## Wed Dec 17 13:12:33 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/YHH3_bin.80.fa -m mmseqs --itype genome -o YHH3_bin.80 --output_dir /data/result/bins/wyx/egg/YHH3_bin.80 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
YHH3_k127_10019205_2	1232410.KI421415_gene2936	3.305e-11	73.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH3_k127_10019205_0	349161.Dred_1493	3.591e-79	277.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,2648P@186807|Peptococcaceae	186801|Clostridia	C	PFAM 3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
YHH3_k127_10019205_1	401526.TcarDRAFT_1841	2.161e-25	111.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4H217@909932|Negativicutes	909932|Negativicutes	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
YHH3_k127_10021395_0	391623.TERMP_00151	3.401e-46	178.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,242X8@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
YHH3_k127_10021395_2	1033806.HTIA_1900	1.506e-10	73.0	COG0642@1|root,arCOG02376@1|root,arCOG02376@2157|Archaea,arCOG06408@2157|Archaea,2Y821@28890|Euryarchaeota	28890|Euryarchaeota	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
YHH3_k127_10049942_0	1343739.PAP_03020	1.367e-41	164.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTKZ@28890|Euryarchaeota,243BY@183968|Thermococci	183968|Thermococci	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
YHH3_k127_10049942_1	926692.AZYG01000019_gene197	0.0004705	50.0	COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,3WAJ1@53433|Halanaerobiales	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
YHH3_k127_10050674_3	1123054.KB907711_gene361	3.823e-27	119.0	COG1404@1|root,COG3266@1|root,COG1404@2|Bacteria,COG3266@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,1WXY7@135613|Chromatiales	135613|Chromatiales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_10050674_1	521011.Mpal_2716	8.178e-85	290.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2NA8Q@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM thiamine pyrophosphate enzyme	porB-2	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
YHH3_k127_10050674_0	1343739.PAP_04310	4.811e-107	359.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,242N1@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorA	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
YHH3_k127_10050674_4	694440.JOMF01000004_gene1246	1.103e-26	112.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota	28890|Euryarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	porD	-	1.2.7.1,1.2.7.7	ko:K00171,ko:K00188	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_6
YHH3_k127_10050674_2	717606.PaecuDRAFT_3213	3.521e-50	188.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,4HC44@91061|Bacilli,26QCB@186822|Paenibacillaceae	91061|Bacilli	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	mtnU	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
YHH3_k127_10050674_5	420247.Msm_1265	0.0005437	49.0	COG5440@1|root,arCOG01713@2157|Archaea,2XYFI@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized conserved protein (DUF2299)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2299
YHH3_k127_10090229_0	1260356.D920_02103	7.211e-09	60.0	COG2197@1|root,COG2197@2|Bacteria,1TW4Y@1239|Firmicutes,4HEJE@91061|Bacilli,4B2TY@81852|Enterococcaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	yfiK	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
YHH3_k127_10099869_0	1232437.KL661965_gene3264	4.223e-119	398.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria,42WP6@68525|delta/epsilon subdivisions,2WSCA@28221|Deltaproteobacteria,2MNZT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Ethanolamine utilisation protein EutA	-	-	-	-	-	-	-	-	-	-	-	-	EutA
YHH3_k127_10099869_3	868131.MSWAN_2238	1.651e-32	132.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
YHH3_k127_10099869_4	113395.AXAI01000016_gene5063	1.617e-31	127.0	COG3602@1|root,COG3602@2|Bacteria,1MZKQ@1224|Proteobacteria,2U85U@28211|Alphaproteobacteria,3JZ4P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ACT domain	-	-	-	ko:K09964	-	-	-	-	ko00000	-	-	-	ACT_3,ACT_7
