## Fri Feb 20 03:58:51 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/YHH1_bin.42.fa -m mmseqs --output YHH1_bin.42 --output_dir /data/result/bins/wyx/eggqs50+/YHH1_bin.42 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
YHH1_k127_10012156_4	318167.Sfri_1290	3.595e-06	56.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,2QDB5@267890|Shewanellaceae	1236|Gammaproteobacteria	K	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
YHH1_k127_10012156_3	262724.TT_C0696	1.49e-06	60.0	COG2304@1|root,COG2304@2|Bacteria,1WIWZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
YHH1_k127_10012156_1	589924.Ferp_2363	9.927e-37	153.0	COG1239@1|root,arCOG00438@2157|Archaea,2Y7DT@28890|Euryarchaeota,246ZI@183980|Archaeoglobi	183980|Archaeoglobi	H	ATPase associated with various cellular activities AAA_5	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5
YHH1_k127_10012156_0	1033737.CAEV01000062_gene2988	5.905e-69	240.0	COG0586@1|root,COG0586@2|Bacteria,1UZ4P@1239|Firmicutes,24FU4@186801|Clostridia,36F1N@31979|Clostridiaceae	186801|Clostridia	S	PFAM SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
YHH1_k127_10012156_2	1125863.JAFN01000001_gene2300	1.452e-26	115.0	COG0463@1|root,COG0463@2|Bacteria,1R547@1224|Proteobacteria,42PDC@68525|delta/epsilon subdivisions,2WKYW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
YHH1_k127_10131085_0	868131.MSWAN_0032	6.766e-57	211.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,23PAX@183925|Methanobacteria	183925|Methanobacteria	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
YHH1_k127_10131085_1	7719.XP_002124912.1	3.261e-33	139.0	arCOG07796@1|root,2QPNY@2759|Eukaryota,39IT4@33154|Opisthokonta,3BAKU@33208|Metazoa,3CSKS@33213|Bilateria,4805T@7711|Chordata	33208|Metazoa	T	Belongs to the DNase I family	DNASE1L3	GO:0000737,GO:0001775,GO:0001910,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002673,GO:0002682,GO:0002697,GO:0002703,GO:0002886,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005783,GO:0006139,GO:0006259,GO:0006308,GO:0006309,GO:0006725,GO:0006807,GO:0006915,GO:0006921,GO:0006955,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009057,GO:0009987,GO:0010623,GO:0012501,GO:0012505,GO:0016043,GO:0016787,GO:0016788,GO:0019439,GO:0022411,GO:0030154,GO:0030262,GO:0031341,GO:0031347,GO:0032101,GO:0032502,GO:0034641,GO:0034655,GO:0036230,GO:0042119,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046483,GO:0046700,GO:0046872,GO:0048468,GO:0048583,GO:0048856,GO:0048869,GO:0050727,GO:0050789,GO:0050896,GO:0065007,GO:0070948,GO:0071704,GO:0071840,GO:0080134,GO:0090304,GO:0090305,GO:0097159,GO:0097194,GO:0140097,GO:1901360,GO:1901361,GO:1901363,GO:1901575	3.1.21.1	ko:K11994,ko:K11995	-	-	-	-	ko00000,ko01000	-	-	-	Exo_endo_phos
YHH1_k127_10150508_1	1151117.AJLF01000005_gene1794	3.136e-08	59.0	COG1917@1|root,arCOG02994@2157|Archaea,2XZZJ@28890|Euryarchaeota,2448V@183968|Thermococci	183968|Thermococci	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
YHH1_k127_10150508_0	456320.Mvol_1387	2.272e-107	362.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,23Q9B@183939|Methanococci	183939|Methanococci	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
YHH1_k127_10210319_2	589924.Ferp_1786	2.542e-37	142.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota,24660@183980|Archaeoglobi	183980|Archaeoglobi	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
YHH1_k127_10210319_0	748449.Halha_1418	2.271e-64	228.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3WB8I@53433|Halanaerobiales	186801|Clostridia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
YHH1_k127_10210319_3	402881.Plav_3570	3.982e-30	126.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2TSQ0@28211|Alphaproteobacteria,1JNTQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
YHH1_k127_10210319_1	192952.MM_0233	2.852e-63	219.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,2NBIC@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions in trans to edit the amino acid moiety from	alaXM	GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A2092	tRNA-synt_2c,tRNA_SAD
YHH1_k127_10295748_1	1219076.N646_0668	0.0002616	54.0	COG2304@1|root,COG2931@1|root,COG3209@1|root,COG3391@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XSBS@135623|Vibrionales	135623|Vibrionales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,He_PIG,HemolysinCabind,VWA_2
YHH1_k127_10295748_0	946077.W5A_03294	7.506e-05	54.0	COG3391@1|root,COG4935@1|root,COG5184@1|root,COG3391@2|Bacteria,COG4935@2|Bacteria,COG5184@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia	976|Bacteroidetes	O	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,P_proprotein,Reprolysin_4,TSP_3
YHH1_k127_10306776_2	926556.Echvi_2306	1.221e-45	168.0	COG1970@1|root,COG1970@2|Bacteria,4NQ49@976|Bacteroidetes,47R3N@768503|Cytophagia	976|Bacteroidetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
YHH1_k127_10306776_3	1343739.PAP_10115	3.578e-16	83.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
YHH1_k127_10306776_1	1151117.AJLF01000003_gene662	8.16e-49	181.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,243RT@183968|Thermococci	183968|Thermococci	K	DNA-directed RNA polymerase, subunit E	rpoE1	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
YHH1_k127_10306776_7	419665.Maeo_0281	2.869e-05	48.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0YK@28890|Euryarchaeota,23R8G@183939|Methanococci	183939|Methanococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
YHH1_k127_10306776_5	693661.Arcve_0851	4.379e-10	64.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,246FE@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
YHH1_k127_10306776_4	593117.TGAM_0503	2.33e-15	77.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,244PJ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
YHH1_k127_10306776_6	114615.BRADO3265	6.403e-09	64.0	COG0270@1|root,COG2131@1|root,COG0270@2|Bacteria,COG2131@2|Bacteria,1MV9D@1224|Proteobacteria,2TSWF@28211|Alphaproteobacteria,3JZDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
YHH1_k127_10306776_0	436308.Nmar_0471	4.281e-105	368.0	COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
YHH1_k127_10309603_1	880073.Calab_0526	6.251e-18	96.0	COG1404@1|root,COG3291@1|root,COG3386@1|root,COG5276@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17,3.2.1.4	ko:K01053,ko:K01179,ko:K07214,ko:K12287	ko00030,ko00053,ko00500,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00500,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751,R06200,R11307,R11308	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko02044,ko04147	-	GH5,GH9	-	Big_5,DUF285,Esterase,He_PIG,SGL
YHH1_k127_10309603_0	555079.Toce_0910	1.335e-107	359.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42ESV@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
YHH1_k127_10385053_1	5207.AAW42072	3.13e-93	313.0	COG0148@1|root,KOG2670@2759|Eukaryota,38C66@33154|Opisthokonta,3NXC1@4751|Fungi,3UXWY@5204|Basidiomycota,3VDYZ@5234|Tremellales	4751|Fungi	G	Enolase, N-terminal domain	ENO1	GO:0000015,GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003810,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005773,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009277,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009897,GO:0009898,GO:0009986,GO:0009987,GO:0010033,GO:0015976,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016746,GO:0016755,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0019863,GO:0019865,GO:0030193,GO:0030195,GO:0030312,GO:0030445,GO:0030446,GO:0030447,GO:0030984,GO:0030985,GO:0031012,GO:0031347,GO:0031349,GO:0032101,GO:0032102,GO:0032787,GO:0032889,GO:0032991,GO:0033043,GO:0033554,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035821,GO:0036180,GO:0040007,GO:0042221,GO:0042730,GO:0042866,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044003,GO:0044088,GO:0044182,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044409,GO:0044416,GO:0044419,GO:0044421,GO:0044424,GO:0044425,GO:0044444,GO:0044445,GO:0044459,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046677,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0050896,GO:0051128,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051828,GO:0052031,GO:0052173,GO:0052200,GO:0052251,GO:0052255,GO:0052509,GO:0052510,GO:0055086,GO:0055114,GO:0061041,GO:0061045,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0062039,GO:0062040,GO:0065007,GO:0065008,GO:0070887,GO:0071214,GO:0071236,GO:0071310,GO:0071396,GO:0071470,GO:0071554,GO:0071704,GO:0071852,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0075136,GO:0080134,GO:0090407,GO:0097305,GO:0097306,GO:0097307,GO:0097308,GO:0098552,GO:0098562,GO:0104004,GO:0140096,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901700,GO:1901701,GO:1902494,GO:1903034,GO:1903035	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	iMM904.YHR174W,iND750.YHR174W	Enolase_C,Enolase_N
YHH1_k127_10385053_0	1047013.AQSP01000112_gene370	3.601e-120	397.0	COG0021@1|root,COG0021@2|Bacteria,2NS3T@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
YHH1_k127_10409750_0	756067.MicvaDRAFT_2148	4.283e-51	192.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1G2HS@1117|Cyanobacteria,1HDC4@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
YHH1_k127_10409750_1	118168.MC7420_2172	4.084e-33	141.0	COG0535@1|root,COG0535@2|Bacteria,1G1TV@1117|Cyanobacteria,1HDP9@1150|Oscillatoriales	1117|Cyanobacteria	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
YHH1_k127_10476893_1	69014.TK1491	1.148e-05	53.0	COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,243ZM@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
YHH1_k127_10476893_0	411479.BACUNI_04324	3.194e-16	93.0	COG1305@1|root,COG1305@2|Bacteria,4NJ6J@976|Bacteroidetes,2FM4K@200643|Bacteroidia,4AP0D@815|Bacteroidaceae	976|Bacteroidetes	E	Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
YHH1_k127_10574253_0	342949.PNA2_1747	1.103e-71	256.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,243PN@183968|Thermococci	183968|Thermococci	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
YHH1_k127_10692117_5	1122194.AUHU01000006_gene561	6.864e-09	63.0	COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,1S2D7@1236|Gammaproteobacteria,465VA@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG0760 Parvulin-like peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
YHH1_k127_10692117_2	272557.APE_1818	1.875e-28	118.0	COG1358@1|root,arCOG01751@2157|Archaea,2XQH4@28889|Crenarchaeota	28889|Crenarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
YHH1_k127_10692117_3	368408.Tpen_0495	1.232e-19	91.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
YHH1_k127_10692117_4	224325.AF_0766	2.752e-14	74.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota	28890|Euryarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
YHH1_k127_10692117_1	1417230.AYOT01000146_gene1920	3.328e-48	178.0	COG0105@1|root,COG0105@2|Bacteria,2J7SQ@203691|Spirochaetes	203691|Spirochaetes	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
YHH1_k127_10692117_0	634498.mru_1806	3.362e-52	188.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,23NSP@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
YHH1_k127_10730061_3	515635.Dtur_1020	1.872e-43	164.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487,iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iIT341.HP1532,iLF82_1304.LF82_0844,iNJ661.Rv3436c,iNRG857_1313.NRG857_18570,iSB619.SA_RS11245,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281,iYO844.BSU01780	GATase_6,SIS
YHH1_k127_10730061_5	1121895.Q765_05265	1.21e-23	108.0	COG1011@1|root,COG1011@2|Bacteria,4PKP6@976|Bacteroidetes,1ICYA@117743|Flavobacteriia,2NW3Y@237|Flavobacterium	976|Bacteroidetes	S	haloacid dehalogenase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
YHH1_k127_10730061_1	525904.Tter_0997	1.788e-89	304.0	COG0391@1|root,COG0391@2|Bacteria,2NP7Q@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0052	ybhK	-	-	-	-	-	-	-	-	-	-	-	UPF0052
YHH1_k127_10730061_6	1379698.RBG1_1C00001G1780	8.274e-19	89.0	COG0826@1|root,COG0826@2|Bacteria,2NS1M@2323|unclassified Bacteria	2|Bacteria	O	peptidase U32	yegQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
YHH1_k127_10730061_9	1459636.NTE_02680	2.526e-07	55.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
YHH1_k127_10730061_4	720554.Clocl_2409	1.625e-36	144.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,3WJKG@541000|Ruminococcaceae	186801|Clostridia	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	btuR	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
YHH1_k127_10730061_0	768670.Calni_0614	1.88e-277	876.0	COG0209@1|root,COG0209@2|Bacteria,2GERH@200930|Deferribacteres	200930|Deferribacteres	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
YHH1_k127_10730061_2	500633.CLOHIR_01054	1.898e-44	167.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,25R8K@186804|Peptostreptococcaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
YHH1_k127_10730061_7	374847.Kcr_0003	5.675e-14	74.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
YHH1_k127_10730061_8	246194.CHY_1596	1.398e-13	74.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,25JIA@186801|Clostridia,42HCF@68295|Thermoanaerobacterales	186801|Clostridia	D	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
YHH1_k127_10752445_2	29875.EHK22155	9.136e-14	85.0	2CY7I@1|root,2S2JI@2759|Eukaryota,3A4YR@33154|Opisthokonta,3Q6WV@4751|Fungi,3RPQ7@4890|Ascomycota,21SNG@147550|Sordariomycetes,3TV3B@5125|Hypocreales,3U1TH@5129|Hypocreaceae	4751|Fungi	S	Gamma interferon inducible lysosomal thiol reductase (GILT)	-	-	-	-	-	-	-	-	-	-	-	-	GILT
YHH1_k127_10752445_3	693661.Arcve_0163	7.037e-11	64.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,247C4@183980|Archaeoglobi	183980|Archaeoglobi	O	Hydrogenase assembly chaperone hypC hupF	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
YHH1_k127_10752445_4	604354.TSIB_1435	0.0001326	51.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,244KI@183968|Thermococci	183968|Thermococci	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
YHH1_k127_10752445_1	1121272.KB903290_gene4634	8.431e-22	102.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH1_k127_10764813_0	224308.BSU35630	1.984e-05	57.0	COG2247@1|root,COG2385@1|root,COG2247@2|Bacteria,COG2385@2|Bacteria,1V9XE@1239|Firmicutes,4HDNT@91061|Bacilli,1ZF67@1386|Bacillus	91061|Bacilli	D	Stage II sporulation protein	lytB	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	CW_binding_2,PG_binding_1,SH3_3,SpoIID
YHH1_k127_108637_2	500635.MITSMUL_03457	3.68e-18	93.0	COG2968@1|root,COG2968@2|Bacteria,1VB7C@1239|Firmicutes,4H56P@909932|Negativicutes	909932|Negativicutes	S	Psort location Periplasmic, score	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
YHH1_k127_108637_1	204669.Acid345_4026	7.626e-30	132.0	COG0628@1|root,COG0628@2|Bacteria,3Y4A3@57723|Acidobacteria,2JJ4Y@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
YHH1_k127_108637_3	762982.HMPREF9442_01315	1.296e-13	76.0	COG2095@1|root,COG2095@2|Bacteria,4NIHF@976|Bacteroidetes,2FMIJ@200643|Bacteroidia	976|Bacteroidetes	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
YHH1_k127_108637_0	523845.AQXV01000051_gene1270	9.061e-98	334.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,23Q9Q@183939|Methanococci	183939|Methanococci	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
YHH1_k127_10927261_2	1229487.AMYW01000003_gene1895	0.0001929	48.0	COG0640@1|root,COG0640@2|Bacteria,4NS8H@976|Bacteroidetes,1I4BK@117743|Flavobacteriia,2NWPP@237|Flavobacterium	976|Bacteroidetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
YHH1_k127_10927261_0	1415775.U729_2549	3.438e-130	427.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36DXY@31979|Clostridiaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
YHH1_k127_10927261_1	693661.Arcve_1092	5.76e-65	228.0	COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,246UX@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
YHH1_k127_10946530_1	545693.BMQ_2157	0.0005501	52.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	blt	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08153,ko:K19578	-	M00717,M00765	-	-	ko00000,ko00002,ko02000	2.A.1.2.70,2.A.1.2.8	-	iYO844.BSU26590	MFS_1,MFS_1_like,MFS_2,Sugar_tr
YHH1_k127_10946530_0	572544.Ilyop_0967	6.984e-70	244.0	COG0501@1|root,COG0501@2|Bacteria,3790I@32066|Fusobacteria	32066|Fusobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
YHH1_k127_10947637_2	867845.KI911784_gene3634	1.123e-14	78.0	COG1994@1|root,COG1994@2|Bacteria,2GAEP@200795|Chloroflexi,375U8@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_10947637_3	1293048.CBMB010000003_gene1068	0.0004646	47.0	arCOG04780@1|root,arCOG04780@2157|Archaea,2XTYH@28890|Euryarchaeota,23T46@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HPP,Usp
YHH1_k127_10947637_0	391623.TERMP_01877	1.305e-45	174.0	COG1637@1|root,arCOG01304@2157|Archaea,2XUC8@28890|Euryarchaeota,243KJ@183968|Thermococci	183968|Thermococci	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
YHH1_k127_10947637_1	439481.Aboo_0226	2.057e-21	97.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,3F39F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Archaeal Nre, N-terminal	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
YHH1_k127_10969052_0	573064.Mefer_0609	8.285e-20	93.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,23QVX@183939|Methanococci	183939|Methanococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
YHH1_k127_10969052_2	159749.K0TDS1	8.305e-07	58.0	COG2097@1|root,KOG0893@2759|Eukaryota,2XD6P@2836|Bacillariophyta	2836|Bacillariophyta	J	Ribosomal_L31e	-	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
YHH1_k127_10969052_1	391623.TERMP_00152	1.457e-19	90.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
YHH1_k127_10983184_0	536227.CcarbDRAFT_1356	2.82e-173	556.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,36DSW@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
YHH1_k127_10983184_2	339860.Msp_1125	6.592e-07	60.0	COG1378@1|root,arCOG02037@2157|Archaea,2XZRE@28890|Euryarchaeota,23P59@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
