## Sat Oct 19 00:43:53 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/XH3_bin.25.fa -m mmseqs --itype genome -o XH3_bin.25 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/XH3_bin.25 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
XH3_k127_1056211_0	593750.Metfor_2137	2.668e-309	964.0	COG0550@1|root,arCOG00416@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,2N96B@224756|Methanomicrobia	224756|Methanomicrobia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
XH3_k127_1056211_1	323259.Mhun_1010	3.327e-99	328.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
XH3_k127_1085140_2	456442.Mboo_2236	2.445e-53	195.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
XH3_k127_1085140_3	456442.Mboo_2237	1.128e-13	73.0	arCOG01354@1|root,arCOG01354@2157|Archaea,2Y224@28890|Euryarchaeota,2NA54@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1085140_0	521011.Mpal_2658	6.927e-244	762.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
XH3_k127_1085140_1	593750.Metfor_0461	2.228e-79	268.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,2N9KM@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
XH3_k127_1107630_2	456442.Mboo_1253	5.745e-31	126.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
XH3_k127_1107630_1	1151117.AJLF01000001_gene844	2.666e-63	228.0	COG1525@1|root,arCOG08231@1|root,arCOG03192@2157|Archaea,arCOG08231@2157|Archaea,2XTIT@28890|Euryarchaeota,2447M@183968|Thermococci	183968|Thermococci	L	Staphylococcal nuclease homologues	-	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	LTD,SNase
XH3_k127_1107630_0	593750.Metfor_1665	5.226e-194	612.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,2NAEH@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
XH3_k127_1107630_4	521011.Mpal_0020	1.129e-09	63.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	dmpI	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
XH3_k127_1107630_3	1449357.JQLK01000001_gene780	2.805e-11	70.0	COG0506@1|root,COG0506@2|Bacteria,1WJB7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Proline dehydrogenase	-	GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0046983,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
XH3_k127_112358_3	456442.Mboo_0073	1.992e-14	75.0	COG0785@1|root,arCOG02400@2157|Archaea,2Y0J2@28890|Euryarchaeota,2NBK2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM cytochrome c biogenesis protein, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
XH3_k127_112358_2	368407.Memar_0155	5.325e-26	111.0	COG1605@1|root,arCOG02098@2157|Archaea,2Y6AQ@28890|Euryarchaeota,2N9YR@224756|Methanomicrobia	224756|Methanomicrobia	E	chorismate mutase	aroQ	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
XH3_k127_112358_1	368407.Memar_0156	1.088e-68	241.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_112358_0	593750.Metfor_0934	3.428e-71	241.0	COG0310@1|root,arCOG02248@2157|Archaea,2XU13@28890|Euryarchaeota,2N96W@224756|Methanomicrobia	224756|Methanomicrobia	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
XH3_k127_1193773_1	323259.Mhun_2491	5.665e-69	237.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
XH3_k127_1193773_0	593750.Metfor_1538	2.188e-201	633.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N92K@224756|Methanomicrobia	224756|Methanomicrobia	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
XH3_k127_1193773_2	456442.Mboo_1462	1.721e-50	185.0	COG1813@1|root,arCOG01863@2157|Archaea,2XYZ0@28890|Euryarchaeota,2N9WA@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
XH3_k127_1265907_3	324925.Ppha_1607	4.026e-119	390.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	atmc2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
XH3_k127_1265907_7	1041930.Mtc_0340	4.955e-53	201.0	COG5542@1|root,arCOG10055@2157|Archaea	2157|Archaea	S	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
XH3_k127_1265907_10	351160.RCIX1527	1.663e-21	96.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota,2NA1I@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
XH3_k127_1265907_6	521011.Mpal_2221	6.014e-101	334.0	COG0842@1|root,arCOG01463@2157|Archaea,2XX4N@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
XH3_k127_1265907_2	521011.Mpal_2220	3.779e-136	440.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,2NAAZ@224756|Methanomicrobia	224756|Methanomicrobia	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
XH3_k127_1265907_9	351160.RCIX733	2.348e-24	108.0	COG5513@1|root,arCOG03544@2157|Archaea,2Y0YF@28890|Euryarchaeota	28890|Euryarchaeota	S	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
XH3_k127_1265907_0	247490.KSU1_D0184	3.654e-240	766.0	COG1067@1|root,COG1067@2|Bacteria,2J2AD@203682|Planctomycetes	203682|Planctomycetes	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
XH3_k127_1265907_5	456442.Mboo_2291	1.094e-103	344.0	arCOG01778@1|root,arCOG01778@2157|Archaea,2XU6W@28890|Euryarchaeota,2N9ES@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
XH3_k127_1265907_4	572547.Amico_0219	3.955e-105	349.0	COG0428@1|root,COG0428@2|Bacteria,3T9UW@508458|Synergistetes	508458|Synergistetes	P	PFAM zinc iron permease	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
XH3_k127_1265907_8	456442.Mboo_1431	5.893e-33	138.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
XH3_k127_1265907_11	456442.Mboo_1174	8.395e-17	81.0	arCOG09481@1|root,arCOG09481@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1265907_1	679926.Mpet_1731	5.021e-220	693.0	COG0069@1|root,COG1773@1|root,arCOG00619@2157|Archaea,arCOG04391@2157|Archaea,2Y7H6@28890|Euryarchaeota,2N95Y@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase,Rubredoxin
XH3_k127_1271926_0	395493.BegalDRAFT_1699	2.287e-298	925.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,461Y7@72273|Thiotrichales	72273|Thiotrichales	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
XH3_k127_1271926_2	593750.Metfor_2050	1.654e-47	175.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota,2NB49@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM TspO MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
XH3_k127_1271926_1	368407.Memar_0594	1.199e-80	275.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,2NAVM@224756|Methanomicrobia	224756|Methanomicrobia	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
XH3_k127_1275601_3	456442.Mboo_1783	2.082e-111	362.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
XH3_k127_1275601_0	593750.Metfor_1318	1.072e-279	869.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,2N90X@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM oxaloacetate decarboxylase alpha subunit	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1586	Biotin_lipoyl,HMGL-like,PYC_OADA
XH3_k127_1275601_7	368407.Memar_1645	2.578e-55	204.0	COG1122@1|root,arCOG00188@2157|Archaea	2157|Archaea	P	PFAM ABC transporter related	phnG	-	2.7.8.37	ko:K02068,ko:K03529,ko:K06166,ko:K16786,ko:K16787	ko00440,ko02010,map00440,map02010	M00211,M00582	R10185	RC00005,RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko03036	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,PhnG,SMC_N,SMC_hinge
XH3_k127_1275601_6	456442.Mboo_1787	1.576e-59	213.0	COG3839@1|root,arCOG00211@2157|Archaea	2157|Archaea	G	PFAM ABC transporter	-	-	-	ko:K16786	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
XH3_k127_1275601_8	521011.Mpal_1014	7.339e-52	188.0	COG1268@1|root,arCOG02986@2157|Archaea,2XWSG@28890|Euryarchaeota,2N9UN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM BioY protein	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
XH3_k127_1275601_2	456442.Mboo_1789	9.385e-157	499.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,2N982@224756|Methanomicrobia	224756|Methanomicrobia	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
XH3_k127_1275601_5	593750.Metfor_1324	1.171e-59	210.0	COG4048@1|root,arCOG04902@2157|Archaea,2Y8FE@28890|Euryarchaeota,2N9Y6@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111
XH3_k127_1275601_4	521011.Mpal_1017	2.094e-68	237.0	arCOG04998@1|root,arCOG04998@2157|Archaea,2XZR1@28890|Euryarchaeota,2N9VB@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1275601_1	593750.Metfor_1326	1.09e-163	520.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,2N90W@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
XH3_k127_1284425_0	593750.Metfor_1614	1.613e-101	342.0	COG1624@1|root,arCOG02348@1|root,arCOG02385@1|root,arCOG02348@2157|Archaea,arCOG02385@2157|Archaea,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota	28890|Euryarchaeota	T	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N,PK_C
XH3_k127_1284425_1	857293.CAAU_1317	1.307e-89	301.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36DXA@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
XH3_k127_1288218_6	456442.Mboo_0241	9.335e-20	91.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,2NA60@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
XH3_k127_1288218_3	593750.Metfor_2871	8.315e-34	132.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,2NA0E@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
XH3_k127_1288218_2	368407.Memar_2244	6.281e-51	184.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
XH3_k127_1288218_5	368407.Memar_2243	8.408e-27	112.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
XH3_k127_1288218_0	593750.Metfor_2868	8.345e-96	317.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,2N9GJ@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
XH3_k127_1288218_4	521011.Mpal_0604	3.995e-27	117.0	COG1412@1|root,arCOG04312@2157|Archaea,2XX55@28890|Euryarchaeota,2N9V2@224756|Methanomicrobia	224756|Methanomicrobia	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
XH3_k127_1288218_1	456442.Mboo_0247	1.762e-61	213.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,2N93K@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
XH3_k127_1302491_2	593750.Metfor_0590	6.686e-28	118.0	COG5635@1|root,arCOG02967@2157|Archaea	2157|Archaea	T	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
XH3_k127_1302491_1	593750.Metfor_0591	1.284e-81	282.0	COG2314@1|root,COG5635@1|root,arCOG02967@2157|Archaea,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
XH3_k127_1302491_3	368407.Memar_0998	6.194e-23	101.0	arCOG03365@1|root,arCOG03365@2157|Archaea,2Y1W5@28890|Euryarchaeota,2NA3V@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1302491_0	593750.Metfor_2114	1.692e-261	814.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
XH3_k127_1308359_6	368407.Memar_1460	6.636e-08	55.0	COG1992@1|root,arCOG00021@2157|Archaea,2Y84Z@28890|Euryarchaeota,2NBNT@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine-phosphate synthase	-	-	2.5.1.3	ko:K21220	ko00730,ko01100,map00730,map01100	-	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	ThiP_synth
XH3_k127_1308359_3	521011.Mpal_0793	2.487e-109	363.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
XH3_k127_1308359_2	456442.Mboo_1392	1.075e-111	365.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2N931@224756|Methanomicrobia	224756|Methanomicrobia	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
XH3_k127_1308359_4	456442.Mboo_1391	7.472e-79	268.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,2N955@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,TRAM
XH3_k127_1308359_1	593750.Metfor_1817	4.345e-129	417.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,2N9FQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
XH3_k127_1308359_5	456442.Mboo_1389	5.96e-60	211.0	arCOG05301@1|root,arCOG05301@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1308359_0	368407.Memar_1467	5.135e-137	447.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,2NB5W@224756|Methanomicrobia	224756|Methanomicrobia	E	peptidase dimerisation domain	argE	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
XH3_k127_1310504_1	1499967.BAYZ01000147_gene697	1.593e-17	83.0	COG1839@1|root,COG1839@2|Bacteria,2NPAQ@2323|unclassified Bacteria	2|Bacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
XH3_k127_1310504_2	410358.Mlab_0285	9.679e-09	57.0	arCOG04838@1|root,arCOG04838@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1310504_0	1121090.KB894690_gene628	1.913e-23	110.0	COG0506@1|root,COG0506@2|Bacteria,1TQV3@1239|Firmicutes,4HAC1@91061|Bacilli,1ZB5G@1386|Bacillus	91061|Bacilli	E	Proline dehydrogenase	ycgM	GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
XH3_k127_1338038_3	456442.Mboo_1073	2.184e-34	133.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
XH3_k127_1338038_0	593750.Metfor_2307	5.583e-163	530.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,2N94D@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
XH3_k127_1338038_2	593750.Metfor_2306	1.901e-38	153.0	COG1255@1|root,arCOG04385@2157|Archaea,2XYWU@28890|Euryarchaeota,2NBE6@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0146 family	-	-	-	ko:K09713	-	-	-	-	ko00000	-	-	-	UPF0146
XH3_k127_1338038_1	593750.Metfor_2305	8.129e-50	183.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota,2NBBC@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase zinc-dependent	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
XH3_k127_1374453_0	269799.Gmet_1212	5.097e-100	338.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,42S0X@68525|delta/epsilon subdivisions,2WNBW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	sensor histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
XH3_k127_1374453_1	387631.Asulf_01351	6.506e-41	158.0	COG0637@1|root,arCOG02293@2157|Archaea,2Y7WB@28890|Euryarchaeota,246TW@183980|Archaeoglobi	183980|Archaeoglobi	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
XH3_k127_1379920_2	323259.Mhun_2257	1.663e-70	239.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
XH3_k127_1379920_1	456442.Mboo_0529	8.625e-109	360.0	COG1085@1|root,arCOG00420@2157|Archaea,2XWY6@28890|Euryarchaeota	28890|Euryarchaeota	C	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1379920_0	456442.Mboo_0530	1.136e-152	488.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,2N9GS@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
XH3_k127_1379920_3	368407.Memar_0563	6.716e-61	212.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,2NB55@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM sigma-70 region 4 domain protein	-	-	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
XH3_k127_1379920_4	593750.Metfor_2655	1.034e-38	145.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,2N98A@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
XH3_k127_1388862_3	368407.Memar_1516	1.252e-34	138.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
XH3_k127_1388862_4	386456.JQKN01000013_gene3021	1.919e-08	59.0	COG1342@1|root,arCOG02238@2157|Archaea,2Y128@28890|Euryarchaeota,23PN7@183925|Methanobacteria	183925|Methanobacteria	K	Protein of unknown function  DUF134	-	-	-	ko:K06933	-	-	-	-	ko00000	-	-	-	DUF134
XH3_k127_1388862_0	593750.Metfor_0356	2.487e-287	891.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,2N96H@224756|Methanomicrobia	224756|Methanomicrobia	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
XH3_k127_1388862_1	593750.Metfor_0355	9.876e-52	186.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2N9XB@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
XH3_k127_1388862_2	368407.Memar_0465	3.178e-44	167.0	COG3612@1|root,arCOG04418@2157|Archaea,2XXT8@28890|Euryarchaeota,2NA4A@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
XH3_k127_140164_1	593750.Metfor_1772	4.109e-128	413.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,2N920@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Semialdehyde dehydrogenase NAD - binding	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
XH3_k127_140164_4	323259.Mhun_1494	2.095e-21	94.0	COG1145@1|root,arCOG04117@2157|Archaea,2Y7JN@28890|Euryarchaeota,2NBK8@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
XH3_k127_140164_2	456442.Mboo_1397	3.328e-114	374.0	COG0289@1|root,arCOG04393@2157|Archaea,2XTJU@28890|Euryarchaeota,2N9BV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
XH3_k127_140164_0	593750.Metfor_1775	4.317e-145	464.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
XH3_k127_140164_5	410358.Mlab_1226	5.934e-20	90.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,2NA41@224756|Methanomicrobia	224756|Methanomicrobia	J	structural constituent of ribosome	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
XH3_k127_140164_3	368407.Memar_1460	7.204e-53	189.0	COG1992@1|root,arCOG00021@2157|Archaea,2Y84Z@28890|Euryarchaeota,2NBNT@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine-phosphate synthase	-	-	2.5.1.3	ko:K21220	ko00730,ko01100,map00730,map01100	-	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	ThiP_synth
XH3_k127_14180_0	456442.Mboo_2243	2.711e-170	541.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,2N92E@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
XH3_k127_14180_1	368407.Memar_1940	3.731e-22	103.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
XH3_k127_14180_2	593750.Metfor_0457	4.933e-06	49.0	arCOG03479@1|root,arCOG03479@2157|Archaea,2Y0TG@28890|Euryarchaeota,2NB1D@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1435703_3	593750.Metfor_1087	7.445e-22	97.0	COG1534@1|root,arCOG01346@2157|Archaea,2Y6W9@28890|Euryarchaeota,2NA5I@224756|Methanomicrobia	224756|Methanomicrobia	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
XH3_k127_1435703_2	368407.Memar_1975	1.722e-30	123.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota	28890|Euryarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
XH3_k127_1435703_1	368407.Memar_1976	4.484e-90	300.0	COG0299@1|root,arCOG02825@2157|Archaea,2Y838@28890|Euryarchaeota,2N9JE@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM formyl transferase domain protein	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2317	Formyl_trans_N
XH3_k127_1435703_0	593750.Metfor_1084	4.331e-155	497.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,2N962@224756|Methanomicrobia	224756|Methanomicrobia	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
XH3_k127_1436041_3	456442.Mboo_1327	2.559e-76	263.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,2N9PQ@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidylprolyl isomerase FKBP-type	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
XH3_k127_1436041_5	521011.Mpal_1572	2.904e-50	184.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,2N9TV@224756|Methanomicrobia	224756|Methanomicrobia	F	adenylyl cyclase CyaB	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
XH3_k127_1436041_2	593750.Metfor_1531	9.649e-90	299.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXXF@28890|Euryarchaeota,2N9PM@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
XH3_k127_1436041_1	368407.Memar_0931	2.175e-144	466.0	COG1032@1|root,arCOG01356@2157|Archaea,2XUA3@28890|Euryarchaeota,2N9AZ@224756|Methanomicrobia	224756|Methanomicrobia	C	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
XH3_k127_1436041_7	521011.Mpal_1312	6.532e-20	94.0	arCOG07676@1|root,arCOG07676@2157|Archaea	2157|Archaea	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1436041_4	456442.Mboo_1457	5.075e-54	193.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
XH3_k127_1436041_0	456442.Mboo_1458	6.011e-181	576.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N947@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM 26S proteasome subunit P45 family	pan-1	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
XH3_k127_1436041_6	593750.Metfor_1536	3.263e-34	138.0	arCOG04642@1|root,arCOG04642@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1449196_2	456442.Mboo_1327	3.022e-17	81.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,2N9PQ@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidylprolyl isomerase FKBP-type	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
XH3_k127_1449196_1	368407.Memar_1260	2.076e-27	123.0	arCOG02605@1|root,arCOG02605@2157|Archaea	2157|Archaea	S	Roadblock LC7	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
XH3_k127_1449196_3	593750.Metfor_1068	9.83e-07	56.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota,2NB1F@224756|Methanomicrobia	224756|Methanomicrobia	S	Roadblock LC7	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
XH3_k127_1449196_4	642492.Clole_1340	4.961e-05	52.0	COG2972@1|root,COG2972@2|Bacteria,1TSF9@1239|Firmicutes,2499Y@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
XH3_k127_1449196_0	521011.Mpal_1701	5.178e-98	325.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,2N963@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
XH3_k127_1533357_8	679926.Mpet_0195	1.332e-07	55.0	COG2104@1|root,arCOG00535@2157|Archaea	2157|Archaea	H	Sulfur transfer protein involved in thiamine biosynthesis	samp2	GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564	2.8.1.15	ko:K03154,ko:K21947	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiS
XH3_k127_1533357_1	593750.Metfor_0290	3.584e-243	761.0	COG0459@1|root,arCOG01258@2157|Archaea,2Y86B@28890|Euryarchaeota,2NBNW@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the TCP-1 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
XH3_k127_1533357_5	456442.Mboo_2394	2.52e-80	274.0	COG0856@1|root,arCOG00028@2157|Archaea,2XU2R@28890|Euryarchaeota,2N9NM@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	pyrE-2	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
XH3_k127_1533357_6	368407.Memar_0273	8.413e-47	175.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,2NA00@224756|Methanomicrobia	224756|Methanomicrobia	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
XH3_k127_1533357_4	368407.Memar_0274	4.978e-102	342.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2N9B3@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
XH3_k127_1533357_3	593750.Metfor_0293	1.029e-103	344.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,2N92A@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
XH3_k127_1533357_0	456442.Mboo_2391	1.847e-317	982.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
XH3_k127_1533357_2	593750.Metfor_0295	1.752e-187	595.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
XH3_k127_1533357_7	521011.Mpal_2692	1.244e-32	132.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
XH3_k127_1584172_8	593750.Metfor_1975	3.117e-16	81.0	arCOG05293@1|root,arCOG05293@2157|Archaea	2157|Archaea	G	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1584172_3	323259.Mhun_2995	3.491e-62	217.0	COG3467@1|root,arCOG00520@2157|Archaea,2XXWD@28890|Euryarchaeota,2NAW4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
XH3_k127_1584172_4	593750.Metfor_2573	1.597e-55	199.0	arCOG09584@1|root,arCOG09584@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_1584172_5	456442.Mboo_1628	1.794e-49	181.0	arCOG05293@1|root,arCOG05293@2157|Archaea	2157|Archaea	G	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
XH3_k127_1584172_1	456442.Mboo_1105	1.33e-225	705.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
XH3_k127_1584172_6	368407.Memar_1819	4.711e-29	117.0	COG1476@1|root,arCOG01864@2157|Archaea,2XZS8@28890|Euryarchaeota,2NB5P@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM helix-turn-helix domain protein	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
XH3_k127_1584172_0	521011.Mpal_2625	0.0	1304.0	COG0685@1|root,arCOG04487@2157|Archaea,2XU03@28890|Euryarchaeota,2NAHD@224756|Methanomicrobia	224756|Methanomicrobia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
XH3_k127_1584172_7	368407.Memar_1631	1.188e-18	88.0	COG1531@1|root,arCOG01302@2157|Archaea	2157|Archaea	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
XH3_k127_1601604_1	456442.Mboo_1868	2.138e-59	211.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,2N9RR@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM methyltransferase small	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
XH3_k127_1601604_0	593750.Metfor_1115	3.746e-69	237.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
XH3_k127_1602783_4	368407.Memar_0008	1.045e-53	192.0	COG1270@1|root,arCOG04274@2157|Archaea,2XT37@28890|Euryarchaeota,2N9JD@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
XH3_k127_1602783_1	456442.Mboo_0008	4.904e-150	478.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,2N9DB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
XH3_k127_1602783_3	593750.Metfor_0170	3.755e-65	228.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,2N9HT@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
XH3_k127_1602783_2	323259.Mhun_0342	2.166e-84	285.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAFK@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
XH3_k127_1602783_5	880526.KE386488_gene427	2.662e-05	48.0	COG0474@1|root,COG0474@2|Bacteria,4NERM@976|Bacteroidetes,2FMEC@200643|Bacteroidia,22U9J@171550|Rikenellaceae	976|Bacteroidetes	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
XH3_k127_1602783_0	593750.Metfor_0943	4.99e-264	828.0	COG0531@1|root,arCOG00009@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Trp_Tyr_perm,Usp
XH3_k127_1608190_0	456442.Mboo_0523	1.06e-220	690.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,2N9C6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,Molydop_binding,PYNP_C
XH3_k127_1608190_1	593750.Metfor_2664	3.966e-75	266.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,CarboxypepD_reg,DDOST_48kD,PEGA
XH3_k127_1633338_3	456442.Mboo_1444	2.431e-76	258.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
XH3_k127_1633338_6	590998.Celf_0800	1.218e-47	175.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,4F21C@85016|Cellulomonadaceae	201174|Actinobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
XH3_k127_1633338_5	401526.TcarDRAFT_0620	2.27e-53	197.0	COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,4H2SP@909932|Negativicutes	909932|Negativicutes	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
XH3_k127_1633338_4	644966.Tmar_1127	6.799e-58	212.0	COG3285@1|root,COG3285@2|Bacteria,1TSAC@1239|Firmicutes,24BRE@186801|Clostridia,3WDHS@538999|Clostridiales incertae sedis	186801|Clostridia	L	DNA polymerase LigD, polymerase domain	ligD1	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
XH3_k127_1633338_0	521011.Mpal_0942	4.944e-190	602.0	COG1232@1|root,arCOG01522@2157|Archaea,2XY37@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
XH3_k127_1633338_1	521011.Mpal_0941	2.062e-131	427.0	COG0438@1|root,arCOG01407@2157|Archaea,2XUJ8@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0438 Glycosyltransferase	gth2	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
XH3_k127_1633338_2	521011.Mpal_1536	4.836e-101	333.0	COG0463@1|root,arCOG01386@2157|Archaea,2Y7Y7@28890|Euryarchaeota,2NBN5@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
XH3_k127_1633338_7	593750.Metfor_1708	5.21e-32	129.0	COG2050@1|root,arCOG00777@2157|Archaea	2157|Archaea	Q	protein possibly involved in aromatic compounds catabolism	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
XH3_k127_1664467_2	521011.Mpal_0540	3.492e-53	190.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,2N9JT@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
XH3_k127_1664467_4	521011.Mpal_0541	1.726e-18	86.0	COG2157@1|root,arCOG04175@2157|Archaea	2157|Archaea	J	PFAM Ribosomal LX protein	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
XH3_k127_1664467_3	593750.Metfor_1107	1.207e-47	175.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y1IQ@28890|Euryarchaeota,2NA28@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
XH3_k127_1664467_1	368407.Memar_1965	2.917e-147	472.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,2N9A4@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
XH3_k127_1664467_0	521011.Mpal_0544	4.44e-229	715.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,2N99J@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
XH3_k127_1768609_0	456442.Mboo_1084	0.0	1071.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,2N9EN@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
XH3_k127_1770097_4	521011.Mpal_2711	6.59e-68	233.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,2N98P@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine synthetase, type I	glnA-2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
XH3_k127_1770097_1	521011.Mpal_2710	3.53e-174	551.0	COG0067@1|root,arCOG00095@2157|Archaea,2XUF6@28890|Euryarchaeota,2N91X@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM glutamine amidotransferase, class-II	gltB1	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0665	GATase_2,GATase_6
XH3_k127_1770097_0	1094980.Mpsy_1373	3.294e-273	847.0	COG0069@1|root,arCOG00619@2157|Archaea,2Y7H6@28890|Euryarchaeota,2N95Y@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the glutamate synthase family	gltB2	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0664	Fer4,Fer4_10,Fer4_9,Glu_syn_central,Glu_synthase
XH3_k127_1770097_3	269797.Mbar_A0663	1.202e-102	339.0	COG0070@1|root,arCOG00096@2157|Archaea,2XW01@28890|Euryarchaeota,2N91Z@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM glutamate synthase alpha subunit domain protein	gltB3	-	-	-	-	-	-	-	-	-	-	-	GXGXG
XH3_k127_1770097_2	456442.Mboo_1693	2.079e-134	436.0	COG1035@1|root,arCOG02650@2157|Archaea,2XVXF@28890|Euryarchaeota,2N93J@224756|Methanomicrobia	224756|Methanomicrobia	C	Coenzyme F420 hydrogenase dehydrogenase, beta subunit	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_4,Fer4_6,FrhB_FdhB_C,FrhB_FdhB_N
XH3_k127_1770097_5	323259.Mhun_0597	1.291e-14	80.0	COG3291@1|root,arCOG02559@1|root,arCOG06792@1|root,arCOG02508@2157|Archaea,arCOG02559@2157|Archaea,arCOG06792@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
XH3_k127_1804295_1	593750.Metfor_0946	5.153e-24	104.0	COG2610@1|root,arCOG04923@2157|Archaea,2XTVG@28890|Euryarchaeota,2N9VJ@224756|Methanomicrobia	224756|Methanomicrobia	G	permease	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
XH3_k127_1804295_0	593750.Metfor_0631	4.281e-89	303.0	COG0655@1|root,arCOG02574@2157|Archaea	2157|Archaea	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