YHH3_k127_10099869_5	796940.HMPREF9628_00616	1.316e-16	87.0	COG3467@1|root,COG3467@2|Bacteria,1V2WR@1239|Firmicutes,25KC7@186801|Clostridia,25TXN@186804|Peptostreptococcaceae	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
YHH3_k127_10099869_1	1408473.JHXO01000010_gene3609	3.006e-108	359.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FX64@200643|Bacteroidia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
YHH3_k127_10099869_2	679926.Mpet_1138	2.888e-41	175.0	COG0642@1|root,COG2202@1|root,arCOG06712@1|root,arCOG06940@1|root,arCOG06193@2157|Archaea,arCOG06712@2157|Archaea,arCOG06918@2157|Archaea,arCOG06940@2157|Archaea,2XWN9@28890|Euryarchaeota,2NANJ@224756|Methanomicrobia	2157|Archaea	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,PocR,Response_reg
YHH3_k127_10110529_5	1229831.M832_08500	8.212e-11	74.0	COG0457@1|root,COG0457@2|Bacteria	1229831.M832_08500|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_10110529_3	382464.ABSI01000011_gene2329	3.501e-27	121.0	COG4076@1|root,COG4076@2|Bacteria,46W2E@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.319	ko:K11434	ko04068,ko04922,map04068,map04922	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko00001,ko01000,ko03036	-	-	-	PrmA
YHH3_k127_10110529_2	1042877.GQS_02055	2.645e-58	211.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,24312@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
YHH3_k127_10110529_0	643648.Slip_0897	2.624e-80	276.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42JJA@68298|Syntrophomonadaceae	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
YHH3_k127_10110529_1	604354.TSIB_1816	2.451e-62	223.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,245B1@183968|Thermococci	183968|Thermococci	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
YHH3_k127_10110529_4	1120999.JONM01000002_gene597	7.884e-23	102.0	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,2KRZZ@206351|Neisseriales	206351|Neisseriales	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
YHH3_k127_10110529_6	323259.Mhun_1509	7.813e-06	55.0	COG0457@1|root,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_19,TPR_2,TPR_8
YHH3_k127_10121581_1	572546.Arcpr_1284	0.0001065	48.0	COG0526@1|root,arCOG02713@2157|Archaea	2157|Archaea	C	Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0055114	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
YHH3_k127_10121581_0	572546.Arcpr_0010	1.083e-169	557.0	COG1328@1|root,COG2074@1|root,arCOG01967@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,NRDD
YHH3_k127_1015055_2	1167006.UWK_00583	9.404e-67	243.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
YHH3_k127_1015055_0	1343740.M271_44650	3.999e-153	500.0	COG1027@1|root,COG1027@2|Bacteria,2I2HG@201174|Actinobacteria	201174|Actinobacteria	E	Aspartate ammonia-lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
YHH3_k127_1015055_1	266117.Rxyl_0295	3.601e-126	420.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4CR8G@84995|Rubrobacteria	84995|Rubrobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
YHH3_k127_10155474_0	5888.CAK73159	1.276e-22	100.0	COG1100@1|root,KOG0097@2759|Eukaryota	2759|Eukaryota	J	Golgi to endosome transport	RAB14	GO:0000166,GO:0000323,GO:0000331,GO:0001775,GO:0001845,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005773,GO:0005774,GO:0005783,GO:0005791,GO:0005794,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006661,GO:0006793,GO:0006796,GO:0006810,GO:0006873,GO:0006885,GO:0006887,GO:0006892,GO:0006895,GO:0006897,GO:0006909,GO:0006950,GO:0006952,GO:0006955,GO:0006970,GO:0006996,GO:0007033,GO:0007040,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007264,GO:0007265,GO:0007589,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008543,GO:0008610,GO:0008654,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009719,GO:0009987,GO:0010008,GO:0010033,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