## Fri Feb 20 02:27:08 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/XH1_bin.43.fa -m mmseqs --output XH1_bin.43 --output_dir /data/result/bins/wyx/eggqs50+/XH1_bin.43 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
XH1_k127_1040605_0	439235.Dalk_3434	1.126e-184	588.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
XH1_k127_1040605_1	1123277.KB893183_gene94	1.6e-09	64.0	arCOG06174@1|root,33GGV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_104224_1	1232410.KI421424_gene1615	7.004e-71	250.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WK9P@28221|Deltaproteobacteria,43TJ8@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
XH1_k127_104224_3	889378.Spiaf_2232	8.188e-15	78.0	291RI@1|root,2ZPBI@2|Bacteria,2J8IP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_104224_0	522772.Dacet_2325	4.597e-158	508.0	COG0112@1|root,COG0112@2|Bacteria,2GERI@200930|Deferribacteres	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
XH1_k127_104224_2	1201290.M902_0847	5.17e-25	116.0	COG0628@1|root,COG0628@2|Bacteria,1PMAP@1224|Proteobacteria,4345I@68525|delta/epsilon subdivisions,2MTCT@213481|Bdellovibrionales,2X23B@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
XH1_k127_1059776_7	1238184.CM001792_gene2160	0.0005094	51.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,23IZA@182709|Oceanobacillus	91061|Bacilli	NT	Cache domain	mcpA3	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
XH1_k127_1059776_1	203119.Cthe_3158	1.212e-259	814.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,3WG9R@541000|Ruminococcaceae	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
XH1_k127_1059776_4	913865.DOT_0632	3.995e-27	117.0	2DNPN@1|root,32YG3@2|Bacteria,1W09D@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867
XH1_k127_1059776_5	1242864.D187_003787	2.886e-09	62.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	4.6.1.1	ko:K01768,ko:K21397	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	DUF3662,FHA,Yop-YscD_cpl
XH1_k127_1059776_3	56780.SYN_02377	1.197e-37	145.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MS9E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
XH1_k127_1059776_0	720554.Clocl_3023	6.421e-297	928.0	COG0542@1|root,COG0542@2|Bacteria,1UJ1Z@1239|Firmicutes,24AIQ@186801|Clostridia,3WHBF@541000|Ruminococcaceae	186801|Clostridia	O	C-terminal, D2-small domain, of ClpB protein	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
XH1_k127_1059776_2	1307759.JOMJ01000003_gene2091	4.186e-73	254.0	COG1192@1|root,COG1192@2|Bacteria,1Q9Y4@1224|Proteobacteria,42ZVG@68525|delta/epsilon subdivisions,2WV5I@28221|Deltaproteobacteria,2MFX2@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
XH1_k127_1059776_6	483219.LILAB_29425	1.207e-08	66.0	COG4254@1|root,COG4254@2|Bacteria,1PYGE@1224|Proteobacteria,435C1@68525|delta/epsilon subdivisions,2WZPJ@28221|Deltaproteobacteria,2Z2H5@29|Myxococcales	28221|Deltaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
XH1_k127_1065178_2	1121403.AUCV01000014_gene4643	4.151e-14	75.0	COG0236@1|root,COG0236@2|Bacteria,1PBR6@1224|Proteobacteria,43361@68525|delta/epsilon subdivisions,2WY5N@28221|Deltaproteobacteria,2MP4R@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
XH1_k127_1065178_0	1121403.AUCV01000014_gene4642	1.765e-167	535.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42PFM@68525|delta/epsilon subdivisions,2WJVK@28221|Deltaproteobacteria,2MJ4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
XH1_k127_1065178_1	879212.DespoDRAFT_01397	5.287e-35	139.0	COG0204@1|root,COG0204@2|Bacteria,1REJD@1224|Proteobacteria,42RHJ@68525|delta/epsilon subdivisions,2WNBM@28221|Deltaproteobacteria,2MNA2@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
XH1_k127_1067250_0	56107.Cylst_4663	3.123e-41	160.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4251@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4251@2|Bacteria,1GQ9E@1117|Cyanobacteria,1HIP0@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,Pkinase
XH1_k127_1091247_1	717231.Flexsi_1272	2.089e-53	198.0	COG0061@1|root,COG0061@2|Bacteria,2GEK1@200930|Deferribacteres	200930|Deferribacteres	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
XH1_k127_1091247_0	555079.Toce_1302	2.545e-124	418.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,42EZU@68295|Thermoanaerobacterales	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
XH1_k127_1163134_0	1196095.GAPWK_2728	8.991e-46	176.0	COG1876@1|root,COG1876@2|Bacteria,1N2IC@1224|Proteobacteria,1S0DU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	vanY	-	-	-	-	-	-	-	-	-	-	-	VanY
XH1_k127_1163134_1	1045858.Bint_2683	9.324e-38	146.0	COG0307@1|root,COG0307@2|Bacteria,2J7MN@203691|Spirochaetes	203691|Spirochaetes	H	riboflavin synthase alpha	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
XH1_k127_1269535_0	706587.Desti_1510	0.0	1154.0	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG2070@1|root,COG2977@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG2070@2|Bacteria,COG2977@2|Bacteria,COG3321@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
XH1_k127_1269553_1	395493.BegalDRAFT_0036	6.561e-28	117.0	2CGNA@1|root,3301B@2|Bacteria,1N74P@1224|Proteobacteria,1SFKY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_1269553_2	1124780.ANNU01000005_gene2377	6.062e-17	83.0	29WP1@1|root,30I9X@2|Bacteria,4NXPZ@976|Bacteroidetes,47SR6@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
XH1_k127_1269553_0	161156.JQKW01000011_gene940	2.987e-58	211.0	COG0761@1|root,COG0761@2|Bacteria,2GH35@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
XH1_k127_1291875_2	273057.SSO2710	0.0007077	51.0	COG0457@1|root,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
XH1_k127_1291875_0	1123274.KB899421_gene1743	1.763e-80	275.0	COG0217@1|root,COG0217@2|Bacteria,2J634@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
XH1_k127_1291875_1	1148.1001371	2.521e-08	56.0	COG0817@1|root,COG0817@2|Bacteria,1G62E@1117|Cyanobacteria,1H60E@1142|Synechocystis	1117|Cyanobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
XH1_k127_1292570_0	886379.AEWI01000012_gene1079	2.5e-64	231.0	COG0524@1|root,COG0524@2|Bacteria,4NIHI@976|Bacteroidetes,2FPRJ@200643|Bacteroidia,3XIRP@558415|Marinilabiliaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
XH1_k127_1292570_1	768670.Calni_0774	7.513e-54	204.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2GF2A@200930|Deferribacteres	200930|Deferribacteres	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
XH1_k127_130106_0	1232437.KL661958_gene2898	1.207e-82	284.0	COG2159@1|root,COG2159@2|Bacteria,1QA25@1224|Proteobacteria,430IB@68525|delta/epsilon subdivisions,2WSMC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
XH1_k127_130106_1	1167006.UWK_03210	2.736e-55	202.0	COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MJJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
XH1_k127_1346083_3	403833.Pmob_1009	9.718e-17	83.0	COG0313@1|root,COG0313@2|Bacteria,2GCSR@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
XH1_k127_1346083_4	665571.STHERM_c01610	0.000123	48.0	2DFDU@1|root,2ZRHI@2|Bacteria,2J8SZ@203691|Spirochaetes	203691|Spirochaetes	S	factor, FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
XH1_k127_1346083_2	760568.Desku_0165	5.783e-31	136.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,263X9@186807|Peptococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	ko:K19954	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
XH1_k127_1346083_0	580331.Thit_0728	6.834e-77	265.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42FCC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
XH1_k127_1346083_1	237368.SCABRO_02662	1.725e-47	178.0	COG1641@1|root,COG1641@2|Bacteria,2IXMJ@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
XH1_k127_1359228_0	644282.Deba_1938	1.164e-175	561.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
XH1_k127_1359228_1	1230342.CTM_05625	6.231e-14	74.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,36KHG@31979|Clostridiaceae	186801|Clostridia	T	Belongs to the UPF0237 family	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
XH1_k127_138012_1	315730.BcerKBAB4_4228	1.093e-17	85.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,4HBEG@91061|Bacilli,1ZC7K@1386|Bacillus	91061|Bacilli	O	COG0826 Collagenase and related proteases	yrrO	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
XH1_k127_138012_0	667014.Thein_0157	1.443e-74	263.0	COG1559@1|root,COG1559@2|Bacteria,2GHNN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
XH1_k127_1384632_1	592026.GCWU0000282_003210	3.276e-76	268.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia	186801|Clostridia	M	synthase	neuB	-	2.5.1.101,2.5.1.56	ko:K01654,ko:K18430	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R10304	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
XH1_k127_1384632_2	401526.TcarDRAFT_1563	3.749e-10	62.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4H2AT@909932|Negativicutes	909932|Negativicutes	NU	Type II IV secretion system protein	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
XH1_k127_1384632_0	1125863.JAFN01000001_gene231	5.686e-119	390.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_2853	Aminotran_4
XH1_k127_139612_0	765869.BDW_06660	2.402e-149	495.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2MTIN@213481|Bdellovibrionales,2WJ8D@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
XH1_k127_1418825_0	373903.Hore_03290	3.554e-170	546.0	COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,3WAZ7@53433|Halanaerobiales	186801|Clostridia	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
XH1_k127_1418825_1	439235.Dalk_0307	1.328e-60	216.0	COG0045@1|root,COG0045@2|Bacteria,1REBV@1224|Proteobacteria,42S1F@68525|delta/epsilon subdivisions,2WNW1@28221|Deltaproteobacteria,2MJUN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5
XH1_k127_1418825_2	443143.GM18_2350	1.387e-48	184.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1R8QH@1224|Proteobacteria,42T02@68525|delta/epsilon subdivisions,2WPNU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	PFAM WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
XH1_k127_1433138_1	443143.GM18_2756	5.476e-49	180.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42QWB@68525|delta/epsilon subdivisions,2WN8D@28221|Deltaproteobacteria,43US4@69541|Desulfuromonadales	1224|Proteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00334,ko:K18330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
XH1_k127_1433138_0	443143.GM18_2757	1.22e-235	742.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,43SYY@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase 51 Kd subunit	-	-	1.12.1.3,1.6.5.3	ko:K00124,ko:K00335,ko:K18331	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
XH1_k127_1437222_2	398767.Glov_1372	6.231e-48	175.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
XH1_k127_1437222_1	311424.DhcVS_442	2.005e-51	184.0	COG0100@1|root,COG0100@2|Bacteria,2G6HG@200795|Chloroflexi,34DAY@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
XH1_k127_1437222_3	398512.JQKC01000042_gene4170	4.291e-46	169.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,3WJ08@541000|Ruminococcaceae	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
XH1_k127_1437222_5	204669.Acid345_1250	1.826e-11	65.0	COG0257@1|root,COG0257@2|Bacteria,3Y5X6@57723|Acidobacteria,2JK4W@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
XH1_k127_1437222_4	671143.DAMO_0562	1.518e-30	121.0	COG0361@1|root,COG0361@2|Bacteria,2NPNU@2323|unclassified Bacteria	2|Bacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
XH1_k127_1437222_0	1511.CLOST_2176	4.864e-87	294.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,25R17@186804|Peptostreptococcaceae	186801|Clostridia	E	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
XH1_k127_1471601_1	1123256.KB907927_gene1567	1.407e-06	53.0	COG0457@1|root,COG0457@2|Bacteria,1NB8N@1224|Proteobacteria,1SEZN@1236|Gammaproteobacteria,1X8HS@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_17,TPR_6
XH1_k127_1471601_0	1265313.HRUBRA_02860	3.187e-08	66.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1J736@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
XH1_k127_1472954_0	768670.Calni_0176	1.258e-63	229.0	COG1230@1|root,COG1230@2|Bacteria,2GGEC@200930|Deferribacteres	200930|Deferribacteres	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
XH1_k127_1503066_0	448385.sce4395	8.481e-20	104.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WPU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
XH1_k127_1503066_1	765420.OSCT_0409	1.052e-09	71.0	COG2234@1|root,COG2234@2|Bacteria,2G8I9@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
XH1_k127_1598100_1	909663.KI867150_gene322	1.157e-96	320.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MR71@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
XH1_k127_1598100_0	909663.KI867150_gene321	1.018e-191	603.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
XH1_k127_1602444_1	765910.MARPU_13825	1.265e-09	70.0	COG2304@1|root,COG2304@2|Bacteria,1R7GI@1224|Proteobacteria,1S00S@1236|Gammaproteobacteria,1WVZN@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
XH1_k127_1602444_0	243231.GSU1192	1.209e-18	90.0	COG0461@1|root,COG0461@2|Bacteria,1QXNK@1224|Proteobacteria,43E5C@68525|delta/epsilon subdivisions,2X7EZ@28221|Deltaproteobacteria,43VE5@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
XH1_k127_1631017_2	909663.KI867150_gene1108	3.82e-07	52.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria,2MQDM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
XH1_k127_1631017_0	1123274.KB899413_gene869	1.072e-111	372.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
XH1_k127_1631017_1	1121405.dsmv_3408	4.037e-71	252.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2MHTV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
XH1_k127_1636367_1	927658.AJUM01000022_gene1273	6.279e-09	59.0	COG0636@1|root,COG0636@2|Bacteria,4NPFU@976|Bacteroidetes,2FSVQ@200643|Bacteroidia,3XK1U@558415|Marinilabiliaceae	976|Bacteroidetes	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
XH1_k127_1636367_0	1313304.CALK_1283	2.13e-73	265.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	Peptidase_M28,V_ATPase_I
XH1_k127_1660405_0	1379698.RBG1_1C00001G0402	2.416e-134	444.0	COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria	2|Bacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
XH1_k127_1687096_3	747365.Thena_0029	1.134e-31	130.0	COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,42IUS@68295|Thermoanaerobacterales	186801|Clostridia	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
XH1_k127_1687096_2	290402.Cbei_4310	9.559e-38	147.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,36I61@31979|Clostridiaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
XH1_k127_1687096_1	96561.Dole_2971	1.204e-70	244.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,2MJDS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
XH1_k127_1687096_0	1121413.JMKT01000008_gene1194	6.453e-117	382.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2WJ24@28221|Deltaproteobacteria,2M83H@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
XH1_k127_1692858_2	1232437.KL662060_gene4105	1.254e-14	74.0	COG1359@1|root,COG1359@2|Bacteria,1RE0B@1224|Proteobacteria,42VE2@68525|delta/epsilon subdivisions,2WS9H@28221|Deltaproteobacteria,2MKZ9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
XH1_k127_1692858_0	909663.KI867149_gene3218	3.759e-221	691.0	COG2271@1|root,COG2271@2|Bacteria,1QX38@1224|Proteobacteria,42NSX@68525|delta/epsilon subdivisions,2WK8G@28221|Deltaproteobacteria,2MSIF@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
XH1_k127_1692858_1	1298593.TOL_0726	5.158e-38	151.0	COG0834@1|root,COG0834@2|Bacteria,1MYX5@1224|Proteobacteria,1S8HA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
XH1_k127_1718061_0	795359.TOPB45_0418	4.19e-115	379.0	COG0068@1|root,COG0068@2|Bacteria,2GHN8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the carbamoyltransferase HypF family	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
XH1_k127_1718061_1	246194.CHY_2444	2.514e-30	127.0	COG1294@1|root,COG1294@2|Bacteria,1TRYV@1239|Firmicutes,24CPA@186801|Clostridia,42GGD@68295|Thermoanaerobacterales	186801|Clostridia	C	Cytochrome d ubiquinol oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
XH1_k127_1742366_0	1519464.HY22_14250	2.113e-46	177.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
XH1_k127_1743712_1	945713.IALB_2658	6.986e-32	130.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
XH1_k127_1743712_0	1191523.MROS_2033	3.711e-129	419.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
XH1_k127_1753400_0	247490.KSU1_C1278	4.722e-137	447.0	COG0527@1|root,COG0527@2|Bacteria,2IY8N@203682|Planctomycetes	203682|Planctomycetes	E	aspartate kinase, monofunctional class	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
XH1_k127_1753400_1	1071073.KI530537_gene1880	4.635e-97	329.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,4H9KB@91061|Bacilli,1ZDA3@1386|Bacillus	91061|Bacilli	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
XH1_k127_1753400_2	742767.HMPREF9456_01628	1.988e-16	83.0	COG0637@1|root,COG0637@2|Bacteria,4NJS1@976|Bacteroidetes,2FN13@200643|Bacteroidia,22W0C@171551|Porphyromonadaceae	976|Bacteroidetes	S	HAD hydrolase, family IA, variant 3	yfbT	-	-	-	-	-	-	-	-	-	-	-	HAD_2
XH1_k127_1775187_0	1167006.UWK_03195	2.715e-194	622.0	COG3855@1|root,COG3855@2|Bacteria,1R8SF@1224|Proteobacteria,42YMJ@68525|delta/epsilon subdivisions,2WTNP@28221|Deltaproteobacteria,2MNG4@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Firmicute fructose-1,6-bisphosphatase	-	-	3.1.3.11	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_2
XH1_k127_1780246_0	883158.HMPREF9140_00097	1.642e-90	320.0	COG1132@1|root,COG1132@2|Bacteria,4NE2D@976|Bacteroidetes,2FMUK@200643|Bacteroidia	976|Bacteroidetes	V	ABC transporter, ATP-binding protein	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
XH1_k127_1780246_1	926561.KB900617_gene2134	1.337e-68	237.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WA9Z@53433|Halanaerobiales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
XH1_k127_1794972_0	234267.Acid_3816	1.723e-287	906.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,3Y2JQ@57723|Acidobacteria	57723|Acidobacteria	E	glutamate synthase alpha subunit	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
XH1_k127_179740_0	1191523.MROS_1893	1.155e-87	305.0	COG1160@1|root,COG1160@2|Bacteria	2|Bacteria	S	GTP binding	der	GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
XH1_k127_179740_1	477974.Daud_0033	1.214e-69	241.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,2612W@186807|Peptococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
XH1_k127_1798281_1	1123278.KB893553_gene3918	4.492e-54	197.0	arCOG09454@1|root,30G4A@2|Bacteria,4NPSB@976|Bacteroidetes,47Q9D@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_1798281_0	194439.CT1411	7e-119	389.0	COG3968@1|root,COG3968@2|Bacteria,1FD6N@1090|Chlorobi	1090|Chlorobi	S	PFAM glutamine synthetase catalytic region	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
XH1_k127_1801119_1	1410653.JHVC01000019_gene2156	6.107e-06	49.0	COG4642@1|root,COG4642@2|Bacteria,1TRNW@1239|Firmicutes,24GQA@186801|Clostridia,36J8X@31979|Clostridiaceae	186801|Clostridia	S	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases.	-	-	-	-	-	-	-	-	-	-	-	-	MORN
XH1_k127_1801119_0	880073.Calab_0773	7.971e-238	749.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
XH1_k127_1805190_1	574087.Acear_2185	3.332e-64	228.0	COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,24H2B@186801|Clostridia,3WAKF@53433|Halanaerobiales	186801|Clostridia	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
XH1_k127_1805190_0	1392493.JIAB01000001_gene353	3.427e-119	392.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,27IFT@186928|unclassified Lachnospiraceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
XH1_k127_1805190_2	1396141.BATP01000005_gene6062	3.039e-21	98.0	COG1762@1|root,COG1762@2|Bacteria,46VMP@74201|Verrucomicrobia,2IUWS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	-	-	-	-	-	-	-	-	-	PTS_EIIA_2
XH1_k127_1808040_2	1089550.ATTH01000001_gene142	1.054e-07	54.0	COG1826@1|root,COG1826@2|Bacteria,4PETH@976|Bacteroidetes,1FJKH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
XH1_k127_1808040_0	639282.DEFDS_1418	2.997e-155	498.0	COG0136@1|root,COG0136@2|Bacteria,2GF4J@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
XH1_k127_1808040_1	1540257.JQMW01000009_gene3566	2.759e-52	190.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,36DRW@31979|Clostridiaceae	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
XH1_k127_1819808_2	394503.Ccel_0678	1.449e-25	108.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,36E1K@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
XH1_k127_1819808_0	1121403.AUCV01000022_gene3471	4.118e-152	488.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,2MI4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
XH1_k127_1819808_1	1121289.JHVL01000010_gene1376	2.578e-27	115.0	COG2138@1|root,COG2138@2|Bacteria,1TRDV@1239|Firmicutes,24QUN@186801|Clostridia,36KBZ@31979|Clostridiaceae	186801|Clostridia	S	PFAM cobalamin (vitamin B12) biosynthesis CbiX protein	cbiX	-	4.99.1.3,4.99.1.4	ko:K03794,ko:K03795	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R05807	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
XH1_k127_1819808_3	1410653.JHVC01000006_gene28	9.594e-23	99.0	COG2087@1|root,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,36KXJ@31979|Clostridiaceae	186801|Clostridia	H	cobinamide kinase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
XH1_k127_1822164_0	909663.KI867150_gene1458	4.133e-188	591.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
XH1_k127_1822164_1	1265505.ATUG01000001_gene4165	3.434e-76	263.0	COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria,2MIKC@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
XH1_k127_1822164_2	335543.Sfum_2686	1.162e-67	233.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2MQ6N@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
XH1_k127_1862477_1	879212.DespoDRAFT_01387	4.252e-37	143.0	COG0824@1|root,COG0824@2|Bacteria,1RH6W@1224|Proteobacteria	1224|Proteobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
XH1_k127_1862477_0	1122927.KB895414_gene5108	2.927e-54	208.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,4HAU0@91061|Bacilli,2707C@186822|Paenibacillaceae	91061|Bacilli	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
XH1_k127_1898031_0	321332.CYB_2140	1.354e-91	339.0	COG2373@1|root,COG2373@2|Bacteria,1G1A1@1117|Cyanobacteria,1H0M9@1129|Synechococcus	1117|Cyanobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,CarboxypepD_reg,MG1,Thiol-ester_cl
XH1_k127_1898031_3	221027.JO40_08315	2.919e-06	57.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,2J6E8@203691|Spirochaetes	203691|Spirochaetes	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1,LigB
XH1_k127_1898031_1	1487921.DP68_18225	8.877e-37	148.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,36EIZ@31979|Clostridiaceae	186801|Clostridia	V	PFAM VanW family protein	vanW	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
XH1_k127_1898031_2	1167006.UWK_00121	4.535e-14	75.0	COG0204@1|root,COG0204@2|Bacteria,1REJD@1224|Proteobacteria,42RHJ@68525|delta/epsilon subdivisions,2WNBM@28221|Deltaproteobacteria,2MNA2@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
XH1_k127_1919492_2	1307759.JOMJ01000004_gene2895	1.909e-33	130.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,42SAN@68525|delta/epsilon subdivisions,2WP1V@28221|Deltaproteobacteria,2MBYS@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Ribose galactose isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1604	LacAB_rpiB
XH1_k127_1919492_0	338966.Ppro_0044	6.922e-166	529.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,43TWM@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
XH1_k127_1919492_1	1492737.FEM08_14230	2.716e-60	213.0	COG0503@1|root,COG0503@2|Bacteria,4NP7K@976|Bacteroidetes,1I29Z@117743|Flavobacteriia,2NU31@237|Flavobacterium	976|Bacteroidetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
XH1_k127_1981394_0	56780.SYN_02201	1.293e-260	809.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
XH1_k127_1981394_1	1182590.BN5_01218	2.86e-28	114.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1YJYU@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
XH1_k127_1981394_2	472759.Nhal_1474	3.917e-25	107.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1WYJN@135613|Chromatiales	135613|Chromatiales	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
XH1_k127_1989535_2	880072.Desac_2632	5.318e-42	156.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2MQXD@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
XH1_k127_1989535_0	696369.KI912183_gene2573	7.313e-98	325.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,260A5@186807|Peptococcaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
XH1_k127_1989535_1	696281.Desru_3311	2.438e-44	163.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,260A5@186807|Peptococcaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
XH1_k127_2030029_0	247490.KSU1_C0322	9.077e-39	164.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IWXS@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
XH1_k127_2038252_0	1484460.JSWG01000011_gene1763	5.985e-35	151.0	COG0739@1|root,COG0739@2|Bacteria,4NED7@976|Bacteroidetes,1HXKD@117743|Flavobacteriia	976|Bacteroidetes	M	peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
XH1_k127_2041545_4	177437.HRM2_41940	3.478e-18	86.0	COG0394@1|root,COG0655@1|root,COG0394@2|Bacteria,COG0655@2|Bacteria,1NANP@1224|Proteobacteria,42Q16@68525|delta/epsilon subdivisions,2WIJ7@28221|Deltaproteobacteria,2MIC1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,LMWPc
XH1_k127_2041545_3	1410653.JHVC01000040_gene3302	2.655e-24	102.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,36MM3@31979|Clostridiaceae	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
XH1_k127_2041545_0	933262.AXAM01000083_gene762	1.132e-188	595.0	COG0426@1|root,COG0426@2|Bacteria,1R4UD@1224|Proteobacteria,43AF5@68525|delta/epsilon subdivisions,2X5UW@28221|Deltaproteobacteria,2MPG5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Flavodoxin	roo	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B,Lactamase_B_2
XH1_k127_2041545_1	592015.HMPREF1705_01842	4.83e-69	240.0	COG0778@1|root,COG0778@2|Bacteria,3TAZ1@508458|Synergistetes	508458|Synergistetes	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
XH1_k127_2041545_2	1002809.SSIL_1197	2.617e-25	112.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4HAV2@91061|Bacilli,26F62@186818|Planococcaceae	91061|Bacilli	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	mcpA5	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
XH1_k127_2063150_0	545695.TREAZ_1506	2.261e-83	284.0	COG4249@1|root,COG4249@2|Bacteria,2J74C@203691|Spirochaetes	203691|Spirochaetes	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
XH1_k127_2063150_4	483219.LILAB_23860	1.483e-29	128.0	COG5662@1|root,COG5662@2|Bacteria,1Q39S@1224|Proteobacteria,4390Y@68525|delta/epsilon subdivisions,2X465@28221|Deltaproteobacteria,2YYC2@29|Myxococcales	28221|Deltaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2063150_1	391625.PPSIR1_10500	1.668e-48	178.0	COG1595@1|root,COG1595@2|Bacteria,1RHSF@1224|Proteobacteria,438JV@68525|delta/epsilon subdivisions,2X3UH@28221|Deltaproteobacteria,2YX4W@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	HTH_24,Sigma70_r2,Sigma70_r4_2
XH1_k127_2063150_2	526224.Bmur_2633	3.685e-35	153.0	COG4733@1|root,COG4733@2|Bacteria,2JBHZ@203691|Spirochaetes	203691|Spirochaetes	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,fn3
XH1_k127_2063150_3	515622.bpr_I2911	1.617e-31	127.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,4BW9Y@830|Butyrivibrio	186801|Clostridia	J	Probable RNA and SrmB- binding site of polymerase A	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
XH1_k127_2096014_0	290317.Cpha266_0622	2.849e-133	436.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1FDCY@1090|Chlorobi	1090|Chlorobi	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
XH1_k127_2096014_1	589865.DaAHT2_2151	6.282e-74	254.0	COG0348@1|root,COG0348@2|Bacteria,1Q1GZ@1224|Proteobacteria,42TN5@68525|delta/epsilon subdivisions,2WQIA@28221|Deltaproteobacteria,2MNPI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
XH1_k127_2096014_2	439235.Dalk_1151	4.54e-28	125.0	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
XH1_k127_2096750_3	443143.GM18_2350	3.118e-35	149.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1R8QH@1224|Proteobacteria,42T02@68525|delta/epsilon subdivisions,2WPNU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	PFAM WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
XH1_k127_2096750_1	1307761.L21SP2_0140	5.141e-80	286.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
XH1_k127_2096750_0	1304888.ATWF01000001_gene1486	2.045e-148	473.0	COG0752@1|root,COG0752@2|Bacteria,2GEZ4@200930|Deferribacteres	200930|Deferribacteres	J	Glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
XH1_k127_2096750_2	573413.Spirs_2422	2.482e-71	252.0	COG0618@1|root,COG0618@2|Bacteria,2J74X@203691|Spirochaetes	203691|Spirochaetes	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
XH1_k127_2098083_5	56780.SYN_02709	1.567e-60	216.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WNNG@28221|Deltaproteobacteria,2MRMK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
XH1_k127_2098083_2	247490.KSU1_D0415	1.092e-75	266.0	COG0620@1|root,COG0620@2|Bacteria,2J2EU@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2098083_3	771875.Ferpe_0617	4.962e-71	246.0	COG0264@1|root,COG0264@2|Bacteria,2GCGY@200918|Thermotogae	200918|Thermotogae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
XH1_k127_2098083_1	1232410.KI421418_gene2263	1.119e-93	313.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,43SW0@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
XH1_k127_2098083_6	335541.Swol_0885	1.959e-60	214.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,42JUT@68298|Syntrophomonadaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
XH1_k127_2098083_4	1120998.AUFC01000001_gene1925	7.905e-68	239.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,3WD1H@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
XH1_k127_2098083_7	945713.IALB_0622	1.006e-33	141.0	COG4589@1|root,COG4589@2|Bacteria	2|Bacteria	S	phosphatidate cytidylyltransferase activity	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
XH1_k127_2098083_0	1123288.SOV_1c12080	8.552e-109	364.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4H2Q8@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
XH1_k127_2104079_1	879212.DespoDRAFT_00378	5.939e-46	172.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1R561@1224|Proteobacteria,42NEB@68525|delta/epsilon subdivisions,2WM1V@28221|Deltaproteobacteria,2MIB5@213118|Desulfobacterales	28221|Deltaproteobacteria	CJ	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
XH1_k127_2104079_0	572544.Ilyop_1180	1.825e-75	268.0	COG4642@1|root,COG4642@2|Bacteria	2|Bacteria	S	regulation of ryanodine-sensitive calcium-release channel activity	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25,MORN
XH1_k127_2106097_1	243231.GSU1900	6.569e-53	196.0	COG0767@1|root,COG0767@2|Bacteria,1RHNJ@1224|Proteobacteria,42SNW@68525|delta/epsilon subdivisions,2WPKT@28221|Deltaproteobacteria,43T2D@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
XH1_k127_2106097_0	237368.SCABRO_01633	1.919e-74	257.0	COG1127@1|root,COG1127@2|Bacteria,2IXBY@203682|Planctomycetes	203682|Planctomycetes	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
XH1_k127_2106097_2	485915.Dret_0678	0.0003547	46.0	COG1463@1|root,COG1463@2|Bacteria,1RFFS@1224|Proteobacteria,42P4P@68525|delta/epsilon subdivisions,2WKQH@28221|Deltaproteobacteria,2MH3S@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
XH1_k127_2114630_7	572544.Ilyop_0511	3.387e-34	134.0	COG2087@1|root,COG2087@2|Bacteria,37A1F@32066|Fusobacteria	32066|Fusobacteria	H	Adenosylcobinamide kinase adenosylcobinamide-phosphate guanylyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
XH1_k127_2114630_5	526218.Sterm_0999	5.833e-49	184.0	COG0368@1|root,COG0368@2|Bacteria,379H2@32066|Fusobacteria	32066|Fusobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
XH1_k127_2114630_6	431943.CKL_0732	1.158e-41	160.0	COG0406@1|root,COG0406@2|Bacteria,1VEMM@1239|Firmicutes,24GJW@186801|Clostridia,36KFN@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
XH1_k127_2114630_3	96561.Dole_3189	4.432e-53	192.0	COG2519@1|root,COG2519@2|Bacteria	2|Bacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	-	-	-	ko:K13613	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Methyltransf_21
XH1_k127_2114630_8	1158318.ATXC01000002_gene1662	3.832e-31	128.0	COG0241@1|root,COG0241@2|Bacteria,2G469@200783|Aquificae	200783|Aquificae	E	D,D-heptose 1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HAD_2,Hydrolase_like
XH1_k127_2114630_2	1031288.AXAA01000007_gene870	2.012e-66	235.0	COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,36EDU@31979|Clostridiaceae	186801|Clostridia	J	Methyltransferase	rrmJ	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
XH1_k127_2114630_0	1304284.L21TH_0188	1.961e-192	619.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,36DZY@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
XH1_k127_2114630_1	1123274.KB899431_gene3252	1.206e-171	553.0	COG1418@1|root,COG1418@2|Bacteria,2J5IM@203691|Spirochaetes	203691|Spirochaetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
XH1_k127_2114630_4	1089553.Tph_c10050	4.141e-49	179.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,42GEH@68295|Thermoanaerobacterales	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