XH3_k127_1807648_2	593750.Metfor_2634	7.985e-46	166.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2N9JA@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM ribosomal protein L30P	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
XH3_k127_1807648_1	679926.Mpet_2210	6.078e-56	198.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2N9U7@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
XH3_k127_1807648_0	456442.Mboo_0555	7.496e-256	794.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,2N9AJ@224756|Methanomicrobia	224756|Methanomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
XH3_k127_1807648_3	593750.Metfor_2631	1.897e-07	53.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota	28890|Euryarchaeota	F	Belongs to the archaeal adenylate kinase family	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
XH3_k127_1812080_0	521011.Mpal_1196	9.028e-146	477.0	COG1226@1|root,arCOG01960@2157|Archaea,2XTQV@28890|Euryarchaeota,2N9KX@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM TrkA-N domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
XH3_k127_1812080_1	456442.Mboo_2324	2.303e-21	96.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,2N9N9@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
XH3_k127_1822461_1	456442.Mboo_0037	6.289e-37	149.0	COG0681@1|root,arCOG01739@2157|Archaea,2XU45@28890|Euryarchaeota,2N9SB@224756|Methanomicrobia	224756|Methanomicrobia	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
XH3_k127_1822461_0	593750.Metfor_0140	2.367e-207	653.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
XH3_k127_1822461_2	323259.Mhun_2414	1.38e-16	82.0	COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota	28890|Euryarchaeota	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
XH3_k127_1830710_5	368407.Memar_0063	7.448e-07	53.0	COG1361@1|root,arCOG04400@2157|Archaea,2XZN3@28890|Euryarchaeota,2N9X5@224756|Methanomicrobia	224756|Methanomicrobia	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
XH3_k127_1830710_3	456442.Mboo_1297	3.417e-40	159.0	COG2881@1|root,arCOG02054@2157|Archaea,2XTJC@28890|Euryarchaeota,2NA62@224756|Methanomicrobia	224756|Methanomicrobia	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
XH3_k127_1830710_1	323259.Mhun_2925	1.969e-98	330.0	COG0598@1|root,arCOG02265@2157|Archaea	2157|Archaea	P	Mediates influx of magnesium ions	corA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
XH3_k127_1830710_0	323259.Mhun_2478	7.256e-170	540.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9D7@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
XH3_k127_1830710_2	593750.Metfor_0113	1.779e-68	234.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,2N9NP@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
XH3_k127_1830710_4	593750.Metfor_0114	2.354e-22	96.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,2N9J0@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM riboflavin synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
XH3_k127_1889367_1	456442.Mboo_2308	7.397e-106	346.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,2N9SQ@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
XH3_k127_1889367_3	593750.Metfor_0349	3.942e-23	101.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68X@28890|Euryarchaeota,2NA5V@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
XH3_k127_1889367_2	593750.Metfor_0348	2.375e-89	299.0	COG1387@1|root,arCOG00304@2157|Archaea,2XVZY@28890|Euryarchaeota,2N90M@224756|Methanomicrobia	224756|Methanomicrobia	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
XH3_k127_1889367_4	593750.Metfor_0347	6.028e-22	96.0	COG3277@1|root,arCOG02466@2157|Archaea	2157|Archaea	J	RNA-binding protein involved in rRNA processing	gar1	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
XH3_k127_1889367_0	456442.Mboo_2311	8.499e-203	635.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
XH3_k127_1893880_1	593750.Metfor_2498	1.573e-24	107.0	COG1254@1|root,arCOG01674@2157|Archaea	2157|Archaea	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
XH3_k127_1893880_0	593750.Metfor_2499	1.373e-82	284.0	COG1518@1|root,arCOG01452@2157|Archaea	2157|Archaea	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas1
XH3_k127_1934521_3	593750.Metfor_1838	9.625e-12	64.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,2N937@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
XH3_k127_1934521_0	593750.Metfor_1838	2.634e-145	465.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,2N937@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
XH3_k127_1934521_1	694440.JOMF01000005_gene178	4.769e-103	343.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,2N97F@224756|Methanomicrobia	224756|Methanomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1465	Porphobil_deam,Porphobil_deamC
XH3_k127_1934521_2	368407.Memar_0984	1.432e-95	318.0	COG0007@1|root,arCOG00644@2157|Archaea,2XTE1@28890|Euryarchaeota,2N96Z@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
XH3_k127_1959159_1	368407.Memar_0559	2.128e-93	313.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
XH3_k127_1959159_0	521011.Mpal_0152	0.0	1513.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
XH3_k127_1959159_2	456442.Mboo_2270	3.224e-27	113.0	COG4021@1|root,arCOG03218@2157|Archaea,2XWU9@28890|Euryarchaeota,2N9I7@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNAHis guanylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thg1,Thg1C
XH3_k127_2019799_0	593750.Metfor_0946	1.148e-64	229.0	COG2610@1|root,arCOG04923@2157|Archaea,2XTVG@28890|Euryarchaeota,2N9VJ@224756|Methanomicrobia	224756|Methanomicrobia	G	permease	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
XH3_k127_2019799_1	1187848.AJYQ01000142_gene2020	1.579e-43	172.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,1S1PQ@1236|Gammaproteobacteria,1XV2D@135623|Vibrionales	135623|Vibrionales	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
XH3_k127_2061766_3	456442.Mboo_1730	4.407e-31	133.0	arCOG05201@1|root,arCOG05201@2157|Archaea,2Y5MT@28890|Euryarchaeota,2NBBE@224756|Methanomicrobia	224756|Methanomicrobia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2061766_1	456442.Mboo_1731	9.321e-77	261.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,2N9N1@224756|Methanomicrobia	224756|Methanomicrobia	F	cytidyltransferase-related domain	nadR	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
XH3_k127_2061766_0	456442.Mboo_1732	8.822e-104	342.0	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,2N9MD@224756|Methanomicrobia	224756|Methanomicrobia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
XH3_k127_2061766_2	593750.Metfor_1291	3.206e-33	130.0	arCOG04909@1|root,arCOG04909@2157|Archaea,2Y18R@28890|Euryarchaeota,2NA2P@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2103965_0	521011.Mpal_0221	3.138e-124	412.0	COG1361@1|root,arCOG02079@2157|Archaea,2XTCZ@28890|Euryarchaeota,2NBGV@224756|Methanomicrobia	28890|Euryarchaeota	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,NPCBM_assoc
XH3_k127_2103965_1	593750.Metfor_2583	8.377e-17	83.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia	224756|Methanomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
XH3_k127_213613_2	368407.Memar_0407	7.523e-19	87.0	arCOG09439@1|root,arCOG09439@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_213613_1	593750.Metfor_0400	3.036e-132	439.0	COG1234@1|root,COG1650@1|root,arCOG00501@2157|Archaea,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,2N9S6@224756|Methanomicrobia	224756|Methanomicrobia	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
XH3_k127_213613_0	456442.Mboo_2265	1.826e-139	447.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,2N926@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin,tRNA_deacylase
XH3_k127_2147695_3	679926.Mpet_0996	7.062e-05	45.0	COG2457@1|root,arCOG04458@2157|Archaea,2XZFN@28890|Euryarchaeota,2N9V4@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
XH3_k127_2147695_0	456442.Mboo_1413	1.215e-171	542.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,2N97M@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
XH3_k127_2147695_1	456442.Mboo_1412	7.72e-43	160.0	COG0375@1|root,arCOG04426@2157|Archaea,2Y0W9@28890|Euryarchaeota,2NB6Y@224756|Methanomicrobia	224756|Methanomicrobia	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
XH3_k127_2147695_2	593750.Metfor_1712	4.919e-11	64.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota,2NB98@224756|Methanomicrobia	224756|Methanomicrobia	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
XH3_k127_216301_6	368407.Memar_0248	3.628e-16	83.0	arCOG04907@1|root,arCOG04907@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_216301_5	593750.Metfor_2185	2.188e-44	164.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y238@28890|Euryarchaeota,2NBF2@224756|Methanomicrobia	224756|Methanomicrobia	S	Fe-S-cluster oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
XH3_k127_216301_3	521011.Mpal_1685	5.651e-59	209.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota,2NB42@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
XH3_k127_216301_1	351160.RRC245	4.317e-93	314.0	COG0667@1|root,arCOG06306@2157|Archaea,2XSXS@28890|Euryarchaeota,2NAJ5@224756|Methanomicrobia	224756|Methanomicrobia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
XH3_k127_216301_2	192952.MM_2426	3.745e-82	280.0	COG0412@1|root,arCOG01659@2157|Archaea,2XZUN@28890|Euryarchaeota	28890|Euryarchaeota	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH,Peptidase_S9
XH3_k127_216301_4	679926.Mpet_2150	1.267e-47	186.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
XH3_k127_216301_0	387631.Asulf_01342	4.984e-94	317.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,246UA@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	-
XH3_k127_2173859_1	368407.Memar_2038	3.497e-104	348.0	COG0388@1|root,arCOG00062@2157|Archaea,2XVVK@28890|Euryarchaeota,2NBG5@224756|Methanomicrobia	224756|Methanomicrobia	S	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase,PAD_porph
XH3_k127_2173859_0	368407.Memar_2038	1.33e-107	357.0	COG0388@1|root,arCOG00062@2157|Archaea,2XVVK@28890|Euryarchaeota,2NBG5@224756|Methanomicrobia	224756|Methanomicrobia	S	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase,PAD_porph
XH3_k127_2173859_2	368407.Memar_0594	6.419e-15	78.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,2NAVM@224756|Methanomicrobia	224756|Methanomicrobia	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
XH3_k127_2298546_2	5888.CAK91022	1.093e-18	89.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
XH3_k127_2298546_1	1122176.KB903598_gene4760	2.729e-27	129.0	COG3210@1|root,COG3210@2|Bacteria,4NGEX@976|Bacteroidetes	976|Bacteroidetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2298546_0	909663.KI867149_gene3176	1.67e-37	147.0	COG1913@1|root,COG1913@2|Bacteria,1N38I@1224|Proteobacteria,42UMZ@68525|delta/epsilon subdivisions,2WRS9@28221|Deltaproteobacteria,2MS0H@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
XH3_k127_2298546_3	521011.Mpal_2478	7.42e-13	72.0	arCOG04907@1|root,arCOG04907@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_231101_0	292415.Tbd_0367	6.279e-89	302.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_231101_1	368407.Memar_0354	1.894e-30	125.0	COG0530@1|root,arCOG02881@2157|Archaea,2XVHN@28890|Euryarchaeota,2N9UD@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
XH3_k127_2326706_0	357808.RoseRS_3064	0.0	1133.0	COG0474@1|root,COG0474@2|Bacteria,2G85U@200795|Chloroflexi,376M7@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
XH3_k127_2326706_2	357808.RoseRS_3063	7.675e-62	219.0	COG0569@1|root,COG0569@2|Bacteria,2G71A@200795|Chloroflexi,3777S@32061|Chloroflexia	32061|Chloroflexia	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
XH3_k127_2326706_1	383372.Rcas_2661	9.352e-81	274.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi,377FQ@32061|Chloroflexia	32061|Chloroflexia	C	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
XH3_k127_2326706_3	593750.Metfor_2565	4.483e-20	98.0	arCOG07676@1|root,arCOG07676@2157|Archaea	2157|Archaea	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2326706_4	456442.Mboo_1869	2.025e-12	72.0	arCOG04003@1|root,arCOG04003@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405
XH3_k127_2349751_0	456442.Mboo_2102	1.013e-127	413.0	COG2524@1|root,arCOG00610@2157|Archaea,2XVPF@28890|Euryarchaeota,2N96A@224756|Methanomicrobia	224756|Methanomicrobia	K	signal transduction protein with CBS domains	-	-	-	ko:K07744	-	-	-	-	ko00000	-	-	-	CBS,HrcA_DNA-bdg
XH3_k127_2349751_1	456442.Mboo_2103	4.919e-125	407.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2N941@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
XH3_k127_2349751_2	593750.Metfor_0714	4.578e-95	319.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
XH3_k127_2349751_4	593750.Metfor_0713	3.521e-14	77.0	arCOG04995@1|root,arCOG04995@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2349751_3	456442.Mboo_2106	1.578e-82	277.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,2N9EE@224756|Methanomicrobia	224756|Methanomicrobia	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
XH3_k127_2352669_8	323259.Mhun_0879	2.063e-34	135.0	arCOG03197@1|root,arCOG03197@2157|Archaea,2XZKC@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2352669_2	368407.Memar_0282	1.405e-233	740.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
XH3_k127_2352669_9	521011.Mpal_2681	2.283e-21	95.0	COG0636@1|root,arCOG02455@2157|Archaea,2XZRP@28890|Euryarchaeota,2N9ZA@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM H transporting two-sector ATPase C subunit	atpK-1	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0390	ATP-synt_C
XH3_k127_2352669_6	593750.Metfor_0312	1.512e-59	213.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,2N9TB@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
XH3_k127_2352669_4	593750.Metfor_0313	2.193e-131	428.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
XH3_k127_2352669_10	547559.Nmag_1372	3.314e-21	96.0	COG1436@1|root,arCOG04102@2157|Archaea,2XXYI@28890|Euryarchaeota,23W7A@183963|Halobacteria	183963|Halobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
XH3_k127_2352669_0	593750.Metfor_0315	0.0	1036.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
XH3_k127_2352669_1	521011.Mpal_2676	2.128e-278	858.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2N97D@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
XH3_k127_2352669_5	456442.Mboo_2343	3.581e-98	323.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,2N9IG@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0384	ATP-synt_D
XH3_k127_2352669_3	593750.Metfor_0318	1.258e-182	579.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,2N98M@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
XH3_k127_2352669_11	593750.Metfor_0319	1.152e-11	70.0	arCOG07551@1|root,arCOG07551@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2352669_7	521011.Mpal_1778	4.102e-45	166.0	COG1001@1|root,arCOG00693@2157|Archaea,2XV8C@28890|Euryarchaeota,2NACW@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
XH3_k127_2441899_5	521011.Mpal_2582	1.146e-54	196.0	COG1235@1|root,arCOG00499@2157|Archaea,2XTWY@28890|Euryarchaeota,2N9GT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM beta-lactamase domain protein	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
XH3_k127_2441899_0	593750.Metfor_2706	4.223e-174	555.0	COG0464@1|root,arCOG04368@2157|Archaea,2XT63@28890|Euryarchaeota,2N9B2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
XH3_k127_2441899_3	593750.Metfor_2705	1.016e-114	378.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
XH3_k127_2441899_2	456442.Mboo_0488	9.482e-120	396.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
XH3_k127_2441899_10	456442.Mboo_0489	6.051e-16	79.0	arCOG09499@1|root,arCOG09499@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2441899_8	456442.Mboo_0490	2.052e-31	125.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,2N9YC@224756|Methanomicrobia	224756|Methanomicrobia	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2441899_4	593750.Metfor_2699	2.315e-114	377.0	arCOG01220@1|root,arCOG01220@2157|Archaea,2XYGI@28890|Euryarchaeota,2N9S5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
XH3_k127_2441899_1	368407.Memar_2444	9.205e-144	461.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,2N9QE@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the LDH MDH superfamily	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
XH3_k127_2441899_7	521011.Mpal_2591	1.43e-31	124.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,2NA09@224756|Methanomicrobia	224756|Methanomicrobia	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
XH3_k127_2441899_9	593750.Metfor_2695	2.597e-24	102.0	COG2888@1|root,arCOG01989@2157|Archaea	2157|Archaea	J	Zn-ribbon RNA-binding protein with a function in translation	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
XH3_k127_2441899_6	456442.Mboo_0494	4.088e-53	196.0	COG2054@1|root,arCOG00859@2157|Archaea,2XVEI@28890|Euryarchaeota,2N9QG@224756|Methanomicrobia	224756|Methanomicrobia	S	aspartate glutamate uridylate kinase	-	-	2.7.4.31	ko:K07144	ko00680,map00680	-	R11039	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
XH3_k127_2441899_11	368407.Memar_2448	6.372e-16	78.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
XH3_k127_2472898_1	368407.Memar_0511	2.595e-88	301.0	COG2073@1|root,arCOG00651@2157|Archaea,2XTVD@28890|Euryarchaeota,2N9TZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM cobalamin (vitamin B12) biosynthesis CbiG protein	-	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N
XH3_k127_2472898_0	368407.Memar_0510	4.783e-94	314.0	COG2875@1|root,arCOG00645@2157|Archaea,2XSZA@28890|Euryarchaeota,2N9G2@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0627	TP_methylase
XH3_k127_2472898_2	593750.Metfor_1478	4.281e-76	260.0	COG2243@1|root,arCOG00648@2157|Archaea,2XTS5@28890|Euryarchaeota,2N9NT@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
XH3_k127_2472898_3	323259.Mhun_3209	1.201e-46	174.0	COG2242@1|root,arCOG00977@2157|Archaea,2XVKZ@28890|Euryarchaeota,2N9SF@224756|Methanomicrobia	224756|Methanomicrobia	Q	Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7	cbiT	-	2.1.1.196	ko:K02191	ko00860,map00860	-	R05813,R07774	RC00003,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	Methyltransf_18,Methyltransf_25,Methyltransf_31
XH3_k127_2472898_4	368407.Memar_0984	9.311e-29	117.0	COG0007@1|root,arCOG00644@2157|Archaea,2XTE1@28890|Euryarchaeota,2N96Z@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
XH3_k127_2499100_0	456442.Mboo_1253	2.347e-198	632.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
XH3_k127_2499100_4	456442.Mboo_0433	6.462e-10	68.0	arCOG07300@1|root,arCOG07300@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2499100_1	456442.Mboo_1254	1.393e-36	148.0	arCOG07763@1|root,arCOG07763@2157|Archaea	2157|Archaea	L	DNA polymerase activity	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	-
XH3_k127_2499100_3	593750.Metfor_1124	9.229e-11	64.0	arCOG07650@1|root,arCOG07650@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2509338_0	521011.Mpal_1087	8.569e-200	641.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
XH3_k127_2509338_1	456442.Mboo_1658	2.641e-120	393.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,2N9AW@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15,2.7.1.213,2.7.1.73	ko:K00852,ko:K22026	ko00030,ko00230,ko00240,map00030,map00230,map00240	-	R00513,R01051,R01131,R01228,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2903	PfkB
XH3_k127_2509338_3	368407.Memar_0858	3.797e-53	189.0	COG1885@1|root,arCOG02119@2157|Archaea,2XX3M@28890|Euryarchaeota,2N9T5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0212 family	-	-	-	ko:K09731	-	-	-	-	ko00000	-	-	-	DUF555
XH3_k127_2509338_2	456442.Mboo_1660	2.233e-68	238.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota,2NAXX@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
XH3_k127_2509338_5	593750.Metfor_2411	2.148e-24	106.0	arCOG04481@1|root,arCOG04481@2157|Archaea,2Y0HE@28890|Euryarchaeota,2NA4C@224756|Methanomicrobia	224756|Methanomicrobia	S	Family of unknown function (DUF5350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5350
XH3_k127_2509338_4	593750.Metfor_2410	2.349e-27	113.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,2N9BR@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
XH3_k127_2516625_1	1499967.BAYZ01000050_gene2841	2.408e-57	205.0	COG0345@1|root,COG0345@2|Bacteria	2|Bacteria	E	pyrroline-5-carboxylate reductase activity	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
XH3_k127_2516625_3	323259.Mhun_0858	2.017e-20	96.0	COG4273@1|root,arCOG03334@2157|Archaea,2Y597@28890|Euryarchaeota,2NB9K@224756|Methanomicrobia	224756|Methanomicrobia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
XH3_k127_2516625_2	1094980.Mpsy_0222	1.8e-43	163.0	arCOG06907@1|root,arCOG06907@2157|Archaea,2Y4IM@28890|Euryarchaeota,2NB6M@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2516625_0	323259.Mhun_0868	1.013e-69	244.0	arCOG02402@1|root,arCOG02402@2157|Archaea,2Y3IJ@28890|Euryarchaeota,2NAR6@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
XH3_k127_25398_4	1041930.Mtc_1152	2.746e-60	216.0	arCOG04580@1|root,arCOG04580@2157|Archaea,2XUWY@28890|Euryarchaeota,2NA9J@224756|Methanomicrobia	224756|Methanomicrobia	Q	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
XH3_k127_25398_0	593750.Metfor_1142	2.165e-139	449.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,2N99Z@224756|Methanomicrobia	224756|Methanomicrobia	F	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
XH3_k127_25398_1	368407.Memar_1690	1.169e-68	237.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2N9RS@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
XH3_k127_25398_6	192952.MM_3330	3.601e-19	96.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
XH3_k127_25398_2	521011.Mpal_2538	3.523e-64	223.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2N9RM@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM cytidyltransferase-related domain	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
XH3_k127_25398_3	456442.Mboo_1838	5.254e-62	217.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2N9S0@224756|Methanomicrobia	224756|Methanomicrobia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
XH3_k127_25398_5	456442.Mboo_1839	2.057e-26	110.0	COG1148@1|root,arCOG02234@2157|Archaea,2Y7JF@28890|Euryarchaeota,2NBK7@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,Pyr_redox_2
XH3_k127_2539886_0	368407.Memar_1063	5.403e-119	397.0	COG0138@1|root,arCOG02824@2157|Archaea,2XT5P@28890|Euryarchaeota,2N92Z@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0571	AICARFT_IMPCHas,MGS
XH3_k127_2539886_1	521011.Mpal_1512	3.427e-69	241.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2NAI4@224756|Methanomicrobia	224756|Methanomicrobia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,PAPS_reduct
XH3_k127_2560136_0	593750.Metfor_1666	6.834e-186	591.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8	ko:K00130,ko:K00135	ko00250,ko00260,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00260,map00310,map00350,map00650,map00760,map01100,map01120	M00027,M00555	R00713,R00714,R02401,R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
XH3_k127_2560136_1	868131.MSWAN_1064	3.419e-11	66.0	COG2006@1|root,arCOG02446@2157|Archaea,2XV9B@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
XH3_k127_2576714_4	368407.Memar_0837	2.188e-70	241.0	COG0040@1|root,arCOG02208@2157|Archaea,2XTZ3@28890|Euryarchaeota,2N9AD@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
XH3_k127_2576714_1	456442.Mboo_1066	3.911e-93	312.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,2N949@224756|Methanomicrobia	224756|Methanomicrobia	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
XH3_k127_2576714_3	593750.Metfor_2311	4.169e-78	265.0	COG0131@1|root,arCOG04398@2157|Archaea,2XT2K@28890|Euryarchaeota,2N9NB@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1310	IGPD
XH3_k127_2576714_6	357808.RoseRS_3392	0.0005777	48.0	COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
XH3_k127_2576714_5	323259.Mhun_0919	2.464e-28	114.0	COG2036@1|root,arCOG02144@2157|Archaea	2157|Archaea	K	transcription factor (CBF NF-Y)	hstA	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
XH3_k127_2576714_2	456442.Mboo_1072	3.927e-79	271.0	COG4002@1|root,arCOG00854@2157|Archaea,2XXS9@28890|Euryarchaeota,2N9HQ@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogen marker protein 4	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2576714_0	593750.Metfor_2308	5.806e-137	440.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
XH3_k127_259166_0	521011.Mpal_1317	2.67e-89	315.0	COG1624@1|root,COG3291@1|root,arCOG02510@2157|Archaea,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota,2N9M8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
XH3_k127_259166_2	593750.Metfor_1178	2.282e-62	220.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
XH3_k127_259166_1	667014.Thein_0108	2.67e-74	258.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.144,2.1.1.197	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
XH3_k127_259166_3	1336243.JAEA01000005_gene1488	0.0005997	43.0	2EAFX@1|root,32G8D@2|Bacteria,1RJFV@1224|Proteobacteria,2U9DS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2676033_4	593750.Metfor_1173	4.506e-20	97.0	COG2881@1|root,arCOG03630@2157|Archaea,2XYDD@28890|Euryarchaeota,2NBAT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
XH3_k127_2676033_1	456442.Mboo_1940	1.377e-104	347.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,2N97C@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
XH3_k127_2676033_3	593750.Metfor_1628	2.645e-23	100.0	arCOG07469@1|root,arCOG07469@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2676033_2	456442.Mboo_1585	9.36e-35	134.0	arCOG02866@1|root,arCOG02866@2157|Archaea,2Y8JA@28890|Euryarchaeota,2NB6N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2676033_0	593750.Metfor_1626	1.271e-230	719.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,2N92F@224756|Methanomicrobia	224756|Methanomicrobia	L	acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DnaJ_CXXCXGXG,S1,tRNA_anti-codon
XH3_k127_2744398_8	368407.Memar_2012	2.044e-30	122.0	COG3377@1|root,arCOG04424@2157|Archaea,2Y6W5@28890|Euryarchaeota,2NA3P@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF1805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1805
XH3_k127_2744398_2	368407.Memar_0048	3.799e-168	535.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota,2N942@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH-1	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
XH3_k127_2744398_4	593750.Metfor_0134	1.439e-80	282.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVMU@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
XH3_k127_2744398_7	521011.Mpal_0414	1.635e-33	144.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,2NB15@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
XH3_k127_2744398_3	456442.Mboo_0043	5.207e-85	286.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2N9QR@224756|Methanomicrobia	224756|Methanomicrobia	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
XH3_k127_2744398_0	456442.Mboo_0044	4.456e-201	633.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,2N91J@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine biosynthesis protein ThiC	thiC-1	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
XH3_k127_2744398_6	368407.Memar_0055	2.117e-52	187.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
XH3_k127_2744398_1	456442.Mboo_0053	6.936e-185	585.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,2N9EM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
XH3_k127_2744398_5	593750.Metfor_0114	4.799e-80	270.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,2N9J0@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM riboflavin synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
XH3_k127_2774495_0	368407.Memar_0399	1.067e-240	754.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH3_k127_2774495_1	368407.Memar_0400	3.362e-157	504.0	COG0517@1|root,arCOG00607@2157|Archaea,2XTE5@28890|Euryarchaeota,2N998@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
XH3_k127_2774495_3	593750.Metfor_0391	1.471e-30	122.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,2N9Y7@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
XH3_k127_2774495_2	456442.Mboo_2270	5.196e-71	247.0	COG4021@1|root,arCOG03218@2157|Archaea,2XWU9@28890|Euryarchaeota,2N9I7@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNAHis guanylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thg1,Thg1C
XH3_k127_2780431_0	521011.Mpal_0032	3.842e-289	895.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
XH3_k127_2780431_2	456442.Mboo_0195	3.468e-125	410.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,2N98I@224756|Methanomicrobia	224756|Methanomicrobia	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
XH3_k127_2780431_1	368407.Memar_2348	2.468e-173	552.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,2N9EI@224756|Methanomicrobia	224756|Methanomicrobia	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
XH3_k127_2780431_3	593750.Metfor_0008	2.858e-30	121.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2N91B@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-2	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
XH3_k127_2798440_3	323259.Mhun_1736	9.697e-32	130.0	COG1808@1|root,arCOG02264@2157|Archaea,2XTS3@28890|Euryarchaeota,2N9UP@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
XH3_k127_2798440_0	368407.Memar_0889	3.071e-86	293.0	arCOG01637@1|root,arCOG01637@2157|Archaea,2Y1E8@28890|Euryarchaeota,2NA48@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
XH3_k127_2798440_1	444158.MmarC6_0863	2.994e-82	280.0	arCOG03165@1|root,arCOG03165@2157|Archaea,2XXAZ@28890|Euryarchaeota,23QZB@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_2798440_2	593750.Metfor_0693	1.142e-35	141.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,2N985@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