016324,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019637,GO:0019725,GO:0022607,GO:0023052,GO:0030003,GO:0030004,GO:0030100,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030140,GO:0030141,GO:0030641,GO:0030659,GO:0030667,GO:0031090,GO:0031164,GO:0031338,GO:0031410,GO:0031489,GO:0031901,GO:0031982,GO:0031984,GO:0032456,GO:0032482,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0033043,GO:0033298,GO:0035556,GO:0035639,GO:0036094,GO:0036230,GO:0036477,GO:0042119,GO:0042175,GO:0042221,GO:0042592,GO:0042599,GO:0042742,GO:0043025,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043277,GO:0043299,GO:0043312,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044297,GO:0044344,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045017,GO:0045055,GO:0045176,GO:0045177,GO:0045202,GO:0045321,GO:0045335,GO:0045851,GO:0045995,GO:0046474,GO:0046486,GO:0046488,GO:0046903,GO:0046907,GO:0048193,GO:0048471,GO:0048548,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050878,GO:0050896,GO:0051049,GO:0051128,GO:0051179,GO:0051234,GO:0051239,GO:0051452,GO:0051453,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0055037,GO:0055038,GO:0055067,GO:0055080,GO:0055082,GO:0060627,GO:0065007,GO:0065008,GO:0070820,GO:0070821,GO:0070848,GO:0070887,GO:0070925,GO:0071310,GO:0071363,GO:0071495,GO:0071704,GO:0071774,GO:0071840,GO:0071944,GO:0080171,GO:0090382,GO:0090383,GO:0090386,GO:0090387,GO:0090390,GO:0090407,GO:0097159,GO:0097208,GO:0097367,GO:0097458,GO:0097708,GO:0098542,GO:0098588,GO:0098590,GO:0098657,GO:0098771,GO:0098791,GO:0098805,GO:0098852,GO:0099503,GO:1901265,GO:1901363,GO:1901576,GO:1905364,GO:2000026	-	ko:K07877,ko:K07881	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_10155474_1	706587.Desti_2578	2.014e-10	71.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
YHH3_k127_10161859_0	926692.AZYG01000019_gene249	4.484e-33	129.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3WACS@53433|Halanaerobiales	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
YHH3_k127_10161859_1	59374.Fisuc_1497	5.642e-08	63.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.73	ko:K02226,ko:K07814	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	His_Phos_1
YHH3_k127_10162208_0	935845.JADQ01000007_gene1618	2.807e-06	51.0	2DNMR@1|root,32Y5G@2|Bacteria,1VHJG@1239|Firmicutes,4HNHI@91061|Bacilli,270KN@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_10162366_0	258052.JNYV01000008_gene3518	1.596e-15	85.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,2M1QC@2063|Kitasatospora	201174|Actinobacteria	E	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
YHH3_k127_10175187_3	426368.MmarC7_0574	7.574e-05	48.0	COG1146@1|root,arCOG00959@2157|Archaea,2Y10S@28890|Euryarchaeota,23R86@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
YHH3_k127_10175187_1	1121468.AUBR01000028_gene1506	4.725e-42	166.0	COG1149@1|root,COG1149@2|Bacteria,1VDSQ@1239|Firmicutes,24NTS@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_10175187_0	765177.Desmu_0309	1.635e-107	358.0	COG0448@1|root,arCOG00912@2157|Archaea,2XPXX@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
YHH3_k127_10175187_2	56107.Cylst_0879	7.252e-09	65.0	COG0457@1|root,COG1193@1|root,COG5022@1|root,COG0457@2|Bacteria,COG1193@2|Bacteria,COG5022@2|Bacteria,1G1U5@1117|Cyanobacteria,1HJ1H@1161|Nostocales	1117|Cyanobacteria	M	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
YHH3_k127_10187680_0	224325.AF_1153	8.504e-60	221.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,246RQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
YHH3_k127_10187680_1	1207063.P24_03875	1.079e-14	78.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JQBC@204441|Rhodospirillales	204441|Rhodospirillales	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
YHH3_k127_10214936_1	926561.KB900617_gene1868	2.586e-39	155.0	COG0491@1|root,COG0491@2|Bacteria,1VHN6@1239|Firmicutes,24AT7@186801|Clostridia	186801|Clostridia	S	Zn-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_10214936_0	373903.Hore_08800	8.352e-77	269.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,3WA6M@53433|Halanaerobiales	186801|Clostridia	S	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