XH1_k127_2114630_9	634956.Geoth_0291	1.931e-17	83.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HEC8@91061|Bacilli,1WGF9@129337|Geobacillus	91061|Bacilli	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SLH
XH1_k127_2117418_7	1232437.KL661958_gene2896	1.103e-51	184.0	2FA5F@1|root,342E8@2|Bacteria,1NZ65@1224|Proteobacteria,430Q1@68525|delta/epsilon subdivisions,2WVVB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2117418_6	1121405.dsmv_3733	2.359e-71	247.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42SXB@68525|delta/epsilon subdivisions,2WPMK@28221|Deltaproteobacteria,2MKWB@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
XH1_k127_2117418_2	909663.KI867150_gene857	2.584e-180	571.0	COG1063@1|root,COG1063@2|Bacteria,1QVAK@1224|Proteobacteria,43BPR@68525|delta/epsilon subdivisions,2X70Z@28221|Deltaproteobacteria,2MR6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
XH1_k127_2117418_0	706587.Desti_4722	2.84e-281	872.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
XH1_k127_2117418_8	706587.Desti_4721	4.966e-44	162.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2117418_3	706587.Desti_4720	4.37e-180	567.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
XH1_k127_2117418_4	706587.Desti_4719	8.87e-161	511.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
XH1_k127_2117418_5	1379698.RBG1_1C00001G1240	9.78e-76	270.0	COG2239@1|root,COG2239@2|Bacteria,2NP79@2323|unclassified Bacteria	2|Bacteria	P	MgtE intracellular N domain	opuCA	-	3.6.3.32	ko:K02000,ko:K05847	ko02010,map02010	M00208,M00209	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	iSB619.SA_RS12845	ABC_tran,CBS,MgtE_N,PRC
XH1_k127_2117418_1	646529.Desaci_2141	1.18e-185	588.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,24ACU@186801|Clostridia,260WD@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM NRAMP (natural resistance-associated macrophage protein) metal ion transporters	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS07840	Nramp
XH1_k127_212557_1	1125699.HMPREF9194_00599	3.655e-13	72.0	COG4166@1|root,COG4166@2|Bacteria,2J687@203691|Spirochaetes	203691|Spirochaetes	E	extracellular solute-binding protein, family 5	oppA-1	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
XH1_k127_212557_0	556268.OFAG_01922	8.421e-173	564.0	COG0339@1|root,COG0339@2|Bacteria,1R4AJ@1224|Proteobacteria,2VP2M@28216|Betaproteobacteria,476SV@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidase family M3	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
XH1_k127_2126758_0	926561.KB900617_gene1719	6.045e-49	186.0	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WB7F@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,Helicase_C
XH1_k127_2126758_1	555079.Toce_0936	1.904e-28	124.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia,42H5V@68295|Thermoanaerobacterales	186801|Clostridia	L	Reverse transcriptase-like	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
XH1_k127_2126758_2	515635.Dtur_1258	1.32e-10	70.0	COG1579@1|root,COG1579@2|Bacteria	2|Bacteria	-	-	ptsN	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
XH1_k127_215192_2	596324.TREVI0001_2418	5.243e-40	150.0	COG1173@1|root,COG1173@2|Bacteria,2J57E@203691|Spirochaetes	203691|Spirochaetes	EP	ABC transporter (Permease)	oppC-1	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
XH1_k127_215192_0	1480694.DC28_07390	1.551e-123	403.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
XH1_k127_215192_1	632292.Calhy_0870	1.527e-119	392.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,42F38@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
XH1_k127_2152883_0	56110.Oscil6304_0189	3.287e-109	375.0	COG0642@1|root,COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,1G3F2@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE1,Response_reg
XH1_k127_2152883_1	1232410.KI421428_gene1164	1.542e-60	213.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,43SC9@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Amino acid kinase family	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
XH1_k127_2159850_1	290318.Cvib_1767	2.412e-48	184.0	COG0705@1|root,COG0705@2|Bacteria,1FDF1@1090|Chlorobi	1090|Chlorobi	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
XH1_k127_2159850_0	1304885.AUEY01000091_gene1629	8.067e-60	216.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42M4Y@68525|delta/epsilon subdivisions,2WKKD@28221|Deltaproteobacteria,2MIK0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
XH1_k127_2166914_1	1345695.CLSA_c22720	8.331e-16	78.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,36EKX@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
XH1_k127_2166914_3	1535422.ND16A_2450	1.725e-05	53.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,2Q6RI@267889|Colwelliaceae	1236|Gammaproteobacteria	D	TolA binding protein trimerisation	cpoB	GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
XH1_k127_2166914_0	1121405.dsmv_1876	3.944e-176	572.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2MJ2H@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Acetyl-CoA dehydrogenase-like C-terminal domain, Acyl-CoA dehydrogenase domain-containing protein, acyl-CoA dehydrogenase domain-containing protein	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
XH1_k127_2171491_0	398767.Glov_3328	8.503e-118	409.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WTPC@28221|Deltaproteobacteria,43TG7@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
XH1_k127_2171491_1	386456.JQKN01000002_gene2432	9.283e-21	93.0	COG2231@1|root,arCOG00461@2157|Archaea,2Y86S@28890|Euryarchaeota,23PBV@183925|Methanobacteria	183925|Methanobacteria	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
XH1_k127_2179480_0	889378.Spiaf_0365	5.535e-73	254.0	2EYA0@1|root,33RIG@2|Bacteria,2J6Q4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2179480_1	1122176.KB903531_gene2875	3.487e-05	52.0	COG1366@1|root,COG1366@2|Bacteria,4NTPB@976|Bacteroidetes,1ISU9@117747|Sphingobacteriia	976|Bacteroidetes	T	transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
XH1_k127_2179480_2	1123229.AUBC01000014_gene2923	0.0002274	44.0	COG1409@1|root,COG1409@2|Bacteria,1R70J@1224|Proteobacteria,2U3CS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
XH1_k127_2204828_0	484022.Fphi_0479	8.379e-53	201.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales	72273|Thiotrichales	LU	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
XH1_k127_2204828_1	1123274.KB899421_gene1723	1.3e-39	151.0	COG0537@1|root,COG0537@2|Bacteria,2JAFV@203691|Spirochaetes	203691|Spirochaetes	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
XH1_k127_221599_1	1047013.AQSP01000097_gene1949	3.63e-68	262.0	COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.11.1,4.6.1.1	ko:K01768,ko:K12132	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	DUF3467,GGDEF,PAS_9
XH1_k127_221599_3	138119.DSY1064	4.397e-10	74.0	COG0745@1|root,COG0745@2|Bacteria,1TSNV@1239|Firmicutes,2493A@186801|Clostridia,260YI@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
XH1_k127_221599_0	350688.Clos_0539	9.17e-120	394.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,36F1W@31979|Clostridiaceae	186801|Clostridia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
XH1_k127_2233061_0	889378.Spiaf_0116	0.0	1888.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2J5ZA@203691|Spirochaetes	203691|Spirochaetes	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
XH1_k127_2233061_1	1121405.dsmv_0428	1.117e-216	679.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
XH1_k127_2233061_2	665571.STHERM_c16250	9.542e-89	299.0	COG0476@1|root,COG0476@2|Bacteria,2J75K@203691|Spirochaetes	203691|Spirochaetes	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
XH1_k127_2233061_3	1379698.RBG1_1C00001G1876	1.859e-47	177.0	COG0301@1|root,COG0301@2|Bacteria,2NP8U@2323|unclassified Bacteria	2|Bacteria	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI,tRNA_Me_trans
XH1_k127_2255585_1	868595.Desca_1562	1.473e-09	61.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,260Y2@186807|Peptococcaceae	186801|Clostridia	S	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,NTP_transf_3
XH1_k127_2255585_0	1121423.JONT01000002_gene2208	3.597e-93	316.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,2617B@186807|Peptococcaceae	186801|Clostridia	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
XH1_k127_2264524_0	1267535.KB906767_gene1746	2.452e-107	367.0	COG0072@1|root,COG0072@2|Bacteria,3Y353@57723|Acidobacteria,2JIM2@204432|Acidobacteriia	204432|Acidobacteriia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB
XH1_k127_2294641_0	754027.HMPREF9554_00730	7.263e-48	184.0	COG2199@1|root,COG3706@2|Bacteria,2J5S2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
XH1_k127_2294641_1	744872.Spica_2521	6.83e-46	178.0	COG2199@1|root,COG3706@2|Bacteria,2J6RG@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
XH1_k127_2294641_2	889378.Spiaf_2786	3.373e-32	128.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2J5CT@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD
XH1_k127_2337778_2	926561.KB900620_gene2997	6.787e-27	115.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WBGE@53433|Halanaerobiales	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
XH1_k127_2337778_0	1158318.ATXC01000001_gene1170	2.103e-61	214.0	COG2131@1|root,COG2131@2|Bacteria	2|Bacteria	F	dCMP deaminase activity	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
XH1_k127_2337778_1	96561.Dole_3240	2.788e-29	121.0	COG1586@1|root,COG1586@2|Bacteria,1REQP@1224|Proteobacteria,42RVE@68525|delta/epsilon subdivisions,2WNJ5@28221|Deltaproteobacteria,2MJVH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	S-adenosylmethionine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	AdoMet_dc
XH1_k127_2339193_0	404380.Gbem_0837	3.768e-77	274.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,43T9B@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
XH1_k127_2339193_1	1202962.KB907150_gene1721	8.633e-64	226.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
XH1_k127_2340843_3	926569.ANT_17740	1.132e-53	198.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria,2G9GZ@200795|Chloroflexi	200795|Chloroflexi	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2
XH1_k127_2340843_1	903818.KI912268_gene1464	6.502e-91	314.0	COG0642@1|root,COG2205@2|Bacteria	903818.KI912268_gene1464|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2340843_0	909663.KI867150_gene2575	3.113e-182	578.0	COG2271@1|root,COG2271@2|Bacteria,1QYDE@1224|Proteobacteria,43CG4@68525|delta/epsilon subdivisions,2X7R5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
XH1_k127_2340843_2	909663.KI867150_gene1147	2.652e-79	276.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,42T3V@68525|delta/epsilon subdivisions,2X2EJ@28221|Deltaproteobacteria,2MSD1@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
XH1_k127_2340843_4	1293597.BN147_09150	3.383e-09	67.0	COG0500@1|root,COG0789@1|root,COG0789@2|Bacteria,COG2226@2|Bacteria,1TSDZ@1239|Firmicutes,4HBGU@91061|Bacilli,3FC6A@33958|Lactobacillaceae	91061|Bacilli	KQ	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,Methyltransf_11
XH1_k127_2340843_5	399550.Smar_1415	1.651e-05	53.0	COG2425@1|root,arCOG00442@2157|Archaea,2XQ5T@28889|Crenarchaeota	28889|Crenarchaeota	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3,VWA_CoxE
XH1_k127_2343438_0	1499967.BAYZ01000028_gene1265	8.819e-168	538.0	COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
XH1_k127_2343438_1	1499967.BAYZ01000028_gene1264	1.043e-118	401.0	COG1181@1|root,COG1181@2|Bacteria,2NRF0@2323|unclassified Bacteria	2|Bacteria	M	ATP-grasp domain	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
XH1_k127_2343438_2	756272.Plabr_4555	1.211e-33	148.0	COG1181@1|root,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
XH1_k127_2352608_0	1232437.KL662006_gene4362	7.446e-36	143.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI4B@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
XH1_k127_2352608_1	96561.Dole_0214	1.548e-34	139.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MC0@68525|delta/epsilon subdivisions,2WJIC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25,3.6.3.29,3.6.3.55	ko:K02017,ko:K02045,ko:K15497	ko00920,ko02010,map00920,map02010	M00185,M00189,M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE_2,TOBE_3
XH1_k127_2356872_2	269799.Gmet_3163	4.744e-73	254.0	COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,42PX9@68525|delta/epsilon subdivisions,2WIPW@28221|Deltaproteobacteria,43TZ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	SMART Elongator protein 3 MiaB NifB	yhcC-1	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
XH1_k127_2356872_1	880073.Calab_0995	3.429e-110	361.0	COG0501@1|root,COG0501@2|Bacteria,2NS4G@2323|unclassified Bacteria	2|Bacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
XH1_k127_2356872_5	880073.Calab_0831	7.136e-06	58.0	COG5616@1|root,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,TPR_16
XH1_k127_2356872_3	592015.HMPREF1705_00097	2.766e-47	171.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	yurZ	-	2.3.1.12,4.1.1.44	ko:K00627,ko:K01607	ko00010,ko00020,ko00362,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00020,map00362,map00620,map01100,map01110,map01120,map01130,map01200,map01220	M00307	R00209,R02569,R03470	RC00004,RC00938,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CMD
XH1_k127_2356872_0	1519464.HY22_02015	2.9e-115	382.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
XH1_k127_2356872_4	522772.Dacet_1396	1.415e-28	119.0	COG1215@1|root,COG1215@2|Bacteria,2GFVK@200930|Deferribacteres	200930|Deferribacteres	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
XH1_k127_2369315_0	203119.Cthe_0466	4.695e-56	208.0	COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia,3WHE9@541000|Ruminococcaceae	186801|Clostridia	N	flagellar motor switch protein	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
XH1_k127_2369315_1	204669.Acid345_1154	2.049e-30	128.0	COG0741@1|root,COG0741@2|Bacteria,3Y84I@57723|Acidobacteria,2JNI1@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
XH1_k127_2369315_2	888055.HMPREF9015_00613	1.066e-14	83.0	COG1762@1|root,COG1762@2|Bacteria,379WR@32066|Fusobacteria	32066|Fusobacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
XH1_k127_2399895_1	1123274.KB899415_gene2485	7.679e-40	151.0	COG0335@1|root,COG0335@2|Bacteria,2J8P4@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
XH1_k127_2399895_0	390236.BafPKo_0723	1.581e-69	242.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
XH1_k127_2399895_4	1232449.BAHV02000012_gene2183	3.016e-14	79.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes	1239|Firmicutes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
XH1_k127_2399895_2	1123274.KB899415_gene2482	9.796e-27	111.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
XH1_k127_2399895_3	264732.Moth_0967	1.523e-23	103.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,42GTF@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
XH1_k127_242330_3	1293054.HSACCH_00967	2.488e-20	91.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,3WA9W@53433|Halanaerobiales	186801|Clostridia	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
XH1_k127_242330_2	526222.Desal_1070	5.388e-39	154.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,42U9T@68525|delta/epsilon subdivisions,2WQPQ@28221|Deltaproteobacteria,2MCJT@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
XH1_k127_242330_0	96561.Dole_1611	2.494e-74	256.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,42RFG@68525|delta/epsilon subdivisions,2WPKN@28221|Deltaproteobacteria,2MK0P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
XH1_k127_242330_1	1121405.dsmv_0592	6.016e-51	186.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,42RU9@68525|delta/epsilon subdivisions,2WNP7@28221|Deltaproteobacteria,2MJU6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
XH1_k127_2425088_2	888060.HMPREF9081_1041	7.406e-12	69.0	COG0839@1|root,COG0839@2|Bacteria,1VAQI@1239|Firmicutes,4H4S3@909932|Negativicutes	909932|Negativicutes	C	NADH-ubiquinone plastoquinone oxidoreductase chain 6	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
XH1_k127_2425088_1	357244.OTBS_2161	5.882e-26	114.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,47F77@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3,1.6.99.3	ko:K00338,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	Fer4
XH1_k127_2425088_0	747365.Thena_1751	2.923e-83	286.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,42FT6@68295|Thermoanaerobacterales	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
XH1_k127_2454524_3	1121946.AUAX01000052_gene8128	0.0003269	51.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D8KT@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
XH1_k127_2454524_2	759914.BP951000_0540	1.437e-24	105.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2454524_0	1304880.JAGB01000001_gene879	1.041e-114	384.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
XH1_k127_2454524_1	1304866.K413DRAFT_3074	2.701e-27	114.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,36FI0@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
XH1_k127_2456414_4	1125863.JAFN01000001_gene1230	5.492e-30	119.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42Y7P@68525|delta/epsilon subdivisions,2WUJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
XH1_k127_2456414_2	909663.KI867150_gene2003	2.15e-66	235.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MQGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
XH1_k127_2456414_1	138119.DSY3371	3.397e-82	284.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,260BA@186807|Peptococcaceae	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
XH1_k127_2456414_0	909663.KI867150_gene2005	6.943e-128	423.0	COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,42PTE@68525|delta/epsilon subdivisions,2WK6W@28221|Deltaproteobacteria,2MQQ4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Thi4 family	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	-
XH1_k127_2456414_3	909663.KI867150_gene2006	2.466e-31	125.0	COG2440@1|root,COG2440@2|Bacteria,1RHTX@1224|Proteobacteria,42W4T@68525|delta/epsilon subdivisions,2X9T1@28221|Deltaproteobacteria,2MSGU@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	-	ko:K03855	-	-	-	-	ko00000	-	-	-	ETF_QO
XH1_k127_2457293_1	1123288.SOV_1c13260	6.509e-06	56.0	2EDX0@1|root,337S1@2|Bacteria,1VEE7@1239|Firmicutes,4H6YG@909932|Negativicutes	909932|Negativicutes	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
XH1_k127_2457293_0	907348.TresaDRAFT_0057	9.622e-104	344.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
XH1_k127_2500152_1	744872.Spica_0772	6.212e-58	216.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
XH1_k127_2500152_0	1123274.KB899428_gene1852	2.73e-58	208.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
XH1_k127_2514699_2	502025.Hoch_3614	5.894e-11	65.0	COG1196@1|root,COG1716@1|root,COG5164@1|root,COG1196@2|Bacteria,COG1716@2|Bacteria,COG5164@2|Bacteria	2|Bacteria	K	cell wall organization	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF11,FHA,HATPase_c,HTH_8,HisKA,PAS_3,Response_reg,Sigma54_activat,Yop-YscD_cpl
XH1_k127_2514699_1	309799.DICTH_1431	7.652e-62	220.0	COG1139@1|root,COG1139@2|Bacteria	2|Bacteria	C	lactate oxidation	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
XH1_k127_2514699_0	1207055.C100_17900	1.229e-179	584.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2K1V7@204457|Sphingomonadales	204457|Sphingomonadales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
XH1_k127_2544642_2	933262.AXAM01000014_gene236	5.154e-110	363.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2WK1X@28221|Deltaproteobacteria,2MJBE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
XH1_k127_2544642_0	439235.Dalk_3475	3.521e-143	460.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria,2MHQ8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
XH1_k127_2544642_1	243231.GSU3158	3.676e-122	398.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,43UFR@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
XH1_k127_2550433_0	573413.Spirs_3116	2.387e-77	267.0	COG1226@1|root,COG1226@2|Bacteria,2J72E@203691|Spirochaetes	203691|Spirochaetes	P	TrkA-N domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
XH1_k127_2550433_1	889378.Spiaf_1725	1.608e-34	138.0	COG0664@1|root,COG0664@2|Bacteria,2J8WG@203691|Spirochaetes	203691|Spirochaetes	T	Cyclic nucleotide binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
XH1_k127_2550764_0	319225.Plut_1669	4.281e-181	571.0	COG0369@1|root,COG1151@2|Bacteria,1FD7I@1090|Chlorobi	1090|Chlorobi	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
XH1_k127_2550764_1	351160.LRC562	4.353e-118	385.0	COG1145@1|root,arCOG00296@2157|Archaea,2XUE5@28890|Euryarchaeota,2N9Z6@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21
XH1_k127_2550764_3	1047013.AQSP01000119_gene1318	3.548e-39	152.0	COG4843@1|root,COG4843@2|Bacteria,2NPKB@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
XH1_k127_2550764_4	639282.DEFDS_0180	9.116e-21	96.0	COG0792@1|root,COG0792@2|Bacteria,2GG16@200930|Deferribacteres	200930|Deferribacteres	L	Nuclease-related domain	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
XH1_k127_2550764_2	1480694.DC28_01835	1.343e-64	236.0	COG2206@1|root,COG2206@2|Bacteria,2J6GF@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
XH1_k127_2550764_5	1304888.ATWF01000001_gene2364	5.173e-14	75.0	COG2257@1|root,COG2257@2|Bacteria,2GG1I@200930|Deferribacteres	200930|Deferribacteres	S	FlhB HrpN YscU SpaS Family	-	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
XH1_k127_2566291_0	903818.KI912268_gene2296	6.838e-59	227.0	2DSRS@1|root,33H75@2|Bacteria	2|Bacteria	S	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
XH1_k127_2589270_0	871968.DESME_13755	3.64e-58	207.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,261IR@186807|Peptococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
XH1_k127_2591521_0	323259.Mhun_2195	2.978e-38	153.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NBJ4@224756|Methanomicrobia	224756|Methanomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
XH1_k127_2595637_0	906968.Trebr_1170	1.644e-77	274.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
XH1_k127_2595637_1	65393.PCC7424_5828	1.428e-14	81.0	COG1573@1|root,COG1573@2|Bacteria,1FZYH@1117|Cyanobacteria,3KJUG@43988|Cyanothece	1117|Cyanobacteria	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
XH1_k127_2596937_1	938288.HG326224_gene1426	1.999e-75	264.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,26885@186813|unclassified Clostridiales	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
XH1_k127_2596937_0	795359.TOPB45_0494	7.92e-76	261.0	COG0846@1|root,COG0846@2|Bacteria,2GHHA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
XH1_k127_2596937_2	1313421.JHBV01000007_gene4246	2.044e-10	66.0	COG4249@1|root,COG4642@1|root,COG4249@2|Bacteria,COG4642@2|Bacteria,4NKYQ@976|Bacteroidetes,1IZAN@117747|Sphingobacteriia	976|Bacteroidetes	L	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	MORN,Peptidase_C14
XH1_k127_2612012_3	1121403.AUCV01000093_gene2573	1.108e-19	95.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1N47P@1224|Proteobacteria,42W9J@68525|delta/epsilon subdivisions,2WSBM@28221|Deltaproteobacteria,2MKZR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	PAS_3
XH1_k127_2612012_1	706587.Desti_4234	2.349e-90	304.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,42R5R@68525|delta/epsilon subdivisions,2WMRR@28221|Deltaproteobacteria,2MR65@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
XH1_k127_2612012_2	706587.Desti_4233	8.016e-87	293.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,43AMP@68525|delta/epsilon subdivisions,2X61S@28221|Deltaproteobacteria,2MRRT@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
XH1_k127_2612012_0	1121403.AUCV01000019_gene3292	2.512e-106	355.0	COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,42UTS@68525|delta/epsilon subdivisions,2WQM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
XH1_k127_2634972_2	1349822.NSB1T_06795	2.221e-18	88.0	arCOG09714@1|root,316P9@2|Bacteria,4NRUH@976|Bacteroidetes,2FTNZ@200643|Bacteroidia,22YF0@171551|Porphyromonadaceae	976|Bacteroidetes	S	COG NOG16854 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2634972_0	158189.SpiBuddy_0424	8.195e-118	384.0	COG0428@1|root,COG0428@2|Bacteria,2J9X0@203691|Spirochaetes	203691|Spirochaetes	P	Mediates zinc uptake. May also transport other divalent cations	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
XH1_k127_2634972_1	926550.CLDAP_37780	1.312e-37	144.0	COG0475@1|root,COG0490@1|root,COG0569@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG0569@2|Bacteria	2|Bacteria	P	domain protein	MA20_07375	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
XH1_k127_2638297_1	573413.Spirs_3798	7.816e-113	396.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
XH1_k127_2638297_0	326297.Sama_2571	6.693e-121	398.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,2Q8YC@267890|Shewanellaceae	1236|Gammaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
XH1_k127_2638297_2	665952.HMPREF1015_03282	8.408e-43	157.0	2AU0F@1|root,31JKB@2|Bacteria,1V6XX@1239|Firmicutes,4IN73@91061|Bacilli,1ZMYR@1386|Bacillus	91061|Bacilli	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2643532_1	717231.Flexsi_1483	4.569e-18	89.0	COG0779@1|root,COG0779@2|Bacteria,2GFVG@200930|Deferribacteres	200930|Deferribacteres	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
XH1_k127_2643532_0	744872.Spica_1353	1.402e-107	364.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
XH1_k127_2651152_2	1196322.A370_04286	0.0001866	50.0	COG3688@1|root,COG3688@2|Bacteria,1V9XR@1239|Firmicutes,24MPI@186801|Clostridia,36I6R@31979|Clostridiaceae	186801|Clostridia	S	RNA-binding protein	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
XH1_k127_2651152_0	1235798.C817_05249	1.295e-130	428.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,27V8H@189330|Dorea	186801|Clostridia	E	COG COG0436 Aspartate tyrosine aromatic aminotransferase	aspC	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
XH1_k127_2651152_1	1232410.KI421415_gene3111	1.026e-91	311.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,42M34@68525|delta/epsilon subdivisions,2WKJ6@28221|Deltaproteobacteria,43S5Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
XH1_k127_2662219_1	1304880.JAGB01000005_gene2434	5.43e-111	362.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
XH1_k127_2662219_0	1379698.RBG1_1C00001G0271	2.639e-266	833.0	COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
XH1_k127_2662219_2	526218.Sterm_0004	1.612e-05	52.0	COG5512@1|root,COG5512@2|Bacteria,37ATF@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
XH1_k127_2691204_0	221288.JH992901_gene1951	1.162e-88	305.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1GHCI@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CBS,CheB_methylest,CheR,CheR_N,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9
XH1_k127_2691204_1	443144.GM21_1812	8.45e-56	216.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,43T3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
XH1_k127_2697053_0	1168289.AJKI01000011_gene423	1.747e-83	293.0	COG0621@1|root,COG0621@2|Bacteria,4NE0R@976|Bacteroidetes,2FM1T@200643|Bacteroidia,3XJD0@558415|Marinilabiliaceae	976|Bacteroidetes	J	Uncharacterized protein family UPF0004	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,UPF0004
XH1_k127_2697053_1	1379698.RBG1_1C00001G1836	9.136e-19	91.0	COG0558@1|root,COG0558@2|Bacteria,2NPRA@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
XH1_k127_2697507_2	861299.J421_1499	1.284e-17	93.0	COG5616@1|root,COG5616@2|Bacteria,1ZTN3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidoglycan-synthase activator LpoB	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
XH1_k127_2697507_3	309799.DICTH_1681	7.604e-09	68.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	ydiM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
XH1_k127_2697507_0	443143.GM18_2758	2.61e-224	706.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,43VZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
XH1_k127_2697507_1	443143.GM18_2758	2.234e-100	331.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,43VZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
XH1_k127_2706660_0	748449.Halha_2433	4.182e-13	77.0	COG1452@1|root,COG1452@2|Bacteria,1W2IS@1239|Firmicutes	1239|Firmicutes	M	Organic solvent tolerance protein OstA	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
XH1_k127_2706660_1	673860.AciM339_0570	1.708e-10	74.0	COG0457@1|root,arCOG03042@1|root,arCOG03032@2157|Archaea,arCOG03042@2157|Archaea,2Y7M7@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
XH1_k127_2729657_0	1158345.JNLL01000001_gene1088	5.628e-119	389.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266,2.4.1.268	ko:K13693,ko:K21349	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
XH1_k127_2729657_3	1379281.AVAG01000066_gene1183	7.395e-06	57.0	298GU@1|root,2ZVMX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2729657_2	584708.Apau_2119	3.733e-09	67.0	COG1462@1|root,COG1462@2|Bacteria,3TB3V@508458|Synergistetes	508458|Synergistetes	M	PFAM Curli production assembly transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
XH1_k127_2729657_1	177437.HRM2_10030	7.954e-41	153.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,2MIWJ@213118|Desulfobacterales	28221|Deltaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
XH1_k127_2762099_0	1349822.NSB1T_00890	1.883e-179	578.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia,22WNP@171551|Porphyromonadaceae	976|Bacteroidetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
XH1_k127_2762099_3	596324.TREVI0001_2427	0.0007303	48.0	2AMV7@1|root,31CRX@2|Bacteria,2J8MV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2762099_1	545695.TREAZ_1623	1.641e-43	165.0	COG1595@1|root,COG1595@2|Bacteria,2J7DE@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
XH1_k127_2762099_2	744872.Spica_0334	9.66e-24	104.0	2AN0C@1|root,31CXK@2|Bacteria,2J95I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2797196_2	457396.CSBG_01858	4.439e-97	331.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,36E03@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
XH1_k127_2797196_1	933262.AXAM01000025_gene3401	1.134e-121	398.0	COG1830@1|root,COG1830@2|Bacteria,1MWJW@1224|Proteobacteria,42PHA@68525|delta/epsilon subdivisions,2WKBX@28221|Deltaproteobacteria,2MK4V@213118|Desulfobacterales	28221|Deltaproteobacteria	G	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
XH1_k127_2797196_0	316067.Geob_1850	6.042e-204	641.0	COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Ketose-bisphosphate aldolase, class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
XH1_k127_2797196_3	696747.NIES39_A00950	8.241e-07	62.0	COG0664@1|root,COG1413@1|root,COG3202@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,COG3202@2|Bacteria,1G2QW@1117|Cyanobacteria,1H8CY@1150|Oscillatoriales	1117|Cyanobacteria	CT	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,cNMP_binding
XH1_k127_2807949_1	1499967.BAYZ01000074_gene2157	1.05e-24	112.0	COG2172@1|root,COG2204@1|root,COG2172@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	rsbW	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
XH1_k127_2807949_0	485915.Dret_1422	5.497e-175	556.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2M9I5@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
XH1_k127_2807949_2	1395513.P343_13830	2.049e-08	61.0	COG0671@1|root,COG0671@2|Bacteria,1V33Y@1239|Firmicutes	1239|Firmicutes	I	Membrane-associated phospholipid phosphatase	pgpB1	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
XH1_k127_282177_0	7739.XP_002595643.1	1.041e-23	109.0	KOG3714@1|root,KOG3714@2759|Eukaryota,39TYY@33154|Opisthokonta,3BNPT@33208|Metazoa,3D394@33213|Bilateria	33208|Metazoa	O	Astacin (Peptidase family M12A)	-	GO:0007275,GO:0007610,GO:0007631,GO:0008150,GO:0032501,GO:0032502,GO:0035295,GO:0042755,GO:0043050,GO:0048565,GO:0048731,GO:0048856,GO:0055123,GO:0060465	3.4.24.21	ko:K08076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Astacin,ShK
XH1_k127_283335_0	1304885.AUEY01000009_gene1927	2.655e-158	524.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
XH1_k127_283335_3	667014.Thein_1317	2.657e-49	179.0	COG1051@1|root,COG1051@2|Bacteria,2GI88@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
XH1_k127_283335_1	1289135.A966_05778	6.075e-106	350.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
XH1_k127_283335_2	123214.PERMA_0311	1.66e-63	229.0	COG1522@1|root,COG1522@2|Bacteria,2G4TH@200783|Aquificae	200783|Aquificae	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_2838955_1	592031.GCWU000322_00607	1.303e-42	160.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,25W7A@186806|Eubacteriaceae	186801|Clostridia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
XH1_k127_2838955_2	1121035.AUCH01000004_gene342	1.503e-11	70.0	2ADX9@1|root,313PE@2|Bacteria,1RGY0@1224|Proteobacteria,2VUGJ@28216|Betaproteobacteria,2KZEY@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2846
XH1_k127_2838955_0	880072.Desac_0492	7.675e-122	414.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MSIC@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
XH1_k127_2912918_1	1121423.JONT01000007_gene611	2.474e-37	147.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
XH1_k127_2912918_0	903818.KI912269_gene422	5.94e-81	276.0	COG0017@1|root,COG0017@2|Bacteria	2|Bacteria	J	Asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2
XH1_k127_2936351_1	443144.GM21_2257	1.062e-45	173.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
XH1_k127_2936351_0	1122619.KB892324_gene39	1.522e-53	198.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,3T28Q@506|Alcaligenaceae	28216|Betaproteobacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
XH1_k127_2961068_0	909663.KI867150_gene788	1.617e-102	340.0	COG1073@1|root,COG1073@2|Bacteria,1R1JJ@1224|Proteobacteria,43EIA@68525|delta/epsilon subdivisions,2WTC5@28221|Deltaproteobacteria,2MR3E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