XH3_k127_2842627_1	593750.Metfor_2660	4.262e-98	333.0	COG0206@1|root,arCOG08027@1|root,arCOG02202@2157|Archaea,arCOG08027@2157|Archaea,2XTM7@28890|Euryarchaeota	28890|Euryarchaeota	D	Involved in cell shape control	cetZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
XH3_k127_2842627_0	593750.Metfor_2661	9.992e-143	458.0	COG1693@1|root,arCOG02710@2157|Archaea,2XVGZ@28890|Euryarchaeota,2N90G@224756|Methanomicrobia	224756|Methanomicrobia	K	Ribonuclease R winged-helix domain	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
XH3_k127_2842627_2	593750.Metfor_2662	1.031e-49	180.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y071@28890|Euryarchaeota,2N9T7@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM deoxycytidine triphosphate deaminase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
XH3_k127_2858936_0	521011.Mpal_2254	0.0	1438.0	COG1933@1|root,arCOG03146@1|root,arCOG03146@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,2N91E@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
XH3_k127_2858936_3	456442.Mboo_0125	2.271e-36	143.0	arCOG07476@1|root,arCOG07476@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
XH3_k127_2858936_1	693661.Arcve_1143	3.697e-79	272.0	COG0668@1|root,arCOG01568@2157|Archaea,2XUHN@28890|Euryarchaeota,245QV@183980|Archaeoglobi	183980|Archaeoglobi	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
XH3_k127_2858936_2	368407.Memar_1776	3.058e-58	210.0	COG2430@1|root,arCOG01766@2157|Archaea,2XY9F@28890|Euryarchaeota,2N9PD@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF432)	-	-	-	ko:K09149	-	-	-	-	ko00000	-	-	-	DUF432
XH3_k127_2868799_3	351160.RRC150	1.194e-16	80.0	COG1073@1|root,arCOG01654@2157|Archaea,2Y0NH@28890|Euryarchaeota,2NA0N@224756|Methanomicrobia	224756|Methanomicrobia	S	Acetyl xylan esterase (AXE1)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	AXE1,Hydrolase_4
XH3_k127_2868799_0	593750.Metfor_2142	1.32e-304	942.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
XH3_k127_2868799_1	323259.Mhun_1008	2.398e-92	306.0	COG0717@1|root,arCOG04048@2157|Archaea,2XTSH@28890|Euryarchaeota	28890|Euryarchaeota	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13,3.5.4.30	ko:K01494,ko:K09887	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325,R07307	RC00074,RC01825	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
XH3_k127_2868799_5	1165841.SULAR_08302	3.247e-09	61.0	2EKUK@1|root,33EI9@2|Bacteria,1NJYU@1224|Proteobacteria	1224|Proteobacteria	S	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
XH3_k127_2868799_2	536227.CcarbDRAFT_1616	1.985e-77	267.0	COG2768@1|root,COG2768@2|Bacteria,1UJH4@1239|Firmicutes,25F2U@186801|Clostridia,36UWR@31979|Clostridiaceae	186801|Clostridia	C	binding domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
XH3_k127_2868799_4	456442.Mboo_0798	2.993e-16	83.0	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
XH3_k127_2924398_1	714943.Mucpa_3589	3.722e-71	256.0	COG1835@1|root,COG1835@2|Bacteria,4NIVR@976|Bacteroidetes,1ITNG@117747|Sphingobacteriia	976|Bacteroidetes	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
XH3_k127_2924398_0	192952.MM_1517	2.835e-113	377.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2N94V@224756|Methanomicrobia	224756|Methanomicrobia	E	DegT/DnrJ/EryC1/StrS aminotransferase family	nifS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
XH3_k127_2944739_2	521011.Mpal_0399	3.753e-67	232.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2N9T4@224756|Methanomicrobia	224756|Methanomicrobia	S	ZPR1-related zinc finger protein	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
XH3_k127_2944739_5	456442.Mboo_0091	4.743e-53	189.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2N9X3@224756|Methanomicrobia	224756|Methanomicrobia	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
XH3_k127_2944739_3	368407.Memar_0231	2.961e-65	227.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,2N9WM@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
XH3_k127_2944739_7	593750.Metfor_0049	6.105e-38	145.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,2NA2C@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Like-Sm ribonucleoprotein, core	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
XH3_k127_2944739_8	521011.Mpal_0395	3.327e-25	105.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,2NA67@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
XH3_k127_2944739_0	521011.Mpal_0394	3.796e-227	711.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,2N978@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
XH3_k127_2944739_6	368407.Memar_0227	1.263e-39	152.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
XH3_k127_2944739_4	591158.SSMG_05581	3.054e-60	214.0	COG0163@1|root,COG0163@2|Bacteria,2GKID@201174|Actinobacteria	201174|Actinobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
XH3_k127_2944739_1	593750.Metfor_0280	8.205e-178	569.0	COG1201@1|root,arCOG00557@2157|Archaea,2XXKJ@28890|Euryarchaeota,2NBGH@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C
XH3_k127_2961648_0	335543.Sfum_2075	3.775e-230	722.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MQ5R@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
XH3_k127_2961648_1	443144.GM21_2612	1.037e-79	269.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,43TJ3@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM DAHP synthetase I KDSA	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
XH3_k127_2961823_5	456442.Mboo_2060	1.478e-50	187.0	COG1468@1|root,arCOG00793@2157|Archaea,2Y05J@28890|Euryarchaeota,2NA1Y@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
XH3_k127_2961823_1	694440.JOMF01000007_gene907	7.612e-114	376.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,2N92D@224756|Methanomicrobia	224756|Methanomicrobia	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
XH3_k127_2961823_3	593750.Metfor_0970	4.282e-75	256.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,2N9VK@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
XH3_k127_2961823_2	593750.Metfor_0971	2.444e-101	335.0	COG1707@1|root,arCOG00813@2157|Archaea,2XT8A@28890|Euryarchaeota,2NAE8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	ko:K06862	-	-	-	-	ko00000	-	-	-	ACT
XH3_k127_2961823_0	456442.Mboo_1802	6.047e-122	399.0	COG0463@1|root,arCOG00894@2157|Archaea,2XTEG@28890|Euryarchaeota,2N988@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
XH3_k127_2961823_4	593750.Metfor_1336	1.093e-67	237.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
XH3_k127_2961823_6	593750.Metfor_1174	2.742e-23	102.0	arCOG05293@1|root,arCOG05293@2157|Archaea	2157|Archaea	G	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3055120_2	593750.Metfor_2509	7.134e-66	230.0	COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,2N9QS@224756|Methanomicrobia	224756|Methanomicrobia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
XH3_k127_3055120_1	456442.Mboo_0702	9.473e-67	229.0	COG1267@1|root,arCOG01869@2157|Archaea,2XZTX@28890|Euryarchaeota,2NA1N@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Phosphatidylglycerophosphatase A	-	-	-	-	-	-	-	-	-	-	-	-	PgpA
XH3_k127_3055120_0	368407.Memar_0735	1.741e-98	327.0	COG2038@1|root,arCOG04272@2157|Archaea,2XTPU@28890|Euryarchaeota,2N9K1@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3077046_1	593750.Metfor_0681	1.387e-104	345.0	COG0303@1|root,COG1910@1|root,arCOG00217@2157|Archaea,arCOG00230@2157|Archaea,2XT2V@28890|Euryarchaeota,2N9DX@224756|Methanomicrobia	224756|Methanomicrobia	H	MoeA domain protein domain I and II	moeA-1	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
XH3_k127_3077046_2	679926.Mpet_2133	5.777e-44	166.0	COG1611@1|root,arCOG02431@2157|Archaea,2XXTK@28890|Euryarchaeota,2N9VX@224756|Methanomicrobia	224756|Methanomicrobia	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
XH3_k127_3077046_0	368407.Memar_0559	2.284e-114	376.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
XH3_k127_309512_1	593750.Metfor_0366	2.356e-177	576.0	COG1668@1|root,arCOG04450@2157|Archaea,2XTRJ@28890|Euryarchaeota,2N9IA@224756|Methanomicrobia	224756|Methanomicrobia	C	COG1668 ABC-type Na efflux pump, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
XH3_k127_309512_2	593750.Metfor_0368	6.269e-115	377.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUT0@28890|Euryarchaeota,2N9J5@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
XH3_k127_309512_4	456442.Mboo_0725	1.808e-61	221.0	arCOG03165@1|root,arCOG03165@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_309512_0	456442.Mboo_2275	1.099e-198	632.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,2N951@224756|Methanomicrobia	224756|Methanomicrobia	S	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
XH3_k127_309512_3	521011.Mpal_0147	1.566e-81	276.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,2N9JZ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
XH3_k127_309512_5	456442.Mboo_2273	1.716e-53	192.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH3_k127_31006_2	368407.Memar_1298	2.908e-135	442.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,2N97U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
XH3_k127_31006_5	368407.Memar_1299	1.292e-88	301.0	COG0077@1|root,arCOG00255@2157|Archaea,2XTAI@28890|Euryarchaeota,2N9DQ@224756|Methanomicrobia	224756|Methanomicrobia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
XH3_k127_31006_4	456442.Mboo_1560	1.532e-94	317.0	COG0722@1|root,arCOG00245@2157|Archaea,2XU8C@28890|Euryarchaeota,2N9HG@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
XH3_k127_31006_3	456442.Mboo_1559	1.67e-126	412.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
XH3_k127_31006_0	456442.Mboo_1558	5.553e-140	447.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K11645,ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568,R08568	RC00438,RC00439,RC00603,RC00604,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
XH3_k127_31006_1	323259.Mhun_1036	5.765e-137	439.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N93C@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	-	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
XH3_k127_3130240_6	410358.Mlab_1478	7.824e-19	88.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,2N9JT@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
XH3_k127_3130240_3	521011.Mpal_0539	2.5e-35	136.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,2N9YU@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL31 family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
XH3_k127_3130240_7	593750.Metfor_1091	4.048e-18	84.0	COG2167@1|root,arCOG04177@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
XH3_k127_3130240_0	593750.Metfor_1090	3.841e-66	231.0	COG2117@1|root,arCOG00037@2157|Archaea,2XTGQ@28890|Euryarchaeota,2N9S4@224756|Methanomicrobia	224756|Methanomicrobia	J	subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain	-	-	-	ko:K07585	-	-	-	-	ko00000	-	-	-	-
XH3_k127_3130240_2	593750.Metfor_1089	2.941e-41	154.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
XH3_k127_3130240_1	456442.Mboo_1887	3.663e-63	220.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,2N9QY@224756|Methanomicrobia	224756|Methanomicrobia	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
XH3_k127_3130240_5	593750.Metfor_1087	3.628e-21	95.0	COG1534@1|root,arCOG01346@2157|Archaea,2Y6W9@28890|Euryarchaeota,2NA5I@224756|Methanomicrobia	224756|Methanomicrobia	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
XH3_k127_3130240_4	368407.Memar_1975	2.826e-30	122.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota	28890|Euryarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
XH3_k127_3149969_2	593750.Metfor_2707	1.653e-55	198.0	COG1235@1|root,arCOG00499@2157|Archaea,2XTWY@28890|Euryarchaeota,2N9GT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM beta-lactamase domain protein	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
XH3_k127_3149969_3	521011.Mpal_2581	1.936e-32	130.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,2NA0Z@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
XH3_k127_3149969_1	456442.Mboo_0483	1.75e-100	330.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,2N9JI@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
XH3_k127_3149969_0	679926.Mpet_0587	2.076e-287	899.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,2N93B@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0536	AIRS,AIRS_C
XH3_k127_315403_0	456442.Mboo_0665	2.16e-159	507.0	COG0535@1|root,arCOG00956@2157|Archaea,2XU9R@28890|Euryarchaeota,2N96X@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
XH3_k127_315403_1	237368.SCABRO_01859	2.741e-13	71.0	arCOG09503@1|root,33HQ7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_315403_2	456442.Mboo_0664	0.0001409	46.0	arCOG09427@1|root,arCOG09427@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3169662_1	368407.Memar_0967	3.316e-112	368.0	COG0483@1|root,arCOG01349@2157|Archaea,2XUBB@28890|Euryarchaeota,2N9NZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
XH3_k127_3169662_2	456442.Mboo_1350	4.226e-58	204.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,2N9R5@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
XH3_k127_3169662_3	323259.Mhun_0135	4.363e-57	205.0	COG1881@1|root,arCOG04702@2157|Archaea,2XXMX@28890|Euryarchaeota	28890|Euryarchaeota	S	COG1881 Phospholipid-binding protein	pebP	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
XH3_k127_3169662_4	1297742.A176_05269	1.002e-29	123.0	COG0328@1|root,COG0328@2|Bacteria,1MZD1@1224|Proteobacteria,42UI6@68525|delta/epsilon subdivisions,2WQSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Ribonuclease H	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
XH3_k127_3169662_0	593750.Metfor_0981	3.78e-140	449.0	COG0489@1|root,arCOG00585@2157|Archaea,2XTU2@28890|Euryarchaeota,2N9IC@224756|Methanomicrobia	224756|Methanomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
XH3_k127_332412_0	679926.Mpet_2740	8.353e-35	141.0	COG2881@1|root,arCOG03630@2157|Archaea,2XYDD@28890|Euryarchaeota,2NBAT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
XH3_k127_332412_3	1157640.AQWO01000005_gene1965	0.0002925	52.0	2DZA9@1|root,32V71@2|Bacteria,2IF7X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_332412_2	118168.MC7420_3051	1.254e-07	63.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
XH3_k127_332412_1	316067.Geob_1872	1.856e-14	73.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	algA	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K01809,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,FdtA,MannoseP_isomer,NTP_transferase
XH3_k127_3376247_0	593750.Metfor_0455	7.414e-138	446.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,2N92E@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
XH3_k127_3376247_1	593750.Metfor_0454	5.903e-134	430.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,2N9I6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein, Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
XH3_k127_3376247_2	304371.MCP_0067	4.043e-44	166.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,2N9RU@224756|Methanomicrobia	224756|Methanomicrobia	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
XH3_k127_3376247_3	593750.Metfor_0452	7.324e-39	148.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,2N9FC@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM NiFe hydrogenase maturation protein HypF	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
XH3_k127_3438105_5	368407.Memar_2003	2.527e-14	73.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
XH3_k127_3438105_2	368407.Memar_2002	4.059e-114	375.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y7HY@28890|Euryarchaeota,2NBK4@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
XH3_k127_3438105_3	456442.Mboo_1903	3.159e-112	376.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAP1@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
XH3_k127_3438105_1	323259.Mhun_2920	1.702e-180	572.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,2N9CW@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
XH3_k127_3438105_0	593750.Metfor_1293	7.719e-272	847.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,2N9CP@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
XH3_k127_3438105_4	456442.Mboo_1734	3.096e-34	134.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,2N9BW@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
XH3_k127_3438442_2	456442.Mboo_1444	8.567e-23	99.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
XH3_k127_3438442_0	456442.Mboo_1443	3.68e-289	895.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,2N9B4@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
XH3_k127_3438442_1	593750.Metfor_1683	1.248e-87	293.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,2N9FH@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate	cimA	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
XH3_k127_3455734_0	593750.Metfor_0588	0.0	1152.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
XH3_k127_3455734_1	593750.Metfor_0587	1.861e-156	506.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,2N9FF@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis	mfnA	-	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
XH3_k127_3592847_6	368407.Memar_2038	1.578e-67	232.0	COG0388@1|root,arCOG00062@2157|Archaea,2XVVK@28890|Euryarchaeota,2NBG5@224756|Methanomicrobia	224756|Methanomicrobia	S	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase,PAD_porph
XH3_k127_3592847_2	368407.Memar_2440	1.05e-88	301.0	COG0613@1|root,arCOG00302@2157|Archaea,2Y3KK@28890|Euryarchaeota	28890|Euryarchaeota	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
XH3_k127_3592847_0	368407.Memar_0380	1.416e-112	375.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
XH3_k127_3592847_5	868131.MSWAN_0024	1.154e-68	248.0	COG2710@1|root,arCOG00591@2157|Archaea,2XXZF@28890|Euryarchaeota	28890|Euryarchaeota	C	Nitrogenase component 1 type Oxidoreductase	-	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
XH3_k127_3592847_14	368407.Memar_2438	7.998e-16	85.0	arCOG04662@1|root,arCOG04662@2157|Archaea,2XU93@28890|Euryarchaeota,2NBCG@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3592847_8	304371.MCP_1229	4.475e-48	183.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1
XH3_k127_3592847_10	679926.Mpet_2051	2.962e-29	120.0	COG4828@1|root,arCOG03300@2157|Archaea,2Y0K6@28890|Euryarchaeota,2NA5G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
XH3_k127_3592847_4	456442.Mboo_2123	2.774e-74	260.0	COG1606@1|root,arCOG00043@2157|Archaea,2XV2X@28890|Euryarchaeota,2N9N2@224756|Methanomicrobia	224756|Methanomicrobia	S	PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase,QueC
XH3_k127_3592847_3	368407.Memar_1336	1.269e-85	290.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1238	ThiF
XH3_k127_3592847_13	368407.Memar_1335	8.123e-19	89.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
XH3_k127_3592847_9	368407.Memar_1334	7.314e-43	161.0	COG0314@1|root,arCOG00534@2157|Archaea,2XZG1@28890|Euryarchaeota	28890|Euryarchaeota	H	Molybdopterin converting factor	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
XH3_k127_3592847_12	679926.Mpet_2695	8.275e-27	115.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
XH3_k127_3592847_1	323259.Mhun_2495	2.335e-89	309.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
XH3_k127_3592847_11	368407.Memar_1748	1.412e-27	117.0	arCOG06067@1|root,arCOG06067@2157|Archaea	2157|Archaea	S	Phosphate-starvation-inducible E	-	-	-	-	-	-	-	-	-	-	-	-	PsiE
XH3_k127_3592847_7	368407.Memar_2117	5.744e-67	233.0	COG4066@1|root,arCOG03215@2157|Archaea,2Y0A8@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0305 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2115
XH3_k127_3600083_3	323259.Mhun_0919	4.232e-07	51.0	COG2036@1|root,arCOG02144@2157|Archaea	2157|Archaea	K	transcription factor (CBF NF-Y)	hstA	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
XH3_k127_3600083_2	456442.Mboo_0114	2.142e-30	128.0	COG3548@1|root,arCOG04887@2157|Archaea,2XUMU@28890|Euryarchaeota	28890|Euryarchaeota	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
XH3_k127_3600083_0	192952.MM_1626	1.746e-107	357.0	COG2516@1|root,arCOG00662@2157|Archaea,2XV52@28890|Euryarchaeota,2N9EK@224756|Methanomicrobia	224756|Methanomicrobia	S	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH3_k127_3600083_1	563192.HMPREF0179_00336	7.262e-63	226.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,42PAQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	PFAM Amidohydrolase 2	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
XH3_k127_3600083_4	748449.Halha_0954	2.196e-05	47.0	COG4343@1|root,COG4343@2|Bacteria,1TRDE@1239|Firmicutes,24DTN@186801|Clostridia	186801|Clostridia	S	TIGRFAM CRISPR-associated protein	-	-	-	ko:K19085	-	-	-	-	ko00000,ko02048	-	-	-	Csa1
XH3_k127_3621507_3	521011.Mpal_0594	3.99e-61	214.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,2N972@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
XH3_k127_3621507_0	593750.Metfor_0238	1.168e-110	362.0	COG1635@1|root,arCOG00574@2157|Archaea,2XTXH@28890|Euryarchaeota,2N9AS@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur	thi4	-	-	ko:K03146	ko00730,ko01100,map00730,map01100	-	R10685	RC00033,RC03253,RC03254	ko00000,ko00001	-	-	-	Thi4
XH3_k127_3621507_1	593750.Metfor_2876	6.646e-88	294.0	arCOG05313@1|root,arCOG05313@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF1917)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1917
XH3_k127_3621507_4	456442.Mboo_0238	3.44e-22	96.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota,2NB9F@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
XH3_k127_3621507_2	368407.Memar_2248	1.1e-67	235.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,2N9KV@224756|Methanomicrobia	224756|Methanomicrobia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
XH3_k127_3624051_1	521011.Mpal_2646	7.668e-106	351.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,2N925@224756|Methanomicrobia	224756|Methanomicrobia	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
XH3_k127_3624051_0	368407.Memar_2365	5.8e-121	394.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,2N9EZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the HMG-CoA reductase family	hmgA-2	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1972	HMG-CoA_red
XH3_k127_3657796_8	1041930.Mtc_2016	1.835e-47	174.0	COG1321@1|root,arCOG02100@2157|Archaea,2XXXA@28890|Euryarchaeota,2N9RI@224756|Methanomicrobia	224756|Methanomicrobia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
XH3_k127_3657796_2	456442.Mboo_0113	1.927e-136	441.0	COG2255@1|root,arCOG00473@2157|Archaea,2Y1NA@28890|Euryarchaeota,2NAEI@224756|Methanomicrobia	224756|Methanomicrobia	L	Holliday junction DNA helicase ruvB C-terminus	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
XH3_k127_3657796_9	456442.Mboo_0112	1.507e-42	163.0	COG0632@1|root,arCOG06911@2157|Archaea,2Y4CP@28890|Euryarchaeota,2NAY8@224756|Methanomicrobia	224756|Methanomicrobia	L	RuvA, C-terminal domain	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
XH3_k127_3657796_7	456442.Mboo_0111	1.927e-50	186.0	COG0817@1|root,arCOG06910@2157|Archaea,2Y49H@28890|Euryarchaeota,2NB1G@224756|Methanomicrobia	224756|Methanomicrobia	L	Crossover junction endodeoxyribonuclease RuvC	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
XH3_k127_3657796_6	456442.Mboo_1455	5.958e-51	195.0	COG5607@1|root,arCOG05139@2157|Archaea	2157|Archaea	T	CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH,HD,Metallophos_2
XH3_k127_3657796_0	269797.Mbar_A1195	6.03e-220	705.0	COG0855@1|root,arCOG04535@2157|Archaea,2XTCF@28890|Euryarchaeota,2N965@224756|Methanomicrobia	224756|Methanomicrobia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
XH3_k127_3657796_10	593750.Metfor_0644	1.161e-13	76.0	arCOG12340@1|root,arCOG12340@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3657796_5	368407.Memar_1033	1.01e-56	201.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,2N9WI@224756|Methanomicrobia	224756|Methanomicrobia	L	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
XH3_k127_3657796_1	593750.Metfor_2097	5.458e-162	515.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,2N915@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
XH3_k127_3657796_11	368407.Memar_1035	5.045e-08	64.0	arCOG06113@1|root,arCOG06113@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K06193	ko01120,map01120	-	-	-	ko00000	-	-	-	TF_Zn_Ribbon
XH3_k127_3657796_3	593750.Metfor_2095	5.567e-82	282.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,2N9K9@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0788	AA_kinase
XH3_k127_3657796_4	521011.Mpal_1965	4.317e-68	237.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,2N9S3@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
XH3_k127_3664631_3	521011.Mpal_2746	5.428e-31	123.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,2N9A6@224756|Methanomicrobia	224756|Methanomicrobia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
XH3_k127_3664631_1	368407.Memar_0539	9.454e-82	277.0	COG1587@1|root,arCOG02048@2157|Archaea,2Y267@28890|Euryarchaeota,2N9PI@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
XH3_k127_3664631_0	368407.Memar_0538	3.118e-103	346.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
XH3_k127_3664631_2	593750.Metfor_2676	1.229e-37	143.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
XH3_k127_3665971_4	368407.Memar_1773	1.643e-55	202.0	COG2968@1|root,arCOG04715@2157|Archaea,2XZAZ@28890|Euryarchaeota,2N9TF@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
XH3_k127_3665971_3	593750.Metfor_0780	2.861e-57	203.0	COG0195@1|root,arCOG01760@2157|Archaea	2157|Archaea	K	transcription termination protein NusA	nusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
XH3_k127_3665971_7	593750.Metfor_0781	5.088e-27	112.0	COG0140@1|root,arCOG02677@2157|Archaea,2XYNB@28890|Euryarchaeota,2NA17@224756|Methanomicrobia	224756|Methanomicrobia	E	phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
XH3_k127_3665971_5	368407.Memar_1780	1.95e-43	165.0	COG1259@1|root,arCOG01759@2157|Archaea,2XWIM@28890|Euryarchaeota,2NA0M@224756|Methanomicrobia	224756|Methanomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
XH3_k127_3665971_1	368407.Memar_1781	3.64e-119	392.0	COG0392@1|root,arCOG00899@2157|Archaea,2XY3K@28890|Euryarchaeota,2NATI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
XH3_k127_3665971_6	456442.Mboo_2069	1.731e-33	139.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,2NA0B@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
XH3_k127_3665971_2	521011.Mpal_0116	6.496e-94	315.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
XH3_k127_3665971_0	368407.Memar_1784	6.397e-139	451.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
XH3_k127_3677815_3	593750.Metfor_0773	5.748e-14	78.0	COG2710@1|root,arCOG00593@2157|Archaea	2157|Archaea	C	PFAM oxidoreductase nitrogenase, component 1	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_nitro
XH3_k127_3677815_2	410358.Mlab_0164	5.192e-70	250.0	COG2710@1|root,arCOG00598@2157|Archaea	2157|Archaea	C	PFAM oxidoreductase nitrogenase, component 1	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_nitro
XH3_k127_3677815_0	593750.Metfor_0771	2.535e-129	417.0	COG1348@1|root,arCOG00590@2157|Archaea,2XUNI@28890|Euryarchaeota,2NBI4@224756|Methanomicrobia	224756|Methanomicrobia	D	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
XH3_k127_3677815_1	593750.Metfor_0769	5.643e-86	292.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
XH3_k127_3690205_1	456442.Mboo_1725	3.168e-169	539.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,2N94X@224756|Methanomicrobia	224756|Methanomicrobia	J	TGS domain protein	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
XH3_k127_3690205_3	368407.Memar_1576	1.108e-91	304.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,2N9M4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
XH3_k127_3690205_5	368407.Memar_1575	9.904e-48	184.0	arCOG04389@1|root,arCOG04389@2157|Archaea,2XWXD@28890|Euryarchaeota	28890|Euryarchaeota	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3690205_2	368407.Memar_1573	1.448e-123	410.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
XH3_k127_3690205_0	456442.Mboo_1721	0.0	1296.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
XH3_k127_3690205_4	593750.Metfor_1274	1.079e-61	216.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2N9Y8@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
XH3_k127_3696752_0	243231.GSU0804	1.698e-89	308.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the WrbA family	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0771	FMN_red
XH3_k127_3705024_6	323259.Mhun_0502	1.996e-13	69.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,2N958@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
XH3_k127_3705024_3	323259.Mhun_1244	2.872e-110	361.0	COG2013@1|root,arCOG01907@2157|Archaea,2XW0I@28890|Euryarchaeota	28890|Euryarchaeota	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
XH3_k127_3705024_4	593750.Metfor_2881	6.335e-35	134.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3705024_5	593750.Metfor_1125	5.378e-16	79.0	arCOG12704@1|root,arCOG12704@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3705024_2	323259.Mhun_0672	7.802e-152	483.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,2N9CI@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
XH3_k127_3705024_0	593750.Metfor_1747	3.571e-189	601.0	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,2N96K@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source	cbiA-1	-	6.3.5.12	ko:K22012	ko00860,map00860	M00836	R11627	-	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
XH3_k127_3705024_1	368407.Memar_1733	1.678e-161	513.0	COG2710@1|root,arCOG04888@2157|Archaea,2XUYC@28890|Euryarchaeota,2N90I@224756|Methanomicrobia	224756|Methanomicrobia	C	Methanogenesis marker 13 metalloprotein	-	-	6.3.3.7	ko:K21611	ko00860,ko01120,map00860,map01120	M00836	R11628	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
