilli	S	Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_114226_1	754027.HMPREF9554_02931	2.858e-169	540.0	COG4108@1|root,COG4108@2|Bacteria,2J9UA@203691|Spirochaetes	203691|Spirochaetes	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
WZS1_k127_1153622_0	744872.Spica_1257	3.021e-115	391.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
WZS1_k127_1153622_1	292414.TM1040_0702	1.544e-14	79.0	COG0834@1|root,COG0834@2|Bacteria,1N7XA@1224|Proteobacteria,2UG78@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
WZS1_k127_1205428_1	596324.TREVI0001_0007	6.823e-48	175.0	COG2402@1|root,COG2402@2|Bacteria,2JBJK@203691|Spirochaetes	203691|Spirochaetes	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
WZS1_k127_1205428_0	1480694.DC28_09955	4.774e-147	504.0	COG0612@1|root,COG0612@2|Bacteria,2J6UV@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the peptidase M16 family	pqqL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
WZS1_k127_121607_0	1123234.AUKI01000024_gene2118	1.087e-102	343.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,1HZJW@117743|Flavobacteriia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
WZS1_k127_121607_1	86416.Clopa_3997	1.237e-12	73.0	COG1621@1|root,COG1621@2|Bacteria,1VRC9@1239|Firmicutes,24XS0@186801|Clostridia,36QY1@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolases family 32 C terminal	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32C,Glyco_hydro_32N
WZS1_k127_1224492_4	266835.14026156	9.264e-20	93.0	COG2114@1|root,COG2114@2|Bacteria,1R51D@1224|Proteobacteria,2TT6W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
WZS1_k127_1224492_2	1295642.H839_16918	7.677e-36	141.0	COG1846@1|root,COG1846@2|Bacteria,1VA2C@1239|Firmicutes,4HMFU@91061|Bacilli	91061|Bacilli	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR,MarR_2
WZS1_k127_1224492_1	1121272.KB903292_gene4004	3.987e-115	387.0	COG5310@1|root,COG5310@2|Bacteria,2IRSZ@201174|Actinobacteria,4DHWP@85008|Micromonosporales	201174|Actinobacteria	Q	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
WZS1_k127_1224492_3	1307761.L21SP2_2224	4.613e-31	135.0	COG0223@1|root,COG0223@2|Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	-	GO:0003674,GO:0003824,GO:0004479,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0042802,GO:0042803,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044419,GO:0046483,GO:0046983,GO:0051704,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.2,2.1.2.9	ko:K00604,ko:K11175	ko00230,ko00670,ko00970,ko01100,ko01110,ko01130,map00230,map00670,map00970,map01100,map01110,map01130	M00048	R03940,R04325,R04326	RC00026,RC00165,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
WZS1_k127_1224492_0	1307761.L21SP2_2225	8.114e-133	444.0	COG2114@1|root,COG2114@2|Bacteria,2J6HA@203691|Spirochaetes	203691|Spirochaetes	T	Guanylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
WZS1_k127_1246882_0	1122225.AULQ01000002_gene639	5.04e-28	132.0	COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,4NF0G@976|Bacteroidetes,1I0VK@117743|Flavobacteriia	976|Bacteroidetes	M	RHS repeat-associated core domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN
WZS1_k127_1249449_3	485913.Krac_9942	5.125e-33	140.0	COG1011@1|root,COG1011@2|Bacteria,2G73G@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.102,3.1.3.104	ko:K07025,ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
WZS1_k127_1249449_1	1121335.Clst_1352	2.729e-127	415.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3WGJS@541000|Ruminococcaceae	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
WZS1_k127_1249449_0	665571.STHERM_c01070	1.7e-176	569.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
WZS1_k127_1249449_6	545695.TREAZ_3178	2.879e-06	61.0	2C0A1@1|root,33WBM@2|Bacteria,2J8WC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1249449_2	857293.CAAU_1774	5.185e-59	222.0	COG1752@1|root,COG1752@2|Bacteria,1UBYN@1239|Firmicutes,247V3@186801|Clostridia,36WRU@31979|Clostridiaceae	186801|Clostridia	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
WZS1_k127_1249449_5	1150626.PHAMO_490016	2.855e-10	64.0	COG4916@1|root,COG4916@2|Bacteria,1R81D@1224|Proteobacteria,2UBXF@28211|Alphaproteobacteria,2JXWC@204441|Rhodospirillales	204441|Rhodospirillales	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
WZS1_k127_1249449_4	1410676.JNKL01000004_gene704	4.086e-25	122.0	COG2206@1|root,COG3292@1|root,COG2206@2|Bacteria,COG3292@2|Bacteria,1RAQS@1224|Proteobacteria,1RRX6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	metal-dependent phosphohydrolase, HD	-	GO:0003674,GO:0003824,GO:0004112,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009187,GO:0009214,GO:0009987,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	HD,HD_5
WZS1_k127_1257320_3	573413.Spirs_3700	3.991e-77	268.0	COG1283@1|root,COG1283@2|Bacteria,2J64N@203691|Spirochaetes	203691|Spirochaetes	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
WZS1_k127_1257320_2	665571.STHERM_c17570	6.236e-98	331.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
WZS1_k127_1257320_0	744872.Spica_1486	9.915e-125	410.0	2EZ7M@1|root,33SDH@2|Bacteria,2J5HE@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1257320_4	665571.STHERM_c17580	9.822e-55	197.0	COG0778@1|root,COG0778@2|Bacteria,2J8VG@203691|Spirochaetes	203691|Spirochaetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
WZS1_k127_1257320_5	1307761.L21SP2_1594	7.465e-44	183.0	2AMR5@1|root,31CME@2|Bacteria,2J8JY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1257320_1	906968.Trebr_1206	9.497e-102	346.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
WZS1_k127_1257320_6	1123274.KB899406_gene1101	1.488e-29	126.0	COG2003@1|root,COG2003@2|Bacteria,2J7P5@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
WZS1_k127_1257320_9	565664.EFXG_00275	3.045e-11	69.0	COG1961@1|root,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,4HB3H@91061|Bacilli,4B6EG@81852|Enterococcaceae	91061|Bacilli	L	Recombinase zinc beta ribbon domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Ogr_Delta,Recombinase,Resolvase,Zn_ribbon_recom
WZS1_k127_1262876_4	573413.Spirs_4017	5.621e-114	374.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes	203691|Spirochaetes	C	Oxaloacetate decarboxylase, alpha subunit	oadA	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
WZS1_k127_1262876_1	1289135.A966_11212	5.267e-163	524.0	COG1883@1|root,COG1883@2|Bacteria,2J61F@203691|Spirochaetes	203691|Spirochaetes	C	Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
WZS1_k127_1262876_5	1480694.DC28_09995	3.481e-108	360.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
WZS1_k127_1262876_10	1480694.DC28_06775	7.723e-48	176.0	297PQ@1|root,2ZUWM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
WZS1_k127_1262876_12	889378.Spiaf_0105	1.81e-39	150.0	2DGCA@1|root,2ZVDU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1262876_11	889378.Spiaf_0106	1.21e-43	173.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1,sCache_2
WZS1_k127_1262876_2	1480694.DC28_06790	1.658e-141	475.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
WZS1_k127_1262876_8	744872.Spica_2854	4.757e-56	218.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
WZS1_k127_1262876_7	545695.TREAZ_2068	3.655e-77	285.0	COG1305@1|root,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
WZS1_k127_1262876_14	744872.Spica_2853	1.165e-09	70.0	29XQJ@1|root,30JG9@2|Bacteria,2J89K@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WZS1_k127_1262876_6	744872.Spica_2852	4.097e-98	329.0	COG0714@1|root,COG0714@2|Bacteria,2J5SG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WZS1_k127_1262876_3	744872.Spica_0062	4.835e-139	466.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,2JAHT@203691|Spirochaetes	203691|Spirochaetes	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
WZS1_k127_1262876_9	929556.Solca_0539	4.064e-54	198.0	COG1896@1|root,COG1896@2|Bacteria,4NGW7@976|Bacteroidetes,1IRIB@117747|Sphingobacteriia	976|Bacteroidetes	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
WZS1_k127_1262876_0	682795.AciX8_0658	3.874e-234	732.0	COG0362@1|root,COG0362@2|Bacteria,3Y3UI@57723|Acidobacteria,2JKMU@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
WZS1_k127_1262876_13	1307761.L21SP2_3220	3.757e-38	149.0	COG1047@1|root,COG1047@2|Bacteria,2J7P8@203691|Spirochaetes	203691|Spirochaetes	O	Peptidyl-prolyl cis-trans isomerase	-	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042026,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
WZS1_k127_1265408_3	906968.Trebr_2272	8.257e-62	214.0	COG0100@1|root,COG0100@2|Bacteria,2J7BP@203691|Spirochaetes	203691|Spirochaetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
WZS1_k127_1265408_4	744872.Spica_0407	2.488e-57	201.0	COG0099@1|root,COG0099@2|Bacteria,2J7QU@203691|Spirochaetes	203691|Spirochaetes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
WZS1_k127_1265408_8	411474.COPEUT_02181	1.632e-13	70.0	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
WZS1_k127_1265408_0	573413.Spirs_0975	2.719e-197	623.0	COG0201@1|root,COG0201@2|Bacteria,2J5BH@203691|Spirochaetes	203691|Spirochaetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
WZS1_k127_1265408_5	907348.TresaDRAFT_0678	5.605e-45	167.0	COG0200@1|root,COG0200@2|Bacteria,2J7ZW@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
WZS1_k127_1265408_7	665571.STHERM_c05140	1.234e-15	78.0	COG1841@1|root,COG1841@2|Bacteria,2J9BZ@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
WZS1_k127_1265408_2	1480694.DC28_14275	1.815e-66	230.0	COG0098@1|root,COG0098@2|Bacteria,2J60F@203691|Spirochaetes	203691|Spirochaetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
WZS1_k127_1265408_6	1353529.M899_3371	5.569e-32	128.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2MT98@213481|Bdellovibrionales,2WQ8U@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
WZS1_k127_1265408_1	1480694.DC28_14285	1.548e-70	242.0	COG0097@1|root,COG0097@2|Bacteria,2J7WB@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
WZS1_k127_1266673_0	4096.XP_009776361.1	2.72e-11	68.0	2E1M0@1|root,2S8XN@2759|Eukaryota,37WG5@33090|Viridiplantae,3GK4P@35493|Streptophyta	35493|Streptophyta	S	Plant mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PMD
WZS1_k127_1266977_5	1480694.DC28_08775	2.273e-71	249.0	COG1477@1|root,COG1477@2|Bacteria,2J5JH@203691|Spirochaetes	203691|Spirochaetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
WZS1_k127_1266977_6	1499967.BAYZ01000012_gene2457	8.367e-06	57.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
WZS1_k127_1266977_1	889378.Spiaf_2449	4.148e-135	436.0	COG0031@1|root,COG0031@2|Bacteria,2J5EE@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WZS1_k127_1266977_2	319225.Plut_1555	2.512e-127	416.0	COG1118@1|root,COG1118@2|Bacteria	2|Bacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015399,GO:0015405,GO:0015419,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:0099133,GO:1901265,GO:1901363,GO:1901682,GO:1902358	3.6.3.25,3.6.3.29	ko:K02017,ko:K02045,ko:K10112,ko:K16787	ko00920,ko02010,map00920,map02010	M00185,M00189,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00582,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.1,3.A.1.6.3,3.A.1.8	-	iE2348C_1286.E2348C_2607,iSSON_1240.SSON_2511	ABC_tran,TOBE,TOBE_3
WZS1_k127_1266977_4	315730.BcerKBAB4_1013	7.224e-103	342.0	COG4208@1|root,COG4208@2|Bacteria,1TS3N@1239|Firmicutes,4H9XE@91061|Bacilli,1ZB4T@1386|Bacillus	91061|Bacilli	P	COG4208 ABC-type sulfate transport system, permease component	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
WZS1_k127_1266977_3	319225.Plut_1553	1.757e-105	349.0	COG0555@1|root,COG0555@2|Bacteria	2|Bacteria	P	ATPase-coupled sulfate transmembrane transporter activity	cysT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02018,ko:K02046	ko00920,ko02010,map00920,map02010	M00185,M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.8	-	iJN746.PP_5170	BPD_transp_1
WZS1_k127_1266977_0	1450694.BTS2_1441	1.495e-144	465.0	COG1613@1|root,COG1613@2|Bacteria,1TS25@1239|Firmicutes,4HD5R@91061|Bacilli,1ZD34@1386|Bacillus	91061|Bacilli	P	COG1613 ABC-type sulfate transport system, periplasmic component	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
WZS1_k127_12757_0	744872.Spica_1667	2.237e-175	559.0	COG1157@1|root,COG1157@2|Bacteria,2J5IJ@203691|Spirochaetes	203691|Spirochaetes	NU	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
WZS1_k127_12757_1	1123274.KB899413_gene853	6.527e-50	180.0	COG1317@1|root,COG1317@2|Bacteria,2J5KZ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
WZS1_k127_1280332_0	665571.STHERM_c06640	6.741e-130	436.0	COG4254@1|root,COG4254@2|Bacteria,2J9KS@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
WZS1_k127_1280332_1	1480694.DC28_11085	1.149e-109	370.0	2EKDU@1|root,33E43@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1300926_1	1480694.DC28_00500	2.834e-59	207.0	COG0214@1|root,COG0214@2|Bacteria,2J5SI@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
WZS1_k127_1300926_2	545243.BAEV01000018_gene2184	1.29e-53	194.0	COG0311@1|root,COG0311@2|Bacteria,1V3I6@1239|Firmicutes,24HRT@186801|Clostridia,36I0R@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS19495	SNO
WZS1_k127_1300926_0	907348.TresaDRAFT_2409	6.834e-72	248.0	COG0563@1|root,COG0563@2|Bacteria,2J6MV@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
WZS1_k127_1300926_3	1423724.BAMM01000007_gene993	1.415e-08	57.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,4HNJ4@91061|Bacilli,3F811@33958|Lactobacillaceae	91061|Bacilli	T	Belongs to the UPF0237 family	XK27_08630	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
WZS1_k127_1311985_12	46429.BV95_01625	3.544e-37	151.0	COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,2U3JJ@28211|Alphaproteobacteria,2K248@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
WZS1_k127_1311985_11	1280664.AUIX01000007_gene3397	1.177e-42	171.0	COG3409@1|root,COG3409@2|Bacteria,1TSV8@1239|Firmicutes,24DXW@186801|Clostridia,4BXIB@830|Butyrivibrio	186801|Clostridia	M	spore coat polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1311985_4	545694.TREPR_0003	1.13e-142	466.0	COG1696@1|root,COG1696@2|Bacteria,2J6VT@203691|Spirochaetes	203691|Spirochaetes	M	membrane protein involved in D-alanine export	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
WZS1_k127_1311985_8	1239962.C943_01346	3.891e-74	262.0	2DX4H@1|root,32V2S@2|Bacteria,4NWQ8@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1311985_3	517417.Cpar_1802	1.026e-157	504.0	COG0451@1|root,COG0451@2|Bacteria,1FDWT@1090|Chlorobi	1090|Chlorobi	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
WZS1_k127_1311985_0	537970.HCAN_1262	1.785e-190	602.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2YMAG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
WZS1_k127_1311985_7	313624.NSP_50090	2.502e-77	272.0	COG0438@1|root,COG0438@2|Bacteria,1G27U@1117|Cyanobacteria,1HJI3@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WZS1_k127_1311985_1	545694.TREPR_2386	5.555e-171	540.0	COG0451@1|root,COG0451@2|Bacteria,2J7AZ@203691|Spirochaetes	203691|Spirochaetes	M	GDP-mannose 4,6 dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
WZS1_k127_1311985_14	391615.ABSJ01000007_gene656	2.72e-05	47.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1J5G5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	vipA	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
WZS1_k127_1311985_9	314230.DSM3645_11197	2.933e-63	227.0	COG0451@1|root,COG0451@2|Bacteria,2J4CD@203682|Planctomycetes	203682|Planctomycetes	M	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
WZS1_k127_1311985_10	1537915.JU57_07910	8.129e-50	183.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,430HP@68525|delta/epsilon subdivisions,2YS1K@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	dTDP_sugar_isom
WZS1_k127_1311985_5	312309.VF_0183	2.184e-132	433.0	COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,1RMKK@1236|Gammaproteobacteria,1XW6U@135623|Vibrionales	135623|Vibrionales	GM	Polysaccharide biosynthesis protein	-	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
WZS1_k127_1311985_6	1123371.ATXH01000036_gene1572	8.707e-126	406.0	COG1208@1|root,COG1208@2|Bacteria,2GHN7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
WZS1_k127_1311985_2	1293054.HSACCH_02456	1.166e-170	546.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	rfbH	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
WZS1_k127_1311985_13	1123274.KB899438_gene662	4.841e-09	61.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	-	-	1.14.12.17	ko:K02639,ko:K05916	ko00195,ko05132,map00195,map05132	-	-	-	ko00000,ko00001,ko00194,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
WZS1_k127_1312444_2	1307761.L21SP2_0473	6.541e-06	53.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_1312444_1	1411123.JQNH01000001_gene2362	1.542e-38	152.0	COG0664@1|root,COG0664@2|Bacteria,1Q93V@1224|Proteobacteria,2TTEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	cyclic nucleotide-binding	MA20_09210	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV,cNMP_binding
WZS1_k127_1312444_0	696281.Desru_0559	1.921e-79	279.0	COG0642@1|root,COG0642@2|Bacteria,1UZTI@1239|Firmicutes,24FQ6@186801|Clostridia,264AX@186807|Peptococcaceae	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
WZS1_k127_1339387_2	1480694.DC28_09135	1.079e-09	63.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,2J8XQ@203691|Spirochaetes	203691|Spirochaetes	T	Sigma factor PP2C-like phosphatases	spoIIE	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
WZS1_k127_1339387_1	1307761.L21SP2_0030	5.837e-25	112.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	yhgD	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K03577,ko:K09017	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_N
WZS1_k127_1339387_0	401053.AciPR4_2552	3.442e-134	443.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3Y3QY@57723|Acidobacteria,2JHPJ@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
WZS1_k127_13505_2	1128421.JAGA01000003_gene2953	1.574e-17	89.0	COG0366@1|root,COG0366@2|Bacteria,2NQQN@2323|unclassified Bacteria	2|Bacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
WZS1_k127_13505_1	404380.Gbem_1208	1.268e-28	120.0	COG1846@1|root,COG1846@2|Bacteria,1ND45@1224|Proteobacteria,42VCT@68525|delta/epsilon subdivisions,2WSSM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR
WZS1_k127_13505_0	794903.OPIT5_07185	1.123e-108	366.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,46V2T@74201|Verrucomicrobia,3K9RQ@414999|Opitutae	414999|Opitutae	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
WZS1_k127_1396253_0	1196323.ALKF01000138_gene3468	0.0	1670.0	COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_1412068_0	1321815.HMPREF9193_02196	1.077e-62	224.0	COG0845@1|root,COG0845@2|Bacteria,2J6XE@203691|Spirochaetes	203691|Spirochaetes	M	HlyD family secretion protein	-	-	-	ko:K20345	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	3.A.1.112,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3
WZS1_k127_1412068_1	243275.TDE_0427	3.606e-10	69.0	2BQ9F@1|root,32J49@2|Bacteria,2J871@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	OEP
WZS1_k127_1415501_2	665571.STHERM_c05940	4.706e-46	169.0	COG0787@1|root,COG0787@2|Bacteria,2J5JY@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
WZS1_k127_1415501_1	744872.Spica_2096	1.931e-113	374.0	COG1210@1|root,COG1210@2|Bacteria,2J70S@203691|Spirochaetes	203691|Spirochaetes	M	Nucleotidyl transferase	gtaB	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WZS1_k127_1415501_3	1123274.KB899410_gene3379	1.292e-14	83.0	295AQ@1|root,2ZSNW@2|Bacteria,2JB4R@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1415501_0	903818.KI912268_gene685	2.089e-229	723.0	COG3968@1|root,COG3968@2|Bacteria,3Y9EM@57723|Acidobacteria	57723|Acidobacteria	S	Glutamine synthetase type III N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GSIII_N,Gln-synt_C
WZS1_k127_1420679_2	1480694.DC28_00420	5.418e-12	66.0	COG1394@1|root,COG1394@2|Bacteria,2J59S@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
WZS1_k127_1420679_1	1480694.DC28_00425	1.558e-210	657.0	COG1156@1|root,COG1156@2|Bacteria,2J574@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
WZS1_k127_1420679_0	573413.Spirs_2459	3.901e-288	895.0	COG1155@1|root,COG1155@2|Bacteria,2J59J@203691|Spirochaetes	203691|Spirochaetes	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
WZS1_k127_1420679_3	545695.TREAZ_0099	7.52e-11	68.0	2EBXS@1|root,335X4@2|Bacteria,2J86W@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
WZS1_k127_1430120_4	1125699.HMPREF9194_01912	9.49e-30	122.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
WZS1_k127_1430120_2	1321781.HMPREF1985_01537	2.663e-93	314.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,4H1WJ@909932|Negativicutes	909932|Negativicutes	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
WZS1_k127_1430120_1	665571.STHERM_c19050	2.167e-95	322.0	COG4177@1|root,COG4177@2|Bacteria,2J5N5@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
WZS1_k127_1430120_0	906968.Trebr_2266	1.867e-121	396.0	COG0559@1|root,COG0559@2|Bacteria,2J64W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
WZS1_k127_1430120_3	545694.TREPR_1122	6.669e-33	130.0	COG0683@1|root,COG0683@2|Bacteria,2J62Q@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
WZS1_k127_1430865_1	744872.Spica_2768	2.936e-43	169.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365,ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
WZS1_k127_1430865_2	1121930.AQXG01000002_gene1988	6.897e-34	145.0	COG0739@1|root,COG0739@2|Bacteria,4NPNT@976|Bacteroidetes	976|Bacteroidetes	M	peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
WZS1_k127_1430865_0	1480694.DC28_12030	6.759e-94	317.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
WZS1_k127_1430865_3	1307761.L21SP2_3013	9.346e-20	93.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
WZS1_k127_1436008_2	1120983.KB894575_gene610	4.263e-61	220.0	COG2220@1|root,COG2220@2|Bacteria,1NNZA@1224|Proteobacteria,2U6PV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Beta-lactamase superfamily domain	-	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,Lactamase_B_2,Lactamase_B_3
WZS1_k127_1436008_4	313628.LNTAR_14082	2.762e-37	152.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	5.3.4.1	ko:K01829	-	-	-	-	ko00000,ko01000	-	-	-	Thioredoxin_7
WZS1_k127_1436008_3	1123274.KB899432_gene2937	5.73e-41	163.0	COG1196@1|root,COG1196@2|Bacteria,2J7QP@203691|Spirochaetes	203691|Spirochaetes	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
WZS1_k127_1436008_0	665571.STHERM_c00350	1.109e-113	377.0	COG0682@1|root,COG0682@2|Bacteria,2J58I@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
WZS1_k127_1436008_1	889378.Spiaf_2780	2.357e-68	243.0	COG1315@1|root,COG1315@2|Bacteria,2J5P2@203691|Spirochaetes	203691|Spirochaetes	L	PALM domain HD hydrolase domain and	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
WZS1_k127_1441832_0	1122915.AUGY01000014_gene2726	4.357e-133	437.0	COG3437@1|root,COG3437@2|Bacteria,1UYCB@1239|Firmicutes,4HE6S@91061|Bacilli,2769T@186822|Paenibacillaceae	91061|Bacilli	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,HD
WZS1_k127_1441832_3	1499967.BAYZ01000116_gene3146	4.008e-09	63.0	2EEHS@1|root,338BM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1441832_2	889378.Spiaf_1664	6.867e-54	194.0	COG0440@1|root,COG0440@2|Bacteria,2J7CQ@203691|Spirochaetes	203691|Spirochaetes	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
WZS1_k127_1441832_1	1307761.L21SP2_1902	2.61e-127	412.0	COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
WZS1_k127_1450878_2	1307761.L21SP2_2188	4.623e-156	500.0	COG2871@1|root,COG2871@2|Bacteria,2J8WH@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
WZS1_k127_1450878_6	1480694.DC28_05180	7.23e-88	293.0	COG2209@1|root,COG2209@2|Bacteria,2J9VZ@203691|Spirochaetes	203691|Spirochaetes	U	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
WZS1_k127_1450878_7	889378.Spiaf_1807	5.085e-81	276.0	COG1347@1|root,COG1347@2|Bacteria,2J9XJ@203691|Spirochaetes	203691|Spirochaetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
WZS1_k127_1450878_9	1307761.L21SP2_2185	3.242e-35	144.0	COG2869@1|root,COG2869@2|Bacteria,2JAPV@203691|Spirochaetes	203691|Spirochaetes	U	FMN_bind	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
WZS1_k127_1450878_5	889378.Spiaf_1805	2.187e-88	305.0	COG4658@1|root,COG4658@2|Bacteria	2|Bacteria	C	electron transport chain	-	-	1.6.5.8	ko:K00347,ko:K03614	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
WZS1_k127_1450878_8	1089553.Tph_c19490	1.198e-47	185.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,42ET4@68295|Thermoanaerobacterales	186801|Clostridia	H	biotin lipoate A B protein ligase	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
WZS1_k127_1450878_10	1499967.BAYZ01000075_gene2067	1.265e-31	128.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	ydaG	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx,Pyrid_ox_like
WZS1_k127_1450878_3	1499967.BAYZ01000075_gene2068	4.215e-128	416.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
WZS1_k127_1450878_1	1480694.DC28_05145	1.819e-160	511.0	COG0022@1|root,COG0022@2|Bacteria,2J9XH@203691|Spirochaetes	203691|Spirochaetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
WZS1_k127_1450878_4	1480694.DC28_05140	1.283e-127	420.0	COG0508@1|root,COG0508@2|Bacteria,2J9PH@203691|Spirochaetes	203691|Spirochaetes	C	component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
WZS1_k127_1450878_0	889378.Spiaf_1800	5.586e-195	617.0	COG1249@1|root,COG1249@2|Bacteria,2J7JJ@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
WZS1_k127_1462319_1	1173264.KI913949_gene2801	5.572e-40	153.0	COG0378@1|root,COG0378@2|Bacteria,1G0GT@1117|Cyanobacteria,1H9IV@1150|Oscillatoriales	1117|Cyanobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	iJN678.ureG	cobW
WZS1_k127_1462319_3	1123288.SOV_3c00930	3.496e-06	57.0	COG0829@1|root,COG0829@2|Bacteria,1TVM2@1239|Firmicutes,4H69I@909932|Negativicutes	909932|Negativicutes	O	UreD urease accessory protein	ureD	-	-	-	-	-	-	-	-	-	-	-	UreD
WZS1_k127_1462319_2	744872.Spica_2859	1.351e-24	109.0	COG1186@1|root,COG1186@2|Bacteria,2J8DU@203691|Spirochaetes	203691|Spirochaetes	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
WZS1_k127_1462319_0	671143.DAMO_1103	2.816e-112	374.0	COG0226@1|root,COG0226@2|Bacteria,2NQMD@2323|unclassified Bacteria	2|Bacteria	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
WZS1_k127_1467101_1	1307761.L21SP2_1798	4.184e-25	106.0	COG0036@1|root,COG0036@2|Bacteria,2J7B7@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
WZS1_k127_1467101_0	1123274.KB899421_gene1777	2.501e-52	196.0	COG1729@1|root,COG1729@2|Bacteria,2J5PP@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
WZS1_k127_1467101_2	744872.Spica_1369	3.801e-08	58.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cohesin,DUF11,SLH
WZS1_k127_1467737_1	439235.Dalk_3513	1.552e-90	328.0	COG2204@1|root,COG5000@1|root,COG5002@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MPMK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
WZS1_k127_1467737_2	1237149.C900_03648	1.91e-29	133.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,4NGZ0@976|Bacteroidetes	976|Bacteroidetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,Response_reg
WZS1_k127_1467737_3	555088.DealDRAFT_0328	2.731e-15	81.0	COG1846@1|root,COG1846@2|Bacteria,1VH12@1239|Firmicutes,24GYU@186801|Clostridia	186801|Clostridia	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR
WZS1_k127_1467737_0	573413.Spirs_1438	3.775e-138	455.0	COG0534@1|root,COG0534@2|Bacteria,2J6H0@203691|Spirochaetes	203691|Spirochaetes	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
WZS1_k127_1471166_0	889378.Spiaf_2748	7.068e-81	278.0	COG4866@1|root,COG4866@2|Bacteria,2J5HZ@203691|Spirochaetes	203691|Spirochaetes	S	conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
WZS1_k127_1471166_1	744872.Spica_1646	1.188e-53	191.0	COG3968@1|root,COG3968@2|Bacteria,2J5PV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
WZS1_k127_1476155_0	1196323.ALKF01000138_gene3468	3.947e-165	552.0	COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_1478625_0	322710.Avin_21190	7.867e-136	440.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	entF	-	-	ko:K15653	ko01053,map01053	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
WZS1_k127_1485271_0	1307761.L21SP2_0103	1.196e-138	461.0	COG0366@1|root,COG0366@2|Bacteria,2J6AH@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_1485271_4	1307761.L21SP2_2170	1.191e-26	127.0	COG0296@1|root,COG0296@2|Bacteria,2J6C4@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
WZS1_k127_1485271_1	889378.Spiaf_2352	1.981e-59	227.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,Lipase_GDSL_2
WZS1_k127_1485271_2	889378.Spiaf_2352	1.842e-54	212.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,Lipase_GDSL_2
WZS1_k127_1485271_5	869209.Tresu_2310	1.101e-10	64.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_1496652_4	1246474.ANBE01000057_gene2422	1.815e-65	231.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4EHDJ@85012|Streptosporangiales	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
WZS1_k127_1496652_3	1449063.JMLS01000003_gene2046	2.102e-86	294.0	COG3639@1|root,COG3639@2|Bacteria,1TQ73@1239|Firmicutes,4HD3S@91061|Bacilli,26WDR@186822|Paenibacillaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	phnE1	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
WZS1_k127_1496652_2	1121289.JHVL01000049_gene849	1.764e-87	296.0	COG3639@1|root,COG3639@2|Bacteria,1TR1S@1239|Firmicutes,24A7G@186801|Clostridia,36E1Q@31979|Clostridiaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	phnE_1	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
WZS1_k127_1496652_1	1121289.JHVL01000049_gene850	1.306e-107	353.0	COG3638@1|root,COG3638@2|Bacteria,1TQG6@1239|Firmicutes,249GS@186801|Clostridia,36GCJ@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
WZS1_k127_1496652_0	1449126.JQKL01000067_gene2130	4.741e-112	371.0	COG3221@1|root,COG3221@2|Bacteria,1U6JC@1239|Firmicutes,24D32@186801|Clostridia	186801|Clostridia	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
WZS1_k127_1496652_5	1211819.CALK01000014_gene387	2.827e-15	81.0	COG0483@1|root,COG0483@2|Bacteria,1TR4E@1239|Firmicutes,3VQZJ@526524|Erysipelotrichia	526524|Erysipelotrichia	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
WZS1_k127_1499202_0	744872.Spica_0922	2.263e-281	872.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
WZS1_k127_1499202_1	33898.JRHJ01000064_gene7599	9.621e-54	196.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
WZS1_k127_1512314_2	1196322.A370_05906	1.418e-170	554.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,36EC1@31979|Clostridiaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
WZS1_k127_1512314_1	889378.Spiaf_0155	9.344e-197	627.0	COG0366@1|root,COG0366@2|Bacteria,2J6FH@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_1512314_3	386456.JQKN01000001_gene2282	6.471e-62	218.0	COG0262@1|root,arCOG01490@2157|Archaea,2XZSN@28890|Euryarchaeota	28890|Euryarchaeota	H	Bifunctional deaminase-reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
WZS1_k127_1512314_0	350688.Clos_0054	1.627e-234	747.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WZS1_k127_1520802_1	1121024.AUCD01000034_gene1934	1.078e-142	479.0	COG1181@1|root,COG2918@1|root,COG1181@2|Bacteria,COG2918@2|Bacteria,1TPGX@1239|Firmicutes,4HAMJ@91061|Bacilli,27FSD@186828|Carnobacteriaceae	91061|Bacilli	HM	belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily	gshF	-	6.3.2.2	ko:K01919,ko:K16786,ko:K16787	ko00270,ko00480,ko01100,ko02010,map00270,map00480,map01100,map02010	M00118,M00582	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ATP-grasp_3,Dala_Dala_lig_C,GARS_A,Glu_cys_ligase
WZS1_k127_1520802_5	1123487.KB892857_gene2450	4.349e-21	95.0	2DPXU@1|root,333V1@2|Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
WZS1_k127_1520802_9	864051.BurJ1DRAFT_0027	0.0003976	51.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1MU3S@1224|Proteobacteria,2VZPE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	CARDB domain-containing protein,subtilase family protease	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
WZS1_k127_1520802_6	1123274.KB899408_gene3967	1.407e-12	77.0	2C5PF@1|root,2ZX2B@2|Bacteria,2J933@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1520802_2	313606.M23134_02417	9.728e-107	366.0	COG5316@1|root,COG5316@2|Bacteria,4NGER@976|Bacteroidetes,47MYA@768503|Cytophagia	976|Bacteroidetes	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
WZS1_k127_1520802_0	545695.TREAZ_3078	2.189e-203	653.0	COG0265@1|root,COG0265@2|Bacteria,2J6NJ@203691|Spirochaetes	203691|Spirochaetes	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
WZS1_k127_1520802_8	1536774.H70357_17390	1.878e-10	71.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
WZS1_k127_1520802_7	717606.PaecuDRAFT_0981	1.04e-10	72.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
WZS1_k127_1520802_3	926560.KE387025_gene4132	6.462e-88	296.0	COG2085@1|root,COG2085@2|Bacteria,1WMWM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored
WZS1_k127_153094_1	868131.MSWAN_0971	8.014e-87	294.0	COG0626@1|root,arCOG00060@2157|Archaea,2XT98@28890|Euryarchaeota,23PY0@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Cys Met metabolism, pyridoxal phosphate-dependent enzyme	-	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
WZS1_k127_153094_0	1410608.JNKX01000011_gene280	1.362e-113	377.0	COG0031@1|root,COG0031@2|Bacteria,4NDZ9@976|Bacteroidetes,2FME4@200643|Bacteroidia,4AKIV@815|Bacteroidaceae	976|Bacteroidetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WZS1_k127_153094_2	1303518.CCALI_00759	6.949e-53	204.0	COG0155@1|root,COG0155@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	1.7.7.1	ko:K00366	ko00910,ko01120,map00910,map01120	M00531	R00790	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
WZS1_k127_153431_1	573413.Spirs_3759	3.686e-18	87.0	COG1426@1|root,COG1426@2|Bacteria,2J61E@203691|Spirochaetes	203691|Spirochaetes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
WZS1_k127_153431_0	573413.Spirs_3757	1.869e-211	678.0	COG0210@1|root,COG0210@2|Bacteria,2J5EW@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
WZS1_k127_1577291_6	1123274.KB899424_gene3002	7.315e-65	235.0	COG0323@1|root,COG0323@2|Bacteria,2J5XE@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
WZS1_k127_1577291_2	1123274.KB899424_gene3003	1.338e-109	378.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
WZS1_k127_1577291_7	243275.TDE_1126	2.709e-21	104.0	COG0457@1|root,COG0457@2|Bacteria,2J7SI@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_7,TPR_8
WZS1_k127_1577291_0	573413.Spirs_2364	5.296e-154	499.0	COG0457@1|root,COG0457@2|Bacteria,2J5PC@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
WZS1_k127_1577291_4	573413.Spirs_2365	5.087e-83	281.0	COG2129@1|root,COG2129@2|Bacteria,2J5J9@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
WZS1_k127_1577291_3	1123274.KB899424_gene3007	1.155e-101	339.0	COG1475@1|root,COG1475@2|Bacteria,2J6CV@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1577291_1	1123008.KB905706_gene847	2.266e-119	391.0	COG0176@1|root,COG0176@2|Bacteria,4NFVZ@976|Bacteroidetes,2FNM3@200643|Bacteroidia,22YPA@171551|Porphyromonadaceae	976|Bacteroidetes	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
WZS1_k127_1577291_5	889378.Spiaf_2747	1.207e-68	239.0	COG2195@1|root,COG2195@2|Bacteria,2J59I@203691|Spirochaetes	203691|Spirochaetes	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
WZS1_k127_1580702_1	906968.Trebr_2083	2.06e-95	316.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
WZS1_k127_1580702_2	1480694.DC28_14920	7.028e-82	282.0	COG0812@1|root,COG0812@2|Bacteria,2J5SE@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
WZS1_k127_1580702_0	760011.Spico_0379	2.923e-183	584.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
WZS1_k127_1580702_3	744872.Spica_0667	1.266e-45	170.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
WZS1_k127_1580702_4	545695.TREAZ_0771	2.353e-07	59.0	COG5662@1|root,COG5662@2|Bacteria,2J8HF@203691|Spirochaetes	203691|Spirochaetes	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
WZS1_k127_1580702_5	545694.TREPR_1624	1.365e-05	53.0	2FF1T@1|root,34707@2|Bacteria,2J82I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1604514_0	889378.Spiaf_1472	1.104e-159	520.0	COG3605@1|root,COG3605@2|Bacteria,2JBCF@203691|Spirochaetes	203691|Spirochaetes	T	GAF domain	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
WZS1_k127_1604514_2	1307761.L21SP2_2104	3.626e-66	232.0	COG0220@1|root,COG0220@2|Bacteria,2J5YX@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
WZS1_k127_1604514_1	264732.Moth_1122	6.167e-118	385.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,42HUS@68295|Thermoanaerobacterales	186801|Clostridia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
WZS1_k127_1610534_0	1340493.JNIF01000003_gene2060	2.656e-50	202.0	COG0358@1|root,COG0358@2|Bacteria	2|Bacteria	L	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,Toprim_N,zf-CHC2
WZS1_k127_1615160_14	545695.TREAZ_1556	4.099e-21	93.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
WZS1_k127_1615160_9	243275.TDE_2185	2.053e-54	208.0	COG1653@1|root,COG1653@2|Bacteria,2J5NC@203691|Spirochaetes	203691|Spirochaetes	G	transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
WZS1_k127_1615160_3	545694.TREPR_3265	4.345e-129	425.0	COG0436@1|root,COG0436@2|Bacteria,2J5R0@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
WZS1_k127_1615160_2	1123274.KB899408_gene3912	2.149e-140	463.0	2EJFP@1|root,33D6N@2|Bacteria,2J5TW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
WZS1_k127_1615160_13	548477.HMPREF0294_0029	9.667e-26	115.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,22RBI@1653|Corynebacteriaceae	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567,ko:K07443	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
WZS1_k127_1615160_10	754436.JCM19237_3425	3.095e-46	179.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1XSY8@135623|Vibrionales	135623|Vibrionales	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
WZS1_k127_1615160_4	1307761.L21SP2_0221	3.553e-116	389.0	COG2262@1|root,COG2262@2|Bacteria,2J5R1@203691|Spirochaetes	203691|Spirochaetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
WZS1_k127_1615160_0	889378.Spiaf_0944	3.61e-202	653.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,DUF608,GDE_C
WZS1_k127_1615160_16	33178.CADATEAP00004742	3.112e-12	75.0	COG0666@1|root,KOG4177@2759|Eukaryota,39VF6@33154|Opisthokonta,3NZ3K@4751|Fungi,3QNR2@4890|Ascomycota,20DKP@147545|Eurotiomycetes	4751|Fungi	S	HET domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,HET,ZZ
WZS1_k127_1615160_15	796942.HMPREF9623_01107	1.66e-14	83.0	COG5018@1|root,COG5018@2|Bacteria,1TQJZ@1239|Firmicutes,24845@186801|Clostridia	186801|Clostridia	L	'dna polymerase iii	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
WZS1_k127_1615160_1	1123274.KB899429_gene2870	2.827e-145	469.0	COG0457@1|root,COG0457@2|Bacteria,2J5I5@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
WZS1_k127_1615160_12	573413.Spirs_3143	2.484e-26	111.0	291RI@1|root,2ZPBI@2|Bacteria,2J8IP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1615160_8	1480694.DC28_11895	3.531e-72	252.0	COG0131@1|root,COG0131@2|Bacteria,2J6ZQ@203691|Spirochaetes	203691|Spirochaetes	E	imidazoleglycerol-phosphate dehydratase	hisB	-	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_like,IGPD
WZS1_k127_1615160_6	1123274.KB899429_gene2867	1.994e-78	267.0	COG0040@1|root,COG0040@2|Bacteria,2J8TS@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
WZS1_k127_1615160_5	1123274.KB899429_gene2866	8.071e-84	291.0	COG3705@1|root,COG3705@2|Bacteria,2JB3U@203691|Spirochaetes	203691|Spirochaetes	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
WZS1_k127_1615160_7	889378.Spiaf_2061	5.58e-75	272.0	COG2206@1|root,COG2206@2|Bacteria,2JAC9@203691|Spirochaetes	203691|Spirochaetes	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1615160_11	646529.Desaci_1026	1.231e-33	142.0	COG1879@1|root,COG1879@2|Bacteria,1TQZS@1239|Firmicutes,25AZW@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
WZS1_k127_1615160_17	742735.HMPREF9467_04066	2.344e-11	73.0	COG2972@1|root,COG2972@2|Bacteria,1TSF9@1239|Firmicutes,2499Y@186801|Clostridia,21YMF@1506553|Lachnoclostridium	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
WZS1_k127_1628962_1	309801.trd_1791	1.718e-99	337.0	COG1092@1|root,COG1092@2|Bacteria,2G5YR@200795|Chloroflexi	200795|Chloroflexi	J	SMART PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
WZS1_k127_1628962_2	888060.HMPREF9081_0788	1.794e-09	64.0	COG0607@1|root,COG0607@2|Bacteria,1U5B4@1239|Firmicutes,4H7GW@909932|Negativicutes	909932|Negativicutes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
WZS1_k127_1628962_0	573413.Spirs_3660	1.42e-212	689.0	COG1026@1|root,COG1026@2|Bacteria,2J67R@203691|Spirochaetes	203691|Spirochaetes	S	peptidase, M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
WZS1_k127_1632027_3	760192.Halhy_1960	1.301e-06	50.0	COG2391@1|root,COG2391@2|Bacteria,4NM6E@976|Bacteroidetes,1IS2D@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM YeeE YedE family (DUF395)	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
WZS1_k127_1632027_0	1121373.KB903632_gene410	2.505e-28	120.0	COG2391@1|root,COG2391@2|Bacteria,4NQ9C@976|Bacteroidetes,47P92@768503|Cytophagia	976|Bacteroidetes	S	PFAM YeeE YedE family (DUF395)	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
WZS1_k127_1632027_2	243090.RB2839	3.794e-14	74.0	COG2996@1|root,COG2996@2|Bacteria,2J1Y7@203682|Planctomycetes	203682|Planctomycetes	S	S1 domain	-	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
WZS1_k127_1646105_0	3988.XP_002534772.1	1.148e-30	124.0	2CVN9@1|root,2S4GY@2759|Eukaryota,37WBG@33090|Viridiplantae,3GKIW@35493|Streptophyta,4JUZW@91835|fabids	35493|Streptophyta	P	ATP synthase subunit C	ATP9	GO:0000276,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02128	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_C
WZS1_k127_1656544_0	665571.STHERM_c02730	1.469e-134	449.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
WZS1_k127_1656544_3	545695.TREAZ_2059	7.752e-29	127.0	COG0454@1|root,COG0456@2|Bacteria,2J74W@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,UPF0158
WZS1_k127_1656544_1	744872.Spica_2540	4.022e-76	265.0	COG0204@1|root,COG0204@2|Bacteria,2J6GX@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
WZS1_k127_1656544_2	1480694.DC28_10150	9.486e-49	185.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
WZS1_k127_1703806_2	1480694.DC28_12245	1.783e-123	405.0	COG4586@1|root,COG4586@2|Bacteria,2J6K5@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_1703806_5	1480694.DC28_12240	3.644e-69	246.0	COG4587@1|root,COG4587@2|Bacteria	2|Bacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
WZS1_k127_1703806_4	1480694.DC28_12235	2.382e-78	275.0	COG3694@1|root,COG3694@2|Bacteria,2J7M7@203691|Spirochaetes	203691|Spirochaetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
WZS1_k127_1703806_6	573413.Spirs_0493	1.296e-47	189.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	Nuc_H_symport
WZS1_k127_1703806_3	586416.GZ22_17445	1.976e-86	300.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,4H9PE@91061|Bacilli	91061|Bacilli	E	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_1703806_1	1123274.KB899423_gene1611	2.55e-143	467.0	COG0426@1|root,COG0426@2|Bacteria,2J589@203691|Spirochaetes	203691|Spirochaetes	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5,Lactamase_B
WZS1_k127_1703806_0	1123274.KB899412_gene1535	1.401e-216	683.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
WZS1_k127_1707786_1	1307761.L21SP2_0016	1.05e-154	501.0	COG0046@1|root,COG0046@2|Bacteria,2J66J@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
WZS1_k127_1707786_2	744872.Spica_1837	5.592e-90	299.0	COG1592@1|root,COG1592@2|Bacteria,2J5MR@203691|Spirochaetes	203691|Spirochaetes	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WZS1_k127_1707786_5	1514668.JOOA01000001_gene511	7.294e-06	54.0	COG2247@1|root,COG2247@2|Bacteria,1U52U@1239|Firmicutes,259B6@186801|Clostridia,3WPVU@541000|Ruminococcaceae	186801|Clostridia	M	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1707786_0	247490.KSU1_C1668	2.743e-274	880.0	COG3696@1|root,COG3696@2|Bacteria,2IX94@203682|Planctomycetes	203682|Planctomycetes	P	AcrB/AcrD/AcrF family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
WZS1_k127_1707786_3	1379698.RBG1_1C00001G0079	2.651e-59	221.0	COG0845@1|root,COG0845@2|Bacteria,2NP3Y@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23,HlyD_D4
WZS1_k127_1707786_4	573413.Spirs_2761	1.432e-49	185.0	COG0745@1|root,COG0745@2|Bacteria,2J7YW@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulatory protein	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
WZS1_k127_1715505_0	1121335.Clst_1301	1.558e-66	243.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,3WG7U@541000|Ruminococcaceae	186801|Clostridia	G	Hydrolase Family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
WZS1_k127_1724751_0	1379698.RBG1_1C00001G0546	1.851e-75	264.0	COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
WZS1_k127_1724751_2	1121904.ARBP01000005_gene4613	3.091e-54	198.0	COG3201@1|root,COG3201@2|Bacteria,4NFJI@976|Bacteroidetes,47R6S@768503|Cytophagia	976|Bacteroidetes	H	TIGRFAM Nicotinamide mononucleotide transporter PnuC	pnuC	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
WZS1_k127_1724751_1	880071.Fleli_3886	4.057e-65	234.0	COG1056@1|root,COG3172@1|root,COG1056@2|Bacteria,COG3172@2|Bacteria,4NIFJ@976|Bacteroidetes,47XK6@768503|Cytophagia	976|Bacteroidetes	H	Citrate lyase ligase C-terminal domain	-	-	2.7.1.22,2.7.7.1	ko:K06211	ko00760,ko01100,map00760,map01100	-	R00137,R02324,R03005	RC00002,RC00017	ko00000,ko00001,ko01000,ko03000	-	-	-	AAA_28,Citrate_ly_lig
WZS1_k127_1724751_3	1121904.ARBP01000007_gene2929	1.026e-42	168.0	COG2340@1|root,COG2340@2|Bacteria,4NVRQ@976|Bacteroidetes,47SIP@768503|Cytophagia	976|Bacteroidetes	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
WZS1_k127_174495_0	1480694.DC28_14535	3.72e-224	704.0	COG0550@1|root,COG0550@2|Bacteria,2J5BS@203691|Spirochaetes	203691|Spirochaetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
WZS1_k127_174495_1	889378.Spiaf_1165	4.657e-62	241.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_177939_3	1123274.KB899428_gene1836	2.098e-72	251.0	COG0076@1|root,COG0076@2|Bacteria,2J6JJ@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
WZS1_k127_177939_1	573413.Spirs_1719	2.093e-127	420.0	COG0452@1|root,COG0452@2|Bacteria,2J5EB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
WZS1_k127_177939_4	1307761.L21SP2_1402	2.024e-67	235.0	COG2344@1|root,COG2344@2|Bacteria,2J67B@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
WZS1_k127_177939_6	1121918.ARWE01000001_gene655	1.827e-40	158.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.18.1.2,1.18.1.3,1.19.1.1	ko:K00528,ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513,R10159	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
WZS1_k127_177939_2	1353529.M899_2282	3.963e-119	389.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2MTIH@213481|Bdellovibrionales,2WIJQ@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
WZS1_k127_177939_7	521045.Kole_1621	2.89e-28	118.0	COG0509@1|root,COG0509@2|Bacteria,2GD57@200918|Thermotogae	200918|Thermotogae	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
WZS1_k127_177939_5	398767.Glov_2663	1.096e-58	214.0	COG0095@1|root,COG0095@2|Bacteria,1RI3T@1224|Proteobacteria,42SQP@68525|delta/epsilon subdivisions,2WQH2@28221|Deltaproteobacteria,43SNR@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Biotin/lipoate A/B protein ligase family	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
WZS1_k127_177939_0	889378.Spiaf_2048	5.465e-294	921.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41,3.2.1.68	ko:K01200,ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
WZS1_k127_178960_0	665571.STHERM_c02840	9.893e-79	271.0	COG2195@1|root,COG2195@2|Bacteria,2J59I@203691|Spirochaetes	203691|Spirochaetes	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
WZS1_k127_1789776_3	497964.CfE428DRAFT_6677	3.971e-70	244.0	COG2896@1|root,COG2896@2|Bacteria,46TG4@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Molybdenum Cofactor Synthesis C	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
WZS1_k127_1789776_4	1410666.JHXG01000003_gene1414	2.122e-58	215.0	COG0181@1|root,COG0373@1|root,COG0181@2|Bacteria,COG0373@2|Bacteria,4NFTY@976|Bacteroidetes,2FT24@200643|Bacteroidia	976|Bacteroidetes	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
WZS1_k127_1789776_7	269798.CHU_1321	8.632e-13	81.0	COG1773@1|root,COG1773@2|Bacteria,4NHF0@976|Bacteroidetes,47M86@768503|Cytophagia	976|Bacteroidetes	C	Rubredoxin	rubR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
WZS1_k127_1789776_0	153721.MYP_3887	0.0	1368.0	COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,4NG4N@976|Bacteroidetes,47JUR@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.7.2	ko:K00367	ko00910,ko01120,map00910,map01120	M00531	R00791	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,Pyr_redox_2
WZS1_k127_1789776_6	583355.Caka_1426	3.22e-34	134.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	nirD	-	1.7.1.15	ko:K00362,ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
WZS1_k127_1789776_1	313628.LNTAR_10551	1.324e-301	945.0	COG1251@1|root,COG1251@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nirB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0020037,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044464,GO:0045333,GO:0046857,GO:0046906,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051536,GO:0051540,GO:0055114,GO:0097159,GO:0098809,GO:1901265,GO:1901363	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3849	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2
WZS1_k127_1789776_2	1249997.JHZW01000002_gene1157	1.458e-108	358.0	COG1116@1|root,COG1116@2|Bacteria,4NE9U@976|Bacteroidetes,1I0MF@117743|Flavobacteriia,2PHYU@252356|Maribacter	976|Bacteroidetes	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049,ko:K15579	ko00910,ko02010,map00910,map02010	M00188,M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17	-	-	ABC_tran
WZS1_k127_1789776_5	1121904.ARBP01000009_gene4190	5.575e-37	143.0	COG1116@1|root,COG1116@2|Bacteria,4PKJ3@976|Bacteroidetes,47XCV@768503|Cytophagia	976|Bacteroidetes	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
WZS1_k127_17950_3	29760.VIT_04s0008g02170.t01	1.435e-05	50.0	COG0571@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG0701@2759|Eukaryota,37INP@33090|Viridiplantae,3GDT6@35493|Streptophyta	35493|Streptophyta	A	Belongs to the helicase family. Dicer subfamily	DCL3	GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0006139,GO:0006259,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009616,GO:0009892,GO:0009987,GO:0010033,GO:0010216,GO:0010267,GO:0010467,GO:0010468,GO:0010605,GO:0010608,GO:0010629,GO:0014070,GO:0016070,GO:0016246,GO:0016441,GO:0016442,GO:0016458,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019222,GO:0030422,GO:0031047,GO:0031050,GO:0031332,GO:0031974,GO:0031981,GO:0032296,GO:0032991,GO:0034641,GO:0035194,GO:0035821,GO:0040029,GO:0042221,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043331,GO:0044003,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045087,GO:0046483,GO:0048519,GO:0050789,GO:0050896,GO:0051214,GO:0051607,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0052018,GO:0052249,GO:0060255,GO:0065007,GO:0070013,GO:0070887,GO:0070918,GO:0071310,GO:0071359,GO:0071407,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0098542,GO:0098586,GO:0140098,GO:1901360,GO:1901363,GO:1901698,GO:1901699,GO:1990904	-	ko:K11592	ko05206,map05206	-	-	-	ko00000,ko00001,ko01000,ko03036	-	-	-	DEAD,Dicer_dimer,Helicase_C,PAZ,ResIII,Ribonuclease_3,dsrm
WZS1_k127_17950_2	4432.XP_010277171.1	1.664e-10	63.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RIF@33090|Viridiplantae	33090|Viridiplantae	O	Cysteine-rich RLK (RECEPTOR-like protein kinase) 8	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_3,Retrotrans_gag,gag_pre-integrs,rve
WZS1_k127_17950_0	29730.Gorai.001G165900.1	5.852e-150	475.0	COG0755@1|root,2QTE6@2759|Eukaryota,37Q3M@33090|Viridiplantae,3GHFY@35493|Streptophyta	35493|Streptophyta	O	cytochrome c biosynthesis ccmC-like mitochondrial	ccmC	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
WZS1_k127_17950_4	3750.XP_008347066.1	0.0002045	45.0	COG2801@1|root,KOG0017@2759|Eukaryota	3750.XP_008347066.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_185120_0	41431.PCC8801_1140	2.692e-45	181.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,3KH9M@43988|Cyanothece	1117|Cyanobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,Response_reg,dCache_1
WZS1_k127_1857419_0	1536772.R70723_17420	1.099e-313	1005.0	COG0366@1|root,COG1501@1|root,COG5434@1|root,COG0366@2|Bacteria,COG1501@2|Bacteria,COG5434@2|Bacteria,1V0U1@1239|Firmicutes,4HV3E@91061|Bacilli,26RZU@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-amylase	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
WZS1_k127_1857419_8	392499.Swit_1477	5.423e-16	91.0	COG2114@1|root,COG2203@1|root,COG5000@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG5000@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,2KCKE@204457|Sphingomonadales	204457|Sphingomonadales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
WZS1_k127_1857419_7	211165.AJLN01000072_gene5556	4.104e-31	138.0	COG2202@1|root,COG2203@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,1JK5I@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
WZS1_k127_1857419_1	889378.Spiaf_0609	4.977e-274	870.0	COG0004@1|root,COG0643@1|root,COG0004@2|Bacteria,COG0643@2|Bacteria,2JA63@203691|Spirochaetes	203691|Spirochaetes	NPT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,HATPase_c,Hpt
WZS1_k127_1857419_5	889378.Spiaf_0608	9.094e-53	190.0	COG1406@1|root,COG1406@2|Bacteria,2JAIP@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
WZS1_k127_1857419_6	889378.Spiaf_0607	6.99e-37	142.0	COG2201@1|root,COG2201@2|Bacteria,2JAI9@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
WZS1_k127_1857419_2	889378.Spiaf_0120	8.678e-130	438.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_1857419_3	414684.RC1_2755	4.042e-96	325.0	COG4111@1|root,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,2TQQU@28211|Alphaproteobacteria,2JQV4@204441|Rhodospirillales	204441|Rhodospirillales	F	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1857419_4	1120999.JONM01000001_gene1282	1.47e-73	259.0	COG0457@1|root,COG4676@1|root,COG0457@2|Bacteria,COG4676@2|Bacteria,1QZ6W@1224|Proteobacteria,2VKUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135,VIT
WZS1_k127_1861921_1	761193.Runsl_2200	5.71e-204	652.0	COG0514@1|root,COG0514@2|Bacteria,4NG10@976|Bacteroidetes,47JJ0@768503|Cytophagia	976|Bacteroidetes	L	ATP-dependent DNA helicase RecQ	recQ3	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
WZS1_k127_1861921_2	1415780.JPOG01000001_gene2341	1.547e-32	131.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,1S48Y@1236|Gammaproteobacteria,1X4PM@135614|Xanthomonadales	135614|Xanthomonadales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_1861921_4	314271.RB2654_05190	3.239e-16	83.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,2TW0V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_1861921_3	1415780.JPOG01000001_gene2342	2.961e-24	110.0	COG1309@1|root,COG1309@2|Bacteria,1N6FM@1224|Proteobacteria,1SZ1U@1236|Gammaproteobacteria,1XCWH@135614|Xanthomonadales	135614|Xanthomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
WZS1_k127_1861921_0	665571.STHERM_c15100	0.0	1048.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2J5NQ@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
WZS1_k127_1861921_5	329726.AM1_5397	7.165e-11	73.0	2C65N@1|root,33D51@2|Bacteria	2|Bacteria	S	Agenet domain	-	-	-	-	-	-	-	-	-	-	-	-	Agenet,Tudor-knot
WZS1_k127_1861921_6	203124.Tery_3459	6.695e-05	54.0	COG0823@1|root,COG3209@1|root,COG0823@2|Bacteria,COG3209@2|Bacteria,1GQZD@1117|Cyanobacteria	1117|Cyanobacteria	M	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1873204_3	1304874.JAFY01000002_gene78	5.46e-06	48.0	COG0346@1|root,COG0637@1|root,COG0346@2|Bacteria,COG0637@2|Bacteria,3TBVC@508458|Synergistetes	508458|Synergistetes	E	IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
WZS1_k127_1873204_0	665571.STHERM_c14270	1.848e-172	546.0	COG0180@1|root,COG0180@2|Bacteria,2J68U@203691|Spirochaetes	203691|Spirochaetes	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
WZS1_k127_1873204_2	555779.Dthio_PD2847	6.995e-25	112.0	COG3683@1|root,COG3683@2|Bacteria,1N8Q5@1224|Proteobacteria,42TQD@68525|delta/epsilon subdivisions,2WQFP@28221|Deltaproteobacteria,2MBQR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1007)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1007
WZS1_k127_1873204_1	1307761.L21SP2_0122	1.571e-111	373.0	COG1523@1|root,COG1523@2|Bacteria,2J58D@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,PUD
WZS1_k127_1877008_2	1307761.L21SP2_2226	8.741e-30	132.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08153,ko:K19576	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.10,2.A.1.2.8	-	-	MFS_1
WZS1_k127_1877008_0	1307761.L21SP2_2226	8.972e-146	499.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08153,ko:K19576	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.10,2.A.1.2.8	-	-	MFS_1
WZS1_k127_1877008_1	1288484.APCS01000125_gene482	7.381e-110	364.0	COG0502@1|root,COG0502@2|Bacteria,1WJVW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
WZS1_k127_1877008_3	1123252.ATZF01000001_gene1491	2.706e-17	86.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,27B1V@186824|Thermoactinomycetaceae	91061|Bacilli	H	Aminotransferase class-III	bioA	-	2.6.1.105,2.6.1.62	ko:K00833,ko:K19563	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231,R10699	RC00006,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS12705	Aminotran_3
WZS1_k127_1881639_6	1307761.L21SP2_3013	3.443e-15	79.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
WZS1_k127_1881639_2	1480694.DC28_13930	3.474e-63	219.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	yjbQ	-	-	-	-	-	-	-	-	-	-	-	UPF0047
WZS1_k127_1881639_4	744872.Spica_1005	4.471e-49	184.0	2C73B@1|root,330Z7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
WZS1_k127_1881639_1	1007103.AFHW01000160_gene3089	4.262e-75	266.0	COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,4H9PJ@91061|Bacilli,26R2G@186822|Paenibacillaceae	91061|Bacilli	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA_2	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
WZS1_k127_1881639_3	189426.PODO_19265	1.626e-62	218.0	28NIH@1|root,2ZBJX@2|Bacteria,1V1SN@1239|Firmicutes,4HFXW@91061|Bacilli,2752Y@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1881639_0	1121438.JNJA01000020_gene2747	1.382e-76	277.0	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,42Y97@68525|delta/epsilon subdivisions,2WTJS@28221|Deltaproteobacteria,2MAZV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,dCache_1
WZS1_k127_1881639_5	1124982.MSI_05170	1.987e-22	98.0	COG3668@1|root,COG3668@2|Bacteria,2J9DR@203691|Spirochaetes	203691|Spirochaetes	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
WZS1_k127_1882371_1	889378.Spiaf_1862	3.71e-57	218.0	COG0760@1|root,COG0760@2|Bacteria,2J720@203691|Spirochaetes	203691|Spirochaetes	O	PFAM PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,SurA_N_2,SurA_N_3
WZS1_k127_1882371_2	754027.HMPREF9554_02613	4.113e-53	207.0	COG2604@1|root,COG2604@2|Bacteria,2J5F2@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
WZS1_k127_1882371_0	744872.Spica_0806	2.176e-281	876.0	COG0481@1|root,COG0481@2|Bacteria,2J5V8@203691|Spirochaetes	203691|Spirochaetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
WZS1_k127_1882371_3	521674.Plim_2329	3.848e-22	107.0	COG2172@1|root,COG2197@1|root,COG2172@2|Bacteria,COG2197@2|Bacteria,2IYG7@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,Response_reg
WZS1_k127_1882371_4	1307761.L21SP2_1453	2.388e-05	49.0	COG0265@1|root,COG0265@2|Bacteria,2J5SD@203691|Spirochaetes	203691|Spirochaetes	O	Trypsin domain PDZ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WZS1_k127_1891940_1	665571.STHERM_c18920	2.946e-24	106.0	COG0741@1|root,COG0741@2|Bacteria,2J7TT@203691|Spirochaetes	203691|Spirochaetes	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
WZS1_k127_1891940_0	665571.STHERM_c18910	2.801e-102	351.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
WZS1_k127_1891940_2	545695.TREAZ_3210	1.03e-12	73.0	2EW9N@1|root,33PNA@2|Bacteria,2J5CY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1919683_1	319225.Plut_1185	0.0002708	49.0	COG3876@1|root,COG3876@2|Bacteria,1FDF0@1090|Chlorobi	1090|Chlorobi	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
WZS1_k127_1919683_0	1158338.JNLJ01000001_gene325	1.972e-276	864.0	COG1048@1|root,COG1048@2|Bacteria,2G3S7@200783|Aquificae	200783|Aquificae	C	TIGRFAM aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
WZS1_k127_1926914_2	402777.KB235903_gene1112	9.092e-74	263.0	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	2|Bacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase
WZS1_k127_1926914_6	1307761.L21SP2_2606	8.425e-30	123.0	COG0745@1|root,COG0745@2|Bacteria	1307761.L21SP2_2606|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1926914_7	744872.Spica_0689	1.118e-21	97.0	COG0011@1|root,COG0011@2|Bacteria,2J97E@203691|Spirochaetes	203691|Spirochaetes	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
WZS1_k127_1926914_3	102129.Lepto7375DRAFT_7693	5.207e-53	189.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
WZS1_k127_1926914_5	56110.Oscil6304_4986	7.19e-31	129.0	COG0727@1|root,COG0727@2|Bacteria,1G77E@1117|Cyanobacteria,1HBRF@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
WZS1_k127_1926914_1	889378.Spiaf_2052	1.29e-150	484.0	COG0722@1|root,COG0722@2|Bacteria,2J6I9@203691|Spirochaetes	203691|Spirochaetes	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
WZS1_k127_1926914_4	1304885.AUEY01000016_gene3063	2.408e-46	173.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2WMK3@28221|Deltaproteobacteria,2MJT8@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
WZS1_k127_1926914_0	1042375.AFPL01000055_gene2238	5.312e-245	782.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,465DP@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	aminopeptidase N	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042	DUF3458,DUF3458_C,Peptidase_M1
WZS1_k127_1926914_8	1033732.CAHI01000035_gene2516	8.979e-05	50.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FM4Z@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF5110,Glyco_hydro_31
WZS1_k127_1939076_1	545695.TREAZ_2351	1.665e-289	910.0	COG0188@1|root,COG0188@2|Bacteria,2J5NK@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
WZS1_k127_1939076_0	573413.Spirs_4306	1.84e-294	916.0	COG0187@1|root,COG0187@2|Bacteria,2J67M@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
WZS1_k127_1939076_3	1123274.KB899423_gene1593	4.167e-144	470.0	COG0593@1|root,COG0593@2|Bacteria,2J5F6@203691|Spirochaetes	203691|Spirochaetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
WZS1_k127_1939076_4	573413.Spirs_0003	2.433e-142	460.0	COG0592@1|root,COG0592@2|Bacteria,2J629@203691|Spirochaetes	203691|Spirochaetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
WZS1_k127_1939076_10	1123274.KB899423_gene1595	3.912e-99	336.0	COG1195@1|root,COG1195@2|Bacteria,2J5MP@203691|Spirochaetes	203691|Spirochaetes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
WZS1_k127_1939076_18	545694.TREPR_0273	9.873e-16	82.0	COG5512@1|root,COG5512@2|Bacteria,2J8RK@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
WZS1_k127_1939076_19	349124.Hhal_1228	1.583e-12	68.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1WZNE@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
WZS1_k127_1939076_17	1123274.KB899423_gene1598	8.855e-23	103.0	COG0594@1|root,COG0594@2|Bacteria,2J8R6@203691|Spirochaetes	203691|Spirochaetes	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
WZS1_k127_1939076_16	324057.Pjdr2_2272	6.118e-27	112.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,4HPA3@91061|Bacilli,26Z59@186822|Paenibacillaceae	91061|Bacilli	S	Could be involved in insertion of integral membrane proteins into the membrane	ytjA	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
WZS1_k127_1939076_8	1123274.KB899423_gene1599	3.219e-121	410.0	COG0706@1|root,COG0706@2|Bacteria,2J5HA@203691|Spirochaetes	203691|Spirochaetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
WZS1_k127_1939076_11	1125725.HMPREF1325_2197	3.273e-60	215.0	COG1847@1|root,COG1847@2|Bacteria,2J5S0@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
WZS1_k127_1939076_15	573413.Spirs_4277	3.187e-32	132.0	COG1846@1|root,COG1846@2|Bacteria,2J8XK@203691|Spirochaetes	203691|Spirochaetes	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
WZS1_k127_1939076_2	709032.Sulku_2135	3.041e-204	643.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2YMID@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
WZS1_k127_1939076_14	889378.Spiaf_1759	1.688e-42	168.0	COG1262@1|root,COG5492@1|root,COG1262@2|Bacteria,COG5492@2|Bacteria,2J6K7@203691|Spirochaetes	203691|Spirochaetes	N	hmm pf03781	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,FGE-sulfatase
WZS1_k127_1939076_6	1480694.DC28_12785	1.603e-134	434.0	COG1209@1|root,COG1209@2|Bacteria,2J5YM@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WZS1_k127_1939076_12	1480694.DC28_12780	3.995e-57	206.0	COG1898@1|root,COG1898@2|Bacteria,2J65Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
WZS1_k127_1939076_5	1480694.DC28_12770	2.034e-141	459.0	COG1088@1|root,COG1088@2|Bacteria,2J5ND@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
WZS1_k127_1939076_9	555779.Dthio_PD1581	3.788e-107	362.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,42MJF@68525|delta/epsilon subdivisions,2WJYR@28221|Deltaproteobacteria,2M9NA@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glycos_transf_1
WZS1_k127_1939076_13	1226325.HMPREF1548_07013	1.982e-56	212.0	COG0438@1|root,COG0438@2|Bacteria,1V1BU@1239|Firmicutes,24E05@186801|Clostridia,36VGN@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	2.4.1.291	ko:K17248	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
WZS1_k127_1939076_7	744872.Spica_1456	4.695e-134	445.0	COG1132@1|root,COG1132@2|Bacteria,2J5VU@203691|Spirochaetes	203691|Spirochaetes	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
WZS1_k127_1953666_0	72658.Bostr.10323s0001.1.p	3.086e-56	199.0	2EAH3@1|root,2SGQW@2759|Eukaryota,37XMR@33090|Viridiplantae,3GMSK@35493|Streptophyta	35493|Streptophyta	S	BEST Arabidopsis thaliana protein match is	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1978599_0	1123274.KB899421_gene1771	1.35e-146	481.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
WZS1_k127_1978599_1	1123274.KB899421_gene1770	5.23e-30	134.0	COG2304@1|root,COG2304@2|Bacteria,2J67D@203691|Spirochaetes	203691|Spirochaetes	K	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
WZS1_k127_1978857_11	3659.XP_004149312.1	1.807e-07	55.0	COG2801@1|root,KOG0017@2759|Eukaryota,388W5@33090|Viridiplantae,3GXMS@35493|Streptophyta	35493|Streptophyta	L	transposition, RNA-mediated	-	-	4.2.3.75	ko:K15803	ko00909,map00909	-	R07648	RC02425	ko00000,ko00001,ko01000	-	-	-	Retrotrans_gag,Terpene_synth_C
WZS1_k127_1978857_6	3885.XP_007149658.1	2.6e-22	100.0	2D60P@1|root,2T0AR@2759|Eukaryota,3832B@33090|Viridiplantae,3GS3D@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1978857_2	3659.XP_004149312.1	2.965e-51	182.0	COG2801@1|root,KOG0017@2759|Eukaryota,388W5@33090|Viridiplantae,3GXMS@35493|Streptophyta	35493|Streptophyta	L	transposition, RNA-mediated	-	-	4.2.3.75	ko:K15803	ko00909,map00909	-	R07648	RC02425	ko00000,ko00001,ko01000	-	-	-	Retrotrans_gag,Terpene_synth_C
WZS1_k127_1978857_0	3649.evm.model.supercontig_900.3	1.203e-254	786.0	COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta,3HYCY@3699|Brassicales	35493|Streptophyta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	-	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
WZS1_k127_1978857_12	3988.XP_002535305.1	0.000307	45.0	2ES36@1|root,2SURG@2759|Eukaryota,381I4@33090|Viridiplantae,3GQIR@35493|Streptophyta,4JVFZ@91835|fabids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1978857_4	29730.Gorai.001G163400.1	4.926e-43	158.0	COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta	35493|Streptophyta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	nad5	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M,Proton_antipo_N
WZS1_k127_1978857_7	3988.XP_002535305.1	8.566e-17	81.0	2ES36@1|root,2SURG@2759|Eukaryota,381I4@33090|Viridiplantae,3GQIR@35493|Streptophyta,4JVFZ@91835|fabids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_1978857_3	3880.AES58563	8.197e-48	171.0	COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta	35493|Streptophyta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	nad5	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M,Proton_antipo_N
WZS1_k127_1978857_8	3694.POPTR_0014s19210.1	3.019e-13	70.0	28MAV@1|root,2QTU9@2759|Eukaryota,37TGW@33090|Viridiplantae,3GFX6@35493|Streptophyta,4JS8H@91835|fabids	35493|Streptophyta	S	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
WZS1_k127_1978857_1	13333.ERN11400	1.579e-111	362.0	28ISP@1|root,2QR3X@2759|Eukaryota,37T53@33090|Viridiplantae,3G7SE@35493|Streptophyta	35493|Streptophyta	C	One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation	psbC	-	-	ko:K02705	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	PSII
WZS1_k127_1997538_4	1123248.KB893326_gene1377	4.773e-47	183.0	COG1409@1|root,COG1409@2|Bacteria,4NEUD@976|Bacteroidetes,1IZQN@117747|Sphingobacteriia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
WZS1_k127_1997538_2	665571.STHERM_c22100	3.172e-75	267.0	COG2843@1|root,COG2843@2|Bacteria,2J6GA@203691|Spirochaetes	203691|Spirochaetes	M	Bacterial capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
WZS1_k127_1997538_5	869209.Tresu_0357	3.305e-34	139.0	COG1739@1|root,COG1739@2|Bacteria,2J7AS@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0029, Impact, N-terminal	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF1949,UPF0029
WZS1_k127_1997538_0	629265.PMA4326_28252	3.028e-183	580.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,1Z536@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speC	-	4.1.1.17,4.1.1.20	ko:K01581,ko:K01586	ko00300,ko00330,ko00480,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map00480,map01100,map01110,map01120,map01130,map01230	M00016,M00134,M00525,M00526,M00527	R00451,R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0864	Orn_Arg_deC_N,Orn_DAP_Arg_deC
WZS1_k127_1997538_3	926561.KB900617_gene2286	1.323e-70	254.0	COG2182@1|root,COG2182@2|Bacteria,1TPU9@1239|Firmicutes,247KG@186801|Clostridia,3WAB7@53433|Halanaerobiales	186801|Clostridia	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
WZS1_k127_1997538_1	56107.Cylst_4282	9.842e-78	284.0	COG0642@1|root,COG4191@1|root,COG5000@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1G13T@1117|Cyanobacteria,1HTV7@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Response_reg,dCache_1
WZS1_k127_200270_0	906968.Trebr_2201	0.0	1085.0	COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes	203691|Spirochaetes	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
WZS1_k127_200270_4	665571.STHERM_c20920	6.451e-19	90.0	COG4802@1|root,COG4802@2|Bacteria	2|Bacteria	C	ferredoxin-thioredoxin reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B,Rhodanese
WZS1_k127_200270_5	889378.Spiaf_0364	3.13e-14	77.0	COG0695@1|root,COG0695@2|Bacteria,2JB4B@203691|Spirochaetes	203691|Spirochaetes	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
WZS1_k127_200270_1	909663.KI867150_gene1123	1.745e-63	230.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,42UVY@68525|delta/epsilon subdivisions,2WR44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
WZS1_k127_200270_3	1353529.M899_3007	2.934e-31	127.0	COG1832@1|root,COG1832@2|Bacteria,1PUW7@1224|Proteobacteria,42T5D@68525|delta/epsilon subdivisions,2WPHZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
WZS1_k127_200270_2	1408422.JHYF01000002_gene2247	7.775e-46	169.0	COG0569@1|root,COG0569@2|Bacteria,1TSR4@1239|Firmicutes,249ZA@186801|Clostridia	186801|Clostridia	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,TrkA_C
WZS1_k127_2002816_7	573413.Spirs_1508	3.98e-67	239.0	COG0030@1|root,COG0030@2|Bacteria,2J65T@203691|Spirochaetes	203691|Spirochaetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
WZS1_k127_2002816_4	1307761.L21SP2_1125	1.166e-114	376.0	COG0329@1|root,COG0329@2|Bacteria,2J5J6@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
WZS1_k127_2002816_5	665571.STHERM_c08680	4.206e-78	268.0	COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
WZS1_k127_2002816_1	665571.STHERM_c08690	1.317e-130	424.0	COG0280@1|root,COG0280@2|Bacteria,2J5DS@203691|Spirochaetes	203691|Spirochaetes	C	phosphate acetyltransferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
WZS1_k127_2002816_6	665571.STHERM_c08700	1.123e-69	245.0	COG0287@1|root,COG0287@2|Bacteria	2|Bacteria	E	prephenate dehydrogenase (NADP+) activity	tyrA	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
WZS1_k127_2002816_10	573413.Spirs_1514	1.137e-34	136.0	COG1664@1|root,COG1664@2|Bacteria,2J861@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
WZS1_k127_2002816_9	573413.Spirs_1515	6.783e-61	216.0	COG0457@1|root,COG0457@2|Bacteria,2J7IN@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
WZS1_k127_2002816_8	573413.Spirs_1518	2.619e-66	241.0	2DRY6@1|root,33DN5@2|Bacteria,2JB74@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2002816_13	1319815.HMPREF0202_02950	9.179e-21	96.0	COG4095@1|root,COG4095@2|Bacteria	2|Bacteria	S	Sugar efflux transporter for intercellular exchange	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
WZS1_k127_2002816_0	1121472.AQWN01000001_gene96	1.375e-162	522.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,260NX@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
WZS1_k127_2002816_3	573413.Spirs_2934	4.029e-125	411.0	COG0263@1|root,COG0263@2|Bacteria,2J6GB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
WZS1_k127_2002816_11	1207058.L53_06750	1.504e-28	118.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,43Y02@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
WZS1_k127_2002816_12	889378.Spiaf_2152	7.225e-23	104.0	2DH0H@1|root,2ZXYI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2002816_2	744872.Spica_1495	1.709e-130	424.0	COG0035@1|root,COG0035@2|Bacteria,2J5NG@203691|Spirochaetes	203691|Spirochaetes	F	uracil phosphoribosyltransferase	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