YHH3_k127_10245360_1	1168034.FH5T_20550	8.344e-66	237.0	COG2223@1|root,COG2223@2|Bacteria,4NHX9@976|Bacteroidetes,2FZ04@200643|Bacteroidia	976|Bacteroidetes	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
YHH3_k127_10245360_0	1125863.JAFN01000001_gene2044	4.434e-193	621.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
YHH3_k127_10245360_2	1265505.ATUG01000001_gene4538	4.228e-59	216.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2MI42@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
YHH3_k127_10270726_0	2423.NA23_0203550	1.547e-59	213.0	COG1136@1|root,COG1136@2|Bacteria,2GCNW@200918|Thermotogae	200918|Thermotogae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_10270726_1	1169152.AXVD01000030_gene4497	9.31e-15	89.0	COG0577@1|root,COG0577@2|Bacteria,2HHSC@201174|Actinobacteria,4FZWK@85025|Nocardiaceae	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_10270726_2	1416760.AYMS01000012_gene913	4.938e-08	64.0	COG1695@1|root,COG1695@2|Bacteria,4NSI4@976|Bacteroidetes,1I2SA@117743|Flavobacteriia,47IBY@76831|Myroides	976|Bacteroidetes	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
YHH3_k127_1027906_4	711393.AYRX01000034_gene182	6.695e-10	65.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria	201174|Actinobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_1027906_1	632518.Calow_0431	9.373e-77	275.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,42EP0@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM carbohydrate kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
YHH3_k127_1027906_0	1232453.BAIF02000075_gene4856	4.096e-98	341.0	COG0578@1|root,COG0578@2|Bacteria,1UJ0S@1239|Firmicutes,25ETI@186801|Clostridia	186801|Clostridia	C	TIGRFAM Glycerol-3-phosphate dehydrogenase, anaerobic A subunit	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
YHH3_k127_1027906_2	335543.Sfum_3498	1.178e-46	185.0	COG3075@1|root,COG3075@2|Bacteria,1MU3K@1224|Proteobacteria,42Q09@68525|delta/epsilon subdivisions,2WKE0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
YHH3_k127_1027906_3	444158.MmarC6_1592	1.223e-11	74.0	COG0247@1|root,COG0479@1|root,arCOG00333@2157|Archaea,arCOG00963@2157|Archaea,2Y85M@28890|Euryarchaeota,23QEF@183939|Methanococci	183939|Methanococci	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0022900,GO:0022904,GO:0044237,GO:0045333,GO:0055114	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
YHH3_k127_10302991_0	342949.PNA2_1365	2.069e-75	259.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
YHH3_k127_10302991_2	639282.DEFDS_0486	3.617e-60	212.0	COG2131@1|root,COG2131@2|Bacteria,2GFK7@200930|Deferribacteres	200930|Deferribacteres	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
YHH3_k127_10302991_9	192952.MM_1557	1.463e-12	72.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68X@28890|Euryarchaeota,2NA5V@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
YHH3_k127_10302991_8	186497.PF1791	9.713e-15	76.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,244GS@183968|Thermococci	183968|Thermococci	J	H ACA RNA-protein complex	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
YHH3_k127_10302991_11	1163730.FFONT_1223	1.566e-05	52.0	COG1522@1|root,arCOG04153@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	rpc34	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC,HTH_24,MarR
YHH3_k127_10302991_6	224325.AF_2051	5.357e-41	158.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,245SF@183980|Archaeoglobi	183980|Archaeoglobi	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
YHH3_k127_10302991_1	339860.Msp_0291	1.193e-64	237.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
YHH3_k127_10302991_3	1185876.BN8_04452	3.901e-56	200.0	COG0652@1|root,COG0652@2|Bacteria,4NKQ7@976|Bacteroidetes,47P72@768503|Cytophagia	976|Bacteroidetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