XH3_k127_3725439_2	593750.Metfor_1041	1.753e-207	652.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
XH3_k127_3725439_8	456442.Mboo_1926	2.555e-36	139.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y12M@28890|Euryarchaeota,2N9YP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3725439_4	456442.Mboo_1927	5.858e-109	357.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
XH3_k127_3725439_7	521011.Mpal_0693	6.725e-40	153.0	COG1935@1|root,arCOG04420@2157|Archaea,2Y1FM@28890|Euryarchaeota,2NA37@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF473)	-	-	-	ko:K09135	-	-	-	-	ko00000	-	-	-	DUF473
XH3_k127_3725439_5	521011.Mpal_2164	1.751e-70	241.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2N9SC@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription termination protein NusA	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
XH3_k127_3725439_6	456442.Mboo_1930	6.141e-42	157.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,2NA2A@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein L7Ae L30e S12e Gadd45	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
XH3_k127_3725439_3	456442.Mboo_1931	5.41e-202	633.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,2N927@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
XH3_k127_3725439_0	593750.Metfor_1029	0.0	1603.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,2N96G@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
XH3_k127_3725439_1	456442.Mboo_1933	1.255e-315	970.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,2N93R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB2	-	2.7.7.6	ko:K03044	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
XH3_k127_3733917_6	521011.Mpal_1982	6.769e-10	59.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,2N9X7@224756|Methanomicrobia	224756|Methanomicrobia	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
XH3_k127_3733917_0	456442.Mboo_0263	0.0	1257.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,2N9FS@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
XH3_k127_3733917_1	456442.Mboo_0264	3.193e-86	289.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,2N9K7@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
XH3_k127_3733917_4	29078.XP_008160308.1	1.611e-34	136.0	COG0048@1|root,KOG1749@2759|Eukaryota,39ZWD@33154|Opisthokonta,3BPBM@33208|Metazoa,3CU4X@33213|Bilateria,488JW@7711|Chordata,4921H@7742|Vertebrata,3J51S@40674|Mammalia,4M2U7@9397|Chiroptera	33208|Metazoa	J	Ribosomal protein S23	RPS23	-	-	ko:K02973	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
XH3_k127_3733917_3	521011.Mpal_0282	2.764e-55	200.0	COG0720@1|root,arCOG02172@2157|Archaea,2XX1X@28890|Euryarchaeota,2NBDZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM 6-pyruvoyl tetrahydropterin synthase and	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
XH3_k127_3733917_2	593750.Metfor_2836	1.576e-83	282.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,2N9MX@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
XH3_k127_3733917_5	593750.Metfor_2837	8.989e-20	91.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,2N9IW@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
XH3_k127_3741506_0	368407.Memar_1998	2.291e-140	455.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
XH3_k127_3741506_4	456442.Mboo_1902	5.487e-56	196.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,2N9W4@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
XH3_k127_3741506_7	456442.Mboo_2233	1.055e-26	113.0	COG3364@1|root,arCOG04417@2157|Archaea,2Y0WK@28890|Euryarchaeota,2N9ZI@224756|Methanomicrobia	224756|Methanomicrobia	S	Zn-ribbon containing protein	-	-	-	ko:K07163	-	-	-	-	ko00000	-	-	-	DUF2072
XH3_k127_3741506_6	368407.Memar_1792	1.576e-45	167.0	COG3365@1|root,arCOG04416@2157|Archaea,2XX2F@28890|Euryarchaeota,2N9XF@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2073)	-	-	-	ko:K09743	-	-	-	-	ko00000	-	-	-	DUF2073
XH3_k127_3741506_1	456442.Mboo_2232	4.473e-105	344.0	COG1100@1|root,arCOG00354@2157|Archaea,2XT36@28890|Euryarchaeota,2N9A5@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GTP-binding protein HSR1-related	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	MMR_HSR1
XH3_k127_3741506_2	368407.Memar_1794	2.422e-78	266.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
XH3_k127_3741506_3	521011.Mpal_2666	5.812e-74	257.0	COG0517@1|root,arCOG00602@2157|Archaea,2XYM5@28890|Euryarchaeota,2N9RH@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
XH3_k127_3741506_5	593750.Metfor_0471	7.255e-47	170.0	COG0517@1|root,arCOG00600@2157|Archaea,2XX02@28890|Euryarchaeota,2N9I1@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
XH3_k127_3771155_5	593750.Metfor_1256	2.543e-61	215.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,2N96I@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM bifunctional deaminase-reductase domain protein	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
XH3_k127_3771155_4	456442.Mboo_0036	1.835e-65	229.0	COG1280@1|root,arCOG01947@2157|Archaea,2XY47@28890|Euryarchaeota,2N9SP@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
XH3_k127_3771155_0	593750.Metfor_0371	2.384e-159	518.0	COG1907@1|root,COG3161@1|root,arCOG01026@2157|Archaea,arCOG01031@2157|Archaea,2XUFK@28890|Euryarchaeota,2N92U@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P)	-	-	2.4.2.54	ko:K06984	ko00790,map00790	-	R10337,R11102	-	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0806	DUF98,GHMP_kinases_C,GHMP_kinases_N
XH3_k127_3771155_6	593750.Metfor_1980	1.033e-50	183.0	arCOG14251@1|root,arCOG14251@2157|Archaea	2157|Archaea	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
XH3_k127_3771155_2	456442.Mboo_0644	3.136e-77	267.0	COG0727@1|root,arCOG02581@2157|Archaea,2XWRY@28890|Euryarchaeota,2N9HZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
XH3_k127_3771155_3	247490.KSU1_D0164	1.109e-68	236.0	COG0590@1|root,COG0590@2|Bacteria,2IZBJ@203682|Planctomycetes	203682|Planctomycetes	FJ	COG0590 Cytosine adenosine deaminases	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
XH3_k127_3771155_1	593750.Metfor_2901	2.42e-97	325.0	COG3527@1|root,arCOG03340@2157|Archaea,2XUAU@28890|Euryarchaeota,2NARS@224756|Methanomicrobia	224756|Methanomicrobia	Q	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
XH3_k127_3771155_7	521011.Mpal_2207	3.346e-19	90.0	COG2404@1|root,arCOG00423@2157|Archaea,2XTAE@28890|Euryarchaeota	28890|Euryarchaeota	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
XH3_k127_3789137_1	323259.Mhun_0924	1.282e-56	207.0	COG0500@1|root,arCOG03411@2157|Archaea,2XVFA@28890|Euryarchaeota,2NAYR@224756|Methanomicrobia	224756|Methanomicrobia	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
XH3_k127_3789137_0	521011.Mpal_1744	3.588e-196	617.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,2N9CD@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
XH3_k127_3789137_2	456442.Mboo_1065	3.233e-33	132.0	COG0040@1|root,arCOG02208@2157|Archaea,2XTZ3@28890|Euryarchaeota,2N9AD@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
XH3_k127_3813745_0	593750.Metfor_1984	1.55e-118	391.0	COG0534@1|root,arCOG01731@2157|Archaea,2XU54@28890|Euryarchaeota,2NA9K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM multi antimicrobial extrusion protein MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
XH3_k127_3813745_1	44454.NF84_14150	2.722e-114	377.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,234HP@1762|Mycobacteriaceae	201174|Actinobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
XH3_k127_3858946_5	323259.Mhun_2581	9.567e-38	144.0	COG1320@1|root,arCOG03082@2157|Archaea,2XZ52@28890|Euryarchaeota,2NBDI@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
XH3_k127_3858946_6	323259.Mhun_2580	3.667e-24	103.0	COG2212@1|root,arCOG03121@2157|Archaea,2Y0XI@28890|Euryarchaeota	28890|Euryarchaeota	P	Multisubunit Na H antiporter, MnhF subunit	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
XH3_k127_3858946_2	323259.Mhun_2579	2.6e-59	210.0	COG1863@1|root,arCOG03099@2157|Archaea,2XYYP@28890|Euryarchaeota	28890|Euryarchaeota	P	Multisubunit Na H antiporter MnhE subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
XH3_k127_3858946_0	593750.Metfor_2045	5.679e-196	623.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
XH3_k127_3858946_1	593750.Metfor_2044	1.476e-85	287.0	COG0118@1|root,arCOG00089@2157|Archaea,2XTJ7@28890|Euryarchaeota,2N9N4@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
XH3_k127_3858946_4	323259.Mhun_0041	5.171e-40	158.0	arCOG06913@1|root,arCOG06913@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3858946_3	456442.Mboo_1266	1.876e-58	209.0	COG0640@1|root,arCOG01686@2157|Archaea,2XX9R@28890|Euryarchaeota,2N9WK@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
XH3_k127_3886680_1	521011.Mpal_2371	1.214e-182	581.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,2N9CR@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
XH3_k127_3886680_2	368407.Memar_1816	2.127e-132	429.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
XH3_k127_3886680_0	456442.Mboo_2210	3.714e-207	647.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
XH3_k127_3904785_2	593750.Metfor_0332	2.089e-113	375.0	arCOG02780@1|root,arCOG02780@2157|Archaea,2XZQI@28890|Euryarchaeota,2N9W5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3904785_0	456442.Mboo_2329	4.116e-143	466.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2
XH3_k127_3904785_1	639282.DEFDS_0235	1.251e-127	426.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GF76@200930|Deferribacteres	200930|Deferribacteres	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
XH3_k127_3904785_3	322710.Avin_17840	1.89e-11	71.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria	1224|Proteobacteria	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU_div
XH3_k127_3911193_1	593750.Metfor_2507	1.606e-85	288.0	COG2038@1|root,arCOG04272@2157|Archaea,2XTPU@28890|Euryarchaeota,2N9K1@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_3911193_2	521011.Mpal_1547	7.294e-82	275.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,2N9KA@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
XH3_k127_3911193_3	368407.Memar_0737	2.608e-47	175.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
XH3_k127_3911193_0	593750.Metfor_1488	4.149e-158	507.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
XH3_k127_3911193_4	323259.Mhun_0651	2.142e-21	98.0	COG1409@1|root,arCOG01144@2157|Archaea	2157|Archaea	G	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
XH3_k127_3921131_0	456442.Mboo_0063	6.038e-213	663.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,2N98B@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
XH3_k127_3921131_1	593750.Metfor_0088	2.016e-87	297.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota	28890|Euryarchaeota	S	ATP-NAD AcoX kinase	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
XH3_k127_40103_2	521011.Mpal_2373	1.327e-95	319.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
XH3_k127_40103_0	593750.Metfor_0497	1.102e-142	460.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,2N94G@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
XH3_k127_40103_3	593750.Metfor_0496	4.24e-83	284.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,2N9PA@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
XH3_k127_40103_1	368407.Memar_1812	7.165e-130	420.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2N96Q@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
XH3_k127_40103_4	593750.Metfor_0494	8.443e-67	231.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,2N9H3@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
XH3_k127_4094346_3	521011.Mpal_0684	2.708e-57	202.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,2N9HM@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM triphosphoribosyl-dephospho-CoA protein	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
XH3_k127_4094346_0	521011.Mpal_0683	2.212e-168	536.0	COG0042@1|root,arCOG00605@2157|Archaea,2XU1I@28890|Euryarchaeota,2N9FE@224756|Methanomicrobia	224756|Methanomicrobia	J	Dihydrouridine synthase (Dus)	-	-	-	-	-	-	-	-	-	-	-	-	Dus
XH3_k127_4094346_2	456442.Mboo_1417	9.909e-59	205.0	COG2138@1|root,arCOG02246@2157|Archaea,2XTSY@28890|Euryarchaeota,2N9W8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin	cbiX	-	4.99.1.11,4.99.1.3	ko:K22011	ko00860,ko01100,map00860,map01100	M00836	R05807,R11626	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2400	CbiX
XH3_k127_4094346_1	368407.Memar_1732	4.823e-114	379.0	COG0770@1|root,arCOG02822@2157|Archaea,2XX2Y@28890|Euryarchaeota,2N9JG@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Mur ligase, middle domain protein	murD	-	6.4.1.9	ko:K21612	ko00860,ko01120,map00860,map01120	M00836	R11629	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
XH3_k127_4160714_2	877455.Metbo_0056	3.488e-28	121.0	arCOG09452@1|root,arCOG09452@2157|Archaea,2Y0CR@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4160714_0	1210908.HSB1_19360	1.318e-103	344.0	COG0596@1|root,arCOG07416@1|root,arCOG01648@2157|Archaea,arCOG07416@2157|Archaea,2XUEK@28890|Euryarchaeota,23U6U@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
XH3_k127_4160714_1	1278307.KB907000_gene320	2.819e-30	130.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,1THEU@1236|Gammaproteobacteria,2QIPW@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4162930_5	368407.Memar_1205	1.034e-07	55.0	COG1917@1|root,arCOG03004@2157|Archaea,2XYUR@28890|Euryarchaeota,2NB2H@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
XH3_k127_4162930_0	593750.Metfor_1949	9.026e-71	248.0	COG0348@1|root,arCOG02772@2157|Archaea,2Y033@28890|Euryarchaeota,2NA32@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
XH3_k127_4162930_2	593750.Metfor_2084	7.988e-50	179.0	COG1917@1|root,arCOG02992@2157|Archaea,2XZHW@28890|Euryarchaeota,2NAZU@224756|Methanomicrobia	224756|Methanomicrobia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
XH3_k127_4162930_1	368407.Memar_1258	1.591e-52	192.0	COG4079@1|root,arCOG03213@2157|Archaea,2XW0G@28890|Euryarchaeota,2NAV2@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2121)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2121
XH3_k127_4162930_3	521011.Mpal_1953	1.047e-30	124.0	arCOG03390@1|root,arCOG03390@2157|Archaea,2Y08K@28890|Euryarchaeota,2N9YI@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4162930_4	456442.Mboo_2259	2.955e-18	85.0	arCOG02290@1|root,arCOG02290@2157|Archaea,2XWJW@28890|Euryarchaeota,2N9PB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
XH3_k127_4171482_3	1121396.KB893074_gene3016	7.923e-28	113.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N5U@68525|delta/epsilon subdivisions,2X5GU@28221|Deltaproteobacteria,2MQ3E@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ABC 3 transport family	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
XH3_k127_4171482_1	269797.Mbar_A2394	1.488e-90	307.0	COG1120@1|root,arCOG00198@2157|Archaea,2Y83I@28890|Euryarchaeota,2NACA@224756|Methanomicrobia	224756|Methanomicrobia	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	iAF692.Mbar_A2394	ABC_tran
XH3_k127_4171482_0	679926.Mpet_0513	1.095e-118	395.0	COG0614@1|root,arCOG03309@2157|Archaea,2Y8CN@28890|Euryarchaeota,2NB7A@224756|Methanomicrobia	224756|Methanomicrobia	P	COGs COG0614 ABC-type Fe3 -hydroxamate transport system periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
XH3_k127_4171482_2	304371.MCP_0988	5.545e-33	130.0	arCOG01638@1|root,arCOG01638@2157|Archaea,2Y3ZV@28890|Euryarchaeota,2NB2D@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
XH3_k127_4186019_0	456442.Mboo_2156	6.37e-159	506.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,2N968@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
XH3_k127_4186019_1	368407.Memar_1862	3.386e-99	334.0	COG4069@1|root,arCOG03231@2157|Archaea,2XV7V@28890|Euryarchaeota,2N9V3@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2117
XH3_k127_4212939_1	593750.Metfor_2165	1.007e-65	230.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,2N9IK@224756|Methanomicrobia	224756|Methanomicrobia	L	SMART DNA-directed DNA polymerase B	polB-1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
XH3_k127_4212939_0	521011.Mpal_1741	2.862e-112	371.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the LDH MDH superfamily	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
XH3_k127_4212939_2	521011.Mpal_1742	0.0001109	47.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
XH3_k127_4275364_2	679926.Mpet_1051	6.53e-21	94.0	arCOG09272@1|root,arCOG09272@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4275364_1	368407.Memar_1382	2.513e-50	183.0	arCOG05305@1|root,arCOG05305@2157|Archaea,2Y5MK@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4275364_0	323259.Mhun_1813	1.362e-205	643.0	COG0243@1|root,arCOG01491@2157|Archaea,2XT94@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing	narB	-	1.17.1.9,1.20.2.1,1.20.9.1,1.7.7.2	ko:K00123,ko:K00367,ko:K00372,ko:K08356	ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,map00630,map00680,map00910,map01100,map01120,map01200	M00531	R00519,R00791,R00798,R01106	RC02796,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.6	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
XH3_k127_4332731_3	593750.Metfor_2030	1.298e-64	224.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,2N9MS@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
XH3_k127_4332731_0	593750.Metfor_2029	4.748e-125	409.0	COG2232@1|root,arCOG01595@2157|Archaea,2XXHX@28890|Euryarchaeota,2N9KN@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
XH3_k127_4332731_2	456442.Mboo_1279	1.437e-70	247.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2N9WY@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
XH3_k127_4332731_4	456442.Mboo_1280	6.033e-46	171.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
XH3_k127_4332731_1	593750.Metfor_2026	6.869e-71	243.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,2N9NE@224756|Methanomicrobia	224756|Methanomicrobia	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
XH3_k127_4372032_1	593750.Metfor_2579	3.39e-37	143.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Archaeal protein of	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
XH3_k127_4372032_2	521011.Mpal_1002	4.228e-35	141.0	COG2062@1|root,arCOG01992@2157|Archaea,2Y26Y@28890|Euryarchaeota	28890|Euryarchaeota	T	TIGRFAM phosphohistidine phosphatase SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
XH3_k127_4372032_0	386456.JQKN01000010_gene663	4.38e-70	246.0	COG1719@1|root,arCOG01688@2157|Archaea,2XYSH@28890|Euryarchaeota,23P5X@183925|Methanobacteria	183925|Methanobacteria	K	transcriptional regulator, ArsR family	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	HTH_5,V4R
XH3_k127_4372032_3	521011.Mpal_2235	1.026e-18	85.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	fwdB-1	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
XH3_k127_4381320_1	456442.Mboo_0181	1.212e-108	359.0	COG1865@1|root,COG2158@1|root,arCOG01870@2157|Archaea,arCOG05056@2157|Archaea,2XUDZ@28890|Euryarchaeota,2N9UT@224756|Methanomicrobia	224756|Methanomicrobia	H	Cysteine-rich small domain	cbiZ	-	3.5.1.90	ko:K08260	ko00860,ko01100,map00860,map01100	-	R05226	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CbiZ,zf-like
XH3_k127_4381320_3	593750.Metfor_0012	2.681e-25	105.0	arCOG05294@1|root,arCOG05294@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
XH3_k127_4381320_0	593750.Metfor_0013	1.588e-174	556.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTYM@28890|Euryarchaeota,2N9GI@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
XH3_k127_4381320_2	521011.Mpal_0023	3.133e-83	280.0	COG3390@1|root,arCOG02257@2157|Archaea,2XTM4@28890|Euryarchaeota,2N9JC@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
XH3_k127_4381320_5	593750.Metfor_2782	5.184e-19	88.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	DnaJ,Fer4_13,Fer4_15
XH3_k127_4381320_4	593750.Metfor_0020	1.481e-21	94.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,2N9HB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1524	DHBP_synthase
XH3_k127_4425171_5	593750.Metfor_2885	3.568e-19	92.0	arCOG09577@1|root,arCOG09577@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4425171_4	485913.Krac_8476	1.468e-21	100.0	COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi	200795|Chloroflexi	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
XH3_k127_4425171_1	1094980.Mpsy_3086	0.0	1074.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,2N96P@224756|Methanomicrobia	224756|Methanomicrobia	E	Domain of unknown function (DUF3458_C) ARM repeats	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
XH3_k127_4425171_3	679926.Mpet_0156	8.712e-42	162.0	arCOG04662@1|root,arCOG04662@2157|Archaea,2XU93@28890|Euryarchaeota,2NBCG@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4425171_0	521011.Mpal_0225	0.0	1172.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
XH3_k127_4465947_0	323259.Mhun_0342	1.999e-260	814.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAFK@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
XH3_k127_4490985_0	388467.A19Y_0199	1.133e-77	269.0	COG0438@1|root,COG0457@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,1FZUY@1117|Cyanobacteria,1HI7Q@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,TPR_11,TPR_2,TPR_7,TPR_8
XH3_k127_4490985_2	244447.XP_008322554.1	5.578e-16	88.0	KOG4179@1|root,KOG4179@2759|Eukaryota,38BZB@33154|Opisthokonta,3BB9G@33208|Metazoa,3CT83@33213|Bilateria,47Z13@7711|Chordata,48W32@7742|Vertebrata,49X8B@7898|Actinopterygii	33208|Metazoa	O	Cerebral endothelial cell adhesion molecule	CERCAM	GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0007159,GO:0008150,GO:0016020,GO:0022610,GO:0044464,GO:0071944,GO:0098609	2.4.1.50	ko:K11703	ko00310,ko00514,map00310,map00514	-	R03380	RC00005,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT25	-	Glyco_tranf_2_4,Glyco_transf_25
XH3_k127_4490985_1	1173028.ANKO01000112_gene4872	1.285e-63	225.0	COG1216@1|root,COG1216@2|Bacteria,1G2VA@1117|Cyanobacteria,1H9E5@1150|Oscillatoriales	1117|Cyanobacteria	S	involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2
XH3_k127_4509646_2	269797.Mbar_A0582	1.344e-34	144.0	COG3271@1|root,arCOG06761@2157|Archaea,2Y40P@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase C39 family	-	-	-	ko:K06992	-	-	-	-	ko00000	-	-	-	Peptidase_C39_2
XH3_k127_4509646_1	157072.XP_008879442.1	3.738e-45	175.0	2CXWS@1|root,2S0BR@2759|Eukaryota	2759|Eukaryota	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
XH3_k127_4509646_3	456442.Mboo_0146	8.651e-26	113.0	arCOG12674@1|root,arCOG12674@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4509646_0	456442.Mboo_0145	1.422e-224	704.0	COG0531@1|root,arCOG00009@2157|Archaea,2XUU6@28890|Euryarchaeota,2NAJQ@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM amino acid permease-associated region	-	-	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
XH3_k127_4509646_4	456442.Mboo_0144	4.756e-20	89.0	COG1982@1|root,arCOG00092@2157|Archaea	2157|Archaea	E	PFAM Orn Lys Arg decarboxylase major region	-	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
XH3_k127_4547473_1	368407.Memar_0008	1.635e-106	353.0	COG1270@1|root,arCOG04274@2157|Archaea,2XT37@28890|Euryarchaeota,2N9JD@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
XH3_k127_4547473_3	456442.Mboo_0005	3.043e-17	85.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,2NA4S@224756|Methanomicrobia	224756|Methanomicrobia	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
XH3_k127_4547473_0	593750.Metfor_0175	9.638e-176	555.0	COG0104@1|root,arCOG04387@2157|Archaea,2XT59@28890|Euryarchaeota,2N9T2@224756|Methanomicrobia	224756|Methanomicrobia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
XH3_k127_4547473_2	521011.Mpal_0003	6.375e-51	182.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N95M@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	iAF692.Mbar_A3463	Aminotran_1_2
XH3_k127_4581177_3	368407.Memar_1656	1.647e-24	104.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,2N9BA@224756|Methanomicrobia	224756|Methanomicrobia	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
XH3_k127_4581177_2	521011.Mpal_1024	1.198e-34	135.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZ0C@28890|Euryarchaeota,2NB68@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
XH3_k127_4581177_0	593750.Metfor_1333	1.197e-89	301.0	COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,2N9SI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
XH3_k127_4581177_1	521011.Mpal_1027	2.185e-61	216.0	COG0235@1|root,arCOG04226@2157|Archaea,2XYQT@28890|Euryarchaeota,2N9R0@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
XH3_k127_4606297_0	323259.Mhun_1785	3.143e-114	376.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,2N9A9@224756|Methanomicrobia	224756|Methanomicrobia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
XH3_k127_4606297_1	323259.Mhun_1786	6.18e-76	258.0	COG0512@1|root,arCOG00086@2157|Archaea,2XTES@28890|Euryarchaeota,2N9PV@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
XH3_k127_4606297_2	593750.Metfor_2888	7.039e-42	157.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,2N9AU@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
XH3_k127_4641017_1	706587.Desti_1050	6.464e-62	223.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2MRTH@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
XH3_k127_4641017_0	269797.Mbar_A3070	7.582e-124	409.0	COG0025@1|root,arCOG01961@2157|Archaea,2Y0UK@28890|Euryarchaeota,2NBGR@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
XH3_k127_4641017_2	118161.KB235922_gene4915	8.965e-50	194.0	COG0038@1|root,COG0038@2|Bacteria,1G2XJ@1117|Cyanobacteria,3VIXH@52604|Pleurocapsales	1117|Cyanobacteria	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
XH3_k127_4644353_3	456442.Mboo_2187	6.009e-65	224.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,2N90U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
XH3_k127_4644353_0	521011.Mpal_0744	2.254e-113	373.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,2N9EP@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
XH3_k127_4644353_2	456442.Mboo_2189	1.132e-92	313.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y879@28890|Euryarchaeota,2N9M1@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
XH3_k127_4644353_1	456442.Mboo_2190	1.816e-100	334.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
XH3_k127_4644353_4	456442.Mboo_0774	2.722e-10	62.0	arCOG12687@1|root,arCOG12687@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4663045_7	456442.Mboo_0774	5.214e-22	96.0	arCOG12687@1|root,arCOG12687@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4663045_4	456442.Mboo_2198	9.44e-68	237.0	COG1920@1|root,arCOG04472@2157|Archaea,2XX3C@28890|Euryarchaeota,2N9RG@224756|Methanomicrobia	224756|Methanomicrobia	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
XH3_k127_4663045_1	368407.Memar_1838	1.631e-147	481.0	COG1060@1|root,arCOG00657@2157|Archaea,2XT78@28890|Euryarchaeota,2N94M@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofG	-	2.5.1.77	ko:K11780	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
XH3_k127_4663045_3	456442.Mboo_2202	4.018e-90	302.0	COG0152@1|root,arCOG04421@2157|Archaea,2XUKC@28890|Euryarchaeota,2N9F8@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosylaminoimidazolesuccinocarboxamide synthase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
XH3_k127_4663045_6	368407.Memar_1840	1.496e-22	98.0	COG1828@1|root,arCOG04462@2157|Archaea,2XYPB@28890|Euryarchaeota,2NA2T@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
XH3_k127_4663045_2	679926.Mpet_0717	5.081e-108	354.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,2N9HC@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
XH3_k127_4663045_5	593750.Metfor_0517	6.976e-33	130.0	COG4802@1|root,arCOG01099@2157|Archaea,2Y0XX@28890|Euryarchaeota,2NA12@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
XH3_k127_4663045_0	456442.Mboo_2205	1.032e-182	586.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,2N9FG@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ABC-1 domain protein	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
XH3_k127_4671583_1	593750.Metfor_1465	4.471e-201	646.0	COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota,2N91Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
XH3_k127_4671583_0	368407.Memar_1950	7.303e-231	758.0	COG0249@1|root,arCOG02897@2157|Archaea,2XT0M@28890|Euryarchaeota,2N9EU@224756|Methanomicrobia	224756|Methanomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
XH3_k127_4702882_2	456442.Mboo_0501	7.329e-28	115.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,2N9GQ@224756|Methanomicrobia	224756|Methanomicrobia	J	SMART Elongator protein 3 MiaB NifB	miaB	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
XH3_k127_4702882_1	593750.Metfor_2680	1.95e-58	210.0	arCOG05307@1|root,arCOG05307@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4702882_3	521011.Mpal_2760	6.594e-25	110.0	arCOG06929@1|root,arCOG06929@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4702882_0	593750.Metfor_2678	1.995e-140	449.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,2N93H@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
XH3_k127_473015_2	368407.Memar_0976	1.193e-60	216.0	COG2339@1|root,arCOG02985@2157|Archaea	2157|Archaea	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
XH3_k127_473015_0	1047013.AQSP01000110_gene67	2.12e-128	419.0	COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
XH3_k127_473015_1	192952.MM_0383	2.315e-74	256.0	COG5658@1|root,arCOG04484@2157|Archaea,2XVWE@28890|Euryarchaeota,2NB7Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
XH3_k127_473015_3	573413.Spirs_4212	2.009e-29	126.0	COG0242@1|root,COG0242@2|Bacteria	2|Bacteria	J	peptide deformylase activity	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	HTH_31,Pep_deformylase