WZS1_k127_2004707_8	3880.AES58606	1.742e-23	100.0	2CYJ8@1|root,2S4RZ@2759|Eukaryota,37W3F@33090|Viridiplantae,3GKHF@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_15	3880.AES58606	0.0001307	48.0	2CYJ8@1|root,2S4RZ@2759|Eukaryota,37W3F@33090|Viridiplantae,3GKHF@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_5	3880.AES58606	1.741e-32	126.0	2CYJ8@1|root,2S4RZ@2759|Eukaryota,37W3F@33090|Viridiplantae,3GKHF@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_3	29730.Gorai.001G163100.1	8.416e-42	153.0	2E0FB@1|root,2S7VX@2759|Eukaryota,37WZB@33090|Viridiplantae,3GMB0@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_9	4529.ORUFI06G11200.1	1.287e-15	77.0	28YQZ@1|root,2R5IY@2759|Eukaryota,386C7@33090|Viridiplantae,3GU9A@35493|Streptophyta,3M8M3@4447|Liliopsida,3ISV7@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_4	3880.AES58606	6.909e-38	142.0	2CYJ8@1|root,2S4RZ@2759|Eukaryota,37W3F@33090|Viridiplantae,3GKHF@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_16	471870.BACINT_00001	0.0005693	43.0	arCOG05874@1|root,2ZJ01@2|Bacteria,4PK82@976|Bacteroidetes,2FU80@200643|Bacteroidia,4ASE0@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_6	29730.Gorai.001G163000.1	2.761e-31	122.0	arCOG05874@1|root,2SGCB@2759|Eukaryota,37XFP@33090|Viridiplantae,3GMNA@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_2	4113.PGSC0003DMT400027412	9.763e-56	202.0	2CYCC@1|root,2S3JA@2759|Eukaryota,37W9K@33090|Viridiplantae,3GKAK@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2004707_0	3880.AES58577	3.901e-297	915.0	COG0056@1|root,COG0356@1|root,COG1622@1|root,KOG1353@2759|Eukaryota,KOG4665@2759|Eukaryota,KOG4767@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta,4JSJY@91835|fabids	35493|Streptophyta	C	ATP synthase	atp1	-	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,COX2_TM
WZS1_k127_2004707_13	29730.Gorai.012G151800.1	6.493e-05	48.0	COG4799@1|root,KOG0540@2759|Eukaryota,37NPW@33090|Viridiplantae,3GG0Z@35493|Streptophyta	35493|Streptophyta	EI	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963,ko:K02696	ko00061,ko00195,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00195,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Carboxyl_trans,PSI_8
WZS1_k127_2004707_12	3760.EMJ09180	3.744e-05	48.0	COG2801@1|root,KOG0017@2759|Eukaryota,37M1D@33090|Viridiplantae,3GCV5@35493|Streptophyta	35493|Streptophyta	O	DNA RNA polymerases superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Chromo,RVT_1,Retrotrans_gag,rve,zf-H2C2
WZS1_k127_2004707_10	3760.EMJ14251	7.944e-10	60.0	COG2801@1|root,KOG0017@2759|Eukaryota,37M1D@33090|Viridiplantae,3GCV5@35493|Streptophyta	35493|Streptophyta	O	DNA RNA polymerases superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,rve,zf-H2C2
WZS1_k127_2011794_0	889378.Spiaf_0914	2.008e-281	882.0	28HY3@1|root,2Z83I@2|Bacteria	2|Bacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
WZS1_k127_2011794_1	889378.Spiaf_2655	1.626e-163	537.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2027214_2	1123274.KB899441_gene909	1.514e-31	147.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	3.2.1.65	ko:K01212,ko:K12287	ko00500,map00500	-	R05624,R11311	RC03278	ko00000,ko00001,ko01000,ko02044	-	GH32	-	DUF4347,Laminin_G_3,SLH
WZS1_k127_2027214_3	317619.ANKN01000227_gene943	2.215e-07	67.0	COG3210@1|root,COG4995@1|root,COG3210@2|Bacteria,COG4995@2|Bacteria,1G08N@1117|Cyanobacteria,1MMHH@1212|Prochloraceae	2|Bacteria	U	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,Haemagg_act,P_proprotein,TPR_12,TPR_16
WZS1_k127_2027214_0	665571.STHERM_c00960	5.077e-165	589.0	COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,2J6UE@203691|Spirochaetes	203691|Spirochaetes	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig
WZS1_k127_2027214_1	1307761.L21SP2_0473	8.657e-49	195.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_2059872_1	694427.Palpr_0635	5.622e-110	365.0	COG0820@1|root,COG0820@2|Bacteria,4NFH5@976|Bacteroidetes,2FPJH@200643|Bacteroidia,22WJ0@171551|Porphyromonadaceae	976|Bacteroidetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
WZS1_k127_2059872_3	2340.JV46_17170	2.35e-13	79.0	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1J6B6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Oxidoreductase FAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
WZS1_k127_2059872_0	744872.Spica_1248	3.815e-122	408.0	COG0448@1|root,COG0448@2|Bacteria,2J5UB@203691|Spirochaetes	203691|Spirochaetes	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WZS1_k127_2059872_2	1354300.AUQY01000001_gene1377	1.396e-67	236.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,22G0Q@1570339|Peptoniphilaceae	186801|Clostridia	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
WZS1_k127_206446_0	756499.Desde_3411	1.571e-36	154.0	COG1388@1|root,COG3209@1|root,COG3210@1|root,COG1388@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,264FQ@186807|Peptococcaceae	186801|Clostridia	M	YD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LysM,RHS_repeat
WZS1_k127_2067221_2	573413.Spirs_4017	1.06e-149	478.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes	203691|Spirochaetes	C	Oxaloacetate decarboxylase, alpha subunit	oadA	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
WZS1_k127_2067221_12	573413.Spirs_0875	5.596e-22	103.0	2E1WK@1|root,3307R@2|Bacteria,2JBFS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2067221_15	1089548.KI783301_gene117	1.445e-16	87.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,3WEUD@539002|Bacillales incertae sedis	91061|Bacilli	H	5-formyltetrahydrofolate cyclo-ligase family	fthC	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
WZS1_k127_2067221_13	517418.Ctha_2571	1.774e-20	102.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1,GHL10,WG_beta_rep
WZS1_k127_2067221_11	102129.Lepto7375DRAFT_1887	2.184e-29	125.0	2AEGW@1|root,314C3@2|Bacteria,1G5ID@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2067221_4	889378.Spiaf_1749	4.161e-101	338.0	COG2334@1|root,COG2334@2|Bacteria,2J9JA@203691|Spirochaetes	203691|Spirochaetes	S	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
WZS1_k127_2067221_14	1453500.AT05_02645	5.332e-17	86.0	COG2166@1|root,COG2166@2|Bacteria,4NM9N@976|Bacteroidetes,1I187@117743|Flavobacteriia	976|Bacteroidetes	S	SufE protein probably involved in Fe-S center assembly	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
WZS1_k127_2067221_6	497964.CfE428DRAFT_1464	9.887e-77	265.0	COG1179@1|root,COG1179@2|Bacteria,46THP@74201|Verrucomicrobia	74201|Verrucomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
WZS1_k127_2067221_18	1038859.AXAU01000020_gene5445	0.0002614	53.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_8,TolB_N
WZS1_k127_2067221_8	1121428.DESHY_60368___1	6.286e-56	200.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,261JF@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
WZS1_k127_2067221_17	1125700.HMPREF9195_00083	4.886e-05	53.0	2AMVN@1|root,31CSF@2|Bacteria,2J8Q5@203691|Spirochaetes	203691|Spirochaetes	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
WZS1_k127_2067221_3	665571.STHERM_c13430	9.093e-108	359.0	COG0079@1|root,COG0079@2|Bacteria,2J8KB@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9,4.1.1.81	ko:K00817,ko:K04720	ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243,R06530	RC00006,RC00517,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_2067221_16	545695.TREAZ_1548	5.195e-11	67.0	arCOG05759@1|root,33D7Z@2|Bacteria,2J9C2@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF3783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3783
WZS1_k127_2067221_0	573413.Spirs_0929	0.0	1122.0	COG0542@1|root,COG0542@2|Bacteria,2J57C@203691|Spirochaetes	203691|Spirochaetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
WZS1_k127_2067221_1	744872.Spica_0750	4.24e-191	617.0	COG0488@1|root,COG0488@2|Bacteria,2J5AN@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
WZS1_k127_2067221_7	744872.Spica_0749	1.883e-63	234.0	2F4TS@1|root,33XG8@2|Bacteria,2J5NM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
WZS1_k127_2067221_10	1307761.L21SP2_2202	6.478e-38	154.0	COG2885@1|root,COG2885@2|Bacteria,2J5X0@203691|Spirochaetes	203691|Spirochaetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
WZS1_k127_2067221_5	596324.TREVI0001_2258	1.59e-85	300.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2J5H1@203691|Spirochaetes	203691|Spirochaetes	M	Transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
WZS1_k127_2067221_9	545695.TREAZ_3371	1.735e-45	170.0	COG0457@1|root,COG0457@2|Bacteria,2J5XK@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_8
WZS1_k127_2091915_6	743719.PaelaDRAFT_3973	5.736e-46	177.0	COG2207@1|root,COG2207@2|Bacteria,1VIQW@1239|Firmicutes,4IR31@91061|Bacilli,26XKY@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
WZS1_k127_2091915_4	506534.Rhein_1760	1.583e-50	185.0	29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,1S7K0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
WZS1_k127_2091915_1	102125.Xen7305DRAFT_00034920	1.679e-160	527.0	COG1226@1|root,COG1226@2|Bacteria,1G4I2@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	Castor_Poll_mid,TrkA_N
WZS1_k127_2091915_5	665571.STHERM_c21800	4.837e-46	175.0	COG0791@1|root,COG0791@2|Bacteria,2JB19@203691|Spirochaetes	203691|Spirochaetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,NLPC_P60
WZS1_k127_2091915_8	163908.KB235896_gene629	6.977e-40	161.0	2DBUK@1|root,2ZB6C@2|Bacteria,1GFM7@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2091915_3	1121459.AQXE01000008_gene857	1.25e-84	307.0	COG2202@1|root,COG3829@1|root,COG4191@1|root,COG4564@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4564@2|Bacteria,1RCM9@1224|Proteobacteria,42N6Y@68525|delta/epsilon subdivisions,2WJVA@28221|Deltaproteobacteria,2M8BT@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,NMT1,PAS_3,PAS_4,Response_reg,dCache_1,sCache_2
WZS1_k127_2091915_9	1157490.EL26_05940	9.651e-22	103.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,4HB7Q@91061|Bacilli,278DS@186823|Alicyclobacillaceae	91061|Bacilli	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
WZS1_k127_2091915_0	338966.Ppro_0735	3.789e-177	561.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,42MEN@68525|delta/epsilon subdivisions,2WIYF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
WZS1_k127_2091915_2	203119.Cthe_3035	3.828e-146	472.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,3WGQB@541000|Ruminococcaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
WZS1_k127_2091915_7	696747.NIES39_J01290	2.02e-41	169.0	COG0642@1|root,COG2202@1|root,COG3437@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
WZS1_k127_2103372_1	1123274.KB899419_gene1996	9.294e-34	139.0	2F0EQ@1|root,33THS@2|Bacteria,2J5ZQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2103372_0	744872.Spica_1142	1.293e-291	906.0	2EZDZ@1|root,33SJ6@2|Bacteria,2J6M2@203691|Spirochaetes	203691|Spirochaetes	S	Cytoplasmic filament protein A	cfpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2105853_1	1123274.KB899422_gene84	2.255e-16	79.0	COG1561@1|root,COG1561@2|Bacteria,2J76C@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TIGR00255 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
WZS1_k127_2105853_0	889378.Spiaf_2426	4.28e-50	183.0	COG1102@1|root,COG1102@2|Bacteria,2J5P9@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
WZS1_k127_2140190_2	3880.AES58577	1.913e-64	221.0	COG0056@1|root,COG0356@1|root,COG1622@1|root,KOG1353@2759|Eukaryota,KOG4665@2759|Eukaryota,KOG4767@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta,4JSJY@91835|fabids	35493|Streptophyta	C	ATP synthase	atp1	-	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,COX2_TM
WZS1_k127_2140190_5	3880.AES58588	6.025e-25	104.0	2CY54@1|root,2S23H@2759|Eukaryota,3896T@33090|Viridiplantae,3GY43@35493|Streptophyta,4JWBW@91835|fabids	35493|Streptophyta	S	Ribosomal protein S10p/S20e	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WZS1_k127_2140190_7	3880.AES58577	2.201e-21	94.0	COG0056@1|root,COG0356@1|root,COG1622@1|root,KOG1353@2759|Eukaryota,KOG4665@2759|Eukaryota,KOG4767@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta,4JSJY@91835|fabids	35493|Streptophyta	C	ATP synthase	atp1	-	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,COX2_TM
WZS1_k127_2140190_20	143224.JQMD01000002_gene2377	1.242e-05	49.0	2DTVS@1|root,33MVP@2|Bacteria,4NY96@976|Bacteroidetes,1I6YG@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2140190_12	3880.AES58577	4.214e-10	60.0	COG0056@1|root,COG0356@1|root,COG1622@1|root,KOG1353@2759|Eukaryota,KOG4665@2759|Eukaryota,KOG4767@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta,4JSJY@91835|fabids	35493|Streptophyta	C	ATP synthase	atp1	-	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,COX2_TM
WZS1_k127_2140190_1	3880.AES58588	2.427e-81	273.0	2CY54@1|root,2S23H@2759|Eukaryota,3896T@33090|Viridiplantae,3GY43@35493|Streptophyta,4JWBW@91835|fabids	35493|Streptophyta	S	Ribosomal protein S10p/S20e	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WZS1_k127_2140190_4	3880.AES58588	3.756e-25	104.0	2CY54@1|root,2S23H@2759|Eukaryota,3896T@33090|Viridiplantae,3GY43@35493|Streptophyta,4JWBW@91835|fabids	35493|Streptophyta	S	Ribosomal protein S10p/S20e	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WZS1_k127_2140190_3	3694.POPTR_0019s15140.1	1.021e-48	177.0	2CKIK@1|root,2SAZF@2759|Eukaryota,37X7E@33090|Viridiplantae,3GMC4@35493|Streptophyta,4JQKK@91835|fabids	35493|Streptophyta	-	-	-	GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005749,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008177,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016635,GO:0016999,GO:0017144,GO:0019752,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045257,GO:0045273,GO:0045281,GO:0045283,GO:0045333,GO:0055114,GO:0070469,GO:0071704,GO:0072350,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2140190_0	264402.Cagra.26578s0004.1.p	2.343e-166	524.0	COG1845@1|root,KOG4664@2759|Eukaryota,37QER@33090|Viridiplantae,3G8C5@35493|Streptophyta,3HY38@3699|Brassicales	35493|Streptophyta	C	cytochrome c oxidase subunit 3	cox3	-	-	ko:K02262	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX3
WZS1_k127_2140190_10	4081.Solyc11g056450.1.1	7.303e-11	63.0	COG0356@1|root,KOG4665@2759|Eukaryota,37J5M@33090|Viridiplantae,3GEF0@35493|Streptophyta	35493|Streptophyta	C	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel	atp6-1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	-	ko:K02126	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002,ko03029	3.A.2.1	-	-	ATP-synt_A
WZS1_k127_2140190_23	102107.XP_008227624.1	0.000368	49.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37T71@33090|Viridiplantae,3GHK2@35493|Streptophyta,4JS3R@91835|fabids	35493|Streptophyta	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	C2,DUF4283,RVT_1,RVT_3,zf-RVT
WZS1_k127_2140190_6	3694.POPTR_0001s37350.1	3.415e-23	101.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37TIF@33090|Viridiplantae,3G9IZ@35493|Streptophyta,4JVHV@91835|fabids	35493|Streptophyta	S	ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4283,RVT_1,RVT_3,zf-RVT
WZS1_k127_2140190_15	2711.XP_006490008.1	1.402e-08	57.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37T71@33090|Viridiplantae,3GHK2@35493|Streptophyta	35493|Streptophyta	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	C2,DUF4283,RVT_1,RVT_3,zf-RVT
WZS1_k127_2140190_14	90675.XP_010451544.1	9.192e-09	57.0	COG2801@1|root,KOG1075@1|root,KOG0017@2759|Eukaryota,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	ko:K14297	ko03013,ko05164,map03013,map05164	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko03036	1.I.1	-	-	RVT_1,RVT_3,zf-RVT
WZS1_k127_2140190_13	29730.Gorai.001G167400.1	4.638e-10	67.0	298BV@1|root,2RFCF@2759|Eukaryota,37JP6@33090|Viridiplantae,3GEH6@35493|Streptophyta	35493|Streptophyta	C	ATP synthase protein	atp4	-	-	-	-	-	-	-	-	-	-	-	Mt_ATP-synt_B
WZS1_k127_2140190_21	2711.XP_006485826.1	1.323e-05	47.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta	35493|Streptophyta	L	DNA RNA polymerases superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Chromo,RVT_1,Retrotrans_gag,gag-asp_proteas
WZS1_k127_2140190_9	161934.XP_010671929.1	7.807e-12	69.0	COG2801@1|root,KOG0017@2759|Eukaryota,37YGB@33090|Viridiplantae,3GNQA@35493|Streptophyta	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotrans_gag
WZS1_k127_2151637_0	358681.BBR47_39870	0.0	1115.0	COG0300@1|root,COG1020@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	pksM3	-	-	ko:K13611,ko:K13614,ko:K15654	ko01054,ko02024,map01054,map02024	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_2152991_6	545695.TREAZ_0439	5.217e-28	122.0	COG0848@1|root,COG0848@2|Bacteria,2J8F8@203691|Spirochaetes	203691|Spirochaetes	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
WZS1_k127_2152991_5	545694.TREPR_3371	3.556e-33	133.0	2AEDM@1|root,3148E@2|Bacteria,2J8RM@203691|Spirochaetes	203691|Spirochaetes	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
WZS1_k127_2152991_2	889378.Spiaf_2340	1.246e-65	230.0	COG0811@1|root,COG0811@2|Bacteria,2J7RG@203691|Spirochaetes	203691|Spirochaetes	U	Biopolymer transport protein	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
WZS1_k127_2152991_8	889378.Spiaf_2341	1.092e-19	99.0	2BMTQ@1|root,32GD8@2|Bacteria,2JAQ4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2152991_0	889378.Spiaf_2342	2.807e-174	576.0	COG1629@1|root,COG4771@2|Bacteria,2J6M8@203691|Spirochaetes	203691|Spirochaetes	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug
WZS1_k127_2152991_4	391625.PPSIR1_39360	2.099e-41	166.0	COG1028@1|root,COG1028@2|Bacteria,1MWC8@1224|Proteobacteria	1224|Proteobacteria	IQ	PFAM glycoside hydrolase, family 10	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
WZS1_k127_2152991_3	497964.CfE428DRAFT_3107	7.08e-58	225.0	COG1028@1|root,COG2273@1|root,COG1028@2|Bacteria,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	3.2.1.73	ko:K01216	-	-	-	-	ko00000,ko01000	-	-	-	CBM_6,F5_F8_type_C,Glyco_hydro_16
WZS1_k127_2152991_7	1304866.K413DRAFT_5180	1.554e-20	95.0	COG1695@1|root,COG1695@2|Bacteria,1UHRK@1239|Firmicutes,25F64@186801|Clostridia,36UXJ@31979|Clostridiaceae	186801|Clostridia	K	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180,PadR,Vir_act_alpha_C
WZS1_k127_2152991_1	742766.HMPREF9455_01527	2.861e-83	286.0	COG2273@1|root,COG2273@2|Bacteria,4P6MD@976|Bacteroidetes,2FYN8@200643|Bacteroidia,230RQ@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,Glyco_hydro_16
WZS1_k127_2158725_0	1123274.KB899436_gene1284	9.572e-39	158.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
WZS1_k127_2160881_0	1380370.JIBA01000012_gene3757	1.864e-166	546.0	COG0366@1|root,COG0366@2|Bacteria,2GJUT@201174|Actinobacteria,4FEZA@85021|Intrasporangiaceae	201174|Actinobacteria	G	Alpha-amylase domain	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Alpha-amylase,Glyco_hydro_77
WZS1_k127_2160881_1	390874.Tpet_1790	8.959e-12	68.0	COG1609@1|root,COG1609@2|Bacteria,2GCB2@200918|Thermotogae	200918|Thermotogae	K	lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
WZS1_k127_2168599_6	907348.TresaDRAFT_2572	0.0002622	49.0	COG2885@1|root,COG2885@2|Bacteria,2J74V@203691|Spirochaetes	203691|Spirochaetes	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
WZS1_k127_2168599_1	1123274.KB899424_gene3014	1.21e-113	379.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	hoxI	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	EAL,FliG_C,HATPase_c,HisKA,cNMP_binding
WZS1_k127_2168599_2	1123274.KB899419_gene1903	1.079e-71	249.0	2EY48@1|root,33RD4@2|Bacteria,2J65N@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
WZS1_k127_2168599_3	889378.Spiaf_0817	4.912e-63	226.0	2EY48@1|root,3426E@2|Bacteria,2JBFK@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein Flaa	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
WZS1_k127_2168599_5	573413.Spirs_1509	1.325e-20	102.0	2A655@1|root,30UXM@2|Bacteria,2J982@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2168599_4	1123274.KB899409_gene433	1.694e-48	189.0	COG1413@1|root,COG1413@2|Bacteria,2J5TA@203691|Spirochaetes	203691|Spirochaetes	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2168599_0	665571.STHERM_c07830	3.5e-151	487.0	COG2021@1|root,COG2021@2|Bacteria,2JA6P@203691|Spirochaetes	203691|Spirochaetes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
WZS1_k127_2171003_0	313606.M23134_06187	4.109e-159	511.0	COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,47XY7@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	2.5.1.49	ko:K01740,ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01287,R01288,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
WZS1_k127_2171003_1	1121904.ARBP01000001_gene5611	2.862e-43	161.0	COG1765@1|root,COG1765@2|Bacteria,4NNTY@976|Bacteroidetes,47R4T@768503|Cytophagia	976|Bacteroidetes	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
WZS1_k127_2171003_2	744872.Spica_2225	2.217e-29	121.0	COG0707@1|root,COG0707@2|Bacteria,2JABF@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3
WZS1_k127_2181522_3	682795.AciX8_3654	3.342e-51	185.0	COG3832@1|root,COG3832@2|Bacteria,3Y57B@57723|Acidobacteria,2JNMZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
WZS1_k127_2181522_5	187303.BN69_1803	7.593e-29	119.0	COG0640@1|root,COG0640@2|Bacteria,1N0DJ@1224|Proteobacteria,2UC34@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
WZS1_k127_2181522_0	323259.Mhun_2689	1.005e-164	539.0	COG0642@1|root,arCOG02358@2157|Archaea,2XVY8@28890|Euryarchaeota,2N9XQ@224756|Methanomicrobia	224756|Methanomicrobia	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HATPase_c,HisKA,PAS_4
WZS1_k127_2181522_4	439235.Dalk_1601	3.937e-45	166.0	COG0784@1|root,COG0784@2|Bacteria,1QU3I@1224|Proteobacteria	1224|Proteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Hpt,PAS_8,Response_reg
WZS1_k127_2181522_2	118166.JH976538_gene5057	1.573e-86	304.0	COG4191@1|root,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,Response_reg
WZS1_k127_2181522_1	1307761.L21SP2_2602	1.045e-147	477.0	COG3808@1|root,COG3808@2|Bacteria,2J6RD@203691|Spirochaetes	203691|Spirochaetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
WZS1_k127_2196984_1	1123274.KB899436_gene1284	1.289e-08	67.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
WZS1_k127_2200525_1	1307761.L21SP2_0473	1.286e-18	100.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_2200525_0	642492.Clole_2943	7.899e-204	654.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
WZS1_k127_2200525_2	1265505.ATUG01000002_gene1858	0.000946	44.0	2AIDW@1|root,339VZ@2|Bacteria,1NIJ2@1224|Proteobacteria,42XYB@68525|delta/epsilon subdivisions,2WSTD@28221|Deltaproteobacteria,2MM7E@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Nif11
WZS1_k127_2201999_1	981383.AEWH01000014_gene3740	1.901e-26	113.0	COG1131@1|root,COG1131@2|Bacteria,1TQEV@1239|Firmicutes,4IQCY@91061|Bacilli	91061|Bacilli	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WZS1_k127_2201999_2	1237149.C900_00772	0.0001312	50.0	29E7I@1|root,3015I@2|Bacteria,4NNFG@976|Bacteroidetes,47T83@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
WZS1_k127_2201999_0	1200792.AKYF01000017_gene5571	0.0	1062.0	COG0331@1|root,COG2070@1|root,COG3321@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,1UG0E@1239|Firmicutes,4HTY4@91061|Bacilli,274JP@186822|Paenibacillaceae	91061|Bacilli	IQ	Acyl transferase domain	-	-	-	ko:K15329	-	-	-	-	ko00000,ko01008	-	-	-	Acyl_transf_1
WZS1_k127_2206151_4	290434.BG0806	5.939e-34	135.0	COG1057@1|root,COG1057@2|Bacteria,2J65I@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
WZS1_k127_2206151_2	754027.HMPREF9554_00788	1.734e-111	369.0	COG0536@1|root,COG0536@2|Bacteria,2J5QY@203691|Spirochaetes	203691|Spirochaetes	C	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1,Radical_SAM
WZS1_k127_2206151_3	1480694.DC28_01225	6.513e-37	140.0	COG0211@1|root,COG0211@2|Bacteria,2J967@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
WZS1_k127_2206151_6	545695.TREAZ_3494	4.419e-09	62.0	COG2868@1|root,COG2868@2|Bacteria,2J8JE@203691|Spirochaetes	203691|Spirochaetes	J	Pfam:Peptidase_C108	-	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
WZS1_k127_2206151_5	665571.STHERM_c10260	7.638e-34	133.0	COG0261@1|root,COG0261@2|Bacteria,2J7PP@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
WZS1_k127_2206151_0	889378.Spiaf_1889	1.397e-232	730.0	COG0493@1|root,COG0493@2|Bacteria,2J5YC@203691|Spirochaetes	203691|Spirochaetes	C	TIGRFAM glutamate synthases, NADH NADPH, small subunit	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
WZS1_k127_2206151_1	344747.PM8797T_04710	1.004e-173	553.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2IXKD@203682|Planctomycetes	203682|Planctomycetes	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
WZS1_k127_2230426_3	324602.Caur_0349	1.588e-08	63.0	COG1073@1|root,COG1073@2|Bacteria,2G73I@200795|Chloroflexi,375SM@32061|Chloroflexia	32061|Chloroflexia	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WZS1_k127_2230426_2	889378.Spiaf_0918	3.907e-26	115.0	COG1437@1|root,COG1437@2|Bacteria	2|Bacteria	F	CYTH domain	cyaB	-	4.6.1.1	ko:K01768,ko:K05873	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
WZS1_k127_2230426_0	889378.Spiaf_0919	1.115e-55	207.0	28IH6@1|root,2Z8IF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2230426_1	545695.TREAZ_0866	9e-43	164.0	COG0637@1|root,COG0637@2|Bacteria,2J7CH@203691|Spirochaetes	203691|Spirochaetes	S	SPTR Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.18	ko:K01091,ko:K07025	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
WZS1_k127_2233388_0	1536774.H70357_17390	7.821e-05	51.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
WZS1_k127_2238748_0	1499967.BAYZ01000078_gene995	3.239e-130	442.0	COG4913@1|root,COG4913@2|Bacteria	2|Bacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
WZS1_k127_2238748_2	1353529.M899_1754	4.699e-09	69.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
WZS1_k127_2238748_1	1410626.JHXB01000002_gene487	1.625e-12	69.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,27IFJ@186928|unclassified Lachnospiraceae	186801|Clostridia	L	THUMP	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
WZS1_k127_2260361_2	889378.Spiaf_1699	5.701e-63	232.0	COG0719@1|root,COG0719@2|Bacteria,2J5WQ@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
WZS1_k127_2260361_0	744872.Spica_0323	7.575e-234	731.0	COG0719@1|root,COG0719@2|Bacteria,2J5T1@203691|Spirochaetes	203691|Spirochaetes	O	assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
WZS1_k127_2260361_1	1307761.L21SP2_0861	2.915e-112	366.0	COG0396@1|root,COG0396@2|Bacteria,2J5E0@203691|Spirochaetes	203691|Spirochaetes	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
WZS1_k127_2275159_1	1307761.L21SP2_0857	8.534e-111	367.0	COG0550@1|root,COG0550@2|Bacteria,2J5BS@203691|Spirochaetes	203691|Spirochaetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
WZS1_k127_2275159_2	1410609.JHVB01000003_gene325	2.391e-87	306.0	COG0514@1|root,COG0514@2|Bacteria,2J5BY@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
WZS1_k127_2275159_5	880073.Calab_2905	1.442e-10	73.0	COG4676@1|root,COG4676@2|Bacteria	2|Bacteria	UW	Protein conserved in bacteria	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,TPR_11,TPR_12,TPR_2,TPR_7,TPR_8
WZS1_k127_2275159_3	889378.Spiaf_1784	4.431e-73	250.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI	-	3.5.1.124	ko:K03152,ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
WZS1_k127_2275159_4	744872.Spica_0320	1.026e-38	149.0	COG0822@1|root,COG0822@2|Bacteria,2J7U2@203691|Spirochaetes	203691|Spirochaetes	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
WZS1_k127_2275159_0	573413.Spirs_0064	2.443e-145	471.0	COG0520@1|root,COG0520@2|Bacteria,2J61S@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K04487,ko:K11717	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03599,R07460,R11528,R11529	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
WZS1_k127_2288357_0	665571.STHERM_c20200	1.853e-13	85.0	COG3210@1|root,COG3210@2|Bacteria,2J8QW@203691|Spirochaetes	203691|Spirochaetes	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2307354_4	632292.Calhy_0974	5.019e-13	72.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42ESI@68295|Thermoanaerobacterales	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
WZS1_k127_2307354_0	1480694.DC28_14125	2.256e-159	508.0	COG0136@1|root,COG0136@2|Bacteria,2J5ZP@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
WZS1_k127_2307354_1	665571.STHERM_c05460	2.729e-134	441.0	COG0527@1|root,COG0527@2|Bacteria,2J6FK@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
WZS1_k127_2307354_5	635013.TherJR_1814	4.073e-05	54.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,260JZ@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
WZS1_k127_2307354_3	573413.Spirs_1710	2.515e-15	83.0	COG0484@1|root,COG0484@2|Bacteria,2J8JZ@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
WZS1_k127_2307354_2	1123274.KB899428_gene1825	2.846e-115	375.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
WZS1_k127_2308381_1	1307761.L21SP2_2690	7.425e-104	348.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
WZS1_k127_2308381_0	1480694.DC28_11520	9.056e-126	408.0	COG1131@1|root,COG1131@2|Bacteria,2JAJ1@203691|Spirochaetes	203691|Spirochaetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_2308381_3	926550.CLDAP_31590	5.623e-42	162.0	COG0807@1|root,COG1985@1|root,COG0807@2|Bacteria,COG1985@2|Bacteria,2G63D@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K01497,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
WZS1_k127_2308381_2	926550.CLDAP_31600	2.799e-71	253.0	COG1063@1|root,COG1063@2|Bacteria,2G6FN@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
WZS1_k127_2308381_4	1123504.JQKD01000008_gene5341	8.697e-42	164.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
WZS1_k127_2308381_6	1209072.ALBT01000012_gene3408	5.385e-29	120.0	COG0720@1|root,COG0720@2|Bacteria,1QE5R@1224|Proteobacteria,1SAVH@1236|Gammaproteobacteria,1FIAI@10|Cellvibrio	1236|Gammaproteobacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	-	-	-	-	-	-	-	-	-	-	PTPS
WZS1_k127_2308381_5	1210908.HSB1_06020	1.743e-37	152.0	COG0438@1|root,arCOG01411@2157|Archaea,2XUFU@28890|Euryarchaeota,23U4A@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
WZS1_k127_2309147_0	665571.STHERM_c09890	7.439e-118	389.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
WZS1_k127_2313625_13	1198452.Jab_2c25790	7.585e-46	170.0	COG0789@1|root,COG0789@2|Bacteria,1REB7@1224|Proteobacteria,2WEJ4@28216|Betaproteobacteria	28216|Betaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
WZS1_k127_2313625_12	42565.FP66_00610	6.71e-49	186.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1XIGU@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
WZS1_k127_2313625_6	641491.DND132_0078	1.989e-96	325.0	COG3221@1|root,COG3221@2|Bacteria,1R5AR@1224|Proteobacteria,43EBA@68525|delta/epsilon subdivisions,2X07Y@28221|Deltaproteobacteria,2MB4V@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
WZS1_k127_2313625_9	641491.DND132_0079	1.73e-74	258.0	COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,4345F@68525|delta/epsilon subdivisions,2X9WC@28221|Deltaproteobacteria,2MEQY@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	-	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
WZS1_k127_2313625_7	1089552.KI911559_gene3155	2.992e-80	275.0	COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2TV7W@28211|Alphaproteobacteria,2JVVE@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
WZS1_k127_2313625_14	502025.Hoch_4739	4.137e-44	170.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
WZS1_k127_2313625_2	485913.Krac_11579	1.051e-121	402.0	COG1524@1|root,COG1524@2|Bacteria,2G7EG@200795|Chloroflexi	200795|Chloroflexi	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
WZS1_k127_2313625_8	1307761.L21SP2_2616	1.405e-74	256.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	fpr	GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002	FAD_binding_6,NAD_binding_1
WZS1_k127_2313625_0	314607.KB13_1285	3.124e-303	940.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,1KQ66@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
WZS1_k127_2313625_1	396588.Tgr7_0832	1.944e-182	589.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
WZS1_k127_2313625_3	1094715.CM001373_gene1665	1.085e-108	362.0	COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,1RPIZ@1236|Gammaproteobacteria,1JCTI@118969|Legionellales	118969|Legionellales	E	Thiamine biosynthesis oxidoreductase ThiO	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
WZS1_k127_2313625_15	1122134.KB893650_gene277	3.742e-08	61.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
WZS1_k127_2313625_4	349521.HCH_00140	1.324e-105	349.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1XHYB@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
WZS1_k127_2313625_11	297246.lpp1526	5.192e-64	231.0	COG0351@1|root,COG0352@1|root,COG0351@2|Bacteria,COG0352@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1JGMD@118969|Legionellales	118969|Legionellales	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiDE	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,TMP-TENI
WZS1_k127_2313625_5	1382359.JIAL01000001_gene1431	4.981e-98	332.0	COG0476@1|root,COG0476@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia	204432|Acidobacteriia	HP	PFAM UBA THIF-type NAD FAD binding	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
WZS1_k127_2313625_10	1284708.HMPREF1634_08415	2.066e-67	238.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,3WCGZ@538999|Clostridiales incertae sedis	186801|Clostridia	H	Phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7	ko:K00868,ko:K00941,ko:K14153	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
WZS1_k127_2314758_0	1123057.P872_12930	3.077e-151	487.0	COG3459@1|root,COG3459@2|Bacteria,4NIVN@976|Bacteroidetes,47MEX@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
WZS1_k127_2314758_1	1242864.D187_007181	6.295e-09	66.0	COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,42MDW@68525|delta/epsilon subdivisions,2WKQK@28221|Deltaproteobacteria,2YZ11@29|Myxococcales	28221|Deltaproteobacteria	S	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
WZS1_k127_2314758_2	906968.Trebr_2334	1.639e-08	63.0	2A6AA@1|root,30V2X@2|Bacteria,2J9DV@203691|Spirochaetes	203691|Spirochaetes	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2323969_2	1123242.JH636436_gene704	6.513e-07	60.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2323969_0	768710.DesyoDRAFT_2190	1.614e-140	458.0	COG0535@1|root,COG0535@2|Bacteria,1U17E@1239|Firmicutes,25M2T@186801|Clostridia,262BB@186807|Peptococcaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
WZS1_k127_2323969_1	768706.Desor_2068	1.526e-87	299.0	COG0451@1|root,COG0451@2|Bacteria,1TT3X@1239|Firmicutes,24QZG@186801|Clostridia,265X2@186807|Peptococcaceae	186801|Clostridia	GM	PFAM NAD dependent epimerase dehydratase family	-	-	1.1.1.219,1.1.1.412	ko:K00091,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
WZS1_k127_2331260_5	1123274.KB899409_gene615	8.547e-53	191.0	COG0742@1|root,COG0742@2|Bacteria,2J7B5@203691|Spirochaetes	203691|Spirochaetes	L	RNA methyltransferase, RsmD family	yhhF	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
WZS1_k127_2331260_0	1307761.L21SP2_0400	1.766e-148	477.0	COG0482@1|root,COG0482@2|Bacteria,2J6BI@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
WZS1_k127_2331260_1	1307761.L21SP2_2959	6.483e-130	428.0	COG3425@1|root,COG3425@2|Bacteria,2JA2B@203691|Spirochaetes	203691|Spirochaetes	I	Hydroxymethylglutaryl-coenzyme A synthase N terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
WZS1_k127_2331260_2	889378.Spiaf_0376	7.786e-110	366.0	COG1304@1|root,COG1304@2|Bacteria,2JA3N@203691|Spirochaetes	203691|Spirochaetes	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	1.1.1.88,5.3.3.2	ko:K00054,ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123,R02081	RC00004,RC00455,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
WZS1_k127_2331260_3	1307761.L21SP2_2960	2.266e-104	352.0	COG1257@1|root,COG1304@1|root,COG1257@2|Bacteria,COG1304@2|Bacteria,2JA3N@203691|Spirochaetes	203691|Spirochaetes	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	1.1.1.88,5.3.3.2	ko:K00054,ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123,R02081	RC00004,RC00455,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
WZS1_k127_2331260_4	889378.Spiaf_0374	2.215e-78	275.0	COG3407@1|root,COG3407@2|Bacteria,2JACF@203691|Spirochaetes	203691|Spirochaetes	I	GHMP kinases N terminal domain	mvaD	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
WZS1_k127_2331260_6	1480694.DC28_12160	6.889e-37	153.0	COG1577@1|root,COG1577@2|Bacteria,2JARB@203691|Spirochaetes	203691|Spirochaetes	I	GHMP kinases N terminal domain	-	-	2.7.4.2	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R03245	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
WZS1_k127_2331260_7	889378.Spiaf_0372	1.58e-21	100.0	COG1577@1|root,COG1577@2|Bacteria	2|Bacteria	I	mevalonate kinase activity	mvk	-	1.1.1.88,2.3.3.10,2.7.1.36	ko:K00054,ko:K00869,ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,ko04146,map00072,map00280,map00650,map00900,map01100,map01110,map01130,map04146	M00088,M00095	R01978,R02081,R02245	RC00002,RC00004,RC00017,RC00503,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
WZS1_k127_2341958_0	665571.STHERM_c01160	1.652e-96	341.0	COG0643@1|root,COG0643@2|Bacteria,2J9VU@203691|Spirochaetes	203691|Spirochaetes	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
WZS1_k127_2341958_4	1034769.KB910518_gene3512	0.0001347	54.0	COG2197@1|root,COG2197@2|Bacteria,1V207@1239|Firmicutes,4HG4K@91061|Bacilli,26RRA@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, Lux Regulon	ydfI	-	-	ko:K11624	ko02020,map02020	M00484	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
WZS1_k127_2341958_2	679926.Mpet_2338	1.07e-42	174.0	COG0642@1|root,arCOG02385@1|root,arCOG06712@1|root,arCOG02385@2157|Archaea,arCOG06193@2157|Archaea,arCOG06712@2157|Archaea,2XWN9@28890|Euryarchaeota,2NANJ@224756|Methanomicrobia	2157|Archaea	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HATPase_c,PAS,PAS_4,PAS_8,PAS_9,Response_reg
WZS1_k127_2341958_3	573413.Spirs_2908	3.696e-19	92.0	COG0745@1|root,COG0745@2|Bacteria,2JB55@203691|Spirochaetes	203691|Spirochaetes	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
WZS1_k127_2341958_1	1307761.L21SP2_2970	3.842e-67	237.0	2EYA0@1|root,33RIG@2|Bacteria,2J6Q4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2428922_6	1480694.DC28_15195	1.51e-86	302.0	COG0168@1|root,COG0168@2|Bacteria,2J5NF@203691|Spirochaetes	203691|Spirochaetes	P	Potassium uptake protein, TrkH family	ntpJ	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
WZS1_k127_2428922_10	1480694.DC28_15190	1.582e-62	223.0	COG0569@1|root,COG0569@2|Bacteria,2J7SR@203691|Spirochaetes	203691|Spirochaetes	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
WZS1_k127_2428922_17	1237149.C900_00748	1.913e-06	57.0	COG2885@1|root,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,47KG7@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,OmpA,PD40,RicinB_lectin_2
WZS1_k127_2428922_2	706587.Desti_3602	2.141e-216	682.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
WZS1_k127_2428922_3	1480694.DC28_00895	1.584e-189	603.0	COG0004@1|root,COG0004@2|Bacteria,2J5W4@203691|Spirochaetes	203691|Spirochaetes	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
WZS1_k127_2428922_11	744872.Spica_1647	2.394e-59	207.0	COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
WZS1_k127_2428922_4	314724.BT0348	2.645e-169	543.0	COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
WZS1_k127_2428922_14	903818.KI912268_gene1360	1.128e-22	101.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,3Y2IQ@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
WZS1_k127_2428922_13	1417230.AYOT01000223_gene733	8.991e-23	99.0	COG0267@1|root,COG0267@2|Bacteria,2J8UW@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
WZS1_k127_2428922_15	1307761.L21SP2_2710	5.037e-12	67.0	COG0690@1|root,COG0690@2|Bacteria,2J9CX@203691|Spirochaetes	203691|Spirochaetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
WZS1_k127_2428922_8	1480694.DC28_14410	6.735e-67	232.0	COG0250@1|root,COG0250@2|Bacteria,2J7FV@203691|Spirochaetes	203691|Spirochaetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
WZS1_k127_2428922_7	545694.TREPR_0926	2.188e-70	241.0	COG0080@1|root,COG0080@2|Bacteria,2J7BU@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
WZS1_k127_2428922_5	1480694.DC28_14400	1.009e-97	325.0	COG0081@1|root,COG0081@2|Bacteria,2J5HN@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
WZS1_k127_2428922_9	1123274.KB899411_gene3121	1.881e-64	224.0	COG0244@1|root,COG0244@2|Bacteria,2J74F@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
WZS1_k127_2428922_12	889378.Spiaf_0547	3.909e-41	155.0	COG0222@1|root,COG0222@2|Bacteria,2J7NX@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
WZS1_k127_2428922_0	877418.ATWV01000004_gene1932	0.0	1650.0	COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
WZS1_k127_2428922_1	1307761.L21SP2_2703	0.0	1003.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
WZS1_k127_2431938_2	889378.Spiaf_0274	4.815e-133	431.0	COG4213@1|root,COG4213@2|Bacteria,2J5BZ@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10543,ko:K10546	ko02010,map02010	M00215,M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4,3.A.1.2.5	-	-	Peripla_BP_4
WZS1_k127_2431938_0	293826.Amet_2813	7.041e-216	681.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	xylG	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
WZS1_k127_2431938_1	889378.Spiaf_0276	2.257e-145	472.0	COG4214@1|root,COG4214@2|Bacteria,2J5AE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10544,ko:K10547	ko02010,map02010	M00215,M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4,3.A.1.2.5	-	-	BPD_transp_2
WZS1_k127_2431938_4	1385513.N780_18115	2.288e-71	255.0	COG0673@1|root,COG0673@2|Bacteria,1TR8S@1239|Firmicutes,4HBHI@91061|Bacilli,2YBHF@289201|Pontibacillus	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	yvaA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0070402,GO:0097159,GO:0102497,GO:1901265,GO:1901363	1.1.1.371	ko:K16044	ko00562,ko01120,map00562,map01120	-	R09954	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
WZS1_k127_2431938_3	1480694.DC28_10600	2.683e-87	300.0	COG4213@1|root,COG4213@2|Bacteria,2J67U@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
WZS1_k127_2431938_6	1480694.DC28_10605	1.587e-60	228.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J68C@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
WZS1_k127_2431938_5	744872.Spica_1861	1.137e-61	223.0	COG2972@1|root,COG2972@2|Bacteria,2J6F0@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
WZS1_k127_2435851_1	1321815.HMPREF9193_01919	1.249e-76	262.0	COG0104@1|root,COG0104@2|Bacteria,2J6B6@203691|Spirochaetes	203691|Spirochaetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
WZS1_k127_2435851_0	573413.Spirs_2414	1.32e-217	686.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
WZS1_k127_2452342_0	1291050.JAGE01000002_gene3557	1.66e-260	848.0	COG2070@1|root,COG3321@1|root,COG4221@1|root,COG2070@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	pksL	-	-	ko:K13612,ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,Condensation,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NMO,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_2452342_1	882378.RBRH_02573	6.628e-219	729.0	COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2VP69@28216|Betaproteobacteria,1KC4Z@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PKS_DH	rhiE	-	-	ko:K15678	-	-	-	-	ko00000,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_2452342_2	394503.Ccel_0862	1.176e-30	132.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_2458044_6	999630.TUZN_0141	3.581e-05	56.0	COG3386@1|root,arCOG05370@2157|Archaea,2XRWF@28889|Crenarchaeota	28889|Crenarchaeota	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
WZS1_k127_2458044_1	545694.TREPR_2941	2.482e-108	377.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
WZS1_k127_2458044_3	1307761.L21SP2_2016	2.329e-57	211.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
WZS1_k127_2458044_5	1408473.JHXO01000009_gene3474	1.207e-32	133.0	2E6GM@1|root,3313V@2|Bacteria,4NT39@976|Bacteroidetes,2FZCY@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2458044_0	1123228.AUIH01000006_gene2161	3.694e-121	407.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
WZS1_k127_2458044_2	1121459.AQXE01000001_gene2864	1.212e-58	212.0	COG1177@1|root,COG1177@2|Bacteria,1QUMF@1224|Proteobacteria,42NX9@68525|delta/epsilon subdivisions,2WKMT@28221|Deltaproteobacteria,2MAMY@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02053,ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
WZS1_k127_2458044_4	485915.Dret_2123	7.253e-51	186.0	COG1177@1|root,COG1177@2|Bacteria,1R0J7@1224|Proteobacteria,42MDE@68525|delta/epsilon subdivisions,2X86B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
WZS1_k127_2495246_0	754027.HMPREF9554_00882	3.39e-30	130.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J72G@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	lysM	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Amidase_3,LysM,Peptidase_M23
WZS1_k127_2533945_1	3880.AES58606	3.194e-21	93.0	2CYJ8@1|root,2S4RZ@2759|Eukaryota,37W3F@33090|Viridiplantae,3GKHF@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2542084_2	889378.Spiaf_1094	1.457e-52	207.0	28SPJ@1|root,2ZEZR@2|Bacteria,2JB08@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2542084_0	889378.Spiaf_2211	5.288e-119	391.0	COG0825@1|root,COG0825@2|Bacteria,2J5PA@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
WZS1_k127_2542084_1	1480694.DC28_11535	8.668e-72	246.0	COG0777@1|root,COG0777@2|Bacteria,2J5W0@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
WZS1_k127_2547647_1	573413.Spirs_2331	5.614e-287	895.0	COG0556@1|root,COG0556@2|Bacteria,2J57B@203691|Spirochaetes	203691|Spirochaetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
WZS1_k127_2547647_2	1123274.KB899424_gene2972	2.347e-149	483.0	COG0265@1|root,COG0265@2|Bacteria,2J6JY@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WZS1_k127_2547647_4	1121468.AUBR01000090_gene746	3.973e-107	366.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,42EQT@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM Magnesium chelatase, ChlI subunit	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
WZS1_k127_2547647_6	1297742.A176_05561	1.459e-65	239.0	COG5459@1|root,COG5459@2|Bacteria,1MWMM@1224|Proteobacteria,42WIB@68525|delta/epsilon subdivisions,2WRHR@28221|Deltaproteobacteria,2YZNU@29|Myxococcales	28221|Deltaproteobacteria	J	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
WZS1_k127_2547647_7	158189.SpiBuddy_1475	1.476e-47	176.0	COG0328@1|root,COG0328@2|Bacteria,2J7Y2@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
WZS1_k127_2547647_0	573413.Spirs_2335	1.668e-305	945.0	COG0464@1|root,COG0464@2|Bacteria,2J66D@203691|Spirochaetes	203691|Spirochaetes	O	ATPase (AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA
WZS1_k127_2547647_11	1480694.DC28_06775	1.05e-11	74.0	297PQ@1|root,2ZUWM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
WZS1_k127_2547647_3	290397.Adeh_1010	7.941e-108	353.0	COG0262@1|root,COG0262@2|Bacteria,1R5UU@1224|Proteobacteria,42SE7@68525|delta/epsilon subdivisions,2WPK7@28221|Deltaproteobacteria,2YVBX@29|Myxococcales	28221|Deltaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
WZS1_k127_2547647_8	1237149.C900_01932	2.108e-38	153.0	2DBV7@1|root,2ZB9P@2|Bacteria,4NPQU@976|Bacteroidetes,47QI9@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
WZS1_k127_2547647_5	189425.PGRAT_12780	8.385e-82	276.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,4HB82@91061|Bacilli,26UCG@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
WZS1_k127_2547647_10	309798.COPRO5265_1300	8.321e-19	99.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,42FUD@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WZS1_k127_2547647_12	479434.Sthe_3218	1.861e-08	65.0	COG2197@1|root,COG2197@2|Bacteria,2G73R@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
WZS1_k127_2547647_13	1268068.PG5_58010	7.146e-06	49.0	COG0346@1|root,COG0346@2|Bacteria,1RABI@1224|Proteobacteria	1224|Proteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
WZS1_k127_2547647_9	504472.Slin_0809	3.861e-35	136.0	COG0590@1|root,COG0590@2|Bacteria,4NQ98@976|Bacteroidetes,47QRH@768503|Cytophagia	976|Bacteroidetes	FJ	tRNA wobble adenosine to inosine editing	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2553812_2	545694.TREPR_3376	9.931e-08	59.0	2A7RI@1|root,30WQE@2|Bacteria,2JAQ0@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2553812_1	889378.Spiaf_2739	1.021e-133	440.0	COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes	203691|Spirochaetes	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
WZS1_k127_2553812_0	521010.BbiDN127_0175	6.147e-237	741.0	COG0445@1|root,COG0445@2|Bacteria,2J5A1@203691|Spirochaetes	203691|Spirochaetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
WZS1_k127_256932_3	665571.STHERM_c16310	1.67e-44	165.0	COG0330@1|root,COG0330@2|Bacteria,2J5A8@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
WZS1_k127_256932_1	573413.Spirs_2891	6.304e-103	344.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
WZS1_k127_256932_0	1123274.KB899412_gene1492	9.366e-142	465.0	COG0769@1|root,COG0769@2|Bacteria,2J5HR@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WZS1_k127_256932_2	573413.Spirs_3700	2.03e-90	304.0	COG1283@1|root,COG1283@2|Bacteria,2J64N@203691|Spirochaetes	203691|Spirochaetes	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
WZS1_k127_2577285_6	396588.Tgr7_3083	3.931e-116	379.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1SZ87@1236|Gammaproteobacteria,1X2J8@135613|Chromatiales	135613|Chromatiales	P	PFAM ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
WZS1_k127_2577285_20	382464.ABSI01000002_gene4384	3.862e-33	135.0	COG0864@1|root,COG0864@2|Bacteria,46W5K@74201|Verrucomicrobia,2IUN1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	NikR C terminal nickel binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NikR_C,RHH_1
WZS1_k127_2577285_13	1121403.AUCV01000031_gene2815	1.843e-81	279.0	COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,42S17@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Domain of unknown function (DUF1989)	IV02_09290	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
WZS1_k127_2577285_11	396588.Tgr7_3088	1.768e-88	301.0	COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,1RR1E@1236|Gammaproteobacteria,1WW97@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Urea carboxylase-associated protein 1	-	-	-	ko:K09967	-	-	-	-	ko00000	-	-	-	DUF1989
WZS1_k127_2577285_0	225937.HP15_3149	0.0	1246.0	COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,464YG@72275|Alteromonadaceae	1236|Gammaproteobacteria	EI	Allophanate hydrolase subunit 1	uca	-	6.3.4.6,6.4.1.1	ko:K01941,ko:K01959	ko00020,ko00220,ko00620,ko00720,ko00791,ko01100,ko01120,ko01200,ko01230,map00020,map00220,map00620,map00720,map00791,map01100,map01120,map01200,map01230	M00173,M00620	R00344,R00774	RC00040,RC00367,RC00378	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D
WZS1_k127_2577285_24	1210908.HSB1_00910	3.249e-12	78.0	arCOG05875@1|root,arCOG05876@1|root,arCOG05875@2157|Archaea,arCOG05876@2157|Archaea,2XWFY@28890|Euryarchaeota,23UNU@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
WZS1_k127_2577285_26	562743.JH976434_gene876	3.392e-09	66.0	COG1668@1|root,COG1668@2|Bacteria,1V2WV@1239|Firmicutes,4HG9R@91061|Bacilli	91061|Bacilli	CP	transmembrane transport	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
WZS1_k127_2577285_14	189425.PGRAT_15260	3.957e-78	272.0	COG1131@1|root,COG1131@2|Bacteria,1TRNT@1239|Firmicutes,4HB3P@91061|Bacilli,26QX1@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter, ATP-binding protein	-	-	-	ko:K16907	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_2577285_23	171693.BN988_03471	8.401e-16	85.0	COG1309@1|root,COG1309@2|Bacteria,1UV08@1239|Firmicutes,4HW3N@91061|Bacilli,23KSE@182709|Oceanobacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
WZS1_k127_2577285_7	889378.Spiaf_2282	7.728e-111	364.0	COG1028@1|root,COG1028@2|Bacteria	889378.Spiaf_2282|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2577285_5	889378.Spiaf_2283	2.405e-141	455.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
WZS1_k127_2577285_10	889378.Spiaf_2284	7.974e-98	322.0	COG0764@1|root,COG0764@2|Bacteria	2|Bacteria	I	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	fabA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090	FabA
WZS1_k127_2577285_16	56780.SYN_01696	2.543e-66	235.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2MQF5@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
WZS1_k127_2577285_15	889378.Spiaf_2285	1.578e-67	232.0	COG0764@1|root,COG0764@2|Bacteria	2|Bacteria	I	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
WZS1_k127_2577285_1	889378.Spiaf_2286	1.179e-212	666.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
WZS1_k127_2577285_22	889378.Spiaf_2287	9.952e-24	102.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
WZS1_k127_2577285_12	889378.Spiaf_2288	1.116e-84	287.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
WZS1_k127_2577285_25	411154.GFO_1605	6.771e-12	73.0	COG0736@1|root,COG0736@2|Bacteria,4NSJM@976|Bacteroidetes,1I4IR@117743|Flavobacteriia	976|Bacteroidetes	I	4'-phosphopantetheinyl transferase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ACPS
WZS1_k127_2577285_21	584708.Apau_2420	8.207e-31	126.0	COG1959@1|root,COG1959@2|Bacteria,3TBDP@508458|Synergistetes	508458|Synergistetes	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
WZS1_k127_2577285_27	194867.ALBQ01000011_gene384	3.852e-05	47.0	COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2TW4W@28211|Alphaproteobacteria,2JZYG@204457|Sphingomonadales	204457|Sphingomonadales	H	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug
WZS1_k127_2577285_2	1480694.DC28_09755	6.154e-186	587.0	COG0192@1|root,COG0192@2|Bacteria,2J6MD@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
WZS1_k127_2577285_8	596151.DesfrDRAFT_0042	1.114e-110	372.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NJ4@68525|delta/epsilon subdivisions,2WJXN@28221|Deltaproteobacteria,2M84T@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM UMUC domain protein DNA-repair protein	umuC	-	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4113,IMS,IMS_C,IMS_HHH
WZS1_k127_2577285_18	279714.FuraDRAFT_0965	3.212e-42	159.0	COG1974@1|root,COG1974@2|Bacteria,1MZFA@1224|Proteobacteria,2VU86@28216|Betaproteobacteria,2KRGA@206351|Neisseriales	206351|Neisseriales	L	Peptidase S24-like protein	-	-	-	ko:K03503	-	-	-	-	ko00000,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
WZS1_k127_2577285_17	228410.NE0981	2.765e-59	213.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,3731U@32003|Nitrosomonadales	28216|Betaproteobacteria	L	endonuclease III	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
WZS1_k127_2577285_3	583355.Caka_2068	3.351e-170	554.0	COG0154@1|root,COG0154@2|Bacteria,46Z5V@74201|Verrucomicrobia,3K8RD@414999|Opitutae	414999|Opitutae	J	Amidase	-	-	3.5.1.54	ko:K01457	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120	-	R00005	RC02756	ko00000,ko00001,ko01000	-	-	-	Amidase
WZS1_k127_2577285_4	1121033.AUCF01000004_gene4821	6.159e-152	487.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2TSZU@28211|Alphaproteobacteria,2JR1R@204441|Rhodospirillales	204441|Rhodospirillales	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
WZS1_k127_2577285_9	196367.JNFG01000005_gene7285	6.276e-102	342.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VPBQ@28216|Betaproteobacteria,1K43R@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WZS1_k127_2577285_19	335659.S23_21440	5.545e-34	139.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,3JRUB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WZS1_k127_2613363_8	1123274.KB899429_gene2900	8.785e-34	139.0	COG0457@1|root,COG0457@2|Bacteria,2J6BA@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
WZS1_k127_2613363_5	744872.Spica_2180	3.992e-60	217.0	COG0496@1|root,COG0496@2|Bacteria,2J7HR@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
WZS1_k127_2613363_3	545694.TREPR_2801	1.11e-82	288.0	COG0153@1|root,COG0153@2|Bacteria,2J58W@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
WZS1_k127_2613363_4	221027.JO40_01700	1.652e-71	263.0	COG0815@1|root,COG0815@2|Bacteria,2J5UW@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
WZS1_k127_2613363_0	889378.Spiaf_1937	8.917e-223	702.0	COG1158@1|root,COG1158@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
WZS1_k127_2613363_6	457415.HMPREF1006_01537	8.415e-41	156.0	COG1546@1|root,COG1546@2|Bacteria,3TBBV@508458|Synergistetes	508458|Synergistetes	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
WZS1_k127_2613363_7	1307761.L21SP2_1378	1.31e-36	142.0	COG1664@1|root,COG1664@2|Bacteria,2J85N@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
WZS1_k127_2613363_9	573413.Spirs_3182	1.124e-30	123.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4071,GAF,Guanylate_cyc,Pkinase,dCache_1
WZS1_k127_2613363_2	1480694.DC28_03065	9.219e-91	304.0	COG0745@1|root,COG0745@2|Bacteria,2J7JA@203691|Spirochaetes	203691|Spirochaetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WZS1_k127_2613363_1	665571.STHERM_c18560	5.162e-138	454.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
WZS1_k127_2617607_1	1121405.dsmv_2983	2.697e-19	92.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,42QIH@68525|delta/epsilon subdivisions,2WIR8@28221|Deltaproteobacteria,2MM4I@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K02057,ko:K10440,ko:K10538	ko02010,map02010	M00212,M00213,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.2	-	-	BPD_transp_2
WZS1_k127_2617607_0	926550.CLDAP_19670	5.178e-98	325.0	COG1129@1|root,COG1129@2|Bacteria,2G7M7@200795|Chloroflexi	200795|Chloroflexi	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
WZS1_k127_262202_0	744872.Spica_1579	1.192e-56	202.0	COG0773@1|root,COG0773@2|Bacteria,2J5DC@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WZS1_k127_262202_1	665571.STHERM_c12240	2.256e-51	190.0	COG1561@1|root,COG1561@2|Bacteria,2J76C@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TIGR00255 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
WZS1_k127_2640945_0	181119.XP_005528287.1	1.572e-10	73.0	KOG3986@1|root,KOG3986@2759|Eukaryota,38E1I@33154|Opisthokonta,3CNQ0@33208|Metazoa,3E4VV@33213|Bilateria,48RFY@7711|Chordata,49N1S@7742|Vertebrata	33208|Metazoa	OT	Starch/carbohydrate-binding module (family 53)	-	-	-	ko:K07189	ko04910,ko04931,map04910,map04931	-	-	-	ko00000,ko00001,ko01009	-	-	-	CBM_21
WZS1_k127_2643556_1	1087481.AGFX01000038_gene1295	1.538e-56	207.0	COG0500@1|root,COG2226@2|Bacteria,1UYCH@1239|Firmicutes,4HBVC@91061|Bacilli,26RMG@186822|Paenibacillaceae	91061|Bacilli	Q	SAM-dependent methyltransferase	ubiE9	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WZS1_k127_2643556_2	877418.ATWV01000010_gene208	1.889e-40	153.0	2CFGY@1|root,32WTP@2|Bacteria,2J97R@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2643556_3	1235798.C817_03151	2.545e-20	95.0	COG1051@1|root,COG1051@2|Bacteria,1VH0H@1239|Firmicutes,24Q66@186801|Clostridia	186801|Clostridia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
WZS1_k127_2643556_0	1492738.FEM21_28200	7.465e-69	258.0	COG5434@1|root,COG5434@2|Bacteria,4NFSC@976|Bacteroidetes,1I1PY@117743|Flavobacteriia,2NSF2@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Pectate_lyase_3
WZS1_k127_264635_2	99598.Cal7507_0871	0.0007587	49.0	COG2706@1|root,COG2706@2|Bacteria,1G8VQ@1117|Cyanobacteria,1HTQN@1161|Nostocales	1117|Cyanobacteria	G	FG-GAP repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,Lactonase
WZS1_k127_264635_0	573413.Spirs_4132	7.362e-159	528.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,2JBGS@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,NUDIX,PAS_4,Response_reg
WZS1_k127_264635_1	1123274.KB899414_gene3739	4.049e-80	278.0	COG0745@1|root,COG0745@2|Bacteria,2J6F9@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WZS1_k127_2669734_0	3988.XP_002516371.1	1.788e-10	62.0	2CDZ9@1|root,2T2NI@2759|Eukaryota,382AZ@33090|Viridiplantae,3GRK3@35493|Streptophyta	3988.XP_002516371.1|-	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2694135_0	158190.SpiGrapes_2215	1.279e-84	294.0	COG4591@1|root,COG4591@2|Bacteria,2JA02@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WZS1_k127_2694135_1	889378.Spiaf_0170	5.325e-55	201.0	COG2834@1|root,COG2834@2|Bacteria,2J7Z0@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
WZS1_k127_2694135_2	1307761.L21SP2_2222	5.323e-24	115.0	2EG9W@1|root,33A1P@2|Bacteria,2J9F9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_269494_3	1249480.B649_03145	0.0005426	49.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42P4R@68525|delta/epsilon subdivisions,2YM92@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF3365,MCPsignal
WZS1_k127_269494_1	944546.ABED_1113	1.047e-30	124.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions,2YTK2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
WZS1_k127_269494_0	1265505.ATUG01000002_gene1390	1.069e-38	151.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42TN2@68525|delta/epsilon subdivisions,2X5ET@28221|Deltaproteobacteria,2MQ37@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	-	-	-	-	-	-	-	-	-	CheW
WZS1_k127_269494_2	118005.AWNK01000005_gene1448	1.244e-12	76.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	cheD2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
WZS1_k127_2697838_1	1288083.AUKR01000008_gene1694	6.694e-16	80.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	sir	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
WZS1_k127_2697838_0	1265505.ATUG01000001_gene3145	9.571e-122	415.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,42PJ7@68525|delta/epsilon subdivisions,2WMEM@28221|Deltaproteobacteria,2MMTV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
WZS1_k127_2702583_2	269797.Mbar_A2576	2.484e-57	204.0	COG0466@1|root,arCOG02161@2157|Archaea,2XVXA@28890|Euryarchaeota,2N991@224756|Methanomicrobia	224756|Methanomicrobia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
WZS1_k127_2702583_1	1121335.Clst_0287	4.918e-116	387.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3WIA6@541000|Ruminococcaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
WZS1_k127_2702583_3	889378.Spiaf_0370	6.668e-20	100.0	2EFH0@1|root,3399K@2|Bacteria	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
WZS1_k127_2702583_0	313606.M23134_07532	9.094e-129	422.0	28H6T@1|root,2Z7J4@2|Bacteria,4NE4C@976|Bacteroidetes,47K71@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_0	102107.XP_008224000.1	3.907e-287	891.0	28JZI@1|root,2QSDY@2759|Eukaryota,37J4T@33090|Viridiplantae,3GC2Z@35493|Streptophyta,4JREA@91835|fabids	35493|Streptophyta	U	Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope	ycf1	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009706,GO:0009941,GO:0015031,GO:0015833,GO:0016020,GO:0019866,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0033036,GO:0042170,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	-	-	-	-	-	-	-	-	-	Ycf1
WZS1_k127_27109_17	4081.Solyc04g051130.1.1	2.258e-22	96.0	2E6YV@1|root,2SDM4@2759|Eukaryota,37XKW@33090|Viridiplantae,3GMV0@35493|Streptophyta,44UG2@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_29	3649.evm.model.supercontig_107.66	4.698e-13	68.0	COG1404@1|root,KOG1114@2759|Eukaryota,37J68@33090|Viridiplantae,3GDHM@35493|Streptophyta,3HNYX@3699|Brassicales	35493|Streptophyta	O	Tripeptidyl-peptidase	TPP2	GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0005840,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008240,GO:0009507,GO:0009536,GO:0009987,GO:0016020,GO:0016567,GO:0016604,GO:0016787,GO:0017171,GO:0019538,GO:0022626,GO:0031090,GO:0031974,GO:0031981,GO:0032446,GO:0032991,GO:0036211,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044437,GO:0044444,GO:0044445,GO:0044446,GO:0044451,GO:0044464,GO:0070011,GO:0070013,GO:0070647,GO:0071704,GO:0098588,GO:0098805,GO:0140096,GO:1901564,GO:1990904	3.4.14.10	ko:K01280	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8,TPPII
WZS1_k127_27109_11	29730.Gorai.007G194600.1	1.948e-36	139.0	2E2A6@1|root,2S9I6@2759|Eukaryota,37WNR@33090|Viridiplantae,3GKTZ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_1	4155.Migut.D01391.1.p	7.444e-81	269.0	2A03K@1|root,2RXXN@2759|Eukaryota,37U9Z@33090|Viridiplantae,3GIHS@35493|Streptophyta,44N0K@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_15	1347087.CBYO010000002_gene287	1.94e-28	114.0	arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,4HFPA@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_10	3880.AES84212	9.647e-39	144.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta,4JVFX@91835|fabids	35493|Streptophyta	S	Cell wall-associated hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_4	3880.AES84212	4.906e-61	210.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta,4JVFX@91835|fabids	35493|Streptophyta	S	Cell wall-associated hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_16	3885.XP_007141246.1	2.018e-22	102.0	2D5CJ@1|root,2SY3I@2759|Eukaryota,38309@33090|Viridiplantae,3GS5N@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_18	3880.AES84212	1.33e-21	100.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta,4JVFX@91835|fabids	35493|Streptophyta	S	Cell wall-associated hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_9	981085.XP_010104773.1	5.124e-43	157.0	2D340@1|root,2S4ZM@2759|Eukaryota,37WJF@33090|Viridiplantae,3GKNG@35493|Streptophyta,4JV01@91835|fabids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_34	4155.Migut.D01396.1.p	3.787e-11	63.0	2D3FT@1|root,2SREA@2759|Eukaryota,380NY@33090|Viridiplantae,3GQ9H@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_3	4538.ORGLA06G0263600.1	2.085e-70	238.0	2D67G@1|root,2T109@2759|Eukaryota,382H5@33090|Viridiplantae,3GS5U@35493|Streptophyta,3M6V8@4447|Liliopsida,3IQYF@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_36	4113.PGSC0003DMT400089450	6.312e-09	57.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GWDE@35493|Streptophyta,44U28@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_8	3880.AES84212	1.395e-48	174.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta,4JVFX@91835|fabids	35493|Streptophyta	S	Cell wall-associated hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_5	4113.PGSC0003DMT400089450	1.127e-53	190.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GWDE@35493|Streptophyta,44U28@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_28	4555.Si020762m	4.524e-13	76.0	2D4PB@1|root,2SVTX@2759|Eukaryota,3811Z@33090|Viridiplantae,3GQT5@35493|Streptophyta,3M7TA@4447|Liliopsida,3ISA7@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_33	218851.Aquca_010_00668.1	1.761e-11	68.0	2BWAQ@1|root,2R6DI@2759|Eukaryota,3873H@33090|Viridiplantae,3GR06@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_27	3880.AES92423	2.633e-13	70.0	2EPPS@1|root,2SSV1@2759|Eukaryota,380Z0@33090|Viridiplantae,3GQGG@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_38	59689.Al_scaffold_0009_191	5.19e-06	49.0	2EP17@1|root,2SSB9@2759|Eukaryota,380HF@33090|Viridiplantae,3GQ31@35493|Streptophyta,3I1B7@3699|Brassicales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_12	4113.PGSC0003DMT400022655	2.746e-35	134.0	2EA11@1|root,2R918@2759|Eukaryota,389X3@33090|Viridiplantae,3GWEU@35493|Streptophyta,44U83@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_30	3712.Bo01499s030.1	4.734e-13	73.0	2CYKI@1|root,2S503@2759|Eukaryota,37VZS@33090|Viridiplantae,3GKQM@35493|Streptophyta	35493|Streptophyta	S	Protein of unknown function (DUF2647)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2647
WZS1_k127_27109_13	3712.Bo01499s020.1	4.586e-34	130.0	2CYKI@1|root,2S503@2759|Eukaryota,37VZS@33090|Viridiplantae,3GKQM@35493|Streptophyta	35493|Streptophyta	S	Protein of unknown function (DUF2647)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2647
WZS1_k127_27109_23	4081.Solyc09g011150.1.1	2.805e-18	84.0	2EXPB@1|root,2SZAU@2759|Eukaryota,3824W@33090|Viridiplantae,3GRW6@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_7	3649.evm.model.supercontig_2719.1	1.214e-50	181.0	2914Z@1|root,2R80R@2759|Eukaryota,38897@33090|Viridiplantae,3GZ88@35493|Streptophyta,3I1E0@3699|Brassicales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_31	1121875.KB907560_gene528	9.922e-13	68.0	2EK6X@1|root,33DXA@2|Bacteria,4NY6H@976|Bacteroidetes,1I6BA@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_27109_2	4113.PGSC0003DMT400086496	6.474e-75	252.0	COG0048@1|root,KOG1750@2759|Eukaryota	2759|Eukaryota	J	structural constituent of ribosome	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WZS1_k127_27109_6	3712.Bo3g127600.1	3.328e-51	181.0	2E4EA@1|root,2S5QZ@2759|Eukaryota,38A44@33090|Viridiplantae,3GWQ7@35493|Streptophyta,3I1HA@3699|Brassicales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_272454_1	118005.AWNK01000005_gene1654	1.221e-09	63.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
WZS1_k127_272454_0	744872.Spica_0822	6.501e-140	450.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
WZS1_k127_2734177_3	755731.Clo1100_2023	1.882e-16	93.0	COG1721@1|root,COG1721@2|Bacteria,1VA48@1239|Firmicutes,24E5S@186801|Clostridia,36JTY@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WZS1_k127_2734177_0	1007103.AFHW01000178_gene1176	2.115e-78	273.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli,26RVU@186822|Paenibacillaceae	91061|Bacilli	S	magnesium chelatase	yeaC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WZS1_k127_2734177_4	1692.BMAGN_0556	2.215e-10	70.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4CYQW@85004|Bifidobacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
WZS1_k127_2734177_1	1480694.DC28_15135	7.524e-60	213.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	ycaK	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2,UbiA
WZS1_k127_2734177_2	1333998.M2A_2180	2.58e-20	98.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2TUIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
WZS1_k127_280289_5	1121448.DGI_2482	4.044e-17	90.0	COG1177@1|root,COG1177@2|Bacteria,1QX2D@1224|Proteobacteria,43BVP@68525|delta/epsilon subdivisions,2WJS8@28221|Deltaproteobacteria,2M96R@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
WZS1_k127_280289_1	1121456.ATVA01000015_gene2263	2.22e-130	428.0	COG4134@1|root,COG4134@2|Bacteria,1MWJ7@1224|Proteobacteria,42PFD@68525|delta/epsilon subdivisions,2WKQG@28221|Deltaproteobacteria,2M9UX@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
WZS1_k127_280289_3	1121448.DGI_2479	2.286e-78	273.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MKT@68525|delta/epsilon subdivisions,2WJWY@28221|Deltaproteobacteria,2M849@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
WZS1_k127_280289_0	744872.Spica_1334	3.401e-148	482.0	COG0124@1|root,COG0124@2|Bacteria,2J5DX@203691|Spirochaetes	203691|Spirochaetes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
WZS1_k127_280289_2	293826.Amet_3599	3.046e-94	325.0	2CIME@1|root,2Z7XR@2|Bacteria,1VSTH@1239|Firmicutes,24Y3P@186801|Clostridia,36QV3@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_280289_4	573413.Spirs_0254	2.448e-33	132.0	COG0489@1|root,COG0489@2|Bacteria,2J573@203691|Spirochaetes	203691|Spirochaetes	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
WZS1_k127_2821369_0	665571.STHERM_c20270	7.027e-29	128.0	COG2373@1|root,COG2373@2|Bacteria,2J8PU@203691|Spirochaetes	203691|Spirochaetes	S	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5
WZS1_k127_2884696_2	1168034.FH5T_17120	1.537e-09	63.0	2CM5E@1|root,332ZW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2884696_1	1123274.KB899427_gene3294	3.233e-47	177.0	COG0705@1|root,COG0705@2|Bacteria,2J7J3@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	ko:K02441	-	-	-	-	ko00000	-	-	-	Rhomboid
WZS1_k127_2884696_0	906968.Trebr_0685	2.525e-188	600.0	COG1523@1|root,COG1523@2|Bacteria,2J58D@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,PUD
WZS1_k127_289876_1	665571.STHERM_c17990	8.063e-110	367.0	COG0502@1|root,COG0502@2|Bacteria,2J61V@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
WZS1_k127_289876_0	665571.STHERM_c18000	1.159e-195	622.0	COG0502@1|root,COG0502@2|Bacteria,2J6II@203691|Spirochaetes	203691|Spirochaetes	C	Biotin and Thiamin Synthesis associated domain	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
WZS1_k127_289876_4	643562.Daes_0597	7.143e-20	92.0	COG0864@1|root,COG0864@2|Bacteria,1P6QK@1224|Proteobacteria,432KM@68525|delta/epsilon subdivisions,2WX7N@28221|Deltaproteobacteria,2MDAG@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_289876_3	1173021.ALWA01000023_gene2431	9.881e-69	249.0	COG1231@1|root,COG1231@2|Bacteria,1G3IC@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
WZS1_k127_289876_2	203122.Sde_0563	2.814e-92	318.0	COG0366@1|root,COG0366@2|Bacteria,1MVQA@1224|Proteobacteria,1RPA4@1236|Gammaproteobacteria,46654@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0366 Glycosidases	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amyl_C2,Alpha-amylase,Alpha-amylase_C,CBM_20,CBM_48,PKD
WZS1_k127_2905435_1	1144932.ATTF01000003_gene695	4.173e-30	128.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,4BPE2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	chvG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
WZS1_k127_2905435_0	1306947.ARQD01000005_gene54	0.0	1039.0	COG0209@1|root,COG0209@2|Bacteria,2NNRM@2323|unclassified Bacteria	2|Bacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
WZS1_k127_2905435_2	518766.Rmar_0269	3.621e-23	103.0	COG2391@1|root,COG2391@2|Bacteria,4NM6E@976|Bacteroidetes,1FK1T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
WZS1_k127_290841_7	1131462.DCF50_p1653	0.0009772	47.0	COG1433@1|root,COG1433@2|Bacteria,1VW1T@1239|Firmicutes,24KHS@186801|Clostridia	186801|Clostridia	K	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Nitro_FeMo-Co
WZS1_k127_290841_6	517417.Cpar_1627	1.641e-37	145.0	COG3411@1|root,COG3411@2|Bacteria,1FE2Q@1090|Chlorobi	1090|Chlorobi	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_290841_2	290317.Cpha266_0737	9.585e-145	475.0	COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1FDRX@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM nitrogenase cofactor biosynthesis protein NifB	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Nitro_FeMo-Co,Radical_SAM
WZS1_k127_290841_4	331678.Cphamn1_1757	1.718e-74	255.0	COG2710@1|root,COG2710@2|Bacteria,1FDC9@1090|Chlorobi	1090|Chlorobi	C	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
WZS1_k127_290841_3	517417.Cpar_1625	7.784e-89	299.0	COG2710@1|root,COG2710@2|Bacteria,1FDC9@1090|Chlorobi	1090|Chlorobi	C	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