XH1_k127_2993327_0	1293054.HSACCH_01245	6.353e-96	329.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,3WBC7@53433|Halanaerobiales	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
XH1_k127_2993327_1	1123240.ATVO01000005_gene1728	6.915e-08	55.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,2K6WZ@204457|Sphingomonadales	204457|Sphingomonadales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
XH1_k127_2993757_2	1122915.AUGY01000013_gene2923	7.168e-71	244.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4HATT@91061|Bacilli,26SI9@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
XH1_k127_2993757_3	909663.KI867150_gene2141	1.646e-35	138.0	COG0662@1|root,COG0662@2|Bacteria,1NESW@1224|Proteobacteria,43AWH@68525|delta/epsilon subdivisions,2WW1I@28221|Deltaproteobacteria,2MSKD@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	MannoseP_isomer
XH1_k127_2993757_0	573413.Spirs_0361	1.631e-98	330.0	COG1131@1|root,COG1131@2|Bacteria,2J5JM@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
XH1_k127_2993757_1	1232437.KL662006_gene4427	2.232e-80	275.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
XH1_k127_3008132_1	316067.Geob_1063	9.626e-138	446.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42M8Y@68525|delta/epsilon subdivisions,2WIZG@28221|Deltaproteobacteria,43T0G@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
XH1_k127_3008132_2	243231.GSU2056	2.552e-35	139.0	COG3090@1|root,COG3090@2|Bacteria,1REB9@1224|Proteobacteria,42RXU@68525|delta/epsilon subdivisions,2WNAT@28221|Deltaproteobacteria,43VKG@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
XH1_k127_3008132_0	243231.GSU2057	6.67e-201	633.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,43UEI@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
XH1_k127_3034131_0	1449126.JQKL01000003_gene1745	1.616e-152	490.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,267M9@186813|unclassified Clostridiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
XH1_k127_3034658_1	1041930.Mtc_0591	4.857e-06	57.0	arCOG03042@1|root,arCOG03042@2157|Archaea	2157|Archaea	KLT	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2
XH1_k127_3034658_0	526218.Sterm_1805	8.641e-79	276.0	COG0836@1|root,COG0836@2|Bacteria,378HX@32066|Fusobacteria	32066|Fusobacteria	M	mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
XH1_k127_3039008_1	158190.SpiGrapes_2188	7.141e-46	183.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
XH1_k127_3039008_0	269799.Gmet_2728	6.061e-176	571.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
XH1_k127_3072871_1	1379698.RBG1_1C00001G1274	6.967e-17	91.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	atoC	-	-	ko:K07712,ko:K07713,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00497,M00499,M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
XH1_k127_3072871_0	439292.Bsel_1128	5.847e-46	170.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,4HGZX@91061|Bacilli,26NRQ@186821|Sporolactobacillaceae	91061|Bacilli	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
XH1_k127_310281_0	1121405.dsmv_1387	8.758e-93	312.0	COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,43BPW@68525|delta/epsilon subdivisions,2X714@28221|Deltaproteobacteria,2MPJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
XH1_k127_310281_1	1280953.HOC_00655	8.576e-05	51.0	2F86S@1|root,340K3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_3128779_0	795359.TOPB45_1456	2.261e-128	423.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GH4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
XH1_k127_3128779_1	1122176.KB903535_gene1980	7.612e-75	261.0	COG0181@1|root,COG0181@2|Bacteria,4NHH4@976|Bacteroidetes,1IQUA@117747|Sphingobacteriia	976|Bacteroidetes	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Porphobil_deam,Porphobil_deamC
XH1_k127_3128779_4	1499967.BAYZ01000163_gene6587	8.566e-18	88.0	COG0782@1|root,COG0782@2|Bacteria	2|Bacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	rnk	-	-	ko:K03624,ko:K06140	-	-	-	-	ko00000,ko03000,ko03021	-	-	-	Acetyltransf_3,GreA_GreB,Rnk_N
XH1_k127_3128779_2	459349.CLOAM1624	5.448e-31	141.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,2NPWP@2323|unclassified Bacteria	2|Bacteria	M	OmpA family	pal	-	-	ko:K03286,ko:K03640	-	-	-	-	ko00000,ko02000	1.B.6,2.C.1.2	-	-	CarboxypepD_reg,OmpA,PD40
XH1_k127_3128779_3	439235.Dalk_3755	1.392e-27	123.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WM56@28221|Deltaproteobacteria,2MHKW@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
XH1_k127_3165162_2	526224.Bmur_2097	1.265e-116	378.0	COG2873@1|root,COG2873@2|Bacteria,2J5MU@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Cys Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
XH1_k127_3165162_1	697282.Mettu_2273	1.108e-144	464.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XDN6@135618|Methylococcales	135618|Methylococcales	H	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
XH1_k127_3165162_0	59374.Fisuc_3113	4.559e-158	516.0	COG0500@1|root,COG2021@1|root,COG2021@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,MetW
XH1_k127_3165162_4	56780.SYN_03008	5.151e-39	150.0	COG1959@1|root,COG1959@2|Bacteria,1PC6N@1224|Proteobacteria,43EVM@68525|delta/epsilon subdivisions,2X9SC@28221|Deltaproteobacteria,2MSFF@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
XH1_k127_3165162_3	760011.Spico_0283	3.356e-50	184.0	COG0482@1|root,COG0482@2|Bacteria,2J6BI@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
XH1_k127_3174134_1	1123508.JH636445_gene6802	2.906e-09	61.0	COG0360@1|root,COG0360@2|Bacteria,2J0U0@203682|Planctomycetes	203682|Planctomycetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
XH1_k127_3174134_0	517418.Ctha_2056	2.71e-76	272.0	COG0265@1|root,COG0265@2|Bacteria,1FDIE@1090|Chlorobi	1090|Chlorobi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
XH1_k127_3200416_3	479434.Sthe_1871	2.191e-05	47.0	COG4401@1|root,COG4401@2|Bacteria,2G6VB@200795|Chloroflexi,27YKI@189775|Thermomicrobia	189775|Thermomicrobia	E	Chorismate mutase type I	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
XH1_k127_3200416_0	1195236.CTER_2389	3.361e-145	471.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WG99@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
XH1_k127_3200416_2	502025.Hoch_3614	7.506e-10	65.0	COG1196@1|root,COG1716@1|root,COG5164@1|root,COG1196@2|Bacteria,COG1716@2|Bacteria,COG5164@2|Bacteria	2|Bacteria	K	cell wall organization	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF11,FHA,HATPase_c,HTH_8,HisKA,PAS_3,Response_reg,Sigma54_activat,Yop-YscD_cpl
XH1_k127_3200416_1	1123288.SOV_2c00260	4.332e-34	135.0	COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,4H92Z@909932|Negativicutes	909932|Negativicutes	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
XH1_k127_328739_1	673860.AciM339_0137	6.514e-53	191.0	COG1853@1|root,arCOG02017@2157|Archaea,2XXVW@28890|Euryarchaeota,3F365@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Flavin reductase like domain	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016722,GO:0016723,GO:0032553,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.16.1.10	ko:K18915	-	-	-	-	ko00000,ko01000	-	-	-	Flavin_Reduct
XH1_k127_328739_0	1237149.C900_02954	2.648e-94	331.0	COG4251@1|root,COG4251@2|Bacteria,4NN2W@976|Bacteroidetes	976|Bacteroidetes	T	Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154,HATPase_c,HisKA
XH1_k127_328739_2	373994.Riv7116_4287	2.018e-50	183.0	COG0784@1|root,COG0784@2|Bacteria,1G6N0@1117|Cyanobacteria,1HP5R@1161|Nostocales	1117|Cyanobacteria	T	PFAM Signal transduction response regulator, receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
XH1_k127_328739_3	323259.Mhun_1208	1.521e-33	138.0	COG0642@1|root,arCOG02385@1|root,arCOG02385@2157|Archaea,arCOG06192@2157|Archaea	2157|Archaea	T	TIGRFAM PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_3,PAS_4,PAS_9,Response_reg
XH1_k127_3344403_0	573413.Spirs_3041	8.759e-59	218.0	COG1418@1|root,COG4905@1|root,COG1418@2|Bacteria,COG4905@2|Bacteria,2J7SH@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG4905 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
XH1_k127_3344403_1	909663.KI867150_gene1451	7.32e-40	151.0	COG0500@1|root,COG2226@2|Bacteria,1PEBD@1224|Proteobacteria,42T7H@68525|delta/epsilon subdivisions,2WPN7@28221|Deltaproteobacteria,2MQP2@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
XH1_k127_3356818_2	686340.Metal_0698	4.05e-30	123.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XF6T@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
XH1_k127_3356818_3	1507.HMPREF0262_01801	2.489e-13	71.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,36MNG@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
XH1_k127_3356818_1	856793.MICA_117	6.669e-42	162.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,4BQEB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
XH1_k127_3356818_0	1480694.DC28_03575	6.384e-121	396.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
XH1_k127_3368627_2	1120973.AQXL01000105_gene2571	7.499e-34	132.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,4HKEK@91061|Bacilli,27A2I@186823|Alicyclobacillaceae	91061|Bacilli	O	Chaperonin 10 Kd subunit	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
XH1_k127_3368627_0	639282.DEFDS_0466	1.397e-50	184.0	COG0315@1|root,COG0315@2|Bacteria,2GFIE@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
XH1_k127_3368627_1	1117379.BABA_19126	1.449e-34	141.0	COG1183@1|root,COG1183@2|Bacteria,1TR44@1239|Firmicutes,4HF0K@91061|Bacilli,1ZDC6@1386|Bacillus	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
XH1_k127_3377454_4	580327.Tthe_0532	2.966e-45	166.0	COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,24J8G@186801|Clostridia,42GHI@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
XH1_k127_3377454_6	1173028.ANKO01000167_gene1204	5.613e-08	62.0	COG4990@1|root,COG4990@2|Bacteria,1GHGJ@1117|Cyanobacteria,1HHUK@1150|Oscillatoriales	1117|Cyanobacteria	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
XH1_k127_3377454_3	929556.Solca_1355	1.586e-51	184.0	COG0662@1|root,COG0662@2|Bacteria,4NQIP@976|Bacteroidetes,1IZZH@117747|Sphingobacteriia	976|Bacteroidetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
XH1_k127_3377454_5	443143.GM18_3286	2.614e-32	130.0	COG5015@1|root,COG5015@2|Bacteria,1NXDP@1224|Proteobacteria,430B4@68525|delta/epsilon subdivisions,2WW5H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
XH1_k127_3377454_0	335992.SAR11_0205	1.269e-150	482.0	COG1899@1|root,COG1899@2|Bacteria,1MVC6@1224|Proteobacteria,2TTRW@28211|Alphaproteobacteria,4BRI5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
XH1_k127_3377454_1	391587.KAOT1_08533	2.006e-99	333.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,1HYIB@117743|Flavobacteriia	976|Bacteroidetes	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
XH1_k127_3377454_2	313606.M23134_04871	3.816e-63	223.0	COG1945@1|root,COG1945@2|Bacteria,4NKCB@976|Bacteroidetes	976|Bacteroidetes	S	arginine decarboxylase	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
XH1_k127_3386594_0	526224.Bmur_1068	1.537e-98	326.0	COG1077@1|root,COG1077@2|Bacteria,2J59M@203691|Spirochaetes	203691|Spirochaetes	D	cell shape determining protein, MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
XH1_k127_3405412_0	221027.JO40_05860	1.044e-81	280.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
XH1_k127_3405412_1	889378.Spiaf_2098	9.358e-21	99.0	COG1843@1|root,COG1843@2|Bacteria,2J806@203691|Spirochaetes	203691|Spirochaetes	N	flagellar hook	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
XH1_k127_3405412_2	1408322.JHYK01000007_gene2048	0.0003	53.0	COG3144@1|root,COG3144@2|Bacteria,1VAP1@1239|Firmicutes,24RF8@186801|Clostridia,27K29@186928|unclassified Lachnospiraceae	186801|Clostridia	N	Flagellar hook-length control protein FliK	fliK	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
XH1_k127_3445589_0	588581.Cpap_0661	2.918e-29	124.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia	186801|Clostridia	M	transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
XH1_k127_3445981_2	509191.AEDB02000088_gene2665	1.717e-10	63.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,3WGQA@541000|Ruminococcaceae	186801|Clostridia	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
XH1_k127_3445981_1	1265505.ATUG01000001_gene4010	1.28e-47	175.0	COG1433@1|root,COG1433@2|Bacteria,1N8RP@1224|Proteobacteria,42W3C@68525|delta/epsilon subdivisions,2WRJB@28221|Deltaproteobacteria,2MKUU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
XH1_k127_3445981_0	1304872.JAGC01000003_gene2882	1.851e-107	358.0	COG2199@1|root,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,42NGW@68525|delta/epsilon subdivisions,2WKG6@28221|Deltaproteobacteria,2M8K8@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
XH1_k127_3449868_1	65393.PCC7424_1391	0.0007477	48.0	COG1413@1|root,COG1413@2|Bacteria,1G528@1117|Cyanobacteria,3KHZP@43988|Cyanothece	1117|Cyanobacteria	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
XH1_k127_3449868_0	237368.SCABRO_02639	3.056e-187	600.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2IYK8@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
XH1_k127_3462058_1	903818.KI912269_gene423	1.808e-50	181.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9,Flavodoxin_5
XH1_k127_3462058_0	269799.Gmet_2999	2.161e-131	428.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42M4Y@68525|delta/epsilon subdivisions,2WKKD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
XH1_k127_3462058_2	1121335.Clst_2614	7.366e-25	105.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia,3WJDT@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the LDH2 MDH2 oxidoreductase family	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
XH1_k127_3483959_0	557598.LHK_03176	6.15e-42	157.0	COG0824@1|root,COG0824@2|Bacteria,1REIH@1224|Proteobacteria,2VTNS@28216|Betaproteobacteria,2KRST@206351|Neisseriales	206351|Neisseriales	S	Acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K12500	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	4HBT,4HBT_2
XH1_k127_3490567_3	500633.CLOHIR_02130	1.128e-21	101.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,25RQP@186804|Peptostreptococcaceae	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
XH1_k127_3490567_4	1121396.KB893079_gene810	7.066e-05	54.0	COG4241@1|root,COG4241@2|Bacteria,1N4XJ@1224|Proteobacteria,42QCS@68525|delta/epsilon subdivisions,2WKDT@28221|Deltaproteobacteria,2MIFQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
XH1_k127_3490567_2	1123376.AUIU01000011_gene1050	1.839e-36	142.0	COG0359@1|root,COG0359@2|Bacteria,3J0MQ@40117|Nitrospirae	40117|Nitrospirae	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
XH1_k127_3490567_0	868595.Desca_2719	6.296e-125	414.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,260E3@186807|Peptococcaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
XH1_k127_3490567_1	1045858.Bint_1155	7.909e-62	221.0	COG0767@1|root,COG0767@2|Bacteria,2J7HE@203691|Spirochaetes	203691|Spirochaetes	Q	Belongs to the MlaE permease family	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
XH1_k127_3556622_2	1265505.ATUG01000002_gene2495	7.364e-57	206.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,2MM84@213118|Desulfobacterales	28221|Deltaproteobacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
XH1_k127_3556622_1	909663.KI867150_gene1537	1.094e-108	355.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,42N6T@68525|delta/epsilon subdivisions,2WMKR@28221|Deltaproteobacteria,2MQC8@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
XH1_k127_3556622_0	56780.SYN_00839	2.387e-111	367.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42S6I@68525|delta/epsilon subdivisions,2WNNW@28221|Deltaproteobacteria,2MQGT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.29,3.6.3.55	ko:K02017,ko:K06857	ko02010,map02010	M00186,M00189	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4,3.A.1.8	-	-	ABC_tran,TOBE
XH1_k127_356264_0	1499967.BAYZ01000195_gene3095	3.558e-48	192.0	COG0457@1|root,COG0457@2|Bacteria,2NPEN@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
XH1_k127_3584474_2	388051.AUFE01000007_gene1413	2.572e-13	79.0	COG2362@1|root,COG2362@2|Bacteria,1QH4F@1224|Proteobacteria,2VJ5K@28216|Betaproteobacteria,1K1NV@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM peptidase M55 D-aminopeptidase	dppA1a	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
XH1_k127_3584474_0	909663.KI867150_gene2459	7.409e-38	143.0	2AJ37@1|root,319MK@2|Bacteria,1Q37E@1224|Proteobacteria,42WW2@68525|delta/epsilon subdivisions,2WSSN@28221|Deltaproteobacteria,2MRXB@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_3584474_1	933262.AXAM01000016_gene150	1.49e-36	140.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42MFD@68525|delta/epsilon subdivisions,2WJCZ@28221|Deltaproteobacteria,2MI2F@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
XH1_k127_3585837_1	1125863.JAFN01000001_gene2024	1.971e-06	57.0	COG3149@1|root,COG3149@2|Bacteria,1NEZ3@1224|Proteobacteria,42WMP@68525|delta/epsilon subdivisions,2WSE1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein M	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
XH1_k127_3585837_0	1121405.dsmv_2328	1.998e-14	86.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
XH1_k127_3594040_2	398767.Glov_0749	1.091e-05	57.0	COG1538@1|root,COG1538@2|Bacteria,1R705@1224|Proteobacteria,42V98@68525|delta/epsilon subdivisions,2WRX2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
XH1_k127_3594040_1	1121423.JONT01000017_gene113	1.684e-14	83.0	COG1309@1|root,COG1309@2|Bacteria,1V86J@1239|Firmicutes,24UGC@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_9,TetR_N
XH1_k127_3594040_0	304371.MCP_1842	1.715e-24	109.0	COG0454@1|root,arCOG00826@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_9
XH1_k127_3600386_1	56780.SYN_01811	1.436e-66	233.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,43AEG@68525|delta/epsilon subdivisions,2X5U9@28221|Deltaproteobacteria,2MQZT@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
XH1_k127_3600386_2	56780.SYN_03783	4.406e-33	132.0	2FA5F@1|root,33ZQN@2|Bacteria,1NXGX@1224|Proteobacteria,430AQ@68525|delta/epsilon subdivisions,2WW50@28221|Deltaproteobacteria,2MS2H@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_3600386_0	1121405.dsmv_3739	2.296e-142	462.0	COG0006@1|root,COG0006@2|Bacteria,1MVJK@1224|Proteobacteria,43DQS@68525|delta/epsilon subdivisions,2X6WA@28221|Deltaproteobacteria,2MID9@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
XH1_k127_3696207_2	1394178.AWOO02000055_gene827	2.284e-10	66.0	292KZ@1|root,2ZQ4W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_3696207_0	720555.BATR1942_12250	7.296e-48	181.0	COG1011@1|root,COG1011@2|Bacteria,1TS3W@1239|Firmicutes,4HADE@91061|Bacilli,1ZBN8@1386|Bacillus	91061|Bacilli	S	HAD-hyrolase-like	ysaA	-	3.1.3.5,3.8.1.2	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287	RC00017,RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
XH1_k127_3696207_1	1379698.RBG1_1C00001G1090	8.392e-28	115.0	COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
XH1_k127_3708933_0	744872.Spica_2840	1.889e-220	696.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
XH1_k127_3716705_0	1121405.dsmv_1647	1.155e-206	660.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MIAK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578,ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
XH1_k127_3726727_1	926692.AZYG01000079_gene357	1.205e-27	117.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1UI8N@1239|Firmicutes,25EE0@186801|Clostridia,3WASU@53433|Halanaerobiales	186801|Clostridia	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,GGDEF
XH1_k127_3726727_0	1168034.FH5T_11385	8.835e-80	276.0	COG0196@1|root,COG0196@2|Bacteria,4NEI9@976|Bacteroidetes,2FM7A@200643|Bacteroidia	976|Bacteroidetes	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
XH1_k127_3738113_1	1307759.JOMJ01000004_gene2895	1.645e-36	141.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,42SAN@68525|delta/epsilon subdivisions,2WP1V@28221|Deltaproteobacteria,2MBYS@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Ribose galactose isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1604	LacAB_rpiB
XH1_k127_3738113_0	439481.Aboo_1543	3.981e-96	326.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,3F36H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
XH1_k127_3738113_2	1121289.JHVL01000059_gene2515	1.569e-08	56.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,36DE7@31979|Clostridiaceae	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
XH1_k127_3754692_0	41431.PCC8801_0698	7.343e-09	69.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,3KJZE@43988|Cyanothece	1117|Cyanobacteria	O	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
XH1_k127_3782463_0	909663.KI867150_gene1458	9.572e-166	524.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
XH1_k127_3782463_1	237368.SCABRO_01504	2.869e-153	499.0	COG0659@1|root,COG0659@2|Bacteria,2IX8K@203682|Planctomycetes	203682|Planctomycetes	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	-
XH1_k127_3782463_2	1322246.BN4_12561	3.942e-52	186.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2WP2B@28221|Deltaproteobacteria,2MBKZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1897	PRA-CH,PRA-PH
XH1_k127_3782463_3	443144.GM21_0740	2.166e-14	73.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
XH1_k127_3782906_3	1184267.A11Q_2352	1.305e-08	59.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria,42P74@68525|delta/epsilon subdivisions,2MU67@213481|Bdellovibrionales,2WK88@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
XH1_k127_3782906_2	306263.Cla_0303	2.1e-47	178.0	COG0584@1|root,COG0584@2|Bacteria,1RJ9Y@1224|Proteobacteria,42QUS@68525|delta/epsilon subdivisions,2YP0G@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_3782906_1	306264.CUP1140	5.249e-63	224.0	COG0637@1|root,COG0637@2|Bacteria,1RC0Z@1224|Proteobacteria,42Q7Y@68525|delta/epsilon subdivisions,2YTRK@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
XH1_k127_3782906_0	93060.P9215_14211	3.745e-75	259.0	COG0637@1|root,COG1209@1|root,COG0637@2|Bacteria,COG1209@2|Bacteria	2|Bacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,NTP_transf_3,NTP_transferase
XH1_k127_3798969_0	457570.Nther_0100	1.228e-73	265.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia	186801|Clostridia	C	Molybdopterin oxidoreductase, Fe4S4	-	-	1.17.1.10	ko:K05299	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
XH1_k127_3798969_1	338966.Ppro_2789	6.52e-33	136.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,43VYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
XH1_k127_3808043_0	1232410.KI421413_gene663	4.779e-78	276.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,43SAV@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Bacterial DNA polymerase III alpha subunit	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
XH1_k127_3808043_2	545694.TREPR_2028	1.664e-21	107.0	COG0389@1|root,COG0389@2|Bacteria,2J5SS@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS
XH1_k127_3808043_1	335543.Sfum_0927	8.39e-52	189.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42PAH@68525|delta/epsilon subdivisions,2WKSM@28221|Deltaproteobacteria,2MS4X@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356,ko:K03503	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
XH1_k127_3808043_3	889378.Spiaf_0158	5.371e-18	88.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
XH1_k127_3808116_4	59374.Fisuc_0857	5.936e-20	93.0	COG0598@1|root,COG0598@2|Bacteria	2|Bacteria	P	Magnesium transport protein CorA	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
XH1_k127_3808116_5	316067.Geob_2023	6.424e-14	77.0	2DPPJ@1|root,332WE@2|Bacteria,1NMBJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_3808116_1	700598.Niako_1817	2.031e-33	131.0	COG0389@1|root,COG0389@2|Bacteria,4NUAB@976|Bacteroidetes	976|Bacteroidetes	L	Pathogenicity locus	-	-	-	-	-	-	-	-	-	-	-	-	Cdd1
XH1_k127_3808116_0	484770.UFO1_1587	9.048e-56	205.0	COG4927@1|root,COG4927@2|Bacteria	2|Bacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
XH1_k127_3808116_2	868131.MSWAN_0546	3.836e-32	134.0	COG0500@1|root,arCOG02702@2157|Archaea,2XWS9@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
XH1_k127_3808116_3	526227.Mesil_0168	3.253e-31	130.0	COG4635@1|root,COG4635@2|Bacteria	2|Bacteria	CH	menaquinone-dependent protoporphyrinogen oxidase activity	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
XH1_k127_381056_0	1131269.AQVV01000018_gene1926	5.068e-160	515.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
XH1_k127_381056_1	443143.GM18_4377	9.284e-99	339.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
XH1_k127_3821056_1	941824.TCEL_00444	1.983e-32	131.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
XH1_k127_3821056_0	744872.Spica_0062	2.28e-135	454.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,2JAHT@203691|Spirochaetes	203691|Spirochaetes	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
XH1_k127_3843322_0	439235.Dalk_4850	3.083e-315	994.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
XH1_k127_3844471_0	1167006.UWK_01019	2.692e-64	231.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MIED@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
XH1_k127_3844471_1	443144.GM21_3963	2.328e-14	78.0	COG0348@1|root,COG1143@1|root,COG1245@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1245@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
XH1_k127_3882642_2	56780.SYN_02871	7.379e-68	232.0	COG0599@1|root,COG0599@2|Bacteria,1Q5KF@1224|Proteobacteria,42SAS@68525|delta/epsilon subdivisions,2WP9N@28221|Deltaproteobacteria,2MRQK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
XH1_k127_3882642_0	909663.KI867150_gene2405	1.049e-164	524.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2MREJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
XH1_k127_3882642_1	1121405.dsmv_2383	2.02e-117	398.0	COG1001@1|root,COG1001@2|Bacteria,1MVFP@1224|Proteobacteria,42NWX@68525|delta/epsilon subdivisions,2WIZY@28221|Deltaproteobacteria,2MIYG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Adenine deaminase C-terminal domain	-	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
XH1_k127_3882642_3	1120998.AUFC01000024_gene2450	2.962e-38	146.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,3WCUD@538999|Clostridiales incertae sedis	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
XH1_k127_3886631_6	555779.Dthio_PD3020	2.057e-14	73.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,42RGG@68525|delta/epsilon subdivisions,2X6F1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
XH1_k127_3886631_4	933262.AXAM01000022_gene3236	2.62e-45	167.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria,2MKQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
XH1_k127_3886631_1	1157490.EL26_16220	1.893e-79	271.0	COG0684@1|root,COG0684@2|Bacteria,1W795@1239|Firmicutes,4HSY7@91061|Bacilli,27AKQ@186823|Alicyclobacillaceae	91061|Bacilli	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
XH1_k127_3886631_0	706587.Desti_4490	1.774e-95	318.0	COG2220@1|root,COG2220@2|Bacteria,1QB9E@1224|Proteobacteria,42N7W@68525|delta/epsilon subdivisions,2WMED@28221|Deltaproteobacteria,2MQU6@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
XH1_k127_3886631_3	1089553.Tph_c22540	5.069e-65	228.0	COG2102@1|root,COG2102@2|Bacteria,1UAKZ@1239|Firmicutes,24C6P@186801|Clostridia	186801|Clostridia	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
XH1_k127_3886631_2	690850.Desaf_2915	3.458e-79	287.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WKBG@28221|Deltaproteobacteria,2M7VH@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	PFAM cytochrome c biogenesis protein transmembrane region	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
XH1_k127_3886631_5	760011.Spico_0116	3.031e-17	85.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
XH1_k127_388849_2	335543.Sfum_4099	1.001e-32	130.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MQCI@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
XH1_k127_388849_1	1123371.ATXH01000023_gene935	1.562e-88	301.0	COG1410@1|root,COG1410@2|Bacteria,2GH4X@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Pterin binding enzyme	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
XH1_k127_388849_0	589865.DaAHT2_0824	1.507e-182	581.0	COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MI7W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
XH1_k127_3931878_0	632245.CLP_2881	5.012e-11	76.0	COG3027@1|root,COG3027@2|Bacteria,1VIXT@1239|Firmicutes,24RYN@186801|Clostridia,36ISE@31979|Clostridiaceae	186801|Clostridia	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
XH1_k127_3938643_2	370438.PTH_1872	3.606e-20	92.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,266SD@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
XH1_k127_3938643_1	694431.DESACE_02090	9.513e-31	131.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2M71J@213113|Desulfurellales	28221|Deltaproteobacteria	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
XH1_k127_3938643_0	335543.Sfum_1335	2.167e-61	223.0	2CIBN@1|root,2Z8JT@2|Bacteria,1QGIJ@1224|Proteobacteria,42S2V@68525|delta/epsilon subdivisions,2WNZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_3965163_0	237368.SCABRO_03770	5.541e-90	310.0	COG0787@1|root,COG0787@2|Bacteria,2IZJH@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
XH1_k127_3965163_1	573413.Spirs_1013	1.541e-59	217.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
XH1_k127_3965163_2	500633.CLOHIR_01461	3.097e-11	67.0	COG1652@1|root,COG1652@2|Bacteria,1V1BA@1239|Firmicutes,24REC@186801|Clostridia,25U0V@186804|Peptostreptococcaceae	186801|Clostridia	S	LysM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM
XH1_k127_3996509_0	1499967.BAYZ01000103_gene3740	1.125e-173	552.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
XH1_k127_3996509_1	1499967.BAYZ01000103_gene3739	1.822e-24	105.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE,TusA
XH1_k127_4010245_1	1173026.Glo7428_0852	1.945e-06	59.0	COG3712@1|root,COG5164@1|root,COG3712@2|Bacteria,COG5164@2|Bacteria,1FZWC@1117|Cyanobacteria	1117|Cyanobacteria	PT	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
XH1_k127_4010245_0	522306.CAP2UW1_4245	3.035e-19	96.0	COG0517@1|root,COG0517@2|Bacteria,1RE9W@1224|Proteobacteria,2VSNZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
XH1_k127_401519_1	403833.Pmob_1207	7.001e-26	111.0	COG0159@1|root,COG0159@2|Bacteria,2GE4K@200918|Thermotogae	200918|Thermotogae	F	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
XH1_k127_401519_0	485913.Krac_0700	2.086e-89	306.0	COG0002@1|root,COG0002@2|Bacteria,2G6D0@200795|Chloroflexi	2|Bacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190	Semialdhyde_dh,Semialdhyde_dhC
XH1_k127_4042769_0	857293.CAAU_0197	7.524e-77	266.0	COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,36EWE@31979|Clostridiaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
XH1_k127_4057216_1	471854.Dfer_3799	1.933e-37	147.0	28N6F@1|root,2ZBBB@2|Bacteria,4NGM1@976|Bacteroidetes,47P0U@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_4057216_0	1121403.AUCV01000013_gene3899	2.23e-51	185.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	transcriptional regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
XH1_k127_4057216_2	909663.KI867150_gene302	7.193e-33	133.0	COG2067@1|root,COG2067@2|Bacteria,1N1F4@1224|Proteobacteria,42ZP2@68525|delta/epsilon subdivisions,2WUUM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
XH1_k127_4057664_0	573413.Spirs_2426	6.032e-107	361.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
XH1_k127_4073929_0	880073.Calab_2574	2.446e-168	534.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
XH1_k127_4073929_1	324925.Ppha_0637	1.709e-07	61.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1FDGV@1090|Chlorobi	2|Bacteria	H	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
XH1_k127_4074648_1	909663.KI867150_gene1540	1.018e-69	241.0	COG0006@1|root,COG0006@2|Bacteria,1MVJK@1224|Proteobacteria,43DQS@68525|delta/epsilon subdivisions,2X6WA@28221|Deltaproteobacteria,2MR15@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
XH1_k127_4074648_0	70601.3257173	6.462e-133	438.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,243RU@183968|Thermococci	183968|Thermococci	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
XH1_k127_4075715_0	316067.Geob_0573	3.743e-197	622.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,42MGH@68525|delta/epsilon subdivisions,2WK72@28221|Deltaproteobacteria,43S83@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon_1	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
XH1_k127_4075715_1	429009.Adeg_1948	7.834e-42	161.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
XH1_k127_4123405_0	338966.Ppro_2786	1.563e-80	276.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	hycE	GO:0003674,GO:0005488,GO:0016151,GO:0043167,GO:0043169,GO:0046872,GO:0046914	1.6.5.3	ko:K00333,ko:K12142,ko:K15830	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iECED1_1282.ECED1_3172,iEcE24377_1341.EcE24377A_2769,iYL1228.KPN_03058	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
XH1_k127_4123405_1	338966.Ppro_2785	2.944e-58	212.0	COG0650@1|root,COG0650@2|Bacteria,1QUK1@1224|Proteobacteria,42PHN@68525|delta/epsilon subdivisions,2WKPJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM respiratory-chain NADH dehydrogenase, subunit 1	-	-	-	ko:K14087	-	-	-	-	ko00000	-	-	-	NADHdh
XH1_k127_4155155_1	568816.Acin_1489	1.99e-83	285.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4H1Z6@909932|Negativicutes	909932|Negativicutes	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
XH1_k127_4155155_2	1408422.JHYF01000009_gene2078	3.368e-56	203.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,36I69@31979|Clostridiaceae	186801|Clostridia	O	anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