XH3_k127_4730294_2	593750.Metfor_0992	1.878e-56	198.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,2N90F@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
XH3_k127_4730294_1	593750.Metfor_0993	7.189e-62	216.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,2N9VD@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
XH3_k127_4730294_0	521011.Mpal_0950	9.7e-86	292.0	COG1397@1|root,arCOG04448@2157|Archaea,2XV15@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
XH3_k127_4730294_3	323259.Mhun_1134	1.879e-30	123.0	COG1745@1|root,arCOG02254@2157|Archaea	2157|Archaea	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
XH3_k127_4732184_1	643562.Daes_2884	1.943e-47	176.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2WJ06@28221|Deltaproteobacteria,2M85R@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
XH3_k127_4732184_0	593750.Metfor_0681	5.959e-146	472.0	COG0303@1|root,COG1910@1|root,arCOG00217@2157|Archaea,arCOG00230@2157|Archaea,2XT2V@28890|Euryarchaeota,2N9DX@224756|Methanomicrobia	224756|Methanomicrobia	H	MoeA domain protein domain I and II	moeA-1	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
XH3_k127_4746653_0	456442.Mboo_0658	9.788e-245	767.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
XH3_k127_4746653_1	368407.Memar_0643	1.134e-215	678.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,2N94C@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
XH3_k127_4746653_2	593750.Metfor_2551	2.993e-201	633.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
XH3_k127_4746653_3	368407.Memar_0641	2.204e-120	396.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,2N92W@224756|Methanomicrobia	224756|Methanomicrobia	J	sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
XH3_k127_4746653_4	456442.Mboo_0654	4.871e-116	379.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
XH3_k127_4746653_5	368407.Memar_0637	6.615e-54	192.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N94T@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	aksF	-	1.1.1.87	ko:K10978	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R01934,R01936,R04862,R08214,R08215	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
XH3_k127_4747576_5	521011.Mpal_0778	1.476e-38	146.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
XH3_k127_4747576_0	456442.Mboo_1383	8.792e-135	436.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2N994@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
XH3_k127_4747576_4	521011.Mpal_0780	4.495e-46	170.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia	224756|Methanomicrobia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
XH3_k127_4747576_2	456442.Mboo_1381	1.038e-116	386.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,2N9II@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	A_deaminase,Amidohydro_1
XH3_k127_4747576_7	593750.Metfor_1829	1.338e-14	74.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y6WB@28890|Euryarchaeota,2NA5T@224756|Methanomicrobia	224756|Methanomicrobia	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
XH3_k127_4747576_3	593750.Metfor_1830	1.146e-114	375.0	COG1478@1|root,arCOG02714@2157|Archaea,2XTHI@28890|Euryarchaeota,2N9KE@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
XH3_k127_4747576_6	456442.Mboo_1379	9.827e-32	129.0	arCOG05509@1|root,arCOG05509@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1922
XH3_k127_4747576_8	679926.Mpet_1203	2.438e-14	74.0	COG1096@1|root,arCOG00676@2157|Archaea	2157|Archaea	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
XH3_k127_4747576_1	593750.Metfor_1527	2.748e-119	390.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,2N91R@224756|Methanomicrobia	224756|Methanomicrobia	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
XH3_k127_4762990_6	323259.Mhun_2734	8.099e-34	130.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota,2N9HS@224756|Methanomicrobia	224756|Methanomicrobia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
XH3_k127_4762990_2	456442.Mboo_0077	5.183e-98	324.0	COG0655@1|root,arCOG02574@2157|Archaea	2157|Archaea	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
XH3_k127_4762990_3	456442.Mboo_0076	2.426e-93	311.0	COG0655@1|root,arCOG02572@2157|Archaea,2Y8HN@28890|Euryarchaeota	28890|Euryarchaeota	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
XH3_k127_4762990_0	593750.Metfor_0937	2.478e-180	571.0	COG1122@1|root,arCOG00203@2157|Archaea,2Y7N4@28890|Euryarchaeota,2N9IS@224756|Methanomicrobia	224756|Methanomicrobia	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	iAF692.Mbar_A2149	ABC_tran
XH3_k127_4762990_1	593750.Metfor_0936	1.99e-104	348.0	COG0619@1|root,arCOG02249@2157|Archaea,2XUZN@28890|Euryarchaeota,2NAC2@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
XH3_k127_4762990_5	593750.Metfor_0935	2.906e-36	139.0	COG1930@1|root,arCOG04384@2157|Archaea	2157|Archaea	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiN	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02007,ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiN
XH3_k127_4762990_4	593750.Metfor_0934	1.017e-37	143.0	COG0310@1|root,arCOG02248@2157|Archaea,2XU13@28890|Euryarchaeota,2N96W@224756|Methanomicrobia	224756|Methanomicrobia	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
XH3_k127_4763919_0	456442.Mboo_2075	7.158e-213	668.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N97Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
XH3_k127_4763919_3	410358.Mlab_0608	8.506e-56	200.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2N9GR@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
XH3_k127_4763919_1	456442.Mboo_2077	3.104e-190	600.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N918@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
XH3_k127_4763919_4	323259.Mhun_0792	2.005e-20	96.0	arCOG06905@1|root,arCOG06905@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4763919_2	593750.Metfor_0773	2.803e-77	269.0	COG2710@1|root,arCOG00593@2157|Archaea	2157|Archaea	C	PFAM oxidoreductase nitrogenase, component 1	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_nitro
XH3_k127_4786807_8	456442.Mboo_0733	3.729e-23	98.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,2N9FT@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
XH3_k127_4786807_4	368407.Memar_0846	3.896e-82	276.0	COG1838@1|root,arCOG04406@2157|Archaea,2XYBR@28890|Euryarchaeota,2NBIN@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, beta	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
XH3_k127_4786807_6	456442.Mboo_0731	2.311e-46	168.0	COG1146@1|root,arCOG00959@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	korD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
XH3_k127_4786807_0	593750.Metfor_2322	9.495e-174	550.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,2N9RY@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
XH3_k127_4786807_2	456442.Mboo_0729	8.82e-145	462.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2NBH3@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
XH3_k127_4786807_5	368407.Memar_0842	1.241e-79	269.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
XH3_k127_4786807_1	368407.Memar_0841	1.218e-156	501.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
XH3_k127_4786807_3	521011.Mpal_1945	7.695e-144	461.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
XH3_k127_4786807_7	456442.Mboo_1063	7.647e-27	115.0	COG0630@1|root,arCOG09437@2157|Archaea	2157|Archaea	NU	secretion by the type IV secretion system	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
XH3_k127_4813488_2	368407.Memar_0631	3.592e-105	349.0	COG2516@1|root,arCOG00662@2157|Archaea,2Y23P@28890|Euryarchaeota,2NBFM@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH3_k127_4813488_3	323259.Mhun_1802	8.988e-86	299.0	COG4231@1|root,arCOG01612@2157|Archaea,2XWAR@28890|Euryarchaeota,2N95R@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C,TPP_enzyme_N
XH3_k127_4813488_0	456442.Mboo_0598	2.244e-179	568.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,2N9F5@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
XH3_k127_4813488_1	456442.Mboo_0599	2.098e-111	367.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N92R@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC-2	-	4.2.1.114	ko:K16792	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
XH3_k127_4815771_2	368407.Memar_1849	8.948e-07	51.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
XH3_k127_4815771_0	456442.Mboo_2164	3.999e-257	801.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
XH3_k127_4815771_1	456442.Mboo_2163	5.733e-36	138.0	arCOG06510@1|root,arCOG06510@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
XH3_k127_4838200_2	323259.Mhun_0420	9.461e-96	336.0	COG3291@1|root,COG4870@1|root,arCOG03991@1|root,arCOG02510@2157|Archaea,arCOG03607@2157|Archaea,arCOG03991@2157|Archaea,arCOG05189@2157|Archaea,2XWQ1@28890|Euryarchaeota	28890|Euryarchaeota	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_C1
XH3_k127_4838200_1	456442.Mboo_1674	4.056e-159	506.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2N91S@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rad17,Rep_fac_C
XH3_k127_4838200_0	456442.Mboo_1673	6.722e-249	775.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,2N9E6@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
XH3_k127_4887348_0	593750.Metfor_1524	5.228e-302	934.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,2N9CQ@224756|Methanomicrobia	224756|Methanomicrobia	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
XH3_k127_4887348_2	593750.Metfor_1525	1.474e-24	109.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y17T@28890|Euryarchaeota,2NA3Y@224756|Methanomicrobia	224756|Methanomicrobia	S	RNase L inhibitor, RLI	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4887348_1	593750.Metfor_1526	4.97e-70	243.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,2N97T@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
XH3_k127_4894019_2	456442.Mboo_2106	4.741e-77	261.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,2N9EE@224756|Methanomicrobia	224756|Methanomicrobia	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
XH3_k127_4894019_1	368407.Memar_1904	9.016e-79	267.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,2N9N5@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
XH3_k127_4894019_3	368407.Memar_1903	4.357e-61	216.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,2N9V1@224756|Methanomicrobia	224756|Methanomicrobia	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
XH3_k127_4894019_0	593750.Metfor_0704	1.789e-80	273.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,2N91P@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
XH3_k127_4906245_3	368407.Memar_1784	7.697e-78	267.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
XH3_k127_4906245_5	521011.Mpal_0113	1.944e-40	157.0	COG1321@1|root,arCOG02099@2157|Archaea	2157|Archaea	K	iron dependent repressor	sirR	-	-	ko:K03709,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
XH3_k127_4906245_0	521011.Mpal_0112	3.081e-197	629.0	COG1796@1|root,arCOG00305@2157|Archaea,2XT14@28890|Euryarchaeota,2N90T@224756|Methanomicrobia	224756|Methanomicrobia	L	Helix-hairpin-helix domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8
XH3_k127_4906245_4	521011.Mpal_0111	8.441e-69	240.0	COG0020@1|root,arCOG01532@2157|Archaea,2XU1R@28890|Euryarchaeota,2N9SY@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Di-trans-poly-cis-decaprenylcistransferase	uppS-1	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
XH3_k127_4906245_2	456442.Mboo_2063	9.51e-98	325.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,2N9C9@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
XH3_k127_4906245_1	456442.Mboo_2062	4.256e-127	414.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,2N929@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
XH3_k127_4911376_2	368407.Memar_1240	9.21e-34	131.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,2N9EW@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM TatD-related deoxyribonuclease	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
XH3_k127_4911376_3	456442.Mboo_1670	9.619e-27	112.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,2N9YQ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
XH3_k127_4911376_0	323259.Mhun_0828	1.211e-98	337.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
XH3_k127_4911376_1	368407.Memar_1237	5.919e-56	203.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
XH3_k127_4932728_4	572547.Amico_1901	1.304e-05	49.0	COG1473@1|root,COG1473@2|Bacteria,3T9X3@508458|Synergistetes	508458|Synergistetes	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
XH3_k127_4932728_1	580340.Tlie_0306	8.322e-111	364.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,3TCII@508458|Synergistetes	508458|Synergistetes	H	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
XH3_k127_4932728_3	593750.Metfor_1449	2.673e-79	269.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,2N9QD@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM sugar isomerase (SIS)	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
XH3_k127_4932728_0	456442.Mboo_1200	7.067e-162	516.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9E9@224756|Methanomicrobia	224756|Methanomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
XH3_k127_4932728_2	456442.Mboo_1201	1.52e-90	301.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,2N94F@224756|Methanomicrobia	224756|Methanomicrobia	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
XH3_k127_4933680_1	323259.Mhun_2762	1.183e-90	318.0	COG3291@1|root,arCOG02510@2157|Archaea	2157|Archaea	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CHB_HEX_C_1,PKD
XH3_k127_4933680_0	456442.Mboo_1706	1.599e-167	538.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,2N94Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
XH3_k127_4933680_2	368407.Memar_0322	6.693e-50	184.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,2N9X8@224756|Methanomicrobia	224756|Methanomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
XH3_k127_4933680_3	593750.Metfor_1188	1.449e-24	106.0	COG0695@1|root,arCOG02607@2157|Archaea	2157|Archaea	O	COG3634 Alkyl hydroperoxide reductase, large subunit	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
XH3_k127_4933680_4	521011.Mpal_0009	5.376e-12	66.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
XH3_k127_4954_0	368407.Memar_1003	5.356e-109	357.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,2N91G@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
XH3_k127_4954_2	694440.JOMF01000005_gene204	1.297e-59	215.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,2N9PZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
XH3_k127_4954_3	456442.Mboo_0841	3.176e-49	181.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,2N9UY@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
XH3_k127_4954_4	679926.Mpet_0316	5.225e-41	160.0	COG2426@1|root,arCOG01330@2157|Archaea,2Y4KG@28890|Euryarchaeota	28890|Euryarchaeota	S	Small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
XH3_k127_4954_1	368407.Memar_1000	2.771e-68	238.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
XH3_k127_4967097_1	323259.Mhun_2931	3.501e-80	270.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2N9I9@224756|Methanomicrobia	28890|Euryarchaeota	E	PFAM ABC transporter related	yvrO-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
XH3_k127_4967097_0	521011.Mpal_1251	8.419e-142	460.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NA6W@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
XH3_k127_4967097_2	521011.Mpal_2412	5.571e-16	81.0	arCOG10151@1|root,arCOG10151@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3784
XH3_k127_4968422_0	593750.Metfor_2209	2.17e-77	268.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota	28890|Euryarchaeota	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
XH3_k127_4968422_4	1206741.BAFX01000075_gene3888	0.0001721	52.0	COG3247@1|root,COG3247@2|Bacteria,2H3AT@201174|Actinobacteria,4FZ1T@85025|Nocardiaceae	201174|Actinobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
XH3_k127_4968422_2	388399.SSE37_16538	1.696e-20	97.0	COG2862@1|root,COG2862@2|Bacteria,1PC4I@1224|Proteobacteria,2UFZB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein family, UPF0114	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
XH3_k127_4968422_3	679926.Mpet_0128	3.073e-15	86.0	arCOG11437@1|root,arCOG11437@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_4968422_1	368407.Memar_2408	5.866e-55	204.0	COG1575@1|root,arCOG00480@2157|Archaea,2XXM6@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
XH3_k127_5028884_2	593750.Metfor_2069	1.889e-37	144.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,2N91D@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent	dadD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
XH3_k127_5028884_1	368407.Memar_1088	1.827e-86	291.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,2NA1R@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
XH3_k127_5028884_0	456442.Mboo_0766	7.111e-155	498.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota,2NA3G@224756|Methanomicrobia	224756|Methanomicrobia	H	Nicotinic acid phosphoribosyltransferase	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
XH3_k127_5031885_0	368407.Memar_0854	8.777e-211	662.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,2N9BR@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
XH3_k127_5031885_2	368407.Memar_0853	1.101e-164	528.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2N97V@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
XH3_k127_5031885_1	456442.Mboo_0739	7.229e-183	584.0	COG0165@1|root,arCOG01748@2157|Archaea,2XUWS@28890|Euryarchaeota,2N9AC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
XH3_k127_5031885_7	593750.Metfor_2407	1.118e-78	265.0	COG4800@1|root,arCOG04375@2157|Archaea,2XXJS@28890|Euryarchaeota,2N9MB@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
XH3_k127_5031885_3	593750.Metfor_2406	2.129e-137	443.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV39@28890|Euryarchaeota,2N923@224756|Methanomicrobia	224756|Methanomicrobia	P	ABC transporter, substrate-binding protein, aliphatic	ssuA	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
XH3_k127_5031885_5	593750.Metfor_2405	6.225e-112	367.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,2N99H@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
XH3_k127_5031885_4	593750.Metfor_2404	7.637e-121	393.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
XH3_k127_5031885_6	456442.Mboo_0734	4.895e-85	284.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
XH3_k127_5031885_8	368407.Memar_0847	3.63e-19	90.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,2N9FT@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
XH3_k127_5084965_7	1041930.Mtc_2338	6.53e-21	94.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y4F6@28890|Euryarchaeota,2NB8I@224756|Methanomicrobia	224756|Methanomicrobia	C	ATP synthase subunit C	atpK-2	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
XH3_k127_5084965_6	1041930.Mtc_2337	7.773e-28	121.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y46J@28890|Euryarchaeota,2NB12@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE-2	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
XH3_k127_5084965_2	1041930.Mtc_2336	5.016e-114	378.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
XH3_k127_5084965_4	593750.Metfor_0257	1.047e-35	138.0	COG1436@1|root,arCOG04102@2157|Archaea,2XZ62@28890|Euryarchaeota,2NB4R@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF-2	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
XH3_k127_5084965_0	1041930.Mtc_2334	8.416e-300	927.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2NANC@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA-2	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
XH3_k127_5084965_1	304371.MCP_2291	1.549e-256	796.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2NAB4@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB-2	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
XH3_k127_5084965_3	1041930.Mtc_2332	2.502e-91	305.0	COG1394@1|root,arCOG04101@2157|Archaea,2Y394@28890|Euryarchaeota,2NA8W@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD-2	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
XH3_k127_5084965_5	1407650.BAUB01000007_gene1621	1.351e-30	124.0	COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H2N8@1129|Synechococcus	1117|Cyanobacteria	L	Endonuclease V	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
XH3_k127_5108027_7	521011.Mpal_2388	5.02e-62	217.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
XH3_k127_5108027_4	456442.Mboo_2224	5.064e-81	273.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,2N9QT@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
XH3_k127_5108027_5	593750.Metfor_0484	6.044e-72	244.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,2N9RP@224756|Methanomicrobia	224756|Methanomicrobia	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
XH3_k127_5108027_1	593750.Metfor_0485	1.889e-112	370.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
XH3_k127_5108027_9	456442.Mboo_2221	2.899e-48	176.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2N9UH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
XH3_k127_5108027_8	323259.Mhun_2897	3.111e-59	207.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,2N9Q5@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
XH3_k127_5108027_6	368407.Memar_1806	1.317e-63	220.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2N9S9@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
XH3_k127_5108027_10	323259.Mhun_2895	1.285e-31	125.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,2NA2D@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
XH3_k127_5108027_11	593750.Metfor_0491	7.57e-22	95.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,2NA2R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
XH3_k127_5108027_0	521011.Mpal_2379	1.103e-176	561.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,2NAG2@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
XH3_k127_5108027_2	521011.Mpal_2378	3.54e-104	341.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,2N9BZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
XH3_k127_5108027_3	593750.Metfor_0494	1.989e-97	323.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,2N9H3@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
XH3_k127_516140_0	593750.Metfor_2231	6.775e-145	464.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
XH3_k127_516140_1	593750.Metfor_2230	1.426e-52	189.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
XH3_k127_516140_2	456442.Mboo_0811	3.891e-42	156.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,2N9Y5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
XH3_k127_516140_3	323259.Mhun_1709	2.347e-27	115.0	COG1645@1|root,arCOG00578@2157|Archaea,2Y1BV@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
XH3_k127_516140_4	593750.Metfor_2220	5.576e-22	97.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
XH3_k127_517059_3	521011.Mpal_2020	7.658e-08	55.0	arCOG03732@1|root,arCOG03732@2157|Archaea	2157|Archaea	L	helicase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
XH3_k127_517059_0	593750.Metfor_2533	2.226e-188	594.0	COG1474@1|root,arCOG00467@2157|Archaea,2XTRB@28890|Euryarchaeota,2N9C7@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
XH3_k127_517059_1	456442.Mboo_0680	3.354e-176	555.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2N98S@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
XH3_k127_517059_2	368407.Memar_1026	3.575e-40	154.0	COG0500@1|root,arCOG04989@2157|Archaea,2Y0ZS@28890|Euryarchaeota,2N9SX@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
XH3_k127_5224531_2	1305735.JAFT01000005_gene3279	1.859e-12	76.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2U05J@28211|Alphaproteobacteria,2PFSU@252301|Oceanicola	28211|Alphaproteobacteria	KT	HD domain	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
XH3_k127_5224531_1	323259.Mhun_1474	9.181e-30	126.0	arCOG07674@1|root,arCOG07674@2157|Archaea,2Y48B@28890|Euryarchaeota,2NB17@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
XH3_k127_5224531_0	1122221.JHVI01000004_gene106	2.745e-191	606.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	yjgR	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853
XH3_k127_5307495_1	368407.Memar_1998	2.764e-108	359.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
XH3_k127_5307495_0	456442.Mboo_1901	7.765e-201	636.0	COG1492@1|root,arCOG00105@2157|Archaea,2XT04@28890|Euryarchaeota,2N93Y@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
XH3_k127_5307495_2	368407.Memar_1996	3.003e-21	97.0	arCOG07471@1|root,arCOG07471@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5307495_3	521011.Mpal_0985	1.452e-10	61.0	arCOG05314@1|root,arCOG05314@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5336785_2	693746.OBV_36450	1.225e-23	114.0	COG4908@1|root,COG4908@2|Bacteria,1TS0H@1239|Firmicutes,24B0M@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,DUF1298
XH3_k127_5336785_1	368407.Memar_1431	7.297e-43	165.0	COG0622@1|root,arCOG01141@2157|Archaea,2XX8V@28890|Euryarchaeota,2NB0G@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
XH3_k127_5336785_0	386456.JQKN01000004_gene154	1.325e-81	278.0	COG2006@1|root,arCOG02446@2157|Archaea,2XV9B@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
XH3_k127_5367300_0	323259.Mhun_2663	2.023e-211	670.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9W@28890|Euryarchaeota	28890|Euryarchaeota	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
XH3_k127_5374548_1	521011.Mpal_0487	1.557e-79	269.0	arCOG02976@1|root,arCOG02976@2157|Archaea,2XT7H@28890|Euryarchaeota,2N9TE@224756|Methanomicrobia	224756|Methanomicrobia	S	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5374548_2	368407.Memar_0756	2.462e-39	156.0	COG0314@1|root,arCOG00533@2157|Archaea,2XVFP@28890|Euryarchaeota,2N9H4@224756|Methanomicrobia	224756|Methanomicrobia	H	MoaE protein	mobB	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,MobB
XH3_k127_5374548_0	456442.Mboo_0714	1.155e-178	569.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
XH3_k127_5387192_4	456442.Mboo_1914	3.234e-16	83.0	arCOG09604@1|root,arCOG09604@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5387192_1	521011.Mpal_0687	3.637e-75	261.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,2N9XX@224756|Methanomicrobia	224756|Methanomicrobia	N	Peptidase A24A, prepilin type IV	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
XH3_k127_5387192_2	593750.Metfor_1060	9.868e-51	187.0	COG0139@1|root,arCOG02676@2157|Archaea,2XX3X@28890|Euryarchaeota,2N9QJ@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
XH3_k127_5387192_0	456442.Mboo_1923	7.899e-304	941.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2N924@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM PilT protein domain protein	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
XH3_k127_5387192_3	456442.Mboo_1924	5.198e-40	149.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
XH3_k127_5401922_2	521011.Mpal_1359	5.289e-09	66.0	arCOG09441@1|root,arCOG09441@2157|Archaea	521011.Mpal_1359|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5401922_3	1300345.LF41_717	4.051e-08	63.0	2AQ4A@1|root,31F9J@2|Bacteria,1QCQH@1224|Proteobacteria,1T8GE@1236|Gammaproteobacteria,1XAMR@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5401922_1	521011.Mpal_2430	2.453e-15	82.0	arCOG09489@1|root,arCOG09489@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5436218_1	323259.Mhun_1707	7.077e-241	752.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
XH3_k127_5436218_0	456442.Mboo_0813	3.163e-264	827.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
XH3_k127_5509804_1	323259.Mhun_1595	1.634e-22	103.0	arCOG03888@1|root,arCOG03888@2157|Archaea,2Y5UT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5509804_0	456442.Mboo_0695	3.051e-198	623.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,2NB7I@224756|Methanomicrobia	224756|Methanomicrobia	D	Involved in cell shape control	cetZ	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
XH3_k127_5509804_2	1048829.XP_002796014.1	0.0008684	44.0	COG2440@1|root,KOG2415@2759|Eukaryota,38H8R@33154|Opisthokonta,3NY0G@4751|Fungi,3QQD7@4890|Ascomycota,20AG9@147545|Eurotiomycetes,3AZ3R@33183|Onygenales,3FJKY@34383|Onygenales incertae sedis	4751|Fungi	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0006116,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019362,GO:0019637,GO:0019674,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0046483,GO:0046496,GO:0048037,GO:0048038,GO:0048039,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070013,GO:0071704,GO:0072524,GO:0098573,GO:0098798,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
XH3_k127_5510900_2	521011.Mpal_2014	6.96e-143	457.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,2N98Z@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA-1	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
XH3_k127_5510900_1	456442.Mboo_0672	3.927e-150	481.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2N989@224756|Methanomicrobia	224756|Methanomicrobia	C	thiamine pyrophosphate enzyme domain protein TPP-binding	porB-1	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
XH3_k127_5510900_3	593750.Metfor_2528	1.348e-41	161.0	arCOG02874@1|root,arCOG02874@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_5510900_0	593750.Metfor_2527	4.651e-171	540.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2N96D@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC-1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
XH3_k127_552411_1	679926.Mpet_2592	1.809e-117	384.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,2N92N@224756|Methanomicrobia	224756|Methanomicrobia	D	PFAM PP-loop domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