WZS1_k127_290841_1	290512.Paes_1632	2.019e-213	670.0	COG2710@1|root,COG2710@2|Bacteria,1FDCK@1090|Chlorobi	1090|Chlorobi	H	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
WZS1_k127_290841_0	525897.Dbac_0838	1.678e-226	708.0	COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2WIWX@28221|Deltaproteobacteria,2M8N7@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	nifK	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
WZS1_k127_290841_5	331678.Cphamn1_1754	4.359e-73	248.0	COG2710@1|root,COG2710@2|Bacteria,1FDEX@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM nitrogenase molybdenum-iron protein alpha chain	-	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
WZS1_k127_2918170_0	1123274.KB899436_gene1284	2.758e-65	241.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
WZS1_k127_2958613_2	1123274.KB899436_gene1287	8.445e-113	385.0	COG1450@1|root,COG1450@2|Bacteria,2JBI3@203691|Spirochaetes	203691|Spirochaetes	NU	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
WZS1_k127_2958613_7	1461580.CCAS010000015_gene1842	9.764e-05	46.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2958613_1	1123274.KB899417_gene2166	4.287e-124	413.0	COG0544@1|root,COG0544@2|Bacteria,2J5FS@203691|Spirochaetes	203691|Spirochaetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
WZS1_k127_2958613_3	744872.Spica_1111	6.792e-93	308.0	COG0740@1|root,COG0740@2|Bacteria,2J5VY@203691|Spirochaetes	203691|Spirochaetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
WZS1_k127_2958613_0	889378.Spiaf_1139	1.913e-174	558.0	COG1219@1|root,COG1219@2|Bacteria,2J5FF@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
WZS1_k127_2958613_5	498211.CJA_2004	5.019e-14	76.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1FG98@10|Cellvibrio	1236|Gammaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
WZS1_k127_2972835_0	1123274.KB899422_gene85	1.666e-82	284.0	COG0773@1|root,COG0773@2|Bacteria,2J5DC@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WZS1_k127_2972835_2	889378.Spiaf_1899	2.519e-74	261.0	COG0455@1|root,COG0455@2|Bacteria,2J79I@203691|Spirochaetes	203691|Spirochaetes	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	ylxH-3	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	CbiA
WZS1_k127_2972835_1	744872.Spica_0753	3.253e-78	267.0	COG0807@1|root,COG0807@2|Bacteria,2J9XB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	-	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
WZS1_k127_2972835_5	744872.Spica_1705	2.541e-41	153.0	COG0760@1|root,COG0760@2|Bacteria,2J7Z8@203691|Spirochaetes	203691|Spirochaetes	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
WZS1_k127_2972835_4	1461577.CCMH01000009_gene1427	1.829e-44	172.0	COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,1HXBY@117743|Flavobacteriia	976|Bacteroidetes	J	Pseudouridine synthase	rluC	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
WZS1_k127_2972835_3	889378.Spiaf_0586	9.083e-48	190.0	COG4399@1|root,COG4399@2|Bacteria,2JAAN@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
WZS1_k127_2972835_6	744872.Spica_1783	8.879e-05	48.0	2A8H9@1|root,30XJC@2|Bacteria,2JB1E@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_2986098_3	1239962.C943_00480	6.82e-56	205.0	COG0300@1|root,COG0300@2|Bacteria,4NEKV@976|Bacteroidetes,47NJG@768503|Cytophagia	976|Bacteroidetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_2986098_2	573413.Spirs_2763	2.733e-56	207.0	COG0791@1|root,COG4642@1|root,COG0791@2|Bacteria,COG4642@2|Bacteria,2J68J@203691|Spirochaetes	203691|Spirochaetes	M	NlpC P60 family	-	-	-	ko:K13695,ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
WZS1_k127_2986098_0	158190.SpiGrapes_2319	8.304e-103	360.0	COG0826@1|root,COG0826@2|Bacteria,2J667@203691|Spirochaetes	203691|Spirochaetes	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
WZS1_k127_2986098_1	1499967.BAYZ01000027_gene1777	1.224e-76	282.0	COG5001@1|root,COG5001@2|Bacteria,2NP1A@2323|unclassified Bacteria	2|Bacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4084,EAL,GGDEF,MASE3,PAS
WZS1_k127_2996631_2	1480694.DC28_00725	1.074e-41	169.0	COG1729@1|root,COG3071@1|root,COG4105@1|root,COG1729@2|Bacteria,COG3071@2|Bacteria,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K06894,ko:K07114,ko:K08309,ko:K11935,ko:K20543	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3,1.B.33.1,1.B.55.3	GH23	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,VWA_2,YfiO
WZS1_k127_2996631_0	889378.Spiaf_1966	3.024e-71	246.0	COG0811@1|root,COG0811@2|Bacteria,2J700@203691|Spirochaetes	203691|Spirochaetes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
WZS1_k127_2996631_3	744872.Spica_2113	2.356e-40	154.0	COG0848@1|root,COG0848@2|Bacteria,2J82R@203691|Spirochaetes	203691|Spirochaetes	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
WZS1_k127_2996631_1	1307761.L21SP2_1352	1.017e-52	194.0	COG0546@1|root,COG0546@2|Bacteria,2J7JD@203691|Spirochaetes	203691|Spirochaetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
WZS1_k127_3002862_2	1480694.DC28_01775	4.227e-07	59.0	2FG0B@1|root,347X1@2|Bacteria,2J84B@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
WZS1_k127_3002862_0	1307761.L21SP2_1758	5.843e-36	155.0	297HH@1|root,2ZUQS@2|Bacteria,2JBB5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
WZS1_k127_3002862_1	744872.Spica_1402	6.256e-18	87.0	COG1564@1|root,COG1564@2|Bacteria,2J7RD@203691|Spirochaetes	203691|Spirochaetes	H	Thiamin pyrophosphokinase, catalytic domain	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
WZS1_k127_3007117_1	396588.Tgr7_3083	7.991e-29	118.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1SZ87@1236|Gammaproteobacteria,1X2J8@135613|Chromatiales	135613|Chromatiales	P	PFAM ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
WZS1_k127_3007117_0	1298593.TOL_2414	6.51e-129	417.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQ0A@1236|Gammaproteobacteria,1XJ84@135619|Oceanospirillales	135619|Oceanospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
WZS1_k127_3022486_0	1123274.KB899436_gene1284	1.078e-45	190.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
WZS1_k127_3030207_0	889378.Spiaf_0670	2.069e-69	237.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
WZS1_k127_3030207_2	329726.AM1_3783	0.0004077	53.0	COG0457@1|root,COG0457@2|Bacteria,1GD9N@1117|Cyanobacteria	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
WZS1_k127_3030207_1	221027.JO40_12750	0.0002437	51.0	2FHV9@1|root,349NF@2|Bacteria,2J69K@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3057406_1	1121382.JQKG01000028_gene2793	6.989e-44	164.0	COG1028@1|root,COG1028@2|Bacteria,1WM2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_3057406_2	1133850.SHJG_1149	1.42e-07	59.0	COG1028@1|root,COG1028@2|Bacteria,2GJVU@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_3057406_0	1157490.EL26_12090	8.802e-60	219.0	COG2114@1|root,COG2114@2|Bacteria,1V8X9@1239|Firmicutes,4IQCE@91061|Bacilli	91061|Bacilli	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
WZS1_k127_3061549_0	889378.Spiaf_0120	1.98e-213	676.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_3061549_2	32264.tetur01g00040.1	2.811e-09	70.0	COG0666@1|root,KOG0504@2759|Eukaryota,38DDA@33154|Opisthokonta,3BIET@33208|Metazoa,3D2S6@33213|Bilateria	33208|Metazoa	S	Sterile alpha motif.	ANKS3	GO:0008150,GO:0018996,GO:0022404,GO:0032501,GO:0042303,GO:0042395	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,SAM_1
WZS1_k127_3061549_1	866895.HBHAL_4902	3.61e-53	197.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,3NEFR@45667|Halobacillus	91061|Bacilli	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
WZS1_k127_307876_4	1307761.L21SP2_2259	8.888e-19	93.0	2E9WN@1|root,3342D@2|Bacteria,2J71N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_307876_2	1123274.KB899418_gene2366	3.027e-29	118.0	COG0227@1|root,COG0227@2|Bacteria,2J99Q@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
WZS1_k127_307876_1	573413.Spirs_3682	1.707e-76	265.0	COG1235@1|root,COG1235@2|Bacteria,2J7C5@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
WZS1_k127_307876_3	545695.TREAZ_0467	1.448e-20	101.0	2AMQG@1|root,31CKP@2|Bacteria,2J7X3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_307876_5	398720.MED217_12444	2.056e-06	60.0	COG4188@1|root,COG4188@2|Bacteria,4NK4B@976|Bacteroidetes,1I0X2@117743|Flavobacteriia	976|Bacteroidetes	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
WZS1_k127_307876_0	545695.TREAZ_0469	3.827e-118	391.0	COG2089@1|root,COG2089@2|Bacteria,2J662@203691|Spirochaetes	203691|Spirochaetes	M	Sialic acid synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
WZS1_k127_307879_4	545695.TREAZ_0020	1.237e-63	219.0	COG0601@1|root,COG0601@2|Bacteria,2J6BK@203691|Spirochaetes	203691|Spirochaetes	EP	Permease protein	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WZS1_k127_307879_0	869209.Tresu_0140	2.088e-108	361.0	COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02034,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,BPD_transp_1,OppC_N,oligo_HPY
WZS1_k127_307879_2	1336208.JADY01000005_gene1769	3.756e-72	255.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
WZS1_k127_307879_1	545694.TREPR_1530	5.8e-80	279.0	COG4608@1|root,COG4608@2|Bacteria,2J5YH@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
WZS1_k127_307879_3	1499689.CCNN01000014_gene3157	1.354e-68	251.0	COG2199@1|root,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,36WDP@31979|Clostridiaceae	186801|Clostridia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF
WZS1_k127_3090084_2	1297742.A176_03216	9.144e-50	187.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2YUH5@29|Myxococcales	28221|Deltaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_3090084_1	744872.Spica_1253	4.523e-92	318.0	COG1055@1|root,COG1055@2|Bacteria,2J7C2@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1055 Na H antiporter NhaD and related arsenite permease	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
WZS1_k127_3090084_8	1125701.HMPREF1221_00862	1.34e-09	61.0	2ARN0@1|root,31GYP@2|Bacteria,2J925@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3090084_4	1121094.KB894646_gene147	4.413e-40	163.0	COG0577@1|root,COG0577@2|Bacteria,4NGDV@976|Bacteroidetes,2FP9P@200643|Bacteroidia,4AKJ8@815|Bacteroidaceae	976|Bacteroidetes	V	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3090084_6	755732.Fluta_3611	8.696e-31	130.0	COG1136@1|root,COG1136@2|Bacteria,4NN5Z@976|Bacteroidetes,1I3IP@117743|Flavobacteriia,2PBN8@246874|Cryomorphaceae	976|Bacteroidetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_3090084_3	744872.Spica_1008	1.692e-43	180.0	2916B@1|root,2ZNTH@2|Bacteria,2JB3Z@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3090084_7	744872.Spica_2570	2.393e-27	126.0	COG1413@1|root,COG1413@2|Bacteria,2J5TA@203691|Spirochaetes	203691|Spirochaetes	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3090084_0	573413.Spirs_3116	2.41e-106	357.0	COG1226@1|root,COG1226@2|Bacteria,2J72E@203691|Spirochaetes	203691|Spirochaetes	P	TrkA-N domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
WZS1_k127_3090084_5	573413.Spirs_3115	6.579e-40	154.0	COG0664@1|root,COG0664@2|Bacteria,2J8WG@203691|Spirochaetes	203691|Spirochaetes	T	Cyclic nucleotide binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
WZS1_k127_3095560_1	744872.Spica_0481	2.422e-20	96.0	COG0792@1|root,COG0792@2|Bacteria,2J8CV@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
WZS1_k127_3095560_0	744872.Spica_0482	3.058e-56	211.0	COG2206@1|root,COG2206@2|Bacteria,2J6GF@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
WZS1_k127_3095560_2	1123372.AUIT01000002_gene158	4.849e-12	70.0	COG1377@1|root,COG1377@2|Bacteria,2GGWD@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NU	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
WZS1_k127_3097011_2	1196322.A370_03826	3.723e-42	170.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1VQTU@1239|Firmicutes,24D8M@186801|Clostridia,36GZE@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_3097011_3	502025.Hoch_1375	2.64e-27	125.0	COG2304@1|root,COG2304@2|Bacteria,1PDQV@1224|Proteobacteria,43CYI@68525|delta/epsilon subdivisions,2X86P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
WZS1_k127_3097011_1	1123511.KB905859_gene2170	3.41e-172	553.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,4H63B@909932|Negativicutes	909932|Negativicutes	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
WZS1_k127_3097011_0	1121889.AUDM01000002_gene312	6.016e-212	679.0	COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,1HWUI@117743|Flavobacteriia,2NTDC@237|Flavobacterium	976|Bacteroidetes	P	heavy metal translocating P-type ATPase	silP	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WZS1_k127_3115774_0	573413.Spirs_1730	7.55e-69	245.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J7KD@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
WZS1_k127_3115774_1	118797.XP_007472281.1	3.465e-13	80.0	KOG1130@1|root,KOG1130@2759|Eukaryota,39NJP@33154|Opisthokonta,3CQ3W@33208|Metazoa,3E69B@33213|Bilateria,48RPK@7711|Chordata,49N97@7742|Vertebrata,3JGBU@40674|Mammalia	33208|Metazoa	T	Tetratricopeptide repeat domain 28	TTC28	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
WZS1_k127_3149047_5	889378.Spiaf_2673	3.867e-45	173.0	COG1934@1|root,COG1934@2|Bacteria,2J7U8@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
WZS1_k127_3149047_6	889378.Spiaf_2674	3.919e-17	88.0	28XQQ@1|root,2ZJMD@2|Bacteria,2J8Q3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LptC
WZS1_k127_3149047_0	1307761.L21SP2_3301	6.316e-233	731.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
WZS1_k127_3149047_10	1173027.Mic7113_1224	1.87e-09	66.0	COG1259@1|root,COG1259@2|Bacteria,1G4YX@1117|Cyanobacteria,1H904@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Uncharacterised ACR, COG1259	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
WZS1_k127_3149047_3	1123274.KB899414_gene3653	1.856e-113	372.0	COG1352@1|root,COG1352@2|Bacteria,2J5XY@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
WZS1_k127_3149047_1	744872.Spica_2766	1.895e-125	411.0	COG2201@1|root,COG2201@2|Bacteria,2J62V@203691|Spirochaetes	203691|Spirochaetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
WZS1_k127_3149047_4	744872.Spica_2770	1.233e-80	278.0	COG1692@1|root,COG1692@2|Bacteria,2J6ZK@203691|Spirochaetes	203691|Spirochaetes	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
WZS1_k127_3149047_7	215803.DB30_2280	9.869e-16	92.0	COG2819@1|root,COG2819@2|Bacteria,1RAB4@1224|Proteobacteria,43F1Q@68525|delta/epsilon subdivisions,2X30X@28221|Deltaproteobacteria,2YTX8@29|Myxococcales	28221|Deltaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
WZS1_k127_3149047_8	1280390.CBQR020000144_gene3605	1.424e-13	85.0	COG3693@1|root,COG5297@1|root,COG3693@2|Bacteria,COG5297@2|Bacteria,1TT5V@1239|Firmicutes,4HT5P@91061|Bacilli,26SKZ@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_10
WZS1_k127_3149047_9	1237149.C900_01248	8.958e-12	79.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,4NGC8@976|Bacteroidetes	976|Bacteroidetes	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_3149047_2	1196322.A370_05561	6.981e-123	428.0	COG0366@1|root,COG0366@2|Bacteria,1TQSE@1239|Firmicutes,24C4V@186801|Clostridia,36H6T@31979|Clostridiaceae	186801|Clostridia	G	alpha-amylase	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26,CBM53,Y_Y_Y
WZS1_k127_3158399_0	324057.Pjdr2_1338	2.352e-109	364.0	COG1621@1|root,COG1621@2|Bacteria,1TPAE@1239|Firmicutes,4H9Y7@91061|Bacilli,26TPI@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolases family 32	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32C,Glyco_hydro_32N
WZS1_k127_3158399_2	986075.CathTA2_1083	7.371e-51	190.0	COG1028@1|root,COG1028@2|Bacteria,1V1Z9@1239|Firmicutes,4HCPI@91061|Bacilli	91061|Bacilli	IQ	short-chain dehydrogenase	yueD	-	1.1.1.320	ko:K16216	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
WZS1_k127_3158399_1	1123274.KB899421_gene1768	2.718e-86	301.0	COG0728@1|root,COG0728@2|Bacteria,2J697@203691|Spirochaetes	203691|Spirochaetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
WZS1_k127_3176544_1	889378.Spiaf_1650	7.084e-82	288.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
WZS1_k127_3176544_0	1124982.MSI_17310	1.728e-84	296.0	COG1162@1|root,COG1162@2|Bacteria,2J5AI@203691|Spirochaetes	203691|Spirochaetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
WZS1_k127_3176544_4	889378.Spiaf_1652	2.766e-60	218.0	COG0796@1|root,COG0796@2|Bacteria,2J758@203691|Spirochaetes	203691|Spirochaetes	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
WZS1_k127_3176544_7	573413.Spirs_2468	2.087e-38	151.0	COG1357@1|root,COG1357@2|Bacteria,2J652@203691|Spirochaetes	203691|Spirochaetes	S	Pentapeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
WZS1_k127_3176544_6	573413.Spirs_2469	5.716e-45	170.0	COG0491@1|root,COG0491@2|Bacteria,2J7B4@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WZS1_k127_3176544_2	1123274.KB899419_gene1945	1.877e-78	273.0	COG0564@1|root,COG0564@2|Bacteria,2J63B@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil	rluD_1	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
WZS1_k127_3176544_8	1125725.HMPREF1325_1571	8.98e-05	51.0	290S3@1|root,34CB1@2|Bacteria,2JBFT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3176544_5	545695.TREAZ_0707	1.356e-57	208.0	COG0325@1|root,COG0325@2|Bacteria,2J71S@203691|Spirochaetes	203691|Spirochaetes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
WZS1_k127_3176544_3	1303518.CCALI_02632	1.12e-77	263.0	COG0214@1|root,COG0214@2|Bacteria	2|Bacteria	H	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity	pdxS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
WZS1_k127_3188389_4	744872.Spica_1540	9.893e-38	147.0	COG3334@1|root,COG3334@2|Bacteria,2J66F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM MgtE intracellular	flbB	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	-
WZS1_k127_3188389_6	573413.Spirs_1568	2.006e-21	107.0	COG3144@1|root,COG3144@2|Bacteria,2J8AU@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-length control protein	-	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
WZS1_k127_3188389_3	744872.Spica_1538	1.907e-40	154.0	COG1843@1|root,COG1843@2|Bacteria,2J806@203691|Spirochaetes	203691|Spirochaetes	N	flagellar hook	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
WZS1_k127_3188389_0	1123274.KB899413_gene847	1.16e-192	611.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
WZS1_k127_3188389_5	1307761.L21SP2_1187	5.773e-26	107.0	COG1582@1|root,COG1582@2|Bacteria,2J8UC@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar protein FlbD	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
WZS1_k127_3188389_1	665571.STHERM_c09200	1.225e-85	291.0	COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes	203691|Spirochaetes	N	MotA TolQ ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
WZS1_k127_3188389_2	1307761.L21SP2_1189	1.038e-63	224.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
WZS1_k127_3210830_3	573413.Spirs_1735	2.128e-73	255.0	COG0767@1|root,COG0767@2|Bacteria,2J7BX@203691|Spirochaetes	203691|Spirochaetes	Q	ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
WZS1_k127_3210830_2	545694.TREPR_3813	1.269e-86	295.0	COG0613@1|root,COG0613@2|Bacteria,2J69S@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
WZS1_k127_3210830_0	573413.Spirs_1736	3.655e-103	345.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
WZS1_k127_3210830_1	573413.Spirs_1737	3.561e-89	298.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
WZS1_k127_3210830_6	1121946.AUAX01000009_gene4558	9.309e-25	108.0	COG1694@1|root,COG1694@2|Bacteria,2INKJ@201174|Actinobacteria,4DEQB@85008|Micromonosporales	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
WZS1_k127_3210830_4	398578.Daci_2364	2.249e-36	154.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria,4AAGJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
WZS1_k127_3210830_5	112098.XP_008612041.1	5.794e-34	139.0	29HC4@1|root,2RQIP@2759|Eukaryota	2759|Eukaryota	S	Leucyl/phenylalanyl-tRNA protein transferase	-	-	2.3.2.8	ko:K21419	-	-	R03862	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
WZS1_k127_3242910_6	1168034.FH5T_20840	3.341e-39	159.0	COG3437@1|root,COG3437@2|Bacteria,4PMUU@976|Bacteroidetes,2G0H5@200643|Bacteroidia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
WZS1_k127_3242910_4	1150621.SMUL_0160	8.301e-61	215.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC4@68525|delta/epsilon subdivisions,2YMGN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
WZS1_k127_3242910_5	665571.STHERM_c18960	1.43e-50	189.0	COG0398@1|root,COG0398@2|Bacteria,2J8MX@203691|Spirochaetes	203691|Spirochaetes	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WZS1_k127_3242910_7	1540221.JQNI01000002_gene1601	5.89e-38	154.0	COG0697@1|root,COG0697@2|Bacteria,1WJTG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WZS1_k127_3242910_3	889378.Spiaf_1087	1.719e-91	323.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
WZS1_k127_3242910_9	754027.HMPREF9554_00465	1.485e-16	86.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF2156,Rhomboid
WZS1_k127_3242910_8	1123274.KB899411_gene3157	2.929e-31	142.0	COG2982@1|root,COG2982@2|Bacteria,2JBI4@203691|Spirochaetes	203691|Spirochaetes	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3242910_2	502025.Hoch_3203	5.028e-92	332.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2YX8P@29|Myxococcales	28221|Deltaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
WZS1_k127_3242910_1	596152.DesU5LDRAFT_0272	4.091e-98	333.0	COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1QWNG@1224|Proteobacteria,42PE9@68525|delta/epsilon subdivisions,2WJU1@28221|Deltaproteobacteria,2M9H2@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
WZS1_k127_3242910_10	525897.Dbac_2999	1.811e-13	75.0	COG2172@1|root,COG2172@2|Bacteria,1NDH7@1224|Proteobacteria,43BQG@68525|delta/epsilon subdivisions,2X71J@28221|Deltaproteobacteria,2MHD7@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
WZS1_k127_3242910_11	555779.Dthio_PD0237	5.835e-09	61.0	COG1366@1|root,COG1366@2|Bacteria,1NDC7@1224|Proteobacteria,42U42@68525|delta/epsilon subdivisions,2WR39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
WZS1_k127_3242910_0	744872.Spica_0118	6.547e-242	755.0	COG0112@1|root,COG0112@2|Bacteria,2J5XQ@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
WZS1_k127_3242910_12	1307761.L21SP2_1654	1.695e-07	63.0	28QN2@1|root,2ZD3Q@2|Bacteria,2JBB4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans
WZS1_k127_3244060_0	45351.EDO42273	3.673e-06	60.0	29BDQ@1|root,2RIGR@2759|Eukaryota,39XEG@33154|Opisthokonta,3BY63@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF642,TSP_1
WZS1_k127_3283143_18	4081.Solyc00g013160.1.1	0.0001919	44.0	2D0J1@1|root,2SEDM@2759|Eukaryota,37XX0@33090|Viridiplantae,3GMNP@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_7	3880.AES58515	2.561e-21	93.0	2D0J1@1|root,2SEDM@2759|Eukaryota,37XX0@33090|Viridiplantae,3GMNP@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_6	218851.Aquca_023_00075.1	1.643e-24	102.0	COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GEAS@35493|Streptophyta	35493|Streptophyta	C	Proton-conducting membrane transporter	nad4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_3283143_10	29730.Gorai.001G165500.1	5.198e-15	74.0	2D40E@1|root,2STF1@2759|Eukaryota,381GT@33090|Viridiplantae,3GQJZ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_17	29730.Gorai.001G165500.1	6.361e-06	48.0	2D40E@1|root,2STF1@2759|Eukaryota,381GT@33090|Viridiplantae,3GQJZ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_5	29730.Gorai.001G165500.1	2.805e-26	109.0	2D40E@1|root,2STF1@2759|Eukaryota,381GT@33090|Viridiplantae,3GQJZ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_19	29730.Gorai.001G165500.1	0.0002559	44.0	2D40E@1|root,2STF1@2759|Eukaryota,381GT@33090|Viridiplantae,3GQJZ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_13	3988.XP_002535295.1	6.114e-12	69.0	2CZGP@1|root,2SAB4@2759|Eukaryota,37WZW@33090|Viridiplantae,3GKSR@35493|Streptophyta	35493|Streptophyta	-	-	-	-	1.6.5.3	ko:K03878	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADHdh
WZS1_k127_3283143_14	4641.GSMUA_AchrUn_randomP05460_001	8.801e-10	60.0	COG1005@1|root,KOG4770@2759|Eukaryota,37XCB@33090|Viridiplantae,3GMDS@35493|Streptophyta,3M7KX@4447|Liliopsida	35493|Streptophyta	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
WZS1_k127_3283143_2	3649.evm.model.supercontig_263.24	4.825e-51	181.0	2CZGP@1|root,2SAB4@2759|Eukaryota,37WZW@33090|Viridiplantae,3GKSR@35493|Streptophyta,3I0X8@3699|Brassicales	35493|Streptophyta	-	-	-	-	1.6.5.3	ko:K03878	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADHdh
WZS1_k127_3283143_0	3659.XP_004153710.1	1.165e-73	248.0	COG1005@1|root,KOG4770@2759|Eukaryota,37XCB@33090|Viridiplantae,3GKQH@35493|Streptophyta	35493|Streptophyta	C	NADH-ubiquinone oxidoreductase chain	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
WZS1_k127_3283143_9	3880.AES58535	3.115e-18	83.0	2C1H7@1|root,2R1WB@2759|Eukaryota,383JX@33090|Viridiplantae,3GQ6A@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_12	3880.AES58535	5.091e-12	65.0	2C1H7@1|root,2R1WB@2759|Eukaryota,383JX@33090|Viridiplantae,3GQ6A@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_3	29730.Gorai.001G161100.1	5.666e-32	125.0	2C1H7@1|root,2R1WB@2759|Eukaryota,383JX@33090|Viridiplantae,3GQ6A@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3283143_1	3880.AES58514	2.737e-57	201.0	COG0048@1|root,COG0838@1|root,KOG1750@2759|Eukaryota,KOG4662@2759|Eukaryota,37UKS@33090|Viridiplantae,3GIMC@35493|Streptophyta,4JU73@91835|fabids	35493|Streptophyta	J	Ribosomal protein S12/S23	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WZS1_k127_329411_2	665571.STHERM_c00510	2.517e-145	466.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
WZS1_k127_329411_1	889378.Spiaf_2764	1.657e-147	480.0	COG0527@1|root,COG0527@2|Bacteria,2J5C6@203691|Spirochaetes	203691|Spirochaetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
WZS1_k127_329411_7	744872.Spica_2617	3.173e-29	121.0	COG0498@1|root,COG0498@2|Bacteria,2J645@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
WZS1_k127_329411_3	1307761.L21SP2_0073	7.507e-124	406.0	COG0498@1|root,COG0498@2|Bacteria,2J63T@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
WZS1_k127_329411_5	1480694.DC28_09205	5.217e-54	196.0	COG0170@1|root,COG0170@2|Bacteria,2J6YY@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA_1	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_329411_10	744872.Spica_2058	1.425e-06	59.0	290XW@1|root,2ZNJN@2|Bacteria,2J6SW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_329411_6	1307761.L21SP2_0038	2.043e-41	161.0	COG5497@1|root,COG5497@2|Bacteria,2J7E8@203691|Spirochaetes	203691|Spirochaetes	S	Predicted secreted protein (DUF2259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2259
WZS1_k127_329411_0	573413.Spirs_0261	4.193e-224	702.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
WZS1_k127_329411_4	573413.Spirs_0263	1.301e-66	242.0	COG1301@1|root,COG1301@2|Bacteria,2J6P3@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
WZS1_k127_329411_9	573413.Spirs_0264	2.923e-18	94.0	COG4221@1|root,COG4221@2|Bacteria,2J85X@203691|Spirochaetes	203691|Spirochaetes	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_329411_8	1307761.L21SP2_0032	1.464e-19	89.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2J65C@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
WZS1_k127_3311749_12	1480694.DC28_12165	1.613e-13	77.0	COG1577@1|root,COG1577@2|Bacteria	2|Bacteria	I	mevalonate kinase activity	mvk	-	1.1.1.88,2.3.3.10,2.7.1.36	ko:K00054,ko:K00869,ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,ko04146,map00072,map00280,map00650,map00900,map01100,map01110,map01130,map04146	M00088,M00095	R01978,R02081,R02245	RC00002,RC00004,RC00017,RC00503,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
WZS1_k127_3311749_9	1501230.ET33_10625	3.526e-31	130.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,4HGZI@91061|Bacilli,26TQ1@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
WZS1_k127_3311749_7	665571.STHERM_c07460	1.383e-79	279.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J6RF@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
WZS1_k127_3311749_10	243275.TDE_1313	1.113e-21	100.0	COG0681@1|root,COG0681@2|Bacteria,2J81M@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB-3	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
WZS1_k127_3311749_1	1123274.KB899435_gene1312	9.141e-185	596.0	COG0768@1|root,COG0768@2|Bacteria,2J5D8@203691|Spirochaetes	203691|Spirochaetes	M	Cell division protein ftsI	pbp3	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
WZS1_k127_3311749_8	573413.Spirs_2629	2.643e-70	260.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
WZS1_k127_3311749_11	1123274.KB899413_gene828	7.41e-14	78.0	28TF5@1|root,2ZFP6@2|Bacteria,2J8Y7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3311749_13	1123274.KB899413_gene829	4.878e-10	64.0	29A3I@1|root,2ZX4S@2|Bacteria,2J8Z8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3311749_2	744872.Spica_1520	1.656e-181	590.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
WZS1_k127_3311749_4	1123274.KB899413_gene831	2.323e-124	402.0	COG1191@1|root,COG1191@2|Bacteria,2J5RA@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
WZS1_k127_3311749_14	1480694.DC28_02440	0.0001588	51.0	2DCUD@1|root,2ZFDD@2|Bacteria,2J7V4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3311749_3	1480694.DC28_02435	1.443e-132	428.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
WZS1_k127_3311749_6	1123274.KB899413_gene834	9.715e-103	347.0	COG1419@1|root,COG1419@2|Bacteria,2J5TV@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
WZS1_k127_3311749_0	1123274.KB899413_gene835	8.46e-284	887.0	COG1298@1|root,COG1298@2|Bacteria,2J57F@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
WZS1_k127_3311749_5	573413.Spirs_1581	1.338e-119	394.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
WZS1_k127_3341967_0	5145.XP_001907059.1	0.0	1074.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi,3QP1S@4890|Ascomycota,2126Z@147550|Sordariomycetes,3UASY@5139|Sordariales	4751|Fungi	L	WGS project CABT00000000 data, contig	-	GO:0003674,GO:0003824,GO:0003964,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Chromo,Peptidase_A2E,RVT_1,rve
WZS1_k127_3351977_0	1288494.EBAPG3_18910	2.915e-105	357.0	COG0277@1|root,COG0277@2|Bacteria,1RKIM@1224|Proteobacteria,2WB50@28216|Betaproteobacteria,3740K@32003|Nitrosomonadales	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
WZS1_k127_3356765_2	665571.STHERM_c11250	3.06e-22	102.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
WZS1_k127_3356765_1	1307761.L21SP2_1821	6.729e-24	107.0	COG2825@1|root,COG2825@2|Bacteria,2J7PA@203691|Spirochaetes	203691|Spirochaetes	M	Cationic outer membrane protein	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
WZS1_k127_3356765_0	744872.Spica_1349	5.364e-24	104.0	COG1366@1|root,COG1366@2|Bacteria,2JAU8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
WZS1_k127_3363067_2	1480694.DC28_04625	1.297e-170	590.0	COG2373@1|root,COG3420@1|root,COG2373@2|Bacteria,COG3420@2|Bacteria,2J58E@203691|Spirochaetes	203691|Spirochaetes	P	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
WZS1_k127_3363067_3	1307761.L21SP2_3252	1.024e-92	319.0	COG1253@1|root,COG1253@2|Bacteria,2J7S9@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1253 Hemolysins and related protein containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
WZS1_k127_3363067_4	243275.TDE_0826	1.983e-23	100.0	COG3422@1|root,COG3422@2|Bacteria,2J9C1@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF1508)	-	-	-	ko:K09946	-	-	-	-	ko00000	-	-	-	DUF1508
WZS1_k127_3363067_0	665571.STHERM_c03870	0.0	1194.0	COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
WZS1_k127_3363067_5	1125699.HMPREF9194_01319	7.692e-23	114.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
WZS1_k127_3363067_1	298386.PBPRB0417	7.255e-197	645.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,1RZPU@1236|Gammaproteobacteria,1Y29Q@135623|Vibrionales	135623|Vibrionales	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C
WZS1_k127_3364523_1	1380391.JIAS01000017_gene502	1.345e-63	239.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JPID@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
WZS1_k127_3364523_0	706587.Desti_1910	9.159e-72	265.0	COG2203@1|root,COG4191@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,43DA0@68525|delta/epsilon subdivisions,2X8GJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
WZS1_k127_3364523_2	338966.Ppro_3011	5.039e-46	173.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,43CDX@68525|delta/epsilon subdivisions,2X7PU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
WZS1_k127_3371671_4	665571.STHERM_c19210	3.857e-46	186.0	COG4412@1|root,COG4412@2|Bacteria,2JAS0@203691|Spirochaetes	203691|Spirochaetes	S	Peptidase M30	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M30
WZS1_k127_3371671_3	744872.Spica_1316	4.61e-52	187.0	COG3118@1|root,COG3118@2|Bacteria,2JAC7@203691|Spirochaetes	203691|Spirochaetes	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
WZS1_k127_3371671_2	744872.Spica_2841	8.617e-60	222.0	COG2172@1|root,COG2172@2|Bacteria,2J5ZY@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,cNMP_binding
WZS1_k127_3371671_5	1273125.Rrhod_1118	7.652e-39	156.0	COG0523@1|root,COG0523@2|Bacteria,2GKDR@201174|Actinobacteria,4FWEX@85025|Nocardiaceae	201174|Actinobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	cobW	-	-	ko:K02234	-	-	-	-	ko00000,ko00001	-	-	-	CobW_C,cobW
WZS1_k127_3371671_6	653733.Selin_2446	7.622e-23	109.0	COG2215@1|root,COG2215@2|Bacteria	2|Bacteria	O	Belongs to the NiCoT transporter (TC 2.A.52) family	yohM	-	-	ko:K08970	-	-	-	-	ko00000,ko02000	2.A.52.2	-	-	NicO
WZS1_k127_3371671_1	573413.Spirs_2888	1.879e-79	278.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	femA	-	-	-	-	-	-	-	-	-	-	-	FemAB
WZS1_k127_3371671_0	665571.STHERM_c03280	5.052e-320	994.0	COG0143@1|root,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
WZS1_k127_3371671_7	545695.TREAZ_1976	1.253e-21	103.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3390756_0	445970.ALIPUT_00495	3.217e-39	158.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,2FNXM@200643|Bacteroidia,22UD9@171550|Rikenellaceae	976|Bacteroidetes	S	von Willebrand factor type A domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
WZS1_k127_3397202_0	502025.Hoch_1375	6.611e-24	115.0	COG2304@1|root,COG2304@2|Bacteria,1PDQV@1224|Proteobacteria,43CYI@68525|delta/epsilon subdivisions,2X86P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
WZS1_k127_3401946_3	744872.Spica_2370	8.029e-16	79.0	COG0745@1|root,COG0745@2|Bacteria,2J6F9@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WZS1_k127_3401946_2	1307761.L21SP2_2978	5.267e-63	220.0	COG0041@1|root,COG0041@2|Bacteria,2J8QD@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
WZS1_k127_3401946_0	667014.Thein_0471	1.866e-114	388.0	COG0026@1|root,COG0026@2|Bacteria,2GIDQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	ATP-grasp domain	-	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
WZS1_k127_3401946_1	573413.Spirs_0034	1.493e-113	380.0	COG2195@1|root,COG2195@2|Bacteria,2J6ZM@203691|Spirochaetes	203691|Spirochaetes	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
WZS1_k127_340315_5	744872.Spica_1806	1.875e-64	224.0	COG0835@1|root,COG0835@2|Bacteria,2J7NS@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheW-1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
WZS1_k127_340315_9	158189.SpiBuddy_1251	8.504e-16	89.0	COG0399@1|root,COG0399@2|Bacteria,2J6I3@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
WZS1_k127_340315_3	1123274.KB899413_gene883	1.728e-79	274.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
WZS1_k127_340315_0	1123274.KB899413_gene882	2.177e-140	464.0	COG0497@1|root,COG0497@2|Bacteria,2J5E5@203691|Spirochaetes	203691|Spirochaetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
WZS1_k127_340315_4	573413.Spirs_1536	1.012e-78	271.0	2E1YA@1|root,32X70@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_340315_7	744872.Spica_1043	1.484e-28	128.0	2C8R1@1|root,2ZG03@2|Bacteria,2J6QN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_340315_10	906968.Trebr_1666	6.409e-05	54.0	COG0739@1|root,COG0739@2|Bacteria,2JBI9@203691|Spirochaetes	203691|Spirochaetes	M	SPTR M23 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
WZS1_k127_340315_2	545695.TREAZ_0858	1.29e-81	282.0	COG2227@1|root,COG2227@2|Bacteria,2J6CB@203691|Spirochaetes	203691|Spirochaetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
WZS1_k127_340315_1	573413.Spirs_1540	1.837e-101	360.0	COG1449@1|root,COG1449@2|Bacteria,2J742@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
WZS1_k127_340315_8	889378.Spiaf_2126	5.814e-24	111.0	COG3330@1|root,COG3330@2|Bacteria,2J8MZ@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4912)	-	-	-	ko:K09942	-	-	-	-	ko00000	-	-	-	DUF4912
WZS1_k127_340315_6	1089553.Tph_c09150	7.996e-31	124.0	COG1543@1|root,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,248UF@186801|Clostridia,42FVE@68295|Thermoanaerobacterales	186801|Clostridia	G	Domain of unknown function (DUF1957)	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
WZS1_k127_3407456_0	290633.GOX0446	5.509e-107	357.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2JPSN@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
WZS1_k127_3407456_3	1480694.DC28_13795	2.97e-55	197.0	COG0315@1|root,COG0315@2|Bacteria	2|Bacteria	H	cyclic pyranopterin monophosphate synthase activity	moaC	GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
WZS1_k127_3407456_1	1480694.DC28_13800	1.554e-103	351.0	COG0746@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1763@2|Bacteria,2J99J@203691|Spirochaetes	203691|Spirochaetes	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	-	-	-	-	-	-	-	-	-	-	-	-	MobB,NTP_transf_3
WZS1_k127_3407456_2	1480694.DC28_13805	3.428e-80	287.0	COG0303@1|root,COG0303@2|Bacteria	2|Bacteria	H	'Molybdopterin	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
WZS1_k127_3407456_9	1123033.ARNF01000002_gene911	4.292e-14	75.0	COG1977@1|root,COG1977@2|Bacteria,1NAHE@1224|Proteobacteria,1SE6D@1236|Gammaproteobacteria,3NPSP@468|Moraxellaceae	1236|Gammaproteobacteria	H	ThiS family	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
WZS1_k127_3407456_5	1480694.DC28_13815	1.706e-43	167.0	COG0314@1|root,COG0314@2|Bacteria	2|Bacteria	H	molybdopterin synthase activity	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.80,2.8.1.11,2.8.1.12	ko:K03635,ko:K21147	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R07459,R07461,R09395	RC00043,RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
WZS1_k127_3407456_6	1046724.KB889900_gene3205	4.107e-43	172.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,46AKM@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	ThiF family	moeB	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Prok-JAB,Rhodanese,ThiF,ThiS
WZS1_k127_3407456_4	665571.STHERM_c06800	3.785e-44	169.0	COG1180@1|root,COG1180@2|Bacteria,2J6UC@203691|Spirochaetes	203691|Spirochaetes	O	anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
WZS1_k127_3407456_7	1125700.HMPREF9195_00286	2.068e-35	139.0	COG2445@1|root,COG2445@2|Bacteria,2JAVJ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
WZS1_k127_3407456_8	1123354.AUDR01000019_gene164	1.384e-26	117.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2VI19@28216|Betaproteobacteria,1KRDU@119069|Hydrogenophilales	119069|Hydrogenophilales	N	FliG middle domain	-	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
WZS1_k127_3408332_1	4081.Solyc00g142170.2.1	4.585e-13	70.0	2CKHQ@1|root,2SAHI@2759|Eukaryota,37X3N@33090|Viridiplantae,3GM6W@35493|Streptophyta	35493|Streptophyta	S	Mitovirus RNA-dependent RNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Mitovir_RNA_pol
WZS1_k127_3408332_2	4432.XP_010263157.1	0.0002368	47.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3
WZS1_k127_3408332_0	72664.XP_006398026.1	3.526e-263	810.0	COG1290@1|root,KOG4663@2759|Eukaryota,37PDF@33090|Viridiplantae,3GF4E@35493|Streptophyta	35493|Streptophyta	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis	cob	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
WZS1_k127_3417449_0	889378.Spiaf_1968	1.08e-36	157.0	COG1729@1|root,COG3071@1|root,COG4105@1|root,COG1729@2|Bacteria,COG3071@2|Bacteria,COG4105@2|Bacteria,2J6SG@203691|Spirochaetes	203691|Spirochaetes	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
WZS1_k127_3417449_2	1448389.BAVQ01000005_gene3074	1.953e-32	140.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria	201174|Actinobacteria	Q	pyridine nucleotide-disulphide oxidoreductase	rubB	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
WZS1_k127_3417449_1	889378.Spiaf_1351	1.439e-33	136.0	COG0543@1|root,COG0543@2|Bacteria,2J8C6@203691|Spirochaetes	203691|Spirochaetes	C	dihydroorotate dehydrogenase	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
WZS1_k127_3436681_1	621372.ACIH01000203_gene2423	1.815e-46	175.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,26QBT@186822|Paenibacillaceae	91061|Bacilli	S	Protein containing tetrapyrrole methyltransferase domain and MazG-like	yabN	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
WZS1_k127_3436681_0	717605.Theco_3893	4.421e-96	321.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,26QBA@186822|Paenibacillaceae	91061|Bacilli	S	Reductase	yvgN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
WZS1_k127_3439533_4	4432.XP_010278538.1	5.424e-18	84.0	KOG1844@1|root,KOG1844@2759|Eukaryota,37IEA@33090|Viridiplantae,3GBRB@35493|Streptophyta	35493|Streptophyta	S	PHD finger protein MALE	-	GO:0000003,GO:0000212,GO:0000226,GO:0000228,GO:0000280,GO:0000785,GO:0000790,GO:0000791,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005719,GO:0006323,GO:0006355,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007059,GO:0007060,GO:0007140,GO:0007275,GO:0007276,GO:0008134,GO:0008150,GO:0009555,GO:0009889,GO:0009987,GO:0010032,GO:0010468,GO:0010556,GO:0016043,GO:0019219,GO:0019222,GO:0019953,GO:0022402,GO:0022412,GO:0022414,GO:0030154,GO:0030261,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0033613,GO:0042393,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044703,GO:0045132,GO:0048229,GO:0048232,GO:0048235,GO:0048285,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0051321,GO:0051704,GO:0055046,GO:0060255,GO:0065007,GO:0070013,GO:0070192,GO:0071103,GO:0071840,GO:0080090,GO:0097159,GO:0098813,GO:0140013,GO:1901363,GO:1903046,GO:1903506,GO:1990188,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	PHD
WZS1_k127_3439533_2	102107.XP_008244388.1	5.207e-60	211.0	KOG1844@1|root,KOG1844@2759|Eukaryota,37IEA@33090|Viridiplantae,3GBRB@35493|Streptophyta,4JIZM@91835|fabids	35493|Streptophyta	S	PHD finger protein MALE MEIOCYTE DEATH	-	GO:0000003,GO:0000212,GO:0000226,GO:0000228,GO:0000280,GO:0000785,GO:0000790,GO:0000791,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005719,GO:0006323,GO:0006355,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007059,GO:0007060,GO:0007140,GO:0007275,GO:0007276,GO:0008134,GO:0008150,GO:0009555,GO:0009889,GO:0009987,GO:0010032,GO:0010468,GO:0010556,GO:0016043,GO:0019219,GO:0019222,GO:0019953,GO:0022402,GO:0022412,GO:0022414,GO:0030154,GO:0030261,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0033613,GO:0042393,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044703,GO:0045132,GO:0048229,GO:0048232,GO:0048235,GO:0048285,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0051321,GO:0051704,GO:0055046,GO:0060255,GO:0065007,GO:0070013,GO:0070192,GO:0071103,GO:0071840,GO:0080090,GO:0097159,GO:0098813,GO:0140013,GO:1901363,GO:1903046,GO:1903506,GO:1990188,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	PHD
WZS1_k127_3439533_0	3712.Bo00613s200.1	1.302e-171	541.0	COG2801@1|root,KOG0017@2759|Eukaryota,37TAQ@33090|Viridiplantae,3GDDG@35493|Streptophyta,3HXA2@3699|Brassicales	35493|Streptophyta	C	Cytochrome C biogenesis 452	ccmFc	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	-	-	-	-	-	-	-	-	-	-	CcmF_C
WZS1_k127_3439533_6	4006.Lus10027025	2.128e-11	65.0	KOG4197@1|root,KOG4197@2759|Eukaryota	2759|Eukaryota	S	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PPR,PPR_2
WZS1_k127_3439533_1	3880.AES58534	8.557e-146	466.0	COG2801@1|root,KOG0017@2759|Eukaryota,37TAQ@33090|Viridiplantae,3GDDG@35493|Streptophyta,4JUJN@91835|fabids	35493|Streptophyta	L	cytochrome c biogenesis	ccmFc	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	-	-	-	-	-	-	-	-	-	-	CcmF_C
WZS1_k127_3446113_0	3649.evm.model.supercontig_263.6	3.88e-31	125.0	2CPIG@1|root,2R1T5@2759|Eukaryota,383GY@33090|Viridiplantae,3GPY1@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3456687_0	573413.Spirs_1325	5.438e-199	644.0	COG1200@1|root,COG1200@2|Bacteria,2J5ET@203691|Spirochaetes	203691|Spirochaetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
WZS1_k127_3456687_1	987059.RBXJA2T_09062	1.388e-125	419.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2VZKI@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Alkaline phosphatase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
WZS1_k127_3456687_3	929703.KE386491_gene1190	7.621e-40	152.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,4NDXU@976|Bacteroidetes,47M3T@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
WZS1_k127_3456687_2	351348.Maqu_0567	1.113e-45	168.0	COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,1RP83@1236|Gammaproteobacteria,465UG@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
WZS1_k127_3461479_0	1123274.KB899443_gene937	3.063e-15	90.0	2A8FR@1|root,30XHP@2|Bacteria,2JB0S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3461945_3	3694.POPTR_0001s21090.1	2.091e-13	73.0	COG0515@1|root,KOG1187@2759|Eukaryota,37HRN@33090|Viridiplantae,3GACW@35493|Streptophyta,4JFU6@91835|fabids	35493|Streptophyta	T	Belongs to the protein kinase superfamily	-	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004675,GO:0004888,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019199,GO:0019538,GO:0023052,GO:0036211,GO:0038023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.11.1	ko:K04730,ko:K04733	ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,ko05169,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164,map05169	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Pkinase,Pkinase_Tyr
WZS1_k127_3461945_5	3750.XP_008392761.1	1.102e-06	55.0	COG2801@1|root,KOG0017@2759|Eukaryota,37Y16@33090|Viridiplantae,3GNW0@35493|Streptophyta	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
WZS1_k127_3461945_7	37682.EMT07695	2.443e-05	47.0	COG1845@1|root,KOG4664@2759|Eukaryota,37QER@33090|Viridiplantae,3G8C5@35493|Streptophyta,3M1P3@4447|Liliopsida	35493|Streptophyta	C	Subunits I, II and III form the functional core of the enzyme complex	-	-	-	ko:K02262	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX3
WZS1_k127_3461945_1	29730.Gorai.001G161900.1	3.81e-18	84.0	COG0199@1|root,KOG1741@2759|Eukaryota,37W8N@33090|Viridiplantae,3GKAP@35493|Streptophyta	35493|Streptophyta	J	Ribosomal protein S14	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
WZS1_k127_3461945_0	72658.Bostr.12863s0004.1.p	3.861e-94	309.0	2CVK7@1|root,2RS7A@2759|Eukaryota,37RP9@33090|Viridiplantae,3GGMM@35493|Streptophyta	35493|Streptophyta	S	MttB protein	mttB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	-	-	-	-	-	-	-	-	-	TatC
WZS1_k127_3524791_2	1301098.PKB_0424	3.85e-11	65.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
WZS1_k127_3524791_0	1307761.L21SP2_3029	3.85e-199	627.0	COG0137@1|root,COG0137@2|Bacteria,2J5QQ@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
WZS1_k127_3524791_1	665571.STHERM_c20050	9.076e-37	143.0	COG4992@1|root,COG4992@2|Bacteria,2J5X2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WZS1_k127_3533374_6	1125701.HMPREF1221_00411	1.738e-16	85.0	COG2891@1|root,COG2891@2|Bacteria,2J89Q@203691|Spirochaetes	203691|Spirochaetes	M	Rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
WZS1_k127_3533374_3	744872.Spica_1388	3.221e-70	247.0	COG1792@1|root,COG1792@2|Bacteria,2J77U@203691|Spirochaetes	203691|Spirochaetes	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
WZS1_k127_3533374_1	744872.Spica_1389	4.753e-194	608.0	COG1077@1|root,COG1077@2|Bacteria,2J59M@203691|Spirochaetes	203691|Spirochaetes	D	cell shape determining protein, MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
WZS1_k127_3533374_4	1123274.KB899421_gene1806	3.301e-57	210.0	COG0457@1|root,COG0457@2|Bacteria,2J7G0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
WZS1_k127_3533374_7	228405.HNE_0478	1.235e-06	51.0	2DEJE@1|root,2ZN82@2|Bacteria,1PB33@1224|Proteobacteria,2UY1B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3533374_2	1123274.KB899421_gene1808	1.705e-71	249.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
WZS1_k127_3533374_0	545695.TREAZ_0485	4.913e-234	738.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
WZS1_k127_3533374_5	1123274.KB899421_gene1810	1.981e-52	199.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
WZS1_k127_3535575_0	588581.Cpap_0078	0.0	1142.0	COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes	2|Bacteria	Q	synthase	pksR	-	-	ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
WZS1_k127_3535575_7	1121007.AUML01000046_gene4063	5.075e-60	214.0	COG0491@1|root,COG0491@2|Bacteria,4NKGC@976|Bacteroidetes,1I3VC@117743|Flavobacteriia,2YHIE@290174|Aquimarina	976|Bacteroidetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WZS1_k127_3535575_9	1096930.L284_03095	5.707e-17	92.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
WZS1_k127_3535575_5	1121413.JMKT01000009_gene1990	1.663e-91	335.0	COG2204@1|root,COG5002@1|root,COG2204@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MHC1@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
WZS1_k127_3535575_8	515635.Dtur_1752	5.179e-47	195.0	COG1609@1|root,COG2199@1|root,COG1609@2|Bacteria,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	-	-	-	ko:K02103,ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	GAF,GGDEF,Peripla_BP_3
WZS1_k127_3535575_4	545695.TREAZ_3572	3.603e-134	438.0	COG0826@1|root,COG0826@2|Bacteria,2J6QA@203691|Spirochaetes	203691|Spirochaetes	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
WZS1_k127_3535575_6	573413.Spirs_3789	3.23e-71	256.0	COG1876@1|root,COG1876@2|Bacteria,2J72U@203691|Spirochaetes	203691|Spirochaetes	M	Carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
WZS1_k127_3535575_1	1123274.KB899430_gene1685	0.0	1072.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
WZS1_k127_3535575_10	906968.Trebr_1089	5.761e-09	66.0	COG1381@1|root,COG1381@2|Bacteria,2J65J@203691|Spirochaetes	203691|Spirochaetes	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
WZS1_k127_3535575_3	596324.TREVI0001_1402	7.593e-146	474.0	COG0213@1|root,COG0213@2|Bacteria,2J607@203691|Spirochaetes	203691|Spirochaetes	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
WZS1_k127_3535575_2	1123274.KB899430_gene1688	3.43e-159	518.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WZS1_k127_353716_4	86416.Clopa_3943	2.02e-38	149.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,36EQD@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_N,Malt_amylase_C
WZS1_k127_353716_0	889378.Spiaf_0900	8.005e-138	446.0	COG1619@1|root,COG1619@2|Bacteria,2J6NW@203691|Spirochaetes	203691|Spirochaetes	V	LD-carboxypeptidase	ldcA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
WZS1_k127_353716_6	1210884.HG799465_gene11492	2.212e-29	134.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,Esterase
WZS1_k127_353716_1	1033743.CAES01000087_gene2911	1.475e-107	357.0	COG0119@1|root,COG0119@2|Bacteria,1TS0A@1239|Firmicutes,4HEYD@91061|Bacilli,26SU9@186822|Paenibacillaceae	91061|Bacilli	E	Nucleoid-structuring protein H-NS	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
WZS1_k127_353716_3	641524.ADICYQ_0107	3.631e-46	173.0	COG0800@1|root,COG0800@2|Bacteria,4NHVV@976|Bacteroidetes,47MP6@768503|Cytophagia	976|Bacteroidetes	G	KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
WZS1_k127_353716_2	744872.Spica_2258	2.845e-82	278.0	COG0288@1|root,COG0288@2|Bacteria,2JABE@203691|Spirochaetes	203691|Spirochaetes	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
WZS1_k127_353716_5	158190.SpiGrapes_1256	1.792e-32	135.0	2BYH0@1|root,2ZDJM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3546956_2	751945.Theos_0271	3.321e-05	56.0	COG1470@1|root,COG3895@1|root,COG1470@2|Bacteria,COG3895@2|Bacteria,1WIA5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,PEGA
WZS1_k127_3546956_0	1415778.JQMM01000001_gene1842	2.254e-75	261.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1J5CU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
WZS1_k127_3546956_1	754027.HMPREF9554_00298	2.512e-27	118.0	2EQ1S@1|root,33HN8@2|Bacteria,2J7UJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3551106_2	1230342.CTM_07001	2.447e-27	117.0	COG4635@1|root,COG4635@2|Bacteria,1VBP3@1239|Firmicutes,24JC3@186801|Clostridia,36JH5@31979|Clostridiaceae	186801|Clostridia	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
WZS1_k127_3551106_1	665571.STHERM_c20340	3.808e-76	263.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	nodJ	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
WZS1_k127_3551106_0	1307761.L21SP2_2583	3.184e-113	373.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
WZS1_k127_3551106_3	1302858.I871_02395	6.446e-05	47.0	COG0438@1|root,COG0438@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
WZS1_k127_355258_1	118005.AWNK01000005_gene1654	1.212e-25	107.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
WZS1_k127_355258_0	118005.AWNK01000005_gene1653	1.02e-57	206.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
WZS1_k127_355258_2	351160.RCIX772	4.001e-06	54.0	arCOG10439@1|root,arCOG10439@2157|Archaea,2Y63F@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF3788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3788
WZS1_k127_355258_3	545695.TREAZ_2246	6.371e-05	46.0	2DRMH@1|root,33CAH@2|Bacteria,2J8VW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3566995_7	768706.Desor_2066	1.782e-24	106.0	COG0611@1|root,COG0611@2|Bacteria,1V0SM@1239|Firmicutes,24J04@186801|Clostridia	186801|Clostridia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WZS1_k127_3566995_3	768710.DesyoDRAFT_2186	1.427e-68	244.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
WZS1_k127_3566995_0	768704.Desmer_2111	4.851e-115	383.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,261UX@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_3566995_9	1125701.HMPREF1221_00459	0.0005378	48.0	COG0236@1|root,COG0236@2|Bacteria,2J8CN@203691|Spirochaetes	203691|Spirochaetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
WZS1_k127_3566995_1	768704.Desmer_2109	9.154e-115	382.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
WZS1_k127_3566995_2	768710.DesyoDRAFT_2182	2.354e-84	291.0	COG0382@1|root,COG0382@2|Bacteria,1VQU0@1239|Firmicutes,24ZBN@186801|Clostridia	186801|Clostridia	H	PFAM UbiA prenyltransferase family	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
WZS1_k127_3566995_5	1307761.L21SP2_3018	2.31e-55	201.0	COG3797@1|root,COG3797@2|Bacteria,2J5X6@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
WZS1_k127_3566995_4	1158607.UAU_03950	1.133e-55	220.0	COG1262@1|root,COG1262@2|Bacteria,1V03B@1239|Firmicutes,4IPQW@91061|Bacilli	91061|Bacilli	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
WZS1_k127_3566995_6	552396.HMPREF0863_01193	4.527e-34	151.0	COG2340@1|root,COG3209@1|root,COG4886@1|root,COG5492@1|root,COG2340@2|Bacteria,COG3209@2|Bacteria,COG4886@2|Bacteria,COG5492@2|Bacteria,1UKK2@1239|Firmicutes,3VUUT@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Listeria-Bacteroides repeat domain (List_Bact_rpt)	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new
WZS1_k127_3566995_8	235909.GK0183	0.0003881	44.0	COG2318@1|root,COG2318@2|Bacteria,1V8A0@1239|Firmicutes,4HIW8@91061|Bacilli,1WGBX@129337|Geobacillus	91061|Bacilli	S	Protein of unknown function (DUF1569)	yuaE	-	-	-	-	-	-	-	-	-	-	-	DinB_2
WZS1_k127_3569471_1	158190.SpiGrapes_2094	2.895e-55	199.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
WZS1_k127_3569471_0	530564.Psta_3290	4.175e-88	305.0	COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
WZS1_k127_3571342_2	485916.Dtox_2866	3.183e-27	124.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
WZS1_k127_3571342_0	485916.Dtox_2867	6.888e-155	502.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,26498@186807|Peptococcaceae	186801|Clostridia	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
WZS1_k127_3571342_1	1124982.MSI_10980	3.378e-97	323.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
WZS1_k127_3592786_0	3656.XP_008441940.1	3.25e-13	70.0	COG1204@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG0952@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta	35493|Streptophyta	O	Mitochondrial protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,zf-CCHC
WZS1_k127_3608420_6	1128398.Curi_c08960	7.092e-14	79.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,24HIG@186801|Clostridia,269IG@186813|unclassified Clostridiales	186801|Clostridia	S	Protein of unknown function (DUF1648)	sdpI	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
WZS1_k127_3608420_4	744872.Spica_2469	8.583e-33	140.0	COG2267@1|root,COG2267@2|Bacteria,2JAFJ@203691|Spirochaetes	203691|Spirochaetes	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WZS1_k127_3608420_0	326298.Suden_1734	4.474e-163	525.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2YMW3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
WZS1_k127_3608420_8	545695.TREAZ_0666	1.64e-07	63.0	2F1XI@1|root,33UX3@2|Bacteria,2J59N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3608420_2	888055.HMPREF9015_00294	6.206e-76	272.0	COG2148@1|root,COG2148@2|Bacteria,378EQ@32066|Fusobacteria	32066|Fusobacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
WZS1_k127_3608420_5	760011.Spico_1478	5.19e-30	137.0	2ECQK@1|root,336N8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
WZS1_k127_3608420_3	1307761.L21SP2_3109	1.137e-58	226.0	2BYRY@1|root,33K7C@2|Bacteria,2J6CE@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3608420_1	472759.Nhal_0700	2.037e-81	286.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RRWX@1236|Gammaproteobacteria,1WYF9@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
WZS1_k127_3608420_7	1236902.ANAS01000034_gene1081	1.351e-13	73.0	COG0438@1|root,COG0438@2|Bacteria,2GJBP@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Stealth_CR1,Stealth_CR2,Stealth_CR3,Stealth_CR4
WZS1_k127_3613239_3	744872.Spica_0675	7.705e-55	199.0	2920H@1|root,2ZPJT@2|Bacteria,2J5PN@203691|Spirochaetes	203691|Spirochaetes	S	Pilus assembly protein PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
WZS1_k127_3613239_2	1480694.DC28_02640	2.224e-84	292.0	COG0457@1|root,COG0457@2|Bacteria,2J5UY@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7,TPR_8
WZS1_k127_3613239_1	744872.Spica_1128	3.697e-132	427.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
WZS1_k127_3613239_0	744872.Spica_1127	2.04e-136	438.0	COG1344@1|root,COG1344@2|Bacteria,2J5NR@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
WZS1_k127_3613239_5	744872.Spica_1126	6.309e-18	88.0	COG1334@1|root,COG1334@2|Bacteria,2J8TD@203691|Spirochaetes	203691|Spirochaetes	N	FlaG protein	flaG	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
WZS1_k127_3613239_4	1307761.L21SP2_1238	5.106e-51	191.0	COG1345@1|root,COG1345@2|Bacteria,2J6CW@203691|Spirochaetes	203691|Spirochaetes	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
WZS1_k127_3636887_10	244582.JQAK01000001_gene1835	2.823e-41	162.0	COG2977@1|root,COG2977@2|Bacteria,1PKWJ@1224|Proteobacteria,2UZID@28211|Alphaproteobacteria,47GNV@766|Rickettsiales	766|Rickettsiales	Q	4'-phosphopantetheinyl transferase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ACPS
WZS1_k127_3636887_11	1268072.PSAB_04085	3.826e-26	109.0	COG3708@1|root,COG3708@2|Bacteria,1VJT1@1239|Firmicutes,4HREN@91061|Bacilli,26Z6R@186822|Paenibacillaceae	91061|Bacilli	K	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
WZS1_k127_3636887_8	1307761.L21SP2_0317	8.079e-46	183.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3636887_6	1480694.DC28_06815	1.358e-51	192.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
WZS1_k127_3636887_5	1307761.L21SP2_0315	4.058e-57	216.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WZS1_k127_3636887_4	1307761.L21SP2_0314	2.233e-74	268.0	COG0577@1|root,COG0577@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
WZS1_k127_3636887_1	158190.SpiGrapes_2915	7.375e-97	321.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_3636887_9	765911.Thivi_0101	1.458e-41	168.0	COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,1S89B@1236|Gammaproteobacteria,1X28C@135613|Chromatiales	135613|Chromatiales	P	DsrE/DsrF-like family	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
WZS1_k127_3636887_3	1260251.SPISAL_04980	1.145e-76	271.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,1RNUU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
WZS1_k127_3636887_7	388051.AUFE01000053_gene4974	3.958e-50	186.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,2VI9S@28216|Betaproteobacteria,1K7KF@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
WZS1_k127_3636887_12	744872.Spica_2622	1.125e-24	108.0	COG0640@1|root,COG0640@2|Bacteria,2JAK1@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
WZS1_k127_3636887_2	1121004.ATVC01000040_gene2384	1.839e-96	338.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,2KU4C@206351|Neisseriales	206351|Neisseriales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
WZS1_k127_3636887_0	1121405.dsmv_2296	4.161e-294	922.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,43C0D@68525|delta/epsilon subdivisions,2WIYN@28221|Deltaproteobacteria,2MHY4@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10
WZS1_k127_367109_0	3988.XP_002534951.1	8.875e-135	432.0	COG1622@1|root,KOG4767@2759|Eukaryota,37T4F@33090|Viridiplantae,3GGAX@35493|Streptophyta,4JT1W@91835|fabids	35493|Streptophyta	C	Cytochrome C oxidase, subunit	cox2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0042773,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564	-	ko:K02261	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX2,COX2_TM
WZS1_k127_371748_4	1313304.CALK_0494	2.927e-39	156.0	COG0373@1|root,COG0373@2|Bacteria	2|Bacteria	H	glutamyl-tRNA reductase activity	hemA	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	1.2.1.70	ko:K02407,ko:K02492	ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000,ko02035	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
WZS1_k127_371748_0	1347393.HG726020_gene950	9.506e-140	471.0	COG0007@1|root,COG0181@1|root,COG1587@1|root,COG0007@2|Bacteria,COG0181@2|Bacteria,COG1587@2|Bacteria,4NFVR@976|Bacteroidetes,2G3DU@200643|Bacteroidia,4AVHR@815|Bacteroidaceae	976|Bacteroidetes	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
WZS1_k127_371748_3	429009.Adeg_1257	1.425e-94	320.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
WZS1_k127_371748_1	357808.RoseRS_1753	6.981e-139	453.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,374V4@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WZS1_k127_371748_5	1499967.BAYZ01000155_gene612	8.167e-10	68.0	COG1648@1|root,COG1648@2|Bacteria	2|Bacteria	H	precorrin-2 dehydrogenase activity	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
WZS1_k127_371748_2	404380.Gbem_0089	8.59e-102	341.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,42P68@68525|delta/epsilon subdivisions,2WMKD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
WZS1_k127_3718258_0	1480694.DC28_00325	1.817e-95	319.0	COG0024@1|root,COG0024@2|Bacteria,2J5Z7@203691|Spirochaetes	203691|Spirochaetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
WZS1_k127_3721035_8	1236976.JCM16418_279	1.469e-25	106.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,26T3H@186822|Paenibacillaceae	91061|Bacilli	C	Converts isocitrate to alpha ketoglutarate	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
WZS1_k127_3721035_10	1125699.HMPREF9194_00884	1.942e-13	78.0	2AMU1@1|root,31CQJ@2|Bacteria,2J8GB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3721035_9	1307761.L21SP2_0278	6.902e-18	90.0	28VUA@1|root,2ZHVZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3721035_1	158189.SpiBuddy_1224	9.404e-103	351.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
WZS1_k127_3721035_5	1123274.KB899422_gene26	1.904e-68	242.0	COG0846@1|root,COG0846@2|Bacteria,2J6BW@203691|Spirochaetes	203691|Spirochaetes	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
WZS1_k127_3721035_0	204669.Acid345_4590	1.451e-138	445.0	COG1741@1|root,COG1741@2|Bacteria,3Y367@57723|Acidobacteria,2JKXN@204432|Acidobacteriia	204432|Acidobacteriia	S	Pirin C-terminal cupin domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
WZS1_k127_3721035_6	665571.STHERM_c02880	1.395e-43	178.0	2CB4X@1|root,33R8E@2|Bacteria,2J66H@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3721035_2	744872.Spica_0812	2.346e-99	334.0	COG5608@1|root,COG5608@2|Bacteria,2J9FY@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late embryogenesis abundant protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
WZS1_k127_3721035_3	889378.Spiaf_2312	9.096e-99	340.0	COG0577@1|root,COG0577@2|Bacteria,2J66A@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WZS1_k127_3721035_4	290397.Adeh_4155	1.344e-85	290.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42YCW@68525|delta/epsilon subdivisions,2WURX@28221|Deltaproteobacteria,2Z2YA@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_3721035_7	743525.TSC_c02600	9.539e-34	145.0	COG0845@1|root,COG0845@2|Bacteria,1WJ9T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
WZS1_k127_3723265_0	1123274.KB899442_gene891	0.0	1238.0	COG1361@1|root,COG3210@1|root,COG3386@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG4625@2|Bacteria,2J65H@203691|Spirochaetes	203691|Spirochaetes	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_372592_7	1123242.JH636434_gene4390	2.246e-41	154.0	COG0626@1|root,COG0626@2|Bacteria,2IYKV@203682|Planctomycetes	203682|Planctomycetes	E	Cys Met metabolism	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
WZS1_k127_372592_9	331678.Cphamn1_1844	5.24e-18	90.0	COG1648@1|root,COG1648@2|Bacteria,1FF2J@1090|Chlorobi	1090|Chlorobi	H	Putative NAD(P)-binding	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7
WZS1_k127_372592_0	203119.Cthe_2537	9.239e-188	603.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1TQXK@1239|Firmicutes,25EK3@186801|Clostridia,3WISI@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D3
WZS1_k127_372592_1	1195236.CTER_3123	5.182e-162	514.0	COG0175@1|root,COG0175@2|Bacteria,1U1VN@1239|Firmicutes,248Y9@186801|Clostridia,3WJJK@541000|Ruminococcaceae	186801|Clostridia	EH	PFAM Phosphoadenosine phosphosulfate reductase	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
WZS1_k127_372592_5	1123326.JFBL01000018_gene2379	4.725e-74	257.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,42PUJ@68525|delta/epsilon subdivisions,2YN9G@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
WZS1_k127_372592_4	756272.Plabr_4625	7.683e-82	282.0	COG0564@1|root,COG1054@1|root,COG0564@2|Bacteria,COG1054@2|Bacteria,2IXUB@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the UPF0176 family	-	-	-	ko:K07146	-	-	-	-	ko00000	-	-	-	PseudoU_synth_2,Rhodanese
WZS1_k127_372592_2	1123274.KB899410_gene3391	1.45e-89	313.0	2CAZD@1|root,342TQ@2|Bacteria,2J9GV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_372592_8	665571.STHERM_c02890	1.428e-39	155.0	2AMN9@1|root,33WHF@2|Bacteria,2J7R4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_372592_3	665571.STHERM_c02880	7.137e-85	299.0	2CB4X@1|root,33R8E@2|Bacteria,2J66H@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_372592_6	665571.STHERM_c05940	4.83e-57	207.0	COG0787@1|root,COG0787@2|Bacteria,2J5JY@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
WZS1_k127_3729188_1	1480694.DC28_03695	1.388e-191	607.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
WZS1_k127_3729188_3	1307761.L21SP2_2616	9.317e-66	231.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	fpr	GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002	FAD_binding_6,NAD_binding_1
WZS1_k127_3729188_6	665571.STHERM_c14190	8.698e-28	122.0	COG1309@1|root,COG1309@2|Bacteria,2J95Q@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
WZS1_k127_3729188_0	665571.STHERM_c14200	6.818e-215	697.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
WZS1_k127_3729188_5	545694.TREPR_2827	4.709e-50	187.0	COG3026@1|root,COG3026@2|Bacteria,2J6AT@203691|Spirochaetes	203691|Spirochaetes	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
WZS1_k127_3729188_4	158190.SpiGrapes_0143	1.609e-51	202.0	2E2R6@1|root,32XTS@2|Bacteria,2J5DJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3729188_2	869209.Tresu_1525	3.699e-98	327.0	COG2256@1|root,COG2256@2|Bacteria,2J604@203691|Spirochaetes	203691|Spirochaetes	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
WZS1_k127_3730845_3	1123274.KB899410_gene3462	1.324e-70	247.0	COG0457@1|root,COG0457@2|Bacteria,2J5RJ@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
WZS1_k127_3730845_5	573413.Spirs_3826	3.646e-18	98.0	COG1652@1|root,COG1652@2|Bacteria,2J6RK@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70,LysM
WZS1_k127_3730845_4	906968.Trebr_2382	5.237e-53	211.0	COG0741@1|root,COG0741@2|Bacteria,2J7A5@203691|Spirochaetes	203691|Spirochaetes	M	transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_6
WZS1_k127_3730845_0	1123274.KB899410_gene3466	1.103e-220	710.0	COG1674@1|root,COG1674@2|Bacteria,2J63D@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
WZS1_k127_3730845_2	765420.OSCT_2325	1.903e-72	258.0	2C8CV@1|root,2Z8NV@2|Bacteria,2GB29@200795|Chloroflexi,376SN@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF3095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3095
WZS1_k127_3730845_1	665571.STHERM_c03300	1.542e-73	264.0	COG3391@1|root,COG3391@2|Bacteria,2J5ZD@203691|Spirochaetes	203691|Spirochaetes	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
WZS1_k127_3732605_0	1123274.KB899430_gene1682	6.005e-296	923.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
WZS1_k127_3732605_3	1536774.H70357_26115	3.748e-66	234.0	COG0500@1|root,COG2226@2|Bacteria,1UIRD@1239|Firmicutes,4HIXX@91061|Bacilli,274IF@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
WZS1_k127_3732605_5	1123274.KB899407_gene400	4.403e-41	158.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	yisX	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
WZS1_k127_3732605_8	1121861.KB899922_gene3196	3.503e-10	66.0	2DZGT@1|root,32VA7@2|Bacteria,1N101@1224|Proteobacteria,2UEKZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3732605_4	223283.PSPTO_0930	4.138e-46	174.0	COG2442@1|root,COG2442@2|Bacteria,1REK1@1224|Proteobacteria,1S4WC@1236|Gammaproteobacteria,1Z9P1@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
WZS1_k127_3732605_6	1539298.JO41_06445	1.855e-40	154.0	COG0629@1|root,COG0629@2|Bacteria,2J86A@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
WZS1_k127_3732605_1	665571.STHERM_c01780	4.584e-160	512.0	COG0115@1|root,COG0115@2|Bacteria,2J6WR@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
WZS1_k127_3732605_2	889378.Spiaf_0675	5.836e-93	340.0	COG0457@1|root,COG0457@2|Bacteria,2J5XG@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
WZS1_k127_3732605_7	889378.Spiaf_0674	1.268e-37	151.0	COG0296@1|root,COG0296@2|Bacteria,2J5AV@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
WZS1_k127_3732605_9	1480694.DC28_10150	2.574e-07	57.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
WZS1_k127_3740916_0	1480694.DC28_04080	1.835e-210	723.0	COG0841@1|root,COG3420@1|root,COG0841@2|Bacteria,COG3420@2|Bacteria,2J58E@203691|Spirochaetes	203691|Spirochaetes	P	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
WZS1_k127_3747397_3	1480694.DC28_13390	6.359e-144	469.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WZS1_k127_3747397_4	177437.HRM2_11210	2.667e-74	260.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,42Q9R@68525|delta/epsilon subdivisions,2WKU4@28221|Deltaproteobacteria,2MIVX@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
WZS1_k127_3747397_5	1123274.KB899410_gene3485	3.464e-51	190.0	COG0204@1|root,COG0204@2|Bacteria,2J7RR@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
WZS1_k127_3747397_0	573413.Spirs_4004	4.629e-279	868.0	COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes	203691|Spirochaetes	L	DNA topoisomerase	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
WZS1_k127_3747397_1	1480694.DC28_14615	9.775e-257	807.0	COG0188@1|root,COG0188@2|Bacteria,2J5Y9@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the type II topoisomerase GyrA ParC subunit family	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
WZS1_k127_3747397_6	1123274.KB899408_gene3855	8.523e-38	154.0	COG2940@1|root,COG2940@2|Bacteria	2|Bacteria	K	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
WZS1_k127_3747397_2	744872.Spica_1720	2.188e-153	495.0	COG1233@1|root,COG1233@2|Bacteria,2J5I9@203691|Spirochaetes	203691|Spirochaetes	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,1.3.99.37	ko:K10027,ko:K20611	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
WZS1_k127_375564_0	1196323.ALKF01000138_gene3469	1.004e-128	418.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_375564_1	1196323.ALKF01000138_gene3468	6.127e-55	209.0	COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_3758233_1	29730.Gorai.001G162300.1	5.123e-16	80.0	COG2801@1|root,KOG0017@2759|Eukaryota,37TAQ@33090|Viridiplantae,3GDDG@35493|Streptophyta	35493|Streptophyta	L	cellular component organization	ccmFc	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	-	-	-	-	-	-	-	-	-	-	CcmF_C
WZS1_k127_3758233_0	3847.GLYMA18G17565.1	2.503e-18	85.0	COG0740@1|root,KOG0840@2759|Eukaryota	2759|Eukaryota	OU	serine-type endopeptidase activity	-	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	CLP_protease
WZS1_k127_3758233_3	3702.ATCG01230.1	6.978e-06	48.0	COG0048@1|root,KOG1750@2759|Eukaryota,37VNW@33090|Viridiplantae,3GJJI@35493|Streptophyta	35493|Streptophyta	J	Belongs to the universal ribosomal protein uS12 family	rps12-A	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009534,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0010467,GO:0019538,GO:0031976,GO:0031984,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WZS1_k127_3768730_3	263820.PTO0507	0.0001496	44.0	COG2151@1|root,arCOG01845@2157|Archaea,2Y0P6@28890|Euryarchaeota,242AR@183967|Thermoplasmata	183967|Thermoplasmata	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
WZS1_k127_3768730_1	744872.Spica_0326	4.168e-52	192.0	COG2249@1|root,COG2249@2|Bacteria,2J8WQ@203691|Spirochaetes	203691|Spirochaetes	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
WZS1_k127_3768730_0	1307761.L21SP2_2400	2.058e-234	737.0	COG0119@1|root,COG0119@2|Bacteria,2J5UF@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