YHH1_k127_10983184_1	555088.DealDRAFT_1791	1.755e-17	94.0	COG0683@1|root,COG0683@2|Bacteria,1UY3Q@1239|Firmicutes,249YE@186801|Clostridia,42JV2@68298|Syntrophomonadaceae	186801|Clostridia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
YHH1_k127_1155819_1	167539.Pro_1193	1.153e-08	59.0	COG4095@1|root,COG4095@2|Bacteria	2|Bacteria	S	Sugar efflux transporter for intercellular exchange	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
YHH1_k127_1155819_0	443143.GM18_4158	2.213e-73	257.0	COG3872@1|root,COG3872@2|Bacteria,1RCB0@1224|Proteobacteria,42R3I@68525|delta/epsilon subdivisions,2WMZR@28221|Deltaproteobacteria,43U2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
YHH1_k127_1179067_1	344747.PM8797T_26600	5.609e-14	82.0	COG0510@1|root,COG0510@2|Bacteria,2J040@203682|Planctomycetes	203682|Planctomycetes	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
YHH1_k127_1179067_0	1469557.JSWF01000045_gene472	6.926e-28	125.0	COG2356@1|root,COG2356@2|Bacteria,4NINJ@976|Bacteroidetes,1HZEY@117743|Flavobacteriia	976|Bacteroidetes	L	endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	LTD
YHH1_k127_1252242_0	857293.CAAU_1997	2.714e-182	587.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,36E5Z@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
YHH1_k127_1355157_0	529709.PYCH_18150	3.749e-113	372.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,242PW@183968|Thermococci	183968|Thermococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
YHH1_k127_1355157_3	634498.mru_0482	1.595e-09	63.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y188@28890|Euryarchaeota,23P97@183925|Methanobacteria	183925|Methanobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
YHH1_k127_1355157_2	877455.Metbo_2249	4.667e-31	133.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,23P3U@183925|Methanobacteria	183925|Methanobacteria	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
YHH1_k127_1355157_1	186497.PF1991	7.728e-44	169.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,243FN@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
YHH1_k127_1355157_5	1042877.GQS_04635	9.533e-07	56.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota,243TB@183968|Thermococci	183968|Thermococci	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
YHH1_k127_1355157_4	402880.MmarC5_1583	1.012e-07	56.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,23R0X@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
YHH1_k127_1406792_1	1121289.JHVL01000013_gene1674	6.486e-33	138.0	COG1541@1|root,COG1541@2|Bacteria,1V5FH@1239|Firmicutes,24DHW@186801|Clostridia,36W0R@31979|Clostridiaceae	186801|Clostridia	H	coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
YHH1_k127_1406792_0	1195236.CTER_1970	5.256e-96	326.0	COG0438@1|root,COG0438@2|Bacteria,1TR0Y@1239|Firmicutes,24B5E@186801|Clostridia	186801|Clostridia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
YHH1_k127_1449876_2	453591.Igni_0451	3.44e-23	102.0	COG2058@1|root,arCOG04287@2157|Archaea,2XQSC@28889|Crenarchaeota	28889|Crenarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
YHH1_k127_1449876_0	224719.Abm4_0258	3.422e-62	224.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23NKW@183925|Methanobacteria	183925|Methanobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
YHH1_k127_1449876_1	1151117.AJLF01000002_gene504	4.148e-37	149.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,242ZJ@183968|Thermococci	183968|Thermococci	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
YHH1_k127_1457767_0	497964.CfE428DRAFT_1683	5.24e-82	284.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
YHH1_k127_1457767_1	877455.Metbo_0534	6.725e-39	164.0	COG1287@1|root,arCOG02044@2157|Archaea,2XU59@28890|Euryarchaeota,23NKH@183925|Methanobacteria	183925|Methanobacteria	M	PFAM Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18,2.4.99.21	ko:K07151,ko:K21306	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
YHH1_k127_1504629_3	868131.MSWAN_2439	3.441e-08	62.0	COG0681@1|root,arCOG01739@2157|Archaea,2XYEA@28890|Euryarchaeota,23P1Z@183925|Methanobacteria	183925|Methanobacteria	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
YHH1_k127_1504629_2	411477.PARMER_00086	1.227e-10	72.0	COG1091@1|root,COG1091@2|Bacteria,4NE3K@976|Bacteroidetes,2FN7H@200643|Bacteroidia,22WWK@171551|Porphyromonadaceae	976|Bacteroidetes	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
YHH1_k127_1504629_0	269797.Mbar_A1752	1.146e-69	254.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
YHH1_k127_1504629_1	593117.TGAM_0865	2.629e-48	177.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,243T7@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
YHH1_k127_1571559_0	1054217.TALC_00119	6.308e-111	366.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,241M1@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,eIF2_C
YHH1_k127_1571559_1	1041930.Mtc_2151	5.436e-39	151.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,2N9K7@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
YHH1_k127_1633226_0	358396.C445_09765	1.424e-07	58.0	COG2512@1|root,arCOG00386@2157|Archaea,2XZKM@28890|Euryarchaeota,23W4D@183963|Halobacteria	183963|Halobacteria	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
YHH1_k127_1635025_0	391623.TERMP_02169	1.989e-101	338.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,243E8@183968|Thermococci	183968|Thermococci	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
YHH1_k127_1635025_1	33169.AAS50557	1.216e-10	69.0	COG0500@1|root,KOG1499@2759|Eukaryota,38BN9@33154|Opisthokonta,3NV5S@4751|Fungi,3QN5A@4890|Ascomycota,3RSA2@4891|Saccharomycetes,3RY3S@4893|Saccharomycetaceae	4751|Fungi	KOT	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family	HMT1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0006355,GO:0006357,GO:0006403,GO:0006405,GO:0006406,GO:0006464,GO:0006479,GO:0006611,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006996,GO:0008104,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008469,GO:0008757,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0015031,GO:0015833,GO:0015931,GO:0016043,GO:0016273,GO:0016274,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018193,GO:0018195,GO:0018216,GO:0019219,GO:0019222,GO:0019538,GO:0019919,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031503,GO:0031554,GO:0032259,GO:0032784,GO:0032786,GO:0032968,GO:0033036,GO:0034243,GO:0034613,GO:0034969,GO:0035241,GO:0035242,GO:0035246,GO:0035247,GO:0036211,GO:0042054,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043242,GO:0043244,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0046907,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050657,GO:0050658,GO:0050789,GO:0050794,GO:0051028,GO:0051128,GO:0051129,GO:0051168,GO:0051169,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051234,GO:0051236,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051641,GO:0051649,GO:0060255,GO:0060567,GO:0065007,GO:0070727,GO:0071166,GO:0071426,GO:0071427,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0080090,GO:0140096,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.319	ko:K11434	ko04068,ko04922,map04068,map04922	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko00001,ko01000,ko03036	-	-	-	Methyltransf_25,PrmA
YHH1_k127_1636800_0	269797.Mbar_A2931	4.69e-09	71.0	COG3291@1|root,arCOG06836@1|root,arCOG02546@2157|Archaea,arCOG06836@2157|Archaea	2157|Archaea	P	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	BNR_2,CARDB,Kelch_4,PKD,VWA
YHH1_k127_1647521_1	1183377.Py04_1101	1.44e-106	362.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,242YE@183968|Thermococci	183968|Thermococci	J	Phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
YHH1_k127_1647521_0	868131.MSWAN_1074	3.164e-111	377.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,23NUT@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
YHH1_k127_1647521_3	926690.KE386573_gene2140	3.397e-17	91.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7G0@28890|Euryarchaeota,23Z51@183963|Halobacteria	183963|Halobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_1647521_4	1449976.KALB_7876	5.054e-13	79.0	2DUT4@1|root,33S4K@2|Bacteria,2H3IW@201174|Actinobacteria	201174|Actinobacteria	J	Ribosomal RNA methyltransferase (FmrO)	-	-	2.1.1.179	ko:K18845	-	-	-	-	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	FmrO
YHH1_k127_1647521_2	1343739.PAP_07980	2.534e-52	198.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
YHH1_k127_1687989_3	1502850.FG91_03013	3.988e-10	61.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,2TSRN@28211|Alphaproteobacteria,2K1C4@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
YHH1_k127_1687989_2	1041930.Mtc_2166	4.211e-30	129.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2NATE@224756|Methanomicrobia	224756|Methanomicrobia	T	RIO1 family	-	-	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
YHH1_k127_1687989_1	186497.PF1438	3.016e-47	190.0	COG1750@1|root,arCOG01937@2157|Archaea,2XUEB@28890|Euryarchaeota,242IS@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
YHH1_k127_1687989_0	502558.EGYY_01050	2.16e-66	243.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4CUX7@84998|Coriobacteriia	84998|Coriobacteriia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
YHH1_k127_1715733_1	547144.HydHO_1350	4.755e-14	80.0	COG0546@1|root,COG0546@2|Bacteria,2G554@200783|Aquificae	200783|Aquificae	S	PFAM Haloacid dehalogenase domain protein hydrolase	gph	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
YHH1_k127_1715733_3	1150474.JQJI01000015_gene634	0.0009913	49.0	COG0125@1|root,COG0125@2|Bacteria,2GD5T@200918|Thermotogae	200918|Thermotogae	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1099	Thymidylate_kin
YHH1_k127_1715733_0	349521.HCH_06817	2.066e-66	238.0	COG0524@1|root,COG0524@2|Bacteria,1QTMT@1224|Proteobacteria,1S1JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
YHH1_k127_1715733_2	1365176.N186_04310	8.506e-05	49.0	COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
YHH1_k127_1790857_0	589924.Ferp_0654	1.816e-06	53.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,246I7@183980|Archaeoglobi	183980|Archaeoglobi	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
YHH1_k127_1858588_0	404589.Anae109_1034	3.158e-06	55.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
YHH1_k127_1861398_1	342949.PNA2_0170	4.406e-33	132.0	COG0463@1|root,arCOG00896@2157|Archaea,2Y7MP@28890|Euryarchaeota,242VC@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,HAD_2
YHH1_k127_1861398_0	1499967.BAYZ01000026_gene1631	7.178e-141	469.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
YHH1_k127_1861398_2	439481.Aboo_1545	5.019e-14	76.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
YHH1_k127_1924801_0	1002367.HMPREF0673_01864	3.52e-46	173.0	COG1704@1|root,COG1704@2|Bacteria,4NMD3@976|Bacteroidetes,2FNPV@200643|Bacteroidia	976|Bacteroidetes	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
YHH1_k127_1924801_1	411469.EUBHAL_02314	2.493e-23	109.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,25WUY@186806|Eubacteriaceae	186801|Clostridia	FG	Psort location Cytoplasmic, score	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
YHH1_k127_1924801_2	639282.DEFDS_1906	1.736e-09	66.0	COG0537@1|root,COG0537@2|Bacteria,2GFP5@200930|Deferribacteres	200930|Deferribacteres	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
YHH1_k127_1935391_0	573063.Metin_0731	1.896e-60	216.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,23Q87@183939|Methanococci	183939|Methanococci	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
YHH1_k127_1935391_1	521460.Athe_1544	5.246e-07	63.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,42GR1@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M29, aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
YHH1_k127_1956310_0	243232.MJ_1305	5.536e-08	64.0	COG1708@1|root,arCOG01202@2157|Archaea,2Y57P@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
YHH1_k127_203558_1	452662.SJA_C1-34910	0.0003768	50.0	COG4424@1|root,COG4424@2|Bacteria,1N2S4@1224|Proteobacteria,2UMTM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
YHH1_k127_203558_0	1347087.CBYO010000001_gene243	1.603e-06	59.0	28Q0Y@1|root,2ZCJK@2|Bacteria,1V1DQ@1239|Firmicutes,4HFUD@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_2063606_1	1296416.JACB01000070_gene74	1.982e-06	60.0	COG1404@1|root,COG3291@1|root,COG3975@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3975@2|Bacteria,4NHDH@976|Bacteroidetes,1IF30@117743|Flavobacteriia,2YIBS@290174|Aquimarina	976|Bacteroidetes	O	Peptidase family M9 N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M9,Peptidase_M9_N
YHH1_k127_2063606_0	439481.Aboo_0131	1.208e-23	115.0	COG1708@1|root,COG1895@1|root,arCOG01204@2157|Archaea,arCOG02123@2157|Archaea,2Y5D9@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
YHH1_k127_2071962_1	386456.JQKN01000004_gene195	1.413e-61	220.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,23PJA@183925|Methanobacteria	183925|Methanobacteria	S	Phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
YHH1_k127_2071962_0	536232.CLM_0536	3.041e-62	229.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,36DTA@31979|Clostridiaceae	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
YHH1_k127_2093222_2	1192034.CAP_5180	3.366e-05	57.0	COG3055@1|root,COG4412@1|root,COG3055@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PKD
YHH1_k127_2093222_1	865861.AZSU01000003_gene2090	2.03e-34	139.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,36IQB@31979|Clostridiaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
YHH1_k127_2093222_0	903814.ELI_3543	1.708e-74	253.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,25VH9@186806|Eubacteriaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
YHH1_k127_2147482_2	1307759.JOMJ01000003_gene2066	0.0006884	52.0	COG1082@1|root,COG1082@2|Bacteria,1N8KJ@1224|Proteobacteria,42SR1@68525|delta/epsilon subdivisions,2WP5P@28221|Deltaproteobacteria,2MB20@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
YHH1_k127_2147482_0	439481.Aboo_0131	2.846e-29	128.0	COG1708@1|root,COG1895@1|root,arCOG01204@2157|Archaea,arCOG02123@2157|Archaea,2Y5D9@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
YHH1_k127_2147482_1	653045.Strvi_0870	1.129e-05	53.0	2F8R6@1|root,3413E@2|Bacteria,2IAE4@201174|Actinobacteria	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH1_k127_2161176_2	523794.Lebu_2212	4.152e-10	66.0	COG0683@1|root,COG0683@2|Bacteria,3796J@32066|Fusobacteria	32066|Fusobacteria	E	Psort location Periplasmic, score	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
YHH1_k127_2161176_0	309799.DICTH_0783	2.401e-63	231.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	livJ	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
YHH1_k127_2161176_1	453591.Igni_0883	3.93e-11	74.0	COG0704@1|root,arCOG00318@2157|Archaea	2157|Archaea	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
YHH1_k127_2161176_3	1380354.JIAN01000006_gene999	0.0003104	53.0	COG2334@1|root,COG2334@2|Bacteria,2GXZI@201174|Actinobacteria	201174|Actinobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
YHH1_k127_2203178_0	28258.KP05_02015	1.513e-14	87.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XHMA@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
YHH1_k127_2203178_1	926561.KB900621_gene2738	2.084e-11	77.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WAJU@53433|Halanaerobiales	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
YHH1_k127_2235452_0	604354.TSIB_0399	1.033e-52	196.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,242NB@183968|Thermococci	183968|Thermococci	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
YHH1_k127_236996_1	1192034.CAP_3276	6.326e-34	138.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQAW@28221|Deltaproteobacteria,2YZNP@29|Myxococcales	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
YHH1_k127_236996_0	368408.Tpen_0762	1.142e-49	186.0	COG0020@1|root,arCOG01532@2157|Archaea,2XPUG@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.89	ko:K00806,ko:K15888	ko00900,ko01110,map00900,map01110	-	R06447,R09730	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
YHH1_k127_2477959_1	1184251.TCELL_1205	8.907e-05	57.0	COG0433@1|root,arCOG00282@2157|Archaea,2XQ27@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART AAA ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
YHH1_k127_2477959_0	368407.Memar_1023	2.281e-06	53.0	COG0375@1|root,arCOG04426@2157|Archaea,2Y0W9@28890|Euryarchaeota,2NB6Y@224756|Methanomicrobia	224756|Methanomicrobia	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
YHH1_k127_2500265_0	1500890.JQNL01000001_gene3155	9.146e-26	121.0	COG3179@1|root,COG3409@1|root,COG3179@2|Bacteria,COG3409@2|Bacteria,1RC1P@1224|Proteobacteria,1RN66@1236|Gammaproteobacteria,1X5XS@135614|Xanthomonadales	1236|Gammaproteobacteria	M	Chitinase class I	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19,PG_binding_1
YHH1_k127_2500265_1	160799.PBOR_05775	4.573e-14	87.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4HGM6@91061|Bacilli,26ST2@186822|Paenibacillaceae	91061|Bacilli	M	Membrane proteins related to metalloendopeptidases	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
YHH1_k127_2548612_2	1094715.CM001373_gene957	1.959e-09	66.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1JD6Z@118969|Legionellales	118969|Legionellales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
YHH1_k127_2548612_1	269797.Mbar_A1360	2.215e-72	256.0	COG0500@1|root,arCOG05015@2157|Archaea,2XX0Y@28890|Euryarchaeota,2NA7G@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_15
YHH1_k127_2548612_0	237368.SCABRO_03950	5.731e-111	368.0	COG1180@1|root,COG1180@2|Bacteria,2IYWA@203682|Planctomycetes	203682|Planctomycetes	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
YHH1_k127_2548612_3	403833.Pmob_0717	2.129e-05	53.0	COG1597@1|root,COG1597@2|Bacteria,2GCWI@200918|Thermotogae	200918|Thermotogae	I	diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