XH3_k127_552411_0	368407.Memar_0482	1.114e-117	384.0	COG0478@1|root,arCOG01181@2157|Archaea,2XUJ4@28890|Euryarchaeota,2N9I8@224756|Methanomicrobia	224756|Methanomicrobia	T	Rio2, N-terminal	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
XH3_k127_552411_2	456442.Mboo_2320	1.473e-28	119.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
XH3_k127_5579281_1	290317.Cpha266_2446	1.014e-07	55.0	COG1722@1|root,COG1722@2|Bacteria,1FEAV@1090|Chlorobi	1090|Chlorobi	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
XH3_k127_5579281_0	456442.Mboo_1893	1.235e-92	311.0	COG1570@1|root,arCOG04513@2157|Archaea,2XVDP@28890|Euryarchaeota,2NAAC@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM Exonuclease VII large subunit	-	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
XH3_k127_5734693_9	593750.Metfor_1674	1.103e-54	197.0	COG1282@1|root,arCOG09400@2157|Archaea,2XV3Y@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM NAD(P) transhydrogenase, beta subunit	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
XH3_k127_5734693_11	593750.Metfor_1673	2.248e-44	163.0	COG3288@1|root,arCOG09401@2157|Archaea,2XZE6@28890|Euryarchaeota	28890|Euryarchaeota	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
XH3_k127_5734693_3	593750.Metfor_1672	7.011e-186	587.0	COG0686@1|root,arCOG06678@2157|Archaea,2XZEG@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM alanine dehydrogenase PNT domain protein	-	GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1,1.6.1.2	ko:K00259,ko:K00324	ko00250,ko00430,ko00760,ko01100,map00250,map00430,map00760,map01100	-	R00112,R00396	RC00001,RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
XH3_k127_5734693_2	593750.Metfor_1671	2.507e-206	656.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
XH3_k127_5734693_0	456442.Mboo_1313	1.759e-211	668.0	COG0343@1|root,arCOG00989@2157|Archaea,2XTFH@28890|Euryarchaeota,2N9F2@224756|Methanomicrobia	224756|Methanomicrobia	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
XH3_k127_5734693_8	368407.Memar_1288	2.929e-68	241.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,2N9RQ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
XH3_k127_5734693_7	593750.Metfor_1608	6.324e-72	246.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,2N9J9@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3
XH3_k127_5734693_6	593750.Metfor_1606	3.606e-90	303.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,2N9G7@224756|Methanomicrobia	224756|Methanomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
XH3_k127_5734693_1	368407.Memar_1293	3.035e-211	686.0	COG0826@1|root,arCOG03203@2157|Archaea,2XT7F@28890|Euryarchaeota,2N97J@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
XH3_k127_5734693_10	521011.Mpal_2603	2.652e-53	195.0	COG0169@1|root,arCOG02097@2157|Archaea,2XWH4@28890|Euryarchaeota,2N9XM@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
XH3_k127_5734693_4	368407.Memar_1296	1.993e-150	484.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,2N90S@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
XH3_k127_5734693_5	368407.Memar_1297	3.004e-138	453.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,2N9IF@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,2.7.1.71,4.2.1.10	ko:K00014,ko:K00891,ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R02413,R03084	RC00002,RC00078,RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0923	SKI,Shikimate_DH,Shikimate_dh_N
XH3_k127_5734693_12	593750.Metfor_1594	1.251e-38	147.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,2N97U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
XH3_k127_5797833_0	368407.Memar_1933	5.183e-158	509.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,2N90R@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
XH3_k127_5797833_1	456442.Mboo_0275	1.644e-89	306.0	COG0572@1|root,arCOG05133@2157|Archaea,2XU2D@28890|Euryarchaeota	28890|Euryarchaeota	F	uridine kinase	udk	-	2.7.1.19,2.7.1.48	ko:K00855,ko:K00876	ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200	M00165,M00166	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
XH3_k127_5797833_2	456442.Mboo_2084	8.007e-22	100.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
XH3_k127_5919189_2	410358.Mlab_0978	3.042e-34	133.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,2N95Z@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
XH3_k127_5919189_1	456442.Mboo_1841	5.457e-89	301.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,2N9TJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
XH3_k127_5919189_0	456442.Mboo_1843	4.089e-90	306.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,2N9SR@224756|Methanomicrobia	224756|Methanomicrobia	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
XH3_k127_5933610_1	521011.Mpal_0221	1.422e-86	299.0	COG1361@1|root,arCOG02079@2157|Archaea,2XTCZ@28890|Euryarchaeota,2NBGV@224756|Methanomicrobia	28890|Euryarchaeota	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,NPCBM_assoc
XH3_k127_5933610_2	521011.Mpal_1202	1.336e-60	218.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,2N9ZM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
XH3_k127_5933610_0	456442.Mboo_2327	1.239e-99	332.0	COG1693@1|root,arCOG02711@2157|Archaea,2XUUJ@28890|Euryarchaeota,2N94A@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function DUF128	-	-	-	ko:K21640	-	-	-	-	ko00000	-	-	-	DUF128
XH3_k127_5967100_8	456442.Mboo_1175	2.557e-16	82.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,2NAVD@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
XH3_k127_5967100_3	309799.DICTH_0452	4.97e-70	243.0	COG2135@1|root,COG2135@2|Bacteria	2|Bacteria	S	peptidase activity	yoqW	-	-	-	-	-	-	-	-	-	-	-	SRAP
XH3_k127_5967100_6	521011.Mpal_2748	3.251e-39	149.0	arCOG03597@1|root,arCOG03597@2157|Archaea,2Y07Y@28890|Euryarchaeota,2NBAH@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
XH3_k127_5967100_4	593750.Metfor_0763	5.263e-66	230.0	COG4843@1|root,arCOG06902@2157|Archaea	2157|Archaea	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
XH3_k127_5967100_1	456442.Mboo_2090	3.63e-118	385.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,2N9NQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
XH3_k127_5967100_0	593750.Metfor_0760	9.344e-197	627.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
XH3_k127_5967100_7	456320.Mvol_0335	9.16e-17	83.0	COG4033@1|root,arCOG04844@2157|Archaea,2XYZ8@28890|Euryarchaeota,23R60@183939|Methanococci	183939|Methanococci	S	PFAM Uncharacterised conserved protein UCP006577	-	-	-	-	-	-	-	-	-	-	-	-	DUF1894
XH3_k127_5967100_5	593750.Metfor_0756	5.591e-56	199.0	COG4081@1|root,arCOG04845@2157|Archaea,2XXFT@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1890
XH3_k127_5967100_2	368407.Memar_1911	6.945e-72	250.0	COG1526@1|root,arCOG04358@2157|Archaea,2XY65@28890|Euryarchaeota,2NBJ5@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM formate dehydrogenase family accessory protein FdhD	-	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
XH3_k127_5967100_9	459495.SPLC1_S411040	6.418e-07	51.0	COG1324@1|root,COG1324@2|Bacteria,1G7PJ@1117|Cyanobacteria,1HCDQ@1150|Oscillatoriales	1117|Cyanobacteria	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
XH3_k127_5994130_4	593750.Metfor_0998	6.838e-28	117.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,2N9Z3@224756|Methanomicrobia	224756|Methanomicrobia	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
XH3_k127_5994130_3	456442.Mboo_1953	2.306e-52	185.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,2N9XH@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
XH3_k127_5994130_5	410358.Mlab_1300	3.186e-22	96.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
XH3_k127_5994130_1	323259.Mhun_1128	9.896e-113	368.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,2N93I@224756|Methanomicrobia	224756|Methanomicrobia	J	Translation initiation factor 2 alpha subunit	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
XH3_k127_5994130_6	273063.STK_09405	2.307e-14	75.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
XH3_k127_5994130_2	323259.Mhun_1126	3.228e-96	322.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2N9I4@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
XH3_k127_5994130_0	410358.Mlab_1296	1.418e-143	464.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,2N99G@224756|Methanomicrobia	224756|Methanomicrobia	S	PHP C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
XH3_k127_6001196_7	521011.Mpal_2235	1.432e-45	166.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	fwdB-1	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
XH3_k127_6001196_12	456442.Mboo_0876	5.131e-05	46.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,2N9G0@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase subunit A	fmdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
XH3_k127_6001196_11	679926.Mpet_1277	3.361e-17	83.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_24,HTH_27,HTH_5
XH3_k127_6001196_10	641491.DND132_1756	3.022e-17	81.0	COG1773@1|root,COG1773@2|Bacteria,1NES3@1224|Proteobacteria,42VN9@68525|delta/epsilon subdivisions,2WRT2@28221|Deltaproteobacteria,2MCJQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the rubredoxin family	-	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114	-	-	-	-	-	-	-	-	-	-	Rubredoxin
XH3_k127_6001196_4	456442.Mboo_1653	5.427e-91	308.0	COG1814@1|root,arCOG01096@2157|Archaea,2Y0T2@28890|Euryarchaeota	28890|Euryarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
XH3_k127_6001196_5	368407.Memar_0972	2.198e-77	267.0	COG1571@1|root,arCOG01116@2157|Archaea,2Y2R5@28890|Euryarchaeota,2NA6I@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogenesis marker protein 11	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
XH3_k127_6001196_0	593750.Metfor_1501	6.67e-146	469.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,2N91A@224756|Methanomicrobia	224756|Methanomicrobia	E	homoserine dehydrogenase	thrA	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
XH3_k127_6001196_6	593750.Metfor_1502	2.987e-65	229.0	COG2061@1|root,arCOG04396@2157|Archaea,2XWMD@28890|Euryarchaeota,2N9PF@224756|Methanomicrobia	224756|Methanomicrobia	E	amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6001196_8	1231241.Mc24_08439	3.467e-38	151.0	2ECM2@1|root,336J2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
XH3_k127_6001196_2	593750.Metfor_0764	4.926e-115	385.0	COG4637@1|root,arCOG03241@2157|Archaea	2157|Archaea	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
XH3_k127_6001196_1	368407.Memar_0659	9.254e-129	417.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N9HU@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
XH3_k127_6001196_3	368407.Memar_0658	3.093e-103	341.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
XH3_k127_6001196_9	123214.PERMA_0044	9.38e-35	138.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	glsA	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	CBS,Glutaminase,MS_channel,STAS,cNMP_binding
XH3_k127_6037341_2	368407.Memar_2448	1.291e-62	220.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
XH3_k127_6037341_5	593750.Metfor_2692	1.503e-31	126.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y1WV@28890|Euryarchaeota,2NA61@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
XH3_k127_6037341_6	521011.Mpal_2597	2.799e-28	115.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_24,HTH_27,HTH_5
XH3_k127_6037341_7	368407.Memar_2451	3.21e-24	106.0	arCOG03400@1|root,arCOG03400@2157|Archaea	2157|Archaea	F	nucleic acid binding OB-fold tRNA helicase-type	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-codon
XH3_k127_6037341_3	593750.Metfor_2689	2.326e-45	172.0	COG5635@1|root,arCOG02967@2157|Archaea	2157|Archaea	T	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
XH3_k127_6037341_1	593750.Metfor_2688	9.536e-93	312.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,2N950@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
XH3_k127_6037341_0	368407.Memar_0820	4.724e-119	389.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
XH3_k127_6037341_4	593750.Metfor_2687	3.77e-43	158.0	COG1712@1|root,arCOG00254@2157|Archaea,2XXKF@28890|Euryarchaeota,2N96R@224756|Methanomicrobia	224756|Methanomicrobia	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21,5.3.3.2	ko:K01823,ko:K06989	ko00760,ko00900,ko01100,ko01110,ko01130,map00760,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123,R07407,R07410	RC00455,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF108,NAD_binding_3
XH3_k127_6041369_2	593750.Metfor_1876	5.802e-44	162.0	COG4738@1|root,arCOG04377@2157|Archaea,2Y0VV@28890|Euryarchaeota,2N9YZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6041369_1	521011.Mpal_0583	1.7e-80	276.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
XH3_k127_6041369_0	521011.Mpal_0582	1.693e-86	289.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,2N9DM@224756|Methanomicrobia	224756|Methanomicrobia	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1192	SurE
XH3_k127_6070423_5	694440.JOMF01000008_gene953	2.328e-44	166.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
XH3_k127_6070423_1	593750.Metfor_1114	3.543e-89	297.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,2N9MM@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
XH3_k127_6070423_6	679926.Mpet_1858	3.264e-43	160.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
XH3_k127_6070423_4	521011.Mpal_0547	4.381e-48	173.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,2N9X1@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
XH3_k127_6070423_0	456442.Mboo_1875	4.491e-174	554.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
XH3_k127_6070423_2	679926.Mpet_1855	3.99e-71	245.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
XH3_k127_6070423_3	521011.Mpal_0544	6.915e-54	190.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,2N99J@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
XH3_k127_6077070_6	1122614.JHZF01000013_gene3462	1.09e-07	57.0	COG0385@1|root,COG0385@2|Bacteria	2|Bacteria	S	bile acid:sodium symporter activity	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
XH3_k127_6077070_1	368407.Memar_2438	1.175e-43	167.0	arCOG04662@1|root,arCOG04662@2157|Archaea,2XU93@28890|Euryarchaeota,2NBCG@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6077070_3	679926.Mpet_0355	6.265e-27	115.0	COG0640@1|root,arCOG01680@2157|Archaea,2Y05Q@28890|Euryarchaeota,2NA1B@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
XH3_k127_6077070_0	456442.Mboo_0218	6.198e-49	179.0	COG0394@1|root,arCOG04425@2157|Archaea,2XZ4R@28890|Euryarchaeota,2N9TH@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
XH3_k127_6077070_4	368407.Memar_1051	2.154e-22	102.0	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
XH3_k127_6077070_2	679926.Mpet_1563	1.118e-38	149.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0IM@28890|Euryarchaeota,2NBF7@224756|Methanomicrobia	224756|Methanomicrobia	O	Hydrogenase maturation protease	-	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
XH3_k127_6077070_5	323259.Mhun_2592	7.973e-08	53.0	COG1143@1|root,arCOG01543@2157|Archaea,2XYQV@28890|Euryarchaeota	28890|Euryarchaeota	C	Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I)	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
XH3_k127_6084213_3	456442.Mboo_2440	6.461e-105	344.0	COG4052@1|root,arCOG03226@2157|Archaea,2XTWG@28890|Euryarchaeota,2N9D6@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogenesis marker protein 7	-	-	-	-	-	-	-	-	-	-	-	-	MCR_C
XH3_k127_6084213_10	323259.Mhun_0823	2.417e-10	68.0	arCOG10172@1|root,arCOG10172@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6084213_7	521011.Mpal_0248	2.162e-59	212.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y12T@28890|Euryarchaeota,2N9VC@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM alkylhydroperoxidase like protein, AhpD family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
XH3_k127_6084213_0	368407.Memar_1858	9.916e-260	814.0	COG1032@1|root,arCOG04984@2157|Archaea,2XUS3@28890|Euryarchaeota,2N97H@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
XH3_k127_6084213_8	456442.Mboo_2445	1.218e-47	175.0	COG1661@1|root,arCOG04212@2157|Archaea,2XZVT@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
XH3_k127_6084213_1	368407.Memar_2464	1.805e-176	572.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,2NA0A@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
XH3_k127_6084213_5	593750.Metfor_0197	4.729e-84	283.0	COG1704@1|root,arCOG04574@2157|Archaea,2XX6E@28890|Euryarchaeota,2N9YK@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
XH3_k127_6084213_2	593750.Metfor_0196	8.536e-124	404.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,2N945@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM elongation factor Tu domain 2	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
XH3_k127_6084213_4	368407.Memar_2470	2.172e-102	342.0	COG5418@1|root,arCOG02433@2157|Archaea,2Y7HZ@28890|Euryarchaeota,2NA0T@224756|Methanomicrobia	224756|Methanomicrobia	S	nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
XH3_k127_6084213_6	521011.Mpal_2788	1.023e-71	244.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
XH3_k127_6084213_9	909663.KI867150_gene2397	1.375e-43	172.0	COG2199@1|root,COG5001@1|root,COG2199@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2MQF2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9,Response_reg
XH3_k127_6098871_1	521011.Mpal_0251	1.054e-102	338.0	COG1924@1|root,arCOG02679@2157|Archaea,2XU50@28890|Euryarchaeota,2N92J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
XH3_k127_6098871_2	521011.Mpal_0252	2.648e-70	241.0	COG4050@1|root,arCOG04903@2157|Archaea,2XY68@28890|Euryarchaeota,2N9PJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2112
XH3_k127_6098871_3	368407.Memar_2063	2.025e-62	217.0	COG4029@1|root,arCOG04901@2157|Archaea,2XZQS@28890|Euryarchaeota,2N9W1@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2102)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2102
XH3_k127_6098871_0	456442.Mboo_2435	6.528e-185	591.0	COG4070@1|root,arCOG04900@2157|Archaea,2XU32@28890|Euryarchaeota,2N90Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the UPF0288 family	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6098871_4	593750.Metfor_0215	4.834e-35	134.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
XH3_k127_6138022_0	456442.Mboo_0270	3.888e-196	615.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,2N9BK@224756|Methanomicrobia	224756|Methanomicrobia	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
XH3_k127_6138022_1	368407.Memar_2211	2.992e-57	203.0	COG0494@1|root,arCOG01073@2157|Archaea	2157|Archaea	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
XH3_k127_6138022_2	593750.Metfor_2837	3.873e-53	188.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,2N9IW@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
XH3_k127_618766_3	1137269.AZWL01000051_gene531	1.034e-17	86.0	2AHJK@1|root,317XA@2|Bacteria,2GZYC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_618766_0	456442.Mboo_1616	1.377e-121	410.0	COG1624@1|root,arCOG02329@1|root,arCOG02385@1|root,arCOG02329@2157|Archaea,arCOG02385@2157|Archaea,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota	28890|Euryarchaeota	T	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N,PK_C
XH3_k127_618766_2	593750.Metfor_1097	2.412e-21	96.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
XH3_k127_618766_1	1519464.HY22_10520	7.981e-31	124.0	COG0586@1|root,COG0586@2|Bacteria,1FE4G@1090|Chlorobi	1090|Chlorobi	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
XH3_k127_621129_0	368407.Memar_0999	3.753e-136	442.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,2N975@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the ATCase OTCase family	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
XH3_k127_621129_1	593750.Metfor_2117	1.258e-81	275.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
XH3_k127_6223752_0	593750.Metfor_2004	3.572e-135	443.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
XH3_k127_6291367_0	323259.Mhun_0597	1.449e-94	329.0	COG3291@1|root,arCOG02559@1|root,arCOG06792@1|root,arCOG02508@2157|Archaea,arCOG02559@2157|Archaea,arCOG06792@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
XH3_k127_6291367_2	456442.Mboo_1677	4.349e-40	158.0	COG3390@1|root,arCOG02258@2157|Archaea	2157|Archaea	S	protein conserved in archaea	rpap1	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	tRNA_anti-codon
XH3_k127_6291367_1	593750.Metfor_1356	1.126e-81	277.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
XH3_k127_6322333_1	323259.Mhun_2561	4.947e-131	425.0	COG0113@1|root,arCOG04300@2157|Archaea,2XSZ8@28890|Euryarchaeota,2N97S@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
XH3_k127_6322333_0	456442.Mboo_1238	3.507e-171	547.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,2N97X@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
XH3_k127_6322333_2	368407.Memar_0979	1.442e-64	227.0	COG1648@1|root,arCOG01044@2157|Archaea,2XWMY@28890|Euryarchaeota,2N9U9@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM siroheme synthase	cysG	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
XH3_k127_6322333_3	456442.Mboo_0340	1.818e-30	125.0	COG5015@1|root,arCOG00528@2157|Archaea	2157|Archaea	S	PFAM Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
XH3_k127_6336600_0	368407.Memar_2326	6.79e-163	524.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
XH3_k127_6336600_1	323259.Mhun_2876	3.444e-78	281.0	arCOG02343@1|root,arCOG06919@1|root,arCOG07605@1|root,arCOG02343@2157|Archaea,arCOG06919@2157|Archaea,arCOG07605@2157|Archaea,2XX6C@28890|Euryarchaeota,2NAQA@224756|Methanomicrobia	224756|Methanomicrobia	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
XH3_k127_6410722_2	368407.Memar_2497	1.655e-58	205.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,2N93N@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
XH3_k127_6410722_0	456442.Mboo_2455	6.735e-155	494.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,2N98T@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
XH3_k127_6410722_1	593750.Metfor_0184	5.188e-70	242.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
XH3_k127_6417194_1	456442.Mboo_0122	2.812e-176	564.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,2N95C@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
XH3_k127_6417194_7	593750.Metfor_0248	2.44e-35	141.0	arCOG12673@1|root,arCOG12673@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6417194_2	368407.Memar_2141	1.727e-147	480.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
XH3_k127_6417194_4	521011.Mpal_2578	1.919e-114	376.0	COG0391@1|root,arCOG04395@2157|Archaea,2XTPP@28890|Euryarchaeota,2N94E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
XH3_k127_6417194_9	456442.Mboo_1308	8.623e-13	76.0	arCOG03906@1|root,arCOG03906@2157|Archaea,2XUWK@28890|Euryarchaeota	28890|Euryarchaeota	DZ	Domain of unknown function (DUF3821)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3821
XH3_k127_6417194_8	391623.TERMP_00142	9.675e-23	106.0	COG1669@1|root,COG2361@1|root,arCOG01206@2157|Archaea,arCOG05024@2157|Archaea,2Y0GK@28890|Euryarchaeota,244JN@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86
XH3_k127_6417194_0	521011.Mpal_0276	2.786e-211	665.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2N94I@224756|Methanomicrobia	224756|Methanomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
XH3_k127_6417194_5	368407.Memar_2152	7.177e-100	334.0	COG0620@1|root,arCOG01876@2157|Archaea,2XUCW@28890|Euryarchaeota,2NAQD@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Methionine synthase, vitamin-B12 independent	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
XH3_k127_6417194_6	456442.Mboo_0101	4.014e-52	193.0	COG0467@1|root,arCOG01175@2157|Archaea,2Y7UD@28890|Euryarchaeota,2NBDD@224756|Methanomicrobia	224756|Methanomicrobia	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
XH3_k127_6417194_3	593750.Metfor_0225	1.023e-124	406.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N9CH@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
XH3_k127_643079_2	456442.Mboo_0516	2.133e-29	119.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,2N9S7@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
XH3_k127_643079_1	521011.Mpal_2744	2.26e-70	244.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,2N9QB@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
XH3_k127_643079_0	456442.Mboo_0521	1.624e-112	367.0	COG0207@1|root,arCOG03214@2157|Archaea,2XTCY@28890|Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
XH3_k127_64645_0	521011.Mpal_0290	4.316e-161	512.0	COG0016@1|root,arCOG00411@2157|Archaea,2XUJD@28890|Euryarchaeota,2N9CX@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys)	sepS	-	6.1.1.27	ko:K07587	ko00970,map00970	M00360	R08576	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
XH3_k127_64645_2	456442.Mboo_0207	9.446e-113	375.0	COG0475@1|root,arCOG01955@2157|Archaea,2XT4U@28890|Euryarchaeota	28890|Euryarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
XH3_k127_64645_3	456442.Mboo_0206	4.125e-69	239.0	COG0490@1|root,arCOG01970@2157|Archaea,2XWSV@28890|Euryarchaeota	28890|Euryarchaeota	P	regulatory, ligand-binding protein related to C-terminal domains of K channels	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
XH3_k127_64645_8	368407.Memar_0249	6.417e-12	70.0	arCOG04907@1|root,arCOG04907@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_64645_5	857293.CAAU_0099	1.383e-38	149.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,36I0G@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
XH3_k127_64645_1	368407.Memar_0350	7.461e-144	465.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,2NAB8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
XH3_k127_64645_7	56110.Oscil6304_0015	8.551e-26	118.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G20P@1117|Cyanobacteria,1HEJ9@1150|Oscillatoriales	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_1,TPR_8
XH3_k127_64645_4	593750.Metfor_0652	1.113e-58	207.0	COG1633@1|root,arCOG01102@2157|Archaea,2Y446@28890|Euryarchaeota,2NB0Q@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
XH3_k127_64645_6	679926.Mpet_2737	3.797e-28	117.0	COG2881@1|root,arCOG03630@2157|Archaea	2157|Archaea	S	PFAM Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
XH3_k127_6467946_2	521011.Mpal_2526	2.43e-64	221.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
XH3_k127_6467946_0	456442.Mboo_1821	1.266e-109	358.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
XH3_k127_6467946_3	368407.Memar_1676	2.403e-41	154.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,2N9ZP@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
XH3_k127_6467946_7	323259.Mhun_2285	6.902e-18	90.0	COG1996@1|root,arCOG04341@2157|Archaea,2XZUD@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
XH3_k127_6467946_5	679926.Mpet_0962	5.855e-21	98.0	COG2136@1|root,arCOG03247@2157|Archaea	2157|Archaea	AJ	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
XH3_k127_6467946_6	593750.Metfor_1164	5.004e-19	89.0	COG2892@1|root,arCOG04414@2157|Archaea	2157|Archaea	S	protein conserved in archaea	pcc1	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
XH3_k127_6467946_4	593750.Metfor_1165	6.101e-40	155.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,2N9TP@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
XH3_k127_6467946_1	456442.Mboo_1815	3.344e-79	268.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,2N9FJ@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
XH3_k127_6676915_1	456442.Mboo_0144	1.419e-160	508.0	COG1982@1|root,arCOG00092@2157|Archaea	2157|Archaea	E	PFAM Orn Lys Arg decarboxylase major region	-	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
XH3_k127_6676915_0	456442.Mboo_0145	4.011e-168	533.0	COG0531@1|root,arCOG00009@2157|Archaea,2XUU6@28890|Euryarchaeota,2NAJQ@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM amino acid permease-associated region	-	-	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
XH3_k127_6752320_0	368407.Memar_2274	6.21e-151	483.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota,2NANV@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
XH3_k127_6752320_2	456442.Mboo_0610	5.077e-69	242.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2NATM@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
XH3_k127_6752320_1	767817.Desgi_2411	1.282e-77	270.0	COG0491@1|root,COG0491@2|Bacteria,1V2XF@1239|Firmicutes,24JW4@186801|Clostridia	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
XH3_k127_6752320_3	593750.Metfor_0236	7.41e-29	121.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota,2NB98@224756|Methanomicrobia	224756|Methanomicrobia	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
XH3_k127_6809223_2	456442.Mboo_0639	7.846e-11	64.0	COG3741@1|root,arCOG08266@2157|Archaea	2157|Archaea	E	N-formylglutamate amidohydrolase	-	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
XH3_k127_6809223_0	593750.Metfor_1116	1.965e-109	365.0	arCOG06899@1|root,arCOG06899@2157|Archaea,2Y419@28890|Euryarchaeota	28890|Euryarchaeota	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
XH3_k127_6897548_1	694440.JOMF01000004_gene1356	7.597e-18	86.0	arCOG03197@1|root,arCOG03197@2157|Archaea,2XZKC@28890|Euryarchaeota,2N9ZV@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6897548_0	521011.Mpal_2692	6.256e-102	339.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
XH3_k127_6929952_0	456442.Mboo_0937	1.033e-130	423.0	COG0433@1|root,arCOG00280@2157|Archaea,2XZQZ@28890|Euryarchaeota,2NB38@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
XH3_k127_6929952_1	456442.Mboo_0939	1.099e-19	89.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,2NA3F@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
XH3_k127_6975938_0	593750.Metfor_2512	9.712e-161	508.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
XH3_k127_6975938_2	593750.Metfor_2513	2.556e-58	204.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,2N9T3@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