XH1_k127_4155155_3	1123371.ATXH01000015_gene1650	2.09e-11	65.0	COG1328@1|root,COG1328@2|Bacteria,2GI4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	NRDD
XH1_k127_4155155_0	161156.JQKW01000009_gene1628	2.818e-282	877.0	COG1328@1|root,COG1328@2|Bacteria,2GH9B@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	ATP cone domain	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,NRDD
XH1_k127_4157268_1	370438.PTH_1020	1.591e-150	486.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,2601M@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
XH1_k127_4157268_2	374847.Kcr_0658	4.675e-107	356.0	COG2358@1|root,arCOG01801@2157|Archaea	2157|Archaea	S	TRAP transporter solute receptor, TAXI family	imp	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
XH1_k127_4157268_0	374847.Kcr_0659	1.056e-175	564.0	COG4666@1|root,arCOG01906@2157|Archaea	2157|Archaea	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
XH1_k127_418264_0	767817.Desgi_4664	1.003e-238	744.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,2607A@186807|Peptococcaceae	186801|Clostridia	J	PFAM tRNA synthetases class I (E and Q), catalytic domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
XH1_k127_418264_1	1191523.MROS_1120	7.645e-115	381.0	COG1408@1|root,COG1408@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	Z012_05430	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
XH1_k127_418264_2	314230.DSM3645_16200	1.441e-14	83.0	COG1305@1|root,COG1305@2|Bacteria,2IYTT@203682|Planctomycetes	203682|Planctomycetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
XH1_k127_418264_3	312309.VF_0705	1.642e-08	58.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1XTKW@135623|Vibrionales	135623|Vibrionales	F	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
XH1_k127_4207839_1	880073.Calab_1429	1.283e-47	174.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.12.1.4,1.6.5.3	ko:K00334,ko:K17999	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
XH1_k127_4207839_0	880073.Calab_1430	1.776e-50	186.0	COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
XH1_k127_4207839_2	945713.IALB_0315	2.435e-41	159.0	COG0632@1|root,COG0632@2|Bacteria	2|Bacteria	L	four-way junction helicase activity	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
XH1_k127_4207839_3	632292.Calhy_1620	5.534e-30	121.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,42GAQ@68295|Thermoanaerobacterales	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
XH1_k127_4228045_2	289376.THEYE_A1426	4.744e-73	254.0	COG0024@1|root,COG0024@2|Bacteria,3J0GR@40117|Nitrospirae	40117|Nitrospirae	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
XH1_k127_4228045_1	1304284.L21TH_0691	1.775e-149	480.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
XH1_k127_4228045_0	56780.SYN_00090	1.43e-180	580.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MQXU@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
XH1_k127_4228045_3	1267533.KB906733_gene3438	9.761e-10	65.0	COG1595@1|root,COG1595@2|Bacteria,3Y8V2@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
XH1_k127_4231688_3	1131462.DCF50_p2402	4.905e-13	70.0	COG2378@1|root,COG2378@2|Bacteria,1TS78@1239|Firmicutes,25C7I@186801|Clostridia,261PK@186807|Peptococcaceae	186801|Clostridia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
XH1_k127_4231688_1	1122931.AUAE01000014_gene1915	1.136e-32	130.0	2C0TM@1|root,32UWC@2|Bacteria,4NSYE@976|Bacteroidetes,2FTDD@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
XH1_k127_4231688_2	1343739.PAP_07545	6.258e-18	87.0	arCOG06793@1|root,arCOG06793@2157|Archaea,2Y533@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_4231688_0	1541960.KQ78_01052	3.774e-34	139.0	COG2342@1|root,COG2342@2|Bacteria	2|Bacteria	G	Glycoside-hydrolase family GH114	-	-	6.1.1.16	ko:K01884	ko00970,map00970	M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iLJ478.TM1410	GH114_assoc,Glyco_hydro_114
XH1_k127_423988_1	909663.KI867150_gene342	6.207e-77	262.0	COG1139@1|root,COG1139@2|Bacteria,1QX2J@1224|Proteobacteria,42M6G@68525|delta/epsilon subdivisions,2WJJC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
XH1_k127_423988_0	909663.KI867150_gene343	3.538e-138	445.0	COG0479@1|root,COG1035@1|root,COG0479@2|Bacteria,COG1035@2|Bacteria,1NQN7@1224|Proteobacteria,42MGI@68525|delta/epsilon subdivisions,2WKNC@28221|Deltaproteobacteria,2MRN3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hdrD	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_17,Fer4_8,FlpD,FrhB_FdhB_C
XH1_k127_423988_2	909663.KI867150_gene344	6.144e-76	255.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria,2MRBM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase, delta subunit	hdrG	-	-	-	-	-	-	-	-	-	-	-	FlpD
XH1_k127_4254991_2	632518.Calow_1331	1.653e-27	114.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,42F85@68295|Thermoanaerobacterales	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
XH1_k127_4254991_1	1307761.L21SP2_1148	3.244e-36	147.0	2E1YA@1|root,32X70@2|Bacteria,2J5Q9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_4254991_0	515635.Dtur_1233	1.138e-108	367.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
XH1_k127_4265896_1	273068.TTE1538	3.258e-89	304.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,42F72@68295|Thermoanaerobacterales	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
XH1_k127_4265896_3	639030.JHVA01000001_gene652	1.012e-21	99.0	COG2050@1|root,COG2050@2|Bacteria,3Y57I@57723|Acidobacteria,2JJU4@204432|Acidobacteriia	204432|Acidobacteriia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
XH1_k127_4265896_0	706587.Desti_1431	7.733e-142	466.0	COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
XH1_k127_4265896_2	436114.SYO3AOP1_1582	8.018e-27	112.0	COG0289@1|root,COG0289@2|Bacteria,2G3YB@200783|Aquificae	200783|Aquificae	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
XH1_k127_4282422_0	909663.KI867149_gene3194	1.908e-42	163.0	COG0775@1|root,COG0775@2|Bacteria	2|Bacteria	F	adenosylhomocysteine nucleosidase activity	pfs	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
XH1_k127_4282422_1	938278.CAJO01000068_gene930	6.228e-08	54.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,26955@186813|unclassified Clostridiales	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
XH1_k127_4284179_2	1123058.KB894223_gene828	1.971e-16	82.0	COG0469@1|root,COG0469@2|Bacteria,4NEEU@976|Bacteroidetes,1HX84@117743|Flavobacteriia	976|Bacteroidetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
XH1_k127_4284179_0	709991.Odosp_0438	2.894e-56	204.0	COG2173@1|root,COG2173@2|Bacteria,4NE2K@976|Bacteroidetes,2FPAB@200643|Bacteroidia,22Y2H@171551|Porphyromonadaceae	976|Bacteroidetes	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
XH1_k127_4284179_1	497964.CfE428DRAFT_0539	4.45e-20	93.0	COG1403@1|root,COG1403@2|Bacteria,46SMP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	HNH endonuclease	mcrA	-	-	-	-	-	-	-	-	-	-	-	HNH_5
XH1_k127_4296253_2	1121403.AUCV01000022_gene3495	3.252e-24	105.0	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,42NYN@68525|delta/epsilon subdivisions,2WJFE@28221|Deltaproteobacteria,2MHZZ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
XH1_k127_4296253_1	882.DVU_1534	1.285e-36	143.0	COG2391@1|root,COG2391@2|Bacteria,1RDQK@1224|Proteobacteria,42RU6@68525|delta/epsilon subdivisions,2WNJT@28221|Deltaproteobacteria,2MBSU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
XH1_k127_4296253_3	927658.AJUM01000022_gene1088	8.948e-07	51.0	COG2391@1|root,COG2391@2|Bacteria,4PJMC@976|Bacteroidetes,2FZGI@200643|Bacteroidia	976|Bacteroidetes	S	Sulphur transport	-	-	-	-	-	-	-	-	-	-	-	-	Sulf_transp
XH1_k127_4296253_0	880072.Desac_2060	7.042e-47	177.0	COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MRP5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
XH1_k127_4324063_0	56780.SYN_01009	0.0	1075.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MR2C@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
XH1_k127_4324063_1	56780.SYN_02386	6.988e-23	100.0	COG3809@1|root,COG3809@2|Bacteria,1N6ZY@1224|Proteobacteria,42VNA@68525|delta/epsilon subdivisions,2WRKK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
XH1_k127_4327392_0	243231.GSU3251	3.109e-39	149.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
XH1_k127_4327392_1	1232437.KL662036_gene2712	2.07e-18	90.0	COG0748@1|root,COG0748@2|Bacteria,1N6EJ@1224|Proteobacteria,42W5F@68525|delta/epsilon subdivisions,2WRHB@28221|Deltaproteobacteria,2MKR5@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
XH1_k127_4331582_0	1480694.DC28_00090	4.556e-179	583.0	COG0480@1|root,COG0480@2|Bacteria,2J5YJ@203691|Spirochaetes	203691|Spirochaetes	J	translation elongation factor	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
XH1_k127_4370917_1	909663.KI867149_gene3189	2.292e-117	381.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MRA9@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
XH1_k127_4370917_0	909663.KI867149_gene3190	3.286e-282	874.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42PXA@68525|delta/epsilon subdivisions,2WM6E@28221|Deltaproteobacteria,2MRCU@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
XH1_k127_4380037_2	985665.HPL003_10245	1.14e-31	127.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,4HKEF@91061|Bacilli,26YJV@186822|Paenibacillaceae	91061|Bacilli	J	endoribonuclease L-PSP	yhaR	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
XH1_k127_4380037_0	935948.KE386494_gene477	1.733e-131	429.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,42FZM@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Cys Met metabolism	metC	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
XH1_k127_4380037_1	1122947.FR7_2747	2.84e-67	238.0	COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,4H2JQ@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
XH1_k127_444516_3	1121441.AUCX01000005_gene1394	2.204e-53	204.0	COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,43ADW@68525|delta/epsilon subdivisions,2X5TV@28221|Deltaproteobacteria,2MGVZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
XH1_k127_444516_0	289376.THEYE_A0033	3.941e-153	505.0	COG2905@1|root,COG2905@2|Bacteria,3J0UW@40117|Nitrospirae	40117|Nitrospirae	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
XH1_k127_444516_4	706587.Desti_2342	6.61e-36	146.0	COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,43AQH@68525|delta/epsilon subdivisions,2X64E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
XH1_k127_444516_1	1449126.JQKL01000034_gene1279	2.778e-150	486.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,26A76@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
XH1_k127_444516_2	313628.LNTAR_00085	1.907e-90	301.0	COG0379@1|root,COG0379@2|Bacteria	2|Bacteria	H	quinolinate synthetase A activity	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iHN637.CLJU_RS12020,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919	NadA
XH1_k127_4486440_1	644282.Deba_1109	1.231e-42	161.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42S0M@68525|delta/epsilon subdivisions,2WNYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	yheT	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6
XH1_k127_4486440_0	933262.AXAM01000037_gene878	4.079e-132	434.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MN6X@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
XH1_k127_4498132_0	935836.JAEL01000017_gene810	0.0001799	49.0	2EDMZ@1|root,337HS@2|Bacteria,1VPSQ@1239|Firmicutes,4HRHN@91061|Bacilli,1ZB19@1386|Bacillus	91061|Bacilli	S	YtkA-like	-	-	-	-	-	-	-	-	-	-	-	-	YtkA
XH1_k127_4537571_0	56780.SYN_02383	2.881e-302	947.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MR7X@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
XH1_k127_4542436_0	926569.ANT_09020	8.682e-122	402.0	COG0477@1|root,COG2814@2|Bacteria,2G8W5@200795|Chloroflexi	200795|Chloroflexi	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
XH1_k127_4568641_0	1121012.AUKX01000004_gene3525	2.591e-07	62.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1HWWK@117743|Flavobacteriia,23G4M@178469|Arenibacter	976|Bacteroidetes	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
XH1_k127_4639351_1	1121405.dsmv_0189	2.844e-104	344.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MI5@68525|delta/epsilon subdivisions,2WITQ@28221|Deltaproteobacteria,2MI9V@213118|Desulfobacterales	28221|Deltaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
XH1_k127_4639351_0	1121405.dsmv_0188	1.873e-160	514.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42M0D@68525|delta/epsilon subdivisions,2WK8T@28221|Deltaproteobacteria,2MJ65@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
XH1_k127_4639351_2	1469245.JFBG01000091_gene1645	1.602e-95	322.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales	135613|Chromatiales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
XH1_k127_4639351_3	697281.Mahau_2272	1.161e-59	219.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,42F07@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Capsule synthesis protein, CapA	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,Peptidase_M15
XH1_k127_4754386_2	1267533.KB906740_gene155	4.237e-11	65.0	COG1309@1|root,COG1309@2|Bacteria,3Y8NY@57723|Acidobacteria,2JNEU@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
XH1_k127_4754386_0	573413.Spirs_3800	1.415e-151	496.0	COG0513@1|root,COG0513@2|Bacteria,2J5U7@203691|Spirochaetes	203691|Spirochaetes	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
XH1_k127_4754386_1	439235.Dalk_4371	9.446e-18	85.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MJA2@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
XH1_k127_4774534_1	443144.GM21_4075	0.0002234	50.0	COG2214@1|root,COG2214@2|Bacteria,1QXNV@1224|Proteobacteria,43CTH@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	SMART heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
XH1_k127_4774534_0	759914.BP951000_1815	1.727e-24	111.0	2C2MH@1|root,33D2Y@2|Bacteria,2J70Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_4791116_2	941824.TCEL_01381	1.22e-17	92.0	COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,36EQD@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Alpha-amylase,Alpha-amylase_N,Big_2,CBM_20,CBM_48,Cadherin-like,Malt_amylase_C,PUD,SLH
XH1_k127_4791116_1	1034347.CAHJ01000062_gene1019	2.447e-46	172.0	COG1522@1|root,COG1522@2|Bacteria,1V3PB@1239|Firmicutes,4HH9K@91061|Bacilli,1ZFM5@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	alaR	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
XH1_k127_4791116_0	439235.Dalk_1934	4.673e-78	263.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2MI0G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
XH1_k127_4830633_2	1125863.JAFN01000001_gene20	1.374e-08	62.0	COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
XH1_k127_4830633_1	1125863.JAFN01000001_gene19	4.366e-12	74.0	COG2770@1|root,COG2770@2|Bacteria,1R08R@1224|Proteobacteria,43CRE@68525|delta/epsilon subdivisions,2X7Z3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_4830633_0	1235793.C809_00622	9.52e-22	102.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,27IWC@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
XH1_k127_4852920_0	945713.IALB_2984	9.944e-82	274.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
XH1_k127_4852920_1	386456.JQKN01000008_gene1461	3.05e-67	236.0	arCOG03165@1|root,arCOG03165@2157|Archaea,2XXAZ@28890|Euryarchaeota,23PM9@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_4855547_2	1499967.BAYZ01000065_gene6104	9.066e-18	93.0	COG1544@1|root,COG1544@2|Bacteria,2NPYS@2323|unclassified Bacteria	2|Bacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
XH1_k127_4855547_1	264462.Bd0843	1.719e-86	304.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2MSR3@213481|Bdellovibrionales,2WJ21@28221|Deltaproteobacteria	213481|Bdellovibrionales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
XH1_k127_4855547_0	190304.FN0695	4.645e-92	308.0	COG1137@1|root,COG1137@2|Bacteria,379CC@32066|Fusobacteria	32066|Fusobacteria	S	K06861 lipopolysaccharide export system ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
XH1_k127_4855547_4	906968.Trebr_0877	3.369e-11	75.0	COG1934@1|root,COG1934@2|Bacteria,2J7U8@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
XH1_k127_4855547_5	1379698.RBG1_1C00001G0548	4.91e-09	64.0	COG3117@1|root,COG3117@2|Bacteria,2NQ8Q@2323|unclassified Bacteria	2|Bacteria	S	Lipopolysaccharide-assembly, LptC-related	lptC	-	-	ko:K09774,ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
XH1_k127_4855547_3	312309.VF_0176	1.463e-16	80.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1XVEC@135623|Vibrionales	135623|Vibrionales	M	DAHP synthetase I family	-	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
XH1_k127_487232_2	1121451.DESAM_21836	6.852e-48	188.0	COG4267@1|root,COG4267@2|Bacteria,1MUQN@1224|Proteobacteria,42Q3G@68525|delta/epsilon subdivisions,2WKR6@28221|Deltaproteobacteria,2MAM4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative exopolysaccharide Exporter (EPS-E)	-	-	-	ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	PelG
XH1_k127_487232_0	1121447.JONL01000009_gene2651	9.52e-104	354.0	COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,42Q1K@68525|delta/epsilon subdivisions,2WJ1U@28221|Deltaproteobacteria,2M8XU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glycos_transf_1
XH1_k127_487232_1	1121451.DESAM_21836	8.623e-70	253.0	COG4267@1|root,COG4267@2|Bacteria,1MUQN@1224|Proteobacteria,42Q3G@68525|delta/epsilon subdivisions,2WKR6@28221|Deltaproteobacteria,2MAM4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative exopolysaccharide Exporter (EPS-E)	-	-	-	ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	PelG
XH1_k127_487232_3	525897.Dbac_1382	2.132e-11	74.0	COG0745@1|root,COG1639@1|root,COG4191@1|root,COG0745@2|Bacteria,COG1639@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42Q3F@68525|delta/epsilon subdivisions,2WM2F@28221|Deltaproteobacteria,2MAB3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein, response regulator receiver, histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HDOD,HisKA,Response_reg
XH1_k127_4878262_0	760011.Spico_0629	3.079e-76	269.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
XH1_k127_4878262_1	622312.ROSEINA2194_03842	0.0002462	50.0	2E11F@1|root,32WHB@2|Bacteria,1VD34@1239|Firmicutes,24NEB@186801|Clostridia	186801|Clostridia	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
XH1_k127_4878642_0	237368.SCABRO_00905	6.692e-49	191.0	COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
XH1_k127_4879983_2	439235.Dalk_4428	6.289e-87	297.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MIPS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
XH1_k127_4879983_3	96561.Dole_2003	5.103e-86	298.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MIPS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
XH1_k127_4879983_0	1167006.UWK_00502	4.64e-296	918.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2MI51@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1259	ILVD_EDD
XH1_k127_4879983_6	536233.CLO_3249	2.734e-25	110.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,36JIM@31979|Clostridiaceae	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
XH1_k127_4879983_5	879212.DespoDRAFT_00693	2.27e-45	170.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2WMK3@28221|Deltaproteobacteria,2MJT8@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
XH1_k127_4879983_4	264462.Bd1987	4.844e-67	235.0	COG0834@1|root,COG0834@2|Bacteria,1N8QX@1224|Proteobacteria,431JG@68525|delta/epsilon subdivisions,2MUCQ@213481|Bdellovibrionales,2WWE7@28221|Deltaproteobacteria	213481|Bdellovibrionales	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
XH1_k127_4879983_7	265072.Mfla_0431	3.671e-07	62.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VMS2@28216|Betaproteobacteria,2KN17@206350|Nitrosomonadales	206350|Nitrosomonadales	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
XH1_k127_4879983_1	1121413.JMKT01000008_gene1269	5.443e-150	507.0	COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WKCD@28221|Deltaproteobacteria,2M8VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,SBP_bac_3,dCache_1
XH1_k127_491176_0	760011.Spico_1788	1.279e-141	462.0	COG0205@1|root,COG0205@2|Bacteria,2J6KH@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
XH1_k127_4923600_0	330214.NIDE3287	2.353e-96	334.0	COG0342@1|root,COG0342@2|Bacteria,3J09Z@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
XH1_k127_4923600_1	523791.Kkor_1071	1.68e-54	202.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1XIA9@135619|Oceanospirillales	135619|Oceanospirillales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
XH1_k127_493534_0	1379698.RBG1_1C00001G1642	2.111e-116	383.0	COG0029@1|root,COG0029@2|Bacteria,2NNMD@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.3.5.4,1.4.3.16	ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00115,M00150,M00173	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899	FAD_binding_2,Succ_DH_flav_C
XH1_k127_493534_1	1235457.C404_10360	1.528e-49	186.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,1K1E9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	TIGRFAM hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
XH1_k127_4957979_2	909663.KI867150_gene890	4.71e-09	64.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RP3@68525|delta/epsilon subdivisions,2WNPA@28221|Deltaproteobacteria,2MRZD@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
XH1_k127_4957979_1	1342299.Z947_2868	2.207e-36	145.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,3ZW1X@60136|Sulfitobacter	28211|Alphaproteobacteria	U	MarC family integral membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
XH1_k127_4957979_0	665571.STHERM_c01490	1.656e-103	342.0	COG0111@1|root,COG0111@2|Bacteria,2J6NN@203691|Spirochaetes	203691|Spirochaetes	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
XH1_k127_4964403_0	1313292.BCO_0101700	2.321e-37	153.0	COG0457@1|root,COG0457@2|Bacteria,2J7GS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
XH1_k127_4964403_1	1291050.JAGE01000001_gene1693	6.804e-07	61.0	COG4717@1|root,COG4717@2|Bacteria,1TQP3@1239|Firmicutes,24E0A@186801|Clostridia,3WRCQ@541000|Ruminococcaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
XH1_k127_4973416_0	1274524.BSONL12_09342	2.262e-142	463.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HANQ@91061|Bacilli,1ZBUT@1386|Bacillus	91061|Bacilli	H	Glutamate-1-semialdehyde aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS08395	Aminotran_3
XH1_k127_4973416_2	653733.Selin_0698	1.334e-22	101.0	COG2033@1|root,COG2033@2|Bacteria	2|Bacteria	C	superoxide reductase activity	sorA	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
XH1_k127_4973416_1	716544.wcw_0972	1.757e-65	229.0	COG0260@1|root,COG0260@2|Bacteria,2JFEQ@204428|Chlamydiae	204428|Chlamydiae	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
XH1_k127_4976884_2	706587.Desti_1480	1.406e-55	203.0	COG1024@1|root,COG1024@2|Bacteria,1R8QP@1224|Proteobacteria,42S3Y@68525|delta/epsilon subdivisions,2WNXJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamR	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
XH1_k127_4976884_3	1121405.dsmv_3734	1.959e-54	194.0	COG1545@1|root,COG1545@2|Bacteria,1N4S9@1224|Proteobacteria,42U3D@68525|delta/epsilon subdivisions,2WQNA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
XH1_k127_4976884_0	1121405.dsmv_3735	9.648e-196	616.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,43AZR@68525|delta/epsilon subdivisions,2X6DY@28221|Deltaproteobacteria,2MPHW@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
XH1_k127_4976884_1	909663.KI867150_gene856	4.185e-133	426.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,43AEF@68525|delta/epsilon subdivisions,2X5U8@28221|Deltaproteobacteria,2MRFI@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
XH1_k127_4988936_1	439235.Dalk_0815	6.366e-73	253.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MNC9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
XH1_k127_4988936_0	580331.Thit_2022	3.488e-157	514.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
XH1_k127_4988936_2	1410653.JHVC01000001_gene1445	1.641e-07	56.0	COG0500@1|root,COG2226@2|Bacteria,1UM01@1239|Firmicutes,24H5C@186801|Clostridia	186801|Clostridia	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
XH1_k127_4993463_0	593750.Metfor_0385	5.095e-85	308.0	COG0642@1|root,arCOG02350@1|root,arCOG02327@2157|Archaea,arCOG02350@2157|Archaea,arCOG06192@2157|Archaea,arCOG06193@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF,GAF_2,HATPase_c,HTH_10,HisKA,HisKA_2,HisKA_7TM,PAS,PAS_4,PAS_8,PAS_9,Response_reg
XH1_k127_4993463_1	1049564.TevJSym_ay00160	4.172e-36	158.0	COG2202@1|root,COG2203@1|root,COG3437@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,DUF3365,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
XH1_k127_4994102_1	153721.MYP_3812	6.864e-87	299.0	COG2220@1|root,COG2220@2|Bacteria,4NI69@976|Bacteroidetes,47K8S@768503|Cytophagia	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
XH1_k127_4994102_2	1234593.ANBY01000107_gene605	1.243e-47	181.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,4GXF9@90964|Staphylococcaceae	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
XH1_k127_4994102_0	1340493.JNIF01000003_gene1856	1.618e-151	492.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
XH1_k127_4994102_3	926561.KB900620_gene2911	8.512e-45	173.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
XH1_k127_5009561_2	1410609.JHVB01000001_gene1840	1.107e-15	90.0	COG2604@1|root,COG2604@2|Bacteria,2J5FD@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
XH1_k127_5009561_1	1111479.AXAR01000005_gene628	9.382e-43	163.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,279RN@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08510	CoaE
XH1_k127_5009561_3	161156.JQKW01000007_gene766	8.332e-07	60.0	COG3087@1|root,COG3087@2|Bacteria,2GHQP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
XH1_k127_5009561_0	246194.CHY_2704	4.277e-203	650.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,42FIB@68295|Thermoanaerobacterales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
XH1_k127_5025532_0	335543.Sfum_2789	9.489e-106	357.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MQ7N@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
XH1_k127_5025532_2	1111134.HMPREF1253_1856	1.348e-14	77.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,22HRF@1570339|Peptoniphilaceae	186801|Clostridia	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
XH1_k127_5025532_1	1150600.ADIARSV_2036	2.288e-45	168.0	COG0353@1|root,COG0353@2|Bacteria,4NEWI@976|Bacteroidetes,1INZ4@117747|Sphingobacteriia	976|Bacteroidetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
XH1_k127_5026_3	523845.AQXV01000033_gene458	0.0008446	50.0	COG0500@1|root,arCOG01789@2157|Archaea,2XWZ7@28890|Euryarchaeota,23QTY@183939|Methanococci	183939|Methanococci	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
XH1_k127_5026_2	907348.TresaDRAFT_0070	3.622e-20	99.0	COG0457@1|root,COG0457@2|Bacteria,2J6BA@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
XH1_k127_5026_1	1353529.M899_1559	1.216e-41	162.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
XH1_k127_5026_0	572546.Arcpr_0467	5.634e-50	186.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,245Z4@183980|Archaeoglobi	183980|Archaeoglobi	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
XH1_k127_5043943_2	1499967.BAYZ01000094_gene4049	1.633e-08	57.0	COG1893@1|root,COG1893@2|Bacteria,2NPMG@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
XH1_k127_5043943_0	1499967.BAYZ01000094_gene4049	2.036e-109	362.0	COG1893@1|root,COG1893@2|Bacteria,2NPMG@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
XH1_k127_5043943_1	351160.RCIX2178	6.945e-72	250.0	COG0500@1|root,arCOG01787@2157|Archaea	2157|Archaea	Q	PFAM Methyltransferase type	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
XH1_k127_5046570_0	316067.Geob_1854	3.104e-90	306.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,42R4J@68525|delta/epsilon subdivisions,2WMXH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM import inner membrane translocase, subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	DUF1517,Tim44
XH1_k127_5046570_1	1121403.AUCV01000029_gene2659	1.482e-61	220.0	COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria,43BHB@68525|delta/epsilon subdivisions,2X6VQ@28221|Deltaproteobacteria,2MMMX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF915)	-	-	-	-	-	-	-	-	-	-	-	-	DUF915
XH1_k127_5050582_2	436114.SYO3AOP1_1534	7.896e-05	53.0	COG2834@1|root,COG2834@2|Bacteria,2G5FK@200783|Aquificae	200783|Aquificae	M	outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
XH1_k127_5050582_1	573413.Spirs_1567	2.125e-15	83.0	COG3334@1|root,COG3334@2|Bacteria,2J66F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM MgtE intracellular	flbB	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	-
XH1_k127_5050582_0	204669.Acid345_1154	1.225e-30	128.0	COG0741@1|root,COG0741@2|Bacteria,3Y84I@57723|Acidobacteria,2JNI1@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
XH1_k127_5051495_1	945713.IALB_0896	2.23e-65	228.0	COG0606@1|root,COG0606@2|Bacteria	2|Bacteria	O	chelatase, subunit chli	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
XH1_k127_5051495_0	153721.MYP_2527	1.098e-95	339.0	COG0457@1|root,COG0457@2|Bacteria,4NJEF@976|Bacteroidetes,47Q7U@768503|Cytophagia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_16,TPR_2,TPR_8
XH1_k127_506534_1	1341181.FLJC2902T_23340	2.975e-06	60.0	COG1305@1|root,COG1305@2|Bacteria,4NI6P@976|Bacteroidetes,1HYIY@117743|Flavobacteriia,2NTEA@237|Flavobacterium	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,Transglut_core
XH1_k127_506534_0	1157490.EL26_01195	8.828e-09	63.0	COG0382@1|root,COG0382@2|Bacteria,1TQU5@1239|Firmicutes,4HAGP@91061|Bacilli,277WT@186823|Alicyclobacillaceae	91061|Bacilli	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
XH1_k127_5085093_2	1232410.KI421412_gene348	7.161e-19	87.0	COG1141@1|root,COG1141@2|Bacteria,1Q2EF@1224|Proteobacteria,42VI5@68525|delta/epsilon subdivisions,2WS6Z@28221|Deltaproteobacteria,43SRS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Divergent 4Fe-4S mono-cluster	frx-4	-	-	ko:K05337	-	-	-	-	ko00000	-	-	iAF987.Gmet_0148	Fer4_13
XH1_k127_5085093_3	869209.Tresu_1628	8.862e-08	59.0	COG1314@1|root,COG1314@2|Bacteria,2J7UR@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
XH1_k127_5085093_1	326427.Cagg_0927	3.964e-77	265.0	COG0149@1|root,COG0149@2|Bacteria,2G69W@200795|Chloroflexi,3750D@32061|Chloroflexia	32061|Chloroflexia	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
XH1_k127_5085093_0	1191523.MROS_1920	7.137e-183	576.0	COG0057@1|root,COG0057@2|Bacteria	2|Bacteria	G	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184	Gp_dh_C,Gp_dh_N
XH1_k127_5088144_0	1167006.UWK_00134	2.935e-173	557.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
XH1_k127_5088144_1	1448139.AI20_14120	1.076e-71	247.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1Y5C5@135624|Aeromonadales	135624|Aeromonadales	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
XH1_k127_5100447_0	509191.AEDB02000017_gene98	2.431e-114	376.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,3WHY9@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	-	-	-	-	-	-	-	-	-	ZnuA
XH1_k127_5100447_2	509191.AEDB02000017_gene99	2.769e-88	297.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,248F1@186801|Clostridia,3WHEK@541000|Ruminococcaceae	186801|Clostridia	P	ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
XH1_k127_5100447_1	509191.AEDB02000017_gene100	4.109e-96	321.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,3WGD3@541000|Ruminococcaceae	186801|Clostridia	P	ABC 3 transport family protein	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
XH1_k127_5100447_3	866776.HMPREF9321_1839	3.001e-68	236.0	COG2877@1|root,COG2877@2|Bacteria,1TR2G@1239|Firmicutes,4H20D@909932|Negativicutes	909932|Negativicutes	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
XH1_k127_5122419_1	909663.KI867149_gene3380	1.995e-57	201.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2MQR9@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA-ligase	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA,Succ_CoA_lig
XH1_k127_5122419_0	56780.SYN_03227	1.223e-219	684.0	COG0045@1|root,COG0045@2|Bacteria,1R6QD@1224|Proteobacteria,42P2U@68525|delta/epsilon subdivisions,2WJAY@28221|Deltaproteobacteria,2MRBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ATP-grasp domain	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
XH1_k127_5136708_1	1047013.AQSP01000135_gene1588	1.685e-07	61.0	COG2980@1|root,COG2980@2|Bacteria	2|Bacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788	LptE
XH1_k127_5136708_0	1487921.DP68_08460	7.913e-24	110.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,36E5E@31979|Clostridiaceae	186801|Clostridia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
XH1_k127_5148910_0	56780.SYN_02538	6.076e-95	315.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MQS9@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Adenylate kinase, active site lid	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
XH1_k127_5148910_1	472759.Nhal_2482	5.468e-62	219.0	COG3823@1|root,COG3823@2|Bacteria,1R9YU@1224|Proteobacteria,1RZ5N@1236|Gammaproteobacteria,1WXPE@135613|Chromatiales	135613|Chromatiales	O	PFAM Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
XH1_k127_5154631_0	56780.SYN_00104	6.113e-82	283.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MQKP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
XH1_k127_5154631_1	385682.AFSL01000074_gene1228	0.0006472	48.0	COG0457@1|root,COG0457@2|Bacteria,4NGGZ@976|Bacteroidetes,2FMHN@200643|Bacteroidia,3XJ4U@558415|Marinilabiliaceae	976|Bacteroidetes	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8