WZS1_k127_3768730_2	1480694.DC28_01295	6.318e-28	115.0	COG0533@1|root,COG0533@2|Bacteria,2J5WG@203691|Spirochaetes	203691|Spirochaetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WZS1_k127_3776377_0	684949.ATTJ01000001_gene2296	1.636e-10	74.0	COG2373@1|root,COG3828@1|root,COG2373@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,CarboxypepD_reg,DUF11,Metallophos,VCBS
WZS1_k127_3776720_0	665571.STHERM_c18040	7.425e-94	314.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	scrK	-	2.7.1.2,2.7.1.4	ko:K00845,ko:K00847	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
WZS1_k127_3821903_4	1307761.L21SP2_3454	2.876e-53	195.0	COG0009@1|root,COG0009@2|Bacteria,2J7IA@203691|Spirochaetes	203691|Spirochaetes	J	Telomere recombination	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
WZS1_k127_3821903_7	573413.Spirs_3055	2.419e-12	68.0	2EH2E@1|root,32KRT@2|Bacteria,2J916@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3821903_0	1121097.JCM15093_1900	3.399e-85	292.0	COG0053@1|root,COG0053@2|Bacteria,4NFBB@976|Bacteroidetes,2G36X@200643|Bacteroidia,4AWAU@815|Bacteroidaceae	976|Bacteroidetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
WZS1_k127_3821903_3	889378.Spiaf_2020	6.631e-54	204.0	COG0457@1|root,COG0457@2|Bacteria,2J6MJ@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
WZS1_k127_3821903_1	545695.TREAZ_0286	8.784e-58	213.0	COG0564@1|root,COG0564@2|Bacteria,2J7HP@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the pseudouridine synthase RluA family	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WZS1_k127_3821903_8	1254432.SCE1572_22275	4.406e-10	70.0	COG1463@1|root,COG1463@2|Bacteria,1QTED@1224|Proteobacteria,437WX@68525|delta/epsilon subdivisions,2WWP6@28221|Deltaproteobacteria,2YVFU@29|Myxococcales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
WZS1_k127_3821903_2	768670.Calni_0909	2.649e-55	205.0	COG1127@1|root,COG1127@2|Bacteria,2GEYW@200930|Deferribacteres	200930|Deferribacteres	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
WZS1_k127_3821903_6	673862.BABL1_229	1.984e-26	119.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
WZS1_k127_3821903_5	1480694.DC28_14730	3.432e-43	164.0	COG1963@1|root,COG1963@2|Bacteria,2J7WX@203691|Spirochaetes	203691|Spirochaetes	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
WZS1_k127_3822506_1	886293.Sinac_7017	2.084e-43	173.0	29WNZ@1|root,30I9V@2|Bacteria,2IYJI@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3822506_0	1121904.ARBP01000018_gene2631	5.896e-116	403.0	COG2203@1|root,COG2203@2|Bacteria,4NE84@976|Bacteroidetes,47K2E@768503|Cytophagia	976|Bacteroidetes	T	Gaf domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3822506_2	1121859.KB890754_gene805	3.224e-19	101.0	COG0457@1|root,COG0642@1|root,COG0457@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,HisKA_7TM,Hpt,PAS_4,PAS_9,Response_reg,TPR_12
WZS1_k127_3822625_0	1307761.L21SP2_2608	8.079e-263	836.0	COG2352@1|root,COG2352@2|Bacteria	2|Bacteria	C	phosphoenolpyruvate carboxylase activity	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
WZS1_k127_3822625_5	1123277.KB893173_gene1500	6.048e-22	103.0	2A5JD@1|root,30U9Q@2|Bacteria,4NRNK@976|Bacteroidetes,47Q7S@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3822625_3	1307761.L21SP2_0473	1.018e-70	271.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_3822625_2	889378.Spiaf_1330	1.312e-135	454.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
WZS1_k127_3822625_1	889378.Spiaf_1331	1.468e-140	460.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	thuE	-	-	ko:K02027,ko:K10236	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
WZS1_k127_3822625_4	945543.VIBR0546_08842	4.328e-23	100.0	COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,1NC9X@1224|Proteobacteria,1T1YW@1236|Gammaproteobacteria,1Y337@135623|Vibrionales	135623|Vibrionales	T	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	GO:0000156,GO:0000160,GO:0003674,GO:0003824,GO:0004112,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009187,GO:0009214,GO:0009987,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0023052,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035556,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055086,GO:0060089,GO:0065007,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	DUF3369,HD,HD_5,Response_reg
WZS1_k127_3829724_2	177437.HRM2_06320	8.76e-55	196.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2MIER@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
WZS1_k127_3829724_0	177437.HRM2_06330	1.835e-130	428.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42QQQ@68525|delta/epsilon subdivisions,2WMBP@28221|Deltaproteobacteria,2MIM7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WZS1_k127_3829724_1	177437.HRM2_06340	1.825e-84	289.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,42P6E@68525|delta/epsilon subdivisions,2WISH@28221|Deltaproteobacteria,2MHMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WZS1_k127_383203_0	1123274.KB899415_gene2406	3.769e-59	218.0	COG1706@1|root,COG1706@2|Bacteria,2JARZ@203691|Spirochaetes	203691|Spirochaetes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
WZS1_k127_3835072_1	889378.Spiaf_0869	1.749e-14	75.0	COG1484@1|root,COG1484@2|Bacteria,2J7ZC@203691|Spirochaetes	203691|Spirochaetes	L	PFAM IstB-like ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
WZS1_k127_3835072_0	1122929.KB908219_gene1787	7.926e-160	512.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
WZS1_k127_3850568_7	189425.PGRAT_26210	3.102e-31	133.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
WZS1_k127_3850568_1	1211114.ALIP01000072_gene1645	2.931e-94	312.0	COG0605@1|root,COG0605@2|Bacteria,1MV24@1224|Proteobacteria,1SZW5@1236|Gammaproteobacteria,1X5VQ@135614|Xanthomonadales	135614|Xanthomonadales	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodM	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
WZS1_k127_3850568_0	1480694.DC28_06800	5.891e-104	343.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_3850568_3	158190.SpiGrapes_2916	4.103e-83	294.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
WZS1_k127_3850568_2	158190.SpiGrapes_2917	3.263e-83	293.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WZS1_k127_3850568_5	158190.SpiGrapes_2918	1.961e-69	245.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
WZS1_k127_3850568_6	1480694.DC28_06820	1.394e-36	154.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3850568_4	158190.SpiGrapes_2920	8.888e-73	252.0	COG0745@1|root,COG0745@2|Bacteria,2J7CF@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
WZS1_k127_3862875_2	56780.SYN_00964	8.588e-20	92.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2MQXG@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	CheB methylesterase	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
WZS1_k127_3862875_1	1123503.KB908056_gene1800	3.119e-37	150.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,2KGC1@204458|Caulobacterales	204458|Caulobacterales	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
WZS1_k127_3862875_0	1196322.A370_01520	4.364e-74	270.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,24YSF@186801|Clostridia,36Q8U@31979|Clostridiaceae	186801|Clostridia	NT	Tar ligand binding domain homologue	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
WZS1_k127_3865660_0	1391647.AVSV01000022_gene2612	4.506e-07	60.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,36DH6@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
WZS1_k127_3869582_2	3750.XP_008387688.1	0.0005817	44.0	KOG4658@1|root,KOG4658@2759|Eukaryota,37SXH@33090|Viridiplantae,3GAM1@35493|Streptophyta	35493|Streptophyta	T	disease resistance	-	-	-	ko:K15078,ko:K19613	ko03460,ko04014,map03460,map04014	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	NB-ARC
WZS1_k127_3869582_0	4558.Sb03g023051.1	1.234e-06	53.0	COG2801@1|root,KOG0017@2759|Eukaryota,37XFT@33090|Viridiplantae,3GNEX@35493|Streptophyta,3MB5I@4447|Liliopsida,3IUQS@38820|Poales	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Retrotrans_gag
WZS1_k127_3869582_1	57918.XP_004296867.1	3.356e-06	49.0	28HJJ@1|root,2QSEB@2759|Eukaryota,37SK8@33090|Viridiplantae,3GF4Q@35493|Streptophyta,4JMEI@91835|fabids	35493|Streptophyta	S	protein At3g15000, mitochondrial-like	-	GO:0000959,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0016071,GO:0016556,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:0080156,GO:0090304,GO:1900864,GO:1901360	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_386997_2	665571.STHERM_c00960	1.233e-37	153.0	COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,2J6UE@203691|Spirochaetes	203691|Spirochaetes	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig
WZS1_k127_386997_0	744872.Spica_0341	1.679e-73	257.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J5FR@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
WZS1_k127_386997_1	926692.AZYG01000079_gene381	4.013e-52	198.0	COG2365@1|root,COG2365@2|Bacteria,1TRAZ@1239|Firmicutes,2491G@186801|Clostridia	186801|Clostridia	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	SAM_adeno_trans,Y_phosphatase3
WZS1_k127_3879124_8	981085.XP_010094473.1	2.998e-06	49.0	COG0049@1|root,KOG3291@2759|Eukaryota,37JZ5@33090|Viridiplantae,3GGCG@35493|Streptophyta,4JQAD@91835|fabids	35493|Streptophyta	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit	rps7-A	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23,Ribosomal_S7
WZS1_k127_3879124_5	3880.AES58512	5.82e-11	64.0	2EXY6@1|root,2SZI6@2759|Eukaryota,3825S@33090|Viridiplantae,3GR6C@35493|Streptophyta	3880.AES58512|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3879124_1	981085.XP_010096190.1	1.323e-66	231.0	COG0090@1|root,KOG0438@2759|Eukaryota,38AJK@33090|Viridiplantae,3GSK2@35493|Streptophyta,4JUXX@91835|fabids	35493|Streptophyta	J	structural constituent of ribosome	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3879124_11	4565.Traes_7DS_77EDD797A.1	3.593e-05	53.0	2CDXT@1|root,2S1NU@2759|Eukaryota,37VRF@33090|Viridiplantae,3GJAF@35493|Streptophyta,3M0B1@4447|Liliopsida,3II7X@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3879124_6	265311.Mfl394	7.165e-10	60.0	COG0275@1|root,COG0275@2|Bacteria,3WT1M@544448|Tenericutes	544448|Tenericutes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	mraW	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
WZS1_k127_3879124_0	29760.VIT_01s0146g00390.t01	2.563e-80	272.0	29XCM@1|root,2RXRI@2759|Eukaryota,37U8V@33090|Viridiplantae,3GHWM@35493|Streptophyta	35493|Streptophyta	S	ATP synthase protein YMF19	-	GO:0000276,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0005773,GO:0009507,GO:0009536,GO:0016020,GO:0016469,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0033177,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045259,GO:0045263,GO:0046872,GO:0046914,GO:0050897,GO:0098796,GO:0098798,GO:0098800	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	DUF1082,YMF19
WZS1_k127_3879124_9	4558.Sb08g017445.1	8.618e-06	52.0	KOG1075@1|root,KOG1075@2759|Eukaryota,38AUR@33090|Viridiplantae,3GZRQ@35493|Streptophyta,3MACM@4447|Liliopsida,3IT75@38820|Poales	35493|Streptophyta	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3879124_7	4533.OB12G21250.1	8.977e-07	53.0	COG0515@1|root,2QSJ4@2759|Eukaryota,37JWA@33090|Viridiplantae,3GAQ6@35493|Streptophyta,3KUR4@4447|Liliopsida,3IB38@38820|Poales	35493|Streptophyta	T	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Lectin_legB,Pkinase,Pkinase_Tyr
WZS1_k127_3879124_10	3750.XP_008385055.1	9.181e-06	51.0	COG2801@1|root,KOG0017@2759|Eukaryota	3750.XP_008385055.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3885027_8	545694.TREPR_1194	1.588e-36	147.0	COG1426@1|root,COG1426@2|Bacteria,2J61E@203691|Spirochaetes	203691|Spirochaetes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
WZS1_k127_3885027_7	545695.TREAZ_2740	1.124e-50	188.0	COG2834@1|root,COG2834@2|Bacteria,2J7JX@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
WZS1_k127_3885027_4	573413.Spirs_3761	9.284e-115	400.0	COG0457@1|root,COG0457@2|Bacteria,2J6MS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
WZS1_k127_3885027_5	243275.TDE_2085	7.523e-89	299.0	COG0528@1|root,COG0528@2|Bacteria,2J5H9@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
WZS1_k127_3885027_10	1432056.X781_19880	8.419e-11	73.0	2CS41@1|root,32SQ9@2|Bacteria,1MZEU@1224|Proteobacteria,1SA5D@1236|Gammaproteobacteria,1Y8MT@135625|Pasteurellales	135625|Pasteurellales	S	Protein of unknown function (DUF3298)	Z012_04555	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
WZS1_k127_3885027_0	1123274.KB899409_gene494	1.614e-202	651.0	COG3707@1|root,COG5001@1|root,COG3707@2|Bacteria,COG5001@2|Bacteria,2JBHK@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,Response_reg,dCache_1
WZS1_k127_3885027_2	1307761.L21SP2_2867	2.109e-156	506.0	COG0114@1|root,COG0114@2|Bacteria,2JBKJ@203691|Spirochaetes	203691|Spirochaetes	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
WZS1_k127_3885027_1	889378.Spiaf_2857	6.79e-180	571.0	COG0082@1|root,COG0082@2|Bacteria,2J5CX@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
WZS1_k127_3885027_6	1480694.DC28_10280	1.127e-80	281.0	COG3712@1|root,COG3712@2|Bacteria,2J9H5@203691|Spirochaetes	203691|Spirochaetes	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
WZS1_k127_3885027_9	889378.Spiaf_0494	5.801e-12	78.0	COG1652@1|root,COG1652@2|Bacteria,2J7QX@203691|Spirochaetes	203691|Spirochaetes	S	Treponemal membrane protein	tmpB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LysM
WZS1_k127_3885027_3	1480694.DC28_10275	2.97e-121	404.0	COG0460@1|root,COG0460@2|Bacteria,2J89J@203691|Spirochaetes	203691|Spirochaetes	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
WZS1_k127_3889635_8	1380370.JIBA01000012_gene3754	1.803e-20	97.0	2DX9W@1|root,3441U@2|Bacteria	2|Bacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
WZS1_k127_3889635_1	1487923.DP73_19335	1.192e-127	415.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,24BVW@186801|Clostridia,263MB@186807|Peptococcaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
WZS1_k127_3889635_4	555779.Dthio_PD1036	1.29e-63	231.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
WZS1_k127_3889635_2	545694.TREPR_1664	6.269e-108	374.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
WZS1_k127_3889635_10	546414.Deide_15510	1.089e-10	66.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_3,Cupredoxin_1
WZS1_k127_3889635_11	1519439.JPJG01000014_gene119	8.437e-10	69.0	COG0789@1|root,COG0789@2|Bacteria,1TPUE@1239|Firmicutes,24AS8@186801|Clostridia,2N7P7@216572|Oscillospiraceae	186801|Clostridia	K	helix_turn_helix, mercury resistance	bltR	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
WZS1_k127_3889635_12	661367.LLO_1534	7.491e-08	64.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1JDHY@118969|Legionellales	118969|Legionellales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
WZS1_k127_3889635_3	889378.Spiaf_0762	3.591e-79	277.0	COG0297@1|root,COG0297@2|Bacteria,2J9RH@203691|Spirochaetes	203691|Spirochaetes	G	glycogen (starch) synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_5
WZS1_k127_3889635_0	243275.TDE_0719	1.963e-172	566.0	COG2274@1|root,COG2274@2|Bacteria,2J641@203691|Spirochaetes	203691|Spirochaetes	V	Bacteriocin ABC transporter, ATP-binding permease	-	-	-	ko:K06147,ko:K20344	ko02010,ko02024,map02010,map02024	-	-	-	ko00000,ko00001,ko02000	3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
WZS1_k127_3889635_5	906968.Trebr_1062	2.179e-32	140.0	COG0845@1|root,COG0845@2|Bacteria,2J6XE@203691|Spirochaetes	203691|Spirochaetes	M	HlyD family secretion protein	-	-	-	ko:K20345	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	3.A.1.112,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3
WZS1_k127_3889635_9	232346.JHQL01000004_gene1640	1.691e-12	73.0	2DPXP@1|root,333U7@2|Bacteria,1N6PZ@1224|Proteobacteria,1SRDJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3889635_6	1120999.JONM01000001_gene1282	6.134e-31	134.0	COG0457@1|root,COG4676@1|root,COG0457@2|Bacteria,COG4676@2|Bacteria,1QZ6W@1224|Proteobacteria,2VKUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135,VIT
WZS1_k127_3905251_0	1307761.L21SP2_2817	2.646e-179	569.0	COG2873@1|root,COG2873@2|Bacteria,2J5MU@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Cys Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
WZS1_k127_3905251_1	665571.STHERM_c12900	4.541e-127	413.0	COG0031@1|root,COG0031@2|Bacteria,2J5EE@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WZS1_k127_3905251_2	744872.Spica_0276	5.869e-94	322.0	COG2885@1|root,COG2885@2|Bacteria,2J6IG@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	tpn50	-	-	-	-	-	-	-	-	-	-	-	OmpA
WZS1_k127_3905251_7	573413.Spirs_0468	2.093e-32	132.0	COG0513@1|root,COG0724@1|root,COG0513@2|Bacteria,COG0724@2|Bacteria,2J7A1@203691|Spirochaetes	203691|Spirochaetes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA
WZS1_k127_3905251_4	1123274.KB899408_gene3788	1.705e-41	168.0	2FEHN@1|root,346H5@2|Bacteria,2J8A9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3905251_8	545694.TREPR_3049	1.323e-13	76.0	28WTD@1|root,2ZISW@2|Bacteria,2J93F@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_3905251_5	573413.Spirs_0464	7.616e-40	150.0	COG1734@1|root,COG1734@2|Bacteria,2J7Y1@203691|Spirochaetes	203691|Spirochaetes	T	Prokaryotic dksA traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
WZS1_k127_3905251_6	1123274.KB899408_gene3784	6.819e-35	134.0	COG0361@1|root,COG0361@2|Bacteria,2J8JW@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
WZS1_k127_3905251_9	1125699.HMPREF9194_00375	6.079e-12	70.0	COG2840@1|root,COG2840@2|Bacteria,2J57A@203691|Spirochaetes	203691|Spirochaetes	S	Smr domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Smr
WZS1_k127_3905251_3	1123274.KB899408_gene3782	5.21e-43	179.0	COG0457@1|root,COG0457@2|Bacteria,2JBKA@203691|Spirochaetes	203691|Spirochaetes	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
WZS1_k127_3945434_2	764291.STRUR_2191	0.0001221	50.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
WZS1_k127_3945434_1	373994.Riv7116_6096	5.451e-14	74.0	2BX0X@1|root,306UX@2|Bacteria,1GI5W@1117|Cyanobacteria,1HT0Z@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	-
WZS1_k127_3945434_0	102232.GLO73106DRAFT_00006800	2.474e-30	121.0	COG4115@1|root,COG4115@2|Bacteria,1G82H@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM Addiction module toxin, Txe YoeB	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YoeB_toxin
WZS1_k127_394586_0	1028800.RG540_CH17780	3.651e-16	78.0	COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2VG87@28211|Alphaproteobacteria,4BNHK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
WZS1_k127_396_3	71139.XP_010068878.1	1.31e-18	86.0	COG2801@1|root,KOG0017@2759|Eukaryota,37R6P@33090|Viridiplantae	33090|Viridiplantae	E	Uncharacterized protein K02A2.6-like	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	G-patch,RVT_1,RVT_3,Retrotrans_gag,rve
WZS1_k127_396_14	4113.PGSC0003DMT400021489	6.154e-09	58.0	COG2009@1|root,KOG0449@2759|Eukaryota,37WX8@33090|Viridiplantae,3GKZI@35493|Streptophyta,44TH9@71274|asterids	35493|Streptophyta	G	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdh3	GO:0005575,GO:0005622,GO:0005623,GO:0016020,GO:0032991,GO:0044424,GO:0044425,GO:0044464,GO:0045273,GO:0070469,GO:0098796,GO:0098803	-	ko:K00236	ko00020,ko00190,ko01100,ko01110,ko01120,ko01130,ko01200,ko04714,ko04932,ko05010,ko05012,ko05016,map00020,map00190,map01100,map01110,map01120,map01130,map01200,map04714,map04932,map05010,map05012,map05016	M00009,M00011,M00148	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	HSP70,Sdh_cyt
WZS1_k127_396_5	3880.AES58568	2.87e-17	81.0	28VD5@1|root,2R24N@2759|Eukaryota,38A1H@33090|Viridiplantae,3GR50@35493|Streptophyta	3880.AES58568|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_15	3988.XP_002535856.1	9.04e-09	56.0	2EAFF@1|root,2SGPE@2759|Eukaryota,37XN0@33090|Viridiplantae,3GMKE@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_9	3988.XP_002535856.1	8.21e-14	74.0	2EAFF@1|root,2SGPE@2759|Eukaryota,37XN0@33090|Viridiplantae,3GMKE@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_12	3880.AES58545	7.614e-10	65.0	2E724@1|root,2SDQ0@2759|Eukaryota,37XK8@33090|Viridiplantae,3GMV1@35493|Streptophyta	3880.AES58545|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_11	3880.AES58569	7.156e-10	62.0	2E724@1|root,2SDQ0@2759|Eukaryota,37XK8@33090|Viridiplantae,3GMV1@35493|Streptophyta	3880.AES58569|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_10	3880.AES58569	4.511e-11	64.0	2E724@1|root,2SDQ0@2759|Eukaryota,37XK8@33090|Viridiplantae,3GMV1@35493|Streptophyta	3880.AES58569|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_24	3880.AES58569	0.0001134	46.0	2E724@1|root,2SDQ0@2759|Eukaryota,37XK8@33090|Viridiplantae,3GMV1@35493|Streptophyta	3880.AES58569|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_7	3847.GLYMA0973S200.1	6.654e-17	81.0	2EZXM@1|root,2T167@2759|Eukaryota,3823B@33090|Viridiplantae,3GS09@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_23	4155.Migut.O00425.1.p	1.036e-05	48.0	2C618@1|root,2SZ5S@2759|Eukaryota,382UG@33090|Viridiplantae,3GS30@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_25	29760.VIT_00s0332g00070.t01	0.0004185	44.0	2EZXM@1|root,2T167@2759|Eukaryota,3823B@33090|Viridiplantae,3GS09@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_396_16	4096.XP_009776361.1	1.234e-07	56.0	2E1M0@1|root,2S8XN@2759|Eukaryota,37WG5@33090|Viridiplantae,3GK4P@35493|Streptophyta	35493|Streptophyta	S	Plant mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PMD
WZS1_k127_396_4	4096.XP_009760845.1	2.559e-17	91.0	2E1M0@1|root,2S8XN@2759|Eukaryota,37X9X@33090|Viridiplantae,3GMED@35493|Streptophyta,44MZF@71274|asterids	35493|Streptophyta	S	Plant mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PMD
WZS1_k127_396_19	3659.XP_004148824.1	8.507e-07	51.0	COG0515@1|root,KOG1187@2759|Eukaryota,37PSM@33090|Viridiplantae,3GCKH@35493|Streptophyta,4JKI2@91835|fabids	35493|Streptophyta	T	L-type lectin-domain containing receptor kinase	-	GO:0002229,GO:0002239,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0016020,GO:0042742,GO:0043207,GO:0044464,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098542	2.7.11.1	ko:K04733	ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Lectin_legB,Pkinase,Pkinase_Tyr
WZS1_k127_40204_2	717606.PaecuDRAFT_0981	1.849e-34	143.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
WZS1_k127_40204_1	390874.Tpet_0517	4.26e-41	154.0	COG0347@1|root,COG0347@2|Bacteria	2|Bacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
WZS1_k127_40204_0	1499967.BAYZ01000119_gene3219	8.314e-189	599.0	COG0004@1|root,COG0004@2|Bacteria,2NP8F@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
WZS1_k127_4038574_0	545694.TREPR_1396	6.364e-106	351.0	COG2804@1|root,COG2804@2|Bacteria,2J5A6@203691|Spirochaetes	203691|Spirochaetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE
WZS1_k127_4038574_1	1123274.KB899436_gene1289	4.236e-16	89.0	COG1459@1|root,COG1459@2|Bacteria,2J7Y9@203691|Spirochaetes	203691|Spirochaetes	U	Bacterial type II secretion system protein F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
WZS1_k127_4058083_9	4098.XP_009610589.1	2.361e-10	63.0	COG2801@1|root,KOG0017@2759|Eukaryota	4098.XP_009610589.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4058083_12	4538.ORGLA01G0105200.1	3.135e-08	55.0	COG2801@1|root,KOG0017@2759|Eukaryota,37YYP@33090|Viridiplantae,3GQD7@35493|Streptophyta,3M3FD@4447|Liliopsida,3IKKZ@38820|Poales	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
WZS1_k127_4058083_6	85681.XP_006434427.1	7.39e-16	78.0	COG0515@1|root,KOG1187@2759|Eukaryota,37PSM@33090|Viridiplantae,3GCKH@35493|Streptophyta	35493|Streptophyta	T	L-type lectin-domain containing receptor kinase	-	GO:0002229,GO:0002239,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0016020,GO:0042742,GO:0043207,GO:0044464,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098542	2.7.11.1	ko:K04733	ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Lectin_legB,Pkinase,Pkinase_Tyr
WZS1_k127_4058083_8	3641.EOY16665	3.608e-13	69.0	COG0515@1|root,KOG1187@2759|Eukaryota,37PSM@33090|Viridiplantae,3GCKH@35493|Streptophyta	35493|Streptophyta	T	L-type lectin-domain containing receptor kinase	-	GO:0002229,GO:0002239,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0016020,GO:0042742,GO:0043207,GO:0044464,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098542	2.7.11.1	ko:K04733	ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Lectin_legB,Pkinase,Pkinase_Tyr
WZS1_k127_4058083_1	981085.XP_010102091.1	1.256e-44	169.0	COG0515@1|root,KOG1187@2759|Eukaryota,37PSM@33090|Viridiplantae,3GCKH@35493|Streptophyta,4JKI2@91835|fabids	35493|Streptophyta	T	L-type lectin-domain containing receptor kinase	-	GO:0002229,GO:0002239,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0016020,GO:0042742,GO:0043207,GO:0044464,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098542	2.7.11.1	ko:K04733	ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Lectin_legB,Pkinase,Pkinase_Tyr
WZS1_k127_4058083_2	3880.AES58603	2.434e-33	129.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta,4JT2P@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_4058083_11	4577.GRMZM2G028745_P01	1.81e-08	55.0	2CHT3@1|root,2R55W@2759|Eukaryota,38605@33090|Viridiplantae,3GTXX@35493|Streptophyta,3M80Q@4447|Liliopsida,3ISAH@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4058083_14	29730.Gorai.001G164600.1	8.055e-05	46.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta	35493|Streptophyta	C	ATP synthesis coupled electron transport	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_4058083_13	3880.AES58603	2.514e-07	55.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta,4JT2P@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_4058083_10	3711.Bra023423.1-P	2.753e-10	61.0	28KHE@1|root,2QR2D@2759|Eukaryota,37I4V@33090|Viridiplantae,3GD84@35493|Streptophyta	35493|Streptophyta	S	Belongs to the NPH3 family	-	GO:0005575,GO:0016020	-	-	-	-	-	-	-	-	-	-	BTB,NPH3
WZS1_k127_4058083_3	4572.TRIUR3_02620-P1	5.87e-24	103.0	2CCPB@1|root,2R7NX@2759|Eukaryota,3880F@33090|Viridiplantae,3GZ00@35493|Streptophyta,3KU9D@4447|Liliopsida,3IC7T@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4058083_5	218851.Aquca_023_00080.1	2.279e-16	78.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta	35493|Streptophyta	C	ATP synthesis coupled electron transport	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_4058083_0	3659.XP_004153848.1	7.49e-154	488.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta,4JT2P@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_4058083_4	29730.Gorai.001G164600.1	1.576e-22	98.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta	35493|Streptophyta	C	ATP synthesis coupled electron transport	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_4058908_4	643867.Ftrac_2032	2.823e-05	53.0	2EBC4@1|root,335CV@2|Bacteria,4P1X4@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyl hydrolase family 53	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_53
WZS1_k127_4058908_3	889378.Spiaf_1165	1.337e-45	190.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_4058908_0	744980.TRICHSKD4_0181	1.344e-137	446.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
WZS1_k127_4058908_1	710686.Mycsm_02960	1.893e-96	336.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,233KE@1762|Mycobacteriaceae	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	GO:0008150,GO:0040007	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1595	FAD_binding_2,Succ_DH_flav_C
WZS1_k127_4058908_2	123899.JPQP01000019_gene2721	2.053e-65	231.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VHSU@28216|Betaproteobacteria,3T2KZ@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
WZS1_k127_408493_4	331678.Cphamn1_1486	2.828e-53	201.0	COG5263@1|root,COG5263@2|Bacteria,1FDG5@1090|Chlorobi	1090|Chlorobi	S	PFAM KWG Leptospira repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
WZS1_k127_408493_8	1051646.VITU9109_09417	4.795e-09	66.0	COG0834@1|root,COG0834@2|Bacteria,1PGMR@1224|Proteobacteria,1T9M4@1236|Gammaproteobacteria,1XWJN@135623|Vibrionales	135623|Vibrionales	ET	COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
WZS1_k127_408493_2	7070.TC009423-PA	2.988e-106	356.0	COG0516@1|root,KOG2550@2759|Eukaryota,38BP6@33154|Opisthokonta,3BAD2@33208|Metazoa,3CRAZ@33213|Bilateria,41U2X@6656|Arthropoda,3SH6Y@50557|Insecta	33208|Metazoa	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	GMPR	GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0003674,GO:0003824,GO:0003920,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006163,GO:0006195,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016491,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030097,GO:0030099,GO:0030154,GO:0030224,GO:0032501,GO:0032502,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046038,GO:0046128,GO:0046130,GO:0046434,GO:0046483,GO:0046700,GO:0048513,GO:0048534,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1903131	1.7.1.7	ko:K00364	ko00230,map00230	-	R01134	RC00457	ko00000,ko00001,ko01000	-	-	-	IMPDH
WZS1_k127_408493_3	1121382.JQKG01000001_gene2329	2.607e-94	317.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
WZS1_k127_408493_0	118005.AWNK01000006_gene1284	1.031e-174	555.0	COG0798@1|root,COG0798@2|Bacteria	2|Bacteria	P	PFAM Bile acid sodium symporter	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
WZS1_k127_408493_6	357808.RoseRS_1209	3.944e-16	83.0	2EJQK@1|root,33DFE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_408493_1	1403313.AXBR01000010_gene1057	7.679e-159	511.0	COG0477@1|root,COG0477@2|Bacteria,1UHRM@1239|Firmicutes,4ISTP@91061|Bacilli,1ZSG1@1386|Bacillus	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
WZS1_k127_408493_7	643867.Ftrac_2032	5.789e-15	82.0	2EBC4@1|root,335CV@2|Bacteria,4P1X4@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyl hydrolase family 53	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_53
WZS1_k127_4091825_2	573413.Spirs_0297	3.424e-55	199.0	COG0293@1|root,COG0293@2|Bacteria,2J5SK@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
WZS1_k127_4091825_0	545695.TREAZ_2839	7.727e-75	264.0	COG0142@1|root,COG0142@2|Bacteria,2J673@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.30,2.5.1.90	ko:K00805,ko:K02523,ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061,R09247,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
WZS1_k127_4091825_3	573413.Spirs_0298	4.313e-55	199.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
WZS1_k127_4091825_7	1307761.L21SP2_3467	5.217e-28	122.0	2FBC5@1|root,343I0@2|Bacteria,2J6WZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4091825_10	243233.MCA0439	1.078e-06	59.0	COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria,1XFS3@135618|Methylococcales	135618|Methylococcales	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
WZS1_k127_4091825_5	56780.SYN_01425	2.719e-39	168.0	COG4206@1|root,COG4206@2|Bacteria,1QUJF@1224|Proteobacteria,43BJH@68525|delta/epsilon subdivisions,2WM36@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
WZS1_k127_4091825_8	1279009.ADICEAN_00569	1.668e-24	118.0	COG0457@1|root,COG0642@1|root,COG0457@2|Bacteria,COG2205@2|Bacteria,4NI29@976|Bacteroidetes,47KZN@768503|Cytophagia	976|Bacteroidetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,TPR_12,TPR_8
WZS1_k127_4091825_6	215803.DB30_1947	7.235e-39	152.0	2DY29@1|root,32V4J@2|Bacteria,1P2QH@1224|Proteobacteria,43F3S@68525|delta/epsilon subdivisions,2X9U6@28221|Deltaproteobacteria,2YV4T@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4091825_1	1121035.AUCH01000002_gene1590	1.374e-61	221.0	COG0220@1|root,COG0220@2|Bacteria,1RE0G@1224|Proteobacteria,2VQEM@28216|Betaproteobacteria,2KW22@206389|Rhodocyclales	206389|Rhodocyclales	H	Methyltransferase	-	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
WZS1_k127_4091825_4	1304874.JAFY01000007_gene2490	9.684e-53	202.0	COG4251@1|root,COG4936@1|root,COG4251@2|Bacteria,COG4936@2|Bacteria,3TCMP@508458|Synergistetes	2|Bacteria	T	GHKL domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF,GAF_2,GGDEF,HATPase_c,HD,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR
WZS1_k127_4091825_9	330214.NIDE2515	1.077e-09	60.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2,DUF3971,DUF748
WZS1_k127_4095958_3	158189.SpiBuddy_2690	3.103e-18	84.0	COG1233@1|root,COG1233@2|Bacteria,2J5I9@203691|Spirochaetes	203691|Spirochaetes	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,1.3.99.37	ko:K10027,ko:K20611	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
WZS1_k127_4095958_1	1220534.B655_1671	2.341e-84	290.0	COG1562@1|root,arCOG02936@2157|Archaea,2XTG2@28890|Euryarchaeota	28890|Euryarchaeota	I	Phytoene squalene synthetase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
WZS1_k127_4095958_2	1480694.DC28_10760	8.164e-76	260.0	arCOG05416@1|root,2ZZTD@2|Bacteria,2JAMW@203691|Spirochaetes	203691|Spirochaetes	S	lycopene cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4095958_0	714943.Mucpa_1243	2.562e-131	434.0	COG1233@1|root,COG1233@2|Bacteria,4NG7V@976|Bacteroidetes,1IR1U@117747|Sphingobacteriia	976|Bacteroidetes	Q	Flavin containing amine oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
WZS1_k127_4099199_1	926561.KB900617_gene1901	1.804e-130	424.0	COG0366@1|root,COG0366@2|Bacteria,1V0U1@1239|Firmicutes,24ZQ4@186801|Clostridia	1239|Firmicutes	G	Alpha amylase, catalytic domain	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
WZS1_k127_4099199_0	926561.KB900617_gene1422	1.368e-150	513.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
WZS1_k127_4099199_2	1463853.JOHW01000010_gene1332	1.297e-05	57.0	COG1523@1|root,COG1523@2|Bacteria,2IE3P@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_48,DUF3459
WZS1_k127_4107646_2	1122917.KB899681_gene368	2.615e-83	289.0	COG0668@1|root,COG0668@2|Bacteria,1TSHU@1239|Firmicutes,4HBC1@91061|Bacilli,26T2D@186822|Paenibacillaceae	91061|Bacilli	M	Mechanosensitive ion channel	-	-	-	ko:K16053	-	-	-	-	ko00000,ko02000	1.A.23.4.5	-	-	MS_channel
WZS1_k127_4107646_1	1307761.L21SP2_2489	5.093e-96	332.0	COG3833@1|root,COG3833@2|Bacteria,2J6AB@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
WZS1_k127_4107646_0	665571.STHERM_c10170	2.101e-97	325.0	COG1175@1|root,COG1175@2|Bacteria,2J6CI@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
WZS1_k127_412390_0	573413.Spirs_1502	5.081e-91	317.0	COG4232@1|root,COG4232@2|Bacteria,2JAQC@203691|Spirochaetes	203691|Spirochaetes	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
WZS1_k127_412390_2	889378.Spiaf_1822	3.059e-59	211.0	COG0705@1|root,COG0705@2|Bacteria,2J7J3@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	ko:K02441	-	-	-	-	ko00000	-	-	-	Rhomboid
WZS1_k127_412390_3	889378.Spiaf_1484	3.999e-26	118.0	2BZW8@1|root,32R5W@2|Bacteria,2J6GZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_412390_1	645512.GCWU000246_01632	1.398e-75	261.0	COG1738@1|root,COG1738@2|Bacteria,3TAV2@508458|Synergistetes	508458|Synergistetes	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	-	-	-	-	-	-	-	-	-	Vut_1
WZS1_k127_4146612_0	59374.Fisuc_0654	4.67e-97	320.0	COG0372@1|root,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
WZS1_k127_4146612_3	744872.Spica_0670	7.464e-20	103.0	COG3712@1|root,COG3712@2|Bacteria,2J9H5@203691|Spirochaetes	203691|Spirochaetes	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
WZS1_k127_4146612_2	744872.Spica_1165	6.742e-34	136.0	COG2314@1|root,COG2314@2|Bacteria,2J7RY@203691|Spirochaetes	203691|Spirochaetes	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
WZS1_k127_414704_0	1195236.CTER_0300	1.944e-33	144.0	COG3209@1|root,COG3409@1|root,COG3209@2|Bacteria,COG3409@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,3WNZA@541000|Ruminococcaceae	186801|Clostridia	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_S8,RHS_repeat
WZS1_k127_4148138_2	2711.XP_006470154.1	2.763e-20	95.0	COG2801@1|root,KOG0017@2759|Eukaryota,37ZJH@33090|Viridiplantae,3GPMU@35493|Streptophyta	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Chromo
WZS1_k127_4148138_4	225117.XP_009338862.1	3.016e-13	71.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids	35493|Streptophyta	H	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Chromo,RVP_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
WZS1_k127_4148138_7	4098.XP_009586987.1	0.0001348	45.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,44P0E@71274|asterids	35493|Streptophyta	L	DNA RNA polymerases superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,Retrotrans_gag
WZS1_k127_4148138_3	3694.POPTR_0015s07060.1	1.446e-15	78.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids	35493|Streptophyta	H	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
WZS1_k127_4148138_1	225117.XP_009338862.1	2.164e-29	118.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids	35493|Streptophyta	H	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Chromo,RVP_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
WZS1_k127_4148138_6	3712.Bo4g086520.1	9.243e-05	46.0	COG2801@1|root,KOG0017@2759|Eukaryota	3712.Bo4g086520.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4148138_0	3988.XP_002536987.1	1.981e-29	117.0	2EQTY@1|root,2STRZ@2759|Eukaryota,381AP@33090|Viridiplantae,3GQVM@35493|Streptophyta	35493|Streptophyta	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4148138_5	57918.XP_004301556.1	5.644e-05	45.0	COG2801@1|root,KOG0017@2759|Eukaryota,37Y7E@33090|Viridiplantae,3GN4M@35493|Streptophyta,4JUEB@91835|fabids	35493|Streptophyta	L	Retrotransposon gag protein	-	-	-	-	-	-	-	-	-	-	-	-	Retrotrans_gag,zf-CCHC
WZS1_k127_4153256_0	13333.ERN04997	1.079e-33	137.0	2CKHQ@1|root,2S5E8@2759|Eukaryota,37WKE@33090|Viridiplantae,3GKNN@35493|Streptophyta	35493|Streptophyta	S	BEST Arabidopsis thaliana protein match is Mitovirus RNA-dependent RNA polymerase (TAIR	-	-	-	-	-	-	-	-	-	-	-	-	Mitovir_RNA_pol
WZS1_k127_4153256_6	29760.VIT_12s0055g00100.t01	0.0001603	46.0	2CKHQ@1|root,2SAHI@2759|Eukaryota,37X3N@33090|Viridiplantae,3GM6W@35493|Streptophyta	35493|Streptophyta	S	Mitovirus RNA-dependent RNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Mitovir_RNA_pol
WZS1_k127_4153256_5	264402.Cagra.0259s0017.1.p	3.522e-05	46.0	2CKHQ@1|root,2S5E8@2759|Eukaryota,37WKE@33090|Viridiplantae,3GKNN@35493|Streptophyta	35493|Streptophyta	S	BEST Arabidopsis thaliana protein match is Mitovirus RNA-dependent RNA polymerase (TAIR	-	-	-	-	-	-	-	-	-	-	-	-	Mitovir_RNA_pol
WZS1_k127_4153256_1	3649.evm.model.supercontig_263.18	4.625e-28	121.0	2CKHQ@1|root,2S5E8@2759|Eukaryota,37WKE@33090|Viridiplantae,3GKNN@35493|Streptophyta,3I12S@3699|Brassicales	35493|Streptophyta	S	Mitovirus RNA-dependent RNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Mitovir_RNA_pol
WZS1_k127_4153256_3	29730.Gorai.001G160300.1	1.925e-18	88.0	2ESJY@1|root,2SV48@2759|Eukaryota,381J0@33090|Viridiplantae,3GQNG@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4153256_4	3649.evm.model.supercontig_263.18	5.574e-09	58.0	2CKHQ@1|root,2S5E8@2759|Eukaryota,37WKE@33090|Viridiplantae,3GKNN@35493|Streptophyta,3I12S@3699|Brassicales	35493|Streptophyta	S	Mitovirus RNA-dependent RNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Mitovir_RNA_pol
WZS1_k127_4153256_2	4006.Lus10009204	1.606e-21	93.0	COG0843@1|root,KOG4769@2759|Eukaryota	2759|Eukaryota	C	electron transport coupled proton transport	cox1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902600	1.9.3.1	ko:K02256	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX1,ELF
WZS1_k127_4167612_1	679926.Mpet_2733	8.75e-74	252.0	COG0588@1|root,arCOG01993@2157|Archaea,2XWCP@28890|Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
WZS1_k127_4167612_0	525257.HMPREF0204_14009	1.047e-102	341.0	COG4990@1|root,COG4990@2|Bacteria,4NFZX@976|Bacteroidetes,1HXZ6@117743|Flavobacteriia,3ZT5R@59732|Chryseobacterium	976|Bacteroidetes	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
WZS1_k127_4169193_1	642492.Clole_3198	7.83e-24	119.0	2DBM8@1|root,2Z9Y1@2|Bacteria,1VWUX@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4169193_0	1547437.LL06_12770	2.942e-30	126.0	COG1647@1|root,COG1647@2|Bacteria,1NIYY@1224|Proteobacteria,2U1Z4@28211|Alphaproteobacteria,43IXS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
WZS1_k127_4172160_2	665571.STHERM_c22200	2.187e-78	269.0	COG0154@1|root,COG0154@2|Bacteria,2J58P@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
WZS1_k127_4172160_4	665571.STHERM_c22210	7.063e-23	100.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
WZS1_k127_4172160_0	1480694.DC28_08870	2.365e-208	657.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
WZS1_k127_4172160_3	573413.Spirs_0086	3.639e-66	231.0	COG0353@1|root,COG0353@2|Bacteria,2J74I@203691|Spirochaetes	203691|Spirochaetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
WZS1_k127_4172160_5	545695.TREAZ_1793	9.719e-23	100.0	COG0718@1|root,COG0718@2|Bacteria,2J90U@203691|Spirochaetes	203691|Spirochaetes	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
WZS1_k127_4172160_1	573413.Spirs_0088	8.333e-168	535.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
WZS1_k127_417310_1	744872.Spica_1973	8.619e-75	257.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,2J5CJ@203691|Spirochaetes	203691|Spirochaetes	E	Amino-acid N-acetyltransferase	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
WZS1_k127_417310_0	1480694.DC28_09230	3.134e-170	543.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2J5CT@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD
WZS1_k127_417310_2	1167006.UWK_00694	3.642e-71	259.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
WZS1_k127_4174065_0	889378.Spiaf_0181	2.468e-131	435.0	COG1032@1|root,COG1032@2|Bacteria,2J860@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
WZS1_k127_4174065_4	1121381.JNIV01000184_gene100	3.793e-85	290.0	COG2326@1|root,COG2326@2|Bacteria,1WKEJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
WZS1_k127_4174065_2	273121.WS0108	6.287e-100	358.0	COG2199@1|root,COG2200@1|root,COG4753@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG4753@2|Bacteria,1NQKX@1224|Proteobacteria,43CB3@68525|delta/epsilon subdivisions,2YTAN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	COG2200 FOG EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,sCache_2
WZS1_k127_4174065_3	1265505.ATUG01000002_gene1498	1.383e-91	325.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
WZS1_k127_4174065_9	380703.AHA_0837	2.676e-44	183.0	COG0366@1|root,COG0366@2|Bacteria,1MVQA@1224|Proteobacteria,1RPA4@1236|Gammaproteobacteria,1Y562@135624|Aeromonadales	135624|Aeromonadales	G	Aamy_C	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,PKD
WZS1_k127_4174065_5	665571.STHERM_c03720	1.054e-51	198.0	2DM20@1|root,31DN4@2|Bacteria,2J5AS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4174065_6	313603.FB2170_15578	6.569e-51	193.0	COG3509@1|root,COG3509@2|Bacteria,4NHFS@976|Bacteroidetes,1I3VW@117743|Flavobacteriia,2PIT7@252356|Maribacter	976|Bacteroidetes	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
WZS1_k127_4174065_12	289377.HL41_05880	5.33e-16	89.0	COG0564@1|root,COG0564@2|Bacteria,2GHCF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WZS1_k127_4174065_1	1304885.AUEY01000031_gene26	2.745e-121	413.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43CQ9@68525|delta/epsilon subdivisions,2X7XI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_9,Response_reg
WZS1_k127_4174065_8	1313304.CALK_2275	3.877e-45	168.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	MA20_29145	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WZS1_k127_4174065_10	489825.LYNGBM3L_06770	1.69e-37	153.0	COG3675@1|root,COG3675@2|Bacteria,1G1NV@1117|Cyanobacteria,1HDPB@1150|Oscillatoriales	1117|Cyanobacteria	I	Lipase (class 3)	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_3
WZS1_k127_4174065_11	1304885.AUEY01000031_gene29	2.059e-17	84.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,42T1Z@68525|delta/epsilon subdivisions,2WPPA@28221|Deltaproteobacteria,2MPS6@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_2,PHY
WZS1_k127_4176486_4	795797.C497_10243	1.13e-14	79.0	COG0438@1|root,arCOG01407@2157|Archaea,2Y8BB@28890|Euryarchaeota,24180@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
WZS1_k127_4176486_1	926550.CLDAP_30030	7.285e-57	209.0	COG0030@1|root,COG0030@2|Bacteria	2|Bacteria	J	rRNA (adenine-N6,N6-)-dimethyltransferase activity	ksgA	-	2.1.1.182,2.1.1.184	ko:K00561,ko:K02528	-	-	R10716	RC00003,RC03257	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	RrnaAD
WZS1_k127_4176486_0	572544.Ilyop_0972	1.681e-148	486.0	COG2509@1|root,COG2509@2|Bacteria,378BW@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,Pyr_redox_2
WZS1_k127_4176486_2	1128421.JAGA01000002_gene503	2.736e-29	122.0	COG0537@1|root,COG0537@2|Bacteria,2NPE0@2323|unclassified Bacteria	2|Bacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
WZS1_k127_4176486_5	886293.Sinac_3966	2.473e-11	69.0	2BW4G@1|root,2ZAQH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3137
WZS1_k127_4187301_3	877418.ATWV01000009_gene302	9.257e-19	99.0	COG0658@1|root,COG0658@2|Bacteria,2J6H9@203691|Spirochaetes	203691|Spirochaetes	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence
WZS1_k127_4187301_0	889378.Spiaf_2209	6.757e-113	374.0	COG5581@1|root,COG5581@2|Bacteria,2J6AM@203691|Spirochaetes	203691|Spirochaetes	M	Type IV pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
WZS1_k127_4187301_4	1408321.JNJD01000013_gene1586	1.243e-06	58.0	COG1266@1|root,COG1266@2|Bacteria,1VF60@1239|Firmicutes,24QSC@186801|Clostridia,27PRP@186928|unclassified Lachnospiraceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
WZS1_k127_4187301_2	665571.STHERM_c06780	3.261e-21	110.0	COG0457@1|root,COG0457@2|Bacteria	665571.STHERM_c06780|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4187301_1	889378.Spiaf_1287	1.657e-91	319.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2J5K8@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
WZS1_k127_4188841_2	1333507.AUTQ01000242_gene1793	4.255e-18	90.0	COG0745@1|root,COG0745@2|Bacteria	1333507.AUTQ01000242_gene1793|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4188841_0	1333507.AUTQ01000242_gene1792	1.363e-151	488.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg,dCache_1
WZS1_k127_4188841_3	1231190.NA8A_21641	3.665e-13	72.0	2E45P@1|root,32Z1Q@2|Bacteria,1NAID@1224|Proteobacteria,2UE9K@28211|Alphaproteobacteria,43QE4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
WZS1_k127_4188841_1	1341155.FSS13T_07960	3.953e-69	254.0	COG4412@1|root,COG4932@1|root,COG5184@1|root,COG4412@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NK5Z@976|Bacteroidetes,1IKKZ@117743|Flavobacteriia,2NTPP@237|Flavobacterium	976|Bacteroidetes	DMZ	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494
WZS1_k127_4199_1	414684.RC1_2991	6.376e-28	115.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,2JPCM@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
WZS1_k127_4199_2	1480694.DC28_08230	1.453e-09	69.0	COG2197@1|root,COG5002@1|root,COG2197@2|Bacteria,COG5002@2|Bacteria,2JAU9@203691|Spirochaetes	203691|Spirochaetes	KT	COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,GerE
WZS1_k127_4208897_3	159087.Daro_3912	5.076e-26	109.0	COG0727@1|root,32S46@2|Bacteria,1MZCU@1224|Proteobacteria,2VU00@28216|Betaproteobacteria,2KX06@206389|Rhodocyclales	206389|Rhodocyclales	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WZS1_k127_4208897_0	868595.Desca_0738	3.164e-164	526.0	COG0683@1|root,COG0683@2|Bacteria,1UIZK@1239|Firmicutes,25BX6@186801|Clostridia,2675G@186807|Peptococcaceae	186801|Clostridia	E	Receptor family ligand binding region	-	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
WZS1_k127_4208897_2	645991.Sgly_2227	1.202e-92	313.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,260BU@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K11960	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
WZS1_k127_4208897_1	868595.Desca_0740	3.388e-97	334.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,266VE@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM ABC transporter, urea, permease protein, UrtC	-	-	-	ko:K01998,ko:K11961	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
WZS1_k127_4238490_1	1307761.L21SP2_3271	4.2e-61	212.0	COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WZS1_k127_4238490_0	158189.SpiBuddy_0036	2.102e-71	248.0	COG0177@1|root,COG0177@2|Bacteria,2J7HG@203691|Spirochaetes	203691|Spirochaetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
WZS1_k127_4272460_1	665571.STHERM_c11950	1.2e-62	221.0	COG1109@1|root,COG1109@2|Bacteria,2J5QI@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	cpsG	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WZS1_k127_4272460_3	596324.TREVI0001_2234	2.361e-53	193.0	COG0847@1|root,COG0847@2|Bacteria,2J80N@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
WZS1_k127_4272460_4	744872.Spica_2567	1.459e-31	125.0	COG0724@1|root,COG0724@2|Bacteria,2J8UF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
WZS1_k127_4272460_2	306281.AJLK01000109_gene3074	9.911e-59	212.0	COG0518@1|root,COG0518@2|Bacteria,1G5SC@1117|Cyanobacteria	1117|Cyanobacteria	F	glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
WZS1_k127_4272460_0	1128427.KB904821_gene2206	1.893e-96	320.0	COG0042@1|root,COG0042@2|Bacteria,1G0ME@1117|Cyanobacteria,1H79P@1150|Oscillatoriales	1117|Cyanobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
WZS1_k127_4280197_1	868595.Desca_0741	1.445e-86	294.0	COG4674@1|root,COG4674@2|Bacteria,1UIU8@1239|Firmicutes,25ES1@186801|Clostridia,267F1@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM ABC transporter, urea, ATP-binding protein, UrtD	-	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
WZS1_k127_4280197_2	868595.Desca_0742	2.356e-69	243.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996,ko:K11963	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
WZS1_k127_4280197_5	324057.Pjdr2_4328	3.491e-34	135.0	COG0831@1|root,COG0831@2|Bacteria,1V7GU@1239|Firmicutes,4HIJS@91061|Bacilli,26YAX@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the urease gamma subunit family	ureA	-	3.5.1.5	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS11965,iYO844.BSU36660	Urease_gamma
WZS1_k127_4280197_4	29540.C481_02157	2.628e-39	151.0	COG0832@1|root,arCOG04527@2157|Archaea,2XXYJ@28890|Euryarchaeota,23W9C@183963|Halobacteria	183963|Halobacteria	E	Belongs to the urease beta subunit family	ureB	-	3.5.1.5	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta
WZS1_k127_4280197_0	1120973.AQXL01000131_gene2085	6.839e-268	835.0	COG0804@1|root,COG0832@1|root,COG0804@2|Bacteria,COG0832@2|Bacteria,1TPQP@1239|Firmicutes,4HBTS@91061|Bacilli,279JS@186823|Alicyclobacillaceae	91061|Bacilli	E	Urease alpha-subunit, N-terminal domain	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
WZS1_k127_4280197_7	635013.TherJR_0609	1.098e-14	83.0	COG0830@1|root,COG0830@2|Bacteria,1V2H0@1239|Firmicutes,24ETM@186801|Clostridia,262PC@186807|Peptococcaceae	186801|Clostridia	J	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
WZS1_k127_4280197_3	870187.Thini_2957	1.311e-57	212.0	COG0310@1|root,COG0310@2|Bacteria	2|Bacteria	P	cobalt ion transport	cbiM	-	-	ko:K02007,ko:K16915	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
WZS1_k127_4280197_6	382464.ABSI01000013_gene1754	2.595e-32	127.0	COG0378@1|root,COG0378@2|Bacteria,46TJQ@74201|Verrucomicrobia,2IU5H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KO	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
WZS1_k127_4286355_6	1480694.DC28_10295	1.542e-17	89.0	COG0840@1|root,COG0840@2|Bacteria,2J81D@203691|Spirochaetes	203691|Spirochaetes	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4286355_5	208439.AJAP_41980	4.057e-21	104.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4E4FE@85010|Pseudonocardiales	201174|Actinobacteria	E	hydrolase or acyltransferase of alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
WZS1_k127_4286355_2	545694.TREPR_1506	7.277e-142	458.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
WZS1_k127_4286355_4	573413.Spirs_3046	4.908e-51	193.0	COG2890@1|root,COG2890@2|Bacteria,2J7VJ@203691|Spirochaetes	203691|Spirochaetes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
WZS1_k127_4286355_0	573413.Spirs_3047	2.9e-246	778.0	COG0317@1|root,COG0317@2|Bacteria,2J5JE@203691|Spirochaetes	203691|Spirochaetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
WZS1_k127_4286355_3	1123274.KB899432_gene2915	1.58e-117	390.0	COG0857@1|root,COG0857@2|Bacteria	2|Bacteria	C	belongs to the CobB CobQ family	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
WZS1_k127_4286355_1	665571.STHERM_c07390	8.098e-206	649.0	COG0458@1|root,COG0458@2|Bacteria,2J6A8@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
WZS1_k127_4296294_0	665571.STHERM_c09100	1.003e-89	301.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
WZS1_k127_4296294_1	1480694.DC28_02330	3.22e-88	294.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
WZS1_k127_4305862_0	1307761.L21SP2_1112	4.152e-158	505.0	COG0439@1|root,COG0439@2|Bacteria,2J5D2@203691|Spirochaetes	203691|Spirochaetes	I	Biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
WZS1_k127_4305862_1	889378.Spiaf_2212	7.973e-25	107.0	COG0777@1|root,COG0777@2|Bacteria,2J5W0@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
WZS1_k127_4311431_9	478741.JAFS01000002_gene236	2.72e-05	47.0	COG3880@1|root,COG3880@2|Bacteria,46SXX@74201|Verrucomicrobia,37GN3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	UvrB/uvrC motif	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
WZS1_k127_4311431_3	1121004.ATVC01000093_gene734	5.445e-82	283.0	COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,2WH6G@28216|Betaproteobacteria,2KPNV@206351|Neisseriales	206351|Neisseriales	H	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
WZS1_k127_4311431_2	760011.Spico_0947	2.38e-94	316.0	COG3294@1|root,COG3294@2|Bacteria,2J5Z4@203691|Spirochaetes	203691|Spirochaetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	-
WZS1_k127_4311431_4	665571.STHERM_c12410	2.458e-81	286.0	COG4591@1|root,COG4591@2|Bacteria,2J5WV@203691|Spirochaetes	203691|Spirochaetes	M	Permease protein	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
WZS1_k127_4311431_5	243275.TDE_2040	2.046e-71	247.0	COG1136@1|root,COG1136@2|Bacteria,2J6WT@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
WZS1_k127_4311431_0	545694.TREPR_1770	1.695e-98	336.0	COG4591@1|root,COG4591@2|Bacteria,2J5D9@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
WZS1_k127_4311431_1	906968.Trebr_0991	3.933e-96	322.0	COG0552@1|root,COG0552@2|Bacteria,2J5KQ@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
WZS1_k127_4311431_8	593117.TGAM_0799	1.341e-09	70.0	COG0515@1|root,arCOG02559@1|root,arCOG03264@1|root,arCOG02559@2157|Archaea,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2XYKK@28890|Euryarchaeota,24394@183968|Thermococci	183968|Thermococci	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,Pkinase
WZS1_k127_4311431_6	1307761.L21SP2_0826	1.047e-45	167.0	COG1186@1|root,COG1186@2|Bacteria,2J5QR@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
WZS1_k127_4314163_0	1379270.AUXF01000004_gene2893	2.026e-198	633.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
WZS1_k127_4314163_3	479433.Caci_6648	1.373e-06	61.0	COG2273@1|root,COG2273@2|Bacteria,2GKFN@201174|Actinobacteria	201174|Actinobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
WZS1_k127_4314163_2	1216932.CM240_0788	1.821e-88	316.0	COG0366@1|root,COG0860@1|root,COG3664@1|root,COG0366@2|Bacteria,COG0860@2|Bacteria,COG3664@2|Bacteria,1TQSE@1239|Firmicutes,24C4V@186801|Clostridia,36GZS@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Big_2,CBM26,CBM53,CW_binding_1,Y_Y_Y
WZS1_k127_4314163_1	596324.TREVI0001_0271	3.566e-198	655.0	COG2114@1|root,COG3292@1|root,COG2114@2|Bacteria,COG3292@2|Bacteria,2J5JI@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Reg_prop,Y_Y_Y
WZS1_k127_4317123_0	394503.Ccel_0862	5.947e-281	904.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_4326418_1	1429916.X566_17420	1.229e-21	99.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TTFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
WZS1_k127_4326418_0	1038866.KB902771_gene3613	3.035e-202	640.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
WZS1_k127_4326418_3	484770.UFO1_3470	2.956e-09	64.0	2ENND@1|root,33G9R@2|Bacteria,1U5US@1239|Firmicutes,4H8IX@909932|Negativicutes	909932|Negativicutes	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
WZS1_k127_4326418_2	1121472.AQWN01000002_gene2176	4.237e-18	90.0	COG1633@1|root,COG1633@2|Bacteria,1VHC3@1239|Firmicutes,24RIG@186801|Clostridia,2654Z@186807|Peptococcaceae	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
WZS1_k127_4328317_1	1089553.Tph_c21010	7.939e-27	115.0	COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HPU@186801|Clostridia,42GQC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM BioY protein	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
WZS1_k127_4328317_0	1121334.KB911073_gene1939	3.233e-31	134.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,3WHDB@541000|Ruminococcaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
WZS1_k127_4328317_2	1173026.Glo7428_3589	5.236e-22	103.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	VPA0780	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
WZS1_k127_4349587_3	573413.Spirs_0558	2.511e-70	246.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
WZS1_k127_4349587_0	573413.Spirs_0557	1.703e-169	541.0	COG0462@1|root,COG0462@2|Bacteria,2J5IY@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
WZS1_k127_4349587_4	700598.Niako_0251	1.291e-11	77.0	COG1352@1|root,COG1352@2|Bacteria,4NJ75@976|Bacteroidetes	976|Bacteroidetes	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
WZS1_k127_4349587_1	665571.STHERM_c03400	2.815e-158	510.0	COG0141@1|root,COG0141@2|Bacteria,2J5QF@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
WZS1_k127_4349587_2	158189.SpiBuddy_1776	5.549e-91	315.0	COG0285@1|root,COG0285@2|Bacteria,2J5CZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM folylpolyglutamate synthase dihydrofolate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
WZS1_k127_4363577_1	573413.Spirs_2857	7.929e-38	149.0	COG0457@1|root,COG0457@2|Bacteria,2J5XK@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_8
WZS1_k127_4363577_0	357808.RoseRS_0785	2.893e-177	561.0	COG0538@1|root,COG0538@2|Bacteria,2G5SM@200795|Chloroflexi,375VG@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,Iso_dh
WZS1_k127_436911_1	889378.Spiaf_0158	4.066e-77	267.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
WZS1_k127_436911_2	889378.Spiaf_2844	4.163e-55	198.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding,DUF2442
WZS1_k127_436911_0	889378.Spiaf_2845	4.822e-91	310.0	COG0639@1|root,COG0639@2|Bacteria,2J6GE@203691|Spirochaetes	203691|Spirochaetes	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
WZS1_k127_436911_4	906968.Trebr_1532	1.137e-11	65.0	COG0515@1|root,COG0515@2|Bacteria,2J6N6@203691|Spirochaetes	203691|Spirochaetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
WZS1_k127_4375323_7	4533.OB06G23730.1	2.34e-06	50.0	COG2801@1|root,KOG0017@2759|Eukaryota,37TRV@33090|Viridiplantae,3GUZI@35493|Streptophyta,3M6ZI@4447|Liliopsida	33090|Viridiplantae	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,Retrotrans_gag
WZS1_k127_4375323_2	3988.XP_002535288.1	1.618e-37	141.0	COG1007@1|root,KOG4668@2759|Eukaryota,37WWH@33090|Viridiplantae,3GKTY@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
WZS1_k127_4375323_3	4577.GRMZM5G804671_P01	3.843e-28	114.0	2CF62@1|root,2R4SU@2759|Eukaryota,385N3@33090|Viridiplantae,3GTKF@35493|Streptophyta,3M6GM@4447|Liliopsida,3IQCQ@38820|Poales	4577.GRMZM5G804671_P01|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4375323_10	981085.XP_010086548.1	0.0001209	45.0	2E9ST@1|root,2SG3J@2759|Eukaryota,37XH3@33090|Viridiplantae,3GMSM@35493|Streptophyta,4JVFV@91835|fabids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4375323_4	4577.GRMZM5G804671_P01	5.343e-13	73.0	2CF62@1|root,2R4SU@2759|Eukaryota,385N3@33090|Viridiplantae,3GTKF@35493|Streptophyta,3M6GM@4447|Liliopsida,3IQCQ@38820|Poales	4577.GRMZM5G804671_P01|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4375323_0	218851.Aquca_044_00131.1	1.073e-82	276.0	COG1007@1|root,KOG4668@2759|Eukaryota,37WWH@33090|Viridiplantae,3GKTY@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
WZS1_k127_4375323_1	29730.Gorai.001G167700.1	1.726e-42	160.0	COG1007@1|root,KOG4668@2759|Eukaryota,37WKT@33090|Viridiplantae,3GKHT@35493|Streptophyta	35493|Streptophyta	C	Proton-conducting membrane transporter	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_4375323_8	3750.XP_008390253.1	3.815e-06	50.0	KOG4658@1|root,KOG4658@2759|Eukaryota,37P43@33090|Viridiplantae,3GF32@35493|Streptophyta	35493|Streptophyta	T	disease resistance	-	-	-	ko:K19613	ko04014,map04014	-	-	-	ko00000,ko00001	-	-	-	FNIP,LRR_8,NB-ARC
WZS1_k127_4375323_11	4572.TRIUR3_00066-P1	0.0003683	45.0	2BX30@1|root,2R3Q5@2759|Eukaryota,384PB@33090|Viridiplantae,3GZD8@35493|Streptophyta,3M7EG@4447|Liliopsida,3IRK8@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_437859_3	1408287.AXUR01000051_gene835	2.654e-18	89.0	COG4394@1|root,COG4394@2|Bacteria,3795P@32066|Fusobacteria	32066|Fusobacteria	S	Uncharacterized protein conserved in bacteria (DUF2331)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2331
WZS1_k127_437859_1	1125725.HMPREF1325_0701	7.257e-65	226.0	COG0231@1|root,COG0231@2|Bacteria,2J69Z@203691|Spirochaetes	203691|Spirochaetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
WZS1_k127_437859_0	1537994.JQFW01000027_gene2049	6.57e-68	246.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,GGDEF,MASE3
WZS1_k127_437859_4	927658.AJUM01000011_gene1318	0.0004168	51.0	COG2304@1|root,COG2304@2|Bacteria,4NF7Y@976|Bacteroidetes,2FN4B@200643|Bacteroidia,3XJQN@558415|Marinilabiliaceae	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
WZS1_k127_437859_2	1192034.CAP_6792	1.925e-22	109.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
WZS1_k127_4386189_0	3988.XP_002535062.1	1.639e-09	58.0	KOG4669@1|root,KOG4669@2759|Eukaryota,37WZU@33090|Viridiplantae,3GKXW@35493|Streptophyta,4JVVI@91835|fabids	35493|Streptophyta	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K03882	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q2
WZS1_k127_4386892_2	889378.Spiaf_1443	5.238e-37	145.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WZS1_k127_4386892_1	545695.TREAZ_1213	8.152e-54	201.0	COG0739@1|root,COG0739@2|Bacteria,2J7J7@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
WZS1_k127_4386892_3	1123274.KB899430_gene1690	2.14e-24	104.0	COG0828@1|root,COG0828@2|Bacteria,2J8QT@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
WZS1_k127_4386892_0	321332.CYB_1374	1.864e-84	286.0	COG2133@1|root,COG2133@2|Bacteria,1G2QD@1117|Cyanobacteria,1GYDW@1129|Synechococcus	1117|Cyanobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
WZS1_k127_4411390_4	1123274.KB899415_gene2512	1.73e-83	289.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
WZS1_k127_4411390_5	744872.Spica_0136	7.795e-19	98.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
WZS1_k127_4411390_3	1307761.L21SP2_0807	1.052e-101	343.0	COG0337@1|root,COG0337@2|Bacteria,2J69J@203691|Spirochaetes	203691|Spirochaetes	H	3-dehydroquinate synthase	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
WZS1_k127_4411390_2	869210.Marky_1372	8.236e-148	492.0	COG0557@1|root,COG0557@2|Bacteria,1WIKR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
WZS1_k127_4411390_1	929556.Solca_4121	4.834e-171	551.0	COG1056@1|root,COG1056@2|Bacteria,4NKB5@976|Bacteroidetes,1IVBD@117747|Sphingobacteriia	976|Bacteroidetes	H	cytidyltransferase-related domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4411390_0	1121875.KB907547_gene2916	5.843e-205	662.0	COG1335@1|root,COG2453@1|root,COG1335@2|Bacteria,COG2453@2|Bacteria,4NXZM@976|Bacteroidetes	976|Bacteroidetes	T	Dual specificity phosphatase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	CDKN3,DSPc
WZS1_k127_4433088_10	744872.Spica_2588	3.733e-61	223.0	COG0248@1|root,COG0248@2|Bacteria,2J5XU@203691|Spirochaetes	203691|Spirochaetes	FP	Ppx GppA phosphatase family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
WZS1_k127_4433088_8	313628.LNTAR_17253	1.312e-79	276.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
WZS1_k127_4433088_15	641524.ADICYQ_2796	2.845e-06	57.0	2DM1H@1|root,31B15@2|Bacteria,4NRXQ@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4433088_5	665571.STHERM_c15680	6.962e-96	330.0	COG0438@1|root,COG0438@2|Bacteria,2J8DI@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
WZS1_k127_4433088_14	391625.PPSIR1_24944	1.297e-14	82.0	COG0664@1|root,COG0664@2|Bacteria,1N7KK@1224|Proteobacteria	1224|Proteobacteria	T	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
WZS1_k127_4433088_1	1480694.DC28_09565	4.307e-171	542.0	COG0473@1|root,COG0473@2|Bacteria,2J5FQ@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
WZS1_k127_4433088_7	760011.Spico_0166	2.517e-86	317.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
WZS1_k127_4433088_2	592029.DDD_1402	1.151e-111	374.0	COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,1HYB7@117743|Flavobacteriia,3HJJW@363408|Nonlabens	976|Bacteroidetes	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Malt_amylase_C
WZS1_k127_4433088_11	439235.Dalk_3513	3.27e-44	183.0	COG2204@1|root,COG5000@1|root,COG5002@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MPMK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
WZS1_k127_4433088_0	573413.Spirs_4285	1.137e-199	639.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2JBCT@203691|Spirochaetes	203691|Spirochaetes	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
WZS1_k127_4433088_13	573413.Spirs_4284	6.757e-33	136.0	COG0140@1|root,COG0140@2|Bacteria	2|Bacteria	E	phosphoribosyl-ATP diphosphatase activity	hisE	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31,5.3.1.16	ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04640	RC00002,RC00945,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860	PRA-CH,PRA-PH
WZS1_k127_4433088_9	1123274.KB899438_gene649	1.552e-75	261.0	COG0106@1|root,COG0106@2|Bacteria,2J8GX@203691|Spirochaetes	203691|Spirochaetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
WZS1_k127_4433088_12	1480694.DC28_12390	1.051e-39	151.0	COG1725@1|root,COG1725@2|Bacteria,2J9B8@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
WZS1_k127_4433088_4	158189.SpiBuddy_2773	9.7e-101	339.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
WZS1_k127_4433088_6	1480694.DC28_12400	1.076e-92	309.0	COG1136@1|root,COG1136@2|Bacteria,2J7FN@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
WZS1_k127_4433088_3	1480694.DC28_12405	6.484e-110	368.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
WZS1_k127_4434268_2	665571.STHERM_c14390	7.271e-152	491.0	COG0008@1|root,COG0008@2|Bacteria,2J5M7@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
WZS1_k127_4434268_0	1480694.DC28_03160	1.32e-220	691.0	COG0423@1|root,COG0423@2|Bacteria,2J57N@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
WZS1_k127_4434268_1	665571.STHERM_c14370	8.458e-163	522.0	COG0162@1|root,COG0162@2|Bacteria,2J5ZS@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
WZS1_k127_4434268_3	59374.Fisuc_0654	1.625e-76	266.0	COG0372@1|root,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
WZS1_k127_4442805_0	665571.STHERM_c20280	9.549e-118	414.0	COG0841@1|root,COG0841@2|Bacteria,2J5U5@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
WZS1_k127_4442805_1	653733.Selin_1103	4.605e-06	53.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
WZS1_k127_4473691_2	1307761.L21SP2_0552	8.323e-117	405.0	COG1501@1|root,COG1501@2|Bacteria,2J722@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
WZS1_k127_4473691_0	449447.MAE_19430	4.341e-227	746.0	COG1523@1|root,COG1523@2|Bacteria,1G219@1117|Cyanobacteria	1117|Cyanobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
WZS1_k127_4473691_8	1541960.KQ78_01705	1.485e-52	203.0	COG4188@1|root,COG4188@2|Bacteria	2|Bacteria	KT	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1400,PAF-AH_p_II
WZS1_k127_4473691_7	485918.Cpin_0488	1.422e-59	221.0	COG0635@1|root,COG0635@2|Bacteria,4NFEE@976|Bacteroidetes,1IR75@117747|Sphingobacteriia	976|Bacteroidetes	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
WZS1_k127_4473691_5	665571.STHERM_c00560	4.485e-82	295.0	COG0448@1|root,COG0448@2|Bacteria,2JBCU@203691|Spirochaetes	203691|Spirochaetes	G	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
WZS1_k127_4473691_13	1230342.CTM_14713	1.747e-25	112.0	COG4939@1|root,COG4939@2|Bacteria,1VGQ2@1239|Firmicutes,25CKP@186801|Clostridia,36WXS@31979|Clostridiaceae	186801|Clostridia	S	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
WZS1_k127_4473691_12	1121346.KB899812_gene2005	5.998e-31	133.0	COG4330@1|root,COG4330@2|Bacteria,1VEKF@1239|Firmicutes,4HPYW@91061|Bacilli,26RZG@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1361)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1361
WZS1_k127_4473691_10	1201290.M902_2429	9.018e-36	140.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,42UZH@68525|delta/epsilon subdivisions,2MTAF@213481|Bdellovibrionales,2WR2R@28221|Deltaproteobacteria	213481|Bdellovibrionales	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
WZS1_k127_4473691_3	906968.Trebr_0708	5.743e-115	377.0	COG0788@1|root,COG0788@2|Bacteria,2J7GR@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_N
WZS1_k127_4473691_11	909663.KI867150_gene298	6.478e-35	139.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1RHIK@1224|Proteobacteria,42SAD@68525|delta/epsilon subdivisions,2WPIC@28221|Deltaproteobacteria,2MQGE@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Iron (Metal) dependent repressor, DtxR family	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
WZS1_k127_4473691_16	590409.Dd586_1921	0.0004662	49.0	COG1918@1|root,COG1918@2|Bacteria,1N0KR@1224|Proteobacteria,1SA6B@1236|Gammaproteobacteria,2JEFU@204037|Dickeya	1236|Gammaproteobacteria	P	PFAM FeoA family protein	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
WZS1_k127_4473691_1	573413.Spirs_0169	7.415e-196	632.0	COG0370@1|root,COG0370@2|Bacteria,2J5ZF@203691|Spirochaetes	203691|Spirochaetes	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
WZS1_k127_4473691_6	1321778.HMPREF1982_01874	2.419e-65	231.0	COG0778@1|root,COG0778@2|Bacteria,1V2G8@1239|Firmicutes,25B06@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	ycnD	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
WZS1_k127_4473691_4	1307761.L21SP2_0103	8.019e-109	372.0	COG0366@1|root,COG0366@2|Bacteria,2J6AH@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_4473691_14	1382356.JQMP01000003_gene2228	1.258e-14	78.0	COG0142@1|root,COG0142@2|Bacteria,2G6IZ@200795|Chloroflexi,27XMM@189775|Thermomicrobia	189775|Thermomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
WZS1_k127_4477601_0	1123274.KB899417_gene2163	2.498e-237	750.0	COG0466@1|root,COG0466@2|Bacteria,2J71Y@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
WZS1_k127_4477601_2	580331.Thit_0533	3.276e-137	444.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42EK4@68295|Thermoanaerobacterales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
WZS1_k127_4477601_6	1123274.KB899417_gene2162	3.648e-22	101.0	29BJG@1|root,2ZG2E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4477601_3	744872.Spica_1099	9.968e-80	277.0	COG0618@1|root,COG0618@2|Bacteria,2J6GG@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WZS1_k127_4477601_7	665571.STHERM_c05770	5.916e-19	98.0	2AMT3@1|root,31CPK@2|Bacteria,2J8CQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4477601_4	665571.STHERM_c18540	1.721e-54	198.0	COG0127@1|root,COG0127@2|Bacteria,2J7BY@203691|Spirochaetes	203691|Spirochaetes	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
WZS1_k127_4477601_1	573413.Spirs_1288	6.766e-201	643.0	COG1164@1|root,COG1164@2|Bacteria,2J5JT@203691|Spirochaetes	203691|Spirochaetes	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
WZS1_k127_4477601_5	1120985.AUMI01000015_gene1587	3.266e-31	128.0	COG2208@1|root,COG4191@1|root,COG2208@2|Bacteria,COG4191@2|Bacteria,1TWCW@1239|Firmicutes,4H761@909932|Negativicutes	909932|Negativicutes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
WZS1_k127_4502004_6	3988.XP_002529236.1	4.337e-05	46.0	2E0M5@1|root,2S818@2759|Eukaryota,37X5I@33090|Viridiplantae	33090|Viridiplantae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4502004_7	3694.POPTR_0014s01050.1	0.0003189	45.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids	35493|Streptophyta	H	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Chromo,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
WZS1_k127_4502004_0	3880.AES75379	1.644e-89	298.0	KOG4669@1|root,KOG4669@2759|Eukaryota,388GJ@33090|Viridiplantae,3GX83@35493|Streptophyta,4JURQ@91835|fabids	35493|Streptophyta	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	-	-	-	-	-	-	-	-	-	Mt_ATP-synt_B,Oxidored_q2
WZS1_k127_4502004_1	72658.Bostr.14216s0004.1.p	3.026e-45	165.0	KOG4669@1|root,KOG4669@2759|Eukaryota,37WZU@33090|Viridiplantae,3GKXW@35493|Streptophyta	35493|Streptophyta	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K03882	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q2
WZS1_k127_4504963_0	744872.Spica_1029	7.158e-130	424.0	COG1109@1|root,COG1109@2|Bacteria,2J5QI@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	cpsG	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
WZS1_k127_4504963_3	457398.HMPREF0326_02021	5.825e-40	157.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,42USC@68525|delta/epsilon subdivisions,2X5NQ@28221|Deltaproteobacteria,2MGTH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
WZS1_k127_4504963_2	158190.SpiGrapes_0690	7.169e-72	252.0	COG0144@1|root,COG0144@2|Bacteria,2J77F@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.178	ko:K11392,ko:K21970	-	-	-	-	ko00000,ko01000,ko03009,ko03029	-	-	-	Methyltr_RsmB-F
WZS1_k127_4504963_1	744872.Spica_1027	1.159e-115	377.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
WZS1_k127_4507312_3	1307761.L21SP2_1656	1.342e-44	168.0	2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
WZS1_k127_4507312_0	1480694.DC28_11050	2.748e-115	386.0	COG1078@1|root,COG1078@2|Bacteria,2J64T@203691|Spirochaetes	203691|Spirochaetes	S	HD superfamily phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
WZS1_k127_4507312_1	243275.TDE_1121	1.898e-82	278.0	COG2172@1|root,COG2172@2|Bacteria,2J5HH@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS
WZS1_k127_4507312_2	1125701.HMPREF1221_01863	3.666e-51	183.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
WZS1_k127_4507312_4	665571.STHERM_c22280	2.455e-41	156.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2J5K8@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