XH3_k127_6975938_1	368407.Memar_0728	1.397e-76	261.0	COG4745@1|root,arCOG00562@2157|Archaea,2XUNV@28890|Euryarchaeota,2NAWY@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
XH3_k127_6994820_0	368407.Memar_2441	1.445e-170	548.0	COG1502@1|root,arCOG02039@2157|Archaea,2Y1F1@28890|Euryarchaeota	28890|Euryarchaeota	I	PFAM phospholipase D Transphosphatidylase	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
XH3_k127_6994820_3	521011.Mpal_1819	7.836e-11	68.0	arCOG06127@1|root,arCOG06127@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
XH3_k127_6994820_2	593750.Metfor_2006	3.151e-59	208.0	COG1202@1|root,arCOG03143@2157|Archaea,2XWI3@28890|Euryarchaeota	28890|Euryarchaeota	S	COG1202 Superfamily II helicase, archaea-specific	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_6994820_1	456442.Mboo_1053	2.093e-77	264.0	COG4749@1|root,arCOG04411@2157|Archaea,2XT50@28890|Euryarchaeota,2N9VH@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2150)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2150
XH3_k127_7003868_2	593750.Metfor_0673	2.643e-21	96.0	COG2998@1|root,arCOG00229@2157|Archaea,2XUR9@28890|Euryarchaeota,2N9NW@224756|Methanomicrobia	224756|Methanomicrobia	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
XH3_k127_7003868_1	1220534.B655_2239	8.263e-76	261.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type tungstate transport system, periplasmic component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
XH3_k127_7003868_0	593750.Metfor_0675	2.714e-84	288.0	COG3585@1|root,COG3839@1|root,arCOG00175@2157|Archaea,arCOG00228@2157|Archaea,2Y7NF@28890|Euryarchaeota,2N9QM@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE
XH3_k127_7010592_3	694440.JOMF01000004_gene1108	1.301e-66	237.0	COG0561@1|root,arCOG01213@2157|Archaea,2XX94@28890|Euryarchaeota,2N9JY@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the dephosphorylation of 2-phosphoglycolate	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
XH3_k127_7010592_0	593750.Metfor_0752	2.464e-176	556.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
XH3_k127_7010592_2	456442.Mboo_2098	2.115e-116	391.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
XH3_k127_7010592_1	456442.Mboo_2097	1.338e-168	537.0	COG0019@1|root,arCOG02268@2157|Archaea,2XSY8@28890|Euryarchaeota,2N93Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
XH3_k127_7021873_1	593750.Metfor_2583	1.178e-129	422.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia	224756|Methanomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
XH3_k127_7021873_0	521011.Mpal_1258	1.986e-140	454.0	COG0842@1|root,arCOG01467@2157|Archaea,2Y87M@28890|Euryarchaeota,2NBP0@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
XH3_k127_7021873_2	877455.Metbo_0714	1.93e-121	404.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota	28890|Euryarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
XH3_k127_7021873_3	29581.BW37_05028	5.049e-08	61.0	COG3595@1|root,COG3595@2|Bacteria,1N8NB@1224|Proteobacteria,2W3BX@28216|Betaproteobacteria,47558@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
XH3_k127_7027853_0	456442.Mboo_1709	0.0	1251.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
XH3_k127_7027853_4	593750.Metfor_1186	2.106e-28	119.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7027853_3	521011.Mpal_2059	1.953e-62	220.0	COG1777@1|root,arCOG01684@2157|Archaea,2XUMR@28890|Euryarchaeota,2NA1M@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K07721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
XH3_k127_7027853_1	521011.Mpal_2060	2.752e-227	712.0	COG0516@1|root,arCOG00612@2157|Archaea,2XU40@28890|Euryarchaeota,2NAPF@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
XH3_k127_7027853_2	521011.Mpal_2061	2.866e-97	322.0	COG1891@1|root,arCOG04482@2157|Archaea,2XUBQ@28890|Euryarchaeota,2N952@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P)	mfnB	-	4.2.3.153	ko:K09733	ko00680,map00680	-	R10935	RC03315	ko00000,ko00001,ko01000	-	-	-	4HFCP_synth
XH3_k127_7027853_5	521011.Mpal_2062	7.431e-26	108.0	COG1411@1|root,arCOG00616@2157|Archaea,2XYJ0@28890|Euryarchaeota,2N9PP@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
XH3_k127_7043433_1	521460.Athe_2034	1.791e-271	840.0	COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia,42J79@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ferredoxin-dependent glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
XH3_k127_7043433_2	456442.Mboo_0796	2.594e-166	530.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,2N9AE@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
XH3_k127_7043433_4	593750.Metfor_1233	8.597e-71	243.0	COG1528@1|root,arCOG01095@2157|Archaea,2XXEN@28890|Euryarchaeota,2NB1Y@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferritin-like domain	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
XH3_k127_7043433_3	1121448.DGI_2613	8.183e-123	405.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,42YP5@68525|delta/epsilon subdivisions,2WU50@28221|Deltaproteobacteria,2M9MU@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7043433_6	593750.Metfor_1237	1.682e-21	94.0	COG3350@1|root,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
XH3_k127_7043433_0	456442.Mboo_0789	0.0	1061.0	COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
XH3_k127_7043433_5	395963.Bind_3454	6.687e-27	116.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,3NBDQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
XH3_k127_7066023_4	1197130.BAFM01000017_gene2645	8.992e-46	176.0	COG0385@1|root,arCOG02191@2157|Archaea,2XWY8@28890|Euryarchaeota,23WFA@183963|Halobacteria	183963|Halobacteria	S	Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
XH3_k127_7066023_1	794846.AJQU01000069_gene1764	1.903e-133	431.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,2TVMD@28211|Alphaproteobacteria,4BA59@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
XH3_k127_7066023_0	1121946.AUAX01000010_gene3765	8.535e-168	536.0	COG2235@1|root,COG2235@2|Bacteria,2GJTR@201174|Actinobacteria,4D9VS@85008|Micromonosporales	201174|Actinobacteria	E	Amidinotransferase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
XH3_k127_7066023_2	1210884.HG799469_gene14124	1.974e-117	384.0	COG2326@1|root,COG2326@2|Bacteria,2IYWN@203682|Planctomycetes	203682|Planctomycetes	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
XH3_k127_7066023_5	368407.Memar_0451	2.389e-36	146.0	COG2426@1|root,arCOG01330@2157|Archaea	2157|Archaea	S	small multi-drug export	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
XH3_k127_7066023_3	679926.Mpet_0275	4.885e-56	199.0	arCOG04662@1|root,arCOG04662@2157|Archaea,2XU93@28890|Euryarchaeota,2NBCG@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7089232_2	323259.Mhun_3231	5.346e-31	130.0	COG0785@1|root,arCOG02400@2157|Archaea,2Y0J2@28890|Euryarchaeota,2NBK2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM cytochrome c biogenesis protein, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
XH3_k127_7089232_0	323259.Mhun_3230	1.817e-138	445.0	COG0548@1|root,arCOG00862@2157|Archaea,2XTW9@28890|Euryarchaeota,2N912@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
XH3_k127_7089232_1	593750.Metfor_0083	5.698e-129	417.0	COG1364@1|root,arCOG04413@2157|Archaea,2XUG6@28890|Euryarchaeota,2N99N@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2003	ArgJ
XH3_k127_7100337_4	368407.Memar_2160	2.899e-92	307.0	COG0253@1|root,arCOG02255@2157|Archaea,2XUYX@28890|Euryarchaeota,2NAG6@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
XH3_k127_7100337_1	521011.Mpal_0258	7.177e-166	529.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
XH3_k127_7100337_2	456442.Mboo_2432	5.413e-124	407.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2N97Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
XH3_k127_7100337_3	593750.Metfor_0216	5.776e-114	386.0	COG4087@1|root,arCOG01579@2157|Archaea,2XXV0@28890|Euryarchaeota,2N9NS@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iAF692.Mbar_A0708	Hydrolase
XH3_k127_7100337_0	593750.Metfor_0215	1.647e-219	687.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
XH3_k127_7107312_2	521011.Mpal_1823	6.126e-86	286.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,2N9EN@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
XH3_k127_7107312_1	456442.Mboo_1093	8.399e-189	603.0	COG0322@1|root,arCOG04753@2157|Archaea,2XTH1@28890|Euryarchaeota,2N9EV@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
XH3_k127_7107312_0	521011.Mpal_1821	1.088e-314	974.0	COG0556@1|root,arCOG04748@2157|Archaea,2XTM8@28890|Euryarchaeota,2NAF4@224756|Methanomicrobia	224756|Methanomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
XH3_k127_7107312_3	880073.Calab_1754	9.709e-54	197.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria	2|Bacteria	M	PKD domain	-	-	3.2.1.4,3.4.21.66	ko:K01179,ko:K08651	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3
XH3_k127_7120010_4	456442.Mboo_0066	2.16e-40	150.0	COG0365@1|root,arCOG04201@2157|Archaea,2Y84I@28890|Euryarchaeota,2NA7J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
XH3_k127_7120010_0	593750.Metfor_0087	1.446e-201	635.0	COG0477@1|root,arCOG00147@2157|Archaea,2XTS8@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
XH3_k127_7120010_5	456442.Mboo_2204	4.128e-34	138.0	COG3663@1|root,arCOG04947@2157|Archaea,2Y0SJ@28890|Euryarchaeota,2NA1T@224756|Methanomicrobia	224756|Methanomicrobia	L	Uracil DNA glycosylase superfamily	-	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
XH3_k127_7120010_6	679926.Mpet_2820	1.389e-24	104.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
XH3_k127_7120010_7	456442.Mboo_2175	3.744e-12	74.0	arCOG03888@1|root,arCOG03888@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7120010_3	192952.MM_0232	2.981e-47	172.0	COG3324@1|root,arCOG04946@2157|Archaea,2Y3YR@28890|Euryarchaeota,2NB03@224756|Methanomicrobia	224756|Methanomicrobia	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
XH3_k127_7120010_2	368407.Memar_1442	7.584e-85	289.0	COG0655@1|root,arCOG02572@2157|Archaea,2Y8HP@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM NAD(P)H dehydrogenase (quinone)	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
XH3_k127_7120010_1	1041930.Mtc_1121	8.023e-87	289.0	arCOG10401@1|root,arCOG10401@2157|Archaea,2Y2EP@28890|Euryarchaeota,2NA7M@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7120010_8	456442.Mboo_0096	3.043e-06	49.0	arCOG01788@1|root,arCOG01788@2157|Archaea,2XXVU@28890|Euryarchaeota,2NAW7@224756|Methanomicrobia	224756|Methanomicrobia	Q	O-methyltransferase	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25
XH3_k127_7128146_5	679926.Mpet_0679	2.2e-21	96.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia	224756|Methanomicrobia	G	Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
XH3_k127_7128146_0	456442.Mboo_1629	9.489e-137	441.0	COG2899@1|root,arCOG05299@2157|Archaea,2Y4HF@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
XH3_k127_7128146_4	521011.Mpal_2117	1.133e-25	111.0	COG0607@1|root,arCOG02021@2157|Archaea,2XYA6@28890|Euryarchaeota	28890|Euryarchaeota	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
XH3_k127_7128146_2	1365176.N186_00760	5.61e-44	164.0	COG2033@1|root,arCOG02146@2157|Archaea,2XQNQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Desulfoferrodoxin ferrous iron-binding region	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
XH3_k127_7128146_1	521011.Mpal_0470	1.782e-71	245.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYGC@28890|Euryarchaeota,2NAUV@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
XH3_k127_7128146_3	456442.Mboo_0705	2.619e-27	119.0	COG5184@1|root,arCOG08219@2157|Archaea	2157|Archaea	DZ	Domain of unknown function (DUF3821)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3821,Lipase_GDSL_2
XH3_k127_7133669_1	368407.Memar_0223	1.533e-115	379.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,2N9C4@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
XH3_k127_7133669_0	456442.Mboo_0087	2.18e-212	668.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,2N91C@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
XH3_k127_7133669_2	521011.Mpal_0402	1.804e-10	61.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinate dehydrogenase fumarate reductase flavoprotein subunit	sdhA	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114	1.3.4.1,1.3.5.1,1.3.5.4	ko:K00239,ko:K18209	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376,M00620	R02164,R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
XH3_k127_7146992_1	593750.Metfor_0976	4.335e-83	298.0	COG0515@1|root,arCOG02550@1|root,arCOG02550@2157|Archaea,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
XH3_k127_7146992_0	368407.Memar_2327	4.516e-248	783.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,2N9F3@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM CoA-binding domain protein	acdAB	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
XH3_k127_7146992_2	456442.Mboo_2131	2.797e-55	207.0	arCOG04580@1|root,arCOG04580@2157|Archaea,2XUWY@28890|Euryarchaeota,2NA9J@224756|Methanomicrobia	224756|Methanomicrobia	Q	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
XH3_k127_7149075_2	1340493.JNIF01000003_gene3540	2.337e-08	61.0	2EAFX@1|root,334J9@2|Bacteria,3Y83F@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7149075_0	521011.Mpal_1199	3.506e-215	682.0	COG0557@1|root,arCOG04686@2157|Archaea,2XT2E@28890|Euryarchaeota,2NA9N@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
XH3_k127_7149075_1	593750.Metfor_1337	4.906e-22	97.0	COG1773@1|root,arCOG04391@2157|Archaea,2Y5RW@28890|Euryarchaeota,2NBCH@224756|Methanomicrobia	224756|Methanomicrobia	C	Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
XH3_k127_7200972_1	521011.Mpal_2546	5.492e-30	119.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,2N946@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
XH3_k127_7200972_0	679926.Mpet_0923	1.344e-137	446.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,2N97Q@224756|Methanomicrobia	224756|Methanomicrobia	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
XH3_k127_7234519_0	1125863.JAFN01000001_gene1321	2.454e-97	334.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
XH3_k127_7234519_1	368407.Memar_1427	2.86e-51	190.0	COG5623@1|root,arCOG04127@2157|Archaea,2XT4Z@28890|Euryarchaeota	28890|Euryarchaeota	A	Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA	-	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
XH3_k127_7257819_1	368407.Memar_0486	3.038e-55	198.0	COG1361@1|root,arCOG02086@2157|Archaea,2Y7NE@28890|Euryarchaeota,2NA14@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7257819_0	368407.Memar_0485	2.185e-80	276.0	COG2140@1|root,arCOG02602@2157|Archaea,2XWS8@28890|Euryarchaeota,2N9IM@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Glucose-6-phosphate isomerase	gpi	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
XH3_k127_7257819_2	273116.14325284	5.094e-17	83.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,241S8@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
XH3_k127_7268836_1	368407.Memar_0896	6.495e-111	362.0	COG4912@1|root,arCOG05122@2157|Archaea,2XWYV@28890|Euryarchaeota,2N9IE@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
XH3_k127_7268836_8	304371.MCP_1390	6.957e-16	84.0	arCOG13226@1|root,arCOG13226@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7268836_5	368407.Memar_2463	4.584e-30	136.0	COG3042@1|root,arCOG12676@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF333)	-	-	-	ko:K09712	-	-	-	-	ko00000	-	-	-	DUF333
XH3_k127_7268836_7	456442.Mboo_0798	2.619e-16	93.0	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
XH3_k127_7268836_3	269797.Mbar_A1478	1.98e-35	154.0	arCOG02527@1|root,arCOG03991@1|root,arCOG02527@2157|Archaea,arCOG03991@2157|Archaea,2XYVG@28890|Euryarchaeota	28890|Euryarchaeota	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
XH3_k127_7268836_10	749222.Nitsa_1475	8.603e-13	70.0	COG3360@1|root,COG3360@2|Bacteria	2|Bacteria	P	Dodecin	secE2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
XH3_k127_7268836_2	368407.Memar_1121	9e-64	226.0	arCOG03570@1|root,arCOG03570@2157|Archaea,2XXVH@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
XH3_k127_7268836_6	269797.Mbar_A3243	8.115e-21	94.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
XH3_k127_7268836_0	521011.Mpal_1181	2.895e-114	375.0	arCOG06923@1|root,arCOG06923@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
XH3_k127_7268836_4	335543.Sfum_0670	5.904e-34	149.0	COG4447@1|root,COG4447@2|Bacteria,1PFB5@1224|Proteobacteria,437G8@68525|delta/epsilon subdivisions,2X2NT@28221|Deltaproteobacteria,2MRPS@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7268836_11	547559.Nmag_4208	1.799e-05	57.0	arCOG03606@1|root,arCOG07560@1|root,arCOG03606@2157|Archaea,arCOG07560@2157|Archaea,2XVKF@28890|Euryarchaeota,23UGM@183963|Halobacteria	183963|Halobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
XH3_k127_7268836_9	998674.ATTE01000001_gene1891	1.51e-14	87.0	COG1345@1|root,COG5492@1|root,COG1345@2|Bacteria,COG5492@2|Bacteria,1R8Z4@1224|Proteobacteria,1S0IR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,REJ
XH3_k127_7349114_1	593750.Metfor_1643	1.921e-149	475.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,2N958@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
XH3_k127_7349114_2	521011.Mpal_0740	1.74e-90	304.0	COG1082@1|root,arCOG01895@2157|Archaea,2XV4X@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
XH3_k127_7349114_3	323259.Mhun_1922	6.612e-17	86.0	COG0457@1|root,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
XH3_k127_7349114_4	1232428.CAVO010000035_gene1427	1.692e-06	56.0	COG0457@1|root,COG0457@2|Bacteria,1UYKM@1239|Firmicutes,4H2XY@909932|Negativicutes	909932|Negativicutes	S	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase,TPR_16,TPR_2,TPR_8
XH3_k127_7349114_0	368407.Memar_1381	0.0	1057.0	COG0243@1|root,arCOG01491@2157|Archaea,2XT94@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing	narB	-	1.17.1.9,1.20.2.1,1.20.9.1,1.7.7.2	ko:K00123,ko:K00367,ko:K00372,ko:K08356	ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,map00630,map00680,map00910,map01100,map01120,map01200	M00531	R00519,R00791,R00798,R01106	RC02796,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.6	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
XH3_k127_7372159_0	593750.Metfor_0338	5.581e-234	738.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
XH3_k127_7372159_1	593750.Metfor_0339	1.513e-96	326.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,2N9G5@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
XH3_k127_7386873_0	593750.Metfor_0182	4.107e-270	844.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
XH3_k127_7386873_1	593750.Metfor_0183	1.221e-76	261.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,2N9JJ@224756|Methanomicrobia	224756|Methanomicrobia	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
XH3_k127_7386873_2	368407.Memar_2499	2.646e-48	176.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
XH3_k127_7408938_4	368407.Memar_1517	0.0003245	43.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
XH3_k127_7408938_1	456442.Mboo_1271	9.54e-80	272.0	COG0327@1|root,arCOG04454@2157|Archaea,2XT5G@28890|Euryarchaeota,2N9RT@224756|Methanomicrobia	224756|Methanomicrobia	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
XH3_k127_7408938_2	368407.Memar_1514	6.976e-33	130.0	COG5431@1|root,arCOG01121@2157|Archaea,2XY1I@28890|Euryarchaeota	28890|Euryarchaeota	S	zinc finger, SWIM	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
XH3_k127_7408938_0	456442.Mboo_1267	0.0	1404.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
XH3_k127_7408938_3	456442.Mboo_1266	6.263e-08	54.0	COG0640@1|root,arCOG01686@2157|Archaea,2XX9R@28890|Euryarchaeota,2N9WK@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
XH3_k127_7430419_5	521011.Mpal_2152	8.56e-11	62.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZTH@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
XH3_k127_7430419_2	456442.Mboo_1406	3.468e-107	357.0	COG0079@1|root,arCOG04273@2157|Archaea,2XV1E@28890|Euryarchaeota,2N9D3@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,zf-like
XH3_k127_7430419_3	368407.Memar_1446	1.303e-65	231.0	COG2266@1|root,arCOG01871@2157|Archaea,2XZP4@28890|Euryarchaeota,2N9T9@224756|Methanomicrobia	224756|Methanomicrobia	M	MobA-like NTP transferase domain	cobY	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
XH3_k127_7430419_0	521011.Mpal_2149	1.026e-197	627.0	COG1915@1|root,arCOG04422@2157|Archaea,2XTUK@28890|Euryarchaeota,2NAC6@224756|Methanomicrobia	224756|Methanomicrobia	S	LOR SDH bifunctional enzyme conserved	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
XH3_k127_7430419_1	593750.Metfor_1761	4.305e-127	414.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
XH3_k127_7430419_4	593750.Metfor_1760	9.776e-51	191.0	arCOG06913@1|root,arCOG06913@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7449550_0	521011.Mpal_0402	6.881e-235	736.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinate dehydrogenase fumarate reductase flavoprotein subunit	sdhA	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114	1.3.4.1,1.3.5.1,1.3.5.4	ko:K00239,ko:K18209	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376,M00620	R02164,R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
XH3_k127_7449550_1	456442.Mboo_0085	5.381e-233	730.0	COG0247@1|root,COG0479@1|root,arCOG00333@2157|Archaea,arCOG00963@2157|Archaea,2Y85M@28890|Euryarchaeota,2N9EY@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
XH3_k127_7449550_8	593750.Metfor_0521	4.293e-44	166.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y1MD@28890|Euryarchaeota,2NA64@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7449550_2	1209989.TepiRe1_0900	9.323e-162	521.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
XH3_k127_7449550_3	521011.Mpal_0406	1.428e-157	505.0	COG0492@1|root,arCOG01297@2157|Archaea,2Y84N@28890|Euryarchaeota,2N9Q1@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB-1	-	1.8.1.9	ko:K00384,ko:K03387	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
XH3_k127_7449550_6	456442.Mboo_0082	8.868e-62	218.0	COG1592@1|root,arCOG01097@2157|Archaea,2XXBF@28890|Euryarchaeota,2N9UW@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
XH3_k127_7449550_10	593750.Metfor_2884	1.262e-24	105.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
XH3_k127_7449550_4	456442.Mboo_0081	5.539e-82	278.0	COG2003@1|root,arCOG04919@2157|Archaea,2XY1U@28890|Euryarchaeota,2N9SM@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
XH3_k127_7449550_5	456442.Mboo_0080	8.786e-71	245.0	COG0655@1|root,arCOG02574@2157|Archaea	2157|Archaea	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
XH3_k127_7449550_9	593750.Metfor_0068	9.226e-34	130.0	arCOG06934@1|root,arCOG06934@2157|Archaea	2157|Archaea	S	Zinc-ribbon containing domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1451
XH3_k127_7449550_12	593750.Metfor_0069	4.415e-15	75.0	arCOG02147@1|root,arCOG02147@2157|Archaea	2157|Archaea	S	PFAM Desulfoferrodoxin Dfx domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Desulfoferrod_N
XH3_k127_7449550_7	456442.Mboo_0078	9.924e-51	181.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y09M@28890|Euryarchaeota,2NA2E@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Carboxymuconolactone decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
XH3_k127_7449550_11	521011.Mpal_0307	2.09e-19	87.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota,2N9HS@224756|Methanomicrobia	224756|Methanomicrobia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
XH3_k127_751445_25	521011.Mpal_2090	5.798e-54	194.0	COG0641@1|root,arCOG00945@2157|Archaea,2XV96@28890|Euryarchaeota,2NABU@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
XH3_k127_751445_9	368407.Memar_1433	2.438e-79	281.0	COG0589@1|root,arCOG00449@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Usp
XH3_k127_751445_35	593750.Metfor_0759	6.584e-15	81.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7N5@28890|Euryarchaeota,2NB3I@224756|Methanomicrobia	224756|Methanomicrobia	T	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
XH3_k127_751445_13	456442.Mboo_0562	1.059e-73	248.0	COG1773@1|root,arCOG04391@2157|Archaea,2Y080@28890|Euryarchaeota	28890|Euryarchaeota	C	Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
XH3_k127_751445_12	456442.Mboo_0428	1.954e-74	257.0	COG2041@1|root,arCOG00266@2157|Archaea,2Y690@28890|Euryarchaeota,2NAWR@224756|Methanomicrobia	224756|Methanomicrobia	S	Oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
XH3_k127_751445_1	192952.MM_0843	3.137e-217	682.0	COG1541@1|root,arCOG02622@2157|Archaea,2XVU6@28890|Euryarchaeota,2N93X@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
XH3_k127_751445_20	456442.Mboo_0561	6.264e-67	233.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota	28890|Euryarchaeota	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
XH3_k127_751445_8	593750.Metfor_2627	2.954e-106	353.0	COG4866@1|root,arCOG05191@2157|Archaea	2157|Archaea	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
XH3_k127_751445_28	456442.Mboo_0559	2.732e-44	165.0	COG0454@1|root,arCOG00839@2157|Archaea,2Y20T@28890|Euryarchaeota,2NB2F@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
XH3_k127_751445_24	456442.Mboo_0558	9.263e-62	219.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,2N9PR@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
XH3_k127_751445_21	521011.Mpal_0467	1.414e-64	226.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,2N9PG@224756|Methanomicrobia	224756|Methanomicrobia	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
XH3_k127_751445_10	593750.Metfor_2631	2.877e-78	267.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota	28890|Euryarchaeota	F	Belongs to the archaeal adenylate kinase family	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
XH3_k127_751445_0	456442.Mboo_0555	1.1e-253	790.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,2N9AJ@224756|Methanomicrobia	224756|Methanomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
XH3_k127_751445_26	679926.Mpet_2210	6.927e-54	192.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2N9U7@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
XH3_k127_751445_11	593750.Metfor_2634	4.112e-75	258.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2N9JA@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM ribosomal protein L30P	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
XH3_k127_751445_5	456442.Mboo_0552	4.593e-112	363.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,2N954@224756|Methanomicrobia	224756|Methanomicrobia	J	With S4 and S12 plays an important role in translational accuracy	rps5	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
XH3_k127_751445_14	521011.Mpal_0461	1.251e-73	251.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2N9SW@224756|Methanomicrobia	224756|Methanomicrobia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
XH3_k127_751445_22	521011.Mpal_0460	1.411e-63	220.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,2N9QQ@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
XH3_k127_751445_30	368407.Memar_0581	3.411e-41	155.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,2N9TN@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
XH3_k127_751445_16	456442.Mboo_0548	1.119e-69	241.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,2N9KP@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
XH3_k127_751445_23	593750.Metfor_2640	1.572e-62	216.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2N9Q6@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
XH3_k127_751445_33	456442.Mboo_0546	3.117e-25	105.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y04R@28890|Euryarchaeota,2NA3T@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
XH3_k127_751445_17	593750.Metfor_2642	2.879e-69	238.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,2N9KJ@224756|Methanomicrobia	224756|Methanomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
XH3_k127_751445_4	593750.Metfor_2643	5.545e-114	371.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,2N9HR@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,RS4NT,Ribosomal_S4e,S4
XH3_k127_751445_29	368407.Memar_0575	5.834e-42	156.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2N9XR@224756|Methanomicrobia	224756|Methanomicrobia	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
XH3_k127_751445_15	456442.Mboo_0542	8.407e-70	239.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,2N9SH@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
XH3_k127_751445_27	456442.Mboo_0541	1.284e-52	186.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
XH3_k127_751445_32	368407.Memar_0572	3.56e-26	110.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,2NA4I@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
XH3_k127_751445_34	593750.Metfor_2648	4.81e-24	102.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,2NA4R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
XH3_k127_751445_6	521011.Mpal_0448	1.075e-111	365.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,2N95N@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
XH3_k127_751445_19	368407.Memar_0569	2.266e-67	232.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,2N9UR@224756|Methanomicrobia	224756|Methanomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
XH3_k127_751445_18	521011.Mpal_0446	1.599e-67	231.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,2N9PW@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
XH3_k127_751445_3	456442.Mboo_0535	1e-129	416.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,2N99T@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
XH3_k127_751445_31	456442.Mboo_0534	8.876e-29	117.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,2N9ZC@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
XH3_k127_751445_7	593750.Metfor_2654	1.06e-109	359.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,2N9DG@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