XH1_k127_5164281_1	1120951.AUBG01000013_gene2670	2.106e-09	63.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,4NFWN@976|Bacteroidetes,1HWTQ@117743|Flavobacteriia	976|Bacteroidetes	O	redox protein regulator of disulfide bond formation	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
XH1_k127_5164281_0	56780.SYN_02638	2.632e-190	613.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2MQYC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_10,Fer4_8,Nitrate_red_gam
XH1_k127_5212059_0	56780.SYN_02201	0.0	1073.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
XH1_k127_5321509_0	1499967.BAYZ01000095_gene4149	7.125e-28	117.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
XH1_k127_5352458_0	439235.Dalk_5143	1.157e-12	79.0	COG1729@1|root,COG1729@2|Bacteria,1RGD4@1224|Proteobacteria,42S9U@68525|delta/epsilon subdivisions,2WP0U@28221|Deltaproteobacteria,2MK2Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,YfiO
XH1_k127_5352458_1	1191523.MROS_0418	6.23e-07	55.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	ybgF	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6
XH1_k127_5373699_0	760568.Desku_1394	1.053e-179	580.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0182	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
XH1_k127_5380343_2	768670.Calni_1984	8.695e-25	107.0	COG0534@1|root,COG0534@2|Bacteria,2GFAB@200930|Deferribacteres	200930|Deferribacteres	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
XH1_k127_5380343_1	1499967.BAYZ01000036_gene2422	3.539e-54	194.0	COG2033@1|root,COG2033@2|Bacteria	2|Bacteria	C	superoxide reductase activity	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
XH1_k127_5380343_0	335543.Sfum_2639	1.548e-152	506.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MQVW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
XH1_k127_5383776_1	1121472.AQWN01000004_gene906	5.569e-22	99.0	COG0340@1|root,COG0340@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,260CI@186807|Peptococcaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
XH1_k127_5383776_0	641491.DND132_1073	2.917e-147	484.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M8JP@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,sCache_2
XH1_k127_5393762_0	697282.Mettu_1717	1.331e-142	469.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XFYS@135618|Methylococcales	135618|Methylococcales	NT	Signal transduction histidine kinase, phosphotransfer (Hpt) region	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
XH1_k127_5411888_2	517418.Ctha_2626	6.443e-35	141.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	ccmA	-	3.6.3.41	ko:K01990,ko:K02193	ko02010,map02010	M00254,M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.107	-	-	ABC_tran
XH1_k127_5411888_1	1379698.RBG1_1C00001G0423	8.88e-40	156.0	COG2386@1|root,COG2386@2|Bacteria,2NPHG@2323|unclassified Bacteria	2|Bacteria	O	CcmB protein	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193,ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	iECO111_1330.ECO111_2936,iYL1228.KPN_02080	CcmB
XH1_k127_5411888_0	880073.Calab_2348	1.033e-53	196.0	COG0755@1|root,COG0755@2|Bacteria,2NPGT@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C assembly protein	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
XH1_k127_5441701_1	1379281.AVAG01000077_gene1597	5.215e-41	153.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,2MB3K@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
XH1_k127_5441701_0	349161.Dred_0202	5.948e-58	208.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,260QW@186807|Peptococcaceae	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
XH1_k127_5441701_4	555079.Toce_2105	4.321e-10	62.0	COG0690@1|root,COG0690@2|Bacteria,1UEKM@1239|Firmicutes,25JJ4@186801|Clostridia,42HEH@68295|Thermoanaerobacterales	186801|Clostridia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
XH1_k127_5441701_3	1379858.N508_00383	3.292e-16	78.0	COG0267@1|root,COG0267@2|Bacteria,2GFZW@200930|Deferribacteres	200930|Deferribacteres	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
XH1_k127_5441701_2	868864.Dester_0328	9.232e-32	136.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,2G44W@200783|Aquificae	200783|Aquificae	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
XH1_k127_5449292_0	316067.Geob_0069	4.396e-48	192.0	28JHJ@1|root,2Z9B3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_5453658_0	56780.SYN_00416	2.259e-165	524.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MR55@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
XH1_k127_5453658_2	56780.SYN_00305	9.249e-40	158.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MQFF@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
XH1_k127_5453658_1	945713.IALB_1271	1.869e-140	456.0	COG0126@1|root,COG0126@2|Bacteria	2|Bacteria	F	phosphoglycerate kinase activity	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
XH1_k127_5453658_3	1026882.MAMP_03016	2.266e-24	115.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,460AB@72273|Thiotrichales	72273|Thiotrichales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
XH1_k127_546032_0	595460.RRSWK_04260	6.186e-16	92.0	COG3119@1|root,COG3119@2|Bacteria,2IXR4@203682|Planctomycetes	203682|Planctomycetes	P	COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
XH1_k127_548958_1	1267005.KB911261_gene2243	6.424e-191	602.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,3N6BR@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
XH1_k127_548958_0	1158318.ATXC01000001_gene1277	4.773e-270	847.0	COG0480@1|root,COG0480@2|Bacteria,2G3NW@200783|Aquificae	200783|Aquificae	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
XH1_k127_5500647_1	754436.JCM19237_3504	5.181e-17	88.0	COG3417@1|root,COG3417@2|Bacteria,1RA6V@1224|Proteobacteria,1S30E@1236|Gammaproteobacteria,1XUJ6@135623|Vibrionales	135623|Vibrionales	M	Collagen-binding surface adhesin SpaP (Antigen I II family)	lpoB	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
XH1_k127_5500647_0	215803.DB30_2303	1.382e-30	137.0	COG3014@1|root,COG3014@2|Bacteria,1PD4S@1224|Proteobacteria,42V8Q@68525|delta/epsilon subdivisions,2WRSG@28221|Deltaproteobacteria,2YW0X@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
XH1_k127_5501899_1	742723.HMPREF9477_01062	6.806e-53	194.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,27J92@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
XH1_k127_5501899_0	509191.AEDB02000022_gene2993	5.581e-205	650.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,3WGIN@541000|Ruminococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
XH1_k127_5519_1	439235.Dalk_3322	6.553e-47	177.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WJS7@28221|Deltaproteobacteria,2MIWA@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
XH1_k127_5519_0	338963.Pcar_2002	3.017e-47	175.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2WPHH@28221|Deltaproteobacteria,43SH2@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Peptidyl-tRNA hydrolase	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
XH1_k127_5519_2	439235.Dalk_4482	4.234e-30	124.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions,2WP7J@28221|Deltaproteobacteria,2MK8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	cheY34H-1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
XH1_k127_5524300_5	1120972.AUMH01000017_gene726	2.938e-24	104.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,4HKDN@91061|Bacilli,27A6H@186823|Alicyclobacillaceae	91061|Bacilli	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
XH1_k127_5524300_6	453591.Igni_0591	0.0005538	45.0	COG0255@1|root,arCOG00785@2157|Archaea,2XRDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uL29 family	rpl29	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
XH1_k127_5524300_2	335543.Sfum_1562	1.253e-55	197.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria,2MQGG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
XH1_k127_5524300_1	857293.CAAU_1221	7.161e-75	258.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,36ETZ@31979|Clostridiaceae	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
XH1_k127_5524300_4	1121403.AUCV01000025_gene2251	1.056e-25	109.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MKFE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
XH1_k127_5524300_3	398512.JQKC01000042_gene4190	8.005e-38	143.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,3WJ9F@541000|Ruminococcaceae	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
XH1_k127_5524300_0	1499967.BAYZ01000114_gene2887	8.763e-96	317.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
XH1_k127_5524729_1	1305836.AXVE01000012_gene34	8.695e-65	243.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1UYNI@1239|Firmicutes,4IUF0@91061|Bacilli	91061|Bacilli	T	diguanylate cyclase	-	-	2.7.7.65	ko:K18967	-	-	-	-	ko00000,ko01000,ko02000	9.B.34.1.1	-	-	5TM-5TMR_LYT,GGDEF
XH1_k127_5524729_0	497964.CfE428DRAFT_0737	1.168e-113	383.0	COG0265@1|root,COG0265@2|Bacteria,46UAN@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
XH1_k127_5540709_1	37659.JNLN01000001_gene2461	1.587e-17	86.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,36K1I@31979|Clostridiaceae	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
XH1_k127_5540709_0	1045858.Bint_0537	1.833e-207	662.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
XH1_k127_5572433_1	1304885.AUEY01000037_gene2208	1.78e-110	364.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2MI94@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
XH1_k127_5572433_0	1304885.AUEY01000037_gene2207	6.894e-124	406.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2MIY1@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
XH1_k127_557244_0	1167006.UWK_00151	6.083e-208	677.0	COG0500@1|root,COG4258@1|root,COG0500@2|Bacteria,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,42P70@68525|delta/epsilon subdivisions,2WJGD@28221|Deltaproteobacteria,2MJYG@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
XH1_k127_557244_1	1121403.AUCV01000014_gene4645	5.38e-21	94.0	COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,42NYG@68525|delta/epsilon subdivisions,2WIXP@28221|Deltaproteobacteria,2MITR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF2062,Glycos_transf_2
XH1_k127_5575950_1	933262.AXAM01000002_gene535	2.209e-69	239.0	COG0502@1|root,COG0502@2|Bacteria,1MXK0@1224|Proteobacteria,42M3U@68525|delta/epsilon subdivisions,2WJQ6@28221|Deltaproteobacteria,2MHKZ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Biotin and Thiamin Synthesis associated	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
XH1_k127_5575950_0	118161.KB235922_gene1232	7.903e-144	488.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3VIJ3@52604|Pleurocapsales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9
XH1_k127_5575950_3	1408424.JHYI01000001_gene2109	4.521e-24	109.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,4HGXT@91061|Bacilli,1ZFNI@1386|Bacillus	91061|Bacilli	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
XH1_k127_5575950_4	886293.Sinac_1910	5.699e-16	91.0	COG1397@1|root,COG1397@2|Bacteria,2IZFE@203682|Planctomycetes	203682|Planctomycetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
XH1_k127_5575950_2	573370.DMR_25400	3.594e-48	181.0	COG0750@1|root,COG0750@2|Bacteria,1PZ8K@1224|Proteobacteria,435TD@68525|delta/epsilon subdivisions,2X9CN@28221|Deltaproteobacteria,2MB7X@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M50
XH1_k127_560567_0	639282.DEFDS_0507	1.347e-222	705.0	COG0525@1|root,COG0525@2|Bacteria,2GF6T@200930|Deferribacteres	200930|Deferribacteres	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
XH1_k127_560567_2	551275.KB899549_gene753	7.27e-23	103.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,43YBU@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	MA20_39715	-	-	-	-	-	-	-	-	-	-	-	DUF1178
XH1_k127_560567_1	1237149.C900_00749	3.944e-24	113.0	COG2885@1|root,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,47KG7@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
XH1_k127_5612474_0	1410609.JHVB01000001_gene1798	1.863e-55	218.0	COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
XH1_k127_5612474_1	1111131.HMPREF1255_0138	1.679e-34	133.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DN4J@85009|Propionibacteriales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
XH1_k127_5624434_0	5888.CAK91897	4.592e-29	123.0	COG5253@1|root,KOG0229@2759|Eukaryota	2759|Eukaryota	T	1-phosphatidylinositol-4-phosphate 5-kinase activity	-	-	-	ko:K14972	-	-	-	-	ko00000,ko03036	-	-	-	IQ,MORN
XH1_k127_5624434_1	574966.KB898647_gene2250	7.402e-08	66.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1XRAY@135619|Oceanospirillales	135619|Oceanospirillales	G	Domain of unknown function (DUF3459)	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,DUF3459
XH1_k127_562837_1	945713.IALB_1926	0.0001016	55.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
XH1_k127_562837_0	1191523.MROS_0087	4.403e-05	56.0	COG1649@1|root,COG3250@1|root,COG3401@1|root,COG4733@1|root,COG1649@2|Bacteria,COG3250@2|Bacteria,COG3401@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	yesX	-	3.2.1.11,3.2.1.18,3.2.1.35,3.2.1.51,4.2.2.23,4.2.2.24	ko:K01186,ko:K01197,ko:K01206,ko:K05988,ko:K11931,ko:K18197,ko:K18198	ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142	M00076,M00077	R04018,R07824,R07825,R10905,R11309	RC00028,RC00077	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042,ko04147	-	GH29,GH33,GH66,PL11	-	GHL10,fn3
XH1_k127_5638234_0	1123288.SOV_1c00080	7.54e-205	649.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,4H4SY@909932|Negativicutes	909932|Negativicutes	E	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR,MTHFR_C
XH1_k127_5638234_2	436229.JOEH01000009_gene4564	3.989e-06	49.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria,2NJKA@228398|Streptacidiphilus	201174|Actinobacteria	K	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
XH1_k127_5638234_1	1124780.ANNU01000015_gene1983	1.314e-10	67.0	COG2172@1|root,COG2172@2|Bacteria,4NRAA@976|Bacteroidetes,47QUX@768503|Cytophagia	976|Bacteroidetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	rsbW	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
XH1_k127_5658396_3	1378168.N510_01487	7.773e-42	162.0	COG1861@1|root,COG1861@2|Bacteria,1U4YD@1239|Firmicutes	1239|Firmicutes	M	cytidylyl-transferase	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
XH1_k127_5658396_2	869209.Tresu_1174	4.047e-46	184.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
XH1_k127_5658396_4	1313421.JHBV01000030_gene2187	2.1e-06	59.0	COG0760@1|root,COG0760@2|Bacteria,4NGIR@976|Bacteroidetes,1IPZ1@117747|Sphingobacteriia	976|Bacteroidetes	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
XH1_k127_5658396_1	404380.Gbem_0275	3.322e-69	243.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,43TAQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
XH1_k127_5658396_0	926561.KB900620_gene3154	1.939e-183	587.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,3WACK@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
XH1_k127_5664058_2	37919.EP51_03935	5.747e-06	59.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4FWK9@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
XH1_k127_5664058_1	1280680.AUJU01000005_gene1537	3.99e-46	172.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1UMUT@1239|Firmicutes,24FBZ@186801|Clostridia,4C0Y3@830|Butyrivibrio	186801|Clostridia	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
XH1_k127_5664058_0	1131269.AQVV01000005_gene390	2.343e-66	244.0	COG1199@1|root,COG1199@2|Bacteria	2|Bacteria	L	ATP-dependent helicase activity	dinG	GO:0003674,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:1901360	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
XH1_k127_5666839_2	555079.Toce_0086	4.516e-19	91.0	COG0247@1|root,COG0493@1|root,COG0247@2|Bacteria,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.17.1.9,1.97.1.9	ko:K00123,ko:K12527,ko:K15022	ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519,R07229	RC02420,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer4_17,Fer4_20,NAD_binding_8,Pyr_redox_2
XH1_k127_5666839_1	304371.MCP_1188	3.981e-39	155.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,2N9JS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
XH1_k127_5666839_0	196162.Noca_1623	3.951e-172	546.0	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	cbaA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
XH1_k127_5703362_3	1313301.AUGC01000008_gene488	0.0001261	49.0	2E6VI@1|root,331F4@2|Bacteria,4NWUI@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_5703362_0	1131462.DCF50_p613	7.221e-64	222.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,261H1@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
XH1_k127_5703362_2	565034.BHWA1_00950	1.059e-32	131.0	COG0781@1|root,COG0781@2|Bacteria,2J91Y@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
XH1_k127_5703362_1	211165.AJLN01000116_gene3283	1.647e-51	205.0	COG0457@1|root,COG0457@2|Bacteria,1GJSD@1117|Cyanobacteria,1JJK6@1189|Stigonemataceae	1117|Cyanobacteria	O	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8,Trypsin_2
XH1_k127_571137_1	926692.AZYG01000040_gene1498	1.357e-20	100.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,3WAUU@53433|Halanaerobiales	186801|Clostridia	O	PFAM Glycoprotease family	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
XH1_k127_571137_0	877424.ATWC01000002_gene2689	1.345e-33	134.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,27MWC@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
XH1_k127_5713686_1	1524467.IV04_19985	2.337e-57	205.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,3ZZRU@613|Serratia	1236|Gammaproteobacteria	C	with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113,ko:K11473	ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130	-	R00475,R00848	RC00029,RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
XH1_k127_5713686_0	96561.Dole_1020	3.524e-102	346.0	COG3075@1|root,COG3075@2|Bacteria,1MU3K@1224|Proteobacteria,42Q09@68525|delta/epsilon subdivisions,2WKE0@28221|Deltaproteobacteria,2MJI8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Anaerobic glycerol-3-phosphate dehydrogenase, subunit	glpB	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
XH1_k127_5716064_0	909663.KI867150_gene1278	1.42e-243	756.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJN6@28221|Deltaproteobacteria,2MQ5G@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
XH1_k127_5716064_1	722419.PH505_ab01600	2.776e-56	211.0	COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,1NSQ1@1224|Proteobacteria,1RMUV@1236|Gammaproteobacteria,2Q1FS@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_4
XH1_k127_5717315_1	580332.Slit_1588	3.749e-29	121.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,44W69@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Signal transducing histidine kinase homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
XH1_k127_5717315_0	880073.Calab_0899	9.416e-149	485.0	COG0514@1|root,COG0514@2|Bacteria,2NNZU@2323|unclassified Bacteria	2|Bacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,Pribosyltran,RQC,RecQ_Zn_bind
XH1_k127_5720787_1	180332.JTGN01000025_gene1550	3.269e-07	53.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia	186801|Clostridia	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
XH1_k127_5720787_0	545695.TREAZ_0913	2.314e-09	67.0	2EY48@1|root,33RD4@2|Bacteria,2J65N@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
XH1_k127_5724579_0	748449.Halha_0964	9.271e-122	403.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WA7U@53433|Halanaerobiales	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
XH1_k127_5724579_1	443254.Marpi_1654	6.735e-11	67.0	COG3279@1|root,COG3279@2|Bacteria,2GD2T@200918|Thermotogae	200918|Thermotogae	K	PFAM response regulator receiver	-	-	-	ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
XH1_k127_5727683_0	1346330.M472_12090	8.407e-14	83.0	COG3637@1|root,COG3637@2|Bacteria,4NH6A@976|Bacteroidetes	976|Bacteroidetes	M	Domain of unknown function (DUF3943)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3943
XH1_k127_5745480_0	378806.STAUR_7128	2.929e-37	162.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
XH1_k127_5759081_0	56780.SYN_01965	2.566e-100	336.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,42YQ4@68525|delta/epsilon subdivisions,2WTPM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EH	PFAM Thiamine pyrophosphate	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
XH1_k127_5759081_2	1118059.CAHC01000012_gene336	4.25e-43	167.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,3WCE8@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
XH1_k127_5759081_1	1321814.HMPREF9089_01317	4.753e-53	192.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25USF@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
XH1_k127_5759081_3	858215.Thexy_1245	1.134e-27	122.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,42ENI@68295|Thermoanaerobacterales	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
XH1_k127_5767552_0	293826.Amet_3058	2.63e-31	142.0	COG0658@1|root,COG0658@2|Bacteria,1VHTG@1239|Firmicutes,25F1C@186801|Clostridia,36UUZ@31979|Clostridiaceae	186801|Clostridia	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
XH1_k127_5767725_2	1521187.JPIM01000013_gene2750	4.743e-58	221.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,3772K@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
XH1_k127_5767725_1	869213.JCM21142_334	2.713e-187	596.0	COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,47M2V@768503|Cytophagia	976|Bacteroidetes	E	TIGRFAM glutamate synthases, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
XH1_k127_5767725_0	1316936.K678_03312	2.329e-258	811.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales	204441|Rhodospirillales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
XH1_k127_577496_0	879212.DespoDRAFT_00867	9.942e-256	827.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	68525|delta/epsilon subdivisions	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
XH1_k127_5786725_0	748449.Halha_2229	4.207e-118	391.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,3WACX@53433|Halanaerobiales	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
XH1_k127_5790381_0	545694.TREPR_0311	7.302e-109	363.0	COG0484@1|root,COG0484@2|Bacteria,2J614@203691|Spirochaetes	203691|Spirochaetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
XH1_k127_5799283_0	909663.KI867150_gene867	1.139e-86	297.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MRGG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM formate dehydrogenase, alpha subunit	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
XH1_k127_5799283_2	768704.Desmer_1537	4.827e-42	164.0	COG0437@1|root,COG0437@2|Bacteria,1TT2G@1239|Firmicutes,24DAZ@186801|Clostridia,261IB@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM formate dehydrogenase, beta subunit, Fe-S containing	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Fer4_7,Form-deh_trans
XH1_k127_5799283_1	203119.Cthe_0278	6.208e-86	289.0	COG0564@1|root,COG0564@2|Bacteria,1TX59@1239|Firmicutes,24HTV@186801|Clostridia,3WHF8@541000|Ruminococcaceae	186801|Clostridia	J	Pseudouridine synthase	rluC	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
XH1_k127_5799283_3	203119.Cthe_0277	2.828e-31	124.0	COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,2480X@186801|Clostridia,3WGYH@541000|Ruminococcaceae	186801|Clostridia	J	S-adenosylmethionine-dependent methyltransferase	rlmL_1	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
XH1_k127_5856259_1	526224.Bmur_0389	0.0007303	48.0	COG1315@1|root,COG1315@2|Bacteria,2J5P2@203691|Spirochaetes	203691|Spirochaetes	L	PALM domain HD hydrolase domain and	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
XH1_k127_5856259_0	926561.KB900617_gene1203	2.687e-176	578.0	COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,3WB3C@53433|Halanaerobiales	186801|Clostridia	T	Signal transducing histidine kinase, homodimeric domain	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
XH1_k127_5863833_1	706587.Desti_0160	4.131e-126	406.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2MQV0@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
XH1_k127_5863833_0	909663.KI867150_gene1403	8.292e-175	552.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2X5GV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
XH1_k127_5866677_1	247490.KSU1_A0086	9.174e-52	191.0	COG0642@1|root,COG2205@2|Bacteria,2J4XW@203682|Planctomycetes	203682|Planctomycetes	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
XH1_k127_5866677_2	237368.SCABRO_00636	1.97e-30	123.0	COG0745@1|root,COG0745@2|Bacteria,2J3JT@203682|Planctomycetes	203682|Planctomycetes	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
XH1_k127_5866677_0	880073.Calab_2422	3.395e-136	458.0	COG1449@1|root,COG1449@2|Bacteria,2NQNB@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
XH1_k127_5866677_3	1480694.DC28_10940	6.157e-08	55.0	COG0671@1|root,COG0671@2|Bacteria,2J7YV@203691|Spirochaetes	203691|Spirochaetes	I	Membrane-associated phospholipid phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
XH1_k127_5879395_0	500635.MITSMUL_03674	8.641e-119	395.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4H20Q@909932|Negativicutes	909932|Negativicutes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
XH1_k127_5879395_1	1033744.CAEL01000019_gene132	9.305e-57	207.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,22G0T@1570339|Peptoniphilaceae	186801|Clostridia	O	Peptidase, U32 family	yegQ	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
XH1_k127_5882024_1	945713.IALB_3039	7.041e-06	56.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_5882024_0	1499967.BAYZ01000150_gene1704	3.785e-44	169.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
XH1_k127_5896124_0	1121434.AULY01000009_gene2098	2.747e-89	302.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2M7XK@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
XH1_k127_5896124_1	1433287.X808_10470	2.1e-10	64.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1Y77F@135625|Pasteurellales	135625|Pasteurellales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
XH1_k127_5918148_1	439235.Dalk_2367	3.951e-51	183.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MK9G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Desulfoferrodoxin ferrous iron-binding	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
XH1_k127_5918148_0	552811.Dehly_1194	1.435e-81	274.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
XH1_k127_5918148_3	909663.KI867150_gene1753	1.651e-11	66.0	2EK17@1|root,33DRQ@2|Bacteria,1NNYN@1224|Proteobacteria,42WT5@68525|delta/epsilon subdivisions,2WSVU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_5918148_2	696281.Desru_0380	2.064e-40	153.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,24NZG@186801|Clostridia	186801|Clostridia	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
XH1_k127_5974020_0	1125863.JAFN01000001_gene2473	6.084e-168	537.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
XH1_k127_5974020_1	641112.ACOK01000004_gene3762	8.968e-05	50.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,3WKIF@541000|Ruminococcaceae	186801|Clostridia	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,Dockerin_1
XH1_k127_5984418_0	1121405.dsmv_0180	6e-115	385.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJ30@28221|Deltaproteobacteria,2MIR5@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
XH1_k127_5984418_1	118161.KB235922_gene1747	0.0005621	42.0	COG0500@1|root,COG2226@2|Bacteria,1G4C1@1117|Cyanobacteria,3VN9M@52604|Pleurocapsales	1117|Cyanobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
XH1_k127_6063108_0	909663.KI867150_gene2949	9.026e-142	454.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
XH1_k127_6063108_1	909663.KI867150_gene2253	5.972e-80	272.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,2MRSU@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
XH1_k127_6063108_2	909663.KI867150_gene2252	4.973e-34	132.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MR22@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
XH1_k127_607004_0	4787.PITG_03757T0	7.779e-86	296.0	COG0464@1|root,KOG0730@2759|Eukaryota,3QE1H@4776|Peronosporales	4776|Peronosporales	O	Holliday junction DNA helicase ruvB N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	AAA
XH1_k127_6081657_2	933262.AXAM01000030_gene804	4.914e-67	237.0	COG2159@1|root,COG2159@2|Bacteria,1Q0A4@1224|Proteobacteria,42Q9N@68525|delta/epsilon subdivisions,2WJTE@28221|Deltaproteobacteria,2MI7C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
XH1_k127_6081657_3	536232.CLM_1992	1.191e-12	70.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,24UXU@186801|Clostridia,36NYN@31979|Clostridiaceae	186801|Clostridia	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
XH1_k127_6081657_1	1031288.AXAA01000007_gene827	3.224e-98	331.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,36GDV@31979|Clostridiaceae	186801|Clostridia	O	PFAM AIR synthase related protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
XH1_k127_6081657_0	1122217.KB899575_gene1945	1.558e-114	379.0	COG0409@1|root,COG0409@2|Bacteria,1TPM7@1239|Firmicutes,4H25H@909932|Negativicutes	909932|Negativicutes	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
XH1_k127_6093703_0	56780.SYN_02898	2.306e-223	703.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MCF@68525|delta/epsilon subdivisions,2WJRK@28221|Deltaproteobacteria,2MQ9A@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	benzoate-CoA ligase	bamY	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2143	AMP-binding,AMP-binding_C
XH1_k127_6103702_0	329726.AM1_2070	1.11e-55	206.0	COG0616@1|root,COG0616@2|Bacteria,1G6XQ@1117|Cyanobacteria	1117|Cyanobacteria	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
XH1_k127_6103702_1	203119.Cthe_1279	1.249e-17	85.0	COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,3WKM9@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
XH1_k127_610593_2	439235.Dalk_0394	5.329e-44	167.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MJ9P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
XH1_k127_610593_1	1304866.K413DRAFT_1150	1.043e-54	202.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,36DEP@31979|Clostridiaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
XH1_k127_610593_0	1379281.AVAG01000001_gene249	1.998e-182	580.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2M8XA@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM glutamine synthetase catalytic region	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
XH1_k127_610593_3	517417.Cpar_1163	1.381e-22	97.0	2ES6V@1|root,33JRM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_6111634_0	237368.SCABRO_03088	3.358e-19	97.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
XH1_k127_6111634_1	933262.AXAM01000001_gene405	1.657e-09	69.0	COG0535@1|root,COG4706@1|root,COG0535@2|Bacteria,COG4706@2|Bacteria,1R5RB@1224|Proteobacteria,42NU3@68525|delta/epsilon subdivisions,2WJ27@28221|Deltaproteobacteria,2MJDN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
XH1_k127_6111634_2	744872.Spica_1493	4.505e-05	55.0	COG4254@1|root,COG4254@2|Bacteria,2J9KS@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
XH1_k127_6122977_0	318161.Sden_3296	1.083e-176	574.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,2QAPV@267890|Shewanellaceae	1236|Gammaproteobacteria	T	CheA signal transduction histidine	cheA3	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
XH1_k127_6134508_0	1499967.BAYZ01000050_gene2808	2.505e-171	542.0	COG1087@1|root,COG1087@2|Bacteria,2NNVI@2323|unclassified Bacteria	2|Bacteria	M	NAD(P)H-binding	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
XH1_k127_6134508_1	32057.KB217478_gene482	2.442e-51	185.0	COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria,1HSF7@1161|Nostocales	1117|Cyanobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
XH1_k127_6144917_3	868864.Dester_0474	2.727e-24	105.0	COG0771@1|root,COG0771@2|Bacteria,2G3XE@200783|Aquificae	200783|Aquificae	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
XH1_k127_6144917_0	796606.BMMGA3_05665	1.934e-89	308.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4HAEV@91061|Bacilli,1ZBY5@1386|Bacillus	91061|Bacilli	D	Belongs to the SEDS family	spoVE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
XH1_k127_6144917_1	373903.Hore_09090	1.77e-53	202.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,3WAI5@53433|Halanaerobiales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
XH1_k127_6144917_2	338966.Ppro_3288	8.797e-28	113.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,43U76@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
XH1_k127_6149817_0	880070.Cycma_3394	5.449e-34	147.0	COG0860@1|root,COG0860@2|Bacteria,4NGF0@976|Bacteroidetes,47XQ3@768503|Cytophagia	976|Bacteroidetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
XH1_k127_6175024_0	243164.DET0667	2.076e-96	319.0	COG2069@1|root,COG2069@2|Bacteria,2GAQI@200795|Chloroflexi,34D30@301297|Dehalococcoidia	301297|Dehalococcoidia	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
XH1_k127_6175024_2	909663.KI867150_gene99	6.607e-13	71.0	28X5T@1|root,2ZJ48@2|Bacteria,1PA6H@1224|Proteobacteria,433JG@68525|delta/epsilon subdivisions,2WXHP@28221|Deltaproteobacteria,2MSBK@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_6175024_1	909663.KI867150_gene100	7.028e-85	284.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2MQ6N@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
XH1_k127_6210173_0	1250006.JHZZ01000001_gene1166	0.0006595	53.0	COG0457@1|root,COG0457@2|Bacteria,4NE2V@976|Bacteroidetes,1HWRP@117743|Flavobacteriia,3VV2V@52959|Polaribacter	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_6,TPR_8
XH1_k127_6222649_0	909663.KI867150_gene677	1.37e-185	587.0	COG2309@1|root,COG2309@2|Bacteria,1MW2Y@1224|Proteobacteria,42P6P@68525|delta/epsilon subdivisions,2WJF8@28221|Deltaproteobacteria,2MQZ9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