YHH1_k127_267886_1	679926.Mpet_0042	4.137e-12	74.0	COG0392@1|root,COG0500@1|root,arCOG00899@2157|Archaea,arCOG04347@2157|Archaea,2Y7ZD@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_267886_0	1244869.H261_13935	2.364e-72	256.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TUPK@28211|Alphaproteobacteria,2JPEX@204441|Rhodospirillales	204441|Rhodospirillales	C	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase	bchE	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
YHH1_k127_270329_2	273068.TTE2463	1.305e-18	90.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
YHH1_k127_270329_3	485914.Hmuk_3237	3.116e-09	64.0	COG2512@1|root,arCOG00386@2157|Archaea,2XZKM@28890|Euryarchaeota,23W4D@183963|Halobacteria	183963|Halobacteria	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
YHH1_k127_270329_1	634498.mru_0591	2.033e-33	145.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,23NN9@183925|Methanobacteria	183925|Methanobacteria	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
YHH1_k127_270329_0	351160.LRC303	7.873e-250	795.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
YHH1_k127_2712456_3	1047013.AQSP01000127_gene472	5.827e-39	151.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BPD_transp_2
YHH1_k127_2712456_1	944480.ATUV01000002_gene389	4.841e-60	216.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42YQS@68525|delta/epsilon subdivisions,2WUCI@28221|Deltaproteobacteria,2M724@213113|Desulfurellales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
YHH1_k127_2712456_0	632335.Calkr_1378	8.392e-77	264.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,42EMQ@68295|Thermoanaerobacterales	186801|Clostridia	E	ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
YHH1_k127_2712456_4	305900.GV64_01085	9.543e-18	93.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,1RS6X@1236|Gammaproteobacteria,1XITG@135619|Oceanospirillales	135619|Oceanospirillales	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_2712456_2	555088.DealDRAFT_1791	3.655e-41	166.0	COG0683@1|root,COG0683@2|Bacteria,1UY3Q@1239|Firmicutes,249YE@186801|Clostridia,42JV2@68298|Syntrophomonadaceae	186801|Clostridia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
YHH1_k127_2712456_5	273075.Ta0685	0.0006451	50.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y64V@28890|Euryarchaeota,241ZI@183967|Thermoplasmata	183967|Thermoplasmata	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
YHH1_k127_3101826_0	1094980.Mpsy_0339	5.776e-13	74.0	COG1226@1|root,arCOG01958@2157|Archaea,2Y1ZP@28890|Euryarchaeota,2NA44@224756|Methanomicrobia	224756|Methanomicrobia	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
YHH1_k127_3206654_0	1230460.C495_05267	4.615e-43	172.0	COG1215@1|root,arCOG01389@2157|Archaea,2XVEG@28890|Euryarchaeota,23UEZ@183963|Halobacteria	183963|Halobacteria	M	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
YHH1_k127_3206654_1	285535.JOEY01000023_gene144	2.309e-05	55.0	COG1378@1|root,COG1378@2|Bacteria,2IGKT@201174|Actinobacteria	201174|Actinobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_3210767_3	351160.RCIX2513	4.742e-10	66.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
YHH1_k127_3210767_1	487796.Flav2ADRAFT_0858	8.274e-25	115.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,1HWY3@117743|Flavobacteriia	976|Bacteroidetes	S	von Willebrand factor, type A	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
YHH1_k127_3210767_2	314230.DSM3645_26889	9.33e-19	94.0	COG1721@1|root,COG1721@2|Bacteria,2IXT7@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
YHH1_k127_3210767_4	1229909.NSED_09375	2.527e-08	58.0	COG1721@1|root,arCOG02745@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
YHH1_k127_3210767_0	390236.BafPKo_0173	2.814e-86	296.0	COG0714@1|root,COG0714@2|Bacteria,2J5VG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
YHH1_k127_322250_0	572546.Arcpr_0333	8.637e-16	82.0	COG0394@1|root,arCOG04425@2157|Archaea	2157|Archaea	T	low molecular weight	-	-	1.20.4.1,3.1.3.48	ko:K01104,ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc,Metallophos
YHH1_k127_322250_2	868864.Dester_0464	7.023e-07	60.0	COG1082@1|root,COG1082@2|Bacteria,2G4GU@200783|Aquificae	200783|Aquificae	G	Xylose isomerase domain-containing protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
YHH1_k127_322250_1	545697.HMPREF0216_00526	2.863e-11	68.0	COG1512@1|root,COG1512@2|Bacteria,1V5YF@1239|Firmicutes,249DU@186801|Clostridia,36EEB@31979|Clostridiaceae	186801|Clostridia	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
YHH1_k127_3246992_1	192952.MM_1537	7.11e-26	111.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,2NA1Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
YHH1_k127_3246992_0	634498.mru_0392	1.038e-116	386.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,23NP9@183925|Methanobacteria	183925|Methanobacteria	S	C-terminal region of MMR_HSR1 domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
YHH1_k127_3246992_3	1312959.KI914666_gene3647	4.148e-13	81.0	COG0683@1|root,COG0683@2|Bacteria,2HFFK@201174|Actinobacteria,1WAAN@1268|Micrococcaceae	201174|Actinobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
YHH1_k127_3246992_2	78245.Xaut_1568	1.048e-21	104.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,2UHQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_3261595_4	452637.Oter_2664	1.349e-05	47.0	COG0297@1|root,COG0297@2|Bacteria,46S9F@74201|Verrucomicrobia,3K7ES@414999|Opitutae	414999|Opitutae	G	Starch synthase catalytic domain	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
YHH1_k127_3261595_2	1298920.KI911353_gene2366	1.813e-60	217.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,21XPI@1506553|Lachnoclostridium	186801|Clostridia	J	Seryl-tRNA synthetase N-terminal domain	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
YHH1_k127_3261595_3	589924.Ferp_0944	2.371e-39	156.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota,246N7@183980|Archaeoglobi	183980|Archaeoglobi	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH1_k127_3261595_0	439481.Aboo_0196	2.053e-67	253.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,3F2IN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	HELICc2	rad3b	-	3.6.4.12	ko:K03722,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2,ResIII
YHH1_k127_3261595_1	515635.Dtur_0327	2.576e-65	226.0	COG1533@1|root,COG1533@2|Bacteria	2|Bacteria	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
YHH1_k127_3268953_0	1041930.Mtc_2105	7.735e-53	194.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,2N94X@224756|Methanomicrobia	224756|Methanomicrobia	J	TGS domain protein	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
YHH1_k127_3272668_0	880073.Calab_1123	3.782e-99	334.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
YHH1_k127_3272668_1	573063.Metin_0137	9.122e-86	300.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,23QDG@183939|Methanococci	183939|Methanococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C,Intein_splicing,LAGLIDADG_3
YHH1_k127_328166_2	269797.Mbar_A0619	6.303e-31	128.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
YHH1_k127_328166_1	1220534.B655_1460	7.972e-35	143.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,23NY2@183925|Methanobacteria	183925|Methanobacteria	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
YHH1_k127_328166_0	264462.Bd1631	3.349e-77	265.0	COG4912@1|root,COG4912@2|Bacteria,1QSBJ@1224|Proteobacteria,42QNI@68525|delta/epsilon subdivisions,2WN26@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
YHH1_k127_3285482_3	572546.Arcpr_1269	6.797e-27	115.0	COG0535@1|root,arCOG00940@2157|Archaea,2XTQH@28890|Euryarchaeota	28890|Euryarchaeota	S	Radical SAM	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
YHH1_k127_3285482_1	236814.IX39_16655	2.291e-33	136.0	COG1418@1|root,COG1418@2|Bacteria,4NFAG@976|Bacteroidetes,1I40V@117743|Flavobacteriia,3ZUAY@59732|Chryseobacterium	976|Bacteroidetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HD
YHH1_k127_3285482_6	224719.Abm4_1544	2.868e-09	68.0	COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,23P3M@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
YHH1_k127_3285482_2	1449126.JQKL01000055_gene2205	1.912e-30	126.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	rppH_2	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
YHH1_k127_3285482_5	311424.DhcVS_669	1.794e-16	83.0	COG4852@1|root,COG4852@2|Bacteria,2GAUE@200795|Chloroflexi,34DDH@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Predicted membrane protein (DUF2177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2177
YHH1_k127_3285482_0	186497.PF0983	2.284e-48	182.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2434V@183968|Thermococci	183968|Thermococci	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N,Rad1
YHH1_k127_3285482_4	877455.Metbo_0821	3.725e-22	99.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,23NWQ@183925|Methanobacteria	183925|Methanobacteria	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
YHH1_k127_346293_2	644281.MFS40622_0616	4.673e-27	119.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,23QPZ@183939|Methanococci	183939|Methanococci	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
YHH1_k127_346293_3	237368.SCABRO_02691	3.361e-06	53.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
YHH1_k127_346293_1	1094980.Mpsy_0116	9.965e-67	237.0	COG1721@1|root,arCOG02745@2157|Archaea,2XVGA@28890|Euryarchaeota,2NAC9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
YHH1_k127_346293_0	192952.MM_0372	8.489e-126	409.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,2NA7N@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
YHH1_k127_3497541_0	391623.TERMP_01899	2.533e-94	327.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,242XB@183968|Thermococci	183968|Thermococci	U	type II secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Intein_splicing,LAGLIDADG_3,T2SSE
YHH1_k127_3614404_1	1267535.KB906767_gene5241	3.115e-12	70.0	COG3379@1|root,COG3379@2|Bacteria,3Y7EC@57723|Acidobacteria	57723|Acidobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
YHH1_k127_3614404_0	272844.PAB1411	2.804e-81	280.0	COG0463@1|root,arCOG00894@2157|Archaea,2XUJ6@28890|Euryarchaeota,242XZ@183968|Thermococci	183968|Thermococci	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
YHH1_k127_3625538_2	926550.CLDAP_27650	5.88e-11	68.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
YHH1_k127_3625538_0	215358.XP_010730107.1	1.031e-162	527.0	COG0008@1|root,COG0442@1|root,KOG1147@2759|Eukaryota,KOG4163@2759|Eukaryota,38B44@33154|Opisthokonta,3BBW2@33208|Metazoa,3CX8R@33213|Bilateria,4835V@7711|Chordata,48ZMJ@7742|Vertebrata,49WBM@7898|Actinopterygii	33208|Metazoa	J	glutamyl-prolyl-tRNA synthetase	EPRS	GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004818,GO:0004827,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006424,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009719,GO:0009725,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010876,GO:0015711,GO:0015718,GO:0015849,GO:0015908,GO:0015909,GO:0016020,GO:0016043,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0019899,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032868,GO:0032869,GO:0032870,GO:0032991,GO:0033036,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034641,GO:0034645,GO:0034660,GO:0035613,GO:0042221,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044539,GO:0045087,GO:0046483,GO:0046872,GO:0046914,GO:0046942,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071345,GO:0071346,GO:0071375,GO:0071417,GO:0071495,GO:0071702,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097452,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1990904,GO:2000112,GO:2000113	6.1.1.15,6.1.1.17	ko:K01885,ko:K14163	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03661,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	GST_C,GST_C_3,HGTP_anticodon,ProRS-C_1,WHEP-TRS,tRNA-synt_1c,tRNA-synt_1c_C,tRNA-synt_2b
YHH1_k127_3625538_1	573063.Metin_0322	7.476e-21	100.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,23QSG@183939|Methanococci	183939|Methanococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha,TF_Zn_Ribbon
YHH1_k127_3656622_1	572546.Arcpr_1100	1.294e-30	124.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota	28890|Euryarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
YHH1_k127_3656622_0	1047013.AQSP01000130_gene1853	1.694e-95	324.0	COG2887@1|root,COG2887@2|Bacteria,2NQTZ@2323|unclassified Bacteria	2|Bacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	FtsK_SpoIIIE,PDDEXK_1
YHH1_k127_3656622_2	522772.Dacet_0237	1.531e-08	66.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
YHH1_k127_3684236_0	574375.BAGA_19440	2.49e-36	147.0	COG0667@1|root,COG0667@2|Bacteria,1V40S@1239|Firmicutes,4HTYI@91061|Bacilli	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
YHH1_k127_3684236_1	247490.KSU1_C1608	3.636e-11	76.0	COG3379@1|root,COG3379@2|Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
YHH1_k127_3707327_1	644968.DFW101_1956	2.436e-09	59.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2M84C@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
YHH1_k127_3707327_0	1340434.AXVA01000019_gene924	2.925e-79	278.0	COG3387@1|root,COG3387@2|Bacteria,1V0CI@1239|Firmicutes,4HCZU@91061|Bacilli,1ZD6W@1386|Bacillus	91061|Bacilli	G	Glycosyl hydrolases family 15	-	-	-	ko:K07190	ko04020,ko04910,ko04922,map04020,map04910,map04922	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_15
YHH1_k127_3763148_5	1210908.HSB1_44590	7.452e-09	64.0	COG0500@1|root,arCOG01402@2157|Archaea,2XYWP@28890|Euryarchaeota,23WPJ@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
YHH1_k127_3763148_4	342949.PNA2_1206	1.042e-09	68.0	COG0681@1|root,arCOG01739@2157|Archaea,2XYEA@28890|Euryarchaeota,24456@183968|Thermococci	183968|Thermococci	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
YHH1_k127_3763148_3	420247.Msm_1354	2.284e-23	102.0	COG1594@1|root,arCOG00579@2157|Archaea,2XZ6S@28890|Euryarchaeota,23P4D@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
YHH1_k127_3763148_6	1343739.PAP_02865	8.475e-07	53.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,244II@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
YHH1_k127_3763148_0	1047013.AQSP01000099_gene1493	2.356e-67	234.0	COG2131@1|root,COG2131@2|Bacteria,2NPW9@2323|unclassified Bacteria	2|Bacteria	F	MafB19-like deaminase	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
YHH1_k127_3763148_2	1047013.AQSP01000099_gene1494	1.314e-37	147.0	COG0237@1|root,COG0237@2|Bacteria	2|Bacteria	H	dephospho-CoA kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
YHH1_k127_3763148_1	56780.SYN_00357	9.617e-62	224.0	COG1351@1|root,COG1351@2|Bacteria,1QF4I@1224|Proteobacteria,43A0P@68525|delta/epsilon subdivisions,2X9Q1@28221|Deltaproteobacteria,2MSCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thymidylate synthase complementing protein	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
YHH1_k127_3795388_0	234267.Acid_4159	0.0007574	51.0	COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria	57723|Acidobacteria	U	type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
YHH1_k127_3963639_2	521011.Mpal_2447	1.672e-17	83.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
YHH1_k127_3963639_1	1499967.BAYZ01000090_gene4944	1.034e-65	231.0	COG1215@1|root,COG1215@2|Bacteria,2NRME@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
YHH1_k127_3963639_0	1499967.BAYZ01000090_gene4943	9.455e-96	325.0	COG0535@1|root,COG0535@2|Bacteria,2NPKA@2323|unclassified Bacteria	2|Bacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
YHH1_k127_3991022_2	111105.HR09_11000	1.442e-26	121.0	COG3930@1|root,COG3930@2|Bacteria	2|Bacteria	E	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
YHH1_k127_3991022_1	70601.3258079	4.429e-47	177.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
YHH1_k127_3991022_0	186497.PF1843	2.607e-153	526.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
YHH1_k127_3991022_4	1118054.CAGW01000014_gene261	2.515e-06	53.0	COG3860@1|root,COG3860@2|Bacteria,1TPHH@1239|Firmicutes,4HCHE@91061|Bacilli,26TD0@186822|Paenibacillaceae	91061|Bacilli	K	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,GerE
YHH1_k127_3991022_3	316274.Haur_3582	1.984e-21	105.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
YHH1_k127_4000673_0	522772.Dacet_1132	4.148e-37	151.0	COG0189@1|root,COG0189@2|Bacteria,2GGAF@200930|Deferribacteres	200930|Deferribacteres	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
YHH1_k127_4000673_1	192952.MM_2527	6.479e-10	63.0	arCOG01059@1|root,arCOG01059@2157|Archaea,2Y0H1@28890|Euryarchaeota,2N9Y0@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_4050157_0	70601.3258332	1.598e-42	171.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,243FH@183968|Thermococci	183968|Thermococci	L	replication factor A	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
YHH1_k127_4050157_2	1464048.JNZS01000017_gene3583	0.0005631	49.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria,4DBYK@85008|Micromonosporales	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C,Pectate_lyase_3
YHH1_k127_4050157_1	1214065.BAGV01000019_gene2546	1.331e-10	68.0	COG1988@1|root,COG1988@2|Bacteria,1Q0WR@1224|Proteobacteria,1RU1K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane-bound metal-dependent	ydjM	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031668,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
YHH1_k127_4128112_0	351160.RCIX949	6.039e-113	392.0	COG4962@1|root,arCOG01818@2157|Archaea,2XTN5@28890|Euryarchaeota,2N9AG@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
YHH1_k127_4196193_1	1183377.Py04_1243	9.557e-05	54.0	COG5306@1|root,arCOG03512@2157|Archaea,2Y0GI@28890|Euryarchaeota,242SV@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF2341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2341
YHH1_k127_4196193_0	304371.MCP_0268	2.075e-13	74.0	COG1430@1|root,arCOG03113@2157|Archaea,2XYZP@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
YHH1_k127_4210567_1	647113.Metok_1204	1.168e-29	128.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,23QM5@183939|Methanococci	183939|Methanococci	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