YHH3_k127_10302991_7	387631.Asulf_01203	8.074e-37	147.0	COG2220@1|root,arCOG00497@2157|Archaea,2XUPM@28890|Euryarchaeota	28890|Euryarchaeota	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
YHH3_k127_10302991_5	1128421.JAGA01000003_gene2815	1.6e-43	170.0	COG1082@1|root,COG1082@2|Bacteria,2NRRT@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
YHH3_k127_10302991_4	1541960.KQ78_01428	9.494e-44	166.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
YHH3_k127_10302991_10	1050201.KB913034_gene114	7.184e-06	57.0	COG0693@1|root,COG0693@2|Bacteria,1V3WB@1239|Firmicutes,3VQHE@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
YHH3_k127_10318919_0	1173020.Cha6605_0959	2.39e-42	162.0	COG0508@1|root,COG0508@2|Bacteria,1G4MH@1117|Cyanobacteria	1117|Cyanobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
YHH3_k127_10319553_0	1121434.AULY01000009_gene2031	7.604e-164	534.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2M9FS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
YHH3_k127_10319553_1	1123508.JH636440_gene1975	4.879e-93	316.0	COG0524@1|root,COG0524@2|Bacteria,2IWUH@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
YHH3_k127_10319553_2	234267.Acid_5289	1.163e-57	207.0	COG0800@1|root,COG0800@2|Bacteria,3Y4HZ@57723|Acidobacteria	57723|Acidobacteria	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
YHH3_k127_10319553_4	211165.AJLN01000066_gene4498	0.0009015	46.0	COG1600@1|root,COG3255@1|root,COG1600@2|Bacteria,COG3255@2|Bacteria,1G07Y@1117|Cyanobacteria	1117|Cyanobacteria	CI	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4,Fer4_7,SCP2
YHH3_k127_10319553_3	293826.Amet_0445	4.734e-38	160.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36GQP@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_10350082_0	453591.Igni_1383	4.681e-37	151.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
YHH3_k127_1036064_0	521011.Mpal_2732	9.218e-12	78.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7N5@28890|Euryarchaeota	28890|Euryarchaeota	T	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS,NACHT
YHH3_k127_1041623_3	399550.Smar_1029	3.237e-34	134.0	COG0093@1|root,arCOG04095@2157|Archaea,2XQPU@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
YHH3_k127_1041623_4	439481.Aboo_1512	3.239e-34	134.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,3F2Q9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
YHH3_k127_1041623_6	868131.MSWAN_1462	1.497e-17	85.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
YHH3_k127_1041623_9	453591.Igni_0591	4.89e-08	56.0	COG0255@1|root,arCOG00785@2157|Archaea,2XRDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uL29 family	rpl29	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
YHH3_k127_1041623_1	523850.TON_0072	1.597e-55	205.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
YHH3_k127_1041623_2	593117.TGAM_1998	4.037e-42	159.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,243D0@183968|Thermococci	183968|Thermococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
YHH3_k127_1041623_7	604354.TSIB_1472	2.151e-16	82.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZY3@28890|Euryarchaeota,244JJ@183968|Thermococci	183968|Thermococci	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	korD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
YHH3_k127_1041623_8	985053.VMUT_0097	2.217e-15	83.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1041623_5	243232.MJ_0319	3.9e-27	113.0	COG1888@1|root,arCOG04140@2157|Archaea,2Y02A@28890|Euryarchaeota,23R3F@183939|Methanococci	183939|Methanococci	S	Uncharacterized ArCR, COG1888	-	-	-	ko:K09732	-	-	-	-	ko00000	-	-	-	DUF211
YHH3_k127_1041623_0	643648.Slip_0391	5.538e-106	355.0	COG0409@1|root,COG0409@2|Bacteria,1TPM7@1239|Firmicutes,248EX@186801|Clostridia,42KHA@68298|Syntrophomonadaceae	186801|Clostridia	O	PFAM hydrogenase formation HypD protein	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