XH1_k127_6222649_3	279714.FuraDRAFT_0398	3.914e-12	75.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2VSJD@28216|Betaproteobacteria,2KQTI@206351|Neisseriales	206351|Neisseriales	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
XH1_k127_6222649_2	386456.JQKN01000002_gene2710	9.799e-96	325.0	COG1893@1|root,arCOG04139@2157|Archaea,2XW0P@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
XH1_k127_6222649_1	909663.KI867150_gene1540	1.054e-96	321.0	COG0006@1|root,COG0006@2|Bacteria,1MVJK@1224|Proteobacteria,43DQS@68525|delta/epsilon subdivisions,2X6WA@28221|Deltaproteobacteria,2MR15@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
XH1_k127_624894_0	56780.SYN_02188	1.509e-102	337.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ATP_bind_3
XH1_k127_624894_2	1123399.AQVE01000024_gene2833	4.313e-08	64.0	COG0681@1|root,COG0681@2|Bacteria,1RKJ5@1224|Proteobacteria,1SQN5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Signal peptidase, peptidase S26	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
XH1_k127_624894_1	335543.Sfum_1138	2.366e-38	146.0	COG0491@1|root,COG0491@2|Bacteria,1P5NJ@1224|Proteobacteria,42SWC@68525|delta/epsilon subdivisions,2WPQZ@28221|Deltaproteobacteria,2MRNM@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
XH1_k127_6254721_0	269799.Gmet_2270	1.037e-155	512.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acyl-coa dehydrogenase	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
XH1_k127_6265673_6	1443122.Z958_08695	9.743e-10	61.0	28NR9@1|root,2ZBQJ@2|Bacteria,1UZEN@1239|Firmicutes,24G0V@186801|Clostridia,36I0Y@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_6265673_5	1317122.ATO12_24850	7.866e-23	103.0	COG5642@1|root,COG5642@2|Bacteria,4NX1V@976|Bacteroidetes,1I30M@117743|Flavobacteriia,2YHWD@290174|Aquimarina	976|Bacteroidetes	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
XH1_k127_6265673_4	1123057.P872_21610	2.909e-37	145.0	COG5654@1|root,COG5654@2|Bacteria,4NQ91@976|Bacteroidetes,47SA7@768503|Cytophagia	976|Bacteroidetes	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
XH1_k127_6265673_2	742817.HMPREF9449_00384	1.643e-48	181.0	COG2095@1|root,COG2095@2|Bacteria,4NZQ3@976|Bacteroidetes,2G29I@200643|Bacteroidia,22ZYY@171551|Porphyromonadaceae	976|Bacteroidetes	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
XH1_k127_6265673_7	509191.AEDB02000021_gene3086	1.18e-09	69.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_6265673_3	237368.SCABRO_02034	7.524e-42	161.0	COG4642@1|root,COG4642@2|Bacteria	2|Bacteria	S	regulation of ryanodine-sensitive calcium-release channel activity	-	-	-	-	-	-	-	-	-	-	-	-	MORN
XH1_k127_6265673_0	526222.Desal_0137	5.516e-123	401.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2M8BZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM transferase hexapeptide repeat containing protein	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
XH1_k127_6265673_1	1487921.DP68_07115	5.757e-110	370.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,36EFR@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
XH1_k127_6267307_1	1301098.PKB_3081	5.274e-34	133.0	COG0598@1|root,COG0598@2|Bacteria,1RGGI@1224|Proteobacteria,1SJ58@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transporter	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
XH1_k127_6267307_0	714943.Mucpa_6698	1.673e-174	555.0	COG1415@1|root,COG1415@2|Bacteria,4NG24@976|Bacteroidetes,1IR2S@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
XH1_k127_6267307_2	28072.Nos7524_1668	5.69e-18	85.0	COG0642@1|root,COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
XH1_k127_6287347_0	1121440.AUMA01000009_gene671	1.087e-87	300.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,2MA1B@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	O-methyltransferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
XH1_k127_6287347_1	472759.Nhal_3806	3.479e-14	76.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales	135613|Chromatiales	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
XH1_k127_63044_0	945713.IALB_0396	1.548e-118	394.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	crtD	-	1.3.99.26,1.3.99.27,1.3.99.28,1.3.99.29,1.3.99.31,5.4.99.9	ko:K01854,ko:K09845,ko:K10027	ko00052,ko00520,ko00906,ko01100,ko01110,map00052,map00520,map00906,map01100,map01110	-	R00505,R04787,R04798,R04800,R07517,R07520,R07523,R07534,R09009,R09691,R09692	RC00317,RC01214,RC02080,RC02088,RC02396,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
XH1_k127_6328502_0	204669.Acid345_2620	8.558e-89	304.0	COG0773@1|root,COG0773@2|Bacteria,3Y2M2@57723|Acidobacteria,2JIE2@204432|Acidobacteriia	204432|Acidobacteriia	M	Mur ligase middle domain	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
XH1_k127_6328502_1	1123277.KB893172_gene855	6.981e-67	239.0	COG0463@1|root,COG0463@2|Bacteria,4NEZP@976|Bacteroidetes,47MB5@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_4
XH1_k127_6343551_1	706587.Desti_1112	5.215e-100	331.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
XH1_k127_6343551_0	289376.THEYE_A0592	2.021e-103	351.0	COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae	40117|Nitrospirae	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
XH1_k127_6343551_2	390236.BafPKo_0839	1.139e-11	77.0	COG1413@1|root,COG1413@2|Bacteria,2J5WK@203691|Spirochaetes	203691|Spirochaetes	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
XH1_k127_6343551_3	1347086.CCBA010000010_gene1740	0.0002425	44.0	COG3458@1|root,COG3458@2|Bacteria,1V2Z0@1239|Firmicutes,4IRU6@91061|Bacilli,1ZQXC@1386|Bacillus	91061|Bacilli	Q	Acetyl xylan esterase (AXE1)	cah3	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
XH1_k127_634877_0	573063.Metin_1240	5.069e-28	126.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,23Q6S@183939|Methanococci	183939|Methanococci	S	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
XH1_k127_634877_1	573413.Spirs_1319	2.59e-21	108.0	COG2203@1|root,COG2208@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3850@2|Bacteria,2J5K8@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
XH1_k127_6356835_0	485918.Cpin_1363	6.753e-95	330.0	COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,1IXR8@117747|Sphingobacteriia	976|Bacteroidetes	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
XH1_k127_6356835_1	243231.GSU2049	4.988e-83	287.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,43TJH@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
XH1_k127_6360261_0	1289135.A966_02566	1.058e-165	531.0	COG0445@1|root,COG0445@2|Bacteria,2J5A1@203691|Spirochaetes	203691|Spirochaetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
XH1_k127_6360261_1	1286171.EAL2_c00020	1.659e-47	185.0	COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,25UUV@186806|Eubacteriaceae	186801|Clostridia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
XH1_k127_648318_1	96561.Dole_0184	1.536e-41	158.0	COG1309@1|root,COG1309@2|Bacteria,1Q299@1224|Proteobacteria,42UP4@68525|delta/epsilon subdivisions,2WQF0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
XH1_k127_648318_0	742725.HMPREF9450_01111	4.051e-75	274.0	COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,2FM28@200643|Bacteroidia,22UYZ@171550|Rikenellaceae	976|Bacteroidetes	I	Acyl-CoA dehydrogenase, C-terminal domain	acd	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_dehyd_C
XH1_k127_6516326_0	439235.Dalk_4326	6.162e-117	391.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42QMQ@68525|delta/epsilon subdivisions,2WN4S@28221|Deltaproteobacteria,2MJWK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GGDEF
XH1_k127_6527845_0	395494.Galf_2568	2.123e-94	336.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3290@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,44W7C@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Histidine Phosphotransfer domain	-	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
XH1_k127_6531291_5	5722.XP_001315948.1	2.25e-11	76.0	COG0666@1|root,KOG4177@2759|Eukaryota	5722.XP_001315948.1|-	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_6531291_1	1123392.AQWL01000002_gene1826	8.212e-96	324.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,1KTII@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
XH1_k127_6531291_0	269799.Gmet_3460	3.362e-103	347.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
XH1_k127_6531291_2	247490.KSU1_D0847	1.253e-92	317.0	COG0842@1|root,COG0842@2|Bacteria,2J1QC@203682|Planctomycetes	203682|Planctomycetes	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
XH1_k127_6531291_3	247490.KSU1_D0844	5.328e-86	294.0	COG1131@1|root,COG1131@2|Bacteria,2J23F@203682|Planctomycetes	203682|Planctomycetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
XH1_k127_6531291_4	269799.Gmet_3464	1.911e-49	186.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
XH1_k127_6577966_0	926692.AZYG01000047_gene2647	5.673e-67	234.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,3WAJR@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
XH1_k127_6577966_1	56780.SYN_00272	9.673e-36	137.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria,2MRDH@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Probable molybdopterin binding domain	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
XH1_k127_6603262_2	1410661.JNKW01000009_gene2059	1.815e-68	235.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01704,ko:K20453	ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R10170	RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
XH1_k127_6603262_0	349161.Dred_0286	1.137e-194	614.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,2617C@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
XH1_k127_6603262_1	1121448.DGI_1023	3.874e-82	292.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,43DF9@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,PAS_3,PAS_4,PAS_9
XH1_k127_6610121_0	56780.SYN_01234	2.885e-97	340.0	COG0745@1|root,COG2202@1|root,COG2206@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42QQI@68525|delta/epsilon subdivisions,2X706@28221|Deltaproteobacteria,2MQZA@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg,sCache_2
XH1_k127_6610121_1	56780.SYN_01234	1.611e-82	297.0	COG0745@1|root,COG2202@1|root,COG2206@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42QQI@68525|delta/epsilon subdivisions,2X706@28221|Deltaproteobacteria,2MQZA@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg,sCache_2
XH1_k127_6623288_2	1123257.AUFV01000012_gene3007	2.108e-28	118.0	COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,1RMJH@1236|Gammaproteobacteria,1X44M@135614|Xanthomonadales	135614|Xanthomonadales	M	phospholipase	pldA	-	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110	-	R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	PLA1
XH1_k127_6623288_0	1121451.DESAM_21957	2.391e-49	188.0	COG0834@1|root,COG0834@2|Bacteria,1MZ9S@1224|Proteobacteria	1224|Proteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
XH1_k127_6623288_1	468059.AUHA01000002_gene966	1.687e-30	132.0	COG0330@1|root,COG0330@2|Bacteria,4NFNB@976|Bacteroidetes,1IQR6@117747|Sphingobacteriia	976|Bacteroidetes	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
XH1_k127_6652800_2	515635.Dtur_0752	1.241e-52	191.0	COG0157@1|root,COG0157@2|Bacteria	2|Bacteria	H	quinolinate catabolic process	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1988,iHN637.CLJU_RS12010,iLJ478.TM1645	QRPTase_C,QRPTase_N
XH1_k127_6652800_0	665571.STHERM_c05280	1.187e-249	787.0	COG0556@1|root,COG0556@2|Bacteria,2J57B@203691|Spirochaetes	203691|Spirochaetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
XH1_k127_6652800_1	237368.SCABRO_02835	2.213e-85	287.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,2IZ67@203682|Planctomycetes	203682|Planctomycetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
XH1_k127_6666844_0	1121451.DESAM_21835	1.377e-85	299.0	COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,42Q1K@68525|delta/epsilon subdivisions,2WJ1U@28221|Deltaproteobacteria,2M8XU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glycos_transf_1
XH1_k127_6666844_1	123214.PERMA_1359	3.284e-05	48.0	COG4267@1|root,COG4267@2|Bacteria,2G3TQ@200783|Aquificae	200783|Aquificae	S	Putative exopolysaccharide Exporter (EPS-E)	-	-	-	ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	PelG
XH1_k127_6679798_0	526224.Bmur_1808	3.083e-90	326.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
XH1_k127_6688961_0	1131269.AQVV01000039_gene1536	5.946e-222	704.0	COG0465@1|root,COG0465@2|Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
XH1_k127_6698849_0	909663.KI867150_gene718	5.175e-156	503.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2MRAN@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
XH1_k127_6701566_3	497964.CfE428DRAFT_3684	4.231e-16	81.0	COG0071@1|root,COG0071@2|Bacteria,46WRX@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
XH1_k127_6701566_4	7159.AAEL010216-PA	7.893e-06	57.0	KOG0500@1|root,KOG0500@2759|Eukaryota,38CC1@33154|Opisthokonta,3BAEP@33208|Metazoa,3CUYQ@33213|Bilateria,41UXR@6656|Arthropoda,3SHBX@50557|Insecta,44ZYC@7147|Diptera,45FWT@7148|Nematocera	33208|Metazoa	PT	Cyclic-nucleotide-gated cation channel	-	GO:0003674,GO:0005215,GO:0005216,GO:0005217,GO:0005221,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0007154,GO:0007165,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015276,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0017071,GO:0019932,GO:0019935,GO:0022803,GO:0022832,GO:0022834,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0023052,GO:0030001,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034702,GO:0034703,GO:0035556,GO:0042391,GO:0043855,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099094,GO:1902495,GO:1990351	-	ko:K04949,ko:K04950	ko04024,ko04740,map04024,map04740	-	-	-	ko00000,ko00001,ko04040	1.A.1.5.1,1.A.1.5.12,1.A.1.5.13,1.A.1.5.18,1.A.1.5.20,1.A.1.5.4	-	-	CLZ,Ion_trans,Ion_trans_2,cNMP_binding
XH1_k127_6701566_2	446462.Amir_2137	1.209e-20	96.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4DZA5@85010|Pseudonocardiales	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
XH1_k127_6701566_1	289376.THEYE_A0686	8.748e-30	121.0	COG0846@1|root,COG0846@2|Bacteria,3J15J@40117|Nitrospirae	40117|Nitrospirae	K	Belongs to the sirtuin family. Class	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
XH1_k127_6701566_0	1322246.BN4_12294	2.45e-52	194.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,42QZE@68525|delta/epsilon subdivisions,2WMQH@28221|Deltaproteobacteria,2MB1Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
XH1_k127_6701566_5	243231.GSU1478	5.941e-05	48.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,43S55@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
XH1_k127_6702339_0	1462527.CCDM010000001_gene2771	2.161e-37	143.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,23JGE@182709|Oceanobacillus	91061|Bacilli	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
XH1_k127_6702339_1	158500.BV97_04486	1.13e-10	72.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2TTSK@28211|Alphaproteobacteria,2K969@204457|Sphingomonadales	204457|Sphingomonadales	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
XH1_k127_6712825_1	338966.Ppro_1707	2.356e-113	374.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria,43UBE@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	AIR synthase related protein, C-terminal domain	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
XH1_k127_6712825_0	1121403.AUCV01000022_gene3473	1.168e-126	417.0	COG2199@1|root,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,42NGW@68525|delta/epsilon subdivisions,2WKG6@28221|Deltaproteobacteria,2MMSM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
XH1_k127_6712825_2	880071.Fleli_2820	1.9e-05	51.0	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,47KIF@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
XH1_k127_6712825_3	518766.Rmar_0283	0.0004444	50.0	COG2067@1|root,COG2067@2|Bacteria,4NWE8@976|Bacteroidetes	976|Bacteroidetes	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	PorP_SprF
XH1_k127_6729528_0	868864.Dester_1478	3.439e-56	208.0	COG0142@1|root,COG0142@2|Bacteria,2G3VQ@200783|Aquificae	200783|Aquificae	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
XH1_k127_6729528_1	889378.Spiaf_1940	2.533e-18	86.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4071,GAF,Guanylate_cyc,Pkinase,dCache_1
XH1_k127_6729528_2	478741.JAFS01000001_gene2140	2.841e-13	74.0	COG1664@1|root,COG1664@2|Bacteria,46VS6@74201|Verrucomicrobia,37GTA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
XH1_k127_6748812_1	420247.Msm_1475	9.596e-43	160.0	COG2231@1|root,arCOG00461@2157|Archaea,2Y86S@28890|Euryarchaeota,23PBV@183925|Methanobacteria	183925|Methanobacteria	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
XH1_k127_6748812_0	1379698.RBG1_1C00001G0684	1.508e-128	425.0	COG0277@1|root,COG0277@2|Bacteria,2NP1E@2323|unclassified Bacteria	2|Bacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104,ko:K18930	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
XH1_k127_6750218_0	102125.Xen7305DRAFT_00045680	1.08e-168	547.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1G0KZ@1117|Cyanobacteria,3VHRD@52604|Pleurocapsales	1117|Cyanobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	-	-	-	-	-	-	-	-	-	-	-	-	Chorismate_bind
XH1_k127_6766204_0	61622.XP_010351183.1	5.414e-07	61.0	COG0457@1|root,KOG1126@2759|Eukaryota,38DG8@33154|Opisthokonta,3BENB@33208|Metazoa,3CWDT@33213|Bilateria,482HE@7711|Chordata,491M1@7742|Vertebrata,3J5GW@40674|Mammalia,35F3I@314146|Euarchontoglires,4MQE4@9443|Primates,35Y8E@314294|Cercopithecoidea	33208|Metazoa	D	Cell division cycle	CDC27	GO:0000003,GO:0000151,GO:0000152,GO:0000209,GO:0000278,GO:0000375,GO:0000377,GO:0000398,GO:0001775,GO:0003002,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0006139,GO:0006396,GO:0006397,GO:0006464,GO:0006508,GO:0006511,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0007049,GO:0007088,GO:0007091,GO:0007275,GO:0007338,GO:0007343,GO:0007346,GO:0007389,GO:0008150,GO:0008152,GO:0008283,GO:0008356,GO:0008380,GO:0009056,GO:0009057,GO:0009566,GO:0009798,GO:0009948,GO:0009949,GO:0009952,GO:0009987,GO:0010467,GO:0010498,GO:0010564,GO:0010965,GO:0015630,GO:0016070,GO:0016071,GO:0016192,GO:0016567,GO:0016740,GO:0017156,GO:0019538,GO:0019787,GO:0019899,GO:0019902,GO:0019903,GO:0019941,GO:0019953,GO:0022402,GO:0022414,GO:0030163,GO:0031145,GO:0031461,GO:0031974,GO:0031981,GO:0032446,GO:0032501,GO:0032502,GO:0032940,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034641,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043632,GO:0043900,GO:0043901,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044784,GO:0045055,GO:0046483,GO:0046903,GO:0048519,GO:0048856,GO:0050789,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0051603,GO:0051704,GO:0051726,GO:0051783,GO:0051983,GO:0060467,GO:0060468,GO:0060471,GO:0061630,GO:0061659,GO:0065001,GO:0065007,GO:0070013,GO:0070647,GO:0070979,GO:0071704,GO:0080154,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1903047,GO:1905818,GO:1990234,GO:2000241,GO:2000242	-	ko:K03350	ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map04110,map04111,map04113,map04114,map04120,map04914,map05166	M00389	-	-	ko00000,ko00001,ko00002,ko01009,ko03036,ko04121	-	-	-	ANAPC3,TPR_1,TPR_16,TPR_6,TPR_8
XH1_k127_6783896_0	1094980.Mpsy_0021	6.607e-128	411.0	COG0685@1|root,arCOG04487@2157|Archaea,2XU03@28890|Euryarchaeota,2NAHD@224756|Methanomicrobia	224756|Methanomicrobia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
XH1_k127_6783896_1	237368.SCABRO_00519	5.992e-87	295.0	COG0284@1|root,COG0284@2|Bacteria,2IXSF@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
XH1_k127_6783896_2	1166018.FAES_5028	6.047e-07	52.0	COG2110@1|root,COG2110@2|Bacteria,4NNRH@976|Bacteroidetes,47PZ1@768503|Cytophagia	976|Bacteroidetes	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
XH1_k127_6803704_0	536232.CLM_4031	3.973e-259	836.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,36F91@31979|Clostridiaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
XH1_k127_6821987_0	1313421.JHBV01000041_gene3629	7.126e-100	336.0	COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes	976|Bacteroidetes	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	OmpA,VIT,VWA,VWA_3
XH1_k127_6821987_3	266779.Meso_3350	3.627e-16	86.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2U74E@28211|Alphaproteobacteria,43JE7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	COG2755 Lysophospholipase L1 and related	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
XH1_k127_6821987_2	545695.TREAZ_0766	1.572e-33	132.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
XH1_k127_6821987_1	545695.TREAZ_0766	1.353e-70	248.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
XH1_k127_6824774_2	1121904.ARBP01000001_gene5804	2.412e-07	62.0	COG4191@1|root,COG4191@2|Bacteria,4NE4T@976|Bacteroidetes,47K96@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
XH1_k127_6824774_0	243231.GSU3374	1.701e-87	294.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,43U38@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
XH1_k127_6824774_1	335543.Sfum_4051	1.808e-15	78.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
XH1_k127_6847695_1	744872.Spica_2538	2.899e-58	209.0	COG0601@1|root,COG0601@2|Bacteria,2J601@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter, permease protein	oppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
XH1_k127_6847695_0	1031288.AXAA01000014_gene358	1.869e-144	474.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,36EHU@31979|Clostridiaceae	186801|Clostridia	E	Family 5	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
XH1_k127_6864831_2	665571.STHERM_c06700	1.95e-21	102.0	2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
XH1_k127_6864831_0	573413.Spirs_2144	6.894e-285	896.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
XH1_k127_6864831_1	243231.GSU3102	7.948e-136	444.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,43TD6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
XH1_k127_6864831_3	526224.Bmur_1339	2.866e-12	66.0	COG4786@1|root,COG4786@2|Bacteria,2J5EJ@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein	flhO	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
XH1_k127_6866928_0	1191523.MROS_2695	7.644e-168	537.0	COG0015@1|root,COG0015@2|Bacteria	2|Bacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1095,iSB619.SA_RS09895	ADSL_C,Lyase_1
XH1_k127_6866928_1	1449126.JQKL01000001_gene1497	2.986e-06	50.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,267II@186813|unclassified Clostridiales	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
XH1_k127_6904350_0	1031288.AXAA01000005_gene2013	6.351e-234	734.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
XH1_k127_6958401_0	580327.Tthe_0971	2.754e-63	219.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia,42FMG@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
XH1_k127_6958401_2	935948.KE386495_gene2048	5.013e-47	179.0	COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,42FEU@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid	tarA	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,PS_pyruv_trans
XH1_k127_6958401_1	1265505.ATUG01000001_gene3109	1.081e-52	202.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2MIMK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
XH1_k127_6976031_0	903818.KI912268_gene2932	3.086e-203	646.0	COG1061@1|root,COG1061@2|Bacteria	2|Bacteria	L	Type III restriction enzyme res subunit	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
XH1_k127_6976031_1	1385935.N836_30995	0.0003878	50.0	COG4447@1|root,COG4447@2|Bacteria,1G2KP@1117|Cyanobacteria,1H6WW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
XH1_k127_6988160_0	1379698.RBG1_1C00001G1642	7.474e-89	300.0	COG0029@1|root,COG0029@2|Bacteria,2NNMD@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.3.5.4,1.4.3.16	ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00115,M00150,M00173	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899	FAD_binding_2,Succ_DH_flav_C
XH1_k127_6988160_1	1121405.dsmv_1250	2.383e-29	118.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42RB9@68525|delta/epsilon subdivisions,2WMPE@28221|Deltaproteobacteria,2MJPY@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ferritin-like domain	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
XH1_k127_7014464_0	1499967.BAYZ01000103_gene3741	3.686e-95	332.0	COG1032@1|root,COG1032@2|Bacteria,2NQ35@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
XH1_k127_7020807_0	555079.Toce_2181	3.338e-202	642.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
XH1_k127_7024038_0	56780.SYN_00664	1.164e-133	437.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,Pyridoxal_deC
XH1_k127_7066822_1	696281.Desru_3353	4.819e-26	115.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,260BS@186807|Peptococcaceae	186801|Clostridia	M	TIGRFAM stage V sporulation protein D	spoVD	-	-	ko:K08384	ko00550,map00550	-	-	-	ko00000,ko00001,ko01011	-	-	-	PASTA,PBP_dimer,Transpeptidase
XH1_k127_7066822_0	526224.Bmur_1917	1.294e-43	172.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
XH1_k127_7080957_0	1033733.CAEK01000013_gene340	5.767e-66	235.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,22GDB@1570339|Peptoniphilaceae	186801|Clostridia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
XH1_k127_7080957_1	572547.Amico_1475	2.683e-52	196.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,3T9T4@508458|Synergistetes	508458|Synergistetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
XH1_k127_7111761_1	1232437.KL662010_gene1631	3.024e-71	249.0	28I4Y@1|root,2Z88D@2|Bacteria,1R95V@1224|Proteobacteria,42RX3@68525|delta/epsilon subdivisions,2WMGE@28221|Deltaproteobacteria,2MJ0V@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7111761_0	401526.TcarDRAFT_0626	4.908e-90	308.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,4H2S4@909932|Negativicutes	2|Bacteria	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
XH1_k127_7111761_4	237368.SCABRO_02485	4.849e-29	121.0	COG0745@1|root,COG0745@2|Bacteria	237368.SCABRO_02485|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7111761_2	338966.Ppro_2783	7.068e-68	235.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WNT3@28221|Deltaproteobacteria	1224|Proteobacteria	C	Belongs to the complex I 20 kDa subunit family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
XH1_k127_7111761_3	338966.Ppro_2784	2.835e-49	181.0	COG1143@1|root,COG1143@2|Bacteria,1R9YT@1224|Proteobacteria,42P0W@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hyfH	-	-	ko:K12143,ko:K15831	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_3805,iECABU_c1320.ECABU_c29910,iECED1_1282.ECED1_3171,iECOK1_1307.ECOK1_3094,iUMN146_1321.UM146_02980,iUTI89_1310.UTI89_C3083,ic_1306.c3280	Fer4,Fer4_7
XH1_k127_7133387_1	1042375.AFPL01000055_gene2269	2.984e-21	93.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,4689Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
XH1_k127_7133387_0	1144342.PMI40_00431	8.371e-30	133.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,473G0@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
XH1_k127_7187947_0	909663.KI867150_gene602	4.519e-46	172.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2WP66@28221|Deltaproteobacteria,2MRU5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
XH1_k127_7187947_1	1499967.BAYZ01000152_gene1436	4.519e-05	48.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2NPAA@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
XH1_k127_7195238_2	161156.JQKW01000009_gene1503	1.479e-05	50.0	COG0457@1|root,COG0457@2|Bacteria,2GHBM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
XH1_k127_7195238_1	545695.TREAZ_3287	1.623e-84	294.0	COG0618@1|root,COG0618@2|Bacteria,2J6ZI@203691|Spirochaetes	203691|Spirochaetes	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH
XH1_k127_7195238_0	744872.Spica_1382	1.818e-91	308.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
XH1_k127_7203481_2	1168289.AJKI01000027_gene1329	2.902e-10	61.0	COG4623@1|root,COG4623@2|Bacteria,4NHFW@976|Bacteroidetes,2FN2R@200643|Bacteroidia,3XJUD@558415|Marinilabiliaceae	976|Bacteroidetes	M	Bacterial periplasmic substrate-binding proteins	mltF	-	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
XH1_k127_7203481_1	1173020.Cha6605_1944	1.895e-36	144.0	COG0716@1|root,COG0716@2|Bacteria,1G55J@1117|Cyanobacteria	1117|Cyanobacteria	C	Low-potential electron donor to a number of redox enzymes	-	-	-	ko:K03839	-	-	-	-	ko00000	-	-	-	Flavodoxin_1
XH1_k127_7203481_0	926562.Oweho_0457	2.743e-81	290.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,4NEVN@976|Bacteroidetes,1HYQY@117743|Flavobacteriia,2PBN1@246874|Cryomorphaceae	976|Bacteroidetes	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_12,TPR_8
XH1_k127_7262766_1	1216362.B437_07457	2.061e-85	290.0	COG0173@1|root,COG0173@2|Bacteria,37982@32066|Fusobacteria	32066|Fusobacteria	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA-synt_2d,tRNA_anti-codon
XH1_k127_7262766_0	350688.Clos_1246	6.368e-92	312.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,36UI2@31979|Clostridiaceae	186801|Clostridia	T	PhoH-like protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
XH1_k127_7262766_2	1415775.U729_37	1.176e-08	66.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,36E2C@31979|Clostridiaceae	186801|Clostridia	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
XH1_k127_7264431_1	909663.KI867150_gene1507	1.205e-126	410.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,2MRP7@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
XH1_k127_7264431_0	909663.KI867150_gene1506	4.818e-243	755.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,42NFZ@68525|delta/epsilon subdivisions,2WMBX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
XH1_k127_7264431_2	909663.KI867150_gene2949	2.435e-69	237.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
XH1_k127_7266384_1	748449.Halha_1245	7.414e-26	107.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
XH1_k127_7266384_0	521674.Plim_1152	4.564e-101	347.0	COG0793@1|root,COG0793@2|Bacteria,2IXI9@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
XH1_k127_7268583_2	13333.ERN13056	2.389e-05	53.0	COG3914@1|root,KOG4626@2759|Eukaryota,37IV9@33090|Viridiplantae,3G9DX@35493|Streptophyta	35493|Streptophyta	GOT	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY	SPY	GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0007154,GO:0007165,GO:0008150,GO:0008194,GO:0008375,GO:0009719,GO:0009725,GO:0009735,GO:0009736,GO:0009739,GO:0009740,GO:0009755,GO:0009937,GO:0009938,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010476,GO:0010646,GO:0010648,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0019222,GO:0023051,GO:0023052,GO:0023057,GO:0031323,GO:0032870,GO:0033993,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071310,GO:0071368,GO:0071370,GO:0071396,GO:0071495,GO:0140096,GO:1901700,GO:1901701,GO:2000377	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_10,TPR_16,TPR_7,TPR_8
XH1_k127_7268583_0	1056495.Calag_0300	1.391e-45	169.0	arCOG05276@1|root,arCOG05276@2157|Archaea,2XS11@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7268583_1	706587.Desti_4721	8.187e-15	79.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7275742_0	316274.Haur_2958	5.186e-35	144.0	COG1502@1|root,COG1502@2|Bacteria,2G8RC@200795|Chloroflexi,37519@32061|Chloroflexia	32061|Chloroflexia	I	PFAM phospholipase D Transphosphatidylase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
XH1_k127_7285711_2	555779.Dthio_PD3581	2.171e-11	76.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,42Q3U@68525|delta/epsilon subdivisions,2WJ18@28221|Deltaproteobacteria,2M9ZX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7285711_4	118161.KB235922_gene3958	1.675e-09	63.0	COG1366@1|root,COG1366@2|Bacteria,1G7WI@1117|Cyanobacteria,3VMXD@52604|Pleurocapsales	1117|Cyanobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
XH1_k127_7285711_3	1123274.KB899409_gene539	1.032e-09	71.0	COG1652@1|root,COG1652@2|Bacteria,2J7QX@203691|Spirochaetes	203691|Spirochaetes	S	Treponemal membrane protein	tmpB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LysM
XH1_k127_7285711_1	1321815.HMPREF9193_00821	7.601e-24	104.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
XH1_k127_7285711_0	340099.Teth39_1017	6.91e-128	418.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,42EMN@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
XH1_k127_7289931_3	113395.AXAI01000033_gene641	6.321e-11	67.0	COG0789@1|root,COG0789@2|Bacteria,1N831@1224|Proteobacteria,2UFMB@28211|Alphaproteobacteria,3JZYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
XH1_k127_7289931_1	698761.RTCIAT899_CH05300	2.691e-73	257.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,4B8Z7@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	DnaJ C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
XH1_k127_7289931_2	317936.Nos7107_3521	7.483e-37	144.0	2BK9M@1|root,32EPT@2|Bacteria,1G703@1117|Cyanobacteria,1HS5Z@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7289931_5	696281.Desru_3478	1.618e-07	57.0	2AJ5R@1|root,319QC@2|Bacteria,1W52E@1239|Firmicutes,257GF@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7289931_0	526224.Bmur_2822	1.39e-177	559.0	COG0191@1|root,COG0191@2|Bacteria,2J5IR@203691|Spirochaetes	203691|Spirochaetes	G	aldolase class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
XH1_k127_7301125_2	1123274.KB899419_gene1998	1.087e-17	85.0	2C5UX@1|root,33TSC@2|Bacteria,2J5VA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7301125_1	158190.SpiGrapes_1145	1.497e-70	247.0	COG0584@1|root,COG0584@2|Bacteria,2J689@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
XH1_k127_7301125_0	935948.KE386494_gene710	9.689e-86	293.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,42EKM@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