YHH1_k127_4210567_0	1209989.TepiRe1_0729	5.922e-80	272.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,42EQA@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
YHH1_k127_4324077_0	523850.TON_0507	1.49e-97	331.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
YHH1_k127_4324077_1	112098.XP_008611897.1	7.199e-94	318.0	COG1899@1|root,KOG2924@2759|Eukaryota	2759|Eukaryota	O	deoxyhypusine synthase activity	DHPS	GO:0002682,GO:0002684,GO:0002694,GO:0002696,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006417,GO:0006464,GO:0006518,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008216,GO:0008284,GO:0008612,GO:0009056,GO:0009058,GO:0009059,GO:0009308,GO:0009310,GO:0009553,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0022407,GO:0022409,GO:0022607,GO:0030155,GO:0031323,GO:0031326,GO:0032268,GO:0032501,GO:0032502,GO:0032944,GO:0032946,GO:0033500,GO:0034038,GO:0034248,GO:0034641,GO:0034645,GO:0036211,GO:0042102,GO:0042127,GO:0042129,GO:0042402,GO:0042592,GO:0042593,GO:0042802,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045785,GO:0046203,GO:0048229,GO:0048518,GO:0048522,GO:0048856,GO:0048878,GO:0050670,GO:0050671,GO:0050789,GO:0050794,GO:0050863,GO:0050865,GO:0050867,GO:0050870,GO:0051171,GO:0051246,GO:0051249,GO:0051251,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051604,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070663,GO:0070665,GO:0071704,GO:0071840,GO:0080090,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1903037,GO:1903039,GO:2000112,GO:2000765	2.5.1.46,6.3.2.17	ko:K00809,ko:K01930,ko:K19721	ko00790,ko01100,ko01523,ko04974,map00790,map01100,map01523,map04974	-	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00536,ko01000	-	-	-	DS
YHH1_k127_4324077_2	293613.A1E_02110	4.617e-09	62.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,47EYI@766|Rickettsiales	766|Rickettsiales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
YHH1_k127_4336485_1	1265845.PWEIH_11990	6.666e-27	112.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H9KA@91061|Bacilli,26IZZ@186820|Listeriaceae	91061|Bacilli	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
YHH1_k127_4336485_0	1343739.PAP_07250	3.858e-28	119.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,242MG@183968|Thermococci	183968|Thermococci	F	nicotinamide-nucleotide adenylyltransferase activity	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
YHH1_k127_4418842_1	926569.ANT_18020	2.018e-65	235.0	COG0598@1|root,COG0598@2|Bacteria,2G6EQ@200795|Chloroflexi	200795|Chloroflexi	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
YHH1_k127_4418842_0	269797.Mbar_A2985	3.99e-71	252.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0668 Small-conductance mechanosensitive channel	mscS1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
YHH1_k127_4418842_2	243232.MJ_1476	8.428e-45	171.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23QQD@183939|Methanococci	183939|Methanococci	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
YHH1_k127_4479679_0	1042877.GQS_07225	6.306e-59	211.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
YHH1_k127_4479679_1	667014.Thein_2138	4.269e-57	208.0	COG0682@1|root,COG0682@2|Bacteria,2GGWB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
YHH1_k127_4655658_0	9305.ENSSHAP00000013859	2.191e-97	327.0	COG0143@1|root,COG0162@1|root,KOG2144@2759|Eukaryota,KOG2241@2759|Eukaryota,38E6V@33154|Opisthokonta,3BE3E@33208|Metazoa,3CXHC@33213|Bilateria,48133@7711|Chordata,495P0@7742|Vertebrata,3J4H5@40674|Mammalia,4JX8N@9263|Metatheria	33208|Metazoa	J	Tyrosyl-tRNA synthetase	YARS	GO:0000049,GO:0001664,GO:0002682,GO:0002685,GO:0002688,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004831,GO:0005102,GO:0005126,GO:0005153,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0006915,GO:0006935,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009605,GO:0009966,GO:0009987,GO:0010467,GO:0010469,GO:0010646,GO:0010758,GO:0012501,GO:0016070,GO:0016604,GO:0016874,GO:0016875,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0023051,GO:0030334,GO:0030545,GO:0031974,GO:0031981,GO:0032101,GO:0032879,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034660,GO:0040011,GO:0040012,GO:0042056,GO:0042221,GO:0042330,GO:0042379,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045236,GO:0046483,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050918,GO:0050920,GO:0051270,GO:0051716,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1905521,GO:2000145	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b,tRNA_bind
YHH1_k127_4655658_1	868131.MSWAN_1938	8.078e-20	97.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,23NTY@183925|Methanobacteria	183925|Methanobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
YHH1_k127_4660382_0	247490.KSU1_C0745	1.506e-56	206.0	COG0125@1|root,COG0125@2|Bacteria,2IZSW@203682|Planctomycetes	203682|Planctomycetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
YHH1_k127_4660382_1	56780.SYN_00357	6.072e-40	154.0	COG1351@1|root,COG1351@2|Bacteria,1QF4I@1224|Proteobacteria,43A0P@68525|delta/epsilon subdivisions,2X9Q1@28221|Deltaproteobacteria,2MSCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thymidylate synthase complementing protein	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
YHH1_k127_4680580_4	984892.SPSE_2004	0.0007743	49.0	COG0697@1|root,COG0697@2|Bacteria,1TRKD@1239|Firmicutes,4HA3N@91061|Bacilli,4GXKX@90964|Staphylococcaceae	91061|Bacilli	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH1_k127_4680580_1	697303.Thewi_0716	3.091e-27	120.0	COG0518@1|root,COG0518@2|Bacteria,1UAH0@1239|Firmicutes,24DR4@186801|Clostridia,42EZ6@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
YHH1_k127_4680580_3	1009370.ALO_13389	2.777e-12	79.0	COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4H4W3@909932|Negativicutes	909932|Negativicutes	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
YHH1_k127_4680580_2	110319.CF8_2538	2.715e-13	82.0	COG2170@1|root,COG2170@2|Bacteria,2GKCT@201174|Actinobacteria,4DNRR@85009|Propionibacteriales	201174|Actinobacteria	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
YHH1_k127_4680580_0	502025.Hoch_4185	1.513e-34	144.0	2DC8I@1|root,2ZD93@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_4684924_0	177437.HRM2_25970	3.865e-37	151.0	COG3271@1|root,COG3608@1|root,COG3271@2|Bacteria,COG3608@2|Bacteria,1QUH0@1224|Proteobacteria,43DZK@68525|delta/epsilon subdivisions,2X74A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
YHH1_k127_4696563_0	742743.HMPREF9453_02014	1.1e-58	206.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H2D7@909932|Negativicutes	909932|Negativicutes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
YHH1_k127_4696563_1	756067.MicvaDRAFT_3996	9.136e-21	102.0	COG0657@1|root,COG0657@2|Bacteria,1G1DJ@1117|Cyanobacteria,1H9E6@1150|Oscillatoriales	1117|Cyanobacteria	I	Protein of unknown function (DUF1460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460
YHH1_k127_4696563_2	399550.Smar_0844	2.064e-09	63.0	COG1890@1|root,arCOG04186@2157|Archaea,2XPNX@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
YHH1_k127_4711840_0	693661.Arcve_0985	1.013e-77	271.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
YHH1_k127_4711840_1	589924.Ferp_1137	5.957e-44	168.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,246QC@183980|Archaeoglobi	183980|Archaeoglobi	J	Forms part of the polypeptide exit tunnel	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
YHH1_k127_4840958_1	177437.HRM2_48760	1.001e-55	209.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2MKR7@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
YHH1_k127_4840958_4	1038869.AXAN01000112_gene2955	1.982e-05	56.0	COG1522@1|root,COG1522@2|Bacteria,1REAJ@1224|Proteobacteria,2VRWP@28216|Betaproteobacteria,1K307@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	-	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
YHH1_k127_4840958_3	644281.MFS40622_1754	2.981e-10	64.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23Q99@183939|Methanococci	183939|Methanococci	J	PFAM Diphthamide synthesis DPH2 protein	-	GO:0006417,GO:0006448,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:2000112,GO:2000765	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
YHH1_k127_4840958_2	332101.JIBU02000028_gene2697	6.713e-14	79.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24F4A@186801|Clostridia,36VI5@31979|Clostridiaceae	186801|Clostridia	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
YHH1_k127_4840958_0	391623.TERMP_00652	1.458e-121	402.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
YHH1_k127_491317_4	379066.GAU_2928	6.796e-06	55.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CW_binding_1,Flg_new,SLH
YHH1_k127_491317_1	573064.Mefer_0546	1.255e-32	133.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,23R23@183939|Methanococci	183939|Methanococci	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
YHH1_k127_491317_2	1220534.B655_2457	7.696e-16	82.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
YHH1_k127_491317_0	593117.TGAM_0130	1.257e-115	381.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
YHH1_k127_491317_3	439496.RBY4I_920	2.437e-07	56.0	2E0PH@1|root,31CM2@2|Bacteria,1P2BP@1224|Proteobacteria,2UUEG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_5021238_1	273116.14324627	7.371e-35	143.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,241Q6@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
YHH1_k127_5021238_4	419665.Maeo_0704	2.909e-06	51.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,23RB1@183939|Methanococci	183939|Methanococci	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
YHH1_k127_5021238_0	1041930.Mtc_1025	1.205e-42	166.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,2N93I@224756|Methanomicrobia	224756|Methanomicrobia	J	Translation initiation factor 2 alpha subunit	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
YHH1_k127_5021238_3	243232.MJ_0250	5.701e-18	84.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,23R97@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein S27E	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
YHH1_k127_5021238_2	395492.Rleg2_2066	9.369e-29	123.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria,2U73S@28211|Alphaproteobacteria,4BDZF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
YHH1_k127_5039464_1	580331.Thit_0656	1.421e-19	100.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,24870@186801|Clostridia,42GBI@68295|Thermoanaerobacterales	186801|Clostridia	M	TIGRFAM exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	2.7.8.6	ko:K00996	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
YHH1_k127_5039464_0	246194.CHY_0545	3.629e-60	212.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,42F5I@68295|Thermoanaerobacterales	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
YHH1_k127_505471_2	1391646.AVSU01000050_gene1655	4.464e-45	168.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia	186801|Clostridia	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
YHH1_k127_505471_6	345219.Bcoa_0464	4.793e-11	67.0	2E4D6@1|root,32Z8K@2|Bacteria,1VG1S@1239|Firmicutes,4HQ93@91061|Bacilli,1ZJK3@1386|Bacillus	91061|Bacilli	S	EamA-like transporter family	-	-	-	ko:K12962	ko01503,map01503	M00721	-	-	ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7.22	-	-	EamA
YHH1_k127_505471_5	195103.CPF_0236	1.945e-11	70.0	COG2076@1|root,COG2076@2|Bacteria,1VGPB@1239|Firmicutes,24S0F@186801|Clostridia,36KZS@31979|Clostridiaceae	186801|Clostridia	P	EamA-like transporter family	-	-	-	ko:K12962	ko01503,map01503	M00721	-	-	ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7.22	-	-	EamA
YHH1_k127_505471_3	1343739.PAP_03660	2.787e-26	125.0	COG5427@1|root,arCOG00563@2157|Archaea,2Y351@28890|Euryarchaeota,243KT@183968|Thermococci	183968|Thermococci	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
YHH1_k127_505471_0	269797.Mbar_A1804	1.029e-85	288.0	arCOG08210@1|root,arCOG08210@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_505471_1	1380600.AUYN01000001_gene2481	3.161e-47	173.0	COG0343@1|root,COG0343@2|Bacteria	2|Bacteria	F	queuine tRNA-ribosyltransferase activity	tgtC	-	-	-	-	-	-	-	-	-	-	-	TGT
YHH1_k127_505471_4	1244869.H261_13935	3.385e-20	94.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TUPK@28211|Alphaproteobacteria,2JPEX@204441|Rhodospirillales	204441|Rhodospirillales	C	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase	bchE	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
YHH1_k127_5072734_0	679926.Mpet_0580	3.371e-69	245.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
YHH1_k127_5072734_1	591019.Shell_0641	3.278e-10	67.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH1_k127_5096540_0	926550.CLDAP_34290	1.124e-32	142.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Big_3_2,Cadherin-like,Calx-beta,DUF11,DUF4347,DUF4430,DUF915,FTP,HYR,I-set,PQQ_2,PT-HINT,Peptidase_M36,Pro-kuma_activ,RHS_repeat,VCBS
YHH1_k127_5096540_1	439481.Aboo_1545	3.036e-06	50.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
YHH1_k127_529075_2	342949.PNA2_0051	0.0006314	45.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
YHH1_k127_529075_0	1343739.PAP_09980	8.287e-114	376.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota,2435F@183968|Thermococci	183968|Thermococci	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	kae1	GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
YHH1_k127_529075_1	932678.THERU_06730	0.0002006	48.0	COG3063@1|root,COG3063@2|Bacteria,2G55J@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
YHH1_k127_534419_0	1232410.KI421421_gene3684	1.757e-81	280.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,43UHD@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
YHH1_k127_534419_1	1232410.KI421421_gene3683	1.209e-40	160.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	ATP-grasp domain	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
YHH1_k127_5476791_2	402880.MmarC5_1308	1.878e-27	118.0	COG0438@1|root,arCOG01409@2157|Archaea,2Y6A0@28890|Euryarchaeota,23RT4@183939|Methanococci	183939|Methanococci	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
YHH1_k127_5476791_1	218140.BPSY_0135	6.501e-52	193.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4CZ73@85004|Bifidobacteriales	201174|Actinobacteria	U	Transport permease protein	tagG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
YHH1_k127_5476791_0	1047013.AQSP01000144_gene865	2.511e-92	320.0	COG1134@1|root,COG1134@2|Bacteria,2NP4S@2323|unclassified Bacteria	2|Bacteria	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
YHH1_k127_5541070_0	574087.Acear_0714	1.401e-105	362.0	COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia,3WAE7@53433|Halanaerobiales	186801|Clostridia	S	pfam abc1	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
YHH1_k127_5541070_1	756067.MicvaDRAFT_3720	1.476e-07	60.0	COG0546@1|root,COG0546@2|Bacteria,1G52P@1117|Cyanobacteria,1HB0I@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Haloacid dehalogenase-like hydrolase	cbbZp	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
YHH1_k127_562123_1	322710.Avin_11000	2.694e-36	145.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RN5Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	permease	VP2476	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
YHH1_k127_562123_0	634498.mru_2028	8.431e-68	242.0	COG0502@1|root,arCOG00659@2157|Archaea,2XU0K@28890|Euryarchaeota,23NQ9@183925|Methanobacteria	183925|Methanobacteria	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
YHH1_k127_562123_2	511680.BUTYVIB_02336	1.074e-08	62.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,249BI@186801|Clostridia	186801|Clostridia	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
YHH1_k127_5740602_1	579137.Metvu_1010	5.153e-24	104.0	COG2174@1|root,arCOG04168@2157|Archaea,2Y0IH@28890|Euryarchaeota,23R6M@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL34 family	rpl34e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
YHH1_k127_5740602_3	644281.MFS40622_1751	6.697e-08	63.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23QBG@183939|Methanococci	183939|Methanococci	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
YHH1_k127_5740602_0	1220534.B655_1489	4.719e-122	406.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,23NV1@183925|Methanobacteria	183925|Methanobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
YHH1_k127_5740602_2	693661.Arcve_0963	3.366e-10	65.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2471Q@183980|Archaeoglobi	183980|Archaeoglobi	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
YHH1_k127_5947842_0	1122179.KB890473_gene425	1.011e-17	98.0	COG3227@1|root,COG4935@1|root,COG3227@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M43,Reprolysin_4,Trypsin_2,fn3
YHH1_k127_5947842_1	264732.Moth_0241	5.284e-10	68.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Calx-beta,DUF11,DUF1573,F5_F8_type_C,FG-GAP,Glyco_hyd_101C,Glyco_hydro_101,NPCBM_assoc,SASA
YHH1_k127_597431_5	1292035.H476_0060	1.418e-36	142.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,25QFM@186804|Peptostreptococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
YHH1_k127_597431_4	573063.Metin_0333	1.883e-55	208.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,23QGQ@183939|Methanococci	183939|Methanococci	K	Fibronectin-binding A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
YHH1_k127_597431_2	933262.AXAM01000107_gene1503	6.376e-75	254.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,42QSH@68525|delta/epsilon subdivisions,2WP5X@28221|Deltaproteobacteria,2MJM5@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
YHH1_k127_597431_0	926550.CLDAP_08980	2.601e-161	515.0	COG0182@1|root,COG0182@2|Bacteria,2G5Z3@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
YHH1_k127_597431_1	1322246.BN4_10529	3.582e-105	347.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P5B@68525|delta/epsilon subdivisions,2WM02@28221|Deltaproteobacteria,2M7WB@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Purine nucleoside phosphorylase involved in purine salvage	mtap	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