XH3_k127_751445_2	456442.Mboo_0532	5.53e-148	472.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,2N98A@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
XH3_k127_7537577_0	368407.Memar_1632	1.603e-145	467.0	COG1625@1|root,arCOG00950@2157|Archaea,2XTIR@28890|Euryarchaeota,2N94K@224756|Methanomicrobia	224756|Methanomicrobia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
XH3_k127_7537577_2	368407.Memar_0430	6.069e-68	233.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,2N9S2@224756|Methanomicrobia	224756|Methanomicrobia	J	ribosomal protein S15	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
XH3_k127_7537577_1	456442.Mboo_2236	4.539e-74	255.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
XH3_k127_7607307_3	768679.TTX_1787	4.303e-14	83.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRM8@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
XH3_k127_7607307_1	456442.Mboo_0221	1.576e-37	147.0	COG3042@1|root,arCOG12676@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF333)	-	-	-	ko:K09712	-	-	-	-	ko00000	-	-	-	DUF333
XH3_k127_7607307_2	456442.Mboo_1651	1.968e-14	78.0	arCOG12701@1|root,arCOG12701@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7607307_4	593750.Metfor_0230	8.951e-14	78.0	arCOG07676@1|root,arCOG07676@2157|Archaea	593750.Metfor_0230|-	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7607307_0	679926.Mpet_0119	1.968e-65	228.0	COG0475@1|root,arCOG01953@2157|Archaea,2XV77@28890|Euryarchaeota,2NATR@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
XH3_k127_7612545_1	368407.Memar_1421	7.515e-94	311.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,2N9ME@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
XH3_k127_7612545_0	456442.Mboo_0815	5.109e-98	326.0	arCOG04725@1|root,arCOG04725@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GerE
XH3_k127_7612545_2	456442.Mboo_0814	2.166e-57	202.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
XH3_k127_7648996_2	368407.Memar_1443	9.024e-16	81.0	arCOG06913@1|root,arCOG06913@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7648996_0	679926.Mpet_0795	2.864e-99	333.0	COG1408@1|root,arCOG01156@2157|Archaea,2XYFR@28890|Euryarchaeota,2NBCE@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
XH3_k127_7648996_1	323259.Mhun_0326	2.769e-48	176.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota	2157|Archaea	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
XH3_k127_7670040_5	368407.Memar_1522	1.245e-18	86.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,2N9MS@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
XH3_k127_7670040_6	456442.Mboo_1276	3.523e-18	87.0	arCOG06936@1|root,arCOG06936@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7670040_4	368407.Memar_1520	1.916e-29	122.0	arCOG05311@1|root,arCOG05311@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7670040_1	593750.Metfor_2033	2.297e-76	265.0	COG2122@1|root,arCOG04376@2157|Archaea,2XV48@28890|Euryarchaeota,2N9HW@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0280 family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
XH3_k127_7670040_2	456442.Mboo_1212	2.16e-67	245.0	COG4186@1|root,arCOG01154@2157|Archaea,2XYK6@28890|Euryarchaeota,2NB5V@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7670040_3	593750.Metfor_2034	2.625e-50	183.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,2NA23@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
XH3_k127_7670040_0	456442.Mboo_1272	1.133e-251	783.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
XH3_k127_7670040_7	679926.Mpet_1602	5.622e-08	55.0	COG0327@1|root,arCOG04454@2157|Archaea,2XT5G@28890|Euryarchaeota,2N9RT@224756|Methanomicrobia	224756|Methanomicrobia	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
XH3_k127_7818093_3	323259.Mhun_0330	4.635e-95	322.0	COG0411@1|root,arCOG00925@2157|Archaea,2XU75@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	livG-6	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
XH3_k127_7818093_4	593750.Metfor_1701	7.774e-76	261.0	COG0410@1|root,arCOG00924@2157|Archaea,2XT1R@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type branched-chain amino acid transport systems ATPase component	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
XH3_k127_7818093_1	593750.Metfor_1700	2.023e-116	387.0	COG4177@1|root,arCOG01274@2157|Archaea,2XVR5@28890|Euryarchaeota	28890|Euryarchaeota	E	Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
XH3_k127_7818093_0	323259.Mhun_0327	8.422e-133	428.0	COG0559@1|root,arCOG01269@2157|Archaea	2157|Archaea	E	COG0559 Branched-chain amino acid ABC-type transport system, permease components	livH1	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2
XH3_k127_7818093_2	323259.Mhun_0326	5.246e-109	359.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota	2157|Archaea	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
XH3_k127_7969811_1	368407.Memar_1620	1.25e-53	192.0	arCOG05116@1|root,arCOG05116@2157|Archaea,2XX7X@28890|Euryarchaeota	28890|Euryarchaeota	J	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_7969811_0	456442.Mboo_0937	1.074e-134	437.0	COG0433@1|root,arCOG00280@2157|Archaea,2XZQZ@28890|Euryarchaeota,2NB38@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
XH3_k127_7988602_0	593750.Metfor_2678	2.246e-126	407.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,2N93H@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
XH3_k127_7988602_1	593750.Metfor_2677	9.116e-77	263.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,2N9JS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
XH3_k127_7988602_2	593750.Metfor_2676	1.041e-20	95.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
XH3_k127_8004627_4	521011.Mpal_1540	4.266e-15	77.0	COG1522@1|root,arCOG04153@2157|Archaea,2XX2W@28890|Euryarchaeota,2N9ZN@224756|Methanomicrobia	224756|Methanomicrobia	K	B-block binding subunit of TFIIIC	-	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC
XH3_k127_8004627_2	593750.Metfor_1616	2.599e-34	132.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0FB@28890|Euryarchaeota,2NA05@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM
XH3_k127_8004627_1	368407.Memar_1563	4.715e-203	635.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota	28890|Euryarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
XH3_k127_8004627_5	521011.Mpal_0800	3.292e-08	60.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	hsp20b	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
XH3_k127_8004627_0	410358.Mlab_1124	4.466e-301	942.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N91U@224756|Methanomicrobia	224756|Methanomicrobia	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
XH3_k127_8004627_3	368407.Memar_1560	3.569e-28	115.0	COG0212@1|root,arCOG00474@2157|Archaea	2157|Archaea	H	5-formyltetrahydrofolate cycloligase	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
XH3_k127_8020582_1	593750.Metfor_2548	8.353e-106	345.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,2N987@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1514	His_biosynth
XH3_k127_8020582_0	456442.Mboo_0660	3.164e-183	582.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,2N9AH@224756|Methanomicrobia	224756|Methanomicrobia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
XH3_k127_8020582_2	368407.Memar_0653	6.565e-85	291.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
XH3_k127_8020582_3	456442.Mboo_0663	1.959e-35	137.0	arCOG08221@1|root,arCOG08221@2157|Archaea,2Y1Z0@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8020582_4	456442.Mboo_0664	2.747e-16	84.0	arCOG09427@1|root,arCOG09427@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8030599_1	1037409.BJ6T_58620	2.049e-07	61.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,3JUX4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
XH3_k127_8030599_0	521011.Mpal_0808	4.242e-31	125.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota,2N9QI@224756|Methanomicrobia	224756|Methanomicrobia	D	AAA domain	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	AAA_31,CbiA
XH3_k127_806978_0	593750.Metfor_1357	0.0	1005.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
XH3_k127_8168825_3	456442.Mboo_1634	1.956e-63	219.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,2N9BE@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
XH3_k127_8168825_4	368407.Memar_1406	9.613e-41	154.0	arCOG06906@1|root,arCOG06906@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8168825_1	593750.Metfor_2235	2.809e-102	340.0	COG0619@1|root,arCOG02250@2157|Archaea,2XXKA@28890|Euryarchaeota,2NAU8@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
XH3_k127_8168825_0	593750.Metfor_2236	1.031e-129	419.0	COG1122@1|root,arCOG00203@2157|Archaea,2Y7N4@28890|Euryarchaeota,2NBNB@224756|Methanomicrobia	224756|Methanomicrobia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
XH3_k127_8168825_5	368407.Memar_1403	2.614e-18	96.0	COG0310@1|root,arCOG03159@2157|Archaea,2Y22Y@28890|Euryarchaeota,2NBBK@224756|Methanomicrobia	224756|Methanomicrobia	P	PDGLE domain	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	PDGLE
XH3_k127_8168825_2	368407.Memar_1402	4.739e-80	278.0	COG0310@1|root,arCOG02248@2157|Archaea,2XU97@28890|Euryarchaeota,2NAT4@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
XH3_k127_8194376_3	593750.Metfor_2108	3.061e-35	136.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota,2NB58@224756|Methanomicrobia	224756|Methanomicrobia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
XH3_k127_8194376_2	593750.Metfor_2107	5.053e-64	224.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota,2NAWN@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
XH3_k127_8194376_4	521011.Mpal_0503	2.824e-34	135.0	arCOG05298@1|root,arCOG05298@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8194376_0	593750.Metfor_1895	1.645e-81	274.0	COG0288@1|root,arCOG02860@2157|Archaea,2XUWI@28890|Euryarchaeota,2NB9R@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
XH3_k127_8194376_1	456442.Mboo_1683	2.201e-65	233.0	COG3503@1|root,arCOG04370@2157|Archaea,2XWYK@28890|Euryarchaeota,2N9R6@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
XH3_k127_8194376_5	456442.Mboo_1575	9.721e-12	65.0	COG1001@1|root,arCOG00693@2157|Archaea,2XV8C@28890|Euryarchaeota,2NACW@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
XH3_k127_8279695_0	368407.Memar_1516	6.525e-66	239.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
XH3_k127_8279695_1	593750.Metfor_2580	1.325e-48	179.0	arCOG05293@1|root,arCOG05293@2157|Archaea	2157|Archaea	G	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
XH3_k127_8294403_5	456442.Mboo_0684	7.896e-56	200.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,2NA3A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
XH3_k127_8294403_2	521011.Mpal_1556	2.842e-76	261.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,2N9VP@224756|Methanomicrobia	224756|Methanomicrobia	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
XH3_k127_8294403_3	368407.Memar_0718	4.591e-66	228.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2N9MF@224756|Methanomicrobia	224756|Methanomicrobia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iAF692.Mbar_A3385	NDK
XH3_k127_8294403_7	521011.Mpal_0525	7.774e-30	119.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,2NA03@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
XH3_k127_8294403_6	521011.Mpal_0524	2.887e-35	134.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,2N9ZH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
XH3_k127_8294403_4	593750.Metfor_2521	6.733e-57	199.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2N9WX@224756|Methanomicrobia	224756|Methanomicrobia	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
XH3_k127_8294403_0	456442.Mboo_0691	1.496e-220	704.0	COG5427@1|root,arCOG00563@2157|Archaea,2XV1K@28890|Euryarchaeota,2NAMT@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
XH3_k127_8294403_1	593750.Metfor_2519	1.737e-94	316.0	COG0392@1|root,arCOG00897@2157|Archaea,2XT65@28890|Euryarchaeota,2NBAD@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
XH3_k127_8320957_3	368407.Memar_1386	2.326e-30	122.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
XH3_k127_8320957_1	593750.Metfor_1876	1.022e-46	171.0	COG4738@1|root,arCOG04377@2157|Archaea,2Y0VV@28890|Euryarchaeota,2N9YZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8320957_0	593750.Metfor_1875	2.02e-102	335.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbpE	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
XH3_k127_8320957_2	1220534.B655_1884	3.076e-38	148.0	COG2303@1|root,arCOG02232@2157|Archaea,2Y89C@28890|Euryarchaeota,23NTI@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Glucose-methanol-choline oxidoreductase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,GMC_oxred_C,GMC_oxred_N
XH3_k127_8334808_3	593750.Metfor_2137	5.876e-83	279.0	COG0550@1|root,arCOG00416@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,2N96B@224756|Methanomicrobia	224756|Methanomicrobia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
XH3_k127_8334808_0	521011.Mpal_1298	2.166e-209	662.0	COG0064@1|root,arCOG01718@2157|Archaea,2XSV3@28890|Euryarchaeota,2N981@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
XH3_k127_8334808_1	368407.Memar_0772	4.604e-204	642.0	COG0154@1|root,arCOG01717@2157|Archaea,2XTV3@28890|Euryarchaeota,2N94U@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
XH3_k127_8334808_4	456442.Mboo_0856	1.442e-27	114.0	COG0721@1|root,arCOG02726@2157|Archaea,2XYQ0@28890|Euryarchaeota,2N9Z4@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
XH3_k127_8334808_2	456442.Mboo_0855	2.22e-112	371.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,2N9WJ@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM asparagine synthase	asnB-2	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
XH3_k127_8334808_5	521011.Mpal_1453	1.103e-18	95.0	COG1940@1|root,arCOG04280@2157|Archaea,2XUQY@28890|Euryarchaeota	28890|Euryarchaeota	K	COG1940 Transcriptional regulator sugar kinase	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
XH3_k127_8341236_2	593750.Metfor_2057	1.491e-46	168.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
XH3_k127_8341236_1	323259.Mhun_0629	2.049e-86	295.0	COG0655@1|root,arCOG02578@2157|Archaea	2157|Archaea	P	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
XH3_k127_8341236_0	521011.Mpal_1626	4.988e-148	482.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,2N9P9@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
XH3_k127_8374762_2	1365176.N186_09050	4.474e-13	75.0	arCOG06589@1|root,arCOG06589@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K16923	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28	-	-	ECF-ribofla_trS,ECF_trnsprt
XH3_k127_8374762_0	456442.Mboo_0014	4.48e-71	247.0	COG1853@1|root,arCOG02016@2157|Archaea,2XYAJ@28890|Euryarchaeota,2N9RF@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
XH3_k127_8374762_1	456442.Mboo_0653	9.467e-43	170.0	arCOG11546@1|root,arCOG11546@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8374762_3	309799.DICTH_1706	1.514e-12	79.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,CBM9_1,PEGA,Peptidase_S9
XH3_k127_8421857_3	521011.Mpal_0697	2.386e-39	154.0	arCOG04006@1|root,arCOG04006@2157|Archaea	2157|Archaea	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
XH3_k127_8421857_0	593750.Metfor_1266	0.0	1030.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,2N99D@224756|Methanomicrobia	224756|Methanomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
XH3_k127_8421857_2	593750.Metfor_1265	4.331e-65	237.0	arCOG05312@1|root,arCOG05312@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8421857_1	593750.Metfor_1262	2.162e-75	258.0	COG2404@1|root,arCOG00423@2157|Archaea	2157|Archaea	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	DHHA1
XH3_k127_8454549_0	368407.Memar_1333	2.566e-176	560.0	COG1944@1|root,arCOG02882@2157|Archaea,2XUE0@28890|Euryarchaeota,2N9AP@224756|Methanomicrobia	224756|Methanomicrobia	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
XH3_k127_8454549_1	456442.Mboo_1942	8.148e-159	511.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,2N9D0@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
XH3_k127_8454549_2	456442.Mboo_1943	2.033e-69	246.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,2N9PE@224756|Methanomicrobia	224756|Methanomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
XH3_k127_8454549_3	456442.Mboo_1944	3.93e-32	126.0	COG0569@1|root,arCOG01957@2157|Archaea,2XUZB@28890|Euryarchaeota,2NA24@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
XH3_k127_8519806_5	593750.Metfor_2681	3.625e-07	52.0	COG1321@1|root,arCOG02100@2157|Archaea,2XXXA@28890|Euryarchaeota,2N9RI@224756|Methanomicrobia	224756|Methanomicrobia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
XH3_k127_8519806_4	679926.Mpet_2156	4.215e-62	224.0	COG0803@1|root,arCOG01005@2157|Archaea,2XV9U@28890|Euryarchaeota,2N9H1@224756|Methanomicrobia	224756|Methanomicrobia	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
XH3_k127_8519806_1	368407.Memar_0815	5.541e-91	306.0	COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota,2N9G8@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
XH3_k127_8519806_3	368407.Memar_0814	3.821e-84	288.0	COG1108@1|root,arCOG01006@2157|Archaea,2XTNB@28890|Euryarchaeota,2N9BQ@224756|Methanomicrobia	224756|Methanomicrobia	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	iAF692.Mbar_A0996	ABC-3
XH3_k127_8519806_2	368407.Memar_1200	4.732e-88	303.0	COG0477@1|root,arCOG00130@2157|Archaea,2XZC7@28890|Euryarchaeota,2N9WS@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
XH3_k127_8519806_0	456442.Mboo_1385	1.157e-248	769.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,2N99U@224756|Methanomicrobia	224756|Methanomicrobia	S	KH, type 1, domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
XH3_k127_8631298_1	679926.Mpet_0316	9.351e-44	165.0	COG2426@1|root,arCOG01330@2157|Archaea,2Y4KG@28890|Euryarchaeota	28890|Euryarchaeota	S	Small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
XH3_k127_8631298_2	679926.Mpet_2774	2.731e-11	70.0	arCOG03788@1|root,arCOG03788@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
XH3_k127_8631298_0	368407.Memar_2419	2.194e-45	168.0	COG0382@1|root,arCOG00483@2157|Archaea,2Y30Y@28890|Euryarchaeota,2NAFV@224756|Methanomicrobia	224756|Methanomicrobia	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
XH3_k127_8648307_1	368407.Memar_2171	9.445e-28	119.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,2NBE1@224756|Methanomicrobia	224756|Methanomicrobia	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4
XH3_k127_8648307_0	456442.Mboo_1366	3.329e-42	168.0	COG0628@1|root,arCOG02642@2157|Archaea,2XUF2@28890|Euryarchaeota,2NBJJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
XH3_k127_8678922_0	593750.Metfor_1653	3.731e-296	913.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,2N91T@224756|Methanomicrobia	224756|Methanomicrobia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
XH3_k127_8678922_1	368407.Memar_1062	1.496e-55	199.0	COG0576@1|root,arCOG04772@2157|Archaea,2XUCA@28890|Euryarchaeota,2NA0X@224756|Methanomicrobia	224756|Methanomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
XH3_k127_8678922_2	410358.Mlab_1122	7.144e-14	72.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2NAI4@224756|Methanomicrobia	224756|Methanomicrobia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,PAPS_reduct
XH3_k127_8679868_2	593750.Metfor_0998	1.785e-51	190.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,2N9Z3@224756|Methanomicrobia	224756|Methanomicrobia	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
XH3_k127_8679868_0	456442.Mboo_1955	2.534e-140	455.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
XH3_k127_8679868_1	456442.Mboo_1956	1.092e-72	249.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,2N9D5@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM histone acetyltransferase, ELP3 family	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
XH3_k127_8681997_4	679926.Mpet_1865	1.215e-67	234.0	COG0249@1|root,arCOG02897@2157|Archaea,2XT0M@28890|Euryarchaeota,2N9EU@224756|Methanomicrobia	224756|Methanomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
XH3_k127_8681997_0	593750.Metfor_1468	1.654e-164	536.0	COG0323@1|root,arCOG01166@2157|Archaea,2XTK1@28890|Euryarchaeota,2N9DA@224756|Methanomicrobia	224756|Methanomicrobia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
XH3_k127_8681997_1	56780.SYN_00402	1.108e-155	505.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2MQYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
XH3_k127_8681997_3	368407.Memar_1721	3.31e-90	305.0	COG1194@1|root,arCOG00462@2157|Archaea,2XSU9@28890|Euryarchaeota,2NBC3@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM HhH-GPD family protein	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
XH3_k127_8681997_5	456442.Mboo_1223	2.425e-57	206.0	COG2241@1|root,arCOG00650@2157|Archaea,2XZ22@28890|Euryarchaeota,2N9VQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit	cbiE	-	2.1.1.289	ko:K03399	ko00860,ko01100,map00860,map01100	-	R05813,R07775	RC00003,RC02052,RC02053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1492	TP_methylase
XH3_k127_8681997_2	593750.Metfor_1473	9.243e-113	373.0	COG1903@1|root,arCOG04383@2157|Archaea,2XV53@28890|Euryarchaeota,2N9AY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
XH3_k127_8701195_3	368407.Memar_1844	1.456e-22	104.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8ES@28890|Euryarchaeota,2NAX7@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
XH3_k127_8701195_1	593750.Metfor_0584	1.939e-66	232.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,2N9NN@224756|Methanomicrobia	224756|Methanomicrobia	Q	methyltransferase small	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
XH3_k127_8701195_0	368407.Memar_1846	5.914e-135	436.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
XH3_k127_8701195_2	456442.Mboo_2167	5.649e-48	174.0	COG0503@1|root,arCOG00030@2157|Archaea,2XTWM@28890|Euryarchaeota,2N9KI@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis	hpt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	iAF692.Mbar_A1633	Pribosyltran
XH3_k127_8800920_1	335543.Sfum_2040	1.792e-54	197.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria,2MR1K@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
XH3_k127_8800920_0	521011.Mpal_2559	1.56e-140	448.0	COG0466@1|root,arCOG02161@2157|Archaea,2XVXA@28890|Euryarchaeota,2N991@224756|Methanomicrobia	224756|Methanomicrobia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
XH3_k127_8846167_3	456442.Mboo_1176	1.516e-94	312.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
XH3_k127_8846167_1	368407.Memar_0989	2.159e-165	527.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,2N9D1@224756|Methanomicrobia	224756|Methanomicrobia	E	Carbamoyl-phosphate synthase, small chain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
XH3_k127_8846167_0	593750.Metfor_2111	0.0	1713.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,2N92M@224756|Methanomicrobia	224756|Methanomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2374	CPSase_L_D2,CPSase_L_D3,MGS
XH3_k127_8846167_2	593750.Metfor_2113	3.263e-101	331.0	COG0137@1|root,arCOG00112@2157|Archaea,2XU8K@28890|Euryarchaeota,2N9DR@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
XH3_k127_8891682_7	593750.Metfor_2113	2.944e-36	138.0	COG0137@1|root,arCOG00112@2157|Archaea,2XU8K@28890|Euryarchaeota,2N9DR@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
XH3_k127_8891682_6	368407.Memar_1441	4.953e-47	172.0	COG3576@1|root,arCOG00518@2157|Archaea,2XYMW@28890|Euryarchaeota,2N9U6@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
XH3_k127_8891682_1	368407.Memar_1667	1.061e-114	380.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,2N9U1@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S protein PflX, homolog of pyruvate formate lyase activating	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
XH3_k127_8891682_5	456442.Mboo_0605	1.446e-60	214.0	COG4843@1|root,arCOG06902@2157|Archaea	2157|Archaea	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
XH3_k127_8891682_0	456442.Mboo_0618	1.178e-120	397.0	arCOG07502@1|root,arCOG07502@2157|Archaea,2Y56F@28890|Euryarchaeota,2NBE8@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8891682_4	368407.Memar_2380	4.861e-77	268.0	COG1408@1|root,arCOG01156@2157|Archaea,2XYFR@28890|Euryarchaeota,2NBCE@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
XH3_k127_8891682_2	593750.Metfor_2574	7.483e-93	308.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,2N9NF@224756|Methanomicrobia	224756|Methanomicrobia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
XH3_k127_8891682_8	368407.Memar_0906	1.794e-27	113.0	arCOG09491@1|root,arCOG09491@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8891682_9	1173263.Syn7502_00171	1.765e-25	109.0	2ECQX@1|root,336NM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8891682_12	456442.Mboo_0231	1.968e-17	84.0	arCOG09438@1|root,arCOG09438@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8891682_10	323259.Mhun_0919	2.176e-25	106.0	COG2036@1|root,arCOG02144@2157|Archaea	2157|Archaea	K	transcription factor (CBF NF-Y)	hstA	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
XH3_k127_8891682_11	1229909.NSED_02965	8.595e-18	85.0	arCOG07473@1|root,arCOG07473@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_8891682_3	368407.Memar_0491	2.878e-86	291.0	COG1227@1|root,arCOG01567@2157|Archaea,2XVM8@28890|Euryarchaeota	28890|Euryarchaeota	C	inorganic	ppaC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
XH3_k127_8909715_0	593750.Metfor_0224	7.374e-128	419.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,2N9FA@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
XH3_k127_8909715_1	456442.Mboo_2429	1.04e-33	132.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
XH3_k127_8988823_3	593750.Metfor_2499	1.258e-53	194.0	COG1518@1|root,arCOG01452@2157|Archaea	2157|Archaea	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas1
XH3_k127_8988823_1	593750.Metfor_2500	1.8e-224	700.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N9EC@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
XH3_k127_8988823_0	593750.Metfor_2501	1.309e-233	729.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N95A@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
XH3_k127_8988823_2	593750.Metfor_2502	5.75e-62	217.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota,2N9SE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
XH3_k127_9047418_2	456442.Mboo_0701	5.864e-41	154.0	COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,2N9QS@224756|Methanomicrobia	224756|Methanomicrobia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
XH3_k127_9047418_0	593750.Metfor_0687	3.004e-115	378.0	COG2221@1|root,arCOG02059@2157|Archaea	2157|Archaea	C	Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
XH3_k127_9047418_3	368407.Memar_0731	3.009e-24	107.0	arCOG05304@1|root,arCOG05304@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_9047418_1	593750.Metfor_2512	2.99e-114	370.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
XH3_k127_9108217_4	368407.Memar_1470	6.154e-18	89.0	arCOG08058@1|root,arCOG08058@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_9108217_2	593750.Metfor_2159	5.293e-78	268.0	COG0746@1|root,arCOG01872@2157|Archaea,2XWJR@28890|Euryarchaeota,2N9W7@224756|Methanomicrobia	224756|Methanomicrobia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
XH3_k127_9108217_3	323259.Mhun_0964	1.855e-40	154.0	COG0350@1|root,arCOG02724@2157|Archaea,2XZSR@28890|Euryarchaeota,2N9ZT@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
XH3_k127_9108217_0	593750.Metfor_2157	2.046e-267	839.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,2N91F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DEAD_2 domain protein	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
XH3_k127_9108217_1	521011.Mpal_1701	1.077e-101	338.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,2N963@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
XH3_k127_923756_1	368407.Memar_0702	1.858e-112	368.0	COG3635@1|root,arCOG01696@2157|Archaea,2XU1U@28890|Euryarchaeota,2N95W@224756|Methanomicrobia	224756|Methanomicrobia	G	phosphoglycerate mutase	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
XH3_k127_923756_4	456442.Mboo_0677	2.57e-19	89.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2N966@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
XH3_k127_923756_0	368407.Memar_0705	2.058e-128	417.0	COG4020@1|root,arCOG04885@2157|Archaea,2XV89@28890|Euryarchaeota,2N956@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0285 family	-	-	-	-	-	-	-	-	-	-	-	-	-
XH3_k127_923756_2	593750.Metfor_2538	9.154e-83	278.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,2N9J1@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC-1	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
XH3_k127_923756_3	593750.Metfor_2539	1.659e-35	136.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota,2N9YE@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	porD-1	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
XH3_k127_96094_1	768679.TTX_1787	3.628e-36	139.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRM8@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
XH3_k127_96094_0	593750.Metfor_0162	7.813e-159	514.0	arCOG02350@1|root,arCOG03931@1|root,arCOG02350@2157|Archaea,arCOG03931@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,PAS_4,PAS_9,TBPIP
XH3_k127_96094_3	593750.Metfor_2287	1.454e-10	70.0	COG0457@1|root,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
XH3_k127_96094_2	521674.Plim_2411	8.051e-18	96.0	COG1226@1|root,32Y28@2|Bacteria,2J0V4@203682|Planctomycetes	203682|Planctomycetes	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
## 1295 queries scanned
## Total time (seconds): 31.095081329345703
## Rate: 41.65 q/s