YHH3_k127_10436352_1	573064.Mefer_0243	2.759e-27	112.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,23Q0U@183939|Methanococci	183939|Methanococci	C	TIGRFAM formylmethanofuran dehydrogenase subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
YHH3_k127_10436352_0	573064.Mefer_0155	4.882e-159	520.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,23QNZ@183939|Methanococci	183939|Methanococci	C	PFAM Amidohydrolase 3	fwdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
YHH3_k127_10436352_2	744980.TRICHSKD4_1950	6.91e-05	53.0	COG1268@1|root,COG1268@2|Bacteria,1RD2B@1224|Proteobacteria,2U6U5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	BioY protein	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
YHH3_k127_1047980_1	314275.MADE_1012625	3.849e-05	57.0	COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
YHH3_k127_1047980_0	700598.Niako_5872	7.957e-07	62.0	COG3533@1|root,COG4733@1|root,COG3533@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.14,3.2.1.99	ko:K01183,ko:K06113	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18,GH43	-	Big_2,Cadherin-like,Glyco_hydro_127,Laminin_G_3,SLH,fn3
YHH3_k127_10526689_0	68170.KL590490_gene1267	1.236e-21	113.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
YHH3_k127_10554522_0	397948.Cmaq_0710	2.627e-77	271.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_10554522_1	224719.Abm4_0734	2.005e-20	96.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,23PNF@183925|Methanobacteria	183925|Methanobacteria	L	excinuclease ABC, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
YHH3_k127_10599502_1	1281779.H009_20336	5.706e-05	49.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,4B7JE@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_10599502_0	1453500.AT05_08730	1.707e-41	166.0	COG2222@1|root,COG2222@2|Bacteria,4NIX0@976|Bacteroidetes	976|Bacteroidetes	M	Bifunctional phosphoglucose phosphomannose isomerase	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
YHH3_k127_10626717_2	215358.XP_010729904.1	5.98e-05	46.0	COG1100@1|root,KOG0091@2759|Eukaryota,38CIZ@33154|Opisthokonta,3BH8W@33208|Metazoa,3CSAN@33213|Bilateria,48A3Y@7711|Chordata,48XHH@7742|Vertebrata,49RSQ@7898|Actinopterygii	33208|Metazoa	U	RAB42, member RAS oncogene family	rab42	-	-	ko:K07925	-	-	-	-	ko00000,ko04031	-	-	-	Ras
YHH3_k127_10626717_0	269797.Mbar_A1315	5.596e-48	189.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
YHH3_k127_10626717_1	742767.HMPREF9456_01431	1.501e-17	87.0	COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,2FM38@200643|Bacteroidia,22WX0@171551|Porphyromonadaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
YHH3_k127_10701455_1	426117.M446_0671	1.029e-09	71.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,1JUDI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	MA20_19540	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_10701455_2	1243664.CAVL020000043_gene2658	8.431e-06	59.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,1ZF2K@1386|Bacillus	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_10701455_0	65497.JODV01000021_gene2130	6.772e-13	82.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4E0AJ@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_10705919_1	2325.TKV_c01280	2.77e-12	72.0	2DDNA@1|root,2ZIND@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_10705919_0	1343739.PAP_03225	5.929e-33	133.0	COG0437@1|root,arCOG01500@2157|Archaea,2XU83@28890|Euryarchaeota,24376@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4
YHH3_k127_10705919_3	2325.TKV_c19680	4.9e-08	59.0	COG1143@1|root,COG1143@2|Bacteria,1UD4T@1239|Firmicutes,25AJ1@186801|Clostridia,42IJC@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	ko:K12143	-	-	-	-	ko00000	-	-	-	Fer4
YHH3_k127_10753560_0	342949.PNA2_1872	1.733e-117	394.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_10753560_1	1184251.TCELL_0575	3.012e-21	106.0	COG0312@1|root,arCOG00322@2157|Archaea,2XPJX@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_10755586_4	1184251.TCELL_0850	4.065e-37	143.0	COG0409@1|root,arCOG04428@2157|Archaea,2XPKY@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM hydrogenase formation HypD protein	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