YHH1_k127_597431_3	529709.PYCH_09980	1.863e-70	249.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,2438X@183968|Thermococci	183968|Thermococci	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
YHH1_k127_5979148_3	579137.Metvu_0229	2.198e-15	79.0	COG2888@1|root,arCOG01989@2157|Archaea,2XZS7@28890|Euryarchaeota,23R9I@183939|Methanococci	183939|Methanococci	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
YHH1_k127_5979148_2	380749.HY04AAS1_0647	2.091e-44	165.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
YHH1_k127_5979148_1	1408433.JHXV01000008_gene224	2.913e-86	297.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
YHH1_k127_5979148_0	697281.Mahau_1243	2.577e-223	707.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
YHH1_k127_6032189_0	742726.HMPREF9448_02566	1.275e-132	436.0	COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,2FN06@200643|Bacteroidia,22VUX@171551|Porphyromonadaceae	976|Bacteroidetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
YHH1_k127_6032189_1	272844.PAB0592	1.262e-64	229.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,243RC@183968|Thermococci	183968|Thermococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
YHH1_k127_6032189_3	402880.MmarC5_1795	1.222e-21	96.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,23R6Q@183939|Methanococci	183939|Methanococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
YHH1_k127_6032189_4	768679.TTX_1925	2.741e-13	71.0	COG1383@1|root,arCOG01885@2157|Archaea,2XRGM@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
YHH1_k127_6032189_2	1121422.AUMW01000012_gene2919	4.443e-22	104.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,260QU@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
YHH1_k127_6100830_1	1151117.AJLF01000001_gene1687	2.79e-12	70.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
YHH1_k127_6100830_5	573063.Metin_0502	0.0002316	45.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y26M@28890|Euryarchaeota,23RB9@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	zf-C2HC5
YHH1_k127_6100830_3	572546.Arcpr_1654	2.181e-11	68.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,246EF@183980|Archaeoglobi	183980|Archaeoglobi	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
YHH1_k127_6100830_4	573063.Metin_0422	3.329e-07	55.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,23R51@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
YHH1_k127_6100830_6	1331060.RLDS_16225	0.0002984	50.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2TR7U@28211|Alphaproteobacteria,2KCMN@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0668 Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
YHH1_k127_6100830_0	1094980.Mpsy_0422	7.182e-58	212.0	COG0034@1|root,COG0367@1|root,COG2102@1|root,arCOG00035@2157|Archaea,arCOG00071@2157|Archaea,arCOG00093@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
YHH1_k127_6100830_2	186497.PF0916	4.137e-12	74.0	COG3270@1|root,arCOG02285@2157|Archaea,2XZD7@28890|Euryarchaeota,24491@183968|Thermococci	183968|Thermococci	J	RNA-binding PUA-like domain of methyltransferase RsmF	-	-	-	-	-	-	-	-	-	-	-	-	Methyltranf_PUA
YHH1_k127_6107211_2	931277.C448_06980	3.452e-27	119.0	arCOG02703@1|root,arCOG02703@2157|Archaea,2XW3C@28890|Euryarchaeota,23UMF@183963|Halobacteria	183963|Halobacteria	Q	Methyltransferase type 11	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25,Methyltransf_31
YHH1_k127_6107211_3	70601.3258266	4.035e-06	51.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
YHH1_k127_6107211_0	604354.TSIB_0912	1.205e-101	338.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,243E1@183968|Thermococci	183968|Thermococci	L	AP endonuclease family 2	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
YHH1_k127_6107211_1	443143.GM18_3917	8.358e-86	296.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
YHH1_k127_6119515_0	1254432.SCE1572_33210	4.562e-108	367.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria,2Z1M7@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
YHH1_k127_6119515_2	1242864.D187_001262	4.561e-23	109.0	COG2890@1|root,COG2890@2|Bacteria	2|Bacteria	J	protein-(glutamine-N5) methyltransferase activity	rsmC	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	MTS
YHH1_k127_6119515_1	439235.Dalk_5142	3.176e-33	144.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MI4U@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
YHH1_k127_6121602_0	589924.Ferp_0913	1.776e-48	181.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,245UT@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
YHH1_k127_6121602_2	314230.DSM3645_26304	4.778e-15	85.0	COG0223@1|root,COG0223@2|Bacteria,2J4NR@203682|Planctomycetes	203682|Planctomycetes	J	Formyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
YHH1_k127_6121602_1	215803.DB30_1972	3.756e-20	101.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42VRI@68525|delta/epsilon subdivisions,2WRUV@28221|Deltaproteobacteria,2YVYN@29|Myxococcales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
YHH1_k127_6144050_3	591019.Shell_1550	1.339e-17	89.0	COG1813@1|root,arCOG01863@2157|Archaea,2XQXA@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
YHH1_k127_6144050_2	1196083.SALWKB12_0373	8.609e-19	99.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KPDK@206351|Neisseriales	206351|Neisseriales	L	Belongs to the methyltransferase superfamily	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
YHH1_k127_6144050_0	647113.Metok_1367	8.481e-40	159.0	COG0455@1|root,arCOG00589@2157|Archaea,2XT20@28890|Euryarchaeota,23QK5@183939|Methanococci	183939|Methanococci	D	Belongs to the ParA family	-	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	CbiA,ParA
YHH1_k127_6144050_1	386456.JQKN01000005_gene498	2.587e-24	106.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,23P5R@183925|Methanobacteria	183925|Methanobacteria	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
YHH1_k127_6144050_5	420247.Msm_1363	0.0001282	46.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y19U@28890|Euryarchaeota,23P99@183925|Methanobacteria	183925|Methanobacteria	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
YHH1_k127_6207033_0	589924.Ferp_0858	2.103e-102	347.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,245PE@183980|Archaeoglobi	183980|Archaeoglobi	K	histone acetyltransferase, ELP3 family	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
YHH1_k127_6207033_1	387631.Asulf_00376	1.233e-86	297.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,2462S@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	-	ko:K22446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
YHH1_k127_6207033_3	653733.Selin_1349	1.552e-48	180.0	COG4843@1|root,COG4843@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
YHH1_k127_6207033_2	572546.Arcpr_0982	1.95e-51	185.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,2465W@183980|Archaeoglobi	183980|Archaeoglobi	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
YHH1_k127_6207033_5	387631.Asulf_00699	3.006e-18	91.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2468I@183980|Archaeoglobi	183980|Archaeoglobi	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
YHH1_k127_6207033_6	415426.Hbut_1576	4.075e-07	55.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
YHH1_k127_6207033_4	186497.PF1562	6.67e-34	133.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,242U8@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
YHH1_k127_6211089_10	1192034.CAP_7489	1.048e-05	59.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4215,RCC1,RCC1_2
YHH1_k127_6211089_2	1047013.AQSP01000135_gene1562	4.621e-37	143.0	COG1963@1|root,COG1963@2|Bacteria,2NQ29@2323|unclassified Bacteria	2|Bacteria	S	Divergent PAP2 family	yuiD	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
YHH1_k127_6211089_5	1104324.P186_0139	5.778e-09	65.0	COG1372@1|root,arCOG03158@2157|Archaea	2157|Archaea	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	1.17.4.1	ko:K00525,ko:K03724	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3
YHH1_k127_6211089_3	1123373.ATXI01000020_gene1239	1.026e-36	147.0	COG0693@1|root,COG0693@2|Bacteria,2GGYK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
YHH1_k127_6211089_6	1121935.AQXX01000113_gene1403	1.685e-08	65.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,Pentapeptide
YHH1_k127_6211089_8	1220534.B655_1433	1.443e-07	61.0	COG0681@1|root,arCOG01739@2157|Archaea,2XYEA@28890|Euryarchaeota,23P1Z@183925|Methanobacteria	183925|Methanobacteria	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
YHH1_k127_6211089_0	1094980.Mpsy_1360	7.918e-82	279.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2NAKT@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH1_k127_6211089_4	192952.MM_2893	4.123e-21	107.0	COG1361@1|root,arCOG02079@2157|Archaea,2XTX8@28890|Euryarchaeota	28890|Euryarchaeota	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_6211089_1	402880.MmarC5_1135	3.119e-62	229.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23RIZ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH1_k127_6211089_9	573064.Mefer_0224	1.239e-06	52.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23QAJ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH1_k127_6217302_1	1191523.MROS_1828	6.438e-64	231.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
YHH1_k127_6217302_0	498742.BSPA14S_0585	4.194e-184	590.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
YHH1_k127_6217302_3	1392491.JIAE01000001_gene109	1.015e-23	111.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,2494W@186801|Clostridia,3WRED@541000|Ruminococcaceae	186801|Clostridia	Q	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH1_k127_6217302_2	342949.PNA2_0576	6.465e-57	204.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,24333@183968|Thermococci	183968|Thermococci	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
YHH1_k127_6284163_5	868131.MSWAN_1516	0.0005459	51.0	COG1287@1|root,arCOG02044@2157|Archaea,2XU59@28890|Euryarchaeota,23NKH@183925|Methanobacteria	183925|Methanobacteria	M	PFAM Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.21	ko:K21306	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	STT3
YHH1_k127_6284163_3	573064.Mefer_0760	3.09e-22	100.0	COG2456@1|root,arCOG05092@2157|Archaea,2XZCE@28890|Euryarchaeota,23R5T@183939|Methanococci	183939|Methanococci	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
YHH1_k127_6284163_2	1487923.DP73_04780	5.311e-27	124.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,2624P@186807|Peptococcaceae	186801|Clostridia	M	Glycosyl transferase 4-like	epsD	-	-	ko:K19422	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
YHH1_k127_6284163_1	760154.Sulba_2455	4.596e-33	142.0	COG0500@1|root,COG2835@1|root,COG0500@2|Bacteria,COG2835@2|Bacteria,1R0S1@1224|Proteobacteria,43D0F@68525|delta/epsilon subdivisions,2YS5S@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH1_k127_6284163_4	868131.MSWAN_1362	1.364e-15	91.0	COG0381@1|root,arCOG01392@2157|Archaea	2157|Archaea	M	UDP-N-acetylglucosamine 2-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_6284163_0	243232.MJ_1061	5.586e-90	304.0	COG1086@1|root,arCOG01375@2157|Archaea,2XV3Z@28890|Euryarchaeota,23Q9G@183939|Methanococci	183939|Methanococci	M	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_2
YHH1_k127_63726_2	420247.Msm_1053	4.214e-19	98.0	COG0517@1|root,arCOG00600@2157|Archaea,2Y88W@28890|Euryarchaeota,23NZQ@183925|Methanobacteria	183925|Methanobacteria	S	SMART Cystathionine beta-synthase, core	-	-	-	-	-	-	-	-	-	-	-	-	CBS
YHH1_k127_63726_0	523845.AQXV01000028_gene1046	5.965e-83	288.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,23Q5A@183939|Methanococci	183939|Methanococci	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
YHH1_k127_63726_3	1123274.KB899411_gene3072	3.75e-14	81.0	COG1378@1|root,COG1378@2|Bacteria	2|Bacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_63726_4	634498.mru_1361	1.098e-11	72.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,23P6T@183925|Methanobacteria	183925|Methanobacteria	J	RNA binding	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
YHH1_k127_63726_1	93059.P9211_11951	7.686e-20	94.0	2AMM7@1|root,31CH8@2|Bacteria,1GIN8@1117|Cyanobacteria,1MMG4@1212|Prochloraceae	1117|Cyanobacteria	L	Pyrimidine dimer DNA glycosylase	-	-	3.1.25.1	ko:K01161	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_excise
YHH1_k127_6402453_0	1041930.Mtc_0921	1.464e-69	252.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,2N9P9@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
YHH1_k127_6402453_3	1499967.BAYZ01000090_gene4941	2.068e-13	83.0	2DDA6@1|root,2ZH98@2|Bacteria	2|Bacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT
YHH1_k127_6402453_2	1094508.Tsac_1567	3.057e-37	156.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,42EZQ@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
YHH1_k127_6402453_1	1121423.JONT01000012_gene397	1.206e-41	170.0	COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,2481V@186801|Clostridia,261AV@186807|Peptococcaceae	186801|Clostridia	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
YHH1_k127_6441485_0	877455.Metbo_0458	3.285e-28	120.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,23NTY@183925|Methanobacteria	183925|Methanobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
YHH1_k127_6441485_1	404589.Anae109_2880	1.065e-12	78.0	COG4935@1|root,COG4935@2|Bacteria,1QZT5@1224|Proteobacteria,42YUM@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_6478163_0	697303.Thewi_1720	3.61e-221	709.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
YHH1_k127_6478163_1	309801.trd_1496	3.519e-07	58.0	COG1285@1|root,COG1285@2|Bacteria,2G77U@200795|Chloroflexi,27YGD@189775|Thermomicrobia	189775|Thermomicrobia	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
YHH1_k127_6482184_0	665571.STHERM_c03280	1.335e-72	258.0	COG0143@1|root,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
YHH1_k127_6517180_2	335541.Swol_0202	5.332e-05	45.0	COG0667@1|root,COG0667@2|Bacteria,1V40S@1239|Firmicutes,24HJ6@186801|Clostridia	186801|Clostridia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
YHH1_k127_6517180_0	909663.KI867150_gene1985	4.649e-165	530.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42NVU@68525|delta/epsilon subdivisions,2WMH6@28221|Deltaproteobacteria,2MRNF@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.111,5.4.3.8	ko:K01845,ko:K07257,ko:K21585	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272,R11607	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,CTP_transf_3
YHH1_k127_6517180_1	748449.Halha_2242	8.78e-76	270.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia	186801|Clostridia	M	synthase	pseI	-	2.5.1.56,2.5.1.97	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R09841	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
YHH1_k127_6538640_1	391623.TERMP_01727	2.613e-15	80.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
YHH1_k127_6538640_2	868131.MSWAN_2282	1.843e-11	69.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
YHH1_k127_6538640_0	523845.AQXV01000041_gene415	6.971e-41	156.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,23QUW@183939|Methanococci	183939|Methanococci	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
YHH1_k127_6750032_2	195522.BD01_2179	3.791e-19	90.0	arCOG03086@1|root,arCOG03086@2157|Archaea,2Y1GM@28890|Euryarchaeota,244HT@183968|Thermococci	183968|Thermococci	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
YHH1_k127_6750032_4	313624.NSP_17810	5.745e-11	66.0	COG1598@1|root,COG1598@2|Bacteria,1G9I4@1117|Cyanobacteria,1HPH2@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_6750032_0	304371.MCP_2248	1.035e-107	358.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
YHH1_k127_6750032_6	1380600.AUYN01000001_gene2869	0.0002172	54.0	COG3291@1|root,COG4412@1|root,COG4447@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria,COG4447@2|Bacteria,4NEZQ@976|Bacteroidetes,1HWS9@117743|Flavobacteriia	976|Bacteroidetes	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,PKD,Sortilin-Vps10,TSP_3
YHH1_k127_6750032_3	745718.JADT01000009_gene3030	2.802e-17	96.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,4NTFH@976|Bacteroidetes,1I4BS@117743|Flavobacteriia	976|Bacteroidetes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_6750032_5	1346330.M472_12165	3.752e-10	66.0	COG4818@1|root,COG4818@2|Bacteria,4NUVP@976|Bacteroidetes,1IUDX@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Chloroplast import component protein (Tic20)	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_6750032_1	1236689.MMALV_01400	4.499e-24	104.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,3F2SZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
YHH1_k127_6787736_2	1348583.ATLH01000013_gene2953	1.001e-10	72.0	COG1044@1|root,COG1044@2|Bacteria,4NP38@976|Bacteroidetes,1IIK2@117743|Flavobacteriia	976|Bacteroidetes	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_6787736_1	373903.Hore_14980	1.435e-53	196.0	COG1216@1|root,COG1216@2|Bacteria,1TS11@1239|Firmicutes,24BQ6@186801|Clostridia	186801|Clostridia	S	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721,ko:K00786	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
YHH1_k127_6787736_0	1379698.RBG1_1C00001G1319	2.454e-72	256.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
YHH1_k127_6836715_0	593750.Metfor_1086	1.592e-22	100.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
YHH1_k127_6836715_1	754027.HMPREF9554_01916	4.764e-05	52.0	COG0454@1|root,COG0456@2|Bacteria,2J8YX@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH1_k127_6905097_3	944479.JQLX01000011_gene738	1.892e-17	83.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	ko:K18106	ko00040,ko01100,map00040,map01100	M00630	R07676,R10565	RC00108	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
YHH1_k127_6905097_1	573064.Mefer_0526	3.615e-53	206.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVVS@28890|Euryarchaeota,23Q3M@183939|Methanococci	183939|Methanococci	S	Polysaccharide biosynthesis protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