XH1_k127_7301279_5	1341157.RF007C_09870	4.165e-05	46.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,3WKU1@541000|Ruminococcaceae	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
XH1_k127_7301279_4	879212.DespoDRAFT_01384	6.552e-21	96.0	COG0764@1|root,COG0764@2|Bacteria,1NNU2@1224|Proteobacteria,437EX@68525|delta/epsilon subdivisions,2X2M8@28221|Deltaproteobacteria,2MP7V@213118|Desulfobacterales	28221|Deltaproteobacteria	I	FabA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	FabA
XH1_k127_7301279_3	1121396.KB892935_gene3845	2.856e-32	127.0	COG0236@1|root,COG0236@2|Bacteria,1P23P@1224|Proteobacteria,4320N@68525|delta/epsilon subdivisions,2WWEE@28221|Deltaproteobacteria,2MNVC@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
XH1_k127_7301279_2	1121403.AUCV01000014_gene4633	4.274e-161	514.0	COG0535@1|root,COG0535@2|Bacteria,1NDQM@1224|Proteobacteria,42YEG@68525|delta/epsilon subdivisions,2WUNR@28221|Deltaproteobacteria,2MMSQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7301279_0	1121403.AUCV01000014_gene4632	9.691e-184	577.0	COG0535@1|root,COG0535@2|Bacteria,1R6IV@1224|Proteobacteria,42YE7@68525|delta/epsilon subdivisions,2WU7H@28221|Deltaproteobacteria,2MMU0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12
XH1_k127_7301279_1	1121403.AUCV01000014_gene4631	1.082e-176	562.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42YVN@68525|delta/epsilon subdivisions,2WU2B@28221|Deltaproteobacteria,2MMVP@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
XH1_k127_7306915_1	1111730.ATTM01000002_gene1231	0.0003243	52.0	COG1566@1|root,COG1566@2|Bacteria,4PKPZ@976|Bacteroidetes,1I071@117743|Flavobacteriia,2NVFX@237|Flavobacterium	976|Bacteroidetes	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
XH1_k127_7306915_0	665571.STHERM_c09210	6.344e-39	153.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
XH1_k127_7313218_1	1313304.CALK_1286	1.638e-38	146.0	COG1155@1|root,COG1155@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
XH1_k127_7313218_0	1313304.CALK_1285	1.053e-234	731.0	COG1156@1|root,COG1156@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
XH1_k127_7313218_2	1313304.CALK_1284	2.376e-11	66.0	COG1394@1|root,COG1394@2|Bacteria	2|Bacteria	C	ATPase activity, coupled to transmembrane movement of substances	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
XH1_k127_7324473_0	656519.Halsa_1855	3.789e-91	310.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,3WA6G@53433|Halanaerobiales	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
XH1_k127_7324473_1	316067.Geob_2654	5.545e-82	289.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,43TEQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
XH1_k127_7329119_1	595494.Tola_1404	4.425e-54	193.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH1_k127_7329119_2	1173027.Mic7113_2452	1.365e-52	189.0	COG0745@1|root,COG0745@2|Bacteria,1G79X@1117|Cyanobacteria,1HBKY@1150|Oscillatoriales	1117|Cyanobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
XH1_k127_7329119_0	643562.Daes_0359	1.676e-58	220.0	COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,43CZY@68525|delta/epsilon subdivisions,2X887@28221|Deltaproteobacteria,2MHCZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
XH1_k127_7336437_1	273068.TTE1280	1.355e-33	139.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,42F13@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM peptidase M24	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
XH1_k127_7336437_0	1408422.JHYF01000001_gene2818	6.94e-53	190.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,36JJ0@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
XH1_k127_7336437_2	1121931.AUHG01000011_gene1914	7.195e-13	83.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia	976|Bacteroidetes	K	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
XH1_k127_7354096_0	1307761.L21SP2_0313	6.793e-54	194.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
XH1_k127_7354096_1	1480694.DC28_06805	1.784e-46	186.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
XH1_k127_7354096_2	1480694.DC28_06810	4.89e-18	98.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
XH1_k127_7360614_1	1304872.JAGC01000003_gene2679	1.963e-37	162.0	COG2203@1|root,COG3829@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2WPBU@28221|Deltaproteobacteria,2MA5B@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Membrane-associated sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,MASE3,NMT1,PAS_4,PAS_9,SBP_bac_3,dCache_1
XH1_k127_7360614_0	56780.SYN_02213	3.431e-141	476.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
XH1_k127_7363035_1	913865.DOT_1621	6.397e-112	375.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
XH1_k127_7363035_0	330214.NIDE4127	4.451e-231	734.0	COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae	40117|Nitrospirae	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
XH1_k127_7363035_3	1449126.JQKL01000001_gene1385	1.337e-32	128.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
XH1_k127_7363035_2	1487921.DP68_06530	4.806e-56	207.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,36EJJ@31979|Clostridiaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
XH1_k127_7363035_4	240302.BN982_02003	1.005e-19	93.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,3NF00@45667|Halobacillus	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
XH1_k127_7371822_0	269797.Mbar_A2562	1.3e-78	271.0	COG1122@1|root,arCOG00202@2157|Archaea,2XVRT@28890|Euryarchaeota,2N9CJ@224756|Methanomicrobia	224756|Methanomicrobia	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
XH1_k127_7371822_1	1265505.ATUG01000003_gene280	8.546e-40	156.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria,2MJWH@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
XH1_k127_7379771_0	1123371.ATXH01000009_gene1107	3.966e-148	480.0	COG0172@1|root,COG0172@2|Bacteria,2GGY4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
XH1_k127_7382610_1	1122947.FR7_4245	2.414e-41	165.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4H4HE@909932|Negativicutes	909932|Negativicutes	M	Peptidase, M23 family	envC_2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
XH1_k127_7382610_0	1304885.AUEY01000049_gene1220	3.594e-112	374.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,2MHZV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
XH1_k127_7384491_2	1121382.JQKG01000011_gene563	2.731e-05	51.0	2DSAC@1|root,32USM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7384491_0	398767.Glov_2241	1.12e-139	453.0	COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,42N3V@68525|delta/epsilon subdivisions,2WVM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glutathionylspermidine synthase preATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	GSP_synth
XH1_k127_7384491_1	398767.Glov_2240	7.546e-36	141.0	COG3766@1|root,COG3766@2|Bacteria,1N14W@1224|Proteobacteria,42SKF@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Domain of Unknown Function (DUF350)	yjfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08989	-	-	-	-	ko00000	-	-	-	DUF350
XH1_k127_7394709_0	795359.TOPB45_0864	1.276e-92	316.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
XH1_k127_7394709_1	795359.TOPB45_0865	9.68e-53	201.0	COG0419@1|root,COG0419@2|Bacteria,2GI5T@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	-
XH1_k127_7410521_2	1121948.AUAC01000002_gene1215	1.21e-25	110.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2V77P@28211|Alphaproteobacteria,43ZAS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7410521_3	313624.NSP_16150	6.187e-16	89.0	COG1409@1|root,COG1413@1|root,COG5635@1|root,COG1409@2|Bacteria,COG1413@2|Bacteria,COG5635@2|Bacteria,1G233@1117|Cyanobacteria,1HJ1W@1161|Nostocales	1117|Cyanobacteria	CT	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,NB-ARC,Peptidase_C14
XH1_k127_7410521_1	1163407.UU7_13123	4.22e-73	249.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S2NX@1236|Gammaproteobacteria,1XCVM@135614|Xanthomonadales	135614|Xanthomonadales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
XH1_k127_7410521_0	909663.KI867150_gene2906	6.675e-75	254.0	COG5423@1|root,COG5423@2|Bacteria,1QP40@1224|Proteobacteria,4377T@68525|delta/epsilon subdivisions,2X9VH@28221|Deltaproteobacteria,2MS6N@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
XH1_k127_7410521_4	913865.DOT_2035	3.09e-11	68.0	COG3339@1|root,COG3339@2|Bacteria,1VAM6@1239|Firmicutes,24KQN@186801|Clostridia,2637V@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
XH1_k127_7429525_1	720554.Clocl_4116	3.417e-25	107.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
XH1_k127_7429525_0	1267535.KB906767_gene3177	1.457e-204	645.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria,2JHRC@204432|Acidobacteriia	204432|Acidobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
XH1_k127_7434606_0	203119.Cthe_2141	1.255e-13	72.0	COG0232@1|root,COG0232@2|Bacteria,1UYDF@1239|Firmicutes,24CBV@186801|Clostridia,3WJ29@541000|Ruminococcaceae	186801|Clostridia	F	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
XH1_k127_7439844_1	909663.KI867150_gene881	1.696e-25	107.0	COG1001@1|root,COG1001@2|Bacteria,1MVFP@1224|Proteobacteria,42NWX@68525|delta/epsilon subdivisions,2WIZY@28221|Deltaproteobacteria,2MQ8T@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	-	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
XH1_k127_7439844_2	933262.AXAM01000015_gene97	2.959e-07	62.0	COG3170@1|root,COG3170@2|Bacteria,1NHGQ@1224|Proteobacteria,42X64@68525|delta/epsilon subdivisions,2WSMQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF2275,zf-HC2
XH1_k127_7439844_0	933262.AXAM01000015_gene98	1.29e-53	194.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2MKZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
XH1_k127_7447004_0	1131269.AQVV01000017_gene1969	1.507e-253	803.0	COG0458@1|root,COG1304@1|root,COG0458@2|Bacteria,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	lldD	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,FMN_dh
XH1_k127_7495495_0	1304284.L21TH_2683	4.896e-159	520.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,36F97@31979|Clostridiaceae	186801|Clostridia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
XH1_k127_7495495_2	56780.SYN_02934	1.982e-36	144.0	COG0622@1|root,COG0622@2|Bacteria,1N8BH@1224|Proteobacteria,42VEB@68525|delta/epsilon subdivisions,2WRII@28221|Deltaproteobacteria,2MS3U@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
XH1_k127_7495495_1	1121405.dsmv_0171	1.449e-41	156.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria,2MI96@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
XH1_k127_7498641_1	1034347.CAHJ01000065_gene2995	1.737e-37	156.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,4HBV6@91061|Bacilli,1ZCMY@1386|Bacillus	91061|Bacilli	T	HD domain	cnpD3	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
XH1_k127_7498641_2	1499967.BAYZ01000105_gene3534	9.308e-14	76.0	2C914@1|root,32T2A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7498641_0	748727.CLJU_c04060	7.863e-94	313.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,36E5D@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the methyltransferase superfamily	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
XH1_k127_7524820_2	338963.Pcar_1721	2.055e-15	78.0	COG1977@1|root,COG1977@2|Bacteria,1QRAS@1224|Proteobacteria,43EYG@68525|delta/epsilon subdivisions,2X2KE@28221|Deltaproteobacteria,43VWD@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
XH1_k127_7524820_1	933262.AXAM01000015_gene100	9.809e-36	143.0	2E1K2@1|root,32WXJ@2|Bacteria,1N3MI@1224|Proteobacteria,42UCI@68525|delta/epsilon subdivisions,2WR06@28221|Deltaproteobacteria,2MM58@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7524820_0	1232410.KI421422_gene1975	8.403e-105	343.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,43UGJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
XH1_k127_7555091_1	457424.BFAG_03055	9.863e-15	81.0	COG2208@1|root,COG4753@1|root,COG2208@2|Bacteria,COG4753@2|Bacteria,4PM3Q@976|Bacteroidetes,2G2UW@200643|Bacteroidia,4AW55@815|Bacteroidaceae	976|Bacteroidetes	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
XH1_k127_7555091_0	1379698.RBG1_1C00001G0370	4.654e-22	109.0	COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
XH1_k127_7555259_0	316067.Geob_2294	6.968e-188	597.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,42MJX@68525|delta/epsilon subdivisions,2WJDM@28221|Deltaproteobacteria,43TMW@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	PFAM tRNA synthetase, class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
XH1_k127_7555259_1	1278073.MYSTI_04729	2.883e-27	126.0	COG4249@1|root,COG4249@2|Bacteria,1QX7K@1224|Proteobacteria,43AHW@68525|delta/epsilon subdivisions,2X5Y0@28221|Deltaproteobacteria,2YZCA@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
XH1_k127_7557854_1	243275.TDE_2661	7.758e-15	76.0	COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes	203691|Spirochaetes	S	FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
XH1_k127_7557854_2	759914.BP951000_1308	2.995e-14	76.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	iscA1	-	6.3.5.11,6.3.5.9	ko:K02224,ko:K13628,ko:K15724	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000,ko03016	-	-	-	Fe-S_biosyn
XH1_k127_7557854_0	443144.GM21_0831	2.407e-16	92.0	COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42SGU@68525|delta/epsilon subdivisions,2WPBP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin)	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
XH1_k127_7560771_1	1480694.DC28_11645	1.753e-28	121.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
XH1_k127_7560771_0	889378.Spiaf_2848	1.147e-69	250.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2,zinc_ribbon_2
XH1_k127_7566273_0	555079.Toce_0947	9.641e-108	361.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,42ETI@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
XH1_k127_7566273_1	665952.HMPREF1015_01992	1.925e-81	286.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli,1ZCC3@1386|Bacillus	91061|Bacilli	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
XH1_k127_757106_0	1122165.AUHS01000013_gene26	5.413e-92	315.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1JCUW@118969|Legionellales	118969|Legionellales	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
XH1_k127_757106_1	443144.GM21_1780	1.484e-52	199.0	COG2385@1|root,COG2385@2|Bacteria,1RGJS@1224|Proteobacteria,42RZE@68525|delta/epsilon subdivisions,2WNH8@28221|Deltaproteobacteria,43TQU@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	PFAM Stage II sporulation	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
XH1_k127_7592455_1	1499967.BAYZ01000103_gene3739	3.444e-25	105.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE,TusA
XH1_k127_7592455_2	1499967.BAYZ01000103_gene3737	7.432e-15	77.0	COG0822@1|root,COG0822@2|Bacteria	2|Bacteria	C	iron-sulfur transferase activity	-	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	DUF3343,Fer2_BFD,NifU,NifU_N
XH1_k127_7592455_0	1265505.ATUG01000001_gene4625	2.056e-217	677.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria,2MHYP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
XH1_k127_7621549_0	1294142.CINTURNW_2876	3.478e-85	301.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,36DF6@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
XH1_k127_7628819_0	1278309.KB907099_gene2448	5.996e-202	638.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1XHR7@135619|Oceanospirillales	135619|Oceanospirillales	E	phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
XH1_k127_7628819_1	1121405.dsmv_0825	3.188e-100	332.0	COG0123@1|root,COG0123@2|Bacteria,1RBR4@1224|Proteobacteria,42R2Z@68525|delta/epsilon subdivisions,2WN6H@28221|Deltaproteobacteria,2MN17@213118|Desulfobacterales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
XH1_k127_7628819_2	903818.KI912268_gene2901	1.906e-67	233.0	COG1981@1|root,COG1981@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2269
XH1_k127_7628819_3	509191.AEDB02000063_gene470	2.199e-43	165.0	COG2199@1|root,COG3706@2|Bacteria,1VADD@1239|Firmicutes,25E7Q@186801|Clostridia,3WM5H@541000|Ruminococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	2.7.7.65	ko:K21022	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GAF_2,GAF_3,GGDEF,PAS_9
XH1_k127_7640180_1	1223410.KN050846_gene1327	1.16e-06	59.0	COG0457@1|root,COG0457@2|Bacteria,4NG9G@976|Bacteroidetes,1HYXF@117743|Flavobacteriia	976|Bacteroidetes	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8
XH1_k127_7640180_0	1537915.JU57_03955	6.9e-14	79.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,42T06@68525|delta/epsilon subdivisions,2YPIQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_16,TPR_2,TPR_8
XH1_k127_7644052_2	401526.TcarDRAFT_1972	3.861e-66	233.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,4H2ZQ@909932|Negativicutes	909932|Negativicutes	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
XH1_k127_7644052_1	56780.SYN_00998	1.989e-104	351.0	COG1032@1|root,COG1032@2|Bacteria,1PTN9@1224|Proteobacteria,42MG9@68525|delta/epsilon subdivisions,2WJYU@28221|Deltaproteobacteria,2MR0G@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH1_k127_7644052_0	373903.Hore_00750	1.667e-176	567.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,3WAA0@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
XH1_k127_7652229_0	1379698.RBG1_1C00001G1556	1.341e-62	229.0	COG0389@1|root,COG0389@2|Bacteria,2NP5S@2323|unclassified Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
XH1_k127_7652229_2	1122621.ATZA01000020_gene4014	6.243e-51	185.0	COG0245@1|root,COG0245@2|Bacteria,4NP0N@976|Bacteroidetes,1IS13@117747|Sphingobacteriia	976|Bacteroidetes	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
XH1_k127_7652229_1	1191523.MROS_1662	2.64e-54	196.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
XH1_k127_7659551_3	215803.DB30_3939	2.529e-17	83.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01165	ATP-synt_C
XH1_k127_7659551_1	517418.Ctha_1380	1.407e-27	118.0	COG0711@1|root,COG0711@2|Bacteria,1FDW3@1090|Chlorobi	1090|Chlorobi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
XH1_k127_7659551_2	1035196.HMPREF9998_01507	6.067e-18	91.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,25RIK@186804|Peptostreptococcaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
XH1_k127_7659551_0	344747.PM8797T_28844	3.885e-216	681.0	COG0056@1|root,COG0056@2|Bacteria,2IXN5@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
XH1_k127_7684136_0	224324.aq_2196	6.764e-56	201.0	COG1912@1|root,COG1912@2|Bacteria,2G44H@200783|Aquificae	200783|Aquificae	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
XH1_k127_7712953_0	909663.KI867150_gene2072	1.2e-202	639.0	COG0591@1|root,COG0591@2|Bacteria,1PGM9@1224|Proteobacteria,43A2A@68525|delta/epsilon subdivisions,2WT1A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
XH1_k127_7712953_1	706587.Desti_4230	2.126e-106	350.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,42TEX@68525|delta/epsilon subdivisions,2WPG8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
XH1_k127_7725055_0	290402.Cbei_0475	3.326e-13	81.0	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia,36FXK@31979|Clostridiaceae	186801|Clostridia	L	DNA repair exonuclease	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
XH1_k127_7740493_6	1121289.JHVL01000002_gene2331	1.202e-08	59.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,36FGF@31979|Clostridiaceae	186801|Clostridia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
XH1_k127_7740493_1	1278306.KB906908_gene588	1.306e-60	220.0	COG0774@1|root,COG0774@2|Bacteria,3794N@32066|Fusobacteria	32066|Fusobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
XH1_k127_7740493_5	1121104.AQXH01000001_gene1326	3.13e-32	135.0	292MF@1|root,30IPY@2|Bacteria,4P6CM@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
XH1_k127_7740493_4	56780.SYN_00318	2.635e-56	203.0	COG0491@1|root,COG0491@2|Bacteria,1RJQM@1224|Proteobacteria,42SK3@68525|delta/epsilon subdivisions,2WPR1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
XH1_k127_7740493_0	439235.Dalk_3322	3.919e-84	293.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WJS7@28221|Deltaproteobacteria,2MIWA@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
XH1_k127_7740493_2	754027.HMPREF9554_00730	5.97e-60	219.0	COG2199@1|root,COG3706@2|Bacteria,2J5S2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
XH1_k127_7740493_3	596324.TREVI0001_0495	7.173e-59	216.0	COG0664@1|root,COG2199@1|root,COG0664@2|Bacteria,COG3706@2|Bacteria,2J6RG@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
XH1_k127_7752433_2	648996.Theam_0136	2.18e-91	303.0	COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae	200783|Aquificae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
XH1_k127_7752433_1	555079.Toce_1766	1.667e-175	559.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,42EU3@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
XH1_k127_7752433_0	1121430.JMLG01000002_gene1011	3.186e-185	591.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,260BY@186807|Peptococcaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
XH1_k127_7753364_0	378806.STAUR_6512	6.906e-93	325.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,43AH9@68525|delta/epsilon subdivisions,2X5XB@28221|Deltaproteobacteria,2Z37F@29|Myxococcales	28221|Deltaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
XH1_k127_7763674_0	575590.HMPREF0156_00848	5.213e-32	138.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
XH1_k127_7775380_2	335543.Sfum_3215	4.576e-21	94.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria,2MR86@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
XH1_k127_7775380_0	933262.AXAM01000007_gene2055	1.899e-115	377.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42NS5@68525|delta/epsilon subdivisions,2WNQ5@28221|Deltaproteobacteria,2MJ7B@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
XH1_k127_7775380_1	1121104.AQXH01000001_gene2061	2.24e-52	188.0	COG0501@1|root,COG0501@2|Bacteria,4NESF@976|Bacteroidetes	976|Bacteroidetes	O	Zn-dependent protease with chaperone function	-	-	3.4.24.84	ko:K03799,ko:K06013	ko00900,ko01130,map00900,map01130	M00743	R09845	RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
XH1_k127_7778229_0	1480694.DC28_01695	2.237e-104	355.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
XH1_k127_7778229_1	1307761.L21SP2_1779	2.374e-94	324.0	COG0772@1|root,COG0772@2|Bacteria,2J62H@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family. MrdB RodA subfamily	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
XH1_k127_7778229_2	1122169.AREN01000011_gene1595	5.895e-18	87.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1JC8U@118969|Legionellales	118969|Legionellales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
XH1_k127_7783013_0	56780.SYN_02382	1.345e-236	737.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MR9X@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
XH1_k127_7794459_0	357808.RoseRS_2905	1.747e-91	327.0	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi,3765Y@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	ko:K15314	ko01059,ko01130,map01059,map01130	M00824,M00825	R11435	-	ko00000,ko00001,ko00002,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
XH1_k127_7794459_1	706587.Desti_1510	2.477e-19	98.0	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG2070@1|root,COG2977@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG2070@2|Bacteria,COG2977@2|Bacteria,COG3321@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
XH1_k127_7803598_2	96561.Dole_0210	2.551e-55	199.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MC0@68525|delta/epsilon subdivisions,2WJIC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25,3.6.3.29,3.6.3.55	ko:K02017,ko:K02045,ko:K15497	ko00920,ko02010,map00920,map02010	M00185,M00189,M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE_2,TOBE_3
XH1_k127_7803598_1	96561.Dole_0209	3.664e-61	220.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,43DX8@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
XH1_k127_7803598_0	96561.Dole_0208	9.783e-92	309.0	COG0725@1|root,COG0725@2|Bacteria,1QD9D@1224|Proteobacteria,42QRE@68525|delta/epsilon subdivisions,2WMW0@28221|Deltaproteobacteria,2MK56@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
XH1_k127_7803598_3	573413.Spirs_1024	2.486e-16	81.0	COG2005@1|root,COG2005@2|Bacteria,2J95X@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
XH1_k127_7819814_0	56780.SYN_01378	9.255e-92	307.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,2MQBN@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1885	PdxJ
XH1_k127_7819814_3	545697.HMPREF0216_00743	2.072e-08	65.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,36FAH@31979|Clostridiaceae	186801|Clostridia	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
XH1_k127_7819814_2	1347086.CCBA010000046_gene2480	6.157e-60	216.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,1ZBIU@1386|Bacillus	91061|Bacilli	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
XH1_k127_7819814_1	289376.THEYE_A0627	1.968e-88	299.0	COG0294@1|root,COG0294@2|Bacteria,3J0NS@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
XH1_k127_7839116_2	378806.STAUR_3193	4.132e-33	136.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales	28221|Deltaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
XH1_k127_7839116_0	1232410.KI421418_gene2157	2.579e-176	569.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43UCA@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
XH1_k127_7839116_1	1121441.AUCX01000020_gene655	8.593e-55	204.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2M98X@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	PFAM type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
XH1_k127_7864354_0	468059.AUHA01000002_gene606	4.023e-107	355.0	COG2256@1|root,COG2256@2|Bacteria,4NEV8@976|Bacteroidetes,1IPEJ@117747|Sphingobacteriia	976|Bacteroidetes	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
XH1_k127_7864354_1	224324.aq_1907	3.298e-50	184.0	COG0461@1|root,COG0461@2|Bacteria,2G4DW@200783|Aquificae	200783|Aquificae	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
XH1_k127_7886665_1	945713.IALB_1030	2.909e-89	301.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	nagB	-	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
XH1_k127_7886665_0	1307761.L21SP2_0076	2.667e-131	442.0	COG0448@1|root,COG0448@2|Bacteria,2JBCU@203691|Spirochaetes	203691|Spirochaetes	G	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
XH1_k127_7886665_2	96561.Dole_2244	1.691e-61	215.0	arCOG05253@1|root,31CTK@2|Bacteria,1RIYS@1224|Proteobacteria,42T7T@68525|delta/epsilon subdivisions,2WP9R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_7886665_5	1121004.ATVC01000013_gene2055	5.002e-29	122.0	COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,2VR5T@28216|Betaproteobacteria,2KRGT@206351|Neisseriales	206351|Neisseriales	S	thioesterase K01075	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
XH1_k127_7886665_4	453591.Igni_1099	9.187e-35	138.0	COG0537@1|root,arCOG00419@2157|Archaea,2XQZ7@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
XH1_k127_7886665_3	910314.HMPREF9220_0134	2.177e-56	210.0	COG1663@1|root,COG1663@2|Bacteria,1TWGA@1239|Firmicutes,4H97G@909932|Negativicutes	909932|Negativicutes	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Glycos_transf_N,LpxK
XH1_k127_7886665_6	880073.Calab_2504	1.792e-14	78.0	COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria	2|Bacteria	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
XH1_k127_7899134_1	1480694.DC28_09710	1.405e-06	54.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
XH1_k127_7899134_0	706587.Desti_4120	7.847e-117	383.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MQAR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
XH1_k127_7903951_0	1519464.HY22_13100	3.086e-64	235.0	COG2114@1|root,COG2114@2|Bacteria,1FFF9@1090|Chlorobi	1090|Chlorobi	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
XH1_k127_7910021_0	889378.Spiaf_1157	5.37e-223	700.0	COG0488@1|root,COG0488@2|Bacteria,2J5P1@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
XH1_k127_7910021_2	273063.STK_23050	8.578e-64	232.0	COG0123@1|root,arCOG00324@2157|Archaea,2XQB3@28889|Crenarchaeota	28889|Crenarchaeota	BQ	PFAM Histone deacetylase	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
XH1_k127_7910021_1	667014.Thein_0253	9.187e-156	498.0	COG0473@1|root,COG0473@2|Bacteria,2GGUW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
XH1_k127_7915645_1	1156937.MFUM_1020065	1.027e-35	140.0	COG1043@1|root,COG1043@2|Bacteria,46SQN@74201|Verrucomicrobia,37G0M@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
XH1_k127_7915645_0	880073.Calab_3665	1.91e-72	256.0	COG1044@1|root,COG1044@2|Bacteria,2NNSF@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
XH1_k127_7929480_1	1250232.JQNJ01000001_gene3736	2.234e-53	190.0	COG1052@1|root,COG1052@2|Bacteria,4NIHV@976|Bacteroidetes,1HX33@117743|Flavobacteriia	976|Bacteroidetes	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
XH1_k127_7929480_0	309799.DICTH_1465	1.257e-115	381.0	COG0540@1|root,COG0540@2|Bacteria	2|Bacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15490	OTCace,OTCace_N
XH1_k127_7929480_2	338966.Ppro_2528	7.981e-31	124.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,43TM6@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
XH1_k127_7930932_3	1288494.EBAPG3_9050	9.729e-09	57.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,372MM@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
XH1_k127_7930932_1	56780.SYN_02788	1.718e-93	315.0	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MQYP@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH1_k127_7930932_0	431943.CKL_3332	8.33e-105	358.0	COG1543@1|root,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,248UF@186801|Clostridia,36G2G@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
XH1_k127_7930932_2	273068.TTE1578	4.736e-77	262.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
XH1_k127_7939022_1	1254432.SCE1572_36880	1.241e-73	255.0	COG0573@1|root,COG0581@1|root,COG0573@2|Bacteria,COG0581@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2Z0WI@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
XH1_k127_7939022_0	880072.Desac_2633	6.435e-103	342.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MQY5@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
XH1_k127_7939022_2	632335.Calkr_1144	7.544e-67	237.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,42EPR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM extracellular solute-binding protein family 1	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
XH1_k127_7952702_1	909663.KI867150_gene1278	8.566e-279	863.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJN6@28221|Deltaproteobacteria,2MQ5G@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
XH1_k127_7952702_2	439235.Dalk_3266	1.179e-167	552.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
XH1_k127_7952702_0	1125863.JAFN01000001_gene224	0.0	1011.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,43BMM@68525|delta/epsilon subdivisions,2WJJV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
XH1_k127_7952702_4	1125863.JAFN01000001_gene225	6.812e-59	214.0	COG1414@1|root,COG1414@2|Bacteria,1QDXF@1224|Proteobacteria,42ZWN@68525|delta/epsilon subdivisions,2WV9I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
XH1_k127_7952702_3	555088.DealDRAFT_0047	1.025e-96	331.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,42JSF@68298|Syntrophomonadaceae	186801|Clostridia	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	noxE	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
XH1_k127_7957570_0	1265505.ATUG01000001_gene3881	8.007e-126	429.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
XH1_k127_7957570_1	639282.DEFDS_1218	3.511e-40	154.0	COG0543@1|root,COG0543@2|Bacteria,2GF6C@200930|Deferribacteres	200930|Deferribacteres	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
XH1_k127_7963182_2	243232.MJ_0631	1.921e-10	69.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23QZ1@183939|Methanococci	183939|Methanococci	O	PFAM peptidase M52 hydrogen uptake protein	-	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
XH1_k127_7963182_0	338966.Ppro_2788	4.063e-80	276.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,43UVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	hdrF	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
XH1_k127_7963182_1	338966.Ppro_2789	2.002e-42	160.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,43VYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
XH1_k127_7965046_1	1163617.SCD_n01879	6.631e-21	104.0	COG5544@1|root,COG5544@2|Bacteria,1R35W@1224|Proteobacteria,2VR90@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted periplasmic lipoprotein (DUF2279)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2279
XH1_k127_7965046_0	1304885.AUEY01000004_gene962	6.885e-184	582.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2MIB1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	VWA containing CoxE family protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
XH1_k127_7966039_0	439235.Dalk_4821	1.396e-48	182.0	COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,43AEY@68525|delta/epsilon subdivisions,2X5UP@28221|Deltaproteobacteria,2MPG3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
XH1_k127_7966039_1	439235.Dalk_4822	1.358e-35	147.0	COG0392@1|root,COG0392@2|Bacteria,1NKHR@1224|Proteobacteria	1224|Proteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
XH1_k127_7974244_0	395493.BegalDRAFT_1112	4.011e-15	85.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T4BF@1236|Gammaproteobacteria	1224|Proteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	chiS	-	2.7.13.3	ko:K07711,ko:K19694	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HTH_18,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg,Y_Y_Y
XH1_k127_7985762_0	161156.JQKW01000008_gene602	1.021e-134	441.0	COG0014@1|root,COG0014@2|Bacteria,2GH1U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