WZS1_k127_4513364_0	1307761.L21SP2_0826	2.718e-84	285.0	COG1186@1|root,COG1186@2|Bacteria,2J5QR@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
WZS1_k127_4513364_5	1125700.HMPREF9195_01713	4.659e-25	106.0	2FK3B@1|root,34BRF@2|Bacteria,2J8AH@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
WZS1_k127_4513364_4	889378.Spiaf_1054	2.367e-33	145.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	3.2.1.51	ko:K01206,ko:K07114,ko:K07126	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko02000,ko04147	1.A.13.2.2,1.A.13.2.3	GH29	-	FecR,SPOR,TPR_6
WZS1_k127_4513364_1	889378.Spiaf_1053	2.366e-76	279.0	COG1449@1|root,COG1449@2|Bacteria,2J5C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
WZS1_k127_4513364_6	1007096.BAGW01000014_gene1173	7.464e-10	67.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,2N6QJ@216572|Oscillospiraceae	186801|Clostridia	C	Rnf-Nqr subunit, membrane protein	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
WZS1_k127_4513364_3	573413.Spirs_1910	8.621e-46	180.0	COG4658@1|root,COG4658@2|Bacteria,2J639@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
WZS1_k127_4513364_2	1123274.KB899415_gene2518	3.35e-69	251.0	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
WZS1_k127_4517903_1	545276.KB898726_gene1112	5.309e-144	475.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
WZS1_k127_4517903_0	313628.LNTAR_17353	1.67e-162	539.0	COG4590@1|root,COG4590@2|Bacteria	2|Bacteria	P	Binding-protein-dependent transport system inner membrane component	pstC	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
WZS1_k127_4517903_2	1499967.BAYZ01000068_gene1921	6.883e-113	374.0	COG0226@1|root,COG0226@2|Bacteria,2NQMD@2323|unclassified Bacteria	2|Bacteria	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
WZS1_k127_4517903_3	889378.Spiaf_2848	8.086e-112	377.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2,zinc_ribbon_2
WZS1_k127_4517903_4	889378.Spiaf_2847	2.062e-27	113.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,RDD,Yop-YscD_cpl
WZS1_k127_4551796_0	889378.Spiaf_2534	2.014e-57	207.0	COG2304@1|root,COG2304@2|Bacteria,2J6JM@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
WZS1_k127_4551796_1	665571.STHERM_c16770	5.205e-34	144.0	COG2304@1|root,COG2304@2|Bacteria,2J5I2@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor, type A	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_2,VWA,VWA_2
WZS1_k127_4551796_2	1307761.L21SP2_2833	3.657e-27	119.0	COG0457@1|root,COG0457@2|Bacteria,2J8PR@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
WZS1_k127_4552326_6	1480694.DC28_09040	4.466e-31	126.0	COG1575@1|root,COG1575@2|Bacteria,2J7QM@203691|Spirochaetes	203691|Spirochaetes	H	UbiA prenyltransferase family	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
WZS1_k127_4552326_4	631362.Thi970DRAFT_03972	2.786e-82	293.0	COG1541@1|root,COG1541@2|Bacteria,1PTC8@1224|Proteobacteria	1224|Proteobacteria	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
WZS1_k127_4552326_8	631362.Thi970DRAFT_03971	2.595e-18	95.0	2BIYM@1|root,32D6Z@2|Bacteria,1NDA6@1224|Proteobacteria,1SRSH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4552326_1	240016.ABIZ01000001_gene85	2.224e-172	558.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4552326_3	373994.Riv7116_5480	2.428e-96	345.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HTTD@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1
WZS1_k127_4552326_9	1403819.BATR01000040_gene1194	1.692e-11	76.0	2CX9T@1|root,32T1J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4552326_0	631362.Thi970DRAFT_03968	3.364e-225	708.0	COG0714@1|root,COG0714@2|Bacteria,1MXQ2@1224|Proteobacteria,1S1RQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
WZS1_k127_4552326_5	1120973.AQXL01000116_gene334	9.107e-54	199.0	COG3694@1|root,COG3694@2|Bacteria,1TR4N@1239|Firmicutes,4HDII@91061|Bacilli,277V9@186823|Alicyclobacillaceae	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
WZS1_k127_4552326_7	588581.Cpap_3339	1.402e-25	117.0	COG4587@1|root,COG4587@2|Bacteria,1TSAN@1239|Firmicutes,24B28@186801|Clostridia,3WI3W@541000|Ruminococcaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
WZS1_k127_4552326_2	913865.DOT_1260	1.79e-104	349.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia,260EJ@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WZS1_k127_4583358_4	1307761.L21SP2_0922	2.148e-73	252.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
WZS1_k127_4583358_0	1480694.DC28_14145	8.2e-121	403.0	COG5000@1|root,COG5000@2|Bacteria,2J5RG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
WZS1_k127_4583358_5	1307761.L21SP2_0920	6.003e-64	233.0	COG0470@1|root,COG0470@2|Bacteria,2JBGE@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
WZS1_k127_4583358_2	1480694.DC28_14160	5.939e-85	293.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
WZS1_k127_4583358_7	573413.Spirs_2473	4.311e-19	97.0	2FJEQ@1|root,34B4E@2|Bacteria,2J8EB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4583358_6	573413.Spirs_1698	1.991e-57	207.0	COG0704@1|root,COG0704@2|Bacteria,2J8BS@203691|Spirochaetes	203691|Spirochaetes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
WZS1_k127_4583358_1	1480694.DC28_14175	8.269e-88	297.0	COG0745@1|root,COG0745@2|Bacteria,2J7CK@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07657,ko:K18941	ko02020,map02020	M00434,M00716,M00717	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
WZS1_k127_4583358_3	880073.Calab_0472	2.842e-78	279.0	COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K02484,ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
WZS1_k127_4599944_1	1089547.KB913013_gene2190	5.747e-10	64.0	COG2091@1|root,COG2091@2|Bacteria,4NSRR@976|Bacteroidetes,47RBG@768503|Cytophagia	976|Bacteroidetes	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
WZS1_k127_4599944_0	322710.Avin_21220	1.287e-20	98.0	COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,1RRBX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HQ	Isochorismate synthase	entC	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008909,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016853,GO:0016866,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	5.4.4.2	ko:K01851,ko:K02361	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_0585,iECIAI1_1343.ECIAI1_0577,iECO103_1326.ECO103_0601,iECO111_1330.ECO111_0623,iECO26_1355.ECO26_0668,iECW_1372.ECW_m0648,iEKO11_1354.EKO11_3272,iEcE24377_1341.EcE24377A_0613,iSbBS512_1146.SbBS512_E0495,iUMNK88_1353.UMNK88_626,iWFL_1372.ECW_m0648	Chorismate_bind
WZS1_k127_4611518_1	754027.HMPREF9554_00965	8.977e-05	49.0	COG0741@1|root,COG0741@2|Bacteria,2J7TT@203691|Spirochaetes	203691|Spirochaetes	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
WZS1_k127_4611518_0	335543.Sfum_3112	1.678e-124	424.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MSIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WZS1_k127_461637_2	244447.XP_008313464.1	0.0003925	52.0	COG0457@1|root,KOG1124@2759|Eukaryota,38F8U@33154|Opisthokonta,3BAQE@33208|Metazoa,3CV5D@33213|Bilateria,4828P@7711|Chordata,4912M@7742|Vertebrata,49RN3@7898|Actinopterygii	33208|Metazoa	S	Transmembrane and	TMTC1	-	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
WZS1_k127_461637_0	744872.Spica_0924	4.663e-45	168.0	COG0781@1|root,COG0781@2|Bacteria,2J7V3@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
WZS1_k127_461637_1	889378.Spiaf_1627	4.228e-15	81.0	COG0760@1|root,COG0760@2|Bacteria,2J6I2@203691|Spirochaetes	203691|Spirochaetes	M	peptidylprolyl isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
WZS1_k127_4622490_0	744872.Spica_1382	8.102e-219	695.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WZS1_k127_4622490_1	221027.JO40_07745	0.0007388	49.0	2AMXE@1|root,31CUB@2|Bacteria,2J8TX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4628793_0	1235802.C823_04890	1.038e-30	130.0	COG5433@1|root,COG5433@2|Bacteria,1V0JK@1239|Firmicutes,249XC@186801|Clostridia	186801|Clostridia	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
WZS1_k127_4646245_4	744872.Spica_1516	3.361e-71	253.0	2F5GM@1|root,33VRH@2|Bacteria,2JBFA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4646245_0	1307761.L21SP2_3504	3.593e-128	419.0	COG1816@1|root,COG1816@2|Bacteria	2|Bacteria	F	deaminase activity	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
WZS1_k127_4646245_7	667014.Thein_0007	3.626e-07	54.0	COG0694@1|root,COG0694@2|Bacteria,2GI0R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
WZS1_k127_4646245_2	573413.Spirs_4301	4.041e-96	320.0	COG1192@1|root,COG1192@2|Bacteria,2J5VP@203691|Spirochaetes	203691|Spirochaetes	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
WZS1_k127_4646245_1	573413.Spirs_4300	6.615e-100	334.0	COG1475@1|root,COG1475@2|Bacteria,2J5S6@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
WZS1_k127_4646245_3	1307761.L21SP2_0736	1.113e-71	252.0	COG0791@1|root,COG0791@2|Bacteria,2J73P@203691|Spirochaetes	203691|Spirochaetes	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
WZS1_k127_4646245_6	411901.BACCAC_02146	3.431e-07	52.0	2A0M7@1|root,30NRH@2|Bacteria,4PB6T@976|Bacteroidetes,2FV5Q@200643|Bacteroidia,4ASDC@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4650364_0	243275.TDE_1558	7.621e-14	85.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
WZS1_k127_4650372_0	575615.HMPREF0670_02816	1.9e-13	81.0	COG3209@1|root,COG3209@2|Bacteria,4NF0G@976|Bacteroidetes,2FRC8@200643|Bacteroidia	976|Bacteroidetes	M	RHS repeat-associated core domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN
WZS1_k127_4672501_0	1121405.dsmv_2535	3.311e-91	306.0	COG0683@1|root,COG0683@2|Bacteria,1MYGR@1224|Proteobacteria,42YJT@68525|delta/epsilon subdivisions,2WU23@28221|Deltaproteobacteria,2MN85@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
WZS1_k127_4672501_2	1265505.ATUG01000002_gene1744	1.869e-79	271.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42QV6@68525|delta/epsilon subdivisions,2WMN1@28221|Deltaproteobacteria,2MK1Y@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
WZS1_k127_4672501_1	1265505.ATUG01000002_gene1745	7.695e-82	278.0	COG0410@1|root,COG0410@2|Bacteria,1PEAZ@1224|Proteobacteria,42YA8@68525|delta/epsilon subdivisions,2X2AX@28221|Deltaproteobacteria,2MNBB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
WZS1_k127_4680819_8	573413.Spirs_1333	5.19e-41	157.0	COG0250@1|root,COG0250@2|Bacteria,2J829@203691|Spirochaetes	203691|Spirochaetes	K	Transcription antitermination protein, NusG	-	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
WZS1_k127_4680819_1	744872.Spica_1447	6.281e-191	607.0	COG1086@1|root,COG1086@2|Bacteria,2J5C2@203691|Spirochaetes	203691|Spirochaetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,CoA_binding_3,Polysacc_synt_2
WZS1_k127_4680819_3	665571.STHERM_c08130	3.913e-113	377.0	COG0399@1|root,COG0399@2|Bacteria,2J62G@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
WZS1_k127_4680819_5	744872.Spica_1449	1.12e-75	279.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
WZS1_k127_4680819_10	1479239.JQMU01000001_gene646	1.127e-18	94.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2K4AH@204457|Sphingomonadales	204457|Sphingomonadales	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
WZS1_k127_4680819_9	1480694.DC28_11605	1.503e-27	123.0	COG1319@1|root,COG1319@2|Bacteria,2J8FR@203691|Spirochaetes	203691|Spirochaetes	C	FAD binding domain in molybdopterin dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_5
WZS1_k127_4680819_4	1313301.AUGC01000011_gene1149	6.135e-88	292.0	COG0717@1|root,COG0717@2|Bacteria,4NFRS@976|Bacteroidetes	976|Bacteroidetes	F	Deoxycytidine triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
WZS1_k127_4680819_2	1121324.CLIT_23c03200	4.356e-163	529.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,25QT6@186804|Peptostreptococcaceae	186801|Clostridia	C	L-lactate permease	lctP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
WZS1_k127_4680819_7	665571.STHERM_c13570	3.202e-55	201.0	2D94Q@1|root,32TSM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NT5C
WZS1_k127_4680819_0	318161.Sden_1800	2.381e-231	733.0	COG0366@1|root,COG0366@2|Bacteria,1MX9V@1224|Proteobacteria,1RP7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cytoplasmic alpha-amylase	amyA	GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970	Alpha-amylase,Alpha-amylase_C,DUF1939
WZS1_k127_4680819_6	889378.Spiaf_2184	5.554e-58	211.0	COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
WZS1_k127_4691955_0	1499967.BAYZ01000104_gene3640	6.484e-64	232.0	COG0438@1|root,COG0438@2|Bacteria,2NPWY@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	recX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1,RecX
WZS1_k127_4691955_1	357808.RoseRS_3143	5.663e-39	153.0	COG0558@1|root,COG0558@2|Bacteria,2G8JI@200795|Chloroflexi,377CB@32061|Chloroflexia	32061|Chloroflexia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
WZS1_k127_4697720_8	1380384.JADN01000008_gene1245	1.554e-34	137.0	COG0454@1|root,COG0456@2|Bacteria,4NQ9E@976|Bacteroidetes,1I2ZD@117743|Flavobacteriia	976|Bacteroidetes	K	(GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
WZS1_k127_4697720_2	1480694.DC28_14970	1.35e-84	295.0	COG3457@1|root,COG3457@2|Bacteria	2|Bacteria	E	Alanine racemase	alr	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0036094,GO:0036361,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0048037,GO:0050157,GO:0070279,GO:0070280,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901605	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
WZS1_k127_4697720_3	573413.Spirs_0556	1.984e-81	285.0	COG1744@1|root,COG1744@2|Bacteria,2J572@203691|Spirochaetes	203691|Spirochaetes	S	Basic membrane protein	tpn38b	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
WZS1_k127_4697720_5	1487923.DP73_12455	1.143e-65	243.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,26098@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
WZS1_k127_4697720_6	1480694.DC28_00920	6.076e-59	218.0	COG4603@1|root,COG4603@2|Bacteria,2J7BS@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WZS1_k127_4697720_7	573413.Spirs_0553	1.4e-51	193.0	COG1079@1|root,COG1079@2|Bacteria,2J81E@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WZS1_k127_4697720_0	268407.PWYN_19590	7.88e-137	441.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,274FR@186822|Paenibacillaceae	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
WZS1_k127_4697720_1	485913.Krac_0278	1.862e-136	443.0	COG0604@1|root,COG0604@2|Bacteria,2G84Q@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
WZS1_k127_4697720_9	1480694.DC28_13665	7.014e-27	115.0	2E5Q2@1|root,32M8Z@2|Bacteria,2J9FX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4697720_4	1480694.DC28_13660	1.032e-72	250.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	fecI	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
WZS1_k127_4697720_10	1283283.ATXA01000003_gene1451	1.575e-16	89.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4ERJY@85013|Frankiales	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
WZS1_k127_4715752_6	1131462.DCF50_p1653	1.36e-18	90.0	COG1433@1|root,COG1433@2|Bacteria,1VW1T@1239|Firmicutes,24KHS@186801|Clostridia	186801|Clostridia	K	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Nitro_FeMo-Co
WZS1_k127_4715752_5	572544.Ilyop_1586	4.853e-30	121.0	COG1342@1|root,COG1342@2|Bacteria,37AMV@32066|Fusobacteria	32066|Fusobacteria	S	Belongs to the UPF0251 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
WZS1_k127_4715752_2	1313304.CALK_1078	4.709e-59	214.0	COG2816@1|root,COG2816@2|Bacteria	2|Bacteria	L	NAD+ diphosphatase activity	nudC	-	1.3.7.1,3.6.1.22	ko:K03426,ko:K20449	ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146	-	R00103,R03004,R03164,R11104	RC00002,RC02422	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
WZS1_k127_4715752_0	742727.HMPREF9447_05198	9.234e-164	534.0	COG0006@1|root,COG0006@2|Bacteria,4NI1J@976|Bacteroidetes,2FNZP@200643|Bacteroidia,4AMW8@815|Bacteroidaceae	976|Bacteroidetes	E	COG0006 Xaa-Pro aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
WZS1_k127_4715752_4	171693.BN988_03329	1.817e-41	158.0	COG1846@1|root,COG1846@2|Bacteria,1V6G0@1239|Firmicutes,4HI3T@91061|Bacilli,23KBA@182709|Oceanobacillus	91061|Bacilli	K	helix_turn_helix multiple antibiotic resistance protein	ohrR	-	-	-	-	-	-	-	-	-	-	-	MarR
WZS1_k127_4715752_1	744872.Spica_0475	5.284e-80	271.0	COG2172@1|root,COG2172@2|Bacteria,2J5HH@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS
WZS1_k127_4715752_7	889378.Spiaf_1198	2.433e-14	76.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbR	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	PAS_9,RsbRD_N,Rsbr_N,STAS
WZS1_k127_4715752_3	1410609.JHVB01000002_gene1344	1.373e-51	205.0	COG2199@1|root,COG3706@2|Bacteria,2J9YD@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4721460_1	3983.cassava4.1_022884m	7.439e-33	127.0	28MAV@1|root,2QTU9@2759|Eukaryota,37TGW@33090|Viridiplantae,3GFX6@35493|Streptophyta,4JS8H@91835|fabids	35493|Streptophyta	S	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
WZS1_k127_4721460_3	2711.XP_006491480.1	5.701e-18	84.0	28MAV@1|root,2QTU9@2759|Eukaryota,37TGW@33090|Viridiplantae,3GFX6@35493|Streptophyta	35493|Streptophyta	S	Alkaline neutral invertase CINV2-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
WZS1_k127_4721460_2	2711.XP_006491480.1	1.375e-26	109.0	28MAV@1|root,2QTU9@2759|Eukaryota,37TGW@33090|Viridiplantae,3GFX6@35493|Streptophyta	35493|Streptophyta	S	Alkaline neutral invertase CINV2-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
WZS1_k127_4721460_5	4530.OS02T0125600-00	1.482e-09	61.0	2CMA4@1|root,2QPS0@2759|Eukaryota,37M9N@33090|Viridiplantae,3G75A@35493|Streptophyta,3KY36@4447|Liliopsida,3IDQ3@38820|Poales	35493|Streptophyta	S	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
WZS1_k127_4721460_0	50452.A0A087FY36	1.897e-58	202.0	28IP8@1|root,2QR09@2759|Eukaryota,37PUB@33090|Viridiplantae,3GEYD@35493|Streptophyta	35493|Streptophyta	C	Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors	psbA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0010287,GO:0016020,GO:0016168,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0046906,GO:0048037,GO:0055035,GO:0097159,GO:1901363	1.10.3.9	ko:K02703	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Photo_RC
WZS1_k127_477402_0	999411.HMPREF1092_02222	7.205e-18	96.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,36DM2@31979|Clostridiaceae	186801|Clostridia	O	PDZ DHR GLGF domain protein	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
WZS1_k127_4798816_0	29730.Gorai.001G160200.1	0.0	1096.0	COG1138@1|root,2QQ5D@2759|Eukaryota,37KAN@33090|Viridiplantae,3G7VB@35493|Streptophyta	35493|Streptophyta	O	cytochrome c	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0017004,GO:0019866,GO:0022607,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0065003,GO:0071840	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
WZS1_k127_4801668_0	4006.Lus10006594	1.02e-39	149.0	28JG1@1|root,2QRV6@2759|Eukaryota,37HEX@33090|Viridiplantae,3GE8P@35493|Streptophyta,4JRD9@91835|fabids	35493|Streptophyta	C	One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation	psbB	-	-	ko:K02704	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	PSII
WZS1_k127_4801668_2	4558.Sb10g021034.1	1.996e-07	53.0	COG2801@1|root,KOG0017@2759|Eukaryota,382M9@33090|Viridiplantae,3GS0Y@35493|Streptophyta	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4804709_0	314230.DSM3645_02453	3.749e-28	127.0	COG2730@1|root,COG2834@1|root,COG2931@1|root,COG3121@1|root,COG3209@1|root,COG3291@1|root,COG4932@1|root,COG2730@2|Bacteria,COG2834@2|Bacteria,COG2931@2|Bacteria,COG3121@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,2IWU6@203682|Planctomycetes	203682|Planctomycetes	M	TIGRFAM RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,F5_F8_type_C,RHS_repeat,VCBS
WZS1_k127_4813752_5	665571.STHERM_c13020	6.345e-39	147.0	COG1692@1|root,COG1692@2|Bacteria,2J7C4@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
WZS1_k127_4813752_3	665571.STHERM_c13010	2.546e-65	231.0	COG1189@1|root,COG1189@2|Bacteria,2J8G3@203691|Spirochaetes	203691|Spirochaetes	J	TIGRFAM hemolysin TlyA family protein	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
WZS1_k127_4813752_6	889378.Spiaf_1973	1.073e-33	147.0	COG5401@1|root,COG5401@2|Bacteria,2J7JQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
WZS1_k127_4813752_0	889378.Spiaf_1972	3.47e-187	601.0	COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes	203691|Spirochaetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
WZS1_k127_4813752_1	665571.STHERM_c12980	5.813e-137	449.0	COG1160@1|root,COG1160@2|Bacteria,2J5GG@203691|Spirochaetes	203691|Spirochaetes	I	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
WZS1_k127_4813752_4	1307761.L21SP2_1346	1.726e-60	226.0	2F2JP@1|root,33VGK@2|Bacteria,2J6EC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4813752_2	240292.Ava_0494	3.321e-82	282.0	COG0469@1|root,COG0469@2|Bacteria,1G1KV@1117|Cyanobacteria,1HJB2@1161|Nostocales	1117|Cyanobacteria	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
WZS1_k127_4822075_0	322710.Avin_21190	1.491e-139	452.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	entF	-	-	ko:K15653	ko01053,map01053	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
WZS1_k127_4823715_1	545695.TREAZ_1300	3.054e-13	78.0	2FAUG@1|root,3431P@2|Bacteria,2J8N6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4823715_0	545695.TREAZ_1297	1.03e-181	584.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2J5F4@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
WZS1_k127_4835962_0	1302858.I871_00870	2.183e-107	370.0	COG1306@1|root,COG1306@2|Bacteria,2J5BQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
WZS1_k127_4845982_2	573413.Spirs_4116	3.967e-10	63.0	COG1329@1|root,COG1329@2|Bacteria,2J7TP@203691|Spirochaetes	203691|Spirochaetes	K	Transcription factor	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
WZS1_k127_4845982_0	545694.TREPR_3139	8.284e-115	389.0	COG4166@1|root,COG4166@2|Bacteria,2J5KU@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
WZS1_k127_4845982_1	1313301.AUGC01000009_gene1028	5.482e-23	104.0	COG1704@1|root,COG1704@2|Bacteria,4P3JF@976|Bacteroidetes	976|Bacteroidetes	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
WZS1_k127_484685_3	1128421.JAGA01000001_gene2274	5.184e-59	208.0	COG1940@1|root,COG1940@2|Bacteria,2NQJS@2323|unclassified Bacteria	2|Bacteria	GK	ROK family	scrK	-	2.7.1.2,2.7.1.4	ko:K00845,ko:K00847	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
WZS1_k127_484685_2	573413.Spirs_0891	3.358e-62	227.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
WZS1_k127_484685_0	744872.Spica_2122	1.29e-159	513.0	COG1653@1|root,COG1653@2|Bacteria,2J66N@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
WZS1_k127_484685_1	744872.Spica_2121	1.921e-110	365.0	COG1175@1|root,COG1175@2|Bacteria,2J5HQ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
WZS1_k127_484685_4	1480694.DC28_08715	1.025e-36	144.0	COG0395@1|root,COG0395@2|Bacteria,2J786@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
WZS1_k127_4850348_2	4155.Migut.D01419.1.p	0.0006651	42.0	2EY1V@1|root,2SZM9@2759|Eukaryota,382EN@33090|Viridiplantae,3GMWC@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4852914_2	744872.Spica_1063	6.272e-18	98.0	2B46T@1|root,31WXW@2|Bacteria,2J8PP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4852914_0	665571.STHERM_c20250	6.135e-72	260.0	COG0845@1|root,COG0845@2|Bacteria,2J7T7@203691|Spirochaetes	203691|Spirochaetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
WZS1_k127_4852914_1	573413.Spirs_1763	4.905e-25	120.0	COG1538@1|root,COG1538@2|Bacteria,2J8W8@203691|Spirochaetes	203691|Spirochaetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
WZS1_k127_4852914_3	1125701.HMPREF1221_01812	1.097e-10	70.0	COG0457@1|root,COG0457@2|Bacteria,2JB2I@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
WZS1_k127_486626_4	203119.Cthe_2431	5.427e-51	185.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3WGC0@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
WZS1_k127_486626_2	720554.Clocl_0066	3.001e-182	581.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WGZ1@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,MTHFR_C,RnfC_N,SLBB
WZS1_k127_486626_3	1480694.DC28_04205	4.019e-72	246.0	COG1905@1|root,COG1905@2|Bacteria,2J7IH@203691|Spirochaetes	203691|Spirochaetes	C	Respiratory-chain NADH dehydrogenase 24 Kd subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
WZS1_k127_486626_5	889378.Spiaf_2406	1.103e-43	165.0	COG0642@1|root,COG2205@2|Bacteria,2J8FP@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
WZS1_k127_486626_6	573413.Spirs_3689	2.087e-43	162.0	COG3411@1|root,COG3411@2|Bacteria,2J7XQ@203691|Spirochaetes	203691|Spirochaetes	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	-
WZS1_k127_486626_0	744872.Spica_2774	2.018e-297	921.0	COG1894@1|root,COG1894@2|Bacteria,2J5MT@203691|Spirochaetes	203691|Spirochaetes	C	NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
WZS1_k127_486626_1	1480694.DC28_04185	4.313e-276	859.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6WY@203691|Spirochaetes	203691|Spirochaetes	C	Iron only hydrogenase large subunit, C-terminal domain	hymC	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3
WZS1_k127_4866282_2	1094184.KWO_0100775	0.0008316	44.0	COG0610@1|root,COG0610@2|Bacteria,1R89U@1224|Proteobacteria,1RZRD@1236|Gammaproteobacteria,1X8I7@135614|Xanthomonadales	135614|Xanthomonadales	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4866282_1	1123274.KB899406_gene1101	1.369e-27	114.0	COG2003@1|root,COG2003@2|Bacteria,2J7P5@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
WZS1_k127_4866282_0	471223.GWCH70_0153	4.281e-96	322.0	COG0010@1|root,COG0010@2|Bacteria,1TR10@1239|Firmicutes,4HAT5@91061|Bacilli,1WFNP@129337|Geobacillus	91061|Bacilli	E	Belongs to the arginase family	rocF	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
WZS1_k127_4867969_0	1307761.L21SP2_0456	1.669e-36	149.0	COG0483@1|root,COG0483@2|Bacteria,2J7MC@203691|Spirochaetes	203691|Spirochaetes	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
WZS1_k127_4867969_1	1449126.JQKL01000015_gene2908	1.015e-15	81.0	COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,269A7@186813|unclassified Clostridiales	186801|Clostridia	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
WZS1_k127_4880337_0	435591.BDI_1918	9.507e-47	173.0	COG0132@1|root,COG0132@2|Bacteria,4NGKI@976|Bacteroidetes,2FM6V@200643|Bacteroidia,22XR0@171551|Porphyromonadaceae	976|Bacteroidetes	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
WZS1_k127_489084_7	1087481.AGFX01000018_gene1619	0.0008285	47.0	COG1396@1|root,COG1396@2|Bacteria,1VBFR@1239|Firmicutes,4HM5M@91061|Bacilli,26Z7N@186822|Paenibacillaceae	91061|Bacilli	K	XRE family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
WZS1_k127_489084_6	635013.TherJR_0891	1.116e-08	60.0	COG3668@1|root,COG3668@2|Bacteria,1VK2E@1239|Firmicutes,25CYS@186801|Clostridia,2677F@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM addiction module toxin, RelE StbE family	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
WZS1_k127_489084_4	768710.DesyoDRAFT_2389	2.684e-25	107.0	COG2161@1|root,COG2161@2|Bacteria,1VG28@1239|Firmicutes,25CXM@186801|Clostridia	186801|Clostridia	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
WZS1_k127_489084_5	1156935.QWE_07436	3.869e-21	96.0	COG3806@1|root,COG3806@2|Bacteria,1R52I@1224|Proteobacteria,2U2FN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG3806 Anti-sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
WZS1_k127_489084_2	1538295.JY96_13615	2.188e-85	288.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2VI5N@28216|Betaproteobacteria,1KIXG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
WZS1_k127_489084_0	1245469.S58_33400	1.849e-158	516.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,3JTM8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
WZS1_k127_489084_1	1461693.ATO10_13049	3.309e-112	365.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TSQZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
WZS1_k127_489084_3	1218352.B597_005420	3.23e-73	251.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,1RR75@1236|Gammaproteobacteria,1Z16B@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
WZS1_k127_4896027_11	1307761.L21SP2_3466	1.73e-27	116.0	COG1238@1|root,COG1238@2|Bacteria,2JATD@203691|Spirochaetes	203691|Spirochaetes	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WZS1_k127_4896027_5	889378.Spiaf_2712	7.592e-66	235.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,GAF_2,Guanylate_cyc,HAMP,Response_reg,dCache_1
WZS1_k127_4896027_10	485916.Dtox_4267	1.644e-30	125.0	2AD7J@1|root,312WH@2|Bacteria,1V9CY@1239|Firmicutes,24SBJ@186801|Clostridia,265QE@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF1987)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1987
WZS1_k127_4896027_8	889378.Spiaf_2710	2.632e-42	161.0	2DBYH@1|root,2ZBV5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4896027_7	1042163.BRLA_c035610	5.471e-60	222.0	COG5263@1|root,COG5263@2|Bacteria,1V2GT@1239|Firmicutes,4HQKX@91061|Bacilli,27724@186822|Paenibacillaceae	91061|Bacilli	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
WZS1_k127_4896027_3	1307761.L21SP2_0078	9.551e-105	349.0	COG0418@1|root,COG0418@2|Bacteria	2|Bacteria	F	dihydroorotase activity	pyrC	GO:0003674,GO:0003824,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
WZS1_k127_4896027_9	744872.Spica_0693	1.315e-41	162.0	COG4721@1|root,COG4721@2|Bacteria,2JB0T@203691|Spirochaetes	203691|Spirochaetes	S	ABC-type cobalt transport system, permease component	-	-	-	ko:K16925	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.30	-	-	ABC_cobalt
WZS1_k127_4896027_6	744872.Spica_0692	2.861e-62	230.0	COG1123@1|root,COG4172@2|Bacteria,2JBDD@203691|Spirochaetes	203691|Spirochaetes	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
WZS1_k127_4896027_12	1307761.L21SP2_0610	7.716e-10	68.0	COG0619@1|root,COG0619@2|Bacteria,2JB7A@203691|Spirochaetes	203691|Spirochaetes	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
WZS1_k127_4896027_0	522306.CAP2UW1_1243	0.0	1447.0	COG0022@1|root,COG0332@1|root,COG0508@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0332@2|Bacteria,COG0508@2|Bacteria,COG1071@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,1KPNJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH_1	-	1.2.4.4,2.3.1.180	ko:K00648,ko:K11381	ko00061,ko00280,ko00640,ko01100,ko01110,ko01130,ko01212,map00061,map00280,map00640,map01100,map01110,map01130,map01212	M00036,M00082,M00083	R07599,R07600,R07601,R07602,R07603,R07604,R10707,R10996,R10997	RC00004,RC00027,RC00627,RC02729,RC02743,RC02883,RC02888,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
WZS1_k127_4896027_1	1005058.UMN179_01128	4.789e-178	563.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1Y7P7@135625|Pasteurellales	135625|Pasteurellales	G	Aldolase	fba	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
WZS1_k127_4896027_2	1280001.BAOA01000007_gene4050	5.552e-125	420.0	COG0366@1|root,COG0366@2|Bacteria,1PDIR@1224|Proteobacteria,1RRUN@1236|Gammaproteobacteria,1Y2KA@135623|Vibrionales	135623|Vibrionales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
WZS1_k127_4896027_4	717231.Flexsi_1518	3.037e-74	255.0	COG1048@1|root,COG1048@2|Bacteria,2GEP9@200930|Deferribacteres	200930|Deferribacteres	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
WZS1_k127_4896416_0	224911.27352613	7.653e-07	56.0	COG4249@1|root,COG4249@2|Bacteria,1MX7B@1224|Proteobacteria,2TUDI@28211|Alphaproteobacteria,3JRZ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Caspase domain	MA20_30665	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
WZS1_k127_490129_0	1121004.ATVC01000079_gene1199	3.889e-37	160.0	COG2931@1|root,COG3210@1|root,COG3386@1|root,COG4625@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2VIZZ@28216|Betaproteobacteria,2KRIE@206351|Neisseriales	206351|Neisseriales	MQU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,DUF4347
WZS1_k127_4933554_1	456442.Mboo_2407	2.119e-13	72.0	COG0784@1|root,arCOG06537@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,Response_reg
WZS1_k127_4933554_0	293826.Amet_0777	1.086e-131	436.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,36DQZ@31979|Clostridiaceae	186801|Clostridia	J	metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
WZS1_k127_49641_0	4096.XP_009766623.1	2.61e-07	53.0	COG0284@1|root,KOG1743@2759|Eukaryota,37TS0@33090|Viridiplantae,3GHX1@35493|Streptophyta,44J6Q@71274|asterids	35493|Streptophyta	P	Vesicle transport protein GOT1B-like	-	-	-	-	-	-	-	-	-	-	-	-	Got1
WZS1_k127_4979752_2	573413.Spirs_1188	3.407e-48	178.0	2E8F2@1|root,332TE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4979752_0	269084.syc1381_d	6.56e-176	566.0	COG4943@1|root,COG4943@2|Bacteria,1GE0C@1117|Cyanobacteria,1H4BE@1129|Synechococcus	1117|Cyanobacteria	T	CSS motif domain associated with EAL	-	-	-	-	-	-	-	-	-	-	-	-	CSS-motif,EAL
WZS1_k127_4979752_1	491205.JARQ01000004_gene2499	3.427e-76	267.0	COG1073@1|root,COG1073@2|Bacteria,4NJGA@976|Bacteroidetes,1IC8I@117743|Flavobacteriia,3ZTAD@59732|Chryseobacterium	976|Bacteroidetes	S	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	BAAT_C
WZS1_k127_4980878_32	90675.XP_010484806.1	1.062e-10	64.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37T71@33090|Viridiplantae,3GHK2@35493|Streptophyta,3I05T@3699|Brassicales	35493|Streptophyta	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	C2,DUF4283,RVT_1,RVT_3,zf-RVT
WZS1_k127_4980878_17	102107.XP_008228034.1	8.144e-22	98.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37T71@33090|Viridiplantae	33090|Viridiplantae	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,zf-RVT
WZS1_k127_4980878_23	3694.POPTR_1330s00200.1	5.283e-15	81.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,zf-RVT
WZS1_k127_4980878_11	13333.ERM98092	2.65e-34	132.0	COG0649@1|root,KOG2870@2759|Eukaryota,37W7Z@33090|Viridiplantae,3GKK5@35493|Streptophyta	35493|Streptophyta	C	quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_9	981085.XP_010090950.1	1.242e-35	138.0	2D43X@1|root,2STSN@2759|Eukaryota,380UQ@33090|Viridiplantae,3GQQZ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_41	4529.ORUFI12G15380.1	2.778e-07	52.0	2C11Q@1|root,2SX49@2759|Eukaryota,381WD@33090|Viridiplantae,3GRM5@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_24	4529.ORUFI12G15380.1	9.821e-15	74.0	2C11Q@1|root,2SX49@2759|Eukaryota,381WD@33090|Viridiplantae,3GRM5@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_2	3988.XP_002536610.1	3.834e-88	292.0	2BPRA@1|root,2S1SJ@2759|Eukaryota,37VGH@33090|Viridiplantae,3GHST@35493|Streptophyta,4JU79@91835|fabids	35493|Streptophyta	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_34	3988.XP_002530828.1	8.766e-10	63.0	2BPRA@1|root,2S1SJ@2759|Eukaryota,37VGH@33090|Viridiplantae,3GHST@35493|Streptophyta,4JU79@91835|fabids	35493|Streptophyta	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_18	4006.Lus10000458	1.27e-21	96.0	2BPRA@1|root,2S1SJ@2759|Eukaryota,37VGH@33090|Viridiplantae,3GHST@35493|Streptophyta	35493|Streptophyta	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_50	3659.XP_004153002.1	8.456e-05	46.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GGWT@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase (Ubiquinone) iron-sulfur protein	nad7	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3,1.6.99.3	ko:K03935	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1.6	-	-	Complex1_49kDa
WZS1_k127_4980878_1	264402.Cagra.23916s0001.1.p	2.047e-99	325.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GGWT@35493|Streptophyta,3HY69@3699|Brassicales	35493|Streptophyta	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.6.5.3,1.6.99.3	ko:K03935	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1.6	-	-	Complex1_49kDa
WZS1_k127_4980878_28	981085.XP_010107039.1	1.095e-12	67.0	COG0649@1|root,KOG2870@2759|Eukaryota,380UX@33090|Viridiplantae,3GQB9@35493|Streptophyta	35493|Streptophyta	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
WZS1_k127_4980878_38	3712.Bo01107s020.1	2.635e-08	55.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GGWT@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase (Ubiquinone) iron-sulfur protein	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
WZS1_k127_4980878_6	4572.TRIUR3_31715-P1	4.475e-54	190.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GGWT@35493|Streptophyta,3M2Z2@4447|Liliopsida,3ID3P@38820|Poales	35493|Streptophyta	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	nad7	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.6.5.3,1.6.99.3	ko:K03935	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1.6	-	-	Complex1_49kDa
WZS1_k127_4980878_5	218851.Aquca_023_00091.1	1.538e-54	191.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GGWT@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase (Ubiquinone) iron-sulfur protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
WZS1_k127_4980878_22	3712.Bo01107s020.1	3.14e-17	82.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GGWT@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase (Ubiquinone) iron-sulfur protein	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
WZS1_k127_4980878_20	3694.POPTR_0018s08080.1	2.094e-19	87.0	2E7D0@1|root,2SDZH@2759|Eukaryota,37XYK@33090|Viridiplantae,3GMPY@35493|Streptophyta,4JV54@91835|fabids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_53	29760.VIT_00s0332g00140.t01	0.0005913	44.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae	33090|Viridiplantae	C	NADH dehydrogenase ubiquinone iron-sulfur protein	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
WZS1_k127_4980878_31	4098.XP_009618060.1	7.807e-12	69.0	COG3344@1|root,KOG4768@2759|Eukaryota,37KUX@33090|Viridiplantae,3GHBI@35493|Streptophyta	35493|Streptophyta	A	NADH dehydrogenase (quinone) activity	matR	-	-	-	-	-	-	-	-	-	-	-	Intron_maturas2
WZS1_k127_4980878_44	3659.XP_004153361.1	1.792e-06	50.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GKAG@35493|Streptophyta,4JUNQ@91835|fabids	35493|Streptophyta	C	NADH dehydrogenase ubiquinone iron-sulfur protein 2-like	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
WZS1_k127_4980878_4	29760.VIT_00s0246g00010.t01	4.044e-68	232.0	COG0649@1|root,KOG2870@2759|Eukaryota,37S7T@33090|Viridiplantae,3GKAG@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase ubiquinone iron-sulfur protein 2-like	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa
WZS1_k127_4980878_35	3702.ATMG01410.1	2.213e-09	61.0	2CKHQ@1|root,2S5E8@2759|Eukaryota,37WKE@33090|Viridiplantae,3GKNN@35493|Streptophyta	35493|Streptophyta	S	BEST Arabidopsis thaliana protein match is Mitovirus RNA-dependent RNA polymerase (TAIR	-	-	-	-	-	-	-	-	-	-	-	-	Mitovir_RNA_pol
WZS1_k127_4980878_19	71139.XP_010034499.1	2.445e-20	95.0	COG2801@1|root,COG4299@1|root,KOG0017@2759|Eukaryota,KOG4683@2759|Eukaryota,37RKH@33090|Viridiplantae,3GGZK@35493|Streptophyta	35493|Streptophyta	L	strictosidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,Retrotrans_gag,rve
WZS1_k127_4980878_0	3659.XP_004152990.1	1.948e-141	454.0	COG0090@1|root,KOG0438@2759|Eukaryota,37TIQ@33090|Viridiplantae,3GHDG@35493|Streptophyta,4JS8D@91835|fabids	35493|Streptophyta	J	Ribosomal protein L2	-	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	-	-	-	-	-	-	-	-	-	Ribosomal_L2
WZS1_k127_4980878_27	3659.XP_004168533.1	5.289e-13	72.0	COG0090@1|root,KOG0438@2759|Eukaryota,37TIQ@33090|Viridiplantae,3GHDG@35493|Streptophyta,4JS8D@91835|fabids	35493|Streptophyta	J	Ribosomal protein L2	-	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	-	-	-	-	-	-	-	-	-	Ribosomal_L2
WZS1_k127_4980878_42	4537.OPUNC02G14040.1	4.024e-07	52.0	COG0090@1|root,KOG0438@2759|Eukaryota,37U0V@33090|Viridiplantae,3GI5P@35493|Streptophyta,3KS1A@4447|Liliopsida,3IDMS@38820|Poales	35493|Streptophyta	J	Ribosomal Proteins L2, C-terminal domain	-	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	-	-	-	-	-	-	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WZS1_k127_4980878_25	38727.Pavir.Aa01989.1.p	1.632e-13	70.0	COG0090@1|root,KOG0438@2759|Eukaryota,37U0V@33090|Viridiplantae,3GI5P@35493|Streptophyta,3KS1A@4447|Liliopsida,3IDMS@38820|Poales	35493|Streptophyta	J	Ribosomal Proteins L2, C-terminal domain	-	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	-	-	-	-	-	-	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WZS1_k127_4980878_30	981085.XP_010096190.1	3.714e-12	67.0	COG0090@1|root,KOG0438@2759|Eukaryota,38AJK@33090|Viridiplantae,3GSK2@35493|Streptophyta,4JUXX@91835|fabids	35493|Streptophyta	J	structural constituent of ribosome	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_48	4529.ORUFI09G18130.1	3.98e-05	49.0	29UNE@1|root,2RXJ1@2759|Eukaryota,37SK2@33090|Viridiplantae,3GFC4@35493|Streptophyta,3M51Z@4447|Liliopsida,3IG2P@38820|Poales	35493|Streptophyta	K	TCP family transcription factor	-	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031347,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0080134,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	TCP
WZS1_k127_4980878_37	3827.XP_004510058.1	2.186e-08	59.0	COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta,4JVVR@91835|fabids	35493|Streptophyta	C	NADH dehydrogenase subunit 5 C-terminus	-	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
WZS1_k127_4980878_49	3847.GLYMA17G23830.1	8.17e-05	47.0	COG1007@1|root,KOG4668@2759|Eukaryota,382PB@33090|Viridiplantae,3GQMA@35493|Streptophyta,4JVCX@91835|fabids	35493|Streptophyta	C	NADH dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_3	3702.ATMG00665.1	3.178e-77	260.0	COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta,3HYCY@3699|Brassicales	35493|Streptophyta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	-	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
WZS1_k127_4980878_13	3712.Bo01045s040.1	7.403e-28	113.0	COG1007@1|root,KOG4668@2759|Eukaryota	2759|Eukaryota	C	NADH dehydrogenase (quinone) activity	-	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH5_C,Proton_antipo_M
WZS1_k127_4980878_8	29730.Gorai.001G167800.1	1.227e-35	137.0	COG1007@1|root,KOG4668@2759|Eukaryota,382PB@33090|Viridiplantae,3GQMA@35493|Streptophyta	35493|Streptophyta	C	NADH dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_7	3880.AES58598	4.126e-43	157.0	COG1007@1|root,KOG4668@2759|Eukaryota,37NNE@33090|Viridiplantae,3GBUN@35493|Streptophyta,4JVVR@91835|fabids	35493|Streptophyta	C	NADH dehydrogenase subunit 5 C-terminus	nad5	-	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
WZS1_k127_4980878_46	3827.XP_004514805.1	1.359e-05	48.0	COG0048@1|root,COG0049@1|root,COG1007@1|root,KOG1750@2759|Eukaryota,KOG3291@2759|Eukaryota,KOG4668@2759|Eukaryota,37JZ5@33090|Viridiplantae,3GGCG@35493|Streptophyta,4JQAD@91835|fabids	35493|Streptophyta	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit	rps7-A	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23,Ribosomal_S7
WZS1_k127_4980878_47	161934.XP_010694721.1	2.419e-05	46.0	COG2801@1|root,KOG0017@2759|Eukaryota	161934.XP_010694721.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4980878_26	4081.Solyc01g007680.1.1	1.756e-13	72.0	2BZY4@1|root,2SFA2@2759|Eukaryota,37XQZ@33090|Viridiplantae,3GMPC@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4984791_2	4081.Solyc10g061880.1.1	3.992e-16	79.0	2CKIM@1|root,2SWMP@2759|Eukaryota,381WT@33090|Viridiplantae,3GRR6@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4989711_0	1123274.KB899418_gene2368	8.256e-27	119.0	2F1GF@1|root,33UH0@2|Bacteria,2J6X5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037
WZS1_k127_4992491_8	87626.PTD2_01506	2.196e-12	67.0	COG5646@1|root,COG5646@2|Bacteria,1N03F@1224|Proteobacteria,1SA9M@1236|Gammaproteobacteria,2Q32N@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WZS1_k127_4992491_3	509635.N824_28185	3.264e-52	190.0	COG4898@1|root,COG4898@2|Bacteria,4NQ4W@976|Bacteroidetes,1ISFJ@117747|Sphingobacteriia	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2200)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2200
WZS1_k127_4992491_0	756499.Desde_1511	2.606e-97	325.0	COG1657@1|root,COG1657@2|Bacteria,1TPY3@1239|Firmicutes,247MQ@186801|Clostridia,2617M@186807|Peptococcaceae	186801|Clostridia	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_4992491_7	1121090.KB894686_gene3039	8.124e-17	85.0	COG5646@1|root,COG5646@2|Bacteria,1VJMY@1239|Firmicutes,4IAJM@91061|Bacilli,1ZN47@1386|Bacillus	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WZS1_k127_4992491_5	1042163.BRLA_c041970	8.48e-30	129.0	COG3568@1|root,COG3568@2|Bacteria,1TQZG@1239|Firmicutes,4HBZQ@91061|Bacilli,274H1@186822|Paenibacillaceae	91061|Bacilli	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.3.90	ko:K06896	ko00500,map00500	-	R10486	RC00017	ko00000,ko00001,ko01000	-	-	-	Exo_endo_phos
WZS1_k127_4992491_4	771875.Ferpe_0321	2.097e-30	134.0	COG2819@1|root,COG2819@2|Bacteria,2GE2J@200918|Thermotogae	200918|Thermotogae	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
WZS1_k127_4992491_1	86416.Clopa_1957	4.988e-78	265.0	COG0663@1|root,COG0663@2|Bacteria	2|Bacteria	G	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WZS1_k127_4992491_2	640081.Dsui_3274	1.008e-53	197.0	COG0289@1|root,COG0289@2|Bacteria,1RDIK@1224|Proteobacteria,2W0J2@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Dihydrodipicolinate reductase, C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DapB_C
WZS1_k127_4992491_6	1321815.HMPREF9193_00366	8.038e-27	112.0	COG1198@1|root,COG1198@2|Bacteria	2|Bacteria	L	DNA replication, synthesis of RNA primer	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
WZS1_k127_4994960_1	158190.SpiGrapes_1650	1.421e-10	70.0	COG2963@1|root,COG2963@2|Bacteria,2JAVF@203691|Spirochaetes	203691|Spirochaetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
WZS1_k127_4994960_0	1485545.JQLW01000002_gene1483	5.25e-100	337.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_32,rve,rve_3
WZS1_k127_4995439_5	665571.STHERM_c06810	1.221e-31	129.0	COG0526@1|root,COG1328@1|root,COG0526@2|Bacteria,COG1328@2|Bacteria,2J6EG@203691|Spirochaetes	203691|Spirochaetes	CO	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin,NRDD
WZS1_k127_4995439_0	665571.STHERM_c06820	0.0	1053.0	COG1328@1|root,COG1328@2|Bacteria,2J5H0@203691|Spirochaetes	203691|Spirochaetes	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
WZS1_k127_4995439_2	1125701.HMPREF1221_00547	6.435e-57	201.0	COG1327@1|root,COG1327@2|Bacteria,2J7FW@203691|Spirochaetes	203691|Spirochaetes	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
WZS1_k127_4995439_4	1123274.KB899407_gene185	2.515e-43	167.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
WZS1_k127_4995439_1	573413.Spirs_3701	7.863e-165	530.0	COG0165@1|root,COG0165@2|Bacteria,2J5FG@203691|Spirochaetes	203691|Spirochaetes	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
WZS1_k127_4995439_3	1120953.AUBH01000003_gene2112	6.457e-45	166.0	COG0346@1|root,COG0346@2|Bacteria,1RHRF@1224|Proteobacteria,1S7BW@1236|Gammaproteobacteria,46B6Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
WZS1_k127_5003124_9	3750.XP_008392027.1	1.722e-07	53.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37TEA@33090|Viridiplantae,3GA49@35493|Streptophyta,4JVHS@91835|fabids	35493|Streptophyta	S	ribonuclease H protein	-	-	-	ko:K08504	ko04130,map04130	-	-	-	ko00000,ko00001,ko04131	-	-	-	DUF4283,Exo_endo_phos,RVT_1,zf-RVT
WZS1_k127_5003613_0	332101.JIBU02000042_gene1480	2.844e-76	263.0	COG0398@1|root,COG0398@2|Bacteria,1TRFC@1239|Firmicutes,24CYX@186801|Clostridia,36DVI@31979|Clostridiaceae	186801|Clostridia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
WZS1_k127_5003613_1	1307761.L21SP2_0942	7.382e-45	174.0	COG2897@1|root,COG2897@2|Bacteria,2JB6F@203691|Spirochaetes	203691|Spirochaetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
WZS1_k127_5003613_2	1487923.DP73_01440	3.257e-40	161.0	COG0392@1|root,COG0392@2|Bacteria,1VDGK@1239|Firmicutes,24Q29@186801|Clostridia,262MZ@186807|Peptococcaceae	186801|Clostridia	S	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
WZS1_k127_5003613_3	1121286.AUMT01000004_gene692	4.695e-10	60.0	28H95@1|root,2Z7KY@2|Bacteria,4NG37@976|Bacteroidetes,1I1NP@117743|Flavobacteriia,3ZNYX@59732|Chryseobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
WZS1_k127_5011868_6	665571.STHERM_c09280	1.608e-21	96.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
WZS1_k127_5011868_4	1480694.DC28_02410	1.195e-25	108.0	COG1987@1|root,COG1987@2|Bacteria,2J93G@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
WZS1_k127_5011868_1	1123274.KB899413_gene839	1.579e-96	323.0	COG1338@1|root,COG1338@2|Bacteria,2J5S9@203691|Spirochaetes	203691|Spirochaetes	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
WZS1_k127_5011868_5	665571.STHERM_c09250	2.794e-24	109.0	COG3190@1|root,COG3190@2|Bacteria,2J8HN@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein, FliO	-	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
WZS1_k127_5011868_2	889378.Spiaf_2091	7.996e-71	254.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2J5P8@203691|Spirochaetes	203691|Spirochaetes	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
WZS1_k127_5011868_0	889378.Spiaf_2092	3.709e-175	553.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
WZS1_k127_5011868_7	412419.BDU_282	3.495e-19	94.0	COG1580@1|root,COG1580@2|Bacteria,2J7MX@203691|Spirochaetes	203691|Spirochaetes	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
WZS1_k127_5011868_3	665571.STHERM_c09210	1.421e-27	112.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
WZS1_k127_50229_0	497964.CfE428DRAFT_6385	8.529e-05	48.0	COG3344@1|root,COG3344@2|Bacteria,46UR2@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
WZS1_k127_5026222_4	889378.Spiaf_0074	4.681e-102	359.0	COG4886@1|root,COG5337@1|root,COG4886@2|Bacteria,COG5337@2|Bacteria	2|Bacteria	M	Spore coat protein CotH	-	-	-	-	-	-	-	-	-	-	-	-	CotH
WZS1_k127_5026222_7	580332.Slit_1445	6.77e-50	188.0	2CIBN@1|root,2Z8JT@2|Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
WZS1_k127_5026222_11	1033738.CAEP01000141_gene3446	7.645e-13	75.0	2DMIK@1|root,32RUE@2|Bacteria,1VB7K@1239|Firmicutes,4HR81@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5026222_10	572544.Ilyop_1876	4.575e-15	85.0	COG3022@1|root,COG3022@2|Bacteria,37A7J@32066|Fusobacteria	32066|Fusobacteria	S	Belongs to the UPF0246 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700	-	ko:K09861	-	-	-	-	ko00000	-	-	-	H2O2_YaaD
WZS1_k127_5026222_3	1307761.L21SP2_0552	3.147e-127	434.0	COG1501@1|root,COG1501@2|Bacteria,2J722@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
WZS1_k127_5026222_8	1134474.O59_001443	2.294e-46	184.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,1RSN2@1236|Gammaproteobacteria,1FGD0@10|Cellvibrio	1236|Gammaproteobacteria	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
WZS1_k127_5026222_6	244581.IM40_04345	2.974e-71	266.0	COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,2TV5V@28211|Alphaproteobacteria,47F19@766|Rickettsiales	766|Rickettsiales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,dCache_1
WZS1_k127_5026222_9	1122212.AULO01000007_gene2321	1.007e-26	120.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1XJ6T@135619|Oceanospirillales	135619|Oceanospirillales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
WZS1_k127_5026222_1	1480694.DC28_08850	1.053e-183	583.0	COG0017@1|root,COG0017@2|Bacteria,2J73H@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
WZS1_k127_5026222_2	744872.Spica_1128	1.94e-135	436.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
WZS1_k127_5026222_0	665571.STHERM_c22190	2.02e-194	617.0	COG0064@1|root,COG0064@2|Bacteria,2J58X@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
WZS1_k127_5026222_5	665571.STHERM_c22200	4.851e-81	274.0	COG0154@1|root,COG0154@2|Bacteria,2J58P@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
WZS1_k127_5050927_4	72658.Bostr.3053s0018.1.p	1.288e-07	54.0	2D3ZV@1|root,2STDG@2759|Eukaryota,381AJ@33090|Viridiplantae,3GR1G@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5050927_5	3880.AES84212	4.487e-05	45.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta,4JVFX@91835|fabids	35493|Streptophyta	S	Cell wall-associated hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5050927_0	4113.PGSC0003DMT400089450	1.35e-55	195.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GWDE@35493|Streptophyta,44U28@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5050933_3	889378.Spiaf_1874	1.589e-29	132.0	COG0037@1|root,COG0037@2|Bacteria	2|Bacteria	D	tRNA processing	tilS	GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
WZS1_k127_5050933_1	883110.HMPREF9260_01521	4.167e-42	161.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4HH2Z@91061|Bacilli,27DU4@186827|Aerococcaceae	91061|Bacilli	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
WZS1_k127_5050933_0	1123274.KB899415_gene2429	3.037e-55	201.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
WZS1_k127_5050933_2	744872.Spica_0791	5.791e-36	139.0	COG2088@1|root,COG2088@2|Bacteria,2J7XR@203691|Spirochaetes	203691|Spirochaetes	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
WZS1_k127_5050933_4	869209.Tresu_0898	8.261e-21	96.0	COG0799@1|root,COG0799@2|Bacteria,2J84Q@203691|Spirochaetes	203691|Spirochaetes	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
WZS1_k127_5050933_5	1307761.L21SP2_1443	1.482e-19	91.0	COG1316@1|root,COG1316@2|Bacteria,2J57I@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
WZS1_k127_5055822_0	1284352.AOIG01000006_gene2814	2.128e-19	93.0	2DJV4@1|root,307FF@2|Bacteria,1U1KB@1239|Firmicutes,4IB2M@91061|Bacilli,273KZ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5055822_1	40215.BBOS01000099_gene205	4.314e-08	55.0	2AIIQ@1|root,3190S@2|Bacteria,1RHWT@1224|Proteobacteria,1S774@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cell wall assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	SUKH_5
WZS1_k127_5076727_1	1123274.KB899436_gene1289	1.49e-20	95.0	COG1459@1|root,COG1459@2|Bacteria,2J7Y9@203691|Spirochaetes	203691|Spirochaetes	U	Bacterial type II secretion system protein F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
WZS1_k127_5076727_0	1123274.KB899436_gene1290	2.786e-50	182.0	COG2165@1|root,COG2165@2|Bacteria,2J7Y8@203691|Spirochaetes	203691|Spirochaetes	NU	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
WZS1_k127_5076727_2	545694.TREPR_1391	5.957e-18	95.0	2ANKW@1|root,31DK4@2|Bacteria,2JAP9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_509263_5	907348.TresaDRAFT_0586	2.821e-43	168.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Astacin,Cu_amine_oxidN1,DinB_2
WZS1_k127_509263_6	489825.LYNGBM3L_14140	3.027e-16	84.0	COG1963@1|root,COG1963@2|Bacteria,1G5PI@1117|Cyanobacteria,1HB3C@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
WZS1_k127_509263_7	439235.Dalk_1747	1.082e-05	53.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2972@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG2972@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MHXT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,GAF_2,HAMP,HATPase_c,HisKA,Hpt,MASE2,PAS_4,PAS_9,Response_reg
WZS1_k127_509263_1	573413.Spirs_4136	1.443e-225	709.0	COG0016@1|root,COG0016@2|Bacteria,2J63H@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
WZS1_k127_509263_0	1123274.KB899414_gene3741	2.774e-229	723.0	COG0072@1|root,COG0072@2|Bacteria,2J63Q@203691|Spirochaetes	203691|Spirochaetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5,tRNA-synt_2d,tRNA_bind
WZS1_k127_509263_4	1121406.JAEX01000001_gene284	2.474e-52	199.0	COG0745@1|root,COG3920@1|root,COG0745@2|Bacteria,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,42SMY@68525|delta/epsilon subdivisions,2WPKE@28221|Deltaproteobacteria,2MAJJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg
WZS1_k127_509263_3	1480694.DC28_09620	2.464e-53	193.0	COG1225@1|root,COG1225@2|Bacteria,2J84P@203691|Spirochaetes	203691|Spirochaetes	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
WZS1_k127_509263_2	266762.HQ36_05605	2.896e-66	231.0	COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FNVV@200643|Bacteroidia,22VWR@171551|Porphyromonadaceae	976|Bacteroidetes	E	Catalyzes the hydrolysis of Xaa-His dipeptides	-	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
WZS1_k127_5092992_0	889378.Spiaf_2713	5.664e-98	339.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	srrB	-	-	ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GAF_2,HAMP,Reg_prop,SpoIIE,TPR_12,TPR_8,Y_Y_Y
WZS1_k127_5092992_1	744872.Spica_1506	3.215e-07	55.0	28UIX@1|root,2ZGPI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5108682_3	1382304.JNIL01000001_gene1716	5.866e-06	54.0	2EH6I@1|root,33AYE@2|Bacteria,1VP74@1239|Firmicutes,4HSH5@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5108682_0	1168034.FH5T_17120	3.205e-37	148.0	2CM5E@1|root,332ZW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5108682_2	1168034.FH5T_08195	7.727e-20	91.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
WZS1_k127_5108682_1	402880.MmarC5_1020	7.841e-27	119.0	COG0475@1|root,arCOG01953@2157|Archaea,2XUBF@28890|Euryarchaeota,23QBZ@183939|Methanococci	183939|Methanococci	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
WZS1_k127_511681_0	1210884.HG799465_gene11881	1.234e-74	258.0	COG4912@1|root,COG4912@2|Bacteria,2IZ0C@203682|Planctomycetes	203682|Planctomycetes	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
WZS1_k127_5123359_4	1536769.P40081_12600	4.783e-08	61.0	COG4733@1|root,COG5434@1|root,COG4733@2|Bacteria,COG5434@2|Bacteria,1TRWY@1239|Firmicutes,4HW0V@91061|Bacilli,2773H@186822|Paenibacillaceae	91061|Bacilli	M	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF1080
WZS1_k127_5123359_2	580332.Slit_2332	9.439e-63	218.0	COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,2VU64@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
WZS1_k127_5123359_3	1307761.L21SP2_1933	1.286e-28	125.0	2BZW8@1|root,33WUX@2|Bacteria,2JBFP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5123359_0	33035.JPJF01000037_gene2930	8.449e-185	599.0	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,3XZ8U@572511|Blautia	186801|Clostridia	G	Psort location Cytoplasmic, score 9.98	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
WZS1_k127_5123359_1	744872.Spica_2120	4.06e-84	281.0	COG0395@1|root,COG0395@2|Bacteria,2J786@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
WZS1_k127_515055_4	3988.XP_002535064.1	1.363e-08	59.0	2BYZD@1|root,2SMV2@2759|Eukaryota,37ZP8@33090|Viridiplantae,3GPIA@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_515055_9	3988.XP_002535064.1	8.775e-05	46.0	2BYZD@1|root,2SMV2@2759|Eukaryota,37ZP8@33090|Viridiplantae,3GPIA@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_515055_7	4006.Lus10007190	4.986e-07	53.0	COG5047@1|root,KOG1986@2759|Eukaryota,37NTS@33090|Viridiplantae,3GEAK@35493|Streptophyta,4JM1H@91835|fabids	35493|Streptophyta	U	transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Gelsolin,Sec23_BS,Sec23_helical,Sec23_trunk,zf-Sec23_Sec24
WZS1_k127_515055_2	3983.cassava4.1_001455m	1.62e-13	71.0	COG5047@1|root,KOG1986@2759|Eukaryota,37NTS@33090|Viridiplantae,3GEAK@35493|Streptophyta,4JM1H@91835|fabids	35493|Streptophyta	U	transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Gelsolin,Sec23_BS,Sec23_helical,Sec23_trunk,zf-Sec23_Sec24
WZS1_k127_515055_0	3988.XP_002515181.1	2.761e-38	143.0	COG5047@1|root,KOG1986@2759|Eukaryota,37NTS@33090|Viridiplantae,3GEAK@35493|Streptophyta,4JM1H@91835|fabids	35493|Streptophyta	U	transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Gelsolin,Sec23_BS,Sec23_helical,Sec23_trunk,zf-Sec23_Sec24
WZS1_k127_515055_5	3656.XP_008445961.1	1.525e-08	57.0	COG5047@1|root,KOG1986@2759|Eukaryota,37NTS@33090|Viridiplantae,3GEAK@35493|Streptophyta,4JM1H@91835|fabids	35493|Streptophyta	U	transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Gelsolin,Sec23_BS,Sec23_helical,Sec23_trunk,zf-Sec23_Sec24
WZS1_k127_515055_3	225117.XP_009341522.1	9.536e-11	62.0	COG5047@1|root,KOG1986@2759|Eukaryota,37NTS@33090|Viridiplantae,3GEAK@35493|Streptophyta,4JM1H@91835|fabids	35493|Streptophyta	U	transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Gelsolin,Sec23_BS,Sec23_helical,Sec23_trunk,zf-Sec23_Sec24
WZS1_k127_515055_1	3847.GLYMA03G38330.1	9.732e-15	74.0	COG5047@1|root,KOG1986@2759|Eukaryota,37NTS@33090|Viridiplantae,3GEAK@35493|Streptophyta,4JM1H@91835|fabids	35493|Streptophyta	U	transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Gelsolin,Sec23_BS,Sec23_helical,Sec23_trunk,zf-Sec23_Sec24
WZS1_k127_515122_1	754027.HMPREF9554_00051	9.026e-06	49.0	2FBAD@1|root,343GE@2|Bacteria,2J7WU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_515122_0	1041826.FCOL_06565	1.744e-11	77.0	2BWQ7@1|root,33XD9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5166716_2	889378.Spiaf_0115	1.574e-90	310.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	dosC	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0016740,GO:0016772,GO:0016779,GO:0019825,GO:0020037,GO:0036094,GO:0042165,GO:0043167,GO:0043169,GO:0046906,GO:0048037,GO:0052621,GO:0070025,GO:0097159,GO:1901363	2.7.7.65	ko:K07814,ko:K13069	-	-	R08057	-	ko00000,ko01000,ko02022	-	-	-	GGDEF,Protoglobin,Response_reg
WZS1_k127_5166716_7	1565314.OA34_05775	4.345e-07	62.0	COG4872@1|root,COG4872@2|Bacteria,1NF4D@1224|Proteobacteria,42XRT@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
WZS1_k127_5166716_6	1227266.HMPREF1551_02157	1.312e-12	75.0	COG4929@1|root,COG4929@2|Bacteria,4NQB4@976|Bacteroidetes,1I3Q6@117743|Flavobacteriia,1ES00@1016|Capnocytophaga	976|Bacteroidetes	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
WZS1_k127_5166716_4	667014.Thein_0048	2.307e-50	192.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GH0E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
WZS1_k127_5166716_0	665571.STHERM_c19480	1.798e-219	703.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	potE	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2,SLC12
WZS1_k127_5166716_5	573413.Spirs_2595	4.563e-40	160.0	2920H@1|root,2ZPJT@2|Bacteria,2J5PN@203691|Spirochaetes	203691|Spirochaetes	S	Pilus assembly protein PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
WZS1_k127_5166716_3	1211817.CCAT010000012_gene2844	4.335e-54	201.0	COG2035@1|root,COG2035@2|Bacteria,1UYD5@1239|Firmicutes,24B08@186801|Clostridia,36G4J@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
WZS1_k127_5166716_1	889378.Spiaf_1112	2.568e-155	520.0	COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	Na_H_Exchanger,PTS_EIIA_2,Usp
WZS1_k127_5207943_0	1087481.AGFX01000011_gene3653	1.357e-68	241.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli,26S8N@186822|Paenibacillaceae	91061|Bacilli	S	magnesium chelatase	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WZS1_k127_5207943_1	1382306.JNIM01000001_gene2386	7.963e-06	58.0	COG1721@1|root,COG1721@2|Bacteria,2G6Y7@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WZS1_k127_5242675_2	665571.STHERM_c15510	2.073e-117	388.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2J5ZA@203691|Spirochaetes	203691|Spirochaetes	I	CoA-substrate-specific enzyme activase	yxcA	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
WZS1_k127_5242675_0	391009.Tmel_0548	4.439e-234	749.0	COG1523@1|root,COG1523@2|Bacteria,2GC11@200918|Thermotogae	200918|Thermotogae	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
WZS1_k127_5242675_1	933262.AXAM01000151_gene828	9.756e-126	422.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
WZS1_k127_5242675_5	445970.ALIPUT_01107	5.942e-22	98.0	COG2768@1|root,COG2768@2|Bacteria,4NUN8@976|Bacteroidetes,2FUIC@200643|Bacteroidia	976|Bacteroidetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
WZS1_k127_5242675_3	1391646.AVSU01000006_gene117	1.608e-58	216.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,25RPX@186804|Peptostreptococcaceae	186801|Clostridia	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
WZS1_k127_5242675_6	553218.CAMRE0001_0014	4.792e-06	57.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2YPJ5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	DnaJ domain protein	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
WZS1_k127_5242675_4	1304880.JAGB01000001_gene629	1.142e-39	156.0	28P0Q@1|root,2ZBX8@2|Bacteria,1V22P@1239|Firmicutes,248XV@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5252059_1	498742.BSPA14S_0323	7.321e-85	294.0	COG2304@1|root,COG2304@2|Bacteria,2J5Y4@203691|Spirochaetes	203691|Spirochaetes	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
WZS1_k127_5252059_0	889378.Spiaf_2543	4.346e-234	733.0	COG0449@1|root,COG0449@2|Bacteria,2J587@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
WZS1_k127_5254099_4	744872.Spica_2579	3.324e-14	72.0	COG5000@1|root,COG5000@2|Bacteria,2J753@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
WZS1_k127_5254099_0	665571.STHERM_c22000	4.652e-172	552.0	COG2204@1|root,COG2204@2|Bacteria,2J63G@203691|Spirochaetes	203691|Spirochaetes	T	Regulatory protein	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
WZS1_k127_5254099_2	1480694.DC28_08600	1.679e-70	243.0	COG1974@1|root,COG1974@2|Bacteria,2J7ID@203691|Spirochaetes	203691|Spirochaetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
WZS1_k127_5254099_3	573413.Spirs_4056	1.02e-69	248.0	COG1466@1|root,COG1466@2|Bacteria,2J6PN@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
WZS1_k127_5254099_1	1123274.KB899414_gene3674	4.208e-90	306.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
WZS1_k127_5262717_0	642492.Clole_3398	4.569e-36	154.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia	186801|Clostridia	M	RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat
WZS1_k127_5290715_2	906968.Trebr_1672	9.591e-59	216.0	COG2843@1|root,COG2843@2|Bacteria,2J77A@203691|Spirochaetes	203691|Spirochaetes	M	Bacterial capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
WZS1_k127_5290715_4	1415778.JQMM01000001_gene2084	5.709e-12	66.0	2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria,1SV3F@1236|Gammaproteobacteria,1JBM0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5290715_1	665571.STHERM_c20610	2.413e-61	219.0	COG0177@1|root,COG0177@2|Bacteria,2J84F@203691|Spirochaetes	203691|Spirochaetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
WZS1_k127_5290715_3	1123288.SOV_1c06440	9.071e-35	144.0	COG2227@1|root,COG2227@2|Bacteria,1UXZZ@1239|Firmicutes	1239|Firmicutes	H	Methyltransferase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WZS1_k127_5290715_0	744872.Spica_0583	1.863e-74	263.0	COG0116@1|root,COG0116@2|Bacteria,2J69A@203691|Spirochaetes	203691|Spirochaetes	L	RNA methylase family UPF0020	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
WZS1_k127_5296976_0	221027.JO40_12705	5.027e-124	420.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
WZS1_k127_5330228_0	1536773.R70331_19675	3.841e-121	400.0	28I4Y@1|root,2Z88D@2|Bacteria,1TY0K@1239|Firmicutes,4I73G@91061|Bacilli,26VXY@186822|Paenibacillaceae	91061|Bacilli	S	Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5330228_4	45351.EDO31860	4.506e-05	51.0	2DZUA@1|root,2S7AZ@2759|Eukaryota,3A71P@33154|Opisthokonta,3C454@33208|Metazoa	33208|Metazoa	S	Cysteine-rich and transmembrane domain-containing protein 1	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5330228_2	700598.Niako_4808	9.767e-29	126.0	COG4977@1|root,COG4977@2|Bacteria,4PN2D@976|Bacteroidetes,1J0TN@117747|Sphingobacteriia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
WZS1_k127_5330228_1	1101190.ARWB01000001_gene1734	1.952e-40	160.0	COG3386@1|root,COG3386@2|Bacteria,1QY38@1224|Proteobacteria,2TXZ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
WZS1_k127_5330228_3	573413.Spirs_2312	1.458e-15	87.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
WZS1_k127_5334676_1	665571.STHERM_c21540	5.491e-89	299.0	COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
WZS1_k127_5334676_0	665571.STHERM_c21530	3.317e-160	515.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
WZS1_k127_5337496_20	3880.AES58603	7.219e-07	55.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta,4JT2P@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5337496_12	981085.XP_010088916.1	8.17e-14	73.0	2CB2A@1|root,2S778@2759|Eukaryota,37WXN@33090|Viridiplantae,3GK3N@35493|Streptophyta,4JR1I@91835|fabids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5337496_3	3880.AES93933	3.425e-28	119.0	COG5272@1|root,KOG2381@1|root,KOG0001@2759|Eukaryota,KOG2381@2759|Eukaryota,37RMX@33090|Viridiplantae,3G9F1@35493|Streptophyta,4JGUX@91835|fabids	35493|Streptophyta	OT	Phosphatidylinositol 4-kinase gamma 2-like	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0009651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	-	-	-	-	-	-	-	-	-	PI3_PI4_kinase,ubiquitin
WZS1_k127_5337496_0	29730.Gorai.001G164700.1	1.576e-48	174.0	2B8KU@1|root,2S0S2@2759|Eukaryota,37UKM@33090|Viridiplantae,3GJ2Y@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5337496_4	4081.Solyc03g063510.1.1	4.305e-23	101.0	COG1007@1|root,KOG4668@2759|Eukaryota,38006@33090|Viridiplantae,3GPQB@35493|Streptophyta	2759|Eukaryota	C	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases,Proton_antipo_M
WZS1_k127_5337496_2	3880.AES58603	6.161e-29	116.0	COG1007@1|root,KOG4668@2759|Eukaryota,37KKM@33090|Viridiplantae,3GCSG@35493|Streptophyta,4JT2P@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5337496_13	29730.Gorai.001G164800.1	4.701e-13	70.0	2D56W@1|root,2SXK0@2759|Eukaryota,382YC@33090|Viridiplantae,3GRP8@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5337496_14	29730.Gorai.001G164800.1	3.413e-10	61.0	2D56W@1|root,2SXK0@2759|Eukaryota,382YC@33090|Viridiplantae,3GRP8@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5337496_16	29730.Gorai.001G164800.1	9.546e-09	57.0	2D56W@1|root,2SXK0@2759|Eukaryota,382YC@33090|Viridiplantae,3GRP8@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5337496_15	3750.XP_008359376.1	1.25e-09	60.0	COG2801@1|root,KOG0017@2759|Eukaryota	3750.XP_008359376.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5337496_11	3880.AES58548	3.214e-15	79.0	COG1138@1|root,2QQ5D@2759|Eukaryota,37KAN@33090|Viridiplantae,3G7VB@35493|Streptophyta	35493|Streptophyta	O	cytochrome c	ccmFN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
WZS1_k127_5347144_4	518766.Rmar_0054	9.015e-50	185.0	COG4148@1|root,COG4148@2|Bacteria	2|Bacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
WZS1_k127_5347144_7	1384049.CD29_16405	6.149e-26	115.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,4HINV@91061|Bacilli,3IZJY@400634|Lysinibacillus	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WZS1_k127_5347144_9	1321778.HMPREF1982_03360	0.0002443	51.0	COG0202@1|root,COG0202@2|Bacteria,1U2EJ@1239|Firmicutes,24WKD@186801|Clostridia	186801|Clostridia	K	RNA polymerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5347144_5	744872.Spica_1567	4.346e-48	176.0	COG4113@1|root,COG4113@2|Bacteria,2JAV3@203691|Spirochaetes	203691|Spirochaetes	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5347144_6	744872.Spica_1568	3.44e-33	129.0	2DRMH@1|root,33CAH@2|Bacteria,2J8VW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5347144_3	1502851.FG93_04366	1.223e-59	209.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2U735@28211|Alphaproteobacteria,3JZ56@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
WZS1_k127_5347144_0	1242864.D187_005776	3.328e-174	556.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,437V1@68525|delta/epsilon subdivisions,2X34I@28221|Deltaproteobacteria,2YU7X@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
WZS1_k127_5347144_8	596324.TREVI0001_2054	2.106e-14	85.0	2AM4M@1|root,31BYU@2|Bacteria,2J5QA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5347144_2	754027.HMPREF9554_00053	8.804e-74	280.0	29WTR@1|root,30IF4@2|Bacteria,2J6NC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5347144_1	665571.STHERM_c16300	9.393e-153	491.0	COG3007@1|root,COG3007@2|Bacteria,2J582@203691|Spirochaetes	203691|Spirochaetes	I	Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA)	fabV	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050343,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
WZS1_k127_5348262_0	1480694.DC28_00545	3.016e-94	319.0	2BFJ7@1|root,329D7@2|Bacteria,2J651@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	flaA	-	-	-	-	-	-	-	-	-	-	-	FlaA
WZS1_k127_5348262_2	545695.TREAZ_1203	2.106e-10	68.0	2A6DG@1|root,30V6C@2|Bacteria,2J9H6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Germane
WZS1_k127_5348262_1	1123274.KB899412_gene1458	1.085e-45	170.0	COG0860@1|root,COG0860@2|Bacteria,2J5PE@203691|Spirochaetes	203691|Spirochaetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1
WZS1_k127_5372982_0	573413.Spirs_3240	7.693e-230	718.0	COG0459@1|root,COG0459@2|Bacteria,2J5CK@203691|Spirochaetes	203691|Spirochaetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
WZS1_k127_5372982_7	889378.Spiaf_0200	1.034e-17	86.0	28WXW@1|root,2ZIX0@2|Bacteria,2J96G@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5372982_6	1307761.L21SP2_0329	9.146e-30	121.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
WZS1_k127_5372982_1	665571.STHERM_c19500	2.205e-168	547.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
WZS1_k127_5372982_3	665571.STHERM_c19490	1.534e-74	261.0	COG0341@1|root,COG0341@2|Bacteria,2J5N7@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
WZS1_k127_5372982_2	665571.STHERM_c05590	5.513e-127	414.0	COG1052@1|root,COG1052@2|Bacteria,2J6XR@203691|Spirochaetes	203691|Spirochaetes	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
WZS1_k127_5372982_4	1307761.L21SP2_2486	6.797e-70	246.0	COG0522@1|root,COG0522@2|Bacteria,2J6UK@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
WZS1_k127_5372982_8	177437.HRM2_26950	3.163e-08	63.0	COG0619@1|root,COG0619@2|Bacteria,1Q039@1224|Proteobacteria,42RI8@68525|delta/epsilon subdivisions,2WNSV@28221|Deltaproteobacteria,2MK1S@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cobalt transport protein	-	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
WZS1_k127_5372982_5	645991.Sgly_0810	1.81e-57	209.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,261JU@186807|Peptococcaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16784,ko:K16786	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
WZS1_k127_5373255_2	264462.Bd2796	4.708e-05	49.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2MTBN@213481|Bdellovibrionales,2WK1X@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WZS1_k127_5373255_0	1027273.GZ77_12040	7.781e-103	343.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1XHEF@135619|Oceanospirillales	135619|Oceanospirillales	S	ATPase, AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
WZS1_k127_5373255_1	573413.Spirs_2337	1.147e-95	321.0	COG1234@1|root,COG1234@2|Bacteria,2J7K3@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
WZS1_k127_5379573_1	96561.Dole_0290	1.024e-72	250.0	COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,42Q82@68525|delta/epsilon subdivisions,2WMBU@28221|Deltaproteobacteria,2MI8W@213118|Desulfobacterales	28221|Deltaproteobacteria	E	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein	-	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD
WZS1_k127_5379573_2	862908.BMS_0871	7.24e-23	102.0	COG4807@1|root,COG4807@2|Bacteria,1RD33@1224|Proteobacteria,42UNP@68525|delta/epsilon subdivisions,2MUFN@213481|Bdellovibrionales,2WQ4E@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Protein of unknown function (DUF1456)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1456
WZS1_k127_5379573_0	665571.STHERM_c19070	2.915e-113	376.0	COG0683@1|root,COG0683@2|Bacteria,2J62Q@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
WZS1_k127_5383412_0	545694.TREPR_1911	0.0	1241.0	COG1197@1|root,COG1197@2|Bacteria,2J63X@203691|Spirochaetes	203691|Spirochaetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
WZS1_k127_5383412_1	889378.Spiaf_1472	9.616e-54	195.0	COG3605@1|root,COG3605@2|Bacteria,2JBCF@203691|Spirochaetes	203691|Spirochaetes	T	GAF domain	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
WZS1_k127_5387444_10	545695.TREAZ_2106	4.646e-09	61.0	COG1396@1|root,COG1396@2|Bacteria,2J97D@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
WZS1_k127_5387444_9	889378.Spiaf_2820	3.969e-21	98.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
WZS1_k127_5387444_2	889378.Spiaf_2821	5.88e-119	389.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
WZS1_k127_5387444_3	1123274.KB899407_gene397	7.667e-118	387.0	COG0330@1|root,COG0330@2|Bacteria,2J5YQ@203691|Spirochaetes	203691|Spirochaetes	O	SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
WZS1_k127_5387444_6	1122927.KB895424_gene2175	5.394e-69	243.0	COG2207@1|root,COG2207@2|Bacteria,1V8GE@1239|Firmicutes,4HK8N@91061|Bacilli,26QMX@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
WZS1_k127_5387444_8	153721.MYP_1217	4.351e-38	152.0	COG3832@1|root,COG3832@2|Bacteria,4NT4P@976|Bacteroidetes,47R8X@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
WZS1_k127_5387444_4	1321778.HMPREF1982_00048	7.624e-101	335.0	COG3694@1|root,COG3694@2|Bacteria,1TR4N@1239|Firmicutes,24A3T@186801|Clostridia	186801|Clostridia	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
WZS1_k127_5387444_5	926692.AZYG01000054_gene2306	3.58e-70	246.0	COG4587@1|root,COG4587@2|Bacteria,1TSAN@1239|Firmicutes,24B28@186801|Clostridia	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
WZS1_k127_5387444_1	195103.CPF_0175	1.372e-124	407.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia,36F1A@31979|Clostridiaceae	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WZS1_k127_5387444_0	1307761.L21SP2_3472	3.172e-204	655.0	COG1252@1|root,COG1252@2|Bacteria,2J79T@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WZS1_k127_5387444_7	545695.TREAZ_2904	3.666e-39	154.0	COG0142@1|root,COG0142@2|Bacteria,2J7G9@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
WZS1_k127_5403280_4	66897.DJ64_11460	3.201e-10	68.0	COG1595@1|root,COG1595@2|Bacteria,2GKDD@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
WZS1_k127_5403280_1	324057.Pjdr2_4054	3.322e-100	347.0	COG2755@1|root,COG5434@1|root,COG2755@2|Bacteria,COG5434@2|Bacteria,1UV7G@1239|Firmicutes,4I6ZU@91061|Bacilli,26VPE@186822|Paenibacillaceae	91061|Bacilli	EM	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,Pectate_lyase_3,SLH
WZS1_k127_5403280_2	1033734.CAET01000041_gene385	4.74e-43	179.0	COG1470@1|root,COG2247@1|root,COG4676@1|root,COG1470@2|Bacteria,COG2247@2|Bacteria,COG4676@2|Bacteria,1UVNA@1239|Firmicutes,4HTR6@91061|Bacilli,1ZJCT@1386|Bacillus	91061|Bacilli	N	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,CarboxypepD_reg
WZS1_k127_5403280_3	1463820.JOGW01000005_gene3480	1.566e-13	84.0	COG0366@1|root,COG0366@2|Bacteria,2HF76@201174|Actinobacteria	201174|Actinobacteria	G	Carbohydrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_25,fn3
WZS1_k127_5403280_0	713586.KB900536_gene1524	1.066e-116	389.0	COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,1RMP7@1236|Gammaproteobacteria,1X1AI@135613|Chromatiales	135613|Chromatiales	S	HipA N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Couple_hipA,HipA_C
WZS1_k127_5403280_7	1056820.KB900630_gene1526	2.491e-06	55.0	COG1476@1|root,COG1476@2|Bacteria,1N58S@1224|Proteobacteria,1S939@1236|Gammaproteobacteria,2PP2K@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
WZS1_k127_5403280_8	1140003.I573_02134	0.0002601	51.0	COG4097@1|root,COG4097@2|Bacteria	2|Bacteria	P	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_7,FAD_binding_6,FAD_binding_8,Ferric_reduct,NAD_binding_1,NAD_binding_6
WZS1_k127_5417711_17	1268240.ATFI01000008_gene2101	2.428e-18	85.0	COG2059@1|root,COG2059@2|Bacteria,4NNF5@976|Bacteroidetes,2FP4K@200643|Bacteroidia,4AM65@815|Bacteroidaceae	976|Bacteroidetes	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
WZS1_k127_5417711_12	657309.BXY_47150	1.906e-32	133.0	COG2059@1|root,COG2059@2|Bacteria,4NNZ1@976|Bacteroidetes,2FPBG@200643|Bacteroidia,4AKRV@815|Bacteroidaceae	976|Bacteroidetes	P	Psort location CytoplasmicMembrane, score	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
WZS1_k127_5417711_15	744872.Spica_0141	7.033e-20	95.0	COG5341@1|root,COG5341@2|Bacteria,2J8UX@203691|Spirochaetes	203691|Spirochaetes	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
WZS1_k127_5417711_9	889378.Spiaf_1983	4.36e-45	171.0	COG4769@1|root,COG4769@2|Bacteria,2J81I@203691|Spirochaetes	203691|Spirochaetes	S	heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
WZS1_k127_5417711_13	889378.Spiaf_1982	2.954e-29	127.0	2DEN8@1|root,2ZNJD@2|Bacteria,2J8NJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5417711_14	1034769.KB910518_gene1467	5.445e-20	97.0	COG0716@1|root,COG0716@2|Bacteria,1V7AG@1239|Firmicutes,4HMJF@91061|Bacilli,26Y4M@186822|Paenibacillaceae	91061|Bacilli	C	flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group	fld	-	-	ko:K03839	-	-	-	-	ko00000	-	-	-	Flavodoxin_1
WZS1_k127_5417711_5	412419.BDU_466	6.69e-58	206.0	COG0105@1|root,COG0105@2|Bacteria,2J7SQ@203691|Spirochaetes	203691|Spirochaetes	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
WZS1_k127_5417711_10	1267534.KB906756_gene391	1.755e-40	166.0	COG2382@1|root,COG2382@2|Bacteria,3Y68C@57723|Acidobacteria,2JKXQ@204432|Acidobacteriia	204432|Acidobacteriia	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
WZS1_k127_5417711_8	1480694.DC28_11515	1.467e-45	181.0	COG3325@1|root,COG3325@2|Bacteria	2|Bacteria	G	chitin binding	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,DUF4849
WZS1_k127_5417711_3	744872.Spica_0474	1.022e-59	215.0	COG0775@1|root,COG0775@2|Bacteria,2J6KX@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
WZS1_k127_5417711_2	744872.Spica_0473	8.069e-68	233.0	COG1854@1|root,COG1854@2|Bacteria,2J87D@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)	luxS	-	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000	-	-	-	LuxS
WZS1_k127_5417711_7	1480694.DC28_08810	1.703e-53	198.0	COG0115@1|root,COG0115@2|Bacteria	2|Bacteria	E	branched-chain-amino-acid transaminase activity	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
WZS1_k127_5417711_18	573413.Spirs_3774	2.706e-06	58.0	299Z2@1|root,2ZX0S@2|Bacteria,2JB3Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5417711_11	889378.Spiaf_1464	9.978e-40	153.0	COG1595@1|root,COG1595@2|Bacteria,2J891@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
WZS1_k127_5417711_16	1144275.COCOR_07807	5.803e-19	98.0	COG5662@1|root,COG5662@2|Bacteria,1Q39S@1224|Proteobacteria,4390Y@68525|delta/epsilon subdivisions,2X465@28221|Deltaproteobacteria,2YYC2@29|Myxococcales	28221|Deltaproteobacteria	K	AntiSigma factor	actD	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5417711_0	502025.Hoch_1608	6.921e-112	387.0	COG4249@1|root,COG4249@2|Bacteria,1NJ33@1224|Proteobacteria,42PEW@68525|delta/epsilon subdivisions,2WRUQ@28221|Deltaproteobacteria,2Z389@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
WZS1_k127_5417711_6	1157490.EL26_12090	6.891e-57	218.0	COG2114@1|root,COG2114@2|Bacteria,1V8X9@1239|Firmicutes,4IQCE@91061|Bacilli	91061|Bacilli	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
WZS1_k127_5417711_1	1307761.L21SP2_3480	8.584e-71	272.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5417711_4	545694.TREPR_2911	1.083e-59	213.0	COG3858@1|root,COG3858@2|Bacteria,2J6UU@203691|Spirochaetes	203691|Spirochaetes	S	hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
WZS1_k127_5446498_4	399739.Pmen_2129	8.571e-33	139.0	COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,1RY43@1236|Gammaproteobacteria,1YD2J@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2331)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2331
WZS1_k127_5446498_6	317936.Nos7107_4603	2.252e-08	65.0	COG4244@1|root,COG4244@2|Bacteria,1G0PC@1117|Cyanobacteria,1HM2F@1161|Nostocales	1117|Cyanobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5446498_3	573413.Spirs_2127	1.129e-71	254.0	COG0673@1|root,COG0673@2|Bacteria,2J6U4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
WZS1_k127_5446498_1	889378.Spiaf_2521	3.436e-193	642.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	malS	-	2.1.1.72,3.1.4.46,3.2.1.1	ko:K00571,ko:K01126,ko:K01176	ko00500,ko00564,ko01100,ko04973,map00500,map00564,map01100,map04973	-	R01030,R01470,R02108,R02112,R11262	RC00017,RC00425	ko00000,ko00001,ko01000,ko02048	-	GH13	-	Alpha-amylase,CBM26
WZS1_k127_5446498_0	889378.Spiaf_2520	0.0	1211.0	COG0366@1|root,COG1501@1|root,COG0366@2|Bacteria,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	aml1	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26,CBM53,CBM_25,CBM_35,CHB_HEX_C_1,fn3
WZS1_k127_5446498_5	1463825.JNXC01000030_gene378	1.811e-25	123.0	COG2273@1|root,COG3292@1|root,COG2273@2|Bacteria,COG3292@2|Bacteria,2GKFN@201174|Actinobacteria,4E0UE@85010|Pseudonocardiales	201174|Actinobacteria	G	Fn3 associated	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C
WZS1_k127_5446498_2	926561.KB900617_gene1901	1.856e-135	464.0	COG0366@1|root,COG0366@2|Bacteria,1V0U1@1239|Firmicutes,24ZQ4@186801|Clostridia	1239|Firmicutes	G	Alpha amylase, catalytic domain	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
WZS1_k127_5455311_2	665571.STHERM_c01340	7.734e-95	319.0	COG0021@1|root,COG0021@2|Bacteria,2J6KB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
WZS1_k127_5455311_6	1121918.ARWE01000001_gene1361	4.398e-24	111.0	COG2984@1|root,COG5002@1|root,COG2984@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WM5B@28221|Deltaproteobacteria,43U8X@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
WZS1_k127_5455311_5	1123274.KB899423_gene1582	2.468e-37	160.0	2FEQT@1|root,346PZ@2|Bacteria,2J6IX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5455311_7	118173.KB235910_gene4409	4.223e-06	59.0	COG0457@1|root,COG0457@2|Bacteria,1GQEI@1117|Cyanobacteria,1HI2Q@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8
WZS1_k127_5455311_4	1307761.L21SP2_0086	6.02e-84	289.0	COG0618@1|root,COG0618@2|Bacteria,2J7S6@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
WZS1_k127_5455311_1	889378.Spiaf_2751	4.644e-131	429.0	COG1916@1|root,COG1916@2|Bacteria,2J5K2@203691|Spirochaetes	203691|Spirochaetes	S	Pheromone shutdown protein	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
WZS1_k127_5455311_0	1123274.KB899423_gene1585	9.054e-171	550.0	COG1066@1|root,COG1066@2|Bacteria,2J5WN@203691|Spirochaetes	203691|Spirochaetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
WZS1_k127_5455311_3	1307761.L21SP2_0090	2.95e-85	305.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HTH_18,Pkinase,TPR_19,TPR_2,TPR_8
WZS1_k127_5458483_1	44251.PDUR_02845	1.581e-10	64.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,4HB1D@91061|Bacilli,26QZH@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
WZS1_k127_5458483_0	1123073.KB899241_gene2308	2.006e-157	511.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,1X3WR@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the glycosyl hydrolase 31 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
WZS1_k127_5462963_0	1307761.L21SP2_2569	2.46e-82	291.0	COG1116@1|root,COG1116@2|Bacteria	2|Bacteria	P	anion transmembrane transporter activity	MA20_26685	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
WZS1_k127_5462963_1	1307761.L21SP2_2570	1.259e-40	163.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
WZS1_k127_5462963_2	1382306.JNIM01000001_gene2387	6.646e-09	60.0	COG0714@1|root,COG0714@2|Bacteria,2G669@200795|Chloroflexi	200795|Chloroflexi	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WZS1_k127_5463846_5	1230460.C495_01575	1.135e-10	74.0	COG0061@1|root,COG0483@1|root,arCOG01348@2157|Archaea,arCOG01349@2157|Archaea,2XSW9@28890|Euryarchaeota,23T65@183963|Halobacteria	183963|Halobacteria	GH	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P,NAD_kinase
WZS1_k127_5463846_2	1449126.JQKL01000067_gene2117	3.481e-72	259.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,269V2@186813|unclassified Clostridiales	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
WZS1_k127_5463846_1	1121289.JHVL01000049_gene853	3.849e-107	351.0	COG4778@1|root,COG4778@2|Bacteria,1TS10@1239|Firmicutes,24C2T@186801|Clostridia,36ET2@31979|Clostridiaceae	186801|Clostridia	P	ATPases associated with a variety of cellular activities	phnL	-	2.7.8.37	ko:K05780	ko00440,map00440	-	R10185	RC00005,RC00063	ko00000,ko00001,ko01000	-	-	-	ABC_tran
WZS1_k127_5463846_3	768710.DesyoDRAFT_2924	2.958e-70	244.0	COG0110@1|root,COG0110@2|Bacteria,1TPKX@1239|Firmicutes,24UC5@186801|Clostridia	186801|Clostridia	S	acetyltransferase, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
WZS1_k127_5463846_0	1196031.ALEG01000041_gene2726	1.867e-159	511.0	COG3454@1|root,COG3454@2|Bacteria,1TRJ0@1239|Firmicutes,4HBDA@91061|Bacilli,1ZDS3@1386|Bacillus	91061|Bacilli	P	Amidohydrolase family	phnM	-	3.6.1.63	ko:K06162	ko00440,map00440	-	R10186	RC00002	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
WZS1_k127_5463846_4	1121289.JHVL01000049_gene856	1.339e-16	79.0	COG4107@1|root,COG4107@2|Bacteria,1TPHX@1239|Firmicutes,2494Q@186801|Clostridia,36HKV@31979|Clostridiaceae	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K05781	-	-	-	-	ko00000	-	-	-	ABC_tran
WZS1_k127_546834_2	665571.STHERM_c01830	5.323e-109	367.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,2J5XH@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	trpF	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
WZS1_k127_546834_0	889378.Spiaf_2550	8.418e-203	645.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,2J59H@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
WZS1_k127_546834_1	889378.Spiaf_2551	1.519e-184	588.0	COG0147@1|root,COG0147@2|Bacteria,2J5PF@203691|Spirochaetes	203691|Spirochaetes	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
WZS1_k127_546834_5	665571.STHERM_c01870	7.116e-23	111.0	2EVQY@1|root,33P4X@2|Bacteria,2J6X8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_546834_3	665571.STHERM_c01880	1.614e-42	165.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
WZS1_k127_546834_4	889378.Spiaf_2543	6.601e-38	143.0	COG0449@1|root,COG0449@2|Bacteria,2J587@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
WZS1_k127_5473939_4	313606.M23134_01814	6.882e-31	125.0	COG1524@1|root,COG2340@1|root,COG1524@2|Bacteria,COG2340@2|Bacteria,4NSVB@976|Bacteroidetes,47PIF@768503|Cytophagia	976|Bacteroidetes	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
WZS1_k127_5473939_3	1121430.JMLG01000031_gene1629	9.223e-46	169.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,2626H@186807|Peptococcaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
WZS1_k127_5473939_2	1168289.AJKI01000035_gene3573	5.918e-49	183.0	COG1018@1|root,COG1018@2|Bacteria,4PCD8@976|Bacteroidetes,2FXQD@200643|Bacteroidia,3XJNJ@558415|Marinilabiliaceae	976|Bacteroidetes	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
WZS1_k127_5473939_0	1480694.DC28_13205	4.046e-90	304.0	28I7A@1|root,2Z8A6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5473939_1	373903.Hore_00410	2.336e-63	230.0	COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,25KFG@186801|Clostridia,3WBHD@53433|Halanaerobiales	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
WZS1_k127_5486812_0	744872.Spica_2759	1.797e-227	714.0	COG1418@1|root,COG1418@2|Bacteria,2J5IM@203691|Spirochaetes	203691|Spirochaetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
WZS1_k127_5486812_1	1123274.KB899431_gene3253	2.925e-20	91.0	COG1692@1|root,COG1692@2|Bacteria,2J7C4@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
WZS1_k127_5490048_11	4081.Solyc00g013160.1.1	2.78e-19	89.0	2D0J1@1|root,2SEDM@2759|Eukaryota,37XX0@33090|Viridiplantae,3GMNP@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5490048_4	3694.POPTR_0248s00200.1	2.054e-61	211.0	2E43Y@1|root,2SB2A@2759|Eukaryota,37X2E@33090|Viridiplantae,3GKUQ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5490048_9	3880.AES58516	9.804e-31	122.0	COG1008@1|root,KOG4845@2759|Eukaryota,37TUR@33090|Viridiplantae,3GI7Y@35493|Streptophyta,4JUXR@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
WZS1_k127_5490048_3	59689.fgenesh1_pm.C_scaffold_3002392	3.182e-83	278.0	COG1008@1|root,KOG4845@2759|Eukaryota,37TUR@33090|Viridiplantae,3GI7Y@35493|Streptophyta	35493|Streptophyta	C	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
WZS1_k127_5490048_13	29730.Gorai.001G166500.1	7.365e-17	81.0	2F1D1@1|root,2T2DV@2759|Eukaryota,382SK@33090|Viridiplantae	33090|Viridiplantae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5490048_32	3988.XP_002518409.1	0.0003961	46.0	2D2TM@1|root,2S4Z0@2759|Eukaryota,37VXQ@33090|Viridiplantae,3GKBU@35493|Streptophyta,4JQM4@91835|fabids	35493|Streptophyta	S	RPM1-interacting protein 4-like	-	-	-	ko:K13456	ko04626,map04626	-	-	-	ko00000,ko00001	-	-	-	AvrRpt-cleavage
WZS1_k127_5490048_24	3827.XP_004497967.1	1.775e-09	61.0	COG5146@1|root,KOG4584@2759|Eukaryota	2759|Eukaryota	H	pantothenate kinase activity	-	-	2.7.1.33	ko:K09680	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF89
WZS1_k127_5490048_6	3880.AES58518	5.011e-46	166.0	2D68H@1|root,2T14J@2759|Eukaryota,38330@33090|Viridiplantae,3GRA0@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5490048_21	3988.XP_002534687.1	8.801e-10	60.0	COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GEAS@35493|Streptophyta,4JUKV@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5490048_17	3988.XP_002534687.1	7.603e-14	75.0	COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GEAS@35493|Streptophyta,4JUKV@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5490048_0	29730.Gorai.001G166300.1	4.389e-132	422.0	COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GEAS@35493|Streptophyta	35493|Streptophyta	C	Proton-conducting membrane transporter	nad4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5490048_8	29730.Gorai.001G166300.1	2.052e-36	143.0	COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GEAS@35493|Streptophyta	35493|Streptophyta	C	Proton-conducting membrane transporter	nad4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5490048_16	29730.Gorai.001G166300.1	1.408e-14	74.0	COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GEAS@35493|Streptophyta	35493|Streptophyta	C	Proton-conducting membrane transporter	nad4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5490048_5	3712.Bo1g086270.1	1.733e-54	191.0	2D6RG@1|root,2T2RH@2759|Eukaryota,382QH@33090|Viridiplantae,3GRSH@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5490048_1	3880.AES58519	8.153e-105	342.0	COG1008@1|root,KOG4845@2759|Eukaryota,37KP8@33090|Viridiplantae,3GEAS@35493|Streptophyta,4JUKV@91835|fabids	35493|Streptophyta	C	Proton-conducting membrane transporter	nad4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Proton_antipo_M
WZS1_k127_5490048_27	3694.POPTR_0001s15270.1	6.915e-08	55.0	KOG4197@1|root,KOG4197@2759|Eukaryota,37WSU@33090|Viridiplantae,3GKXY@35493|Streptophyta,4JV0K@91835|fabids	35493|Streptophyta	S	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5490048_2	3649.evm.model.supercontig_263.27	5.219e-94	309.0	COG0049@1|root,KOG3291@2759|Eukaryota,37W5M@33090|Viridiplantae,3GKAT@35493|Streptophyta,3HWSI@3699|Brassicales	35493|Streptophyta	J	ribosomal protein S7	-	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
WZS1_k127_5490048_31	3694.POPTR_0018s05970.1	0.0003034	46.0	KOG1075@1|root,KOG1075@2759|Eukaryota,380JW@33090|Viridiplantae,3GQ8I@35493|Streptophyta,4JUP9@91835|fabids	35493|Streptophyta	S	ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3
WZS1_k127_5513575_3	744872.Spica_2225	4.411e-44	168.0	COG0707@1|root,COG0707@2|Bacteria,2JABF@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3
WZS1_k127_5513575_1	1307761.L21SP2_2242	8.366e-68	244.0	COG1409@1|root,COG1409@2|Bacteria,2J6RQ@203691|Spirochaetes	203691|Spirochaetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
WZS1_k127_5513575_0	1208321.D104_13770	1.161e-81	293.0	28KNR@1|root,2Z9F7@2|Bacteria,1NC4P@1224|Proteobacteria,1RS28@1236|Gammaproteobacteria,1XP7V@135619|Oceanospirillales	135619|Oceanospirillales	S	Glycosyl hydrolase family 79, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_79n
WZS1_k127_5513575_5	1121324.CLIT_14c00530	7.09e-16	87.0	2EI5Z@1|root,33BXC@2|Bacteria,1W0PS@1239|Firmicutes,25476@186801|Clostridia	186801|Clostridia	S	Polysaccharide lyase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_lyase
WZS1_k127_5513575_2	357276.EL88_23565	3.19e-59	220.0	COG3867@1|root,COG3867@2|Bacteria,4NI3G@976|Bacteroidetes,2FM0Q@200643|Bacteroidia,4ARFR@815|Bacteroidaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 53	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
WZS1_k127_5513575_4	373903.Hore_05830	1.718e-17	91.0	COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,3WASY@53433|Halanaerobiales	186801|Clostridia	S	PFAM O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
WZS1_k127_5532285_1	744872.Spica_0680	3.237e-34	134.0	COG1528@1|root,COG1528@2|Bacteria,2J7RS@203691|Spirochaetes	203691|Spirochaetes	P	Iron-storage protein	rsgA	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
WZS1_k127_5532285_0	889378.Spiaf_2381	1.688e-305	951.0	COG0129@1|root,COG0129@2|Bacteria,2J9VG@203691|Spirochaetes	203691|Spirochaetes	H	Dehydratase family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
WZS1_k127_5536204_0	2711.XP_006485558.1	6.434e-06	48.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	ko:K03531,ko:K10443	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04121,ko04812	-	-	-	RNase_H,RVT_1
WZS1_k127_5537729_2	889378.Spiaf_2723	2.786e-08	55.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
WZS1_k127_5537729_0	573413.Spirs_2852	1.235e-50	203.0	2F2R9@1|root,33VMJ@2|Bacteria,2J5DF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
WZS1_k127_5537729_1	545694.TREPR_2108	1.999e-24	111.0	COG1943@1|root,COG1943@2|Bacteria,2JB6T@203691|Spirochaetes	203691|Spirochaetes	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
WZS1_k127_5544829_7	596324.TREVI0001_0588	9.758e-16	81.0	COG0841@1|root,COG0841@2|Bacteria,2JBCY@203691|Spirochaetes	203691|Spirochaetes	V	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
WZS1_k127_5544829_6	1284352.AOIG01000017_gene4494	8.817e-17	84.0	COG4627@1|root,COG4627@2|Bacteria,1UMZS@1239|Firmicutes,4IUPP@91061|Bacilli,277PK@186822|Paenibacillaceae	91061|Bacilli	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
WZS1_k127_5544829_0	889378.Spiaf_1349	4.529e-112	372.0	COG1600@1|root,COG1600@2|Bacteria,2JARS@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
WZS1_k127_5544829_3	796606.BMMGA3_11640	8.82e-45	169.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,4HHRQ@91061|Bacilli,1ZC72@1386|Bacillus	91061|Bacilli	S	COG0491 Zn-dependent hydrolases, including glyoxylases	yqgX	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
WZS1_k127_5544829_4	1280001.BAOA01000007_gene3914	7.624e-41	158.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,1RPDF@1236|Gammaproteobacteria,1XU29@135623|Vibrionales	1236|Gammaproteobacteria	G	COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
WZS1_k127_5544829_1	742738.HMPREF9460_00237	5.084e-106	353.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,2681M@186813|unclassified Clostridiales	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
WZS1_k127_5544829_2	1499967.BAYZ01000182_gene4443	9.973e-70	250.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,2NR1F@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HD_5,HisKA,PAS_4,Response_reg
WZS1_k127_5544829_5	656519.Halsa_0195	4.795e-23	109.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_9,Response_reg
WZS1_k127_5547927_0	1123274.KB899428_gene1828	9.044e-96	327.0	COG1199@1|root,COG1199@2|Bacteria,2J626@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RadC,ResIII
WZS1_k127_5547927_1	545694.TREPR_2759	2.035e-29	119.0	COG0234@1|root,COG0234@2|Bacteria,2J8BR@203691|Spirochaetes	203691|Spirochaetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
WZS1_k127_557152_1	573413.Spirs_1886	1.433e-39	149.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
WZS1_k127_557152_2	665571.STHERM_c11910	1.085e-34	139.0	2FCY0@1|root,3437Z@2|Bacteria,2JBFD@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_557152_0	1307761.L21SP2_1269	1.265e-40	159.0	COG1413@1|root,COG1413@2|Bacteria,2J61J@203691|Spirochaetes	203691|Spirochaetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
WZS1_k127_557152_3	521010.BbiDN127_0711	9.597e-09	63.0	2EFYN@1|root,339QT@2|Bacteria,2J98F@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5574617_8	665571.STHERM_c11360	2.224e-19	93.0	COG0681@1|root,COG0681@2|Bacteria,2J6RU@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB-2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
WZS1_k127_5574617_7	243275.TDE_1465	2.699e-34	141.0	COG0681@1|root,COG0681@2|Bacteria,2J7DH@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB_1	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
WZS1_k127_5574617_9	667014.Thein_1714	4.465e-05	55.0	COG0635@1|root,COG0635@2|Bacteria,2GHD8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
WZS1_k127_5574617_1	744872.Spica_1339	8.451e-98	325.0	COG0217@1|root,COG0217@2|Bacteria,2J634@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
WZS1_k127_5574617_4	656519.Halsa_1654	5.634e-48	176.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,3WBQ3@53433|Halanaerobiales	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
WZS1_k127_5574617_5	221027.JO40_10080	6.248e-40	156.0	COG0632@1|root,COG0632@2|Bacteria,2J6FC@203691|Spirochaetes	203691|Spirochaetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
WZS1_k127_5574617_0	573413.Spirs_2017	6.252e-139	449.0	COG2255@1|root,COG2255@2|Bacteria,2J5IU@203691|Spirochaetes	203691|Spirochaetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
WZS1_k127_5574617_2	748247.AZKH_3694	7.978e-77	269.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,2KVHN@206389|Rhodocyclales	206389|Rhodocyclales	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
WZS1_k127_5574617_3	665571.STHERM_c11280	4.608e-73	251.0	2C2MH@1|root,33D2Y@2|Bacteria,2J70Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5574617_6	545695.TREAZ_0555	2.125e-36	145.0	COG0125@1|root,COG0125@2|Bacteria,2J765@203691|Spirochaetes	203691|Spirochaetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
WZS1_k127_5578511_0	889378.Spiaf_0198	9.482e-181	575.0	COG0364@1|root,COG0364@2|Bacteria,2J6N0@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
WZS1_k127_5578511_2	889378.Spiaf_0197	1.205e-48	186.0	COG3429@1|root,COG3429@2|Bacteria,2JB35@203691|Spirochaetes	203691|Spirochaetes	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
WZS1_k127_5578511_1	1307761.L21SP2_3024	2.273e-66	245.0	COG1315@1|root,COG1315@2|Bacteria,2J6E5@203691|Spirochaetes	203691|Spirochaetes	L	Pfam:DUF342	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
WZS1_k127_5581356_2	318161.Sden_3424	5.511e-118	404.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q8ZG@267890|Shewanellaceae	1236|Gammaproteobacteria	T	Two component regulator three Y domain protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9,Reg_prop,Y_Y_Y
WZS1_k127_5581356_7	889378.Spiaf_0510	6.035e-47	179.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,DsbD,Redoxin,Thioredoxin_8
WZS1_k127_5581356_1	903818.KI912268_gene810	6.851e-218	683.0	COG1350@1|root,COG1350@2|Bacteria,3Y7FQ@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WZS1_k127_5581356_5	1122963.AUHB01000001_gene349	2.378e-79	272.0	COG1349@1|root,COG1349@2|Bacteria,1MXW2@1224|Proteobacteria,2UCPD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
WZS1_k127_5581356_8	1434325.AZQN01000007_gene3200	1.718e-40	154.0	COG0494@1|root,COG0494@2|Bacteria,4NR26@976|Bacteroidetes,47QYB@768503|Cytophagia	976|Bacteroidetes	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5581356_6	1249997.JHZW01000003_gene3231	1.094e-66	233.0	COG0494@1|root,COG0494@2|Bacteria,4NHER@976|Bacteroidetes,1HWUJ@117743|Flavobacteriia,2PGJN@252356|Maribacter	976|Bacteroidetes	L	NUDIX domain	nudK	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
WZS1_k127_5581356_3	889378.Spiaf_2343	8.33e-100	334.0	COG0583@1|root,COG0583@2|Bacteria,2J958@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
WZS1_k127_5581356_0	1480694.DC28_07945	1.108e-258	803.0	COG0065@1|root,COG0065@2|Bacteria,2J9J7@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
WZS1_k127_5581356_4	889378.Spiaf_2345	5.568e-89	297.0	COG0066@1|root,COG0066@2|Bacteria,2JACS@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
WZS1_k127_5581576_7	1480694.DC28_14290	4.186e-53	188.0	COG0096@1|root,COG0096@2|Bacteria,2J7SM@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
WZS1_k127_5581576_13	889378.Spiaf_0567	1.125e-28	115.0	COG0199@1|root,COG0199@2|Bacteria,2J8U1@203691|Spirochaetes	203691|Spirochaetes	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
WZS1_k127_5581576_4	1123274.KB899411_gene3101	4.186e-79	267.0	COG0094@1|root,COG0094@2|Bacteria,2J5DT@203691|Spirochaetes	203691|Spirochaetes	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
WZS1_k127_5581576_12	573413.Spirs_0966	7.544e-33	129.0	COG0198@1|root,COG0198@2|Bacteria,2J809@203691|Spirochaetes	203691|Spirochaetes	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
WZS1_k127_5581576_5	545694.TREPR_1487	3.655e-60	209.0	COG0093@1|root,COG0093@2|Bacteria,2J7N1@203691|Spirochaetes	203691|Spirochaetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
WZS1_k127_5581576_11	760011.Spico_1707	1.148e-33	131.0	COG0186@1|root,COG0186@2|Bacteria,2J8JX@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
WZS1_k127_5581576_15	1302858.I871_02575	2.435e-13	72.0	COG0255@1|root,COG0255@2|Bacteria,2J96Q@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
WZS1_k127_5581576_6	573413.Spirs_0962	5.798e-54	194.0	COG0197@1|root,COG0197@2|Bacteria,2J83F@203691|Spirochaetes	203691|Spirochaetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
WZS1_k127_5581576_1	760011.Spico_1710	4.145e-105	345.0	COG0092@1|root,COG0092@2|Bacteria,2J5AK@203691|Spirochaetes	203691|Spirochaetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
WZS1_k127_5581576_10	412419.BDU_486	5.843e-41	154.0	COG0091@1|root,COG0091@2|Bacteria,2J7KV@203691|Spirochaetes	203691|Spirochaetes	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
WZS1_k127_5581576_8	744872.Spica_0389	4.765e-44	161.0	COG0185@1|root,COG0185@2|Bacteria,2J8DX@203691|Spirochaetes	203691|Spirochaetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
WZS1_k127_5581576_0	1307761.L21SP2_0880	2.331e-124	403.0	COG0090@1|root,COG0090@2|Bacteria,2J5G3@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WZS1_k127_5581576_14	573413.Spirs_0957	2.283e-24	105.0	COG0089@1|root,COG0089@2|Bacteria,2J85B@203691|Spirochaetes	203691|Spirochaetes	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
WZS1_k127_5581576_3	573413.Spirs_0956	4.064e-82	278.0	COG0088@1|root,COG0088@2|Bacteria,2J5NS@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
WZS1_k127_5581576_2	744872.Spica_0385	2.377e-82	278.0	COG0087@1|root,COG0087@2|Bacteria,2J633@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
WZS1_k127_5581576_9	1480694.DC28_14360	3.937e-41	152.0	COG0051@1|root,COG0051@2|Bacteria,2J7XK@203691|Spirochaetes	203691|Spirochaetes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
WZS1_k127_5585832_3	1123274.KB899419_gene1958	1.418e-50	183.0	COG1394@1|root,COG1394@2|Bacteria,2J59S@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
WZS1_k127_5585832_2	573413.Spirs_2456	2.794e-127	429.0	COG1269@1|root,COG1269@2|Bacteria,2J594@203691|Spirochaetes	203691|Spirochaetes	C	V-type ATP synthase, subunit I	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
WZS1_k127_5585832_4	573413.Spirs_2455	3.374e-44	165.0	COG0636@1|root,COG0636@2|Bacteria,2J7GW@203691|Spirochaetes	203691|Spirochaetes	C	ATP synthase subunit K	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
WZS1_k127_5585832_5	1313294.BPA_0062100	3.804e-15	87.0	292GV@1|root,2ZQ11@2|Bacteria,2J7RA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5585832_0	744872.Spica_1225	0.0	1362.0	COG0178@1|root,COG0178@2|Bacteria,2J5BN@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
WZS1_k127_5585832_1	889378.Spiaf_1638	1.598e-134	471.0	COG1452@1|root,COG1452@2|Bacteria,2J5EC@203691|Spirochaetes	203691|Spirochaetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5585832_6	1480694.DC28_00390	4.872e-05	46.0	COG1702@1|root,COG1702@2|Bacteria,2J64H@203691|Spirochaetes	203691|Spirochaetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
WZS1_k127_5587162_0	1480694.DC28_08505	2.414e-184	593.0	COG2114@1|root,COG2114@2|Bacteria,2J77D@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
WZS1_k127_5587162_2	573413.Spirs_0348	2.848e-68	238.0	COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes	203691|Spirochaetes	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
WZS1_k127_5587162_1	1122947.FR7_4229	6.353e-70	239.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4H223@909932|Negativicutes	909932|Negativicutes	E	ABC transporter, ATP-binding protein	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
WZS1_k127_5591243_2	744872.Spica_1315	1.086e-62	230.0	COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
WZS1_k127_5591243_3	1121403.AUCV01000001_gene815	4.276e-26	110.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MKNN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
WZS1_k127_5591243_0	665571.STHERM_c12610	4.182e-278	874.0	COG0542@1|root,COG0542@2|Bacteria,2J6BU@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
WZS1_k127_5591243_1	1121904.ARBP01000005_gene4821	5.466e-74	256.0	COG2360@1|root,COG2360@2|Bacteria,4NG3A@976|Bacteroidetes,47MA5@768503|Cytophagia	976|Bacteroidetes	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
WZS1_k127_5591243_4	383372.Rcas_3076	1.328e-09	67.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,2GBI0@200795|Chloroflexi,3766M@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
WZS1_k127_559615_0	1279009.ADICEAN_00942	1.199e-78	272.0	COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,47KYC@768503|Cytophagia	976|Bacteroidetes	M	penicillin-binding protein 1C	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
WZS1_k127_559615_1	1499967.BAYZ01000032_gene1132	1.617e-16	80.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
WZS1_k127_55983_3	1123236.KB899394_gene3183	1.285e-104	357.0	COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,1RR24@1236|Gammaproteobacteria,46764@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG0168 Trk-type K transport systems, membrane components	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
WZS1_k127_55983_6	545694.TREPR_0145	8.823e-53	197.0	COG0349@1|root,COG0349@2|Bacteria,2J80E@203691|Spirochaetes	203691|Spirochaetes	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
WZS1_k127_55983_0	1120972.AUMH01000016_gene2235	4.007e-150	490.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4HBHZ@91061|Bacilli	91061|Bacilli	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
WZS1_k127_55983_7	1449080.JQMV01000003_gene1765	9.462e-30	125.0	COG0703@1|root,COG0703@2|Bacteria,1WI00@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
WZS1_k127_55983_4	225937.HP15_982	2.462e-83	303.0	COG1305@1|root,COG1305@2|Bacteria,1R5Q7@1224|Proteobacteria,1RPH2@1236|Gammaproteobacteria,465FR@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
WZS1_k127_55983_5	889378.Spiaf_2509	6.347e-55	203.0	28N6F@1|root,30YAD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_55983_2	1307761.L21SP2_3064	3.83e-110	379.0	COG2114@1|root,COG2114@2|Bacteria,2J6HA@203691|Spirochaetes	203691|Spirochaetes	T	Guanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,Guanylate_cyc
WZS1_k127_55983_1	573413.Spirs_3758	5.999e-119	398.0	COG0621@1|root,COG0621@2|Bacteria,2J5PM@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
WZS1_k127_55983_8	906968.Trebr_1122	3.429e-10	65.0	2BVQY@1|root,2ZNAN@2|Bacteria,2JAY1@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5607581_0	366602.Caul_4630	1.446e-53	198.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,2KFT7@204458|Caulobacterales	204458|Caulobacterales	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
WZS1_k127_5607581_1	573413.Spirs_1051	4.267e-32	136.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HAMP,HATPase_c,HisKA,PAS,dCache_3
WZS1_k127_5611950_1	1499967.BAYZ01000152_gene1403	9.355e-61	219.0	COG4942@1|root,COG4942@2|Bacteria	2|Bacteria	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
WZS1_k127_5616425_1	926692.AZYG01000034_gene2372	2.081e-80	278.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WAED@53433|Halanaerobiales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
WZS1_k127_5616425_5	1121422.AUMW01000002_gene2247	4.483e-52	191.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,260I1@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
WZS1_k127_5616425_2	1329516.JPST01000028_gene3374	2.861e-60	216.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,4H9PW@91061|Bacilli,27B3W@186824|Thermoactinomycetaceae	91061|Bacilli	H	GTP cyclohydrolase II	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08945	DHBP_synthase,GTP_cyclohydro2
WZS1_k127_5616425_3	1294265.JCM21738_4998	5.871e-60	212.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli,1ZFJ6@1386|Bacillus	91061|Bacilli	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08940	DMRL_synthase
WZS1_k127_5616425_6	1298593.TOL_3271	2.363e-33	138.0	COG4106@1|root,COG4106@2|Bacteria,1QUFH@1224|Proteobacteria,1T1X5@1236|Gammaproteobacteria,1XJS5@135619|Oceanospirillales	135619|Oceanospirillales	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
WZS1_k127_5616425_4	485913.Krac_8168	4.577e-56	207.0	COG2746@1|root,COG2746@2|Bacteria,2G6YM@200795|Chloroflexi	200795|Chloroflexi	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
WZS1_k127_5616425_0	1307761.L21SP2_1902	2.843e-90	300.0	COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
WZS1_k127_5620976_3	4113.PGSC0003DMT400013896	3.369e-12	68.0	2C8JP@1|root,2R2CK@2759|Eukaryota,38198@33090|Viridiplantae,3GQKH@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5620976_6	13333.ERM96664	0.0003504	43.0	COG0090@1|root,KOG0438@2759|Eukaryota,37U0V@33090|Viridiplantae,3GI5P@35493|Streptophyta	35493|Streptophyta	J	Ribosomal protein L2	-	GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	-	-	-	-	-	-	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WZS1_k127_5620976_4	4096.XP_009800571.1	2.158e-08	58.0	2D1YF@1|root,2SE0I@2759|Eukaryota,37XYT@33090|Viridiplantae,3GMTA@35493|Streptophyta,44T8R@71274|asterids	35493|Streptophyta	O	Ring finger	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5620976_0	3988.XP_002535312.1	6.848e-293	904.0	COG0197@1|root,KOG3422@2759|Eukaryota,38965@33090|Viridiplantae,3GY34@35493|Streptophyta,4JV2J@91835|fabids	35493|Streptophyta	J	RIBOSOMAL protein	-	-	-	ko:K02878,ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16,Ribosomal_S3_C
WZS1_k127_5620976_2	4081.Solyc01g007480.1.1	4.628e-20	90.0	2D6K7@1|root,2T29T@2759|Eukaryota,381ST@33090|Viridiplantae,3GRXI@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_564_0	1123274.KB899436_gene1284	9.327e-61	230.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
WZS1_k127_564_1	291112.PAU_01476	2.826e-17	96.0	COG3210@1|root,COG3210@2|Bacteria,1NZHP@1224|Proteobacteria,1SQ1C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5681164_20	102107.XP_008222395.1	0.0006591	45.0	COG2801@1|root,KOG0017@2759|Eukaryota,37R6P@33090|Viridiplantae,3G8BW@35493|Streptophyta,4JN0G@91835|fabids	35493|Streptophyta	L	Uncharacterized protein K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,rve
WZS1_k127_5681164_1	72664.XP_006398028.1	3.877e-80	269.0	COG0197@1|root,KOG3422@2759|Eukaryota,37TB9@33090|Viridiplantae,3GGF9@35493|Streptophyta	35493|Streptophyta	J	RIBOSOMAL protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019843,GO:0032543,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
WZS1_k127_5681164_19	29760.VIT_12s0121g00310.t01	2.735e-05	50.0	COG0515@1|root,KOG1187@2759|Eukaryota,37JQ5@33090|Viridiplantae,3GEWF@35493|Streptophyta	35493|Streptophyta	T	Belongs to the protein kinase superfamily. Ser Thr protein kinase family	-	-	2.7.10.1,2.7.11.1	ko:K13416	ko04016,ko04075,ko04626,map04016,map04075,map04626	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	LRRNT_2,LRR_1,LRR_8,Pkinase
WZS1_k127_5681164_5	3656.XP_008460624.1	1.017e-27	113.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RIF@33090|Viridiplantae,3G9AM@35493|Streptophyta,4JTRP@91835|fabids	35493|Streptophyta	L	cysteine-rich RLK (RECEPTOR-like protein kinase) 8	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,Retrotran_gag_3,Retrotrans_gag,gag_pre-integrs,rve
WZS1_k127_5681164_13	3750.XP_008356535.1	1.455e-10	62.0	COG2801@1|root,KOG0017@2759|Eukaryota	3750.XP_008356535.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5681164_4	3750.XP_008376990.1	7.638e-34	133.0	COG2801@1|root,KOG0017@2759|Eukaryota	3750.XP_008376990.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5681164_14	3750.XP_008359376.1	3.295e-10	63.0	COG2801@1|root,KOG0017@2759|Eukaryota	3750.XP_008359376.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5681164_18	38727.Pavir.Aa02971.1.p	8.247e-06	51.0	KOG1835@1|root,KOG1835@2759|Eukaryota,37IXG@33090|Viridiplantae,3G92H@35493|Streptophyta,3KR2A@4447|Liliopsida,3I3ET@38820|Poales	35493|Streptophyta	S	Nuclear pore complex scaffold, nucleoporins 186/192/205	-	GO:0003674,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005643,GO:0005737,GO:0006810,GO:0006913,GO:0006996,GO:0006997,GO:0006999,GO:0008150,GO:0009507,GO:0009536,GO:0009987,GO:0012505,GO:0016043,GO:0017056,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044611,GO:0046907,GO:0051169,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0071840	-	ko:K14310	ko03013,map03013	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko03036	1.I.1	-	-	Nup192
WZS1_k127_5681164_6	3750.XP_008341155.1	1.205e-24	105.0	COG0515@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG1187@2759|Eukaryota	2759|Eukaryota	KLT	protein serine/threonine kinase activity	-	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004675,GO:0004888,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019199,GO:0019538,GO:0023052,GO:0036211,GO:0038023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.11.1	ko:K04733	ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Pkinase,Pkinase_Tyr
WZS1_k127_5681164_0	72664.XP_006409508.1	2.954e-121	392.0	COG0852@1|root,KOG1713@2759|Eukaryota,37SXR@33090|Viridiplantae,3GGAU@35493|Streptophyta,3HWPR@3699|Brassicales	35493|Streptophyta	C	Belongs to the complex I 30 kDa subunit family	nad9	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3,1.6.99.3	ko:K03936	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1.6	-	-	Complex1_30kDa
WZS1_k127_5681164_2	3827.XP_004500360.1	1.755e-67	235.0	2A7BJ@1|root,2RYDW@2759|Eukaryota,37U5M@33090|Viridiplantae,3GHQH@35493|Streptophyta	35493|Streptophyta	S	RIBOSOMAL protein	rps1	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
WZS1_k127_5681164_10	3880.AES58577	2.911e-13	72.0	COG0056@1|root,COG0356@1|root,COG1622@1|root,KOG1353@2759|Eukaryota,KOG4665@2759|Eukaryota,KOG4767@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta,4JSJY@91835|fabids	35493|Streptophyta	C	ATP synthase	atp1	-	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,COX2_TM
WZS1_k127_5681164_3	3880.AES58577	1.831e-44	161.0	COG0056@1|root,COG0356@1|root,COG1622@1|root,KOG1353@2759|Eukaryota,KOG4665@2759|Eukaryota,KOG4767@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta,4JSJY@91835|fabids	35493|Streptophyta	C	ATP synthase	atp1	-	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,COX2_TM
WZS1_k127_5690371_0	906968.Trebr_1484	1.595e-123	427.0	COG0666@1|root,COG0666@2|Bacteria,2J5FX@203691|Spirochaetes	203691|Spirochaetes	S	Ankyrin repeat	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
WZS1_k127_5690371_1	1121904.ARBP01000012_gene1343	1.433e-39	151.0	COG0139@1|root,COG0139@2|Bacteria,4NERE@976|Bacteroidetes,47KYT@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the PRA-CH family	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
WZS1_k127_5693552_1	744872.Spica_1285	8.781e-126	410.0	COG1234@1|root,COG1234@2|Bacteria,2J6E7@203691|Spirochaetes	203691|Spirochaetes	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
WZS1_k127_5693552_0	443254.Marpi_1839	3.21e-201	642.0	COG0513@1|root,COG0513@2|Bacteria,2GC3A@200918|Thermotogae	200918|Thermotogae	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
WZS1_k127_5693552_3	889378.Spiaf_0614	1.52e-77	276.0	COG0664@1|root,COG2172@1|root,COG0664@2|Bacteria,COG2172@2|Bacteria,2J5ZY@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,cNMP_binding
WZS1_k127_5693552_4	1157490.EL26_16535	5.513e-59	217.0	COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,4HARN@91061|Bacilli,278XN@186823|Alicyclobacillaceae	91061|Bacilli	S	Cobalamin synthesis protein cobW C-terminal domain	yjiA	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
WZS1_k127_5693552_5	1313292.BCO_0092600	1.141e-28	121.0	COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes	203691|Spirochaetes	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
WZS1_k127_5693552_2	596324.TREVI0001_0566	1.466e-111	378.0	COG2183@1|root,COG2183@2|Bacteria,2J5G8@203691|Spirochaetes	203691|Spirochaetes	K	Tex-like protein	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
WZS1_k127_5693697_3	573413.Spirs_0325	4.764e-126	413.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5693697_17	1123274.KB899407_gene181	1.893e-05	50.0	2ET9B@1|root,33KTC@2|Bacteria,2J9AB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5693697_10	1480694.DC28_09945	1.799e-37	147.0	COG0597@1|root,COG0597@2|Bacteria,2J7QV@203691|Spirochaetes	203691|Spirochaetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
WZS1_k127_5693697_5	1480694.DC28_09940	1.114e-81	280.0	COG0327@1|root,COG0327@2|Bacteria,2J6QQ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM dinuclear metal center protein, YbgI SA1388 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
WZS1_k127_5693697_0	573413.Spirs_0321	1.668e-212	686.0	COG0606@1|root,COG1067@1|root,COG0606@2|Bacteria,COG1067@2|Bacteria,2J6SU@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
WZS1_k127_5693697_2	1307761.L21SP2_0140	3.229e-142	466.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
WZS1_k127_5693697_9	665571.STHERM_c01630	7.568e-38	151.0	COG0566@1|root,COG0566@2|Bacteria,2J6AD@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
WZS1_k127_5693697_16	1501230.ET33_09420	3.218e-09	68.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,4H9TR@91061|Bacilli,26R4V@186822|Paenibacillaceae	91061|Bacilli	C	Dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
WZS1_k127_5693697_15	889378.Spiaf_0222	4.548e-17	84.0	2DFDU@1|root,2ZRHI@2|Bacteria,2J8SZ@203691|Spirochaetes	203691|Spirochaetes	S	factor, FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
WZS1_k127_5693697_4	573413.Spirs_0315	1.181e-84	287.0	COG0313@1|root,COG0313@2|Bacteria,2J5DW@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
WZS1_k127_5693697_14	1123274.KB899407_gene190	4.235e-18	89.0	292V4@1|root,2ZE4M@2|Bacteria,2JBFU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5693697_12	867900.Celly_2740	7.203e-30	127.0	298QN@1|root,2ZVV0@2|Bacteria,4NNRX@976|Bacteroidetes,1I2A6@117743|Flavobacteriia,1F9BG@104264|Cellulophaga	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5693697_7	889378.Spiaf_0278	2.248e-74	261.0	COG2055@1|root,COG2055@2|Bacteria,2JAQP@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.130	ko:K08092	ko00040,ko00053,map00040,map00053	-	R02637,R02639	RC00238	ko00000,ko00001,ko01000	-	-	-	Ldh_2
WZS1_k127_5693697_6	744872.Spica_1642	1.11e-75	265.0	COG2114@1|root,COG2114@2|Bacteria,2J9VX@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5693697_13	573413.Spirs_3788	1.516e-28	128.0	COG2114@1|root,COG2114@2|Bacteria,2JAZ7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5693697_11	1121434.AULY01000006_gene522	3.883e-31	132.0	COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria,42TNE@68525|delta/epsilon subdivisions,2WQI7@28221|Deltaproteobacteria,2MCG3@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
WZS1_k127_5693697_1	267608.RSc0539	6.254e-150	488.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae	28216|Betaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
WZS1_k127_5693697_8	710696.Intca_2231	4.44e-45	181.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4FF2D@85021|Intrasporangiaceae	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
WZS1_k127_5700106_0	1480694.DC28_10300	3.572e-83	281.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
WZS1_k127_5700106_3	1307761.L21SP2_2197	3.327e-25	105.0	COG1773@1|root,COG1773@2|Bacteria,2J8V4@203691|Spirochaetes	203691|Spirochaetes	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
WZS1_k127_5700106_2	744872.Spica_0678	6.052e-50	185.0	COG0860@1|root,COG0860@2|Bacteria,2J7PV@203691|Spirochaetes	203691|Spirochaetes	M	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase
WZS1_k127_5700106_6	1289135.A966_06335	2.116e-07	58.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
WZS1_k127_5700106_1	573413.Spirs_3692	4.966e-66	232.0	COG2344@1|root,COG2344@2|Bacteria,2J89C@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
WZS1_k127_5700106_4	1123274.KB899427_gene3300	2.009e-21	101.0	2FGX3@1|root,348SD@2|Bacteria,2J7PZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5700106_5	1280390.CBQR020000077_gene1668	6.294e-20	94.0	COG0457@1|root,COG0457@2|Bacteria,1V512@1239|Firmicutes,4HU0V@91061|Bacilli,26WZ7@186822|Paenibacillaceae	91061|Bacilli	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_4
WZS1_k127_5701542_7	44060.JODL01000010_gene1670	4.41e-20	94.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,2GKK1@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3372,PUD
WZS1_k127_5701542_5	595494.Tola_1754	6.582e-90	306.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1Y61V@135624|Aeromonadales	135624|Aeromonadales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
WZS1_k127_5701542_2	1480694.DC28_02865	1.914e-158	535.0	COG0642@1|root,COG2205@2|Bacteria	1480694.DC28_02865|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5701542_4	889378.Spiaf_0710	1.16e-107	360.0	COG2199@1|root,COG3706@2|Bacteria,2J7V5@203691|Spirochaetes	203691|Spirochaetes	T	response	rrp-1	-	-	ko:K18444	ko02020,map02020	M00662	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GGDEF,Hpt,Response_reg
WZS1_k127_5701542_6	665571.STHERM_c16670	5.014e-62	221.0	COG0120@1|root,COG0120@2|Bacteria,2J575@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
WZS1_k127_5701542_1	573413.Spirs_3699	1.456e-222	700.0	COG1384@1|root,COG1384@2|Bacteria,2J5WX@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f,tRNA-synt_1g
WZS1_k127_5701542_0	1499967.BAYZ01000032_gene1131	0.0	1451.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
WZS1_k127_5701542_3	1499967.BAYZ01000032_gene1132	4.609e-129	426.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
WZS1_k127_5701644_3	322710.Avin_21190	2.813e-60	221.0	COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	entF	-	-	ko:K15653	ko01053,map01053	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
WZS1_k127_5701644_1	1349767.GJA_3092	1.224e-113	373.0	COG1535@1|root,COG3433@1|root,COG1535@2|Bacteria,COG3433@2|Bacteria,1MW2U@1224|Proteobacteria,2VQXQ@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Isochorismatase family	-	-	3.3.2.1,3.3.2.15,6.3.2.14	ko:K01252,ko:K20261	ko00405,ko01053,ko01110,ko01130,ko02024,map00405,map01053,map01110,map01130,map02024	M00835	R03037,R07644,R11463	RC00162,RC00350,RC02148,RC03046	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Isochorismatase,PP-binding
WZS1_k127_5701644_0	1349767.GJA_3093	5.834e-241	756.0	COG1021@1|root,COG1021@2|Bacteria,1NSN8@1224|Proteobacteria,2VJ76@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	AMP-binding enzyme C-terminal domain	entE	-	2.7.7.58,6.3.2.14	ko:K02363,ko:K12238	ko01053,ko01110,ko01130,map01053,map01110,map01130	-	R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C
WZS1_k127_5701644_2	322710.Avin_21220	2.315e-100	332.0	COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,1RRBX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	HQ	Isochorismate synthase	entC	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008909,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016853,GO:0016866,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	5.4.4.2	ko:K01851,ko:K02361	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_0585,iECIAI1_1343.ECIAI1_0577,iECO103_1326.ECO103_0601,iECO111_1330.ECO111_0623,iECO26_1355.ECO26_0668,iECW_1372.ECW_m0648,iEKO11_1354.EKO11_3272,iEcE24377_1341.EcE24377A_0613,iSbBS512_1146.SbBS512_E0495,iUMNK88_1353.UMNK88_626,iWFL_1372.ECW_m0648	Chorismate_bind
WZS1_k127_571048_0	744872.Spica_1067	5.09e-15	91.0	COG1196@1|root,COG3210@1|root,COG1196@2|Bacteria,COG3210@2|Bacteria,2J8QW@203691|Spirochaetes	203691|Spirochaetes	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5727900_2	42345.XP_008778480.1	3.453e-05	46.0	COG2801@1|root,KOG0017@2759|Eukaryota,383PG@33090|Viridiplantae,3GUZH@35493|Streptophyta,3M5MZ@4447|Liliopsida	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
WZS1_k127_5727900_0	4081.Solyc11g062200.1.1	5.311e-29	118.0	COG2801@1|root,KOG0017@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta,44UC5@71274|asterids	35493|Streptophyta	L	Mitochondrial protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,Retrotran_gag_3,Retrotrans_gag,gag_pre-integrs,rve,zf-CCHC
WZS1_k127_5727900_1	4432.XP_010244415.1	9.651e-07	52.0	COG2801@1|root,KOG0017@2759|Eukaryota,37NGF@33090|Viridiplantae,3GGSM@35493|Streptophyta	35493|Streptophyta	G	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5738857_0	86416.Clopa_3943	1.252e-161	523.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,36EQD@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_N,Malt_amylase_C
WZS1_k127_5738857_1	877418.ATWV01000004_gene1870	6.212e-48	179.0	COG0810@1|root,COG0810@2|Bacteria,2J8E6@203691|Spirochaetes	203691|Spirochaetes	M	TonB protein	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
WZS1_k127_5743556_1	164328.Phyra87617	5.619e-07	53.0	COG2801@1|root,KOG0017@2759|Eukaryota,3QIT9@4776|Peronosporales	4776|Peronosporales	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5743556_2	15368.BRADI2G06305.1	2.544e-06	52.0	COG2801@1|root,KOG0017@2759|Eukaryota,37V5Q@33090|Viridiplantae,3GFFK@35493|Streptophyta,3M7B5@4447|Liliopsida,3IKJW@38820|Poales	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,Retrotran_gag_3,gag_pre-integrs,rve,zf-CCHC
WZS1_k127_5743556_0	15368.BRADI3G60275.1	1.642e-08	58.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RIF@33090|Viridiplantae,3GBWZ@35493|Streptophyta	35493|Streptophyta	L	cysteine-rich RLK (RECEPTOR-like protein kinase) 8	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,Retrotran_gag_3,Retrotrans_gag,gag_pre-integrs,rve
WZS1_k127_5746266_0	873517.HMPREF1977_1004	1.001e-26	114.0	2E6GM@1|root,32XVA@2|Bacteria,4NSW1@976|Bacteroidetes,1I4W0@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5746967_1	665571.STHERM_c13090	7.292e-68	236.0	COG0020@1|root,COG0020@2|Bacteria,2J5Y6@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
WZS1_k127_5746967_2	314723.BH0119	2.171e-49	186.0	COG4589@1|root,COG4589@2|Bacteria,2J7JM@203691|Spirochaetes	203691|Spirochaetes	S	Phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
WZS1_k127_5746967_0	545695.TREAZ_0623	4.47e-82	290.0	COG0750@1|root,COG0750@2|Bacteria,2J616@203691|Spirochaetes	203691|Spirochaetes	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
WZS1_k127_5746967_3	573413.Spirs_2871	1.878e-23	107.0	2AMCR@1|root,31C85@2|Bacteria,2J6BE@203691|Spirochaetes	203691|Spirochaetes	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
WZS1_k127_575165_0	573413.Spirs_1327	0.0	1176.0	COG0587@1|root,COG0587@2|Bacteria,2J5B5@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
WZS1_k127_5760952_0	1227739.Hsw_4220	4.85e-211	672.0	COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,47JQH@768503|Cytophagia	976|Bacteroidetes	G	Alpha amylase, catalytic domain	amyA2	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,tRNA_SAD
WZS1_k127_5760952_1	264462.Bd0909	2.346e-28	119.0	COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria	1224|Proteobacteria	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
WZS1_k127_5760952_3	395494.Galf_1463	8.968e-05	50.0	COG1396@1|root,COG1396@2|Bacteria,1NEGW@1224|Proteobacteria,2VVWZ@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
WZS1_k127_5760952_2	1123057.P872_20375	2.603e-21	102.0	2C85A@1|root,32801@2|Bacteria,4NS08@976|Bacteroidetes,47QWI@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5763922_4	390236.BafPKo_0106	0.0001992	50.0	COG0760@1|root,COG0760@2|Bacteria,2J6I2@203691|Spirochaetes	203691|Spirochaetes	M	peptidylprolyl isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
WZS1_k127_5763922_3	665571.STHERM_c09830	2.681e-17	88.0	COG0716@1|root,COG0716@2|Bacteria,2J892@203691|Spirochaetes	203691|Spirochaetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5763922_2	744872.Spica_1824	1.374e-21	98.0	COG1314@1|root,COG1314@2|Bacteria,2J7UR@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
WZS1_k127_5763922_1	545695.TREAZ_3384	1.909e-93	312.0	COG0126@1|root,COG0149@1|root,COG0126@2|Bacteria,COG0149@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
WZS1_k127_5763922_0	754027.HMPREF9554_01191	1.731e-195	615.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
WZS1_k127_5772927_1	1480694.DC28_13380	3.407e-11	70.0	28UTT@1|root,2ZGXY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5772927_0	889378.Spiaf_0209	1.25e-26	118.0	COG4254@1|root,COG4254@2|Bacteria,2J6X7@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
WZS1_k127_5781032_2	1190603.AJYD01000015_gene983	1.158e-24	106.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1MWTF@1224|Proteobacteria,1RQMF@1236|Gammaproteobacteria,1Y2US@135623|Vibrionales	135623|Vibrionales	K	Bacterial transcription activator, effector binding domain	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
WZS1_k127_5781032_1	696281.Desru_1437	3.511e-62	220.0	2C388@1|root,30ZIR@2|Bacteria,1V245@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5781032_3	498211.CJA_2261	1.151e-10	65.0	COG1670@1|root,COG1670@2|Bacteria,1RKKE@1224|Proteobacteria,1S47R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
WZS1_k127_5781032_0	906968.Trebr_0416	1.239e-88	309.0	COG0534@1|root,COG0534@2|Bacteria,2J674@203691|Spirochaetes	203691|Spirochaetes	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
WZS1_k127_5781032_4	502025.Hoch_5834	1.549e-09	64.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,42TKC@68525|delta/epsilon subdivisions,2WQ16@28221|Deltaproteobacteria,2YWBJ@29|Myxococcales	28221|Deltaproteobacteria	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
WZS1_k127_5785856_1	1123274.KB899435_gene1307	4.035e-24	113.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2J5T7@203691|Spirochaetes	203691|Spirochaetes	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
WZS1_k127_5785856_0	573413.Spirs_2624	6.55e-72	258.0	2CK99@1|root,3464J@2|Bacteria,2J60S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5785856_2	1539298.JO41_06845	3.459e-11	68.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
WZS1_k127_5787360_3	744872.Spica_1397	1.704e-43	163.0	COG1235@1|root,COG1235@2|Bacteria,2J5C5@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
WZS1_k127_5787360_0	573413.Spirs_2081	1.053e-306	985.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
WZS1_k127_5787360_1	573413.Spirs_2080	1.241e-79	278.0	COG1559@1|root,COG1559@2|Bacteria,2J5V4@203691|Spirochaetes	203691|Spirochaetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
WZS1_k127_5787360_2	573413.Spirs_2079	1.77e-72	251.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
WZS1_k127_5791440_8	1123274.KB899419_gene1882	1.148e-19	92.0	COG1551@1|root,COG1551@2|Bacteria,2J8VE@203691|Spirochaetes	203691|Spirochaetes	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
WZS1_k127_5791440_6	665571.STHERM_c07640	6.604e-41	155.0	COG1699@1|root,COG1699@2|Bacteria,2J7ZU@203691|Spirochaetes	203691|Spirochaetes	N	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
WZS1_k127_5791440_2	1307761.L21SP2_1229	1.068e-132	434.0	COG1344@1|root,COG1344@2|Bacteria,2J6BJ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein 3	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
WZS1_k127_5791440_0	665571.STHERM_c07620	8.9e-238	750.0	COG1256@1|root,COG1256@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
WZS1_k127_5791440_9	889378.Spiaf_0793	2.908e-12	73.0	28UHW@1|root,2ZGNJ@2|Bacteria,2J8AR@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
WZS1_k127_5791440_3	880073.Calab_0212	2.925e-60	217.0	COG0596@1|root,COG0596@2|Bacteria,2NQV9@2323|unclassified Bacteria	2|Bacteria	S	Alpha/beta hydrolase family	ybfF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689	-	ko:K01175	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
WZS1_k127_5791440_5	545694.TREPR_3857	1.922e-44	179.0	COG0457@1|root,COG0457@2|Bacteria,2J8BT@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
WZS1_k127_5791440_1	1123274.KB899419_gene1876	8.007e-155	507.0	COG1472@1|root,COG1472@2|Bacteria,2J5CS@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolase family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
WZS1_k127_5791440_7	1123274.KB899419_gene1875	1.035e-29	130.0	COG3393@1|root,COG3393@2|Bacteria,2J84J@203691|Spirochaetes	203691|Spirochaetes	S	Acetyltransferase GNAT family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
WZS1_k127_5791440_4	754027.HMPREF9554_00107	1.241e-51	186.0	COG0448@1|root,COG0448@2|Bacteria,2J5UB@203691|Spirochaetes	203691|Spirochaetes	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WZS1_k127_5797159_0	394503.Ccel_0861	1.188e-258	831.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_5797159_1	1196323.ALKF01000138_gene3468	2.173e-114	389.0	COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae	91061|Bacilli	Q	Polyketide synthase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_5797796_0	573413.Spirs_1641	1.603e-214	675.0	COG0493@1|root,COG0493@2|Bacteria,2J5FP@203691|Spirochaetes	203691|Spirochaetes	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
WZS1_k127_5797796_1	1123274.KB899422_gene49	8.756e-60	216.0	COG1235@1|root,COG1235@2|Bacteria,2JAK8@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
WZS1_k127_5797796_3	945713.IALB_2715	2.009e-16	84.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC1	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC,Glutaredoxin
WZS1_k127_5797796_2	545695.TREAZ_3624	7.883e-48	179.0	COG0084@1|root,COG0084@2|Bacteria,2J7J9@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WZS1_k127_5799171_0	889378.Spiaf_2184	9.758e-118	384.0	COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
WZS1_k127_5799171_4	751945.Theos_0271	2.971e-11	74.0	COG1470@1|root,COG3895@1|root,COG1470@2|Bacteria,COG3895@2|Bacteria,1WIA5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,PEGA
WZS1_k127_5799171_3	545695.TREAZ_0666	1.695e-65	242.0	2F1XI@1|root,33UX3@2|Bacteria,2J59N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5799171_2	1480694.DC28_06325	6.813e-69	243.0	COG0561@1|root,COG0561@2|Bacteria,2J5FZ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
WZS1_k127_5799171_1	882.DVU_1190	9.167e-93	318.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2MAJV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_8,PAS_9
WZS1_k127_5823250_1	1480694.DC28_03250	7.774e-09	56.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
WZS1_k127_5823250_0	545695.TREAZ_2700	1.434e-13	83.0	2BYRX@1|root,2ZIX1@2|Bacteria,2J60M@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5827188_0	667014.Thein_0029	2.585e-111	369.0	COG0161@1|root,COG0161@2|Bacteria,2GIFS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Aminotransferase class-III	-	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WZS1_k127_5827188_1	1123371.ATXH01000023_gene918	3.382e-96	328.0	COG0156@1|root,COG0156@2|Bacteria,2GI7N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Aminotransferase class I and II	-	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_5827188_3	411477.PARMER_04113	5.66e-34	146.0	COG2830@1|root,COG2830@2|Bacteria,4NSQK@976|Bacteroidetes,2FTTG@200643|Bacteroidia,22YIE@171551|Porphyromonadaceae	976|Bacteroidetes	S	Protein of unknown function (DUF452)	-	-	3.1.1.85	ko:K09789	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF452
WZS1_k127_5827188_2	470.IX87_18370	4.464e-38	153.0	COG4106@1|root,COG4106@2|Bacteria,1N1SE@1224|Proteobacteria,1S97U@1236|Gammaproteobacteria,3NJ8J@468|Moraxellaceae	1236|Gammaproteobacteria	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
WZS1_k127_5827981_1	1499967.BAYZ01000152_gene1403	2.105e-21	101.0	COG4942@1|root,COG4942@2|Bacteria	2|Bacteria	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
WZS1_k127_5827981_0	1499967.BAYZ01000078_gene995	7.086e-107	358.0	COG4913@1|root,COG4913@2|Bacteria	2|Bacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
WZS1_k127_5839648_7	272563.CD630_30750	1.159e-18	91.0	COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,248V6@186801|Clostridia,25SIZ@186804|Peptostreptococcaceae	186801|Clostridia	G	PTS system, Lactose/Cellobiose specific IIB subunit	-	-	2.7.1.202	ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
WZS1_k127_5839648_5	1121440.AUMA01000007_gene1256	9.511e-75	265.0	COG5459@1|root,COG5459@2|Bacteria,1MWMM@1224|Proteobacteria,42WIB@68525|delta/epsilon subdivisions,2WRHR@28221|Deltaproteobacteria,2M7S3@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM Ribosomal small subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
WZS1_k127_5839648_3	338963.Pcar_2704	7.948e-100	342.0	COG1119@1|root,COG1119@2|Bacteria,1MVVM@1224|Proteobacteria,42RN3@68525|delta/epsilon subdivisions,2X6YZ@28221|Deltaproteobacteria,43U13@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.34	ko:K02013,ko:K05776	ko02010,map02010	M00189,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
WZS1_k127_5839648_1	1307761.L21SP2_1005	8.656e-160	531.0	COG4953@1|root,COG4953@2|Bacteria,2J606@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
WZS1_k127_5839648_0	1307761.L21SP2_1004	0.0	1470.0	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
WZS1_k127_5839648_6	468059.AUHA01000004_gene2205	9.453e-56	203.0	COG4221@1|root,COG4221@2|Bacteria,4NHEQ@976|Bacteroidetes,1IXE0@117747|Sphingobacteriia	976|Bacteroidetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
WZS1_k127_5839648_2	1307761.L21SP2_0473	1.001e-142	492.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_5839648_4	452637.Oter_3739	1.978e-88	298.0	COG3148@1|root,COG3148@2|Bacteria,46VF1@74201|Verrucomicrobia,3K7WX@414999|Opitutae	414999|Opitutae	S	DTW	-	-	-	-	-	-	-	-	-	-	-	-	DTW
WZS1_k127_5839648_8	313612.L8106_14895	0.0009869	44.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1G1FK@1117|Cyanobacteria,1H8GM@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,Response_reg
WZS1_k127_5847_1	1499967.BAYZ01000050_gene2838	9.672e-63	221.0	COG0229@1|root,COG0229@2|Bacteria,2NPNC@2323|unclassified Bacteria	2|Bacteria	O	SelR domain	msrB	GO:0003674,GO:0003824,GO:0008113,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016667,GO:0016671,GO:0044419,GO:0051704,GO:0055114	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
WZS1_k127_5847_5	60711.ENSCSAP00000009779	0.0003166	44.0	KOG3895@1|root,KOG3895@2759|Eukaryota,38EM2@33154|Opisthokonta,3BBHP@33208|Metazoa,3CT80@33213|Bilateria,483ZY@7711|Chordata,48X74@7742|Vertebrata,3J6SW@40674|Mammalia,35AIC@314146|Euarchontoglires,4MCGM@9443|Primates,35XUG@314294|Cercopithecoidea	33208|Metazoa	TU	Synapsin N-terminal	SYN1	GO:0000003,GO:0000166,GO:0000228,GO:0000793,GO:0000794,GO:0000795,GO:0001505,GO:0003008,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006810,GO:0006836,GO:0006887,GO:0006950,GO:0007154,GO:0007267,GO:0007268,GO:0007269,GO:0007274,GO:0007275,GO:0007399,GO:0007416,GO:0007528,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007617,GO:0007618,GO:0007619,GO:0007632,GO:0007634,GO:0007635,GO:0008021,GO:0008049,GO:0008144,GO:0008150,GO:0008306,GO:0008355,GO:0009266,GO:0009314,GO:0009408,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010033,GO:0010646,GO:0012505,GO:0012506,GO:0014069,GO:0016020,GO:0016043,GO:0016079,GO:0016192,GO:0017076,GO:0017156,GO:0017157,GO:0017158,GO:0019098,GO:0019899,GO:0019900,GO:0019901,GO:0019953,GO:0022008,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023061,GO:0030133,GO:0030154,GO:0030182,GO:0030424,GO:0030425,GO:0030534,GO:0030554,GO:0030658,GO:0030659,GO:0030672,GO:0031090,GO:0031224,GO:0031225,GO:0031300,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032279,GO:0032386,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032940,GO:0033267,GO:0035639,GO:0036062,GO:0036094,GO:0036477,GO:0040007,GO:0042048,GO:0042221,GO:0042493,GO:0042734,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043195,GO:0043209,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043679,GO:0044085,GO:0044306,GO:0044422,GO:0044424,GO:0044425,GO:0044427,GO:0044428,GO:0044433,GO:0044444,GO:0044446,GO:0044454,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0045055,GO:0045202,GO:0045471,GO:0046677,GO:0046903,GO:0046907,GO:0046928,GO:0046983,GO:0048149,GO:0048167,GO:0048168,GO:0048172,GO:0048306,GO:0048468,GO:0048489,GO:0048589,GO:0048609,GO:0048666,GO:0048699,GO:0048731,GO:0048786,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050804,GO:0050808,GO:0050877,GO:0050890,GO:0050896,GO:0051046,GO:0051049,GO:0051124,GO:0051179,GO:0051234,GO:0051588,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051704,GO:0060179,GO:0060341,GO:0060627,GO:0065007,GO:0065008,GO:0070013,GO:0070382,GO:0071632,GO:0071840,GO:0071944,GO:0072553,GO:0097060,GO:0097091,GO:0097159,GO:0097305,GO:0097367,GO:0097447,GO:0097458,GO:0097479,GO:0097480,GO:0097708,GO:0098563,GO:0098588,GO:0098590,GO:0098693,GO:0098793,GO:0098794,GO:0098805,GO:0098916,GO:0098984,GO:0098993,GO:0099003,GO:0099086,GO:0099172,GO:0099177,GO:0099501,GO:0099503,GO:0099504,GO:0099536,GO:0099537,GO:0099572,GO:0099643,GO:0120025,GO:0120038,GO:0150034,GO:1901265,GO:1901363,GO:1901700,GO:1902803,GO:1903305,GO:1903530,GO:2000300	-	ko:K19941	-	-	-	-	ko00000,ko04131	-	-	-	Synapsin,Synapsin_C,Synapsin_N
WZS1_k127_5847_3	1121272.KB903256_gene5628	8.988e-24	106.0	2CI0U@1|root,32TI1@2|Bacteria,2IKKS@201174|Actinobacteria,4DF69@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5847_4	118161.KB235922_gene3681	7.99e-18	91.0	COG0664@1|root,COG0664@2|Bacteria,1G5M0@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM Cyclic nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
WZS1_k127_5847_2	1297581.H919_03962	4.864e-35	146.0	COG1609@1|root,COG1609@2|Bacteria,1TRHK@1239|Firmicutes,4HB9P@91061|Bacilli,21WHQ@150247|Anoxybacillus	91061|Bacilli	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
WZS1_k127_5847_0	338966.Ppro_0321	4.293e-309	965.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,43SUV@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
WZS1_k127_5867954_2	754027.HMPREF9554_03065	1.648e-11	64.0	COG1253@1|root,COG1253@2|Bacteria,2J61P@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1253 Hemolysins and related protein containing CBS domains	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
WZS1_k127_5867954_1	1410609.JHVB01000001_gene2227	3.78e-64	244.0	COG0457@1|root,COG0457@2|Bacteria,2J5SR@203691|Spirochaetes	203691|Spirochaetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_6,TPR_8
WZS1_k127_5867954_0	744872.Spica_1827	2.058e-169	538.0	COG0057@1|root,COG0057@2|Bacteria,2J5AD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
WZS1_k127_5874534_1	1396418.BATQ01000033_gene5708	1.872e-46	169.0	COG4898@1|root,COG4898@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2200)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WZS1_k127_5874534_0	351160.RCIX1913	5.285e-66	243.0	COG1852@1|root,arCOG02078@2157|Archaea,2XXPW@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF116	-	-	-	-	-	-	-	-	-	-	-	-	DUF116
WZS1_k127_5878894_3	744872.Spica_0965	4.688e-42	169.0	COG2813@1|root,COG2813@2|Bacteria,2J7DS@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	MTS
WZS1_k127_5878894_2	1480694.DC28_10670	1.715e-47	176.0	COG1959@1|root,COG1959@2|Bacteria,2J8PQ@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
WZS1_k127_5878894_1	573413.Spirs_3669	4.001e-64	233.0	COG3264@1|root,COG3264@2|Bacteria	2|Bacteria	M	cellular water homeostasis	kefA	-	-	ko:K05802,ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3	-	-	DEP,MS_channel,cNMP_binding
WZS1_k127_5878894_0	665571.STHERM_c12740	7.329e-114	377.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2J6HE@203691|Spirochaetes	203691|Spirochaetes	F	Orotidine 5''-phosphate decarboxylase	pyrF	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
WZS1_k127_5920346_5	1320556.AVBP01000030_gene164	2.09e-15	78.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,43MCN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
WZS1_k127_5920346_2	1123274.KB899410_gene3550	9.702e-45	165.0	COG2204@1|root,COG2204@2|Bacteria,2JAI3@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WZS1_k127_5920346_0	1123274.KB899410_gene3549	1.385e-69	241.0	COG0745@1|root,COG0745@2|Bacteria,2J7DK@203691|Spirochaetes	203691|Spirochaetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
WZS1_k127_5920346_6	906968.Trebr_0636	1.401e-08	64.0	COG2137@1|root,COG2137@2|Bacteria,2J7QC@203691|Spirochaetes	203691|Spirochaetes	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
WZS1_k127_5920346_3	1124982.MSI_16680	1.658e-41	156.0	COG0103@1|root,COG0103@2|Bacteria,2J8A0@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
WZS1_k127_5920346_1	744872.Spica_0467	3.215e-63	220.0	COG0102@1|root,COG0102@2|Bacteria,2J7C1@203691|Spirochaetes	203691|Spirochaetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