YHH1_k127_6905097_2	323259.Mhun_3160	7.736e-19	92.0	COG0736@1|root,arCOG08267@2157|Archaea	2157|Archaea	I	transferase	-	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
YHH1_k127_6905097_0	436308.Nmar_0137	1.737e-145	469.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
YHH1_k127_6958712_1	391623.TERMP_01112	1.103e-43	165.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,243CC@183968|Thermococci	183968|Thermococci	D	Cell division protein 48 (CDC48) N-terminal domain	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
YHH1_k127_6958712_0	192952.MM_2556	5.826e-136	443.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,2N99K@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
YHH1_k127_695920_2	886293.Sinac_4338	1.693e-16	90.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
YHH1_k127_695920_1	1121335.Clst_0065	7.977e-48	181.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,3WGIE@541000|Ruminococcaceae	186801|Clostridia	GJM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hydrolase_like,NTP_transferase,PGM_PMM_I
YHH1_k127_695920_0	109871.XP_006674883.1	3.466e-51	189.0	COG0621@1|root,KOG4355@2759|Eukaryota,38HGF@33154|Opisthokonta,3Q33G@4751|Fungi	4751|Fungi	J	MiaB-like tRNA modifying enzyme, archaeal-type	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,TRAM,UPF0004
YHH1_k127_6984430_0	224325.AF_1299	2.22e-101	339.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
YHH1_k127_6984430_2	211165.AJLN01000070_gene5504	2.765e-20	93.0	COG4121@1|root,COG4121@2|Bacteria,1G0ZF@1117|Cyanobacteria,1JGZ3@1189|Stigonemataceae	1117|Cyanobacteria	S	S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_30
YHH1_k127_6984430_1	648996.Theam_1608	4.953e-25	108.0	COG4121@1|root,COG4121@2|Bacteria,2G42B@200783|Aquificae	200783|Aquificae	S	S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_30
YHH1_k127_6984430_3	1403313.AXBR01000023_gene2472	7.258e-05	52.0	COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,4HJUY@91061|Bacilli,1ZS0Q@1386|Bacillus	91061|Bacilli	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH1_k127_6994274_8	572544.Ilyop_0106	3.802e-15	76.0	COG0674@1|root,COG0674@2|Bacteria,3784H@32066|Fusobacteria	32066|Fusobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
YHH1_k127_6994274_1	574087.Acear_0037	5.097e-128	415.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,3WAIQ@53433|Halanaerobiales	186801|Clostridia	C	PFAM Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
YHH1_k127_6994274_0	679926.Mpet_1169	7.055e-144	482.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,2N9F3@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM CoA-binding domain protein	acdAB	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
YHH1_k127_6994274_2	1278311.AUAL01000001_gene138	2.738e-116	386.0	COG0282@1|root,COG0282@2|Bacteria,3WT18@544448|Tenericutes	544448|Tenericutes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
YHH1_k127_6994274_3	1031288.AXAA01000001_gene2260	1.693e-92	314.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,36DRX@31979|Clostridiaceae	186801|Clostridia	C	phosphate acetyltransferase	pta	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
YHH1_k127_6994274_4	56780.SYN_02222	5.152e-92	317.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42RHV@68525|delta/epsilon subdivisions,2WNH5@28221|Deltaproteobacteria,2MSJH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	hyhL	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
YHH1_k127_6994274_6	237368.SCABRO_02488	4.069e-54	200.0	COG1941@1|root,COG1941@2|Bacteria,2IXWB@203682|Planctomycetes	203682|Planctomycetes	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
YHH1_k127_6994274_5	1410661.JNKW01000001_gene866	7.317e-72	251.0	COG0543@1|root,COG0543@2|Bacteria,1TQBZ@1239|Firmicutes,248GQ@186801|Clostridia	186801|Clostridia	C	Sulfite reductase Subunit B	asrB	-	-	ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
YHH1_k127_6994274_7	742818.HMPREF9451_01061	2.664e-30	124.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria,4CUEB@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
YHH1_k127_7013290_0	1249634.D781_2493	1.914e-54	201.0	COG0535@1|root,COG0535@2|Bacteria,1N99K@1224|Proteobacteria	1224|Proteobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
YHH1_k127_7013290_1	186497.PF0217	1.168e-15	80.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,244C9@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
YHH1_k127_7013290_2	469604.HMPREF0946_00932	3.575e-05	53.0	COG0741@1|root,COG0741@2|Bacteria,37B1U@32066|Fusobacteria	32066|Fusobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
YHH1_k127_710337_0	439481.Aboo_1125	2.722e-85	294.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,3F2QZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Polyprenyl synthetase	idsA	GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
YHH1_k127_710337_1	1220534.B655_1741	8.305e-31	128.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23PS9@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
YHH1_k127_7173255_2	573063.Metin_0721	6.038e-44	167.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
YHH1_k127_7173255_1	523845.AQXV01000034_gene381	1.423e-56	205.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,23Q84@183939|Methanococci	183939|Methanococci	T	PFAM RIO-like kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
YHH1_k127_7173255_0	693661.Arcve_0273	3.781e-114	381.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,245WB@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
YHH1_k127_7173255_3	1385935.N836_04185	0.000447	42.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,VKOR
YHH1_k127_7182170_1	869213.JCM21142_72762	3.959e-122	401.0	COG1004@1|root,COG1004@2|Bacteria,4NE00@976|Bacteroidetes,47KAG@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
YHH1_k127_7182170_0	272562.CA_C2199	1.776e-165	539.0	COG3882@1|root,COG3882@2|Bacteria,1TTCC@1239|Firmicutes,24A4U@186801|Clostridia,36G4Q@31979|Clostridiaceae	186801|Clostridia	Q	HAD-superfamily phosphatase, subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	NIF
YHH1_k127_7182170_5	272562.CA_C2198	2.119e-13	72.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
YHH1_k127_7182170_4	796940.HMPREF9628_01280	8.457e-28	118.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia	186801|Clostridia	I	PFAM MaoC domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
YHH1_k127_7182170_3	457396.CSBG_02348	2.916e-37	150.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
YHH1_k127_7182170_2	272562.CA_C2197	3.276e-55	204.0	COG2746@1|root,COG2746@2|Bacteria,1V2QD@1239|Firmicutes,249QB@186801|Clostridia,36HXI@31979|Clostridiaceae	186801|Clostridia	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
YHH1_k127_7255023_0	399550.Smar_0797	6.922e-27	123.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPXH@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
YHH1_k127_7255023_1	251229.Chro_4434	6.712e-22	98.0	COG1917@1|root,COG1917@2|Bacteria,1G7QQ@1117|Cyanobacteria,3VJ18@52604|Pleurocapsales	1117|Cyanobacteria	C	PFAM Cupin domain	-	-	1.14.12.17	ko:K05916	ko05132,map05132	-	-	-	ko00000,ko00001,ko01000	-	-	-	Cupin_2,Globin
YHH1_k127_7255023_2	1026882.MAMP_03099	1.082e-15	83.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,462GE@72273|Thiotrichales	72273|Thiotrichales	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
YHH1_k127_7307909_3	470145.BACCOP_00718	0.0002743	47.0	COG0438@1|root,COG0438@2|Bacteria,4NE0W@976|Bacteroidetes,2FN8S@200643|Bacteroidia,4AMRQ@815|Bacteroidaceae	976|Bacteroidetes	M	Glycosyltransferase, group 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
YHH1_k127_7307909_0	530564.Psta_4683	2.547e-38	158.0	COG0707@1|root,COG0707@2|Bacteria,2IX27@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3
YHH1_k127_7307909_1	536227.CcarbDRAFT_0156	5.474e-08	59.0	COG1215@1|root,COG1215@2|Bacteria,1UFV7@1239|Firmicutes,24BR5@186801|Clostridia,36FKK@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF2064,Glycos_transf_2
YHH1_k127_7307909_2	573063.Metin_1432	1.082e-05	53.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23QBC@183939|Methanococci	183939|Methanococci	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
YHH1_k127_7346484_0	1122225.AULQ01000001_gene1443	5.714e-164	536.0	COG3387@1|root,COG3387@2|Bacteria,4NEE6@976|Bacteroidetes,1HY70@117743|Flavobacteriia	976|Bacteroidetes	G	COG3387 Glucoamylase and related glycosyl	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
YHH1_k127_7350325_2	391623.TERMP_02183	4.231e-18	92.0	COG0231@1|root,COG1499@1|root,arCOG04149@2157|Archaea,arCOG04277@2157|Archaea,2XUAI@28890|Euryarchaeota,242QZ@183968|Thermococci	183968|Thermococci	J	mRNA decay	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
YHH1_k127_7350325_0	1254432.SCE1572_18140	7.765e-79	282.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
YHH1_k127_7350325_1	589924.Ferp_1830	4.307e-20	103.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,245WA@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
YHH1_k127_745460_4	189425.PGRAT_29935	9.953e-05	48.0	COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,4IQQV@91061|Bacilli,26S77@186822|Paenibacillaceae	91061|Bacilli	M	UDP-N-acetylglucosamine 4,6-dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_2
YHH1_k127_745460_0	1094980.Mpsy_2365	1.204e-134	441.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,2NAHC@224756|Methanomicrobia	224756|Methanomicrobia	E	Beta-eliminating lyase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
YHH1_k127_745460_2	523845.AQXV01000055_gene147	9.18e-116	381.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23QBX@183939|Methanococci	183939|Methanococci	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
YHH1_k127_745460_1	398512.JQKC01000006_gene693	1.138e-133	437.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia,3WI84@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
YHH1_k127_745460_3	694431.DESACE_04230	1.05e-14	81.0	COG3980@1|root,COG3980@2|Bacteria,1Q330@1224|Proteobacteria,43470@68525|delta/epsilon subdivisions,2WS42@28221|Deltaproteobacteria,2M7HZ@213113|Desulfurellales	28221|Deltaproteobacteria	M	COG3980 Spore coat polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
YHH1_k127_7468098_7	517418.Ctha_1623	5.855e-09	66.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
YHH1_k127_7468098_3	1196028.ALEF01000042_gene697	3.305e-34	145.0	COG0814@1|root,COG0814@2|Bacteria,1UTY5@1239|Firmicutes,4HT80@91061|Bacilli	91061|Bacilli	E	Transmembrane amino acid transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
YHH1_k127_7468098_0	1151117.AJLF01000001_gene966	5.869e-87	298.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,242ZU@183968|Thermococci	183968|Thermococci	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
YHH1_k127_7468098_2	1042877.GQS_08490	1.112e-37	151.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,243N3@183968|Thermococci	183968|Thermococci	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
YHH1_k127_7468098_1	387631.Asulf_00693	3.398e-59	216.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,245Q7@183980|Archaeoglobi	183980|Archaeoglobi	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
YHH1_k127_7468098_5	1005999.GLGR_1663	4.189e-21	102.0	COG0730@1|root,COG0730@2|Bacteria,1PE0G@1224|Proteobacteria,1S0EW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
YHH1_k127_7468098_6	693661.Arcve_1227	3.998e-09	60.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,247AX@183980|Archaeoglobi	183980|Archaeoglobi	L	Centromere kinetochore component CENP-T histone fold	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
YHH1_k127_7468098_4	589924.Ferp_1640	2.418e-29	122.0	COG1591@1|root,arCOG00919@2157|Archaea,2XTHF@28890|Euryarchaeota,246ED@183980|Archaeoglobi	183980|Archaeoglobi	L	A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products	hjc	-	3.1.22.4	ko:K03552	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Hjc
YHH1_k127_7630655_0	697281.Mahau_1713	7.117e-220	711.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,42ER6@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
YHH1_k127_7630655_4	526218.Sterm_1982	2.965e-06	57.0	COG1378@1|root,COG1378@2|Bacteria,379AB@32066|Fusobacteria	32066|Fusobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
YHH1_k127_7630655_3	1410653.JHVC01000001_gene1408	1.459e-08	61.0	2ENWS@1|root,33GHQ@2|Bacteria,1VQNU@1239|Firmicutes,24TC6@186801|Clostridia,36T5H@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_7630655_2	1163730.FFONT_0460	2.993e-20	91.0	COG1644@1|root,arCOG04244@2157|Archaea,2XR60@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
YHH1_k127_7630655_1	387631.Asulf_00630	1.473e-30	124.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2471N@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
YHH1_k127_7800216_0	693661.Arcve_0650	8.931e-86	287.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
YHH1_k127_7800216_4	1403819.BATR01000059_gene1822	5.22e-09	61.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	5.3.3.19	ko:K19547	ko01130,map01130	M00787	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,HATPase_c,His_kinase,PocR
YHH1_k127_7800216_1	351160.RCIX1592	4.375e-59	210.0	COG2033@1|root,arCOG02146@2157|Archaea,2Y059@28890|Euryarchaeota,2NB06@224756|Methanomicrobia	224756|Methanomicrobia	C	Desulfoferrodoxin, N-terminal domain	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
YHH1_k127_7800216_5	521011.Mpal_1476	2.479e-08	57.0	arCOG12591@1|root,arCOG12591@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_7800216_2	1462527.CCDM010000006_gene4499	8.588e-47	177.0	COG1018@1|root,COG1018@2|Bacteria,1TVUR@1239|Firmicutes,4HQ9B@91061|Bacilli	91061|Bacilli	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_1
YHH1_k127_7800216_3	579137.Metvu_0632	1.559e-18	88.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota	28890|Euryarchaeota	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
YHH1_k127_7838108_1	563192.HMPREF0179_03201	9.452e-167	534.0	COG1449@1|root,COG1449@2|Bacteria,1R8JX@1224|Proteobacteria,42QA5@68525|delta/epsilon subdivisions,2WMM5@28221|Deltaproteobacteria,2M9GJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
YHH1_k127_7838108_2	1041607.K0KY16	9.716e-120	407.0	COG0438@1|root,KOG3742@2759|Eukaryota,38BSH@33154|Opisthokonta,3NU8X@4751|Fungi,3QNRC@4890|Ascomycota,3RT7Z@4891|Saccharomycetes	4751|Fungi	H	Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan	GSY1	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.11	ko:K00693	ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3	-	Glycogen_syn
YHH1_k127_7838108_3	693661.Arcve_1224	2.455e-93	317.0	COG1085@1|root,arCOG00420@2157|Archaea,2Y3A2@28890|Euryarchaeota	28890|Euryarchaeota	C	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_7838108_0	1116472.MGMO_71c00060	4.04e-245	782.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEIG@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.2,3.6.3.6	ko:K01531,ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
YHH1_k127_7838108_4	316274.Haur_1221	1.162e-13	72.0	COG1208@1|root,COG1208@2|Bacteria,2G5KH@200795|Chloroflexi,375AA@32061|Chloroflexia	32061|Chloroflexia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
YHH1_k127_7918910_1	1463934.JOCF01000035_gene2456	1.721e-14	79.0	COG0500@1|root,COG2226@2|Bacteria,2I3BB@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH1_k127_7918910_0	386456.JQKN01000007_gene3332	2.286e-28	119.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,23PNK@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Mov34 MPN PAD-1	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
YHH1_k127_7918910_2	351160.RRC381	4.452e-08	56.0	COG4277@1|root,arCOG00661@2157|Archaea,2XWFQ@28890|Euryarchaeota,2NA7U@224756|Methanomicrobia	224756|Methanomicrobia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
YHH1_k127_7950188_0	1265505.ATUG01000001_gene3769	7.428e-104	352.0	COG0458@1|root,COG0458@2|Bacteria,1RFH4@1224|Proteobacteria,42NQ6@68525|delta/epsilon subdivisions,2WMDW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EF	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4,GARS_A
YHH1_k127_7950188_2	944481.JAFP01000001_gene149	5.658e-73	256.0	COG1449@1|root,COG1449@2|Bacteria,1R51R@1224|Proteobacteria,42P4W@68525|delta/epsilon subdivisions,2WK2R@28221|Deltaproteobacteria,2M6UE@213113|Desulfurellales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
YHH1_k127_7950188_1	909663.KI867150_gene1973	2.792e-74	256.0	COG1449@1|root,COG1449@2|Bacteria,1R51R@1224|Proteobacteria,42P4W@68525|delta/epsilon subdivisions,2WK2R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
YHH1_k127_7952506_0	877455.Metbo_0954	1.337e-67	251.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,23NSV@183925|Methanobacteria	183925|Methanobacteria	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
YHH1_k127_7952506_1	456442.Mboo_1796	1.399e-35	143.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,2N9GN@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
YHH1_k127_7954504_1	1333523.L593_10120	8.435e-18	87.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,23S15@183963|Halobacteria	183963|Halobacteria	J	exosome subunit	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
YHH1_k127_7954504_0	644281.MFS40622_1571	8.674e-68	238.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23QEI@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
YHH1_k127_7954504_2	604354.TSIB_1353	3.129e-10	65.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2445Q@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
YHH1_k127_7957173_1	1449342.JQMR01000001_gene783	2.738e-06	50.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli	91061|Bacilli	K	Cold-Shock Protein	cspC	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
YHH1_k127_7957173_0	1499967.BAYZ01000179_gene4626	3.986e-138	453.0	COG2414@1|root,COG2414@2|Bacteria	2|Bacteria	C	aldehyde ferredoxin oxidoreductase activity	-	-	1.2.7.5,1.2.7.6	ko:K03738,ko:K11389	ko00010,ko00030,ko01100,ko01120,ko01200,ko01230,map00010,map00030,map01100,map01120,map01200,map01230	M00001,M00002,M00309	R07159,R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH1_k127_8083924_0	1151117.AJLF01000001_gene1200	2.548e-71	256.0	COG2100@1|root,arCOG00951@2157|Archaea,2XU1G@28890|Euryarchaeota,2439D@183968|Thermococci	183968|Thermococci	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06935	-	-	-	-	ko00000	-	-	-	Radical_SAM