XH1_k127_7985762_1	1031288.AXAA01000011_gene610	5.704e-39	153.0	COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,36I7Z@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
XH1_k127_8002969_1	547042.BACCOPRO_00197	5.126e-17	87.0	COG2227@1|root,COG2227@2|Bacteria,4NGVF@976|Bacteroidetes,2FPTZ@200643|Bacteroidia,4AN7E@815|Bacteroidaceae	976|Bacteroidetes	H	Methyltransferase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
XH1_k127_8002969_0	56780.SYN_01565	6.62e-77	271.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MQCW@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
XH1_k127_8002969_2	1316932.MHH_c03940	4.673e-16	89.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1Y82H@135625|Pasteurellales	135625|Pasteurellales	LU	protein involved in DNA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
XH1_k127_8008842_0	1304874.JAFY01000007_gene1724	5.708e-61	213.0	COG0104@1|root,COG0104@2|Bacteria,3TA4C@508458|Synergistetes	508458|Synergistetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
XH1_k127_8008842_1	1485545.JQLW01000010_gene1600	1.332e-07	55.0	2972U@1|root,2ZUB3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_8015223_1	298386.PBPRB1539	2.978e-16	81.0	COG1414@1|root,COG3276@1|root,COG1414@2|Bacteria,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,1RQJI@1236|Gammaproteobacteria,1XWBW@135623|Vibrionales	135623|Vibrionales	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_3
XH1_k127_8015223_0	1304284.L21TH_1095	1.03e-42	171.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,36FJB@31979|Clostridiaceae	186801|Clostridia	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
XH1_k127_8020723_0	880072.Desac_0377	8.327e-127	415.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2MQ5C@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
XH1_k127_8020723_1	1158345.JNLL01000001_gene1825	8.217e-53	197.0	COG2890@1|root,COG2890@2|Bacteria,2G42H@200783|Aquificae	200783|Aquificae	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
XH1_k127_8020723_3	439235.Dalk_5265	1.232e-06	60.0	28NIF@1|root,2ZBJV@2|Bacteria,1RB8P@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_8020723_2	555079.Toce_1511	1.432e-34	135.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,42G26@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
XH1_k127_8034398_0	1307761.L21SP2_0391	3.618e-71	263.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_806391_0	203119.Cthe_3035	9.689e-68	233.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,3WGQB@541000|Ruminococcaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
XH1_k127_806391_1	472759.Nhal_0454	1.893e-19	101.0	COG0524@1|root,COG2208@1|root,COG3829@1|root,COG0524@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,1QW3T@1224|Proteobacteria,1T2RS@1236|Gammaproteobacteria,1WXRG@135613|Chromatiales	135613|Chromatiales	KT	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,Response_reg,SpoIIE
XH1_k127_8067114_0	335543.Sfum_3083	2.459e-144	464.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MQ6K@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
XH1_k127_8067114_1	756499.Desde_3399	7.928e-94	322.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,2616Y@186807|Peptococcaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
XH1_k127_8075687_1	1399115.U719_14250	6.433e-19	93.0	COG4878@1|root,COG4878@2|Bacteria,1TT2Y@1239|Firmicutes,4HGN3@91061|Bacilli	91061|Bacilli	S	Uncharacterised protein conserved in bacteria (DUF2194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2194
XH1_k127_8075687_2	1121378.KB899715_gene889	5.469e-07	62.0	2DR4U@1|root,33A62@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CreD
XH1_k127_8075687_0	1392489.JPOL01000002_gene2240	4.644e-59	212.0	COG2342@1|root,COG2342@2|Bacteria,4NH17@976|Bacteroidetes,1I03F@117743|Flavobacteriia	976|Bacteroidetes	G	Glycoside-hydrolase family GH114	-	-	6.1.1.16	ko:K01884	ko00970,map00970	M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Glyco_hydro_114
XH1_k127_8084134_0	574087.Acear_2101	6.021e-93	324.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,3WA96@53433|Halanaerobiales	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
XH1_k127_8087559_0	401526.TcarDRAFT_2120	1.731e-100	336.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,4H2W2@909932|Negativicutes	909932|Negativicutes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
XH1_k127_8087559_1	573413.Spirs_1581	1.269e-80	282.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
XH1_k127_8089685_0	1415774.U728_3621	4.22e-149	487.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,36DE5@31979|Clostridiaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
XH1_k127_8089685_1	484770.UFO1_4469	1.515e-69	258.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4H1X4@909932|Negativicutes	909932|Negativicutes	D	FtsK SpoIIIE family protein	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
XH1_k127_8107864_1	1170562.Cal6303_4254	1.766e-92	310.0	COG0058@1|root,COG0058@2|Bacteria,1G1HB@1117|Cyanobacteria,1HM60@1161|Nostocales	1117|Cyanobacteria	G	PFAM glycosyl transferase, family 35	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
XH1_k127_8107864_0	1279009.ADICEAN_01587	9.691e-135	441.0	COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes,47N91@768503|Cytophagia	976|Bacteroidetes	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
XH1_k127_8123294_0	933262.AXAM01000048_gene2601	1.271e-120	417.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
XH1_k127_8148471_0	439235.Dalk_5142	1.517e-127	424.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MI4U@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
XH1_k127_8148471_1	37659.JNLN01000001_gene2478	5.983e-05	53.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,36DJT@31979|Clostridiaceae	186801|Clostridia	M	stage V sporulation protein D	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
XH1_k127_8172921_1	1278307.KB907016_gene3437	5.455e-84	285.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RMVZ@1236|Gammaproteobacteria,2QJAP@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	Cysteine-rich domain	ykgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K18928	-	-	-	-	ko00000	-	-	iEC042_1314.EC042_0340,iEcSMS35_1347.EcSMS35_0338	CCG
XH1_k127_8172921_0	880073.Calab_2494	3.668e-100	334.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
XH1_k127_8172921_3	573413.Spirs_3022	4.596e-11	69.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
XH1_k127_8172921_4	314231.FP2506_02475	2.068e-05	48.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,2PJMW@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	MA20_24420	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
XH1_k127_8172921_2	246194.CHY_1775	1.747e-28	119.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,42FHT@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
XH1_k127_8179714_1	927658.AJUM01000015_gene3194	1.516e-39	147.0	COG4123@1|root,COG4123@2|Bacteria,4PNTF@976|Bacteroidetes,2G0Y0@200643|Bacteroidia	976|Bacteroidetes	S	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
XH1_k127_8179714_0	926562.Oweho_0457	1.391e-123	420.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,4NEVN@976|Bacteroidetes,1HYQY@117743|Flavobacteriia,2PBN1@246874|Cryomorphaceae	976|Bacteroidetes	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,TPR_12,TPR_8
XH1_k127_818258_1	768670.Calni_0942	7.176e-05	54.0	COG1366@1|root,COG1413@1|root,COG1366@2|Bacteria,COG1413@2|Bacteria,2GEMC@200930|Deferribacteres	200930|Deferribacteres	CT	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,STAS
XH1_k127_818258_0	439235.Dalk_4463	8.465e-11	70.0	COG1309@1|root,COG1309@2|Bacteria,1MYFS@1224|Proteobacteria,42T8F@68525|delta/epsilon subdivisions,2WPCH@28221|Deltaproteobacteria,2MK58@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
XH1_k127_8183726_2	748727.CLJU_c26420	1.375e-26	117.0	COG2836@1|root,COG2836@2|Bacteria,1VXKF@1239|Firmicutes,24ERT@186801|Clostridia,36HRG@31979|Clostridiaceae	186801|Clostridia	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
XH1_k127_8183726_1	391009.Tmel_0803	5.901e-31	139.0	COG1449@1|root,COG4945@1|root,COG1449@2|Bacteria,COG4945@2|Bacteria,2GC51@200918|Thermotogae	200918|Thermotogae	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Glucodextran_C,Glyco_hydro_57
XH1_k127_8183726_0	1047013.AQSP01000048_gene2211	9.118e-56	201.0	COG0348@1|root,COG0348@2|Bacteria,2NQW5@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_10,Fer4_5,Fer4_9
XH1_k127_8190060_3	909663.KI867150_gene137	1.896e-41	158.0	COG0589@1|root,COG0589@2|Bacteria,1PFB7@1224|Proteobacteria,43A9K@68525|delta/epsilon subdivisions,2X2D8@28221|Deltaproteobacteria,2MS6X@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
XH1_k127_8190060_5	1047013.AQSP01000120_gene948	4.164e-28	119.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Flavodoxin_5
XH1_k127_8190060_7	192952.MM_2839	5.388e-20	104.0	COG0714@1|root,arCOG00436@2157|Archaea,2XWN2@28890|Euryarchaeota,2N9JN@224756|Methanomicrobia	224756|Methanomicrobia	S	AAA domain (dynein-related subfamily)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
XH1_k127_8190060_4	1243664.CAVL020000008_gene4372	1.469e-31	137.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1VCNJ@1239|Firmicutes,4HVBX@91061|Bacilli,1ZS41@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MHYT,PAS_9
XH1_k127_8190060_6	573413.Spirs_2354	4.905e-23	107.0	2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
XH1_k127_8190060_1	468059.AUHA01000003_gene1635	9.777e-78	273.0	COG1198@1|root,COG1198@2|Bacteria,4P0NS@976|Bacteroidetes	976|Bacteroidetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_8190060_2	526224.Bmur_0876	7.73e-44	166.0	COG1335@1|root,COG1335@2|Bacteria,2J8QS@203691|Spirochaetes	203691|Spirochaetes	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
XH1_k127_8190060_0	903818.KI912268_gene2071	5.291e-153	494.0	COG0436@1|root,COG0436@2|Bacteria,3Y2TF@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
XH1_k127_8190060_8	526222.Desal_0871	8.05e-18	91.0	COG2227@1|root,COG2227@2|Bacteria,1RKH0@1224|Proteobacteria,42Q2I@68525|delta/epsilon subdivisions,2WJME@28221|Deltaproteobacteria,2M9G0@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
XH1_k127_8199197_1	351627.Csac_1295	5.507e-21	97.0	COG1406@1|root,COG1406@2|Bacteria,1V6JI@1239|Firmicutes,25DXQ@186801|Clostridia,42H88@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM CheC domain protein	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
XH1_k127_8199197_3	1122173.AXVL01000043_gene2040	3.044e-08	65.0	COG0760@1|root,COG0760@2|Bacteria,3796T@32066|Fusobacteria	32066|Fusobacteria	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
XH1_k127_8199197_2	671143.DAMO_1551	6.48e-16	78.0	COG2835@1|root,COG2835@2|Bacteria,2NQ60@2323|unclassified Bacteria	2|Bacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
XH1_k127_8199197_0	1123376.AUIU01000003_gene1635	2.339e-169	544.0	COG0587@1|root,COG0587@2|Bacteria,3J0FE@40117|Nitrospirae	40117|Nitrospirae	L	DNA-directed DNA polymerase	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
XH1_k127_8208399_3	572544.Ilyop_0652	3.447e-44	167.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
XH1_k127_8208399_2	933262.AXAM01000049_gene3260	2.137e-82	279.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42RB7@68525|delta/epsilon subdivisions,2WN5V@28221|Deltaproteobacteria,2MJQK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
XH1_k127_8208399_1	1121468.AUBR01000006_gene373	2.282e-128	421.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,42EUU@68295|Thermoanaerobacterales	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
XH1_k127_8208399_0	404380.Gbem_0496	3.995e-136	444.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
XH1_k127_821875_0	1121405.dsmv_0753	9.873e-169	537.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42PEN@68525|delta/epsilon subdivisions,2WJ9F@28221|Deltaproteobacteria,2MIQU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
XH1_k127_821875_2	1304888.ATWF01000002_gene194	4.084e-138	444.0	COG0559@1|root,COG0559@2|Bacteria,2GF7N@200930|Deferribacteres	200930|Deferribacteres	P	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
XH1_k127_821875_1	1232437.KL662032_gene2500	2.919e-160	515.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M11@68525|delta/epsilon subdivisions,2WK66@28221|Deltaproteobacteria,2MI46@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
XH1_k127_821875_7	1056495.Calag_0061	2.516e-23	104.0	COG0537@1|root,arCOG00419@2157|Archaea	2157|Archaea	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	-	-	2.5.1.3,2.7.7.53	ko:K02503,ko:K19710,ko:K21220	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00126,R01618,R03223,R10712	RC00002,RC00224,RC02753,RC02795,RC03255,RC03397	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT,ThiP_synth
XH1_k127_821875_3	1121405.dsmv_0756	1.162e-110	363.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJ48@28221|Deltaproteobacteria,2MITM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
XH1_k127_821875_5	439235.Dalk_4384	2.79e-106	349.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2MIWW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
XH1_k127_821875_6	1123057.P872_13075	6.052e-50	185.0	COG4122@1|root,COG4122@2|Bacteria,4PBU1@976|Bacteroidetes,47WBZ@768503|Cytophagia	976|Bacteroidetes	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
XH1_k127_821875_4	1379698.RBG1_1C00001G1494	1.5e-110	366.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
XH1_k127_822668_0	945713.IALB_0806	3.724e-54	196.0	COG0231@1|root,COG0231@2|Bacteria	2|Bacteria	J	translation elongation factor activity	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
XH1_k127_822668_1	1041930.Mtc_1880	4.107e-34	137.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,2N9TV@224756|Methanomicrobia	224756|Methanomicrobia	F	adenylyl cyclase CyaB	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
XH1_k127_822668_2	759914.BP951000_0015	5.606e-16	87.0	COG5401@1|root,COG5401@2|Bacteria,2J7JQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
XH1_k127_8234917_1	517417.Cpar_1205	5.802e-114	372.0	COG1512@1|root,COG1512@2|Bacteria,1FENY@1090|Chlorobi	1090|Chlorobi	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
XH1_k127_8234917_0	1232437.KL662075_gene1670	6.532e-130	418.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MIFH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
XH1_k127_8253187_1	604354.TSIB_1870	8.274e-50	183.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,24415@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
XH1_k127_8253187_0	565034.BHWA1_02581	2.496e-203	644.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
XH1_k127_8253187_2	1125863.JAFN01000001_gene3327	6.024e-21	96.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
XH1_k127_8258044_1	1028806.GGE_1318	6.526e-68	239.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1Y6ZR@135625|Pasteurellales	135625|Pasteurellales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD2	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
XH1_k127_8258044_0	706587.Desti_2024	2.529e-100	332.0	COG0784@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
XH1_k127_8263498_2	56780.SYN_02871	7.718e-37	139.0	COG0599@1|root,COG0599@2|Bacteria,1Q5KF@1224|Proteobacteria,42SAS@68525|delta/epsilon subdivisions,2WP9N@28221|Deltaproteobacteria,2MRQK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
XH1_k127_8263498_1	56780.SYN_00480	1.233e-178	566.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Acyl-CoA dehydrogenase	-	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
XH1_k127_8263498_3	1121405.dsmv_2550	2.786e-20	91.0	COG4770@1|root,COG4770@2|Bacteria,1NCKN@1224|Proteobacteria,42W8Y@68525|delta/epsilon subdivisions,2WRW7@28221|Deltaproteobacteria,2MM43@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
XH1_k127_8263498_0	1121405.dsmv_1458	6.517e-217	679.0	COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	gcdA	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Carboxyl_trans
XH1_k127_8270095_2	335543.Sfum_2659	9.582e-28	115.0	COG3287@1|root,COG3287@2|Bacteria,1Q5S5@1224|Proteobacteria,431QC@68525|delta/epsilon subdivisions,2WWE6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
XH1_k127_8270095_1	1158318.ATXC01000001_gene62	2.408e-47	180.0	COG2199@1|root,COG3287@1|root,COG3287@2|Bacteria,COG3706@2|Bacteria,2G4WY@200783|Aquificae	200783|Aquificae	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_9
XH1_k127_8270095_0	5932.XP_004027221.1	2.037e-58	216.0	COG4642@1|root,COG5253@1|root,KOG0229@2759|Eukaryota,KOG0231@2759|Eukaryota	2759|Eukaryota	DZ	MORN repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	MORN
XH1_k127_8276125_1	1499967.BAYZ01000171_gene5617	4.923e-94	321.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
XH1_k127_8276125_0	96561.Dole_2534	1.99e-127	436.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
XH1_k127_8276125_3	760568.Desku_3149	1.173e-40	155.0	COG1329@1|root,COG1329@2|Bacteria,1V40K@1239|Firmicutes,24HHP@186801|Clostridia,261IA@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
XH1_k127_8276125_2	592027.CLG_B1931	7.877e-80	277.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,248F4@186801|Clostridia,36DKW@31979|Clostridiaceae	186801|Clostridia	S	PFAM PilT protein domain protein	yacL	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
XH1_k127_8279012_0	439235.Dalk_3469	2.443e-78	284.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,42PK9@68525|delta/epsilon subdivisions,2WM9F@28221|Deltaproteobacteria,2MJ6C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
XH1_k127_8288666_0	1449126.JQKL01000026_gene2441	2.892e-207	651.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,267WP@186813|unclassified Clostridiales	186801|Clostridia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
XH1_k127_8289434_0	404380.Gbem_2419	1.101e-120	413.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
XH1_k127_8299009_0	1047013.AQSP01000113_gene739	1.305e-234	734.0	COG4868@1|root,COG4868@2|Bacteria,2NQM9@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1846)	XK27_07020	-	-	-	-	-	-	-	-	-	-	-	DUF1846
XH1_k127_8299009_1	909663.KI867150_gene2237	2.291e-161	521.0	COG0034@1|root,COG0034@2|Bacteria,1R7JX@1224|Proteobacteria,42MAC@68525|delta/epsilon subdivisions,2WKFD@28221|Deltaproteobacteria,2MQ6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Glutamine amidotransferase domain	-	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
XH1_k127_8299009_2	56780.SYN_03221	1.392e-08	55.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
XH1_k127_831357_1	644282.Deba_1228	5.65e-34	137.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,42THA@68525|delta/epsilon subdivisions,2WNG6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
XH1_k127_831357_0	526224.Bmur_0089	4.539e-74	258.0	COG1352@1|root,COG1352@2|Bacteria,2J7GX@203691|Spirochaetes	203691|Spirochaetes	NT	CheR methyltransferase, SAM binding domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
XH1_k127_831357_2	644282.Deba_1228	2.24e-18	87.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,42THA@68525|delta/epsilon subdivisions,2WNG6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
XH1_k127_83209_1	744872.Spica_2521	7.592e-55	201.0	COG2199@1|root,COG3706@2|Bacteria,2J6RG@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
XH1_k127_83209_0	754027.HMPREF9554_00730	2.443e-60	221.0	COG2199@1|root,COG3706@2|Bacteria,2J5S2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
XH1_k127_8357087_0	648996.Theam_0502	2.163e-124	411.0	COG0008@1|root,COG0008@2|Bacteria,2G3SV@200783|Aquificae	200783|Aquificae	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
XH1_k127_8357087_1	880073.Calab_2186	1.554e-34	137.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
XH1_k127_8357087_2	1121405.dsmv_2512	4.885e-17	85.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,2MK6X@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
XH1_k127_8361173_0	759914.BP951000_1674	6.594e-200	630.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
XH1_k127_8375157_2	96561.Dole_1511	1.169e-36	151.0	COG1597@1|root,COG1597@2|Bacteria,1PV0P@1224|Proteobacteria,42XZR@68525|delta/epsilon subdivisions,2WTF1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM diacylglycerol kinase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
XH1_k127_8375157_0	236097.ADG881_2026	1.247e-52	189.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1XJIQ@135619|Oceanospirillales	135619|Oceanospirillales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
XH1_k127_8375157_1	391613.RTM1035_07288	7.028e-41	154.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,46NSU@74030|Roseovarius	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
XH1_k127_8376196_0	795359.TOPB45_0286	2.663e-93	314.0	COG0422@1|root,COG0422@2|Bacteria,2GGW7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
XH1_k127_8376196_1	909663.KI867150_gene850	1.669e-45	168.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
XH1_k127_8408648_1	1211813.CAPH01000003_gene1386	2.958e-17	89.0	2FK1S@1|root,34BPZ@2|Bacteria,4P558@976|Bacteroidetes,2FYSJ@200643|Bacteroidia	976|Bacteroidetes	S	Bacterial protein of unknown function (YtfJ_HI0045)	-	-	-	ko:K07109	-	-	-	-	ko00000	-	-	-	YtfJ_HI0045
XH1_k127_8408648_0	1444711.CCJF01000005_gene576	2.39e-123	409.0	COG1055@1|root,COG1055@2|Bacteria,2JFJT@204428|Chlamydiae	204428|Chlamydiae	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
XH1_k127_8433942_0	643562.Daes_1196	1.313e-74	260.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2M93E@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
XH1_k127_8433942_1	744872.Spica_2726	2.073e-58	213.0	COG1639@1|root,COG1639@2|Bacteria,2J74B@203691|Spirochaetes	203691|Spirochaetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
XH1_k127_8436095_0	1196029.ALIM01000023_gene247	1.054e-06	62.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,4HB9S@91061|Bacilli,1ZAY0@1386|Bacillus	91061|Bacilli	F	Belongs to the 5'-nucleotidase family	yfkN	-	3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45	ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	iYO844.BSU07840	5_nucleotid_C,Metallophos
XH1_k127_8439205_2	290317.Cpha266_0203	6.829e-48	175.0	COG3178@1|root,COG3178@2|Bacteria,1FEBN@1090|Chlorobi	1090|Chlorobi	S	PFAM aminoglycoside phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
XH1_k127_8439205_1	517417.Cpar_1930	2.006e-84	290.0	COG1208@1|root,COG1208@2|Bacteria,1FDKD@1090|Chlorobi	1090|Chlorobi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
XH1_k127_8439205_0	880073.Calab_1416	6.88e-102	348.0	COG0591@1|root,COG0591@2|Bacteria,2NR0M@2323|unclassified Bacteria	2|Bacteria	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
XH1_k127_8468214_1	543728.Vapar_3519	1.484e-58	210.0	COG0627@1|root,COG0627@2|Bacteria,1MY73@1224|Proteobacteria,2VS12@28216|Betaproteobacteria,4AF76@80864|Comamonadaceae	28216|Betaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
XH1_k127_8468214_0	439481.Aboo_0710	3.547e-79	272.0	COG0176@1|root,arCOG05061@2157|Archaea,2XTET@28890|Euryarchaeota,3F2MD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Transaldolase/Fructose-6-phosphate aldolase	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
XH1_k127_8510465_0	635013.TherJR_0360	8.551e-228	717.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,260QA@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
XH1_k127_8510465_1	1379858.N508_00942	3.99e-51	185.0	COG0440@1|root,COG0440@2|Bacteria,2GFE3@200930|Deferribacteres	200930|Deferribacteres	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ALS_ss_C
XH1_k127_8510465_2	1201288.M900_1427	1.817e-05	50.0	COG3714@1|root,COG3714@2|Bacteria,1PN0I@1224|Proteobacteria	1224|Proteobacteria	S	membrane	yhhN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	YhhN
XH1_k127_8515039_1	1115515.EV102420_08_00490	1.55e-13	79.0	COG1309@1|root,COG1309@2|Bacteria,1R5AI@1224|Proteobacteria,1S6BI@1236|Gammaproteobacteria,3XPXB@561|Escherichia	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	ytfA	-	-	ko:K19736	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_7,TetR_N
XH1_k127_8515039_2	1047013.AQSP01000118_gene1234	4.297e-12	79.0	COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
XH1_k127_8515039_0	264462.Bd3058	1.035e-62	224.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2MTNI@213481|Bdellovibrionales,2WJ8D@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
XH1_k127_8533115_0	102232.GLO73106DRAFT_00002880	2.847e-15	89.0	2AQ5P@1|root,31FB4@2|Bacteria,1G7CB@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_8568663_0	574087.Acear_0257	1.518e-29	123.0	COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia,3WAV1@53433|Halanaerobiales	186801|Clostridia	N	TIGRFAM flagellar biosynthetic protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
XH1_k127_8573514_0	756272.Plabr_0785	9.894e-112	389.0	COG2373@1|root,COG2373@2|Bacteria,2IWRT@203682|Planctomycetes	203682|Planctomycetes	S	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
XH1_k127_8578704_1	1167632.AJTR01000012_gene979	8.538e-10	62.0	COG0483@1|root,COG0483@2|Bacteria,1TR4E@1239|Firmicutes,4HB92@91061|Bacilli,4GXXW@90964|Staphylococcaceae	91061|Bacilli	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
XH1_k127_8578704_2	402881.Plav_2678	0.0001338	54.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2UE45@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tpr repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5,TPR_16,TPR_19
XH1_k127_8578704_0	760011.Spico_0283	1.834e-95	324.0	COG0482@1|root,COG0482@2|Bacteria,2J6BI@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
XH1_k127_8578704_3	1042156.CXIVA_19610	0.0003133	43.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
XH1_k127_8595232_1	945713.IALB_0524	3.004e-31	139.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
XH1_k127_8595232_0	234267.Acid_5892	2.766e-82	283.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
XH1_k127_86305_1	314230.DSM3645_16045	1.278e-36	147.0	COG0793@1|root,COG0793@2|Bacteria,2IXI9@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
XH1_k127_86305_0	224324.aq_1899	2.32e-100	336.0	COG0463@1|root,COG0463@2|Bacteria,2G3VF@200783|Aquificae	200783|Aquificae	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
XH1_k127_8654971_2	1410618.JNKI01000002_gene900	4.511e-11	64.0	COG2199@1|root,COG3287@1|root,COG3287@2|Bacteria,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,4H234@909932|Negativicutes	909932|Negativicutes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF
XH1_k127_8654971_0	868131.MSWAN_0192	2.063e-114	374.0	COG0708@1|root,arCOG02207@2157|Archaea,2XVJ5@28890|Euryarchaeota,23PEV@183925|Methanobacteria	183925|Methanobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
XH1_k127_8654971_1	944479.JQLX01000011_gene742	2.36e-27	119.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
XH1_k127_8654971_3	313606.M23134_03033	1.428e-06	55.0	COG2227@1|root,COG2227@2|Bacteria,4NGVF@976|Bacteroidetes,47K52@768503|Cytophagia	976|Bacteroidetes	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
XH1_k127_8657015_0	1307761.L21SP2_2703	8.521e-261	825.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
XH1_k127_8680528_1	269484.Ecaj_0658	9.822e-89	302.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,47G6H@766|Rickettsiales	766|Rickettsiales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
XH1_k127_8680528_0	267377.MMP0178	1.055e-92	312.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,23QEB@183939|Methanococci	183939|Methanococci	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
XH1_k127_8681867_0	880073.Calab_1855	4.286e-222	709.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
XH1_k127_8681867_1	936053.I1C6Y3	2.389e-24	105.0	COG0251@1|root,KOG2317@2759|Eukaryota,3A5RT@33154|Opisthokonta,3P5AT@4751|Fungi,1GX4F@112252|Fungi incertae sedis	4751|Fungi	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
XH1_k127_869100_0	572546.Arcpr_0660	1.715e-285	891.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
XH1_k127_869100_1	1192034.CAP_1628	2.37e-74	260.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2YVFG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
XH1_k127_8696476_1	1121405.dsmv_2369	3.062e-31	124.0	2EBS7@1|root,335S2@2|Bacteria,1NBWR@1224|Proteobacteria,42WCA@68525|delta/epsilon subdivisions,2WRUH@28221|Deltaproteobacteria,2MKKJ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH1_k127_8696476_0	56780.SYN_01071	1.567e-143	465.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PYA@68525|delta/epsilon subdivisions,2WKM5@28221|Deltaproteobacteria,2MQB0@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
XH1_k127_8696476_2	1250005.PHEL85_1137	4.368e-19	90.0	COG4191@1|root,COG4191@2|Bacteria,4NSNP@976|Bacteroidetes,1I323@117743|Flavobacteriia,3VWNX@52959|Polaribacter	976|Bacteroidetes	T	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
XH1_k127_8696476_3	1122990.BAJH01000012_gene1635	5.712e-19	86.0	COG1149@1|root,COG1149@2|Bacteria,4PKZM@976|Bacteroidetes	976|Bacteroidetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
XH1_k127_872701_2	1111134.HMPREF1253_0100	2.747e-16	84.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,22FZ4@1570339|Peptoniphilaceae	186801|Clostridia	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
XH1_k127_872701_0	1480694.DC28_01175	9.714e-39	153.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
XH1_k127_872701_1	1289135.A966_04871	2.134e-35	142.0	COG0193@1|root,COG0193@2|Bacteria	2|Bacteria	J	aminoacyl-tRNA hydrolase activity	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
XH1_k127_8750317_2	316067.Geob_3440	4.642e-104	346.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43TZF@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
XH1_k127_8750317_0	744872.Spica_0175	3.993e-131	436.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,2J59H@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
XH1_k127_8750317_1	877455.Metbo_1754	8.401e-110	361.0	arCOG01778@1|root,arCOG01778@2157|Archaea,2XU6W@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
XH1_k127_8792175_0	526224.Bmur_0733	3.064e-23	115.0	COG1345@1|root,COG1345@2|Bacteria,2J6CW@203691|Spirochaetes	203691|Spirochaetes	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
XH1_k127_8794912_0	439235.Dalk_1854	8.312e-211	677.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MIG4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
XH1_k127_8822797_2	658088.HMPREF0987_01428	3.81e-14	76.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,27J92@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
XH1_k127_8822797_0	935845.JADQ01000029_gene1220	1.22e-105	371.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,26SN1@186822|Paenibacillaceae	91061|Bacilli	M	Carboxypeptidase	pbpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.4.1.129,3.4.16.4	ko:K21464	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
XH1_k127_8822797_1	759914.BP951000_2274	1.314e-21	100.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M23
XH1_k127_8822830_1	1121396.KB892935_gene3851	2.313e-170	544.0	COG1032@1|root,COG1307@1|root,COG1461@1|root,COG1032@2|Bacteria,COG1307@2|Bacteria,COG1461@2|Bacteria,1MWR0@1224|Proteobacteria,439ZF@68525|delta/epsilon subdivisions,2WU71@28221|Deltaproteobacteria,2MN5E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Dak2,DegV,Radical_SAM
XH1_k127_8822830_0	1121403.AUCV01000014_gene4642	3.887e-173	551.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42PFM@68525|delta/epsilon subdivisions,2WJVK@28221|Deltaproteobacteria,2MJ4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
XH1_k127_8822830_2	1121403.AUCV01000014_gene4643	6.805e-07	52.0	COG0236@1|root,COG0236@2|Bacteria,1PBR6@1224|Proteobacteria,43361@68525|delta/epsilon subdivisions,2WY5N@28221|Deltaproteobacteria,2MP4R@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
XH1_k127_8835841_0	555079.Toce_0772	2.134e-281	882.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,42ER6@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
XH1_k127_8835841_1	1291050.JAGE01000001_gene663	1.59e-91	304.0	COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,2480X@186801|Clostridia,3WGYH@541000|Ruminococcaceae	186801|Clostridia	J	S-adenosylmethionine-dependent methyltransferase	rlmL_1	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
XH1_k127_8838114_1	1259795.ARJK01000003_gene674	6.832e-49	181.0	COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,42G34@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
XH1_k127_8838114_2	694431.DESACE_07720	5.172e-29	124.0	COG1280@1|root,COG1280@2|Bacteria	2|Bacteria	E	homoserine transmembrane transporter activity	-	-	-	ko:K06895	-	-	-	-	ko00000,ko02000	2.A.75.1	-	-	LysE
XH1_k127_8838114_0	639282.DEFDS_0110	2.008e-51	190.0	COG3494@1|root,COG3494@2|Bacteria,2GF7V@200930|Deferribacteres	200930|Deferribacteres	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
XH1_k127_8850356_0	1125863.JAFN01000001_gene502	1.464e-07	64.0	COG1657@1|root,COG1657@2|Bacteria,1QX5U@1224|Proteobacteria,42ZX1@68525|delta/epsilon subdivisions,2WVF4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
XH1_k127_8853279_0	1120953.AUBH01000005_gene2377	4.014e-76	286.0	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,464UY@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Adenylate cyclase	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Adenyl_cycl_N,Adenylate_cycl
XH1_k127_952632_0	1123517.JOMR01000001_gene246	2.94e-47	192.0	COG2114@1|root,COG2114@2|Bacteria,1RDES@1224|Proteobacteria,1S0RQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	ladC	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
XH1_k127_952632_1	1448139.AI20_14120	3.453e-11	64.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1Y5C5@135624|Aeromonadales	135624|Aeromonadales	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
## 1357 queries scanned
## Total time (seconds): 13.612853765487671
## Rate: 99.69 q/s