WZS1_k127_5920346_4	545695.TREAZ_2735	4.172e-16	88.0	COG0001@1|root,COG0001@2|Bacteria,2J60V@203691|Spirochaetes	203691|Spirochaetes	H	glutamate-1-semialdehyde 2,1-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_5920606_2	1307761.L21SP2_0473	3.629e-76	286.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_5920606_5	744872.Spica_2155	5.705e-21	98.0	COG0735@1|root,COG0735@2|Bacteria,2J7I1@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
WZS1_k127_5920606_3	1123274.KB899407_gene329	2.695e-47	175.0	COG0716@1|root,COG0716@2|Bacteria,2J6R6@203691|Spirochaetes	203691|Spirochaetes	C	Low-potential electron donor to a number of redox enzymes	-	-	-	ko:K03839	-	-	-	-	ko00000	-	-	-	Flavodoxin_1
WZS1_k127_5920606_7	665571.STHERM_c21310	5.875e-18	91.0	COG0457@1|root,COG0457@2|Bacteria,2J780@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
WZS1_k127_5920606_1	545694.TREPR_0681	3.933e-204	656.0	COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria,2J603@203691|Spirochaetes	203691|Spirochaetes	GPT	PFAM Sodium hydrogen exchanger family	napA-1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
WZS1_k127_5920606_6	1123274.KB899426_gene2790	1.113e-20	101.0	COG3087@1|root,COG3087@2|Bacteria,2J8S5@203691|Spirochaetes	203691|Spirochaetes	D	PFAM Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
WZS1_k127_5920606_4	889378.Spiaf_2715	1.159e-34	140.0	COG0237@1|root,COG0237@2|Bacteria,2J810@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
WZS1_k127_5920606_0	1480694.DC28_12595	3.811e-241	770.0	COG0749@1|root,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WZS1_k127_5947956_4	573413.Spirs_1482	3.427e-76	267.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_5947956_5	537011.PREVCOP_06623	3.329e-47	180.0	COG0566@1|root,COG0566@2|Bacteria,4NG1U@976|Bacteroidetes,2FNE2@200643|Bacteroidia	976|Bacteroidetes	J	RNA methyltransferase TrmH	aviRb	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
WZS1_k127_5947956_2	158190.SpiGrapes_0264	2.675e-139	454.0	2DB7K@1|root,2Z7MK@2|Bacteria,2JAQZ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1576)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1576
WZS1_k127_5947956_9	649639.Bcell_3698	7.321e-16	87.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,4HDDG@91061|Bacilli,1ZBS6@1386|Bacillus	91061|Bacilli	K	transcriptional	yvoA	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
WZS1_k127_5947956_8	1348908.KI518596_gene916	4.912e-37	144.0	COG3624@1|root,COG3624@2|Bacteria,1VI41@1239|Firmicutes,4HH8Q@91061|Bacilli,1ZG1W@1386|Bacillus	91061|Bacilli	P	Phosphonate metabolism protein PhnG	phnG	-	2.7.8.37	ko:K06166	ko00440,map00440	-	R10185	RC00005,RC00063	ko00000,ko00001,ko01000	-	-	-	PhnG
WZS1_k127_5947956_6	1449063.JMLS01000003_gene2037	1.337e-42	163.0	COG3625@1|root,COG3625@2|Bacteria,1VHCA@1239|Firmicutes,4HHKS@91061|Bacilli,2708X@186822|Paenibacillaceae	91061|Bacilli	P	Bacterial phosphonate metabolism protein (PhnH)	phnH	-	2.7.8.37	ko:K06165	ko00440,map00440	-	R10185	RC00005,RC00063	ko00000,ko00001,ko01000	-	-	-	PhnH
WZS1_k127_5947956_0	1118054.CAGW01000062_gene2311	6.629e-156	501.0	COG3626@1|root,COG3626@2|Bacteria,1TRIJ@1239|Firmicutes,4HCGZ@91061|Bacilli,26V3M@186822|Paenibacillaceae	91061|Bacilli	P	Bacterial phosphonate metabolism protein (PhnI)	phnI	-	2.7.8.37	ko:K06164	ko00440,map00440	-	R10185	RC00005,RC00063	ko00000,ko00001,ko01000	-	-	-	PhnI
WZS1_k127_5947956_1	1033734.CAET01000038_gene150	7.178e-141	452.0	COG3627@1|root,COG3627@2|Bacteria,1TS87@1239|Firmicutes,4HD7E@91061|Bacilli,1ZE19@1386|Bacillus	91061|Bacilli	P	Phosphonate metabolism protein PhnJ	phnJ	-	4.7.1.1	ko:K06163	ko00440,map00440	-	R10204	RC03078,RC03079	ko00000,ko00001,ko01000	-	-	-	PhnJ
WZS1_k127_5947956_3	1121289.JHVL01000049_gene856	1.226e-104	347.0	COG4107@1|root,COG4107@2|Bacteria,1TPHX@1239|Firmicutes,2494Q@186801|Clostridia,36HKV@31979|Clostridiaceae	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K05781	-	-	-	-	ko00000	-	-	-	ABC_tran
WZS1_k127_5984172_1	1318628.MARLIPOL_08849	1.044e-65	234.0	COG0642@1|root,COG0784@1|root,COG3726@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3726@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,463ZD@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0642 Signal transduction histidine kinase	sagS	-	2.7.13.3	ko:K20973	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
WZS1_k127_5984172_0	1121403.AUCV01000012_gene4100	4.698e-119	392.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,1RDA1@1224|Proteobacteria,43BUM@68525|delta/epsilon subdivisions,2WMFR@28221|Deltaproteobacteria,2MIPP@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C,Pro_isomerase
WZS1_k127_5984172_3	1408321.JNJD01000006_gene1234	1.494e-17	93.0	COG2169@1|root,COG2169@2|Bacteria,1UPIT@1239|Firmicutes,25HHD@186801|Clostridia,27UM3@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18
WZS1_k127_5984172_4	1307761.L21SP2_2748	4.062e-16	80.0	COG1886@1|root,COG1886@2|Bacteria	2|Bacteria	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	-	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
WZS1_k127_5984172_2	1307761.L21SP2_1191	3.33e-37	156.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
WZS1_k127_5993974_2	1123274.KB899415_gene2476	7.997e-36	139.0	COG0164@1|root,COG0164@2|Bacteria,2J7CW@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
WZS1_k127_5993974_0	573413.Spirs_1868	9.74e-287	908.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
WZS1_k127_5993974_1	754027.HMPREF9554_00668	5.739e-72	246.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
WZS1_k127_5999854_0	243275.TDE_1558	1.591e-58	219.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
WZS1_k127_6003358_4	744872.Spica_0190	1.991e-10	64.0	COG1538@1|root,COG1538@2|Bacteria,2J5YA@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
WZS1_k127_6003358_3	1121912.AUHD01000002_gene3289	3.552e-18	96.0	COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1HXW9@117743|Flavobacteriia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
WZS1_k127_6003358_1	526222.Desal_0948	9.524e-223	726.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
WZS1_k127_6003358_2	1480694.DC28_08735	5.969e-147	475.0	COG0025@1|root,COG0025@2|Bacteria,2J74Z@203691|Spirochaetes	203691|Spirochaetes	P	PFAM sodium hydrogen exchanger	cdu2	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
WZS1_k127_6003358_0	1122919.KB905627_gene77	0.0	1102.0	COG0178@1|root,COG0178@2|Bacteria,1TR1H@1239|Firmicutes,4H9RE@91061|Bacilli,26QI4@186822|Paenibacillaceae	91061|Bacilli	L	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
WZS1_k127_6040335_0	889378.Spiaf_2347	8.66e-125	407.0	COG0366@1|root,COG4945@1|root,COG0366@2|Bacteria,COG4945@2|Bacteria	2|Bacteria	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	3.2.1.1,3.2.1.3	ko:K01176,ko:K01178	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R01790,R01791,R02108,R02112,R06199,R11262	-	ko00000,ko00001,ko01000	-	GH13,GH15	-	Alpha-amylase,Cu_amine_oxidN1,Glucodextran_B,Glucodextran_C,Glucodextran_N,Glyco_hydro_15,Glyco_hydro_49,Glyco_hydro_49N
WZS1_k127_6055425_0	1304865.JAGF01000001_gene3427	4.327e-34	151.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
WZS1_k127_6076450_0	1480694.DC28_04625	2.457e-58	228.0	COG2373@1|root,COG3420@1|root,COG2373@2|Bacteria,COG3420@2|Bacteria,2J58E@203691|Spirochaetes	203691|Spirochaetes	P	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
WZS1_k127_6085142_1	395493.BegalDRAFT_3508	2.97e-61	230.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,Peptidase_C13,Peptidase_C14
WZS1_k127_6085142_0	59374.Fisuc_2581	2.008e-318	994.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
WZS1_k127_6108105_0	218851.Aquca_016_00172.1	1.056e-34	133.0	2CPQ8@1|root,2R2CM@2759|Eukaryota,37X79@33090|Viridiplantae	33090|Viridiplantae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6111260_2	665571.STHERM_c11640	7.019e-59	216.0	2F8HF@1|root,340W9@2|Bacteria,2J5EY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6111260_3	243275.TDE_1088	3.707e-32	134.0	COG2199@1|root,COG3706@2|Bacteria,2J8YI@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6111260_0	1313292.BCO_0052700	2.426e-112	388.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,2J72G@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	lysM	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Amidase_3,LysM,Peptidase_M23
WZS1_k127_6111260_1	1408473.JHXO01000009_gene3459	3.088e-78	273.0	COG1968@1|root,COG1968@2|Bacteria,4NGIZ@976|Bacteroidetes,2FMST@200643|Bacteroidia	976|Bacteroidetes	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
WZS1_k127_6114407_1	926692.AZYG01000040_gene1527	2.097e-27	120.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes	1239|Firmicutes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
WZS1_k127_6114407_0	1410626.JHXB01000019_gene1565	8.66e-38	146.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
WZS1_k127_6114407_2	1304885.AUEY01000111_gene2949	6.751e-09	61.0	COG4118@1|root,COG4118@2|Bacteria,1NP8X@1224|Proteobacteria,42XXG@68525|delta/epsilon subdivisions,2WWJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
WZS1_k127_6135913_0	1480694.DC28_05080	5.603e-131	434.0	COG1109@1|root,COG1109@2|Bacteria,2J6Q6@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	femD	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_III
WZS1_k127_6135913_2	744872.Spica_0860	2.065e-34	145.0	2DBQ8@1|root,2ZACX@2|Bacteria,2J648@203691|Spirochaetes	203691|Spirochaetes	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
WZS1_k127_6135913_1	1123274.KB899429_gene2874	8.591e-52	204.0	COG1536@1|root,COG1536@2|Bacteria,2J6EK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar motor switch protein	fliG-1	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
WZS1_k127_6139629_0	1307761.L21SP2_3229	6.823e-83	287.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
WZS1_k127_6139629_1	1202962.KB907161_gene372	1.702e-77	273.0	COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA	rlmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052916,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.172,2.1.1.174	ko:K00564,ko:K11391	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
WZS1_k127_6139629_2	1307761.L21SP2_2438	6.109e-29	124.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,SpoIIE,dCache_1
WZS1_k127_6139629_3	744872.Spica_1482	1.126e-21	103.0	290DX@1|root,32INT@2|Bacteria,2J83J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6160958_7	1307761.L21SP2_1855	4.891e-27	118.0	2FKFF@1|root,34C2R@2|Bacteria,2J7SF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6160958_1	1307761.L21SP2_1854	6.656e-109	362.0	COG0190@1|root,COG0190@2|Bacteria,2J5PR@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
WZS1_k127_6160958_4	1480694.DC28_10570	1.042e-44	181.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
WZS1_k127_6160958_2	439235.Dalk_5096	4.046e-76	262.0	COG0138@1|root,COG0138@2|Bacteria,1N2UC@1224|Proteobacteria,42NFS@68525|delta/epsilon subdivisions,2X5JJ@28221|Deltaproteobacteria,2MIV7@213118|Desulfobacterales	28221|Deltaproteobacteria	F	MGS-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AICARFT_IMPCHas,MGS
WZS1_k127_6160958_0	439235.Dalk_3269	2.493e-187	593.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
WZS1_k127_6160958_9	545694.TREPR_1731	7.033e-11	68.0	28RYI@1|root,2ZEAI@2|Bacteria,2J97I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	-
WZS1_k127_6160958_5	573413.Spirs_2423	1.03e-38	162.0	2F8XC@1|root,34196@2|Bacteria,2J6EN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6160958_3	573413.Spirs_2422	5.577e-74	260.0	COG0618@1|root,COG0618@2|Bacteria,2J74X@203691|Spirochaetes	203691|Spirochaetes	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
WZS1_k127_6160958_6	1123274.KB899419_gene1994	2.93e-38	157.0	COG2304@1|root,COG2304@2|Bacteria,2J712@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
WZS1_k127_6163461_1	102232.GLO73106DRAFT_00009550	2.885e-39	160.0	COG1523@1|root,COG1523@2|Bacteria,1G219@1117|Cyanobacteria	1117|Cyanobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
WZS1_k127_6163461_3	1280390.CBQR020000144_gene3605	4.05e-12	78.0	COG3693@1|root,COG5297@1|root,COG3693@2|Bacteria,COG5297@2|Bacteria,1TT5V@1239|Firmicutes,4HT5P@91061|Bacilli,26SKZ@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_10
WZS1_k127_6163461_2	502025.Hoch_5261	1.169e-16	92.0	COG2819@1|root,COG2819@2|Bacteria,1RAB4@1224|Proteobacteria,43F1Q@68525|delta/epsilon subdivisions,2X30X@28221|Deltaproteobacteria,2YTX8@29|Myxococcales	28221|Deltaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
WZS1_k127_6163461_0	449447.MAE_19430	3.903e-235	745.0	COG1523@1|root,COG1523@2|Bacteria,1G219@1117|Cyanobacteria	1117|Cyanobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
WZS1_k127_6177553_0	906968.Trebr_1063	2.547e-192	614.0	COG2274@1|root,COG2274@2|Bacteria,2J641@203691|Spirochaetes	203691|Spirochaetes	V	Bacteriocin ABC transporter, ATP-binding permease	-	-	-	ko:K06147,ko:K20344	ko02010,ko02024,map02010,map02024	-	-	-	ko00000,ko00001,ko02000	3.A.1.106,3.A.1.109,3.A.1.112,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
WZS1_k127_6177553_1	889378.Spiaf_0762	1.444e-06	58.0	COG0297@1|root,COG0297@2|Bacteria,2J9RH@203691|Spirochaetes	203691|Spirochaetes	G	glycogen (starch) synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_5
WZS1_k127_6180493_0	394503.Ccel_0858	7.249e-177	591.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_62306_0	1408473.JHXO01000001_gene2161	0.0	1353.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,2FMI7@200643|Bacteroidia	976|Bacteroidetes	E	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
WZS1_k127_6255528_6	744872.Spica_1991	6.632e-17	84.0	COG3858@1|root,COG3858@2|Bacteria,2J6UU@203691|Spirochaetes	203691|Spirochaetes	S	hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
WZS1_k127_6255528_3	243275.TDE_1226	4.249e-94	318.0	COG0803@1|root,COG0803@2|Bacteria,2J5T0@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the bacterial solute-binding protein 9 family	troA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K11707	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ZnuA
WZS1_k127_6255528_2	221027.JO40_13255	5.211e-106	349.0	COG1121@1|root,COG1121@2|Bacteria,2J6HR@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	znuC	-	-	ko:K09817,ko:K11607,ko:K11710	ko02010,map02010	M00242,M00317,M00319	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5,3.A.1.15.7,3.A.1.15.9	-	-	ABC_tran
WZS1_k127_6255528_0	1123274.KB899407_gene299	1.067e-112	375.0	COG1108@1|root,COG1108@2|Bacteria,2J5FA@203691|Spirochaetes	203691|Spirochaetes	U	ABC 3 transport family	troC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K11708	ko02010,map02010	M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC-3
WZS1_k127_6255528_1	1123274.KB899407_gene300	1.848e-107	359.0	COG1108@1|root,COG1108@2|Bacteria,2J798@203691|Spirochaetes	203691|Spirochaetes	P	ABC 3 transport family	troD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09819,ko:K11605,ko:K11709	ko02010,map02010	M00243,M00317,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.7,3.A.1.15.9	-	-	ABC-3
WZS1_k127_6255528_4	221027.JO40_13270	2.934e-48	187.0	COG1321@1|root,COG1321@2|Bacteria,2J7MB@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
WZS1_k127_6255528_5	368408.Tpen_0087	5.699e-24	115.0	COG1215@1|root,arCOG01389@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
WZS1_k127_6265371_2	889378.Spiaf_2590	2.408e-31	135.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
WZS1_k127_6265371_0	324602.Caur_3724	4.437e-141	461.0	COG2239@1|root,COG2239@2|Bacteria,2G6H7@200795|Chloroflexi,376RI@32061|Chloroflexia	32061|Chloroflexia	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
WZS1_k127_6265371_3	1410609.JHVB01000013_gene62	2.684e-30	129.0	COG1652@1|root,COG1652@2|Bacteria,2J7QX@203691|Spirochaetes	203691|Spirochaetes	S	Treponemal membrane protein	tmpB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LysM
WZS1_k127_6265371_1	768671.ThimaDRAFT_0319	3.82e-32	133.0	COG0702@1|root,COG0702@2|Bacteria,1RDKF@1224|Proteobacteria,1S0A1@1236|Gammaproteobacteria,1WWZA@135613|Chromatiales	135613|Chromatiales	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
WZS1_k127_6268563_0	665571.STHERM_c01720	6.093e-49	202.0	COG2931@1|root,COG2931@2|Bacteria,2JA4N@203691|Spirochaetes	203691|Spirochaetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
WZS1_k127_6268563_1	665571.STHERM_c01720	2.801e-19	98.0	COG2931@1|root,COG2931@2|Bacteria,2JA4N@203691|Spirochaetes	203691|Spirochaetes	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
WZS1_k127_6270993_1	1120999.JONM01000006_gene2485	1.696e-71	250.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2VI04@28216|Betaproteobacteria,2KQ08@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
WZS1_k127_6270993_0	93220.LV28_06595	5.168e-115	377.0	COG0583@1|root,COG0583@2|Bacteria,1MUIX@1224|Proteobacteria,2VI6K@28216|Betaproteobacteria,1K274@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	metR	-	-	ko:K03576	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
WZS1_k127_6270993_2	889378.Spiaf_2310	3.426e-06	52.0	298IC@1|root,2ZVPA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6277883_3	794903.OPIT5_05790	3.117e-12	76.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
WZS1_k127_6277883_2	1122176.KB903554_gene3842	4.542e-25	121.0	COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,4NM1E@976|Bacteroidetes,1IWA5@117747|Sphingobacteriia	976|Bacteroidetes	MP	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
WZS1_k127_6277883_1	665571.STHERM_c07970	1.043e-63	229.0	COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN_1	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	CBS,HTH_17,PTS_EIIA_2
WZS1_k127_6277883_0	1480694.DC28_15420	1.515e-119	393.0	COG1055@1|root,COG1055@2|Bacteria,2J6QU@203691|Spirochaetes	203691|Spirochaetes	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp
WZS1_k127_6291455_10	596324.TREVI0001_1617	0.0001763	54.0	2EYV8@1|root,33S2C@2|Bacteria,2J65B@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565
WZS1_k127_6291455_4	1385935.N836_00875	9.62e-31	132.0	COG0561@1|root,COG0561@2|Bacteria,1GDI4@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
WZS1_k127_6291455_3	1307761.L21SP2_2258	9.324e-38	146.0	COG1959@1|root,COG1959@2|Bacteria,2J89V@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, BadM Rrf2 family	-	-	-	ko:K17472	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
WZS1_k127_6291455_7	485917.Phep_0460	5.611e-16	86.0	COG0818@1|root,COG0818@2|Bacteria,4NQ39@976|Bacteroidetes,1ITPQ@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM Prokaryotic diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
WZS1_k127_6291455_9	1123230.ARQJ01000033_gene1685	2.278e-06	57.0	COG2340@1|root,COG2340@2|Bacteria,1TSUX@1239|Firmicutes,4HDMJ@91061|Bacilli,4GXIP@90964|Staphylococcaceae	91061|Bacilli	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CAP_assoc_N,SLH
WZS1_k127_6291455_6	1120998.AUFC01000002_gene2676	1.24e-27	123.0	COG1051@1|root,COG1051@2|Bacteria,1UIGB@1239|Firmicutes,24NCA@186801|Clostridia	186801|Clostridia	F	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WZS1_k127_6291455_5	714961.BFZC1_02282	1.444e-28	126.0	COG0457@1|root,COG0457@2|Bacteria,1V3U6@1239|Firmicutes,4HFWW@91061|Bacilli,3IY4S@400634|Lysinibacillus	91061|Bacilli	S	Tetratrico peptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_5,TPR_6,TPR_8
WZS1_k127_6291455_0	1480694.DC28_01020	8.117e-303	938.0	COG1217@1|root,COG1217@2|Bacteria,2J9HZ@203691|Spirochaetes	203691|Spirochaetes	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
WZS1_k127_6291455_1	1137799.GZ78_06520	1.122e-44	168.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1XJUJ@135619|Oceanospirillales	135619|Oceanospirillales	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
WZS1_k127_6291455_8	1250232.JQNJ01000001_gene3538	3.843e-13	82.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
WZS1_k127_6291455_2	449447.MAE_19430	6.324e-42	160.0	COG1523@1|root,COG1523@2|Bacteria,1G219@1117|Cyanobacteria	1117|Cyanobacteria	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
WZS1_k127_6332359_0	1480694.DC28_02535	4.962e-78	269.0	COG0448@1|root,COG0448@2|Bacteria,2J5UB@203691|Spirochaetes	203691|Spirochaetes	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
WZS1_k127_6332359_1	573413.Spirs_2620	1.407e-27	117.0	COG1051@1|root,COG1051@2|Bacteria,2J8CP@203691|Spirochaetes	203691|Spirochaetes	F	PFAM NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4
WZS1_k127_6332359_2	744872.Spica_1439	5.147e-20	95.0	2FC9X@1|root,2ZJPR@2|Bacteria,2J8DF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6332492_0	545694.TREPR_0608	3.741e-168	539.0	COG0205@1|root,COG0205@2|Bacteria,2J6KH@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
WZS1_k127_6332492_1	1321815.HMPREF9193_00583	1.429e-133	432.0	COG1087@1|root,COG1087@2|Bacteria,2J5YD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
WZS1_k127_6332492_3	744872.Spica_2837	5.459e-64	229.0	COG1121@1|root,COG1121@2|Bacteria	2|Bacteria	P	zinc-transporting ATPase activity	znuC	-	3.6.3.34	ko:K02013,ko:K09817,ko:K09820	ko02010,map02010	M00240,M00242,M00243	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
WZS1_k127_6332492_4	744872.Spica_1295	1.093e-34	153.0	2FFB7@1|root,3478X@2|Bacteria,2J8CB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6332492_6	545694.TREPR_2495	9.682e-22	111.0	COG2604@1|root,COG2604@2|Bacteria,2J5AX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
WZS1_k127_6332492_5	1123274.KB899415_gene2540	1.128e-23	115.0	COG2199@1|root,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	-	-	2.7.7.65	ko:K02065,ko:K21023	ko02010,ko02025,map02010,map02025	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.27	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,HlyD_D23,PAS_9,Response_reg
WZS1_k127_6332492_2	744872.Spica_1288	9.284e-80	285.0	COG3225@1|root,COG3225@2|Bacteria,2J6NB@203691|Spirochaetes	203691|Spirochaetes	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
WZS1_k127_6337346_12	1123242.JH636434_gene5244	8.969e-05	51.0	2E55N@1|root,32ZYI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6337346_5	744872.Spica_1200	4.326e-68	241.0	COG0294@1|root,COG0294@2|Bacteria,2J6FQ@203691|Spirochaetes	203691|Spirochaetes	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
WZS1_k127_6337346_1	1307761.L21SP2_2416	7.373e-88	298.0	COG1624@1|root,COG1624@2|Bacteria,2J5ZB@203691|Spirochaetes	203691|Spirochaetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
WZS1_k127_6337346_7	1123274.KB899413_gene770	1.019e-62	228.0	COG4856@1|root,COG4856@2|Bacteria,2J5XW@203691|Spirochaetes	203691|Spirochaetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
WZS1_k127_6337346_9	545694.TREPR_1938	5.78e-31	125.0	COG0736@1|root,COG0736@2|Bacteria,2J8AA@203691|Spirochaetes	203691|Spirochaetes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
WZS1_k127_6337346_2	1123274.KB899413_gene768	3.201e-86	293.0	COG1655@1|root,COG1655@2|Bacteria,2J5GN@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225
WZS1_k127_6337346_6	545695.TREAZ_0151	2.981e-66	235.0	COG0101@1|root,COG0101@2|Bacteria,2J65Z@203691|Spirochaetes	203691|Spirochaetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
WZS1_k127_6337346_11	665571.STHERM_c18320	1.168e-14	82.0	COG1573@1|root,COG1573@2|Bacteria,2J612@203691|Spirochaetes	203691|Spirochaetes	L	Uracil-DNA glycosylase, family 4	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
WZS1_k127_6337346_0	889378.Spiaf_1079	9.523e-206	658.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
WZS1_k127_6337346_8	744872.Spica_2334	7.707e-57	202.0	COG0242@1|root,COG0242@2|Bacteria,2J7X0@203691|Spirochaetes	203691|Spirochaetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
WZS1_k127_6337346_3	889378.Spiaf_1091	6.416e-85	291.0	COG0223@1|root,COG0223@2|Bacteria,2J621@203691|Spirochaetes	203691|Spirochaetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
WZS1_k127_6337346_4	744872.Spica_2332	3.98e-72	256.0	COG2815@1|root,COG2815@2|Bacteria,2J5J2@203691|Spirochaetes	203691|Spirochaetes	S	Pasta domain protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
WZS1_k127_6337346_10	665571.STHERM_c19990	5.833e-31	127.0	COG0340@1|root,COG0340@2|Bacteria,2J617@203691|Spirochaetes	203691|Spirochaetes	H	biotin acetyl-CoA-carboxylase ligase	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
WZS1_k127_6346846_8	1417296.U879_15835	0.0001259	47.0	COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,Response_reg,SpoIIE
WZS1_k127_6346846_1	1480694.DC28_05445	9.528e-144	484.0	COG1413@1|root,COG2211@1|root,COG1413@2|Bacteria,COG2211@2|Bacteria,2J5U6@203691|Spirochaetes	203691|Spirochaetes	CG	transporter, major facilitator family	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,MFS_1
WZS1_k127_6346846_6	936154.STP_1186	3.197e-51	200.0	COG0641@1|root,COG0641@2|Bacteria,1UZWZ@1239|Firmicutes,4HFIV@91061|Bacilli	91061|Bacilli	C	4Fe-4S single cluster domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
WZS1_k127_6346846_7	243265.plu2216	5.883e-48	189.0	COG0488@1|root,COG1132@1|root,COG0488@2|Bacteria,COG1132@2|Bacteria,1RC33@1224|Proteobacteria,1S2CB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6346846_0	889378.Spiaf_0524	1.481e-261	817.0	COG0059@1|root,COG0059@2|Bacteria,2J60P@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
WZS1_k127_6346846_3	744872.Spica_2143	8.168e-116	387.0	COG0687@1|root,COG0687@2|Bacteria,2J5D5@203691|Spirochaetes	203691|Spirochaetes	P	Spermidine putrescine-binding periplasmic protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
WZS1_k127_6346846_5	744872.Spica_2142	6.523e-91	312.0	COG1177@1|root,COG1177@2|Bacteria,2J5IB@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type spermidine putrescine transport system, permease component II	potC	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
WZS1_k127_6346846_4	744872.Spica_2141	3.681e-101	336.0	COG1176@1|root,COG1176@2|Bacteria,2J7YM@203691|Spirochaetes	203691|Spirochaetes	P	Putrescine transport system permease	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
WZS1_k127_6346846_2	744872.Spica_2140	1.07e-143	463.0	COG3842@1|root,COG3842@2|Bacteria,2J6IQ@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
WZS1_k127_6356956_2	4098.XP_009609630.1	6.612e-05	46.0	COG2801@1|root,KOG0017@2759|Eukaryota	4098.XP_009609630.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6356956_1	3750.XP_008378407.1	4.1e-09	61.0	COG2801@1|root,KOG0017@2759|Eukaryota,37R6P@33090|Viridiplantae,3G8BW@35493|Streptophyta,4JN0G@91835|fabids	35493|Streptophyta	L	Uncharacterized protein K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,Retrotrans_gag,rve
WZS1_k127_6356956_0	4098.XP_009612395.1	2.439e-09	60.0	COG2801@1|root,KOG0017@2759|Eukaryota	4098.XP_009612395.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6371676_0	889378.Spiaf_0914	2.561e-182	580.0	28HY3@1|root,2Z83I@2|Bacteria	2|Bacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
WZS1_k127_6371676_2	102232.GLO73106DRAFT_00015440	7.583e-38	152.0	COG1434@1|root,COG1434@2|Bacteria,1G1QC@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
WZS1_k127_6371676_1	744872.Spica_1616	2.316e-103	351.0	COG0457@1|root,COG2357@1|root,COG0457@2|Bacteria,COG2357@2|Bacteria,2J6E1@203691|Spirochaetes	203691|Spirochaetes	S	RelA SpoT domain protein	-	-	2.7.6.5	ko:K07816	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	RelA_SpoT,TPR_1,TPR_16,TPR_2,TPR_8
WZS1_k127_6371676_3	1121921.KB898709_gene308	9.725e-22	99.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	glucose sorbosone	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	iSbBS512_1146.SbBS512_E2507	GSDH
WZS1_k127_638338_4	1120917.AQXM01000063_gene2068	3.117e-11	66.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,1W7NA@1268|Micrococcaceae	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
WZS1_k127_638338_0	1123274.KB899421_gene1763	3.042e-301	937.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
WZS1_k127_638338_1	314723.BH0804	3.923e-30	121.0	COG0184@1|root,COG0184@2|Bacteria,2J91K@203691|Spirochaetes	203691|Spirochaetes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
WZS1_k127_638338_2	573413.Spirs_2031	1.358e-24	113.0	COG0196@1|root,COG0196@2|Bacteria,2J7F1@203691|Spirochaetes	203691|Spirochaetes	H	riboflavin biosynthesis protein	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
WZS1_k127_638338_3	32049.SYNPCC7002_A0485	1.848e-14	79.0	COG0130@1|root,COG0130@2|Bacteria,1G0S5@1117|Cyanobacteria,1GYC1@1129|Synechococcus	1117|Cyanobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
WZS1_k127_6392744_5	1173024.KI912152_gene817	1.536e-22	102.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
WZS1_k127_6392744_2	1189612.A33Q_1637	1.01e-41	158.0	COG2764@1|root,COG3832@1|root,COG2764@2|Bacteria,COG3832@2|Bacteria,4NFVK@976|Bacteroidetes,47MD3@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt,AHSA1
WZS1_k127_6392744_1	1307761.L21SP2_0717	1.279e-79	271.0	COG2013@1|root,COG2013@2|Bacteria,2J7X8@203691|Spirochaetes	203691|Spirochaetes	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
WZS1_k127_6392744_0	595494.Tola_1479	4.527e-98	325.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
WZS1_k127_6392744_3	485913.Krac_3628	2.243e-29	121.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WZS1_k127_6392744_4	1499684.CCNP01000021_gene2643	2.746e-25	123.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1VQTU@1239|Firmicutes,24D8M@186801|Clostridia,36GZE@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_639561_0	573413.Spirs_1817	9.315e-247	777.0	COG0465@1|root,COG0465@2|Bacteria,2J58Y@203691|Spirochaetes	203691|Spirochaetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
WZS1_k127_639561_1	1307761.L21SP2_1453	1.446e-73	267.0	COG0265@1|root,COG0265@2|Bacteria,2J5SD@203691|Spirochaetes	203691|Spirochaetes	O	Trypsin domain PDZ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
WZS1_k127_6405988_5	573413.Spirs_4078	2.084e-93	312.0	COG1639@1|root,COG1639@2|Bacteria,2J74B@203691|Spirochaetes	203691|Spirochaetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
WZS1_k127_6405988_2	573413.Spirs_4079	2.381e-123	402.0	COG1235@1|root,COG1235@2|Bacteria,2J6YX@203691|Spirochaetes	203691|Spirochaetes	S	Beta-lactamase superfamily domain	elaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
WZS1_k127_6405988_6	744872.Spica_2830	1.8e-72	274.0	2EWA9@1|root,33PP0@2|Bacteria,2J5HS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6405988_4	889378.Spiaf_2813	1.648e-108	355.0	COG1351@1|root,COG1351@2|Bacteria,2J68R@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
WZS1_k127_6405988_8	1121440.AUMA01000005_gene2531	1.421e-09	69.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1R7R8@1224|Proteobacteria,42NER@68525|delta/epsilon subdivisions,2WUV0@28221|Deltaproteobacteria,2M8RU@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS,PAS_3,PAS_4,SBP_bac_3
WZS1_k127_6405988_7	1307759.JOMJ01000003_gene1541	1.119e-24	116.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	fleS	-	2.7.13.3	ko:K10942	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Pkinase,Response_reg
WZS1_k127_6405988_9	243090.RB11857	1.432e-09	63.0	COG3162@1|root,COG3162@2|Bacteria,2J1BX@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
WZS1_k127_6405988_0	1121396.KB893012_gene4098	2.6e-234	741.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2WK5T@28221|Deltaproteobacteria,2MPVV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sodium:solute symporter family	aplA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
WZS1_k127_6405988_3	665571.STHERM_c21360	8.274e-109	371.0	COG5001@1|root,COG5001@2|Bacteria,2J5Z5@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
WZS1_k127_6405988_1	498211.CJA_2160	3.116e-225	713.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1FG7D@10|Cellvibrio	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
WZS1_k127_6406403_2	1123274.KB899410_gene3389	1.42e-65	240.0	2F1P1@1|root,33UPB@2|Bacteria,2J896@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6406403_1	1480694.DC28_05245	3.25e-103	341.0	COG0708@1|root,COG0708@2|Bacteria,2J62E@203691|Spirochaetes	203691|Spirochaetes	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
WZS1_k127_6406403_6	1305737.JAFX01000001_gene2427	1.746e-30	136.0	COG0457@1|root,COG3920@1|root,COG0457@2|Bacteria,COG3920@2|Bacteria,4NINT@976|Bacteroidetes	976|Bacteroidetes	T	Pfam Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,TPR_12,TPR_8
WZS1_k127_6406403_5	882.DVU_0722	3.605e-36	154.0	COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,1NC9X@1224|Proteobacteria,43BK0@68525|delta/epsilon subdivisions,2X91F@28221|Deltaproteobacteria,2MH86@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,HD,Response_reg
WZS1_k127_6406403_0	1123274.KB899412_gene1498	5.58e-118	396.0	COG0771@1|root,COG0771@2|Bacteria,2J5IW@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
WZS1_k127_6406403_3	744872.Spica_0979	3.593e-63	228.0	2EYH2@1|root,33RQY@2|Bacteria,2J9M4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6406403_7	744872.Spica_1194	2.316e-05	57.0	2FJ33@1|root,34ATE@2|Bacteria,2J862@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6406403_4	573413.Spirs_2274	2.788e-62	228.0	COG1293@1|root,COG1293@2|Bacteria,2J61Z@203691|Spirochaetes	203691|Spirochaetes	K	Fibrinogen-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
WZS1_k127_6413745_4	1266845.Q783_09290	1.051e-30	126.0	COG1051@1|root,COG1051@2|Bacteria,1VAMK@1239|Firmicutes,4HKCB@91061|Bacilli	91061|Bacilli	F	Belongs to the Nudix hydrolase family	apfA	-	3.6.1.61	ko:K18445	ko00230,map00230	-	R00184	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
WZS1_k127_6413745_5	1499967.BAYZ01000078_gene999	1.24e-28	119.0	COG3123@1|root,COG3123@2|Bacteria,2NRH4@2323|unclassified Bacteria	2|Bacteria	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
WZS1_k127_6413745_0	314723.BH0446	3.809e-201	644.0	COG0173@1|root,COG0173@2|Bacteria,2J5KG@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
WZS1_k127_6413745_6	545695.TREAZ_3533	9.469e-06	56.0	2ANZ6@1|root,31E07@2|Bacteria,2JB87@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6413745_3	1278307.KB907015_gene3540	1.516e-67	247.0	COG2114@1|root,COG2114@2|Bacteria,1P8ZU@1224|Proteobacteria,1S6BW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19
WZS1_k127_6413745_2	118173.KB235910_gene4901	3.691e-98	340.0	COG0827@1|root,COG0827@2|Bacteria	2|Bacteria	L	DNA restriction-modification system	-	-	-	-	-	-	-	-	-	-	-	-	DUF4942,N6_Mtase
WZS1_k127_6413745_1	857087.Metme_4298	1.096e-108	360.0	2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,1RNI9@1236|Gammaproteobacteria,1XEQJ@135618|Methylococcales	135618|Methylococcales	S	PFAM 5'-nucleotidase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5-nucleotidase
WZS1_k127_64174_2	1460634.JCM19037_1532	9.072e-64	227.0	COG4606@1|root,COG4606@2|Bacteria,1TSQX@1239|Firmicutes,4H9P2@91061|Bacilli	91061|Bacilli	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	yclN	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
WZS1_k127_64174_3	1408422.JHYF01000014_gene252	6.173e-61	222.0	COG4605@1|root,COG4605@2|Bacteria,1TP3V@1239|Firmicutes,24ATQ@186801|Clostridia,36FVU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
WZS1_k127_64174_1	1243664.CAVL020000056_gene2356	1.04e-66	242.0	COG4604@1|root,COG4604@2|Bacteria,1UHP5@1239|Firmicutes,4HBJE@91061|Bacilli,1ZB9F@1386|Bacillus	91061|Bacilli	P	ABC transporter, ATP-binding protein	yclP	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
WZS1_k127_64174_6	1307761.L21SP2_2731	2.684e-25	120.0	COG0369@1|root,COG0369@2|Bacteria	2|Bacteria	C	hydroxylamine reductase activity	mioC	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0055114	1.8.1.2	ko:K00380,ko:K06205	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_1,p450
WZS1_k127_64174_5	1196323.ALKF01000203_gene3763	1.078e-31	135.0	COG4977@1|root,COG4977@2|Bacteria,1UQWM@1239|Firmicutes,4HF5C@91061|Bacilli,26T6R@186822|Paenibacillaceae	91061|Bacilli	K	AraC family transcriptional regulator	pchR	-	-	-	-	-	-	-	-	-	-	-	HTH_18
WZS1_k127_64174_0	338969.Rfer_0150	6.234e-154	495.0	COG4335@1|root,COG4335@2|Bacteria,1P0C1@1224|Proteobacteria,2VISN@28216|Betaproteobacteria,4ADJS@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation,HEAT
WZS1_k127_64174_4	1321778.HMPREF1982_03077	1.177e-34	150.0	COG5297@1|root,COG5297@2|Bacteria,1TS2G@1239|Firmicutes,24AN1@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolase family 66	-	-	3.2.1.11	ko:K05988	ko00500,map00500	-	R11309	-	ko00000,ko00001,ko01000	-	GH66	-	Glyco_hydro_66
WZS1_k127_6441400_0	399741.Spro_1540	4.262e-75	266.0	COG3903@1|root,COG3903@2|Bacteria,1QU1V@1224|Proteobacteria,1RZRS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	NB-ARC domain	-	-	-	ko:K16247	-	-	-	-	ko00000,ko03000	-	-	-	NB-ARC
WZS1_k127_6441400_1	1141663.OOC_00395	1.283e-06	56.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_37
WZS1_k127_6454705_0	59374.Fisuc_0654	2.536e-163	525.0	COG0372@1|root,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
WZS1_k127_6454705_1	926569.ANT_30100	2.399e-21	109.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Lactamase_B,Lactamase_B_2,cNMP_binding
WZS1_k127_6454705_2	1144275.COCOR_00365	0.0003002	53.0	COG0664@1|root,COG0664@2|Bacteria,1QX62@1224|Proteobacteria,42S57@68525|delta/epsilon subdivisions,2WNY0@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
WZS1_k127_6457038_8	1046714.AMRX01000007_gene2252	1.587e-57	204.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,4681Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Haloacid dehalogenase-like hydrolase	nagD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.41	ko:K01101,ko:K02566	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
WZS1_k127_6457038_7	1122915.AUGY01000095_gene3603	1.857e-60	224.0	COG2200@1|root,COG2200@2|Bacteria,1UADD@1239|Firmicutes,4HCNX@91061|Bacilli,274CU@186822|Paenibacillaceae	91061|Bacilli	T	EAL-domain associated signalling protein domain	ykuI	-	-	-	-	-	-	-	-	-	-	-	EAL,YkuI_C
WZS1_k127_6457038_12	697281.Mahau_0009	2.117e-30	122.0	arCOG15062@1|root,32Y8D@2|Bacteria,1VEUQ@1239|Firmicutes,24TKJ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PQ-loop
WZS1_k127_6457038_13	761193.Runsl_5039	2.435e-10	74.0	28J5T@1|root,2Z91J@2|Bacteria,4NHGX@976|Bacteroidetes,47KK2@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6457038_4	744872.Spica_0584	4.816e-84	294.0	COG2933@1|root,COG2933@2|Bacteria,2J5R6@203691|Spirochaetes	203691|Spirochaetes	J	FtsJ-like methyltransferase	-	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
WZS1_k127_6457038_9	266117.Rxyl_1173	2.387e-57	213.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CRCY@84995|Rubrobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
WZS1_k127_6457038_3	1279009.ADICEAN_02458	5.431e-87	308.0	COG1178@1|root,COG1178@2|Bacteria,4NEG1@976|Bacteroidetes,47KD8@768503|Cytophagia	976|Bacteroidetes	U	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
WZS1_k127_6457038_0	1250278.JQNQ01000001_gene2649	7e-116	383.0	COG1840@1|root,COG1840@2|Bacteria,4NJ1Z@976|Bacteroidetes,1HXNT@117743|Flavobacteriia	976|Bacteroidetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6,SBP_bac_8
WZS1_k127_6457038_6	443143.GM18_2269	3.982e-64	241.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CSX@68525|delta/epsilon subdivisions,2X80G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c
WZS1_k127_6457038_11	903818.KI912268_gene2523	6.103e-48	186.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
WZS1_k127_6457038_2	1167006.UWK_00589	5.222e-90	316.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_3
WZS1_k127_6457038_10	472759.Nhal_0728	1.775e-50	183.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,1S4GM@1236|Gammaproteobacteria,1WYNP@135613|Chromatiales	135613|Chromatiales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
WZS1_k127_6457038_5	1297534.CAUJ01000008_gene362	1.47e-66	236.0	2DKY4@1|root,30URY@2|Bacteria,1VT7T@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DUF4037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037,NTP_transf_2
WZS1_k127_6457038_1	1189612.A33Q_4603	3.86e-108	355.0	COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,47KW5@768503|Cytophagia	976|Bacteroidetes	S	PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
WZS1_k127_6457164_1	675813.VIB_001816	1.924e-49	192.0	COG2942@1|root,COG2942@2|Bacteria,1RAGB@1224|Proteobacteria,1S34A@1236|Gammaproteobacteria,1XTMK@135623|Vibrionales	135623|Vibrionales	G	2-epimerase	VPA0780	-	-	-	-	-	-	-	-	-	-	-	GlcNAc_2-epim
WZS1_k127_6457164_0	1123274.KB899430_gene1682	4.418e-73	249.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
WZS1_k127_6458551_3	889378.Spiaf_0143	3.424e-55	199.0	COG4324@1|root,COG4324@2|Bacteria,2JA2N@203691|Spirochaetes	203691|Spirochaetes	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
WZS1_k127_6458551_2	889378.Spiaf_2505	5.583e-63	223.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	plsC	-	2.3.1.51,2.7.4.25	ko:K00655,ko:K00945	ko00240,ko00561,ko00564,ko01100,ko01110,map00240,map00561,map00564,map01100,map01110	M00052,M00089	R00158,R00512,R01665,R02241,R09381	RC00002,RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
WZS1_k127_6458551_0	1121920.AUAU01000002_gene2007	1.082e-103	352.0	COG1322@1|root,COG1322@2|Bacteria,3Y45F@57723|Acidobacteria	57723|Acidobacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
WZS1_k127_6458551_1	1410609.JHVB01000009_gene622	1.193e-63	222.0	COG0372@1|root,COG0372@2|Bacteria,2J571@203691|Spirochaetes	203691|Spirochaetes	C	citrate synthase	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
WZS1_k127_6477226_0	744872.Spica_1347	2.159e-94	324.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
WZS1_k127_6477226_1	1125700.HMPREF9195_01344	7.245e-07	51.0	COG2911@1|root,COG2911@2|Bacteria,2J5CF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Family of	-	-	-	-	-	-	-	-	-	-	-	-	TamB
WZS1_k127_6484138_2	1307761.L21SP2_1327	8.154e-69	237.0	COG0233@1|root,COG0233@2|Bacteria,2J6PZ@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
WZS1_k127_6484138_1	573413.Spirs_2865	3.839e-80	275.0	COG0264@1|root,COG0264@2|Bacteria,2J58B@203691|Spirochaetes	203691|Spirochaetes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
WZS1_k127_6484138_0	1480694.DC28_00800	7.292e-132	424.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
WZS1_k127_6484138_3	1121289.JHVL01000002_gene2423	2.104e-21	96.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,36IU5@31979|Clostridiaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
WZS1_k127_6497559_0	158190.SpiGrapes_3257	1.37e-183	583.0	COG0017@1|root,COG0017@2|Bacteria,2J5AH@203691|Spirochaetes	203691|Spirochaetes	J	Asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
WZS1_k127_6497559_4	889378.Spiaf_1697	1.137e-77	271.0	COG0009@1|root,COG0009@2|Bacteria,2J73M@203691|Spirochaetes	203691|Spirochaetes	H	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
WZS1_k127_6497559_3	889378.Spiaf_0614	1.797e-124	412.0	COG0664@1|root,COG2172@1|root,COG0664@2|Bacteria,COG2172@2|Bacteria,2J5ZY@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,cNMP_binding
WZS1_k127_6497559_2	1307761.L21SP2_0043	7.761e-136	442.0	COG3288@1|root,COG3288@2|Bacteria,2J63R@203691|Spirochaetes	203691|Spirochaetes	C	TIGRFAM NAD(P) transhydrogenase, alpha subunit	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
WZS1_k127_6497559_6	1313304.CALK_0545	1.54e-32	130.0	COG3288@1|root,COG3288@2|Bacteria	2|Bacteria	C	NAD(P)+ transhydrogenase (AB-specific) activity	pntA-2	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
WZS1_k127_6497559_1	1480694.DC28_09225	1.329e-174	560.0	COG1282@1|root,COG1282@2|Bacteria,2J693@203691|Spirochaetes	203691|Spirochaetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
WZS1_k127_6497559_5	1238450.VIBNISOn1_820079	3.058e-44	171.0	COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,1RMZ7@1236|Gammaproteobacteria,1XSJX@135623|Vibrionales	135623|Vibrionales	J	COG0564 Pseudouridylate synthases, 23S RNA-specific	truC	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.26	ko:K06175	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_2
WZS1_k127_6497559_7	1122921.KB898186_gene4916	2.435e-05	51.0	COG2247@1|root,COG3210@1|root,COG4886@1|root,COG5184@1|root,COG2247@2|Bacteria,COG3210@2|Bacteria,COG4886@2|Bacteria,COG5184@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Flg_new,SLH
WZS1_k127_6506586_0	511.JT27_01790	1.989e-118	390.0	COG3129@1|root,COG3129@2|Bacteria,1MUI4@1224|Proteobacteria,2VKKW@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Specifically methylates the adenine in position 1618 of 23S rRNA	rlmF	-	2.1.1.181	ko:K06970	-	-	R07232	RC00003,RC00335	ko00000,ko01000,ko03009	-	-	-	Methyltransf_10
WZS1_k127_6506586_1	1219045.BV98_000813	8.866e-71	250.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TSE3@28211|Alphaproteobacteria,2KDAA@204457|Sphingomonadales	204457|Sphingomonadales	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
WZS1_k127_6506586_2	1121403.AUCV01000036_gene2920	4.052e-27	115.0	COG1846@1|root,COG1846@2|Bacteria,1N244@1224|Proteobacteria,42TYY@68525|delta/epsilon subdivisions,2WQP5@28221|Deltaproteobacteria,2MM6Y@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
WZS1_k127_6511326_4	1307761.L21SP2_1717	5.488e-17	84.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
WZS1_k127_6511326_3	573413.Spirs_0638	6.587e-19	90.0	COG5450@1|root,COG5450@2|Bacteria,2J900@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
WZS1_k127_6511326_2	760192.Halhy_0811	2.146e-29	121.0	2ED24@1|root,336Z2@2|Bacteria,4P3G3@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6511326_1	316274.Haur_4409	1.219e-49	184.0	COG0500@1|root,COG2226@2|Bacteria,2G72C@200795|Chloroflexi,3761H@32061|Chloroflexia	32061|Chloroflexia	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
WZS1_k127_6511326_0	443143.GM18_2039	1.024e-99	328.0	COG0262@1|root,COG0262@2|Bacteria,1R7YJ@1224|Proteobacteria,42ZF9@68525|delta/epsilon subdivisions,2WUSX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
WZS1_k127_6542329_9	161934.XP_010670869.1	3.326e-10	62.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37T71@33090|Viridiplantae,3GHK2@35493|Streptophyta	35493|Streptophyta	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	C2,DUF4283,RVT_1,RVT_3,zf-RVT
WZS1_k127_6542329_7	3694.POPTR_0001s08490.1	5.759e-15	76.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,zf-RVT
WZS1_k127_6542329_6	3750.XP_008356535.1	1.162e-22	103.0	COG2801@1|root,KOG0017@2759|Eukaryota	3750.XP_008356535.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6542329_8	3880.AES58602	1.244e-10	62.0	COG1005@1|root,COG3344@1|root,KOG4768@2759|Eukaryota,KOG4770@2759|Eukaryota,37KUX@33090|Viridiplantae,3GHBI@35493|Streptophyta,4JTJX@91835|fabids	35493|Streptophyta	A	NADH dehydrogenase (quinone) activity	matR	-	-	-	-	-	-	-	-	-	-	-	Intron_maturas2
WZS1_k127_6542329_5	264402.Cagra.8346s0003.1.p	2.345e-26	108.0	2E3CF@1|root,2R1SP@2759|Eukaryota,383GK@33090|Viridiplantae,3GX0Z@35493|Streptophyta,3I1GY@3699|Brassicales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6542329_0	3988.XP_002534719.1	0.0	1189.0	COG3344@1|root,KOG4768@2759|Eukaryota,37KUX@33090|Viridiplantae,3GHBI@35493|Streptophyta,4JTJX@91835|fabids	35493|Streptophyta	A	NADH dehydrogenase (quinone) activity	matR	-	-	-	-	-	-	-	-	-	-	-	Intron_maturas2
WZS1_k127_6542329_1	3880.AES58602	1.503e-68	233.0	COG1005@1|root,COG3344@1|root,KOG4768@2759|Eukaryota,KOG4770@2759|Eukaryota,37KUX@33090|Viridiplantae,3GHBI@35493|Streptophyta,4JTJX@91835|fabids	35493|Streptophyta	A	NADH dehydrogenase (quinone) activity	matR	-	-	-	-	-	-	-	-	-	-	-	Intron_maturas2
WZS1_k127_6542329_3	3880.AES58606	1.877e-53	191.0	2CYJ8@1|root,2S4RZ@2759|Eukaryota,37W3F@33090|Viridiplantae,3GKHF@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6542329_4	3880.AES58606	1.8e-27	111.0	2CYJ8@1|root,2S4RZ@2759|Eukaryota,37W3F@33090|Viridiplantae,3GKHF@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6549465_0	1168034.FH5T_17120	8.698e-38	150.0	2CM5E@1|root,332ZW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6549465_1	1382304.JNIL01000001_gene1716	6.329e-09	63.0	2EH6I@1|root,33AYE@2|Bacteria,1VP74@1239|Firmicutes,4HSH5@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6551021_0	390236.BafPKo_0555	7.069e-283	878.0	COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WZS1_k127_6551021_1	1480694.DC28_08495	4.667e-05	52.0	2A8S1@1|root,30XUQ@2|Bacteria,2JB58@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_658296_1	877418.ATWV01000005_gene2547	6.265e-68	239.0	COG0159@1|root,COG0159@2|Bacteria,2J6HT@203691|Spirochaetes	203691|Spirochaetes	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
WZS1_k127_658296_0	1480694.DC28_10230	4.629e-190	600.0	COG0133@1|root,COG0133@2|Bacteria,2J5J8@203691|Spirochaetes	203691|Spirochaetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
WZS1_k127_658296_2	665571.STHERM_c01830	4.815e-14	72.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,2J5XH@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	trpF	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
WZS1_k127_658981_2	744872.Spica_2367	4.345e-60	211.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
WZS1_k127_658981_5	573413.Spirs_2243	5.48e-39	152.0	COG0693@1|root,COG0693@2|Bacteria,2J8IJ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM DJ-1 family protein	thiJ	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
WZS1_k127_658981_0	573413.Spirs_3800	1.847e-146	483.0	COG0513@1|root,COG0513@2|Bacteria,2J5U7@203691|Spirochaetes	203691|Spirochaetes	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
WZS1_k127_658981_3	873517.HMPREF1977_0940	1.167e-52	198.0	COG2755@1|root,COG2755@2|Bacteria,4NFN6@976|Bacteroidetes,1HX8X@117743|Flavobacteriia,1EQ3R@1016|Capnocytophaga	976|Bacteroidetes	E	GSCFA family	-	-	-	-	-	-	-	-	-	-	-	-	GSCFA
WZS1_k127_658981_6	744872.Spica_0200	2.804e-26	125.0	2A0Y6@1|root,30P3E@2|Bacteria,2J6V0@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_658981_4	744872.Spica_0029	9.613e-40	151.0	COG0824@1|root,COG0824@2|Bacteria,2J837@203691|Spirochaetes	203691|Spirochaetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
WZS1_k127_658981_8	56110.Oscil6304_1417	0.0003865	49.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	hglK	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
WZS1_k127_658981_1	1294142.CINTURNW_1503	4.11e-89	303.0	COG2199@1|root,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,249J7@186801|Clostridia,36VGG@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg,TPR_12
WZS1_k127_658981_7	665571.STHERM_c02720	1.549e-08	61.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
WZS1_k127_6605127_2	309801.trd_A0658	2.854e-19	100.0	COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi,27Y3V@189775|Thermomicrobia	189775|Thermomicrobia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
WZS1_k127_6605127_0	886293.Sinac_4789	2.96e-46	173.0	COG0386@1|root,COG0386@2|Bacteria,2IZ7Z@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
WZS1_k127_6605127_1	588581.Cpap_1395	4.255e-22	102.0	2C1T4@1|root,336EA@2|Bacteria,1VVT5@1239|Firmicutes,24J1U@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6607623_0	398767.Glov_3511	7.121e-196	627.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ABC transporter related	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
WZS1_k127_6607623_2	744872.Spica_1054	6.978e-13	73.0	2DHD2@1|root,2ZZ9P@2|Bacteria,2J959@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6607623_1	1278307.KB906967_gene2590	2.217e-118	395.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,2QHK2@267894|Psychromonadaceae	1236|Gammaproteobacteria	E	Aminopeptidase I zinc metalloprotease (M18)	apeB	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
WZS1_k127_6618805_0	344747.PM8797T_29298	9.438e-236	747.0	COG0243@1|root,COG0243@2|Bacteria,2IXW2@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.7.7.2	ko:K00367,ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00791,R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
WZS1_k127_6618805_1	195103.CPF_2556	4.778e-21	96.0	COG2223@1|root,COG2223@2|Bacteria,1TRS9@1239|Firmicutes,24AFE@186801|Clostridia,36DS2@31979|Clostridiaceae	186801|Clostridia	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
WZS1_k127_6639946_1	1304874.JAFY01000002_gene971	4.917e-116	388.0	COG1027@1|root,COG1027@2|Bacteria	2|Bacteria	E	Aspartate ammonia-lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS20875	FumaraseC_C,Lyase_1
WZS1_k127_6639946_0	665571.STHERM_c17970	1.735e-125	417.0	COG0486@1|root,COG0486@2|Bacteria,2J5AQ@203691|Spirochaetes	203691|Spirochaetes	S	small GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
WZS1_k127_6639946_3	744872.Spica_0882	1.044e-12	73.0	2BHG9@1|root,2ZJEX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6639946_2	1123274.KB899411_gene3131	1.639e-33	132.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_664218_0	3988.XP_002538835.1	1.397e-08	59.0	2E2Y7@1|root,2SA43@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Retrotrans_gag
WZS1_k127_664218_1	29730.Gorai.013G212800.1	2.21e-06	49.0	2EWP9@1|root,2SYFZ@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_664571_0	1242969.ATCC51562_841	9.966e-48	182.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42QWE@68525|delta/epsilon subdivisions,2YNG3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
WZS1_k127_664571_1	331678.Cphamn1_0453	2.498e-47	174.0	COG4149@1|root,COG4149@2|Bacteria,1FE0B@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM molybdate ABC transporter, inner membrane subunit	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
WZS1_k127_6660728_1	545694.TREPR_2607	4.748e-07	56.0	COG5360@1|root,COG5360@2|Bacteria,2J6PR@203691|Spirochaetes	203691|Spirochaetes	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6660728_0	1480694.DC28_14105	4.094e-109	360.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
WZS1_k127_6668674_3	243090.RB9431	2.079e-55	203.0	COG0745@1|root,COG0745@2|Bacteria	243090.RB9431|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6668674_2	1396418.BATQ01000046_gene6136	4.267e-71	260.0	COG5002@1|root,COG5002@2|Bacteria,46VKH@74201|Verrucomicrobia,2IVSI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
WZS1_k127_6668674_1	207954.MED92_09161	1.363e-104	357.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,1RQPC@1236|Gammaproteobacteria,1XJ55@135619|Oceanospirillales	135619|Oceanospirillales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
WZS1_k127_6668674_0	907348.TresaDRAFT_1212	2.766e-220	694.0	COG0166@1|root,COG0166@2|Bacteria,2J5I6@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
WZS1_k127_6677712_0	1480694.DC28_00445	5.95e-39	150.0	2EET3@1|root,338KM@2|Bacteria,2J87J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6714946_1	927704.SELR_20610	2.973e-75	263.0	COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,4H2VI@909932|Negativicutes	909932|Negativicutes	S	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity	ylqF	-	-	ko:K14540	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1
WZS1_k127_6714946_2	744872.Spica_2384	1.828e-40	155.0	2AMDJ@1|root,31C90@2|Bacteria,2J6DK@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6714946_3	1121378.KB899703_gene2350	1.924e-09	70.0	COG1470@1|root,COG1874@1|root,COG3055@1|root,COG1470@2|Bacteria,COG1874@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.2.1.97	ko:K17624	-	-	-	-	ko00000,ko01000	-	GH101	-	ASH,F5_F8_type_C,Glyco_hyd_101C,Glyco_hydro_101,He_PIG,Kelch_1,NPCBM,NPCBM_assoc
WZS1_k127_6714946_0	1125699.HMPREF9194_01189	2.577e-135	441.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
WZS1_k127_6734810_0	913865.DOT_4157	3.382e-99	338.0	COG0304@1|root,COG0304@2|Bacteria,1VSSR@1239|Firmicutes,24XJE@186801|Clostridia,266TC@186807|Peptococcaceae	186801|Clostridia	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
WZS1_k127_6734810_1	913865.DOT_4158	4.329e-49	183.0	COG0611@1|root,COG0611@2|Bacteria,1V0SM@1239|Firmicutes,24J04@186801|Clostridia	186801|Clostridia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WZS1_k127_6747846_1	1539298.JO41_07175	1.694e-135	436.0	COG3808@1|root,COG3808@2|Bacteria,2J6RD@203691|Spirochaetes	203691|Spirochaetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
WZS1_k127_6747846_2	1307761.L21SP2_2601	6.865e-87	294.0	28JYD@1|root,2Z9NN@2|Bacteria	1307761.L21SP2_2601|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6747846_0	243231.GSU1290	2.257e-151	508.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,43S4S@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Signal transducing histidine kinase homodimeric	cheA34H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
WZS1_k127_6747846_3	338966.Ppro_1608	5.281e-38	157.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43TD2@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	Tar ligand binding domain homologue	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
WZS1_k127_6758146_1	1480694.DC28_13775	2.729e-46	176.0	COG0664@1|root,COG0664@2|Bacteria,2J6BZ@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
WZS1_k127_6758146_2	1370120.AUWR01000014_gene3404	4.355e-44	169.0	COG2846@1|root,COG2846@2|Bacteria,2IKUD@201174|Actinobacteria,23DB8@1762|Mycobacteriaceae	201174|Actinobacteria	D	Domain of Unknown function (DUF542)	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
WZS1_k127_6758146_0	1480694.DC28_13780	1.798e-128	422.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
WZS1_k127_6764468_0	1539298.JO41_07265	3.895e-64	236.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
WZS1_k127_6765085_0	744872.Spica_1164	2.207e-60	221.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
WZS1_k127_6774369_2	889378.Spiaf_1953	2.25e-41	156.0	COG0034@1|root,COG0034@2|Bacteria,2J5Y2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
WZS1_k127_6774369_3	754027.HMPREF9554_00165	5.854e-34	148.0	2FBBG@1|root,343HE@2|Bacteria,2J6BN@203691|Spirochaetes	203691|Spirochaetes	S	Family of unknown function (DUF5312)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
WZS1_k127_6774369_0	889378.Spiaf_1952	1.485e-106	363.0	COG0084@1|root,COG0084@2|Bacteria,2J68W@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WZS1_k127_6774369_1	573413.Spirs_3190	8.245e-97	327.0	COG0739@1|root,COG0739@2|Bacteria,2J5SN@203691|Spirochaetes	203691|Spirochaetes	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
WZS1_k127_6774369_4	906968.Trebr_2342	5.651e-18	87.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
WZS1_k127_6786679_6	665571.STHERM_c00360	2.159e-45	179.0	COG1315@1|root,COG1315@2|Bacteria,2J5P2@203691|Spirochaetes	203691|Spirochaetes	L	PALM domain HD hydrolase domain and	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
WZS1_k127_6786679_0	1123274.KB899407_gene346	4.939e-145	469.0	COG0455@1|root,COG0455@2|Bacteria,2J5K5@203691|Spirochaetes	203691|Spirochaetes	D	ATP-binding protein	ylxH-2	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	CbiA,ParA
WZS1_k127_6786679_1	744872.Spica_0239	3.556e-129	427.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
WZS1_k127_6786679_7	573413.Spirs_0151	3.524e-44	171.0	COG1385@1|root,COG1385@2|Bacteria,2J7WH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
WZS1_k127_6786679_5	754027.HMPREF9554_00486	1.149e-55	204.0	COG1922@1|root,COG1922@2|Bacteria,2J6M5@203691|Spirochaetes	203691|Spirochaetes	M	WecB TagA CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
WZS1_k127_6786679_4	596151.DesfrDRAFT_3359	8.127e-65	236.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42NEU@68525|delta/epsilon subdivisions,2WM5E@28221|Deltaproteobacteria,2M8NR@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
WZS1_k127_6786679_2	1307761.L21SP2_0062	4.864e-92	304.0	COG1366@1|root,COG1366@2|Bacteria,2J6J8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
WZS1_k127_6786679_8	573413.Spirs_0141	3.132e-28	119.0	2E9HN@1|root,333QR@2|Bacteria,2J8QF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6786679_3	545695.TREAZ_2703	1.957e-68	240.0	COG1842@1|root,COG1842@2|Bacteria,2J5MH@203691|Spirochaetes	203691|Spirochaetes	KT	Phage shock protein A	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
WZS1_k127_6786679_9	573413.Spirs_0143	4.96e-12	74.0	COG0745@1|root,COG0745@2|Bacteria	573413.Spirs_0143|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6791229_0	1123274.KB899442_gene891	1.145e-54	214.0	COG1361@1|root,COG3210@1|root,COG3386@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG4625@2|Bacteria,2J65H@203691|Spirochaetes	203691|Spirochaetes	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6793477_0	1449050.JNLE01000003_gene2076	9.413e-89	310.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13613	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_6793477_1	981383.AEWH01000014_gene3740	4.718e-46	171.0	COG1131@1|root,COG1131@2|Bacteria,1TQEV@1239|Firmicutes,4IQCY@91061|Bacilli	91061|Bacilli	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
WZS1_k127_6796535_4	4081.Solyc11g045260.1.1	1.041e-05	48.0	28ISP@1|root,2QR3X@2759|Eukaryota,37T53@33090|Viridiplantae,3G7SE@35493|Streptophyta	35493|Streptophyta	C	One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation	psbC	-	-	ko:K02705	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	PSII
WZS1_k127_6796535_1	4098.XP_009626068.1	1.657e-71	242.0	COG0048@1|root,KOG1750@2759|Eukaryota,37UKS@33090|Viridiplantae,3GIMC@35493|Streptophyta,44T6Q@71274|asterids	35493|Streptophyta	J	Ribosomal protein S12/S23	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
WZS1_k127_6796535_0	102107.XP_008236536.1	1.878e-140	448.0	COG0356@1|root,KOG4665@2759|Eukaryota,37J5M@33090|Viridiplantae,3GEF0@35493|Streptophyta,4JSKT@91835|fabids	35493|Streptophyta	C	ATP synthase A chain	atp6-1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464	-	ko:K02126	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002,ko03029	3.A.2.1	-	-	ATP-synt_A
WZS1_k127_6796535_5	3694.POPTR_0018s13560.1	3.024e-05	47.0	COG0515@1|root,KOG1187@2759|Eukaryota,37JU9@33090|Viridiplantae,3G86R@35493|Streptophyta,4JFF8@91835|fabids	35493|Streptophyta	T	Belongs to the protein kinase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,Pkinase_Tyr
WZS1_k127_6796535_2	29730.Gorai.001G165500.1	8.075e-20	88.0	2D40E@1|root,2STF1@2759|Eukaryota,381GT@33090|Viridiplantae,3GQJZ@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6806440_3	189425.PGRAT_26210	4.625e-05	55.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
WZS1_k127_6806440_2	945713.IALB_2848	2.243e-08	65.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
WZS1_k127_6806440_0	1480694.DC28_06195	1.998e-43	171.0	COG0394@1|root,COG0394@2|Bacteria,2J9ER@203691|Spirochaetes	203691|Spirochaetes	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
WZS1_k127_6806440_1	404380.Gbem_2348	1.358e-41	155.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
WZS1_k127_6818179_0	889378.Spiaf_2722	3.209e-169	542.0	COG1875@1|root,COG1875@2|Bacteria,2J769@203691|Spirochaetes	203691|Spirochaetes	T	PIN domain	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
WZS1_k127_6818179_1	573413.Spirs_3680	6.015e-169	557.0	COG0726@1|root,COG0726@2|Bacteria,2J5Y1@203691|Spirochaetes	203691|Spirochaetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Polysacc_deac_1
WZS1_k127_6818179_2	665571.STHERM_c02390	2.444e-39	151.0	COG1516@1|root,COG1516@2|Bacteria,2J7XT@203691|Spirochaetes	203691|Spirochaetes	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
WZS1_k127_6818179_3	744872.Spica_0451	2.74e-27	117.0	2FBJ1@1|root,343Q9@2|Bacteria,2J8G6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
WZS1_k127_6818179_4	1124982.MSI_01920	1.359e-25	108.0	COG0749@1|root,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
WZS1_k127_6843755_0	889378.Spiaf_2589	1.453e-265	851.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	ACR_tran,MMPL
WZS1_k127_6843755_3	665571.STHERM_c21650	3.241e-23	113.0	COG1538@1|root,COG1538@2|Bacteria,2J5YA@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
WZS1_k127_6843755_5	255470.cbdbA1288	3.698e-15	77.0	COG1476@1|root,COG1476@2|Bacteria,2G9QI@200795|Chloroflexi,34DGV@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
WZS1_k127_6843755_4	935840.JAEQ01000001_gene3120	9.447e-20	96.0	COG0526@1|root,COG0526@2|Bacteria,1QFCG@1224|Proteobacteria,2UZDM@28211|Alphaproteobacteria,43PR6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
WZS1_k127_6843755_1	1480694.DC28_08145	4.091e-73	254.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	dipZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD,Redoxin
WZS1_k127_6883167_0	889378.Spiaf_0709	5.596e-109	357.0	COG0492@1|root,COG0492@2|Bacteria,2J7WA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
WZS1_k127_6896103_0	394503.Ccel_0862	1.737e-62	228.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_6930491_1	1480694.DC28_03005	6.442e-83	279.0	COG0150@1|root,COG0150@2|Bacteria,2J5AP@203691|Spirochaetes	203691|Spirochaetes	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WZS1_k127_6930491_0	889378.Spiaf_1953	2.976e-127	415.0	COG0034@1|root,COG0034@2|Bacteria,2J5Y2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
WZS1_k127_6936263_8	1449076.JOOE01000002_gene769	7.48e-06	52.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,2U1U0@28211|Alphaproteobacteria,2K146@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the glycosyl hydrolase 31 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4968,DUF5110,Glyco_hydro_31,PA14
WZS1_k127_6936263_3	1307761.L21SP2_3409	1.838e-52	193.0	COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes	203691|Spirochaetes	G	DNA-binding protein PTS system, IIA component	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
WZS1_k127_6936263_9	906968.Trebr_0336	1.608e-05	50.0	2AMXY@1|root,31CUX@2|Bacteria,2J8VT@203691|Spirochaetes	203691|Spirochaetes	S	SlyX	-	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
WZS1_k127_6936263_6	1123274.KB899409_gene452	5.865e-25	107.0	COG4496@1|root,COG4496@2|Bacteria,2J8GD@203691|Spirochaetes	203691|Spirochaetes	S	trp operon repressor	-	-	-	ko:K03720	-	-	-	-	ko00000,ko03000	-	-	-	Trp_repressor
WZS1_k127_6936263_4	665571.STHERM_c10140	7.681e-51	185.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	yvcI	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
WZS1_k127_6936263_7	443143.GM18_2570	9.147e-10	65.0	2EJRN@1|root,33DGE@2|Bacteria,1NKN4@1224|Proteobacteria,42XH7@68525|delta/epsilon subdivisions,2WT06@28221|Deltaproteobacteria,43VBQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6936263_5	573413.Spirs_1493	4.558e-32	138.0	COG0666@1|root,COG0666@2|Bacteria,2J70T@203691|Spirochaetes	203691|Spirochaetes	S	Ankyrin repeat protein	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
WZS1_k127_6936263_1	573413.Spirs_1496	3.777e-99	340.0	2EY6N@1|root,33RFB@2|Bacteria,2J5R2@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0164	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,UPF0164
WZS1_k127_6936263_2	744872.Spica_1052	9.986e-98	355.0	2EWYA@1|root,33Q9N@2|Bacteria,2J5N1@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6936263_0	744872.Spica_1053	2.909e-277	899.0	COG2208@1|root,COG2208@2|Bacteria,2J5MN@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,SpoIIE
WZS1_k127_6947103_3	762903.Pedsa_3416	2.644e-36	139.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,1IR6C@117747|Sphingobacteriia	976|Bacteroidetes	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
WZS1_k127_6947103_1	1173028.ANKO01000017_gene204	3.945e-71	252.0	COG0604@1|root,COG0604@2|Bacteria,1GD4E@1117|Cyanobacteria,1HEHU@1150|Oscillatoriales	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
WZS1_k127_6947103_0	889378.Spiaf_1768	1.28e-154	505.0	COG1022@1|root,COG1022@2|Bacteria,2J6MK@203691|Spirochaetes	203691|Spirochaetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
WZS1_k127_6947103_2	665571.STHERM_c16310	1.053e-67	235.0	COG0330@1|root,COG0330@2|Bacteria,2J5A8@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
WZS1_k127_6952365_2	1378168.N510_00278	5.406e-17	82.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes	1239|Firmicutes	P	P-type atpase	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
WZS1_k127_6952365_1	1304880.JAGB01000002_gene1592	6.743e-23	100.0	COG1937@1|root,COG1937@2|Bacteria	2|Bacteria	S	negative regulation of transcription, DNA-templated	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
WZS1_k127_6952365_0	243090.RB5208	4.085e-33	149.0	COG4285@1|root,COG4285@2|Bacteria,2J0H1@203682|Planctomycetes	203682|Planctomycetes	V	biotin apo-protein ligase-related	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
WZS1_k127_6952365_4	1173028.ANKO01000154_gene4735	0.000678	53.0	COG0457@1|root,COG0457@2|Bacteria	1173028.ANKO01000154_gene4735|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_6952365_3	643867.Ftrac_0100	0.0002229	48.0	COG3420@1|root,COG5184@1|root,COG3420@2|Bacteria,COG5184@2|Bacteria,4NMRB@976|Bacteroidetes,47QVY@768503|Cytophagia	976|Bacteroidetes	P	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494
WZS1_k127_6958868_0	195250.CM001776_gene1918	5.045e-110	375.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1GCX6@1117|Cyanobacteria,1GZFG@1129|Synechococcus	1117|Cyanobacteria	EH	COG0147 Anthranilate para-aminobenzoate synthases component I	-	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
WZS1_k127_6974777_3	573413.Spirs_1558	6.976e-35	134.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
WZS1_k127_6974777_2	744872.Spica_1673	1.663e-45	170.0	COG1815@1|root,COG1815@2|Bacteria,2J804@203691|Spirochaetes	203691|Spirochaetes	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
WZS1_k127_6974777_1	665571.STHERM_c09080	2.27e-71	243.0	COG1558@1|root,COG1558@2|Bacteria,2J7Q7@203691|Spirochaetes	203691|Spirochaetes	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
WZS1_k127_6974777_4	1313292.BCO_0085900	3.649e-15	79.0	COG1677@1|root,COG1677@2|Bacteria,2J8B3@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-basal body complex protein	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
WZS1_k127_6974777_0	665571.STHERM_c09100	3.93e-121	397.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
WZS1_k127_6976227_1	665571.STHERM_c19810	8.286e-20	94.0	COG1575@1|root,COG1575@2|Bacteria,2J7QM@203691|Spirochaetes	203691|Spirochaetes	H	UbiA prenyltransferase family	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
WZS1_k127_6976227_0	1123274.KB899414_gene3619	5.079e-84	306.0	COG0616@1|root,COG0616@2|Bacteria,2J6ZS@203691|Spirochaetes	203691|Spirochaetes	OU	signal peptide peptidase SppA	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
WZS1_k127_6979899_2	1476583.DEIPH_ctg004orf0089	1.801e-17	83.0	COG2761@1|root,COG2761@2|Bacteria	2|Bacteria	Q	protein disulfide oxidoreductase activity	dsbA	-	-	-	-	-	-	-	-	-	-	-	DSBA
WZS1_k127_6979899_0	906968.Trebr_0060	4.011e-44	167.0	COG0727@1|root,COG0727@2|Bacteria,2JATI@203691|Spirochaetes	203691|Spirochaetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
WZS1_k127_6979899_1	402777.KB235904_gene4545	9.281e-18	91.0	29WQP@1|root,30IBN@2|Bacteria,1G4TM@1117|Cyanobacteria,1H8EX@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2786
WZS1_k127_6985713_3	1267535.KB906767_gene4818	3.251e-39	149.0	COG3801@1|root,COG3801@2|Bacteria,3Y89M@57723|Acidobacteria	57723|Acidobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
WZS1_k127_6985713_4	406124.ACPC01000050_gene347	1.618e-27	115.0	COG4922@1|root,COG4922@2|Bacteria,1V6S2@1239|Firmicutes,4HJRI@91061|Bacilli,1ZGJ4@1386|Bacillus	91061|Bacilli	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
WZS1_k127_6985713_1	530564.Psta_3518	2.262e-53	193.0	COG3832@1|root,COG3832@2|Bacteria,2J16I@203682|Planctomycetes	203682|Planctomycetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
WZS1_k127_6985713_2	530564.Psta_3519	2.356e-44	163.0	COG0640@1|root,COG0640@2|Bacteria,2J0DW@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
WZS1_k127_6985713_0	935840.JAEQ01000012_gene1685	1.821e-57	203.0	COG0346@1|root,COG0346@2|Bacteria,1RIAM@1224|Proteobacteria,2U9TG@28211|Alphaproteobacteria,43MEK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
WZS1_k127_6994528_3	1123242.JH636435_gene1277	2.75e-51	190.0	COG1194@1|root,COG1194@2|Bacteria,2IY33@203682|Planctomycetes	203682|Planctomycetes	L	COG1194 A G-specific DNA glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
WZS1_k127_6994528_4	953739.SVEN_5925	2.978e-05	52.0	COG2062@1|root,COG2062@2|Bacteria,2IFF3@201174|Actinobacteria	201174|Actinobacteria	T	Histidine phosphatase superfamily (branch 1)	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
WZS1_k127_6994528_0	1123274.KB899414_gene3721	3.847e-191	609.0	COG1640@1|root,COG1640@2|Bacteria,2J5U4@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
WZS1_k127_6994528_2	744872.Spica_0222	4.348e-60	211.0	COG0653@1|root,COG3012@1|root,COG0653@2|Bacteria,COG3012@2|Bacteria,2J7G8@203691|Spirochaetes	203691|Spirochaetes	U	SEC-C domain protein	-	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
WZS1_k127_6994528_1	573413.Spirs_4110	3.698e-64	229.0	COG1132@1|root,COG1132@2|Bacteria,2J5E3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WZS1_k127_6995182_0	394503.Ccel_0862	1.169e-78	287.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_7002193_0	243275.TDE_1558	5.495e-24	114.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
WZS1_k127_7028800_2	592015.HMPREF1705_01975	0.0001385	46.0	2EFZF@1|root,339RM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7028800_1	909663.KI867150_gene185	3.291e-44	171.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,42S9S@68525|delta/epsilon subdivisions,2WNSD@28221|Deltaproteobacteria,2MQQV@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD2	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
WZS1_k127_7028800_0	589865.DaAHT2_1680	7.617e-91	308.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2MHVY@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
WZS1_k127_704339_0	665571.STHERM_c10240	0.0	1523.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2J5WW@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
WZS1_k127_704339_3	1123274.KB899415_gene2416	4.558e-199	636.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
WZS1_k127_704339_9	744872.Spica_0779	2.688e-68	253.0	2F10I@1|root,33U21@2|Bacteria,2J5K0@203691|Spirochaetes	203691|Spirochaetes	S	Family of unknown function (DUF5312)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
WZS1_k127_704339_4	768670.Calni_0490	1.221e-179	576.0	COG0119@1|root,COG0119@2|Bacteria,2GF3Q@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
WZS1_k127_704339_2	1480694.DC28_01260	1.528e-221	698.0	COG0119@1|root,COG0119@2|Bacteria,2J6AF@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
WZS1_k127_704339_13	403833.Pmob_0440	9.045e-37	144.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	argO	-	2.3.1.1	ko:K03826,ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
WZS1_k127_704339_11	757424.Hsero_0984	6.021e-60	214.0	COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria,4742W@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	YaeQ	yaeQ	-	-	-	-	-	-	-	-	-	-	-	YaeQ