YHH1_k127_8135750_0	1120968.AUBX01000011_gene3306	5.501e-111	372.0	COG0297@1|root,COG0297@2|Bacteria,4PKP8@976|Bacteroidetes,47JA2@768503|Cytophagia	976|Bacteroidetes	G	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
YHH1_k127_8206480_0	269799.Gmet_1071	2.207e-105	349.0	COG3617@1|root,COG3617@2|Bacteria,1QX1C@1224|Proteobacteria,42R8T@68525|delta/epsilon subdivisions,2WQ1T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	BRO family, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bro-N
YHH1_k127_8206480_1	1123248.KB893316_gene4600	4.797e-07	61.0	COG1749@1|root,COG3055@1|root,COG1749@2|Bacteria,COG3055@2|Bacteria,4NTUT@976|Bacteroidetes	976|Bacteroidetes	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4082
YHH1_k127_8223429_1	269797.Mbar_A0890	3.859e-30	127.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
YHH1_k127_8223429_0	269797.Mbar_A2805	1.796e-193	615.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,2N9BE@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
YHH1_k127_8240744_4	1183377.Py04_1513	2.58e-05	54.0	COG1300@1|root,arCOG01994@2157|Archaea,2XY6M@28890|Euryarchaeota,24467@183968|Thermococci	183968|Thermococci	S	Stage II sporulation protein M	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
YHH1_k127_8240744_2	243232.MJ_1654	1.575e-12	76.0	arCOG02261@1|root,arCOG02261@2157|Archaea,2XWQZ@28890|Euryarchaeota,23QUF@183939|Methanococci	183939|Methanococci	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH1_k127_8240744_0	565033.GACE_0237	4.978e-161	529.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,246MK@183980|Archaeoglobi	183980|Archaeoglobi	L	Mcm family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_OB
YHH1_k127_8240744_1	573063.Metin_0817	1.266e-50	187.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,23Q47@183939|Methanococci	183939|Methanococci	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
YHH1_k127_8240744_3	1219084.AP014508_gene1732	1.655e-11	67.0	COG1355@1|root,COG1355@2|Bacteria,2GCU7@200918|Thermotogae	200918|Thermotogae	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
YHH1_k127_8248838_4	1236518.BAKP01000041_gene2146	0.0001056	46.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
YHH1_k127_8248838_1	604354.TSIB_1461	5.206e-53	199.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
YHH1_k127_8248838_3	565034.BHWA1_02432	4.137e-12	74.0	COG2039@1|root,COG2039@2|Bacteria,2J70U@203691|Spirochaetes	203691|Spirochaetes	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
YHH1_k127_8248838_2	1506994.JNLQ01000002_gene2932	2.264e-18	91.0	COG0537@1|root,COG0537@2|Bacteria,1VZUA@1239|Firmicutes,24PED@186801|Clostridia,4BXV1@830|Butyrivibrio	186801|Clostridia	FG	adenosine 5'-monophosphoramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_8248838_0	768672.Desfe_1369	2.275e-66	230.0	COG1222@1|root,arCOG01306@2157|Archaea,2XPT7@28889|Crenarchaeota	28889|Crenarchaeota	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
YHH1_k127_8271499_0	469382.Hbor_19720	1.785e-127	437.0	arCOG02907@1|root,arCOG02907@2157|Archaea,2XVFW@28890|Euryarchaeota,23TI1@183963|Halobacteria	183963|Halobacteria	S	Von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
YHH1_k127_8271499_2	1238425.J07HQW2_03291	2.16e-60	231.0	arCOG02905@1|root,arCOG02905@2157|Archaea,2XU82@28890|Euryarchaeota,23STF@183963|Halobacteria	183963|Halobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
YHH1_k127_8271499_4	1131266.ARWQ01000009_gene964	3.024e-47	181.0	COG1940@1|root,arCOG04280@2157|Archaea,41SWX@651137|Thaumarchaeota	651137|Thaumarchaeota	K	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
YHH1_k127_8271499_3	373903.Hore_18020	1.381e-52	198.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3WABY@53433|Halanaerobiales	186801|Clostridia	G	fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
YHH1_k127_8271499_1	386456.JQKN01000008_gene1390	8.208e-66	239.0	COG0420@1|root,arCOG00397@2157|Archaea,2XWH1@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
YHH1_k127_828315_1	204536.SULAZ_0257	6.493e-05	48.0	COG0125@1|root,COG0125@2|Bacteria,2G3YA@200783|Aquificae	200783|Aquificae	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
YHH1_k127_828315_0	195522.BD01_1813	4.032e-22	104.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,243FW@183968|Thermococci	183968|Thermococci	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
YHH1_k127_8335301_0	1201288.M900_1245	6.341e-15	89.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,42PTT@68525|delta/epsilon subdivisions,2MT5U@213481|Bdellovibrionales,2WS13@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Zn_pept	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14
YHH1_k127_8335301_1	448385.sce0987	2.526e-14	87.0	COG1520@1|root,COG4932@1|root,COG5624@1|root,COG1520@2|Bacteria,COG4932@2|Bacteria,COG5624@2|Bacteria,1QUEG@1224|Proteobacteria,42YJZ@68525|delta/epsilon subdivisions,2WWPU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KM	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B,TGFb_propeptide
YHH1_k127_8335301_2	1457250.BBMO01000002_gene2072	0.0006263	50.0	COG1520@1|root,arCOG02556@2157|Archaea,2XW47@28890|Euryarchaeota,23U0N@183963|Halobacteria	183963|Halobacteria	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
YHH1_k127_8370389_0	368407.Memar_2225	2.535e-66	233.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,2N9U4@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
YHH1_k127_8370389_1	634498.mru_0238	8.147e-08	61.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23PMM@183925|Methanobacteria	183925|Methanobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_8370389_2	1343739.PAP_06240	0.0001721	53.0	COG1196@1|root,arCOG00371@2157|Archaea,2Y3V4@28890|Euryarchaeota,24429@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_8376266_0	237368.SCABRO_03724	2.733e-177	570.0	COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
YHH1_k127_8376266_1	404589.Anae109_2770	3.478e-106	355.0	COG1697@1|root,COG1697@2|Bacteria,1NBFJ@1224|Proteobacteria,4314R@68525|delta/epsilon subdivisions,2WWNC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA topoisomerase VI subunit A	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
YHH1_k127_8376266_2	999411.HMPREF1092_00547	0.0003153	51.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,36DX7@31979|Clostridiaceae	186801|Clostridia	S	PHP domain	trpH	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
YHH1_k127_8426146_1	156889.Mmc1_1094	7.081e-05	56.0	COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
YHH1_k127_8426146_0	344747.PM8797T_02424	2.113e-10	75.0	COG1404@1|root,COG2931@1|root,COG3209@1|root,COG3210@1|root,COG4932@1|root,COG5276@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	M	domain protein	-	-	3.2.1.4,3.4.21.62,3.4.24.40	ko:K01179,ko:K01342,ko:K01406,ko:K07004,ko:K12287,ko:K14194,ko:K15125,ko:K20276	ko00500,ko01100,ko01503,ko02024,ko05133,ko05150,map00500,map01100,map01503,map02024,map05133,map05150	-	R06200,R11307,R11308	-	ko00000,ko00001,ko00536,ko01000,ko01002,ko02044,ko03110	-	GH5,GH9	-	Calx-beta,Exo_endo_phos,HemolysinCabind,VCBS
YHH1_k127_8587441_0	857293.CAAU_0443	7.065e-12	74.0	COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,24AD6@186801|Clostridia,36FJ2@31979|Clostridiaceae	186801|Clostridia	S	reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2,SCP2
YHH1_k127_8587441_2	240015.ACP_0163	2.139e-10	70.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria,2JHKB@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_8587441_1	748449.Halha_1291	1.176e-10	72.0	COG1075@1|root,COG1075@2|Bacteria,1URR6@1239|Firmicutes,259N3@186801|Clostridia,3WB3G@53433|Halanaerobiales	186801|Clostridia	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
YHH1_k127_8587441_3	1047013.AQSP01000130_gene1853	6.709e-07	55.0	COG2887@1|root,COG2887@2|Bacteria,2NQTZ@2323|unclassified Bacteria	2|Bacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	FtsK_SpoIIIE,PDDEXK_1
YHH1_k127_859212_1	1121101.HMPREF1532_02758	1.228e-11	76.0	COG0392@1|root,COG0392@2|Bacteria,4NM19@976|Bacteroidetes,2FN35@200643|Bacteroidia,4AKQC@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
YHH1_k127_859212_3	1537994.JQFW01000057_gene488	0.0006609	49.0	COG0558@1|root,COG0558@2|Bacteria,1RD5Y@1224|Proteobacteria,1RZ4Q@1236|Gammaproteobacteria,466ED@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	ynjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
YHH1_k127_859212_2	1121459.AQXE01000017_gene2118	3.305e-07	61.0	2BICI@1|root,32CIM@2|Bacteria,1R1BV@1224|Proteobacteria,43D8J@68525|delta/epsilon subdivisions,2X8F6@28221|Deltaproteobacteria,2MAMC@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_859212_0	406327.Mevan_1000	6.463e-26	113.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,23QZ6@183939|Methanococci	183939|Methanococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
YHH1_k127_8619927_0	573064.Mefer_1171	3.392e-59	213.0	COG2231@1|root,arCOG00461@2157|Archaea,2Y86S@28890|Euryarchaeota,23R2Z@183939|Methanococci	183939|Methanococci	L	PFAM HhH-GPD family protein	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
YHH1_k127_8619927_1	565033.GACE_2148	4.446e-23	102.0	COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota,246ZF@183980|Archaeoglobi	183980|Archaeoglobi	P	PFAM zinc iron permease	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
YHH1_k127_8682607_1	304371.MCP_2247	1.663e-19	96.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,2N9PR@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
YHH1_k127_8682607_0	589924.Ferp_0683	4.745e-24	111.0	COG2512@1|root,arCOG00377@2157|Archaea,2XY2E@28890|Euryarchaeota,246A4@183980|Archaeoglobi	183980|Archaeoglobi	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH1_k127_8758360_2	273057.SSO0743	2.981e-66	229.0	COG0012@1|root,arCOG00357@2157|Archaea,2XPTY@28889|Crenarchaeota	28889|Crenarchaeota	J	GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
YHH1_k127_8758360_3	1459636.NTE_01071	7.745e-25	111.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_8758360_5	1459636.NTE_01071	2.104e-06	50.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_8758360_1	647113.Metok_1389	2.45e-81	286.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,23Q03@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
YHH1_k127_8758360_4	1196031.ALEG01000048_gene4738	1.468e-19	102.0	COG0591@1|root,COG0591@2|Bacteria,1U5X8@1239|Firmicutes,4IRPR@91061|Bacilli,1ZRWH@1386|Bacillus	91061|Bacilli	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
YHH1_k127_8758360_0	351160.RCIX1267	1.526e-106	364.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
YHH1_k127_8758360_6	1492737.FEM08_28680	0.0005538	45.0	COG3402@1|root,COG3402@2|Bacteria,4NUVJ@976|Bacteroidetes,1I2NQ@117743|Flavobacteriia,2NW6K@237|Flavobacterium	976|Bacteroidetes	S	Bacterial PH domain	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
YHH1_k127_8760573_2	867903.ThesuDRAFT_00381	6.43e-67	237.0	COG1260@1|root,COG1260@2|Bacteria,1UY87@1239|Firmicutes,24C5P@186801|Clostridia	186801|Clostridia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
YHH1_k127_8760573_4	403833.Pmob_0586	1.574e-29	121.0	COG1144@1|root,COG1144@2|Bacteria,2GD79@200918|Thermotogae	200918|Thermotogae	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
YHH1_k127_8760573_3	381764.Fnod_0866	6.051e-54	195.0	COG1014@1|root,COG1014@2|Bacteria,2GCTI@200918|Thermotogae	200918|Thermotogae	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
YHH1_k127_8760573_0	1173024.KI912148_gene4133	7.81e-198	629.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1G0GP@1117|Cyanobacteria,1JJBI@1189|Stigonemataceae	1117|Cyanobacteria	G	PEP-utilising enzyme, TIM barrel domain	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	Intein_splicing,PEP-utilizers,PEP-utilizers_C,PPDK_N
YHH1_k127_8760573_1	525897.Dbac_0212	4.06e-126	408.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2MARD@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
YHH1_k127_8760573_10	1232443.BAIA02000155_gene1762	9.008e-07	53.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,268J6@186813|unclassified Clostridiales	186801|Clostridia	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
YHH1_k127_8760573_5	5911.EAR83789	1.855e-24	116.0	2D63N@1|root,2T0KT@2759|Eukaryota,3ZCNN@5878|Ciliophora	5878|Ciliophora	S	Kazal-type proteinase inhibitor 1	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_8760573_6	70601.3257406	5.177e-23	102.0	COG1324@1|root,arCOG04231@2157|Archaea,2XYPN@28890|Euryarchaeota,244AK@183968|Thermococci	183968|Thermococci	P	CutA1 divalent ion tolerance protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
YHH1_k127_8760573_7	351160.RCIX1274	1.054e-20	101.0	COG0640@1|root,arCOG01686@2157|Archaea,2XX9R@28890|Euryarchaeota,2N9WK@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
YHH1_k127_8760573_8	756883.Halar_2532	1.154e-20	97.0	COG5378@1|root,arCOG02121@2157|Archaea	2157|Archaea	S	PFAM Nucleotide-binding protein, PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_2
YHH1_k127_8827228_2	1027292.HMPREF9372_1223	1.323e-06	60.0	COG1511@1|root,COG1511@2|Bacteria,1TQ15@1239|Firmicutes,4H9T9@91061|Bacilli	91061|Bacilli	V	domain protein	-	-	-	ko:K01421	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,DUF3533
YHH1_k127_8827228_1	545697.HMPREF0216_00099	1.043e-50	188.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH1_k127_8827228_0	1047013.AQSP01000139_gene2394	7.277e-90	301.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
YHH1_k127_8869398_0	70601.3258051	4.314e-140	465.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,242VY@183968|Thermococci	183968|Thermococci	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
YHH1_k127_8881066_0	439481.Aboo_0846	2.644e-136	446.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,3F37W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	class II (D K and N)	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
YHH1_k127_8881066_2	1229205.BUPH_06540	2.228e-09	68.0	COG1522@1|root,COG1522@2|Bacteria,1RH5M@1224|Proteobacteria,2VVFY@28216|Betaproteobacteria,1KBQW@119060|Burkholderiaceae	28216|Betaproteobacteria	K	AsnC-type helix-turn-helix domain	-	-	-	ko:K15782	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
YHH1_k127_8881066_1	700598.Niako_1310	3.218e-79	280.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
YHH1_k127_8930191_0	269799.Gmet_1071	7.708e-101	335.0	COG3617@1|root,COG3617@2|Bacteria,1QX1C@1224|Proteobacteria,42R8T@68525|delta/epsilon subdivisions,2WQ1T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	BRO family, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bro-N
YHH1_k127_8930191_1	1151117.AJLF01000001_gene1687	2.11e-14	77.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
YHH1_k127_8946975_0	351160.RCIX939	2.272e-180	589.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
YHH1_k127_8951307_3	1365176.N186_02105	2.064e-08	58.0	COG2147@1|root,arCOG04089@2157|Archaea,2XQXG@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
YHH1_k127_8951307_1	572546.Arcpr_1342	2.706e-42	163.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2463G@183980|Archaeoglobi	183980|Archaeoglobi	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
YHH1_k127_8951307_0	573064.Mefer_0676	1.439e-60	220.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,23QAX@183939|Methanococci	183939|Methanococci	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
YHH1_k127_8951307_2	573064.Mefer_0675	2.26e-27	117.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,23QSP@183939|Methanococci	183939|Methanococci	J	PFAM ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
YHH1_k127_8951307_4	529709.PYCH_01600	0.0001621	46.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,243K6@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
YHH1_k127_8956116_0	886377.Murru_0616	2.301e-24	115.0	COG2017@1|root,COG2017@2|Bacteria,4NHSZ@976|Bacteroidetes,1I00K@117743|Flavobacteriia	976|Bacteroidetes	G	Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
YHH1_k127_8962089_1	456442.Mboo_0404	1.401e-14	76.0	arCOG11378@1|root,arCOG11378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_8962089_0	768706.Desor_2210	2.031e-51	192.0	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,26128@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
YHH1_k127_8975985_1	3712.Bo3g013300.1	0.0004192	53.0	KOG0597@1|root,KOG0597@2759|Eukaryota,37I7E@33090|Viridiplantae,3GA0E@35493|Streptophyta,3HRJI@3699|Brassicales	35493|Streptophyta	T	ATP binding binding kinase protein kinase protein serine threonine kinase	-	GO:0000003,GO:0000226,GO:0000278,GO:0000281,GO:0000910,GO:0000911,GO:0000912,GO:0000914,GO:0001932,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005819,GO:0005856,GO:0005911,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007275,GO:0007349,GO:0007399,GO:0008017,GO:0008092,GO:0008150,GO:0009506,GO:0009524,GO:0009555,GO:0009556,GO:0009574,GO:0009653,GO:0009966,GO:0009987,GO:0010245,GO:0010342,GO:0010646,GO:0010975,GO:0015630,GO:0015631,GO:0016043,GO:0019220,GO:0019222,GO:0019953,GO:0022008,GO:0022402,GO:0022414,GO:0022607,GO:0023051,GO:0030054,GO:0030154,GO:0030334,GO:0031323,GO:0031344,GO:0031399,GO:0032268,GO:0032501,GO:0032502,GO:0032506,GO:0032872,GO:0032879,GO:0034293,GO:0040012,GO:0042325,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043408,GO:0043934,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045595,GO:0045664,GO:0046328,GO:0048229,GO:0048236,GO:0048583,GO:0048646,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051171,GO:0051174,GO:0051239,GO:0051246,GO:0051270,GO:0051301,GO:0051321,GO:0051704,GO:0051960,GO:0055044,GO:0060255,GO:0060284,GO:0061640,GO:0065007,GO:0070302,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0090036,GO:0120035,GO:1900744,GO:1902407,GO:1902410,GO:1902531,GO:1903046,GO:1903047,GO:2000026,GO:2000145,GO:2001222	2.7.11.1	ko:K17545	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