YHH3_k127_10755586_5	374847.Kcr_0553	3.056e-27	119.0	COG0746@1|root,arCOG01872@2157|Archaea	2157|Archaea	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
YHH3_k127_10755586_0	868131.MSWAN_2320	1.44e-231	734.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23NUK@183925|Methanobacteria	183925|Methanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
YHH3_k127_10755586_2	523850.TON_1065	6.226e-69	242.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
YHH3_k127_10755586_6	365044.Pnap_2813	2.878e-16	83.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
YHH3_k127_10755586_3	523850.TON_0362	6.553e-62	224.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
YHH3_k127_10755586_1	224325.AF_1299	7.571e-107	355.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
YHH3_k127_10757244_0	224719.Abm4_0702	2.488e-08	68.0	COG1305@1|root,arCOG03946@1|root,arCOG02165@2157|Archaea,arCOG02486@2157|Archaea,arCOG03946@2157|Archaea,2XXMP@28890|Euryarchaeota,23PG0@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015,PMBR,Transglut_core
YHH3_k127_10780528_0	1347086.CCBA010000026_gene3180	2.396e-53	211.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,4HF5S@91061|Bacilli,1ZEHD@1386|Bacillus	91061|Bacilli	O	COG1138 Cytochrome c biogenesis factor	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
YHH3_k127_10780528_1	1536773.R70331_08915	0.000232	54.0	COG2942@1|root,COG2942@2|Bacteria,1TQMG@1239|Firmicutes,4HE7U@91061|Bacilli,26T2B@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)	rnbP	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
YHH3_k127_10806251_0	933262.AXAM01000005_gene2471	2.283e-21	98.0	COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria,2MM8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
YHH3_k127_10812688_0	1408254.T458_00580	2.098e-57	209.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,4HBV3@91061|Bacilli	91061|Bacilli	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
YHH3_k127_10812688_1	177437.HRM2_40030	0.0003096	53.0	COG0477@1|root,COG0477@2|Bacteria,1QWNY@1224|Proteobacteria,43BTW@68525|delta/epsilon subdivisions,2X74T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_10821818_1	984262.SGRA_3406	0.0001317	49.0	2EIVC@1|root,33CKQ@2|Bacteria,4NY8R@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_10821818_0	269797.Mbar_A2330	1.964e-29	122.0	COG0500@1|root,arCOG01773@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH3_k127_10825913_1	1343739.PAP_08000	4.3e-58	206.0	COG4799@1|root,arCOG02705@2157|Archaea,2XSVM@28890|Euryarchaeota,2430E@183968|Thermococci	183968|Thermococci	I	Carboxyl transferase domain	mmdA	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
YHH3_k127_10825913_0	1278073.MYSTI_01161	1.111e-70	241.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
YHH3_k127_10840255_1	391623.TERMP_00518	1.023e-35	144.0	COG0624@1|root,arCOG01107@2157|Archaea,2Y315@28890|Euryarchaeota,242ZX@183968|Thermococci	183968|Thermococci	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
YHH3_k127_10840255_0	1094980.Mpsy_0259	8.616e-93	322.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
YHH3_k127_10882597_0	1443665.JACA01000049_gene5417	2.243e-61	229.0	COG4219@1|root,COG4219@2|Bacteria,4NDWS@976|Bacteroidetes,1I3KX@117743|Flavobacteriia,2YJ63@290174|Aquimarina	976|Bacteroidetes	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
YHH3_k127_1090794_0	368408.Tpen_0613	4.443e-83	287.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
YHH3_k127_1091832_0	635013.TherJR_1489	3.191e-66	234.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,260PA@186807|Peptococcaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
YHH3_k127_1091832_1	267377.MMP0911	1.015e-09	62.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVMU@28890|Euryarchaeota,23QEP@183939|Methanococci	183939|Methanococci	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_10953701_0	608506.COB47_1747	1.521e-20	96.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