WZS1_k127_704339_5	744872.Spica_0084	7.767e-127	417.0	COG3392@1|root,COG3392@2|Bacteria,2J5IE@203691|Spirochaetes	203691|Spirochaetes	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
WZS1_k127_704339_6	744872.Spica_0935	1.536e-109	363.0	COG1693@1|root,COG1693@2|Bacteria	2|Bacteria	K	Ribonuclease R winged-helix domain protein	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
WZS1_k127_704339_1	589865.DaAHT2_0126	6.151e-235	732.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MIKK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
WZS1_k127_704339_14	926554.KI912639_gene1674	5.71e-15	89.0	COG1520@1|root,COG1520@2|Bacteria,1WMGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
WZS1_k127_704339_10	545695.TREAZ_0275	5.828e-61	224.0	COG2265@1|root,COG2265@2|Bacteria,2J5Y7@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	ygcA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
WZS1_k127_704339_12	573413.Spirs_1723	7.714e-51	192.0	COG1829@1|root,COG1829@2|Bacteria	2|Bacteria	S	kinase activity	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
WZS1_k127_704339_7	768672.Desfe_0418	2.748e-85	289.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
WZS1_k127_704339_8	1123274.KB899428_gene1837	2.52e-74	258.0	COG0413@1|root,COG0413@2|Bacteria,2J6TG@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
WZS1_k127_7097618_1	518766.Rmar_2599	3.567e-26	121.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes	976|Bacteroidetes	K	transcriptional regulator (AraC family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
WZS1_k127_7097618_0	357808.RoseRS_3212	4.442e-67	235.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2G6C9@200795|Chloroflexi,37685@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
WZS1_k127_7114666_4	696747.NIES39_O03970	3.31e-26	125.0	COG1074@1|root,COG1074@2|Bacteria,1G4R0@1117|Cyanobacteria,1HE61@1150|Oscillatoriales	1117|Cyanobacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
WZS1_k127_7114666_2	56780.SYN_02553	5.36e-53	214.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,2MQWD@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Exodeoxyribonuclease V, gamma subunit	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
WZS1_k127_7114666_0	889378.Spiaf_1857	3.868e-109	379.0	COG0643@1|root,COG0643@2|Bacteria,2J7QF@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-like ATPases	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c
WZS1_k127_7114666_3	889378.Spiaf_1855	3.78e-41	156.0	COG0745@1|root,COG0745@2|Bacteria	889378.Spiaf_1855|-	T	phosphorelay signal transduction system	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	-
WZS1_k127_7114666_1	744872.Spica_2493	1.597e-68	241.0	COG1262@1|root,COG1262@2|Bacteria,2J5Y8@203691|Spirochaetes	203691|Spirochaetes	C	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Flavodoxin_4
WZS1_k127_7117430_1	1122971.BAME01000164_gene6628	5.574e-18	83.0	2DMHR@1|root,32RMI@2|Bacteria,4NUR9@976|Bacteroidetes,2FT84@200643|Bacteroidia,230K6@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7117430_2	1250232.JQNJ01000001_gene687	4.931e-12	67.0	2EHME@1|root,33BD6@2|Bacteria,4NY3V@976|Bacteroidetes,1I6JF@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7117430_0	1115515.EV102420_45_00015	3.322e-19	87.0	2DRVE@1|root,33D8G@2|Bacteria,1P1ND@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7126219_5	29730.Gorai.001G166200.1	1.972e-11	66.0	2EY1V@1|root,2SZM9@2759|Eukaryota,382EN@33090|Viridiplantae,3GMWC@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7126219_3	3880.AES58520	1.407e-16	79.0	2EY1V@1|root,2SZM9@2759|Eukaryota,382EN@33090|Viridiplantae,3GMWC@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7126219_1	3880.AES58520	1.726e-18	86.0	2EY1V@1|root,2SZM9@2759|Eukaryota,382EN@33090|Viridiplantae,3GMWC@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7126219_8	3712.Bo01891s010.1	0.0005123	43.0	COG1008@1|root,KOG4845@2759|Eukaryota	2759|Eukaryota	C	NADH dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7126219_2	71139.XP_010045791.1	8.313e-18	88.0	COG2801@1|root,KOG0017@2759|Eukaryota	71139.XP_010045791.1|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7126219_6	3641.EOY18805	5.057e-05	48.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3833J@33090|Viridiplantae,3GRFX@35493|Streptophyta	35493|Streptophyta	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7126219_4	4538.ORGLA02G0339400.1	5.631e-15	78.0	28IP8@1|root,2QR09@2759|Eukaryota,37PUB@33090|Viridiplantae,3GEYD@35493|Streptophyta,3KU18@4447|Liliopsida,3I8VI@38820|Poales	35493|Streptophyta	C	Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors	psbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.10.3.9	ko:K02703	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Photo_RC
WZS1_k127_7126219_0	88036.ADH10418	7.406e-23	98.0	28IP8@1|root,2QR09@2759|Eukaryota,37PUB@33090|Viridiplantae,3GEYD@35493|Streptophyta	35493|Streptophyta	C	Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors	psbA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0010287,GO:0016020,GO:0016168,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0046906,GO:0048037,GO:0055035,GO:0097159,GO:1901363	1.10.3.9	ko:K02703	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Photo_RC
WZS1_k127_7133811_0	1242864.D187_001045	1.297e-204	695.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,2YU2V@29|Myxococcales	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	RCC1
WZS1_k127_7133881_9	665571.STHERM_c09650	5.807e-10	66.0	COG0860@1|root,COG0860@2|Bacteria,2J5PE@203691|Spirochaetes	203691|Spirochaetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1
WZS1_k127_7133881_1	665571.STHERM_c09640	1.407e-96	333.0	COG1181@1|root,COG1181@2|Bacteria,2J5KK@203691|Spirochaetes	203691|Spirochaetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4
WZS1_k127_7133881_3	877418.ATWV01000001_gene1469	4.393e-80	289.0	COG1861@1|root,COG2227@1|root,COG1861@2|Bacteria,COG2227@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
WZS1_k127_7133881_5	665571.STHERM_c09620	1.925e-51	190.0	COG1861@1|root,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
WZS1_k127_7133881_4	889378.Spiaf_1678	1.998e-53	200.0	COG1216@1|root,COG1216@2|Bacteria,2J6ET@203691|Spirochaetes	203691|Spirochaetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7133881_2	744872.Spica_1637	2.173e-92	322.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
WZS1_k127_7133881_0	1125699.HMPREF9194_00867	9.362e-117	388.0	COG1570@1|root,COG1570@2|Bacteria,2J5ED@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
WZS1_k127_7133881_7	889378.Spiaf_1681	6.906e-19	89.0	COG1722@1|root,COG1722@2|Bacteria,2J8TJ@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
WZS1_k127_7133881_6	889378.Spiaf_1682	3.786e-29	122.0	COG1430@1|root,COG1430@2|Bacteria,2J80F@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
WZS1_k127_7140313_0	1123274.KB899436_gene1284	1.393e-49	197.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
WZS1_k127_7188291_5	1198452.Jab_1c08880	3.083e-39	165.0	COG0457@1|root,COG2199@1|root,COG2203@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1R2E9@1224|Proteobacteria	1224|Proteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,TPR_12
WZS1_k127_7188291_7	665571.STHERM_c06930	5.842e-27	113.0	COG1716@1|root,COG1716@2|Bacteria,2J7PU@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG1716 FOG FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
WZS1_k127_7188291_1	1307761.L21SP2_0813	1.998e-86	302.0	COG0617@1|root,COG0617@2|Bacteria,2J5VH@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
WZS1_k127_7188291_0	509191.AEDB02000035_gene2132	3.822e-103	342.0	COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,3WIFS@541000|Ruminococcaceae	186801|Clostridia	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
WZS1_k127_7188291_3	1121335.Clst_2321	4.007e-79	268.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,3WIFG@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
WZS1_k127_7188291_2	720554.Clocl_0069	4.264e-83	281.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,3WHAI@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
WZS1_k127_7188291_6	1292035.H476_1908	3.327e-29	127.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
WZS1_k127_7188291_4	720554.Clocl_0067	7.372e-43	160.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3WGC0@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
WZS1_k127_7189022_1	649638.Trad_1393	8.665e-22	100.0	COG1848@1|root,COG1848@2|Bacteria,1WN3V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
WZS1_k127_7189022_0	479431.Namu_1913	1.478e-139	451.0	COG0371@1|root,COG0371@2|Bacteria,2GKWA@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	gldA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
WZS1_k127_7189022_2	1120999.JONM01000014_gene2854	1.837e-11	64.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,2VKI3@28216|Betaproteobacteria,2KSU1@206351|Neisseriales	206351|Neisseriales	G	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
WZS1_k127_7192396_0	906968.Trebr_1020	1.229e-06	61.0	2EMQ9@1|root,33FCS@2|Bacteria	2|Bacteria	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
WZS1_k127_7203232_4	755732.Fluta_1023	1.199e-26	111.0	COG4990@1|root,COG4990@2|Bacteria,4NFZX@976|Bacteroidetes,1HXZ6@117743|Flavobacteriia	976|Bacteroidetes	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
WZS1_k127_7203232_3	926569.ANT_20960	1.364e-55	206.0	COG0803@1|root,COG0803@2|Bacteria,2G6XK@200795|Chloroflexi	200795|Chloroflexi	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
WZS1_k127_7203232_2	383372.Rcas_1590	4.539e-74	258.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi,377ZC@32061|Chloroflexia	32061|Chloroflexia	P	PFAM ABC transporter related	-	-	-	ko:K09820	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
WZS1_k127_7203232_1	383372.Rcas_1589	2.423e-89	302.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,376AB@32061|Chloroflexia	32061|Chloroflexia	P	ABC-3 protein	-	-	-	ko:K09819	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
WZS1_k127_7203232_0	744872.Spica_0853	1.074e-185	593.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
WZS1_k127_7206751_7	1408473.JHXO01000009_gene3474	2.532e-32	131.0	2E6GM@1|root,3313V@2|Bacteria,4NT39@976|Bacteroidetes,2FZCY@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7206751_8	871968.DESME_08460	7.025e-32	129.0	COG2764@1|root,COG2764@2|Bacteria,1V3WE@1239|Firmicutes,24KMD@186801|Clostridia,262G8@186807|Peptococcaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
WZS1_k127_7206751_4	1480694.DC28_04640	9.394e-92	310.0	COG1159@1|root,COG1159@2|Bacteria,2J671@203691|Spirochaetes	203691|Spirochaetes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
WZS1_k127_7206751_6	573413.Spirs_3670	5.705e-59	223.0	COG3437@1|root,COG3437@2|Bacteria,2JBCG@203691|Spirochaetes	203691|Spirochaetes	KT	COGs COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,PAS_9
WZS1_k127_7206751_5	906968.Trebr_0606	5.999e-82	278.0	COG0740@1|root,COG0740@2|Bacteria,2J78H@203691|Spirochaetes	203691|Spirochaetes	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP-2	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
WZS1_k127_7206751_2	1307761.L21SP2_2844	6.778e-98	329.0	COG0152@1|root,COG0152@2|Bacteria,2J6XZ@203691|Spirochaetes	203691|Spirochaetes	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
WZS1_k127_7206751_9	158189.SpiBuddy_2318	1.194e-30	133.0	COG3568@1|root,COG3568@2|Bacteria,2J7FP@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Endonuclease Exonuclease phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
WZS1_k127_7206751_0	1480694.DC28_04025	2.671e-140	457.0	COG1364@1|root,COG1364@2|Bacteria,2J5IC@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
WZS1_k127_7206751_1	1307761.L21SP2_2838	1.054e-123	406.0	COG0714@1|root,COG0714@2|Bacteria,2J5VG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
WZS1_k127_7206751_3	1123274.KB899408_gene3777	6.819e-95	319.0	COG1721@1|root,COG1721@2|Bacteria,2J6XP@203691|Spirochaetes	203691|Spirochaetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WZS1_k127_7206751_10	889378.Spiaf_2535	3.796e-22	107.0	2DR3K@1|root,33A0U@2|Bacteria,2J9GN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7206751_11	1480694.DC28_04005	5.19e-06	49.0	COG2304@1|root,COG2304@2|Bacteria,2J6JM@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
WZS1_k127_7215259_0	1449050.JNLE01000003_gene2076	6.381e-208	677.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13613	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_7215339_0	760192.Halhy_4298	1.35e-84	299.0	COG0714@1|root,COG0714@2|Bacteria,4NIHC@976|Bacteroidetes,1IQRD@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM ATPase associated with various cellular activities	ravA_1	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
WZS1_k127_7215339_1	1480694.DC28_12525	2.15e-45	182.0	COG2425@1|root,COG2425@2|Bacteria,2J7RW@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2,VWA_CoxE
WZS1_k127_7219491_0	909663.KI867150_gene476	0.0	1145.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,43789@68525|delta/epsilon subdivisions,2X2AW@28221|Deltaproteobacteria,2MS3Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
WZS1_k127_7219491_1	1307761.L21SP2_0023	1.247e-202	649.0	COG1640@1|root,COG1640@2|Bacteria,2J62I@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
WZS1_k127_7219491_6	573413.Spirs_0267	3.64e-51	187.0	COG1259@1|root,COG1259@2|Bacteria,2J813@203691|Spirochaetes	203691|Spirochaetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
WZS1_k127_7219491_7	398512.JQKC01000033_gene5016	0.0002559	46.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3WGDE@541000|Ruminococcaceae	186801|Clostridia	NU	type II secretion system protein E	xcpR	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
WZS1_k127_7219491_3	1294142.CINTURNW_0693	3.887e-148	480.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
WZS1_k127_7219491_4	744872.Spica_0162	1.771e-101	341.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
WZS1_k127_7219491_5	1480694.DC28_09095	1.74e-79	273.0	COG0047@1|root,COG0047@2|Bacteria,2J8JD@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	-	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
WZS1_k127_7219491_2	1307761.L21SP2_0016	8.857e-169	544.0	COG0046@1|root,COG0046@2|Bacteria,2J66J@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
WZS1_k127_7226310_6	926550.CLDAP_20910	0.0001586	55.0	COG1319@1|root,COG3266@1|root,COG3391@1|root,COG1319@2|Bacteria,COG3266@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.2.1.91	ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000	-	GH6	-	FAD_binding_5
WZS1_k127_7226310_3	1123274.KB899427_gene3349	5.629e-21	100.0	2ANXJ@1|root,31DYA@2|Bacteria,2JB64@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7226310_1	1480694.DC28_13550	2.142e-63	221.0	COG0386@1|root,COG0386@2|Bacteria,2J843@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
WZS1_k127_7226310_0	1232410.KI421418_gene2422	7.086e-68	235.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	SelR domain	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
WZS1_k127_7226310_4	1123274.KB899427_gene3349	6.868e-19	93.0	2ANXJ@1|root,31DYA@2|Bacteria,2JB64@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7226310_5	269798.CHU_1732	4.197e-06	58.0	2FAQ9@1|root,342XQ@2|Bacteria,4P4VS@976|Bacteroidetes,47VBC@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7226310_2	545695.TREAZ_1844	7.271e-41	156.0	COG2318@1|root,COG2318@2|Bacteria,2J94Z@203691|Spirochaetes	203691|Spirochaetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
WZS1_k127_7239168_0	443143.GM18_0324	2.991e-216	676.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,43VCE@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
WZS1_k127_7241350_2	573061.Clocel_3423	3.351e-60	219.0	COG0697@1|root,COG0697@2|Bacteria,1TRKD@1239|Firmicutes,248I1@186801|Clostridia,36ENQ@31979|Clostridiaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
WZS1_k127_7241350_1	744872.Spica_2781	1.101e-63	227.0	COG0613@1|root,COG0613@2|Bacteria,2J7WK@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP,PHP_C
WZS1_k127_7241350_3	1304885.AUEY01000016_gene3066	1.64e-41	162.0	COG0834@1|root,COG0834@2|Bacteria,1R4SQ@1224|Proteobacteria,42T9E@68525|delta/epsilon subdivisions,2WPWJ@28221|Deltaproteobacteria,2MNPF@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
WZS1_k127_7241350_4	1408473.JHXO01000011_gene2983	9.979e-37	141.0	COG3070@1|root,COG3070@2|Bacteria,4NQWP@976|Bacteroidetes,2FTFF@200643|Bacteroidia	976|Bacteroidetes	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
WZS1_k127_7241350_0	665571.STHERM_c16630	0.0	1623.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
WZS1_k127_7241350_5	1307761.L21SP2_2920	1.879e-26	112.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2J6HE@203691|Spirochaetes	203691|Spirochaetes	F	Orotidine 5''-phosphate decarboxylase	pyrF	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
WZS1_k127_7248633_0	5145.XP_001907059.1	0.0	1092.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi,3QP1S@4890|Ascomycota,2126Z@147550|Sordariomycetes,3UASY@5139|Sordariales	4751|Fungi	L	WGS project CABT00000000 data, contig	-	GO:0003674,GO:0003824,GO:0003964,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Chromo,Peptidase_A2E,RVT_1,rve
WZS1_k127_7248633_2	5111.M1WD20	5.642e-09	70.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi,3QP1S@4890|Ascomycota,21F6C@147550|Sordariomycetes,3TQCB@5125|Hypocreales,3G5ZQ@34397|Clavicipitaceae	4751|Fungi	L	to reverse transcriptase	-	GO:0003674,GO:0003824,GO:0003964,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Peptidase_A2E,RVT_1,Retrotrans_gag,rve,zf-CCHC
WZS1_k127_7248633_1	5145.XP_001907059.1	1.264e-42	161.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi,3QP1S@4890|Ascomycota,2126Z@147550|Sordariomycetes,3UASY@5139|Sordariales	4751|Fungi	L	WGS project CABT00000000 data, contig	-	GO:0003674,GO:0003824,GO:0003964,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Chromo,Peptidase_A2E,RVT_1,rve
WZS1_k127_7256161_2	1480694.DC28_00345	3.179e-36	147.0	COG2214@1|root,COG2214@2|Bacteria,2J5G9@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
WZS1_k127_7256161_1	665571.STHERM_c11380	2.057e-42	160.0	COG0691@1|root,COG0691@2|Bacteria,2J78Q@203691|Spirochaetes	203691|Spirochaetes	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
WZS1_k127_7256161_3	744872.Spica_1299	5.775e-20	104.0	COG1262@1|root,COG1262@2|Bacteria,2J67Z@203691|Spirochaetes	203691|Spirochaetes	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
WZS1_k127_7256161_0	545695.TREAZ_0416	5.152e-53	193.0	COG0681@1|root,COG0681@2|Bacteria,2J6RU@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB-2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
WZS1_k127_7258399_1	1536772.R70723_20560	1.441e-126	452.0	COG0515@1|root,COG2199@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1UI4Q@1239|Firmicutes,4HP00@91061|Bacilli,274BV@186822|Paenibacillaceae	91061|Bacilli	KLT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GGDEF,PAS_8,PAS_9,Pkinase
WZS1_k127_7258399_3	641491.DND132_0924	1.453e-44	171.0	COG0834@1|root,COG0834@2|Bacteria,1QN3T@1224|Proteobacteria,42T33@68525|delta/epsilon subdivisions,2WPK9@28221|Deltaproteobacteria,2MEXG@213115|Desulfovibrionales	28221|Deltaproteobacteria	ET	PFAM Extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
WZS1_k127_7258399_0	1111479.AXAR01000001_gene429	8.802e-134	434.0	COG1357@1|root,COG1357@2|Bacteria,1TR7H@1239|Firmicutes,4IPNR@91061|Bacilli	91061|Bacilli	S	Pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
WZS1_k127_7258399_2	1356854.N007_19870	1.343e-60	212.0	COG1695@1|root,COG1695@2|Bacteria,1VA94@1239|Firmicutes,4HJKS@91061|Bacilli,27ABN@186823|Alicyclobacillaceae	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
WZS1_k127_7258704_3	545695.TREAZ_1636	2.219e-06	50.0	COG1639@1|root,COG1639@2|Bacteria,2J74B@203691|Spirochaetes	203691|Spirochaetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
WZS1_k127_7258704_1	744872.Spica_2727	2.554e-96	349.0	COG0457@1|root,COG0457@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
WZS1_k127_7258704_2	1123274.KB899414_gene3682	2.238e-78	281.0	COG4733@1|root,COG4733@2|Bacteria,2JBHZ@203691|Spirochaetes	203691|Spirochaetes	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,fn3
WZS1_k127_7258704_0	573413.Spirs_4068	9.176e-103	342.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
WZS1_k127_7267327_0	545694.TREPR_1075	8.425e-197	623.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
WZS1_k127_7267327_3	1307761.L21SP2_2213	7.646e-53	196.0	COG0345@1|root,COG0345@2|Bacteria,2J6DB@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
WZS1_k127_7267327_4	411465.PEPMIC_00132	5.93e-45	171.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,22HJP@1570339|Peptoniphilaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
WZS1_k127_7267327_2	573413.Spirs_1827	9.207e-61	233.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,2J9V6@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,HATPase_c,HisKA,PAS,PAS_9,Response_reg
WZS1_k127_7267327_1	665571.STHERM_c21550	3.366e-102	341.0	COG0331@1|root,COG0331@2|Bacteria,2J5E6@203691|Spirochaetes	203691|Spirochaetes	I	Malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
WZS1_k127_7292633_1	1286171.EAL2_c07480	3.317e-63	219.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia	186801|Clostridia	L	PFAM DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
WZS1_k127_7292633_0	665571.STHERM_c03300	5.383e-66	241.0	COG3391@1|root,COG3391@2|Bacteria,2J5ZD@203691|Spirochaetes	203691|Spirochaetes	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
WZS1_k127_7292633_2	1123274.KB899422_gene77	1.173e-31	129.0	COG1293@1|root,COG1293@2|Bacteria,2J61Z@203691|Spirochaetes	203691|Spirochaetes	K	Fibrinogen-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
WZS1_k127_730391_6	4081.Solyc10g061880.1.1	2.153e-24	103.0	2CKIM@1|root,2SWMP@2759|Eukaryota,381WT@33090|Viridiplantae,3GRR6@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_10	161934.XP_010671929.1	4.348e-14	78.0	COG2801@1|root,KOG0017@2759|Eukaryota,37YGB@33090|Viridiplantae,3GNQA@35493|Streptophyta	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotrans_gag
WZS1_k127_730391_16	29760.VIT_00s0733g00010.t01	5.973e-09	57.0	COG0056@1|root,KOG1353@2759|Eukaryota,37JWW@33090|Viridiplantae,3G9FP@35493|Streptophyta	35493|Streptophyta	C	ATP synthase subunit alpha	-	-	-	ko:K02132	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
WZS1_k127_730391_21	4006.Lus10025569	2.05e-05	50.0	COG5077@1|root,KOG1863@2759|Eukaryota,37IFY@33090|Viridiplantae,3G74J@35493|Streptophyta,4JFE0@91835|fabids	35493|Streptophyta	O	Ubiquitin carboxyl-terminal hydrolase	-	GO:0001101,GO:0003674,GO:0003824,GO:0004843,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005911,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009506,GO:0009719,GO:0009725,GO:0009753,GO:0009755,GO:0009867,GO:0009987,GO:0010033,GO:0016787,GO:0019538,GO:0019783,GO:0023052,GO:0030054,GO:0032870,GO:0036459,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055044,GO:0065007,GO:0070011,GO:0070887,GO:0071229,GO:0071310,GO:0071395,GO:0071495,GO:0071704,GO:0101005,GO:0140096,GO:1901564,GO:1901700,GO:1901701	-	-	-	-	-	-	-	-	-	-	MATH,RVT_3
WZS1_k127_730391_23	161934.XP_010670869.1	0.0001026	48.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37T71@33090|Viridiplantae,3GHK2@35493|Streptophyta	35493|Streptophyta	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	C2,DUF4283,RVT_1,RVT_3,zf-RVT
WZS1_k127_730391_14	2711.XP_006480844.1	7.037e-11	64.0	KOG1075@1|root,KOG1075@2759|Eukaryota,37ZUV@33090|Viridiplantae,3GE1G@35493|Streptophyta	35493|Streptophyta	S	Ribonuclease H	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3,zf-RVT
WZS1_k127_730391_1	4081.Solyc00g020040.1.1	6.088e-113	366.0	2C63N@1|root,2QT9Q@2759|Eukaryota,37P22@33090|Viridiplantae,3GH9T@35493|Streptophyta	35493|Streptophyta	-	-	ccmB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_3	29730.Gorai.001G160300.1	5.337e-39	156.0	2ESJY@1|root,2SV48@2759|Eukaryota,381J0@33090|Viridiplantae,3GQNG@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_8	4098.XP_009591347.1	5.472e-16	81.0	29ZPR@1|root,2RXWR@2759|Eukaryota,37U5T@33090|Viridiplantae,3GHWN@35493|Streptophyta,44UK9@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_11	3988.XP_002534745.1	4.024e-13	69.0	2E8KW@1|root,2SF2T@2759|Eukaryota,37XH5@33090|Viridiplantae,3GMKG@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_15	4577.GRMZM5G897615_P01	4.657e-10	60.0	2E8KW@1|root,2SF2T@2759|Eukaryota,37XH5@33090|Viridiplantae,3GMKG@35493|Streptophyta,3M9WC@4447|Liliopsida,3IQV4@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_4	72658.Bostr.9928s0004.1.p	5.084e-30	118.0	29ZPR@1|root,2RXWR@2759|Eukaryota,37U5T@33090|Viridiplantae,3GHWN@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_13	29730.Gorai.001G164300.1	4.286e-11	63.0	29ZPR@1|root,2RXWR@2759|Eukaryota,37U5T@33090|Viridiplantae,3GHWN@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_19	29730.Gorai.001G164300.1	1.466e-07	53.0	29ZPR@1|root,2RXWR@2759|Eukaryota,37U5T@33090|Viridiplantae,3GHWN@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_24	4572.TRIUR3_11948-P1	0.0001075	47.0	COG1005@1|root,KOG4770@2759|Eukaryota,37VTA@33090|Viridiplantae,3GJT6@35493|Streptophyta,3M71K@4447|Liliopsida,3IMA3@38820|Poales	35493|Streptophyta	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K03878	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADHdh
WZS1_k127_730391_2	3659.XP_004153385.1	7.749e-73	246.0	COG1005@1|root,KOG4770@2759|Eukaryota,37V23@33090|Viridiplantae,3GIN5@35493|Streptophyta	35493|Streptophyta	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	nad1	GO:0006091,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114	1.6.5.3	ko:K03878	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADHdh
WZS1_k127_730391_7	4098.XP_009603329.1	5.06e-18	86.0	29ZPR@1|root,2RXWR@2759|Eukaryota,37U5T@33090|Viridiplantae,3GHWN@35493|Streptophyta,44UK9@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_22	13333.ERN18214	5.936e-05	47.0	COG2801@1|root,KOG0017@2759|Eukaryota	13333.ERN18214|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_730391_9	102107.XP_008222569.1	3.154e-14	72.0	COG2801@1|root,KOG0017@2759|Eukaryota,37ZS9@33090|Viridiplantae,3GPEF@35493|Streptophyta	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
WZS1_k127_730391_12	4558.Sb07g023610.1	1.482e-12	68.0	COG2801@1|root,KOG0017@2759|Eukaryota,37YXJ@33090|Viridiplantae,3GHMT@35493|Streptophyta,3MAH5@4447|Liliopsida	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs
WZS1_k127_730391_20	4558.Sb05g024695.1	9.598e-06	49.0	COG2801@1|root,KOG0017@2759|Eukaryota,37V0Y@33090|Viridiplantae,3GIY6@35493|Streptophyta,3M459@4447|Liliopsida,3ITSB@38820|Poales	35493|Streptophyta	L	Pfam:UBN2_2	-	-	-	-	-	-	-	-	-	-	-	-	Retrotran_gag_2,Retrotran_gag_3,gag_pre-integrs
WZS1_k127_730391_18	3750.XP_008341155.1	1.086e-07	55.0	COG0515@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG1187@2759|Eukaryota	2759|Eukaryota	KLT	protein serine/threonine kinase activity	-	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004675,GO:0004888,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019199,GO:0019538,GO:0023052,GO:0036211,GO:0038023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.11.1	ko:K04733	ko04010,ko04064,ko04620,ko04621,ko04624,ko04722,ko05133,ko05140,ko05142,ko05145,ko05152,ko05162,ko05164,map04010,map04064,map04620,map04621,map04624,map04722,map05133,map05140,map05142,map05145,map05152,map05162,map05164	M00686	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	Pkinase,Pkinase_Tyr
WZS1_k127_730391_5	4558.Sb0013s009070.1	9.198e-26	109.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RIF@33090|Viridiplantae,3G9AM@35493|Streptophyta,3M33Z@4447|Liliopsida,3IM81@38820|Poales	35493|Streptophyta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,rve
WZS1_k127_730391_0	29730.Gorai.001G168000.1	3.772e-114	370.0	COG0839@1|root,2S14H@2759|Eukaryota,389Z6@33090|Viridiplantae,3GX82@35493|Streptophyta	35493|Streptophyta	C	Belongs to the complex I subunit 6 family	NAD6	-	1.6.5.3	ko:K03884	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q3
WZS1_k127_7322608_0	1307761.L21SP2_0338	2.789e-198	623.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
WZS1_k127_7322608_1	665571.STHERM_c16020	9.889e-145	474.0	COG2317@1|root,COG2317@2|Bacteria,2J6XW@203691|Spirochaetes	203691|Spirochaetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
WZS1_k127_7344762_2	421052.F945_00484	2.352e-22	102.0	2DYTW@1|root,34B31@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7344762_3	744872.Spica_1754	4.666e-21	94.0	COG2161@1|root,COG2161@2|Bacteria,2J8SD@203691|Spirochaetes	203691|Spirochaetes	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
WZS1_k127_7344762_4	744872.Spica_1746	1.118e-20	96.0	COG3668@1|root,COG3668@2|Bacteria,2J9DR@203691|Spirochaetes	203691|Spirochaetes	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
WZS1_k127_7344762_0	1117647.M5M_13920	2.488e-49	178.0	COG5646@1|root,COG5646@2|Bacteria,1N60V@1224|Proteobacteria	1224|Proteobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WZS1_k127_7344762_1	1121007.AUML01000001_gene1308	3.984e-31	128.0	2CJSZ@1|root,32XRW@2|Bacteria,4P6KZ@976|Bacteroidetes,1IHWR@117743|Flavobacteriia,2YK2R@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7345361_0	665571.STHERM_c05990	3.864e-116	391.0	COG2256@1|root,COG2256@2|Bacteria,2J604@203691|Spirochaetes	203691|Spirochaetes	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
WZS1_k127_7345361_1	518766.Rmar_1256	5.3e-67	243.0	COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,1FJ56@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
WZS1_k127_7362798_0	1286632.P278_26240	1.477e-46	176.0	COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,1HX4X@117743|Flavobacteriia	976|Bacteroidetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
WZS1_k127_7365926_2	2903.EOD31626	3.024e-08	65.0	KOG4441@1|root,KOG4441@2759|Eukaryota	2759|Eukaryota	KLT	protein ubiquitination	-	-	-	ko:K10454,ko:K10457	-	-	-	-	ko00000,ko04121	-	-	-	Kelch_1
WZS1_k127_7365926_0	324925.Ppha_0149	5.77e-242	758.0	COG0369@1|root,COG1151@2|Bacteria,1FD7I@1090|Chlorobi	1090|Chlorobi	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
WZS1_k127_7365926_1	1307761.L21SP2_0514	2.519e-85	294.0	COG1145@1|root,COG1145@2|Bacteria,2J684@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
WZS1_k127_7368136_1	1195236.CTER_5446	6.321e-07	57.0	COG0457@1|root,COG0457@2|Bacteria,1VRBV@1239|Firmicutes,25DTX@186801|Clostridia	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
WZS1_k127_7368136_0	1121904.ARBP01000005_gene4676	8.941e-134	435.0	COG0012@1|root,COG0012@2|Bacteria,4NF7N@976|Bacteroidetes,47KXT@768503|Cytophagia	976|Bacteroidetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
WZS1_k127_7375820_0	203124.Tery_2417	1.811e-70	255.0	COG2114@1|root,COG2202@1|root,COG4191@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769,ko:K11959	ko00230,ko02010,ko02025,ko04113,ko04213,map00230,map02010,map02025,map04113,map04213	M00323,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Guanylate_cyc,PAS_4,PAS_9,Peripla_BP_5
WZS1_k127_7375820_1	1121324.CLIT_2c00100	9.804e-14	78.0	COG2199@1|root,COG2703@1|root,COG2703@2|Bacteria,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	2.7.7.65	ko:K18967	-	-	-	-	ko00000,ko01000,ko02000	9.B.34.1.1	-	-	GGDEF,PAS,PAS_9,PocR
WZS1_k127_7376248_1	362663.ECP_4579	3.035e-09	63.0	2AKTD@1|root,31BKE@2|Bacteria,1RHGN@1224|Proteobacteria,1S6F8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7377994_0	1480694.DC28_08440	3.585e-79	278.0	COG0517@1|root,COG2208@1|root,COG0517@2|Bacteria,COG2208@2|Bacteria,2J846@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
WZS1_k127_7377994_1	545694.TREPR_0851	3.558e-05	54.0	COG2843@1|root,COG2843@2|Bacteria,2J77A@203691|Spirochaetes	203691|Spirochaetes	M	Bacterial capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
WZS1_k127_7390587_10	665571.STHERM_c11090	1.243e-12	70.0	COG0728@1|root,COG0728@2|Bacteria,2J697@203691|Spirochaetes	203691|Spirochaetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
WZS1_k127_7390587_8	573413.Spirs_3486	6.1e-39	148.0	COG0640@1|root,COG0640@2|Bacteria,2J6BT@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory protein, arsR family	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,HTH_5
WZS1_k127_7390587_0	158190.SpiGrapes_2803	2.025e-247	784.0	COG2217@1|root,COG2217@2|Bacteria,2J5T8@203691|Spirochaetes	203691|Spirochaetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
WZS1_k127_7390587_4	1307761.L21SP2_2448	1.687e-63	226.0	COG1272@1|root,COG1272@2|Bacteria,2J5IS@203691|Spirochaetes	203691|Spirochaetes	S	channel protein, hemolysin III family	yplQ	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
WZS1_k127_7390587_1	504728.K649_00095	1.184e-146	496.0	COG1643@1|root,COG1643@2|Bacteria,1WINM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
WZS1_k127_7390587_3	1307761.L21SP2_1835	6.903e-81	277.0	COG0483@1|root,COG0483@2|Bacteria,2J924@203691|Spirochaetes	203691|Spirochaetes	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
WZS1_k127_7390587_5	1480694.DC28_07540	5.4e-55	199.0	COG2095@1|root,COG2095@2|Bacteria	2|Bacteria	U	MarC family integral membrane protein	IV02_12955	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
WZS1_k127_7390587_9	37659.JNLN01000001_gene608	1.253e-33	141.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia,36EBC@31979|Clostridiaceae	186801|Clostridia	V	PFAM peptidase U61, LD-carboxypeptidase A	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
WZS1_k127_7390587_7	635013.TherJR_0664	3.885e-39	149.0	COG2703@1|root,COG2703@2|Bacteria,1VBEC@1239|Firmicutes,24NV2@186801|Clostridia,263CR@186807|Peptococcaceae	186801|Clostridia	P	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
WZS1_k127_7390587_2	158189.SpiBuddy_0807	1.599e-145	474.0	COG2204@1|root,COG2204@2|Bacteria,2J6EQ@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
WZS1_k127_7390587_6	1307761.L21SP2_1061	2.395e-44	172.0	COG4191@1|root,COG4191@2|Bacteria,2J87U@203691|Spirochaetes	203691|Spirochaetes	T	Signal transduction histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
WZS1_k127_7406752_0	545694.TREPR_2633	8.028e-19	102.0	COG2911@1|root,COG2911@2|Bacteria,2J5CF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Family of	-	-	-	-	-	-	-	-	-	-	-	-	TamB
WZS1_k127_7416111_1	1196322.A370_03779	6.125e-81	289.0	COG0366@1|root,COG0366@2|Bacteria,1TQSE@1239|Firmicutes,24C4V@186801|Clostridia,36H6T@31979|Clostridiaceae	186801|Clostridia	G	alpha-amylase	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26,CBM53,Y_Y_Y
WZS1_k127_7416111_0	754027.HMPREF9554_00856	4.536e-109	379.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
WZS1_k127_7421283_0	1307761.L21SP2_0730	4.562e-219	692.0	COG0008@1|root,COG0008@2|Bacteria,2J6KU@203691|Spirochaetes	203691|Spirochaetes	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
WZS1_k127_7421283_1	716544.wcw_0256	1.934e-31	138.0	COG4249@1|root,COG4249@2|Bacteria,2JH35@204428|Chlamydiae	204428|Chlamydiae	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
WZS1_k127_7421283_2	765952.PUV_13080	2.054e-20	96.0	COG4249@1|root,COG4249@2|Bacteria,2JH35@204428|Chlamydiae	204428|Chlamydiae	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
WZS1_k127_742297_1	292564.Cyagr_0222	1.572e-24	118.0	2BWQ7@1|root,33XD9@2|Bacteria,1GDXX@1117|Cyanobacteria,22RVZ@167375|Cyanobium	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_742297_0	65393.PCC7424_5190	1.792e-32	128.0	2DA6F@1|root,32TUS@2|Bacteria,1G7Y5@1117|Cyanobacteria,3KIIQ@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7431337_0	665571.STHERM_c07960	6.466e-29	117.0	COG1055@1|root,COG1055@2|Bacteria,2J6QU@203691|Spirochaetes	203691|Spirochaetes	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp
WZS1_k127_7431337_2	1238182.C882_2033	0.0009392	49.0	2EBDN@1|root,335EA@2|Bacteria,1NDTN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7431337_1	744872.Spica_2496	1.297e-28	117.0	COG0607@1|root,COG0607@2|Bacteria,2J8B4@203691|Spirochaetes	203691|Spirochaetes	P	Rhodanese Homology Domain	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
WZS1_k127_7436505_3	889378.Spiaf_2120	2.374e-78	267.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
WZS1_k127_7436505_2	545695.TREAZ_0907	4.805e-91	318.0	COG0770@1|root,COG0770@2|Bacteria,2J5GH@203691|Spirochaetes	203691|Spirochaetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
WZS1_k127_7436505_6	243275.TDE_1199	8.339e-06	52.0	2BPMB@1|root,32IEC@2|Bacteria,2J8ZG@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein, FtsL	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
WZS1_k127_7436505_1	906968.Trebr_0947	1.045e-101	340.0	COG0275@1|root,COG0275@2|Bacteria,2J6DH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
WZS1_k127_7436505_4	1480694.DC28_02230	1.343e-47	174.0	COG2001@1|root,COG2001@2|Bacteria,2J7XS@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
WZS1_k127_7436505_5	573413.Spirs_1543	1.592e-17	88.0	2AN0A@1|root,2ZDBY@2|Bacteria,2J9A6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7436505_7	635013.TherJR_1854	8.661e-05	49.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	spoIIAA	-	-	ko:K04749,ko:K20978	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko03021	-	-	-	STAS,STAS_2
WZS1_k127_7436505_0	1123274.KB899413_gene875	1.37e-160	516.0	COG1543@1|root,COG1543@2|Bacteria,2J628@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
WZS1_k127_7467949_2	1125701.HMPREF1221_02355	1.884e-12	74.0	COG1728@1|root,COG1728@2|Bacteria,2J8M6@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF327)	-	-	-	ko:K09770	-	-	-	-	ko00000	-	-	-	DUF327
WZS1_k127_7467949_0	573413.Spirs_4111	1.907e-148	490.0	COG1132@1|root,COG1132@2|Bacteria,2J5W8@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K11085,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WZS1_k127_7467949_1	573413.Spirs_4110	1.08e-121	400.0	COG1132@1|root,COG1132@2|Bacteria,2J5E3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
WZS1_k127_747030_0	1232683.ADIMK_1029	7.436e-39	161.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,464AV@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,AAA_30,UvrD_C_2
WZS1_k127_747030_1	1278307.KB906967_gene2455	2.202e-17	92.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,2QHY4@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
WZS1_k127_747705_1	760011.Spico_0514	7.396e-53	188.0	COG0335@1|root,COG0335@2|Bacteria,2J825@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
WZS1_k127_747705_0	221027.JO40_06790	1.666e-58	206.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
WZS1_k127_7477470_1	665571.STHERM_c01340	4.204e-136	438.0	COG0021@1|root,COG0021@2|Bacteria,2J6KB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
WZS1_k127_7477470_0	1480694.DC28_08815	4.359e-193	623.0	COG0855@1|root,COG0855@2|Bacteria,2J5WA@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
WZS1_k127_7480864_3	1480694.DC28_03505	5.125e-37	144.0	COG1438@1|root,COG1438@2|Bacteria,2J7NJ@203691|Spirochaetes	203691|Spirochaetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
WZS1_k127_7480864_0	1480694.DC28_03500	4.63e-114	377.0	COG0002@1|root,COG0002@2|Bacteria,2J637@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
WZS1_k127_7480864_2	665571.STHERM_c20040	3.324e-59	214.0	COG0548@1|root,COG0548@2|Bacteria,2J6RN@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
WZS1_k127_7480864_1	665571.STHERM_c20050	6.117e-88	297.0	COG4992@1|root,COG4992@2|Bacteria,2J5X2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
WZS1_k127_7508089_2	158190.SpiGrapes_2070	3.944e-41	156.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
WZS1_k127_7508089_4	545694.TREPR_1058	5.736e-32	139.0	COG1489@1|root,COG1833@1|root,COG1489@2|Bacteria,COG1833@2|Bacteria,2J70K@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the SfsA family	-	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	DUF123,SfsA
WZS1_k127_7508089_0	573413.Spirs_1501	3.154e-207	662.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
WZS1_k127_7508089_1	665571.STHERM_c08550	3.116e-57	206.0	COG0764@1|root,COG0764@2|Bacteria,2J7PK@203691|Spirochaetes	203691|Spirochaetes	I	dehydratase	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
WZS1_k127_7508089_3	744872.Spica_2041	1.043e-34	138.0	COG0511@1|root,COG0511@2|Bacteria,2J83W@203691|Spirochaetes	203691|Spirochaetes	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
WZS1_k127_7508089_5	1235798.C817_01292	7.219e-20	89.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,27VAK@189330|Dorea	186801|Clostridia	I	Psort location Cytoplasmic, score 8.87	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
WZS1_k127_7522925_3	665571.STHERM_c21970	4.253e-26	109.0	COG1925@1|root,COG1925@2|Bacteria,2J8AV@203691|Spirochaetes	203691|Spirochaetes	G	phosphocarrier protein HPr	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
WZS1_k127_7522925_0	1123274.KB899414_gene3661	6.505e-138	446.0	COG1493@1|root,COG1493@2|Bacteria,2J5JA@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
WZS1_k127_7522925_4	573413.Spirs_4049	3.57e-21	98.0	COG1544@1|root,COG1544@2|Bacteria,2J9DI@203691|Spirochaetes	203691|Spirochaetes	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
WZS1_k127_7522925_1	665571.STHERM_c21940	8.336e-130	429.0	COG1508@1|root,COG1508@2|Bacteria,2J5KV@203691|Spirochaetes	203691|Spirochaetes	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
WZS1_k127_7522925_2	889378.Spiaf_2672	5.786e-96	319.0	COG1137@1|root,COG1137@2|Bacteria,2J5CM@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
WZS1_k127_7524637_0	1480694.DC28_08300	2.878e-127	434.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
WZS1_k127_7524637_2	7739.XP_002598600.1	8.771e-13	82.0	COG5279@1|root,KOG4575@2759|Eukaryota,39WFT@33154|Opisthokonta,3BIKZ@33208|Metazoa,3D1NX@33213|Bilateria,480EJ@7711|Chordata	33208|Metazoa	D	Kyphoscoliosis peptidase	KY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0007275,GO:0007517,GO:0007528,GO:0008150,GO:0009987,GO:0016043,GO:0030016,GO:0030017,GO:0030018,GO:0031674,GO:0032501,GO:0032502,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0048513,GO:0048731,GO:0048856,GO:0050808,GO:0061061,GO:0071840,GO:0099080,GO:0099081,GO:0099512	-	-	-	-	-	-	-	-	-	-	Transglut_core
WZS1_k127_7524637_1	404380.Gbem_2348	1.374e-55	197.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
WZS1_k127_7528030_1	665571.STHERM_c07130	3.535e-205	649.0	COG0540@1|root,COG1781@1|root,COG0540@2|Bacteria,COG1781@2|Bacteria,2J5J0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Aspartate ornithine carbamoyltransferase, carbamoyl-P binding	pyrB	-	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI,PyrI_C
WZS1_k127_7528030_0	665571.STHERM_c07150	5.945e-268	850.0	COG5009@1|root,COG5009@2|Bacteria,2J5D4@203691|Spirochaetes	203691|Spirochaetes	M	penicillin-binding protein	pbp-3	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
WZS1_k127_7528030_2	573413.Spirs_1729	7.397e-21	102.0	2C3NH@1|root,34BGE@2|Bacteria,2J6JZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
WZS1_k127_7535322_4	545694.TREPR_1623	7.544e-96	333.0	COG1305@1|root,COG1305@2|Bacteria,2J57S@203691|Spirochaetes	203691|Spirochaetes	E	IPT TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
WZS1_k127_7535322_0	573413.Spirs_2149	1.491e-189	599.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
WZS1_k127_7535322_3	123214.PERMA_1233	2.709e-99	335.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	hprA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
WZS1_k127_7535322_6	645512.GCWU000246_00101	6.968e-82	275.0	COG0450@1|root,COG0450@2|Bacteria,3TB27@508458|Synergistetes	508458|Synergistetes	O	Alkyl hydroperoxide reductase	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
WZS1_k127_7535322_12	1089550.ATTH01000001_gene1272	9.006e-25	112.0	COG2802@1|root,COG2802@2|Bacteria,4NEJU@976|Bacteroidetes,1FJ9M@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
WZS1_k127_7535322_1	998088.B565_0009	7.007e-137	447.0	COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria,1Y41U@135624|Aeromonadales	135624|Aeromonadales	E	Aminotransferase class I and II	avtA	-	2.6.1.66	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130	-	R01215	RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_7535322_8	1353529.M899_3479	3.712e-50	183.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2MT3K@213481|Bdellovibrionales,2WPHH@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
WZS1_k127_7535322_13	906968.Trebr_2261	2.463e-24	108.0	COG0071@1|root,COG0071@2|Bacteria,2J88K@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K06335,ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
WZS1_k127_7535322_5	1480694.DC28_06395	2.694e-86	296.0	COG0042@1|root,COG0042@2|Bacteria,2J59K@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
WZS1_k127_7535322_11	1294142.CINTURNW_4259	1.363e-38	148.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,24NZG@186801|Clostridia,36VU4@31979|Clostridiaceae	186801|Clostridia	P	Ferric uptake regulator family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
WZS1_k127_7535322_7	614083.AWQR01000035_gene3617	3.877e-67	240.0	COG2267@1|root,COG2267@2|Bacteria,1QVW4@1224|Proteobacteria	1224|Proteobacteria	I	hydrolases or acyltransferases, alpha beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Esterase,Hydrolase_4
WZS1_k127_7535322_2	665571.STHERM_c21360	1.711e-99	342.0	COG5001@1|root,COG5001@2|Bacteria,2J5Z5@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
WZS1_k127_7535322_9	697303.Thewi_1663	3.315e-46	184.0	COG2199@1|root,COG3706@2|Bacteria,1UHZ8@1239|Firmicutes,25E7W@186801|Clostridia,42FF0@68295|Thermoanaerobacterales	186801|Clostridia	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
WZS1_k127_7535322_14	744872.Spica_1611	1.476e-13	73.0	COG0268@1|root,COG0268@2|Bacteria,2J84G@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
WZS1_k127_7535322_10	573413.Spirs_3185	1.69e-39	149.0	COG0776@1|root,COG0776@2|Bacteria,2J7PW@203691|Spirochaetes	203691|Spirochaetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K04764,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
WZS1_k127_7540152_1	720555.BATR1942_06400	5.575e-05	51.0	COG0300@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,4HV19@91061|Bacilli,1ZD1S@1386|Bacillus	91061|Bacilli	Q	Polyketide synthase of type I	-	-	-	ko:K13612,ko:K13613,ko:K13615	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_7540152_0	1291050.JAGE01000002_gene3678	3.55e-255	825.0	COG3321@1|root,COG4221@1|root,COG3321@2|Bacteria,COG4221@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
WZS1_k127_7542353_0	665571.STHERM_c06090	6.12e-129	424.0	COG2211@1|root,COG2211@2|Bacteria,2JA62@203691|Spirochaetes	203691|Spirochaetes	G	Vacuole effluxer Atg22 like	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
WZS1_k127_7546072_0	665571.STHERM_c01540	9.271e-170	582.0	COG3420@1|root,COG4733@1|root,COG3420@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	5.1.3.37	ko:K01795,ko:K20276	ko00051,ko02024,map00051,map02024	-	R08693	RC00509	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Big_2,F5_F8_type_C,SLH,TIR_2
WZS1_k127_7554621_7	296591.Bpro_0886	5.871e-25	106.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,4AAD1@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
WZS1_k127_7554621_1	292459.STH2587	3.462e-71	258.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
WZS1_k127_7554621_6	1410609.JHVB01000002_gene1357	2.04e-25	118.0	2AMK0@1|root,31CFX@2|Bacteria,2J732@203691|Spirochaetes	203691|Spirochaetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
WZS1_k127_7554621_0	573413.Spirs_2383	1.952e-243	768.0	COG0210@1|root,COG0210@2|Bacteria,2J5T4@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
WZS1_k127_7554621_8	679201.HMPREF9334_02015	1.565e-12	78.0	COG0614@1|root,COG0614@2|Bacteria,1TS94@1239|Firmicutes,4H2EC@909932|Negativicutes	909932|Negativicutes	P	Periplasmic binding protein	hmuT2	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
WZS1_k127_7554621_4	889378.Spiaf_2247	1.521e-48	189.0	COG0609@1|root,COG0609@2|Bacteria,2J6D8@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
WZS1_k127_7554621_5	1223542.GM1_012_01280	1.626e-31	133.0	COG1120@1|root,COG1120@2|Bacteria,2I3B3@201174|Actinobacteria,4GB7C@85026|Gordoniaceae	201174|Actinobacteria	HP	ATPases associated with a variety of cellular activities	hmuV	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
WZS1_k127_7554621_3	521010.BbiDN127_0190	9.74e-49	184.0	COG0084@1|root,COG0084@2|Bacteria,2J8FE@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
WZS1_k127_7554621_2	1480694.DC28_08745	4.254e-54	199.0	COG2885@1|root,COG2885@2|Bacteria,2J74V@203691|Spirochaetes	203691|Spirochaetes	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
WZS1_k127_7556319_0	665571.STHERM_c09890	1.838e-17	85.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
WZS1_k127_7556319_1	1226325.HMPREF1548_05533	4.701e-06	61.0	COG0457@1|root,COG1645@1|root,COG0457@2|Bacteria,COG1645@2|Bacteria,1UZ4D@1239|Firmicutes,24FD8@186801|Clostridia,36VMC@31979|Clostridiaceae	186801|Clostridia	S	Fn3 associated	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Fn3_assoc,TPR_19,zinc_ribbon_2
WZS1_k127_7559004_1	1434929.X946_5430	1.315e-05	51.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,2VV8F@28216|Betaproteobacteria,1KABY@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
WZS1_k127_7559004_0	1480694.DC28_03360	4.626e-77	277.0	COG1315@1|root,COG1315@2|Bacteria,2J6E5@203691|Spirochaetes	203691|Spirochaetes	L	Pfam:DUF342	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
WZS1_k127_7561650_0	1480694.DC28_07140	2.38e-243	762.0	COG0488@1|root,COG0488@2|Bacteria,2J5P1@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
WZS1_k127_7561650_2	1307761.L21SP2_1728	5.294e-23	108.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
WZS1_k127_7561650_1	889378.Spiaf_2835	1.482e-59	220.0	COG5360@1|root,COG5360@2|Bacteria,2J6PR@203691|Spirochaetes	203691|Spirochaetes	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7566531_1	1123274.KB899431_gene3266	1.043e-199	665.0	COG1196@1|root,COG1196@2|Bacteria,2J5RV@203691|Spirochaetes	203691|Spirochaetes	D	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,HTH_38
WZS1_k127_7566531_5	573413.Spirs_3199	3.186e-47	176.0	COG0576@1|root,COG0576@2|Bacteria,2J7UP@203691|Spirochaetes	203691|Spirochaetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
WZS1_k127_7566531_0	1123274.KB899431_gene3268	7.696e-307	951.0	COG0443@1|root,COG0443@2|Bacteria,2J5I0@203691|Spirochaetes	203691|Spirochaetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
WZS1_k127_7566531_2	906968.Trebr_1496	2.101e-139	452.0	COG0484@1|root,COG0484@2|Bacteria,2J614@203691|Spirochaetes	203691|Spirochaetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
WZS1_k127_7566531_4	760011.Spico_1676	1.238e-67	237.0	COG0566@1|root,COG0566@2|Bacteria,2J748@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
WZS1_k127_7566531_3	1307761.L21SP2_1360	7.627e-120	398.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	purD	-	6.3.4.13,6.3.5.3	ko:K01945,ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04463	RC00010,RC00090,RC00166,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
WZS1_k127_7566531_6	1307761.L21SP2_1361	5.155e-45	169.0	COG0299@1|root,COG0299@2|Bacteria	2|Bacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
WZS1_k127_7566531_7	194439.CT0094	1.778e-26	112.0	COG0150@1|root,COG0150@2|Bacteria,1FDK2@1090|Chlorobi	1090|Chlorobi	F	AIR synthase related protein domain protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
WZS1_k127_7567564_0	378806.STAUR_2485	7.004e-34	148.0	COG5635@1|root,COG5635@2|Bacteria,1N30Y@1224|Proteobacteria,42XW0@68525|delta/epsilon subdivisions,2WT9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7567564_1	658086.HMPREF0994_05687	1.406e-07	57.0	COG1396@1|root,COG1396@2|Bacteria,1VEPX@1239|Firmicutes,24R13@186801|Clostridia,27QBW@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
WZS1_k127_7572718_6	1094508.Tsac_0978	0.0001548	46.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,24JE8@186801|Clostridia,42G0X@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
WZS1_k127_7572718_4	1304880.JAGB01000003_gene1317	9.119e-53	201.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,247SS@186801|Clostridia	186801|Clostridia	H	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
WZS1_k127_7572718_0	906968.Trebr_0998	4.315e-283	892.0	COG0542@1|root,COG0542@2|Bacteria,2J5B9@203691|Spirochaetes	203691|Spirochaetes	O	ATPase family associated with various cellular activities (AAA)	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
WZS1_k127_7572718_5	1313301.AUGC01000003_gene1936	1.467e-10	75.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes	976|Bacteroidetes	G	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
WZS1_k127_7572718_3	744872.Spica_0778	9.927e-65	228.0	COG0503@1|root,COG0503@2|Bacteria,2J7CM@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
WZS1_k127_7572718_2	1480694.DC28_01275	6.816e-143	463.0	COG0505@1|root,COG0505@2|Bacteria,2J5HK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
WZS1_k127_7572718_1	158190.SpiGrapes_2040	3.702e-267	833.0	COG0458@1|root,COG0458@2|Bacteria,2J6A8@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
WZS1_k127_7585626_3	498761.HM1_1861	1.167e-66	239.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia	186801|Clostridia	L	PFAM DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
WZS1_k127_7585626_2	56780.SYN_03005	2.645e-71	247.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,42R47@68525|delta/epsilon subdivisions,2WNUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Membrane protein, UPF0126 and UPF0126 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
WZS1_k127_7585626_0	573413.Spirs_1894	0.0	1468.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
WZS1_k127_7585626_4	573413.Spirs_1896	2.936e-56	203.0	COG0118@1|root,COG0118@2|Bacteria,2J8MS@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
WZS1_k127_7585626_1	1480694.DC28_14810	4.635e-120	391.0	COG0107@1|root,COG0107@2|Bacteria,2J6FB@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
WZS1_k127_7585626_6	889378.Spiaf_2473	3.683e-20	94.0	COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes	203691|Spirochaetes	S	FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
WZS1_k127_7585626_5	1123274.KB899415_gene2510	3.093e-32	128.0	COG0640@1|root,COG0640@2|Bacteria,2J8H9@203691|Spirochaetes	203691|Spirochaetes	K	arsR family	-	-	-	ko:K22298	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
WZS1_k127_75917_3	1321815.HMPREF9193_00334	4.616e-22	99.0	COG1385@1|root,COG1385@2|Bacteria,2J81V@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
WZS1_k127_75917_1	1499967.BAYZ01000028_gene1277	2.283e-24	105.0	COG1534@1|root,COG1534@2|Bacteria	2|Bacteria	J	preribosome binding	yhbY	GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
WZS1_k127_75917_2	573413.Spirs_0877	1.323e-22	109.0	COG1105@1|root,COG1105@2|Bacteria,2J7B3@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.144,2.7.1.56	ko:K00882,ko:K00917	ko00051,ko00052,ko01100,map00051,map00052,map01100	-	R02071,R03236	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
WZS1_k127_75917_0	243275.TDE_2699	1.51e-61	231.0	COG4372@1|root,COG4372@2|Bacteria,2J5RI@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Borrelia P83 100 protein	-	-	-	-	-	-	-	-	-	-	-	-	Borrelia_P83
WZS1_k127_7594255_2	1179778.PMM47T1_28662	6.894e-06	55.0	COG1476@1|root,COG1476@2|Bacteria,1REIS@1224|Proteobacteria,1S4D2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
WZS1_k127_7594255_1	877455.Metbo_1452	5.27e-37	143.0	COG5646@1|root,arCOG09457@2157|Archaea	2157|Archaea	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
WZS1_k127_7594255_0	1121405.dsmv_2296	1.734e-127	413.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,43C0D@68525|delta/epsilon subdivisions,2WIYN@28221|Deltaproteobacteria,2MHY4@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10
WZS1_k127_7602536_1	396588.Tgr7_3082	4.547e-61	215.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQPA@1236|Gammaproteobacteria,1X2CQ@135613|Chromatiales	135613|Chromatiales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
WZS1_k127_7602536_0	620914.JH621304_gene10	1.591e-128	419.0	COG0715@1|root,COG0715@2|Bacteria,4NM1E@976|Bacteroidetes,1IAUW@117743|Flavobacteriia,2YK6M@290174|Aquimarina	976|Bacteroidetes	MP	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2,OmpA
WZS1_k127_7621932_0	754027.HMPREF9554_01551	1.549e-53	197.0	COG1187@1|root,COG1187@2|Bacteria,2J5AJ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
WZS1_k127_7621932_1	158190.SpiGrapes_0427	5.207e-49	184.0	COG0283@1|root,COG0283@2|Bacteria,2J74Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
WZS1_k127_7621932_2	545695.TREAZ_0507	4.892e-16	80.0	COG0539@1|root,COG0539@2|Bacteria,2J5DZ@203691|Spirochaetes	203691|Spirochaetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Cytidylate_kin,S1
WZS1_k127_762374_5	469606.FSCG_00756	1.519e-13	71.0	COG0130@1|root,COG0130@2|Bacteria,378NK@32066|Fusobacteria	32066|Fusobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
WZS1_k127_762374_3	665571.STHERM_c11170	3.392e-27	114.0	COG0858@1|root,COG0858@2|Bacteria,2J82W@203691|Spirochaetes	203691|Spirochaetes	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
WZS1_k127_762374_0	573413.Spirs_2028	2.322e-277	877.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
WZS1_k127_762374_2	1123274.KB899421_gene1756	6.441e-190	604.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
WZS1_k127_762374_4	754027.HMPREF9554_02448	9.365e-19	91.0	COG0779@1|root,COG0779@2|Bacteria,2J87E@203691|Spirochaetes	203691|Spirochaetes	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
WZS1_k127_762374_6	667014.Thein_1024	5.803e-10	68.0	COG1040@1|root,COG1040@2|Bacteria,2GH0G@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
WZS1_k127_762374_1	639282.DEFDS_2173	8.692e-196	640.0	COG0249@1|root,COG0249@2|Bacteria,2GEK4@200930|Deferribacteres	200930|Deferribacteres	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
WZS1_k127_7629182_0	545695.TREAZ_1844	1.313e-34	137.0	COG2318@1|root,COG2318@2|Bacteria,2J94Z@203691|Spirochaetes	203691|Spirochaetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
WZS1_k127_7629543_1	1123274.KB899415_gene2499	2.16e-67	245.0	COG0617@1|root,COG1418@1|root,COG0617@2|Bacteria,COG1418@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
WZS1_k127_7629543_0	573413.Spirs_1889	3.378e-97	323.0	COG0571@1|root,COG0571@2|Bacteria,2J6UI@203691|Spirochaetes	203691|Spirochaetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
WZS1_k127_7629543_2	1307761.L21SP2_1752	1.768e-24	104.0	COG0236@1|root,COG0236@2|Bacteria,2J8CN@203691|Spirochaetes	203691|Spirochaetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
WZS1_k127_7629543_3	744872.Spica_1406	3.24e-21	94.0	COG0333@1|root,COG0333@2|Bacteria,2J8XR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
WZS1_k127_7629543_4	243275.TDE_1375	2.499e-07	53.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
WZS1_k127_7646234_1	864565.HMPREF0379_1738	2.812e-36	142.0	COG0783@1|root,COG0783@2|Bacteria,1VCVJ@1239|Firmicutes,25CW6@186801|Clostridia	186801|Clostridia	P	Belongs to the Dps family	dps	-	-	-	-	-	-	-	-	-	-	-	Ferritin
WZS1_k127_7646234_3	158190.SpiGrapes_2307	6.537e-06	52.0	29AXJ@1|root,2ZXWN@2|Bacteria,2JBAS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_7646234_0	1123274.KB899432_gene2919	8.454e-88	305.0	COG0475@1|root,COG0475@2|Bacteria,2J5WC@203691|Spirochaetes	203691|Spirochaetes	P	Sodium hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger
WZS1_k127_7646234_2	665571.STHERM_c03740	2.101e-17	88.0	COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes	203691|Spirochaetes	G	DNA-binding protein PTS system, IIA component	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
WZS1_k127_7650818_0	573413.Spirs_1796	3.079e-89	299.0	COG0533@1|root,COG0533@2|Bacteria,2J5WG@203691|Spirochaetes	203691|Spirochaetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
WZS1_k127_7650818_2	1307761.L21SP2_1420	2.024e-59	216.0	COG2861@1|root,COG2861@2|Bacteria,2J75Z@203691|Spirochaetes	203691|Spirochaetes	S	Divergent polysaccharide deacetylase	-	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
WZS1_k127_7650818_1	744872.Spica_0849	1.149e-87	299.0	COG0568@1|root,COG0568@2|Bacteria,2J7R0@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
WZS1_k127_7650818_3	1289135.A966_07934	1.559e-18	88.0	COG3951@1|root,COG3951@2|Bacteria	2|Bacteria	MNO	Flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02035	-	GH23	-	Rod-binding
WZS1_k127_7658802_0	573413.Spirs_1790	4.559e-137	439.0	COG4786@1|root,COG4786@2|Bacteria,2J57D@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein FlgG	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
WZS1_k127_7658802_1	573413.Spirs_1789	9.085e-119	389.0	COG4786@1|root,COG4786@2|Bacteria,2J5EJ@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein	flhO	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
WZS1_k127_766768_0	1167006.UWK_00694	5.483e-79	277.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
WZS1_k127_7682146_1	665571.STHERM_c07820	2.99e-64	226.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	metW	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	MetW
WZS1_k127_7682146_0	744872.Spica_1697	1.16e-66	233.0	COG0290@1|root,COG0290@2|Bacteria,2J76T@203691|Spirochaetes	203691|Spirochaetes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
WZS1_k127_7682146_3	545695.TREAZ_0920	5.409e-23	101.0	COG0291@1|root,COG0291@2|Bacteria,2J8RR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
WZS1_k127_7682146_2	665571.STHERM_c07790	3.41e-45	166.0	COG0292@1|root,COG0292@2|Bacteria,2J82V@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
WZS1_k127_7682146_4	1307761.L21SP2_1247	3.983e-16	85.0	28ZFQ@1|root,2ZM78@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ZapB
WZS1_k127_7689731_0	665571.STHERM_c01730	2.164e-44	186.0	COG5184@1|root,COG5184@2|Bacteria,2J9P6@203691|Spirochaetes	203691|Spirochaetes	DZ	regulator of chromosome condensation, RCC1	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
WZS1_k127_785197_2	573413.Spirs_1873	6.428e-26	108.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
WZS1_k127_785197_1	1307761.L21SP2_1740	3.271e-29	118.0	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
WZS1_k127_785197_0	1480694.DC28_01875	4.05e-108	355.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
WZS1_k127_788608_0	1480694.DC28_00390	1.008e-93	314.0	COG1702@1|root,COG1702@2|Bacteria,2J64H@203691|Spirochaetes	203691|Spirochaetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
WZS1_k127_788608_2	1307761.L21SP2_1873	6.746e-30	124.0	COG0319@1|root,COG0319@2|Bacteria,2J7YN@203691|Spirochaetes	203691|Spirochaetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
WZS1_k127_788608_1	744872.Spica_1230	8.797e-85	286.0	COG1253@1|root,COG1253@2|Bacteria,2J61P@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1253 Hemolysins and related protein containing CBS domains	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
WZS1_k127_792640_1	545695.TREAZ_1383	4.472e-15	77.0	COG1694@1|root,COG3956@2|Bacteria,2J5HG@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM MazG family protein	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
WZS1_k127_792640_0	926562.Oweho_0271	1.86e-53	195.0	2CA4G@1|root,2Z87D@2|Bacteria,4NFIG@976|Bacteroidetes,1I0Z0@117743|Flavobacteriia,2PBI3@246874|Cryomorphaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_799163_3	522772.Dacet_0548	1.888e-51	187.0	COG3328@1|root,COG3328@2|Bacteria,2GGBW@200930|Deferribacteres	2|Bacteria	L	PFAM transposase mutator type	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
WZS1_k127_799163_7	888059.HMPREF9071_1868	7.459e-06	53.0	2ETCB@1|root,33KW7@2|Bacteria,4NY4M@976|Bacteroidetes,1I6FZ@117743|Flavobacteriia,1ES7Q@1016|Capnocytophaga	976|Bacteroidetes	S	Domain of unknown function (DUF4878)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4878
WZS1_k127_799163_0	744872.Spica_0491	4.624e-136	441.0	COG0240@1|root,COG0240@2|Bacteria,2J68Z@203691|Spirochaetes	203691|Spirochaetes	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
WZS1_k127_799163_1	1123024.AUII01000021_gene69	9.748e-95	327.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
WZS1_k127_799163_2	1158338.JNLJ01000001_gene338	1.684e-62	233.0	COG2204@1|root,COG2204@2|Bacteria,2G3R2@200783|Aquificae	200783|Aquificae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
WZS1_k127_799163_5	1173029.JH980292_gene3729	1.424e-34	140.0	COG0797@1|root,COG0797@2|Bacteria,1G0XF@1117|Cyanobacteria,1H985@1150|Oscillatoriales	1117|Cyanobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
WZS1_k127_799163_4	1121459.AQXE01000003_gene1144	6.967e-49	196.0	COG0834@1|root,COG3852@1|root,COG0834@2|Bacteria,COG3852@2|Bacteria,1N315@1224|Proteobacteria,43CSY@68525|delta/epsilon subdivisions,2X80H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg,SBP_bac_3
WZS1_k127_799163_6	1122994.AUFR01000001_gene1396	1.431e-18	91.0	COG0507@1|root,COG0507@2|Bacteria,2GIX1@201174|Actinobacteria,4DPY9@85009|Propionibacteriales	201174|Actinobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
WZS1_k127_80745_0	401526.TcarDRAFT_1001	2.478e-73	254.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,4H3E9@909932|Negativicutes	909932|Negativicutes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
WZS1_k127_80745_1	743966.MYB_01665	5.392e-23	99.0	COG0185@1|root,COG0185@2|Bacteria,3WTPD@544448|Tenericutes	544448|Tenericutes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
WZS1_k127_810761_0	744872.Spica_1001	3.083e-25	115.0	2BFD2@1|root,3296F@2|Bacteria,2JB82@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_834491_0	1123057.P872_12930	0.0	3140.0	COG3459@1|root,COG3459@2|Bacteria,4NIVN@976|Bacteroidetes,47MEX@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
WZS1_k127_834491_1	744872.Spica_1006	2.213e-81	299.0	2C0A1@1|root,33WBM@2|Bacteria,2J8WC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_840487_2	1122201.AUAZ01000001_gene2416	2.024e-74	260.0	COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,1RP83@1236|Gammaproteobacteria,465UG@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
WZS1_k127_840487_0	335541.Swol_1730	2.017e-166	566.0	COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,42KPE@68298|Syntrophomonadaceae	186801|Clostridia	L	Putative exonuclease SbcCD, C subunit	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_29,SbcCD_C
WZS1_k127_840487_5	1123400.KB904749_gene754	1.18e-46	176.0	COG3619@1|root,COG3619@2|Bacteria,1RB5Q@1224|Proteobacteria,1RRG5@1236|Gammaproteobacteria,4619N@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF1275)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1275
WZS1_k127_840487_1	197221.22295588	1.538e-93	321.0	COG3146@1|root,COG3146@2|Bacteria,1G0U8@1117|Cyanobacteria	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
WZS1_k127_840487_4	1232437.KL661988_gene88	4.379e-47	182.0	COG0042@1|root,COG0042@2|Bacteria,1QDJE@1224|Proteobacteria,42PCR@68525|delta/epsilon subdivisions,2WKBH@28221|Deltaproteobacteria,2MJ5C@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
WZS1_k127_840487_3	1480694.DC28_05045	2.771e-61	214.0	COG0436@1|root,COG0436@2|Bacteria,2J6H6@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
WZS1_k127_860555_1	889378.Spiaf_1515	9.925e-43	161.0	COG0539@1|root,COG0539@2|Bacteria,2J5DZ@203691|Spirochaetes	203691|Spirochaetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Cytidylate_kin,S1
WZS1_k127_860555_0	573413.Spirs_2057	2.085e-164	531.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,2J63K@203691|Spirochaetes	203691|Spirochaetes	KT	Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
WZS1_k127_860555_3	1123274.KB899421_gene1788	1.429e-08	64.0	COG1729@1|root,COG1729@2|Bacteria,2J7YF@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_6,TPR_8
WZS1_k127_860555_2	1123274.KB899421_gene1789	2.898e-34	138.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
WZS1_k127_869630_0	243275.TDE_0817	4.744e-60	211.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR5	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,DUF1376,HATPase_c_4,HTH_11,HTH_24,HTH_5
WZS1_k127_869630_1	357809.Cphy_1473	1.507e-56	211.0	COG0627@1|root,COG0627@2|Bacteria,1VJ65@1239|Firmicutes	1239|Firmicutes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
WZS1_k127_87583_0	1480694.DC28_02620	8.674e-37	144.0	COG1345@1|root,COG1345@2|Bacteria,2J6CW@203691|Spirochaetes	203691|Spirochaetes	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
WZS1_k127_87583_3	665571.STHERM_c07700	5.718e-23	108.0	2DF69@1|root,2ZQMH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_87583_4	314723.BH0187	1.243e-12	70.0	2C5AY@1|root,2ZWTW@2|Bacteria,2J9G2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_87583_1	349520.PPE_01177	2.799e-31	129.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,4HIIF@91061|Bacilli,26XDA@186822|Paenibacillaceae	91061|Bacilli	S	ATP-binding protein	ydiB	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
WZS1_k127_87583_2	573413.Spirs_2605	3.002e-27	118.0	COG1214@1|root,COG1214@2|Bacteria,2J80U@203691|Spirochaetes	203691|Spirochaetes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
WZS1_k127_882225_2	1480694.DC28_10295	6.24e-52	199.0	COG0840@1|root,COG0840@2|Bacteria,2J81D@203691|Spirochaetes	203691|Spirochaetes	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_882225_3	889378.Spiaf_2425	1.908e-47	173.0	COG0745@1|root,COG0745@2|Bacteria,2J89I@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	cheY-2	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
WZS1_k127_882225_0	269799.Gmet_2418	8.897e-148	475.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,43S6W@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
WZS1_k127_882225_1	118005.AWNK01000005_gene1447	1.159e-62	225.0	COG1352@1|root,COG1352@2|Bacteria	2|Bacteria	NT	protein-glutamate O-methyltransferase activity	cheR2	-	2.1.1.80,3.1.1.61,3.5.1.44	ko:K00575,ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheR,CheR_N
WZS1_k127_882225_5	1232410.KI421418_gene2131	8.74e-41	156.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,43UNN@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
WZS1_k127_882225_4	1156935.QWE_00535	1.643e-44	168.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,4B8FN@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
WZS1_k127_882908_0	889378.Spiaf_2666	3.594e-117	393.0	COG5000@1|root,COG5000@2|Bacteria,2J753@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
WZS1_k127_89614_2	338966.Ppro_0321	3.4e-13	73.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,43SUV@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
WZS1_k127_89614_1	97138.C820_01123	1.551e-44	186.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,36F39@31979|Clostridiaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
WZS1_k127_896427_0	498211.CJA_0457	2.444e-24	112.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1FHR7@10|Cellvibrio	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PKD,Peptidase_S8
WZS1_k127_896427_1	445987.BVAVS116_0141	2.458e-10	66.0	COG1538@1|root,COG1538@2|Bacteria,2J5YA@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
WZS1_k127_903843_1	221027.JO40_08835	5.507e-36	141.0	COG1671@1|root,COG1671@2|Bacteria,2J84V@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
WZS1_k127_903843_0	744872.Spica_0660	4.83e-64	222.0	COG0205@1|root,COG0205@2|Bacteria,2J60A@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
WZS1_k127_921104_4	573413.Spirs_2048	2.178e-29	127.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cohesin,DUF11,SLH
WZS1_k127_921104_2	889378.Spiaf_1524	1.545e-54	205.0	COG0457@1|root,COG0457@2|Bacteria,2J5D0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_2
WZS1_k127_921104_0	744872.Spica_1373	3.967e-170	542.0	COG0468@1|root,COG0468@2|Bacteria,2J5G5@203691|Spirochaetes	203691|Spirochaetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
WZS1_k127_921104_3	1111069.TCCBUS3UF1_19630	1.543e-29	125.0	COG0801@1|root,COG0801@2|Bacteria,1WJU9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
WZS1_k127_921104_1	889378.Spiaf_1519	4.834e-81	274.0	COG1354@1|root,COG1354@2|Bacteria,2J5RF@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
WZS1_k127_937521_1	329726.AM1_4149	2.966e-101	336.0	COG0692@1|root,COG0692@2|Bacteria,1G5YY@1117|Cyanobacteria	1117|Cyanobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
WZS1_k127_937521_3	661478.OP10G_1817	5.342e-28	116.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2
WZS1_k127_937521_0	545695.TREAZ_0021	8.4e-167	543.0	COG0747@1|root,COG0747@2|Bacteria,2J5H2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
WZS1_k127_937521_2	869209.Tresu_0138	8.768e-76	261.0	COG0601@1|root,COG0601@2|Bacteria,2J6BK@203691|Spirochaetes	203691|Spirochaetes	EP	Permease protein	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
WZS1_k127_940994_0	1168034.FH5T_17120	2.263e-40	157.0	2CM5E@1|root,332ZW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_940994_1	1121091.AUMP01000034_gene1518	1.215e-05	53.0	2EH6I@1|root,33AYE@2|Bacteria,1VP74@1239|Firmicutes,4HSH5@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
WZS1_k127_943295_0	889378.Spiaf_2847	2.103e-60	214.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,RDD,Yop-YscD_cpl
WZS1_k127_943295_1	889378.Spiaf_2846	6.249e-38	157.0	COG0515@1|root,COG0515@2|Bacteria,2J6N6@203691|Spirochaetes	203691|Spirochaetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
WZS1_k127_952639_2	604354.TSIB_0947	1.015e-40	160.0	COG1192@1|root,arCOG00586@2157|Archaea,2XV5C@28890|Euryarchaeota,2435W@183968|Thermococci	28890|Euryarchaeota	D	Cellulose biosynthesis protein BcsQ	minD	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
WZS1_k127_952639_0	634499.EpC_31770	5.337e-59	226.0	COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA primase	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_2,Toprim_N,zf-CHC2
WZS1_k127_952639_3	1121430.JMLG01000003_gene533	2.058e-26	121.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,260PK@186807|Peptococcaceae	186801|Clostridia	D	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WZS1_k127_952639_1	1288826.MSNKSG1_01203	4.761e-41	166.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,464UI@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	COG4974 Site-specific recombinase XerD	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
WZS1_k127_972075_0	665571.STHERM_c19120	1.195e-150	485.0	COG1744@1|root,COG1744@2|Bacteria,2J7UH@203691|Spirochaetes	203691|Spirochaetes	S	Membrane protein, bmp family	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
WZS1_k127_972075_1	177437.HRM2_06320	4.755e-109	362.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2MIER@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
## 3359 queries scanned
## Total time (seconds): 248.4013261795044
## Rate: 13.52 q/s