YHH1_k127_8975985_0	1293054.HSACCH_01400	1.708e-14	87.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WAHY@53433|Halanaerobiales	186801|Clostridia	T	Protein kinase domain	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
YHH1_k127_8987297_0	523850.TON_0714	1.856e-169	545.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
YHH1_k127_8987297_1	485913.Krac_10545	4.187e-58	209.0	COG0528@1|root,COG0528@2|Bacteria	2|Bacteria	F	UMP kinase activity	mosB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914	2.7.4.22	ko:K00947,ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
YHH1_k127_8987297_2	411490.ANACAC_03069	1.389e-06	53.0	COG1716@1|root,COG1716@2|Bacteria,1VM2C@1239|Firmicutes,24WE7@186801|Clostridia	186801|Clostridia	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
YHH1_k127_8995490_0	1408422.JHYF01000008_gene3569	2.186e-54	203.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH1_k127_8995490_1	186497.PF0544	5.767e-34	138.0	COG0432@1|root,arCOG04214@2157|Archaea,2XXSW@28890|Euryarchaeota,2449A@183968|Thermococci	183968|Thermococci	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
YHH1_k127_8995589_0	997296.PB1_02290	1.633e-33	148.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,4HA66@91061|Bacilli,1ZBB0@1386|Bacillus	91061|Bacilli	E	amino acid	-	-	-	ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13	-	-	AA_permease,AA_permease_2
YHH1_k127_8995589_1	1054217.TALC_00446	5.628e-14	76.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,241PJ@183967|Thermoplasmata	183967|Thermoplasmata	J	Putative diphthamide synthesis protein	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
YHH1_k127_9008423_0	391623.TERMP_00910	3.662e-221	702.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,245CQ@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
YHH1_k127_9008423_2	5145.XP_001906550.1	1.939e-22	113.0	2E0M6@1|root,2S819@2759|Eukaryota,3AAYK@33154|Opisthokonta,3PND8@4751|Fungi,3R7JH@4890|Ascomycota,21EE6@147550|Sordariomycetes,3UAE7@5139|Sordariales	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_9008423_3	55529.EKX48264	0.0001005	55.0	COG0515@1|root,KOG1187@2759|Eukaryota	2759|Eukaryota	KLT	protein serine/threonine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GUB_WAK_bind,WAK_assoc
YHH1_k127_9008423_1	368407.Memar_1634	3.845e-32	127.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
YHH1_k127_9014405_3	1220534.B655_1477	3.799e-37	144.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,23NZ9@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
YHH1_k127_9014405_0	342949.PNA2_0222	6.79e-49	177.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,243ZQ@183968|Thermococci	183968|Thermococci	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
YHH1_k127_9014405_2	579137.Metvu_1636	1.439e-40	158.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,23QG3@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
YHH1_k127_9014405_1	342949.PNA2_0224	1.626e-42	161.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2437M@183968|Thermococci	183968|Thermococci	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
YHH1_k127_9014405_4	1131814.JAFO01000001_gene4645	6.128e-05	52.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,2UHQ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_9020842_0	479434.Sthe_0851	3.154e-12	79.0	COG5650@1|root,COG5650@2|Bacteria,2GB8F@200795|Chloroflexi,27Y1V@189775|Thermomicrobia	189775|Thermomicrobia	S	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_9040330_0	1112217.PPL19_08326	2.775e-12	76.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1RMDN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	N-acetylmuramoyl-L-alanine amidase	ampDh2	-	3.5.1.28	ko:K01447,ko:K11066	-	-	R04112	RC00064,RC00141	ko00000,ko01000,ko01011	-	-	-	Amidase_2,PG_binding_1,SH3_3
YHH1_k127_9129164_0	1229909.NSED_09885	8.032e-70	244.0	COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
YHH1_k127_9129164_1	456320.Mvol_1181	5.011e-14	82.0	COG1354@1|root,arCOG02610@2157|Archaea,2Y67T@28890|Euryarchaeota,23QS7@183939|Methanococci	183939|Methanococci	L	PFAM chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
YHH1_k127_9129164_2	368408.Tpen_0430	3.641e-05	51.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
YHH1_k127_9145171_1	1188240.MYEA_2390	6.676e-42	167.0	COG0006@1|root,COG0006@2|Bacteria,3WSXU@544448|Tenericutes	544448|Tenericutes	E	XAA-PRO aminopeptidase	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
YHH1_k127_9145171_2	386456.JQKN01000016_gene904	2.505e-17	93.0	COG1468@1|root,arCOG00793@2157|Archaea,2Y05J@28890|Euryarchaeota,23PN6@183925|Methanobacteria	183925|Methanobacteria	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
YHH1_k127_9145171_5	457425.XNR_2599	7.675e-05	52.0	COG1437@1|root,COG1437@2|Bacteria,2GNX6@201174|Actinobacteria	201174|Actinobacteria	F	CYTH domain	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
YHH1_k127_9145171_6	1232410.KI421413_gene654	0.0009212	51.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,43SAE@69541|Desulfuromonadales	28221|Deltaproteobacteria	MU	SMART AAA ATPase	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
YHH1_k127_9145171_4	351160.RCIX690	5.305e-05	49.0	COG1873@1|root,arCOG02155@2157|Archaea,2XYZ2@28890|Euryarchaeota,2NA15@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
YHH1_k127_9145171_3	1458357.BG58_31805	3.481e-13	78.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,2W570@28216|Betaproteobacteria,1K7M5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH1_k127_9145171_0	573064.Mefer_1399	9.411e-112	369.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
YHH1_k127_918432_0	398512.JQKC01000044_gene1271	3.184e-53	197.0	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,3WNBT@541000|Ruminococcaceae	186801|Clostridia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
YHH1_k127_918432_1	391623.TERMP_01727	5.755e-13	71.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
YHH1_k127_9187471_0	979556.MTES_0962	4.066e-06	54.0	COG1716@1|root,COG3266@1|root,COG1716@2|Bacteria,COG3266@2|Bacteria,2GVTI@201174|Actinobacteria,4FQ6S@85023|Microbacteriaceae	201174|Actinobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
YHH1_k127_9259009_1	593750.Metfor_1052	1.014e-50	186.0	arCOG13108@1|root,arCOG13108@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_9259009_0	395493.BegalDRAFT_0901	7.112e-80	269.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,45ZZ4@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
YHH1_k127_929298_1	304371.MCP_2394	7.366e-20	93.0	arCOG03450@1|root,arCOG03450@2157|Archaea,2XV0N@28890|Euryarchaeota,2N9Y1@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_929298_2	718252.FP2_25060	9.981e-05	49.0	COG0484@1|root,COG0484@2|Bacteria,1UWW2@1239|Firmicutes,25CGC@186801|Clostridia,3WJ1B@541000|Ruminococcaceae	186801|Clostridia	O	Psort location Cytoplasmic, score	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
YHH1_k127_929298_0	1122176.KB903538_gene1574	3.252e-99	334.0	COG2723@1|root,COG2723@2|Bacteria,4NEE2@976|Bacteroidetes	2|Bacteria	G	beta-glucosidase	bglB	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
YHH1_k127_930784_0	186497.PF1753	4.657e-107	361.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
YHH1_k127_930784_1	246194.CHY_1865	1.458e-05	51.0	COG1378@1|root,COG1378@2|Bacteria,1UV3K@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
YHH1_k127_9317056_2	272557.APE_2084.1	3.072e-08	64.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
YHH1_k127_9317056_0	263820.PTO0568	8.58e-32	138.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,241PD@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
YHH1_k127_9317056_1	1074488.AGBX01000007_gene2050	6.976e-17	83.0	COG1216@1|root,COG1216@2|Bacteria,2I2J1@201174|Actinobacteria,4FCBA@85020|Dermabacteraceae	201174|Actinobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
YHH1_k127_934608_0	386456.JQKN01000008_gene1391	1.443e-58	225.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
YHH1_k127_9362370_0	679926.Mpet_1520	2.365e-26	110.0	arCOG03403@1|root,arCOG03403@2157|Archaea,2Y5T8@28890|Euryarchaeota	28890|Euryarchaeota	K	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
YHH1_k127_9431649_0	267377.MMP1438	1.401e-47	173.0	COG2340@1|root,arCOG03962@2157|Archaea,2XZ0Y@28890|Euryarchaeota,23RCR@183939|Methanococci	183939|Methanococci	S	PFAM SCP-like extracellular	-	-	-	-	-	-	-	-	-	-	-	-	CAP
YHH1_k127_9431649_4	880072.Desac_0901	2.182e-05	49.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_Mtase
YHH1_k127_9431649_2	868131.MSWAN_0475	9.303e-31	125.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23P4U@183925|Methanobacteria	183925|Methanobacteria	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
YHH1_k127_9431649_1	1047013.AQSP01000126_gene2742	3.521e-37	155.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD,Glutaredoxin,SfLAP
YHH1_k127_9431649_3	565033.GACE_2148	4.885e-27	113.0	COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota,246ZF@183980|Archaeoglobi	183980|Archaeoglobi	P	PFAM zinc iron permease	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
YHH1_k127_9543311_0	246194.CHY_0201	1.158e-26	125.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,42GQY@68295|Thermoanaerobacterales	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
YHH1_k127_9543311_1	197221.22293863	0.0006987	52.0	COG0526@1|root,COG0526@2|Bacteria,1G7MH@1117|Cyanobacteria	1117|Cyanobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_9599695_4	272123.Anacy_2044	6.273e-20	100.0	COG1386@1|root,COG1386@2|Bacteria,1G5XJ@1117|Cyanobacteria,1HIGF@1161|Nostocales	1117|Cyanobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
YHH1_k127_9599695_0	1191523.MROS_1041	5.868e-298	936.0	COG0188@1|root,COG0188@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
YHH1_k127_9599695_5	13333.ERN16916	0.0002844	47.0	KOG1623@1|root,KOG1623@2759|Eukaryota,37KKX@33090|Viridiplantae,3G8PG@35493|Streptophyta	35493|Streptophyta	U	Mediates both low-affinity uptake and efflux of sugar across the membrane	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008515,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015766,GO:0015770,GO:0015772,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K15382	-	-	-	-	ko00000,ko02000	9.A.58.1	-	-	MtN3_slv
YHH1_k127_9599695_3	269797.Mbar_A1039	3.546e-40	157.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
YHH1_k127_9599695_1	580327.Tthe_0062	4.846e-56	203.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,42EZG@68295|Thermoanaerobacterales	186801|Clostridia	M	Transferase hexapeptide repeat	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
YHH1_k127_9599695_2	387631.Asulf_00634	7.915e-55	198.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,245TX@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
YHH1_k127_9649785_0	1209989.TepiRe1_0432	4.616e-49	190.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,42EPW@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
YHH1_k127_9649785_1	908337.HMPREF9257_0510	1.306e-18	92.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,4HBFZ@91061|Bacilli,27DJC@186827|Aerococcaceae	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
YHH1_k127_9705765_1	1321784.HMPREF1987_02038	1.795e-22	102.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,25QPP@186804|Peptostreptococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
YHH1_k127_9705765_0	243232.MJ_0543	1.74e-38	149.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
YHH1_k127_988538_0	243232.MJ_0445	9.151e-32	127.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23QZQ@183939|Methanococci	183939|Methanococci	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
YHH1_k127_9914674_0	386456.JQKN01000002_gene2686	2.248e-19	98.0	arCOG00116@1|root,arCOG00116@2157|Archaea,2XVDZ@28890|Euryarchaeota,23P3A@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
YHH1_k127_9936390_1	1434325.AZQN01000004_gene1617	5.732e-10	72.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,47P47@768503|Cytophagia	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_9936390_0	1254432.SCE1572_07440	3.887e-32	144.0	COG4935@1|root,COG4935@2|Bacteria,1QZT5@1224|Proteobacteria,42YUM@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH1_k127_9936390_2	529818.AMSG_12067T0	0.0006013	53.0	KOG3556@1|root,KOG3556@2759|Eukaryota	2759|Eukaryota	S	protein linear deubiquitination	CYLD	GO:0001775,GO:0001817,GO:0001818,GO:0001959,GO:0002218,GO:0002221,GO:0002253,GO:0002360,GO:0002376,GO:0002520,GO:0002521,GO:0002682,GO:0002683,GO:0002684,GO:0002694,GO:0002695,GO:0002696,GO:0002753,GO:0002757,GO:0002758,GO:0002764,GO:0003674,GO:0003824,GO:0004843,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0006355,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0006979,GO:0007154,GO:0007162,GO:0007165,GO:0007275,GO:0007346,GO:0007568,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008234,GO:0008270,GO:0008340,GO:0009605,GO:0009607,GO:0009617,GO:0009889,GO:0009898,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010259,GO:0010468,GO:0010556,GO:0010646,GO:0010647,GO:0010648,GO:0010803,GO:0010941,GO:0010942,GO:0012501,GO:0015630,GO:0016020,GO:0016043,GO:0016579,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0019783,GO:0019897,GO:0019898,GO:0019899,GO:0019900,GO:0019901,GO:0022407,GO:0022408,GO:0022409,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030097,GO:0030098,GO:0030111,GO:0030154,GO:0030155,GO:0030178,GO:0030217,GO:0030522,GO:0031098,GO:0031234,GO:0031323,GO:0031326,GO:0031344,GO:0031347,GO:0031349,GO:0032088,GO:0032479,GO:0032480,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032886,GO:0033043,GO:0033554,GO:0035556,GO:0035872,GO:0036064,GO:0036211,GO:0036459,GO:0042110,GO:0042592,GO:0042742,GO:0042981,GO:0042995,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043368,GO:0043369,GO:0043393,GO:0043412,GO:0043433,GO:0043933,GO:0044085,GO:0044087,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045058,GO:0045087,GO:0045088,GO:0045089,GO:0045165,GO:0045321,GO:0045577,GO:0045580,GO:0045581,GO:0045582,GO:0045595,GO:0045596,GO:0045597,GO:0045619,GO:0045620,GO:0045621,GO:0045785,GO:0046649,GO:0046872,GO:0046914,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048583,GO:0048584,GO:0048585,GO:0048731,GO:0048856,GO:0048869,GO:0048872,GO:0048878,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050854,GO:0050856,GO:0050857,GO:0050862,GO:0050863,GO:0050864,GO:0050865,GO:0050866,GO:0050867,GO:0050868,GO:0050870,GO:0050896,GO:0051090,GO:0051093,GO:0051094,GO:0051098,GO:0051128,GO:0051171,GO:0051239,GO:0051240,GO:0051241,GO:0051249,GO:0051250,GO:0051251,GO:0051252,GO:0051493,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0055088,GO:0055090,GO:0060255,GO:0060341,GO:0060491,GO:0060759,GO:0060828,GO:0061578,GO:0061815,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070011,GO:0070064,GO:0070265,GO:0070266,GO:0070423,GO:0070507,GO:0070536,GO:0070646,GO:0070647,GO:0071108,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0090090,GO:0097300,GO:0097343,GO:0097542,GO:0098542,GO:0098552,GO:0098562,GO:0101005,GO:0120025,GO:0120032,GO:0120035,GO:0120038,GO:0140096,GO:1901026,GO:1901222,GO:1901223,GO:1901564,GO:1902017,GO:1902105,GO:1902106,GO:1902107,GO:1902115,GO:1902531,GO:1902532,GO:1903037,GO:1903038,GO:1903039,GO:1903506,GO:1903706,GO:1903707,GO:1903708,GO:1903827,GO:1903829,GO:1990108,GO:1990380,GO:2000026,GO:2000112,GO:2001141,GO:2001233,GO:2001235,GO:2001236,GO:2001238,GO:2001242	3.4.19.12	ko:K08601	ko04013,ko04217,ko04380,ko04622,map04013,map04217,map04380,map04622	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04121	-	-	-	CAP_GLY,CYLD_phos_site,UCH
YHH1_k127_9962140_0	186497.PF1392	6.118e-51	190.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
YHH1_k127_9962140_1	647113.Metok_0033	1.437e-24	105.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,23QFN@183939|Methanococci	183939|Methanococci	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:2000112,GO:2000765	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
YHH1_k127_9973298_2	1123508.JH636439_gene853	1.681e-32	131.0	COG2606@1|root,COG2606@2|Bacteria,2J1EW@203682|Planctomycetes	203682|Planctomycetes	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
YHH1_k127_9973298_0	273068.TTE1231	1.037e-152	497.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,42EM9@68295|Thermoanaerobacterales	186801|Clostridia	J	L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
YHH1_k127_9973298_1	795359.TOPB45_0317	2.806e-62	221.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
YHH1_k127_9983899_0	351160.RCIX2217	4.36e-65	235.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
YHH1_k127_9983899_1	386456.JQKN01000007_gene3244	2.894e-15	85.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y780@28890|Euryarchaeota,23P2D@183925|Methanobacteria	183925|Methanobacteria	N	type II secretion	gspF1	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
YHH1_k127_9983899_2	1122614.JHZF01000013_gene3984	1.063e-08	66.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,2PCAH@252301|Oceanicola	28211|Alphaproteobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
YHH1_k127_9987611_0	1347392.CCEZ01000018_gene1122	7.992e-29	119.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,36ETN@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
YHH1_k127_9987611_2	349161.Dred_1304	0.000393	48.0	COG4766@1|root,COG4766@2|Bacteria,1V4U8@1239|Firmicutes,24807@186801|Clostridia,26243@186807|Peptococcaceae	186801|Clostridia	E	Ethanolamine utilisation	-	-	-	ko:K04030	-	-	-	-	ko00000	-	-	-	EutQ
YHH1_k127_9987611_1	1380393.JHVP01000002_gene1722	6.057e-07	59.0	COG3428@1|root,COG3428@2|Bacteria,2GK6Y@201174|Actinobacteria,4EVYI@85013|Frankiales	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
YHH1_k127_9999404_0	868595.Desca_0169	1.82e-168	542.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,260CD@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
## 667 queries scanned
## Total time (seconds): 20.920073747634888
## Rate: 31.88 q/s