YHH3_k127_11011898_2	572546.Arcpr_1414	2.381e-36	145.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2465V@183980|Archaeoglobi	183980|Archaeoglobi	S	Zinc finger domain	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
YHH3_k127_11011898_0	693661.Arcve_1981	2.555e-69	258.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,246Q1@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_11011898_1	926569.ANT_18640	1.27e-49	184.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
YHH3_k127_1101543_0	102129.Lepto7375DRAFT_0197	5.419e-143	464.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
YHH3_k127_1101543_1	251229.Chro_3389	1.501e-45	171.0	2CYFR@1|root,32T44@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
YHH3_k127_1101543_2	1235793.C809_03930	4.194e-05	54.0	28Q1F@1|root,2ZCJT@2|Bacteria,1VI7R@1239|Firmicutes,24D4W@186801|Clostridia,27M4D@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11034647_1	13690.CP98_04433	1.973e-08	62.0	COG1309@1|root,COG1309@2|Bacteria,1N28W@1224|Proteobacteria,2VEWR@28211|Alphaproteobacteria,2KAFP@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
YHH3_k127_11034647_0	368407.Memar_2430	1.179e-224	713.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	2157|Archaea	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11055715_2	693661.Arcve_0239	2.881e-91	304.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,246SZ@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
YHH3_k127_11055715_1	1123288.SOV_1c07320	1.697e-106	359.0	COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,4H2PA@909932|Negativicutes	909932|Negativicutes	O	FeS assembly protein SUFB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
YHH3_k127_11055715_3	1410622.JNKY01000010_gene1173	1.248e-55	203.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,2489I@186801|Clostridia,27J4C@186928|unclassified Lachnospiraceae	186801|Clostridia	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
YHH3_k127_11055715_7	439235.Dalk_4975	1.591e-11	71.0	COG1433@1|root,COG1433@2|Bacteria,1N8RP@1224|Proteobacteria,42W3C@68525|delta/epsilon subdivisions,2WRJB@28221|Deltaproteobacteria,2MKUU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
YHH3_k127_11055715_6	237368.SCABRO_03297	3.854e-16	85.0	COG1633@1|root,COG1633@2|Bacteria,2J3U9@203682|Planctomycetes	203682|Planctomycetes	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
YHH3_k127_11055715_0	1499967.BAYZ01000180_gene4413	1.096e-168	540.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11055715_5	1343739.PAP_04395	4.079e-29	124.0	COG4720@1|root,arCOG05752@2157|Archaea,2XYJ2@28890|Euryarchaeota,243PD@183968|Thermococci	183968|Thermococci	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
YHH3_k127_11055715_4	387631.Asulf_01218	1.663e-46	170.0	COG2033@1|root,arCOG02146@2157|Archaea,2Y3EA@28890|Euryarchaeota	28890|Euryarchaeota	C	Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide	sorA	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
YHH3_k127_11055715_8	105420.BBPO01000005_gene2853	1.175e-06	55.0	COG0346@1|root,COG0346@2|Bacteria,2IHX4@201174|Actinobacteria,2NIWB@228398|Streptacidiphilus	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
YHH3_k127_11065909_0	589924.Ferp_1018	1.329e-47	175.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
YHH3_k127_11065909_1	362242.MUL_3321	4.96e-16	83.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,236EE@1762|Mycobacteriaceae	201174|Actinobacteria	P	transport of arsenical compounds across the membrane (export) arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane	arsA	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
YHH3_k127_11096756_0	273068.TTE0811	1.75e-112	383.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,42F8R@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
YHH3_k127_11096756_2	323259.Mhun_2474	1.992e-39	164.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
YHH3_k127_11096756_1	1131266.ARWQ01000006_gene219	1.325e-81	289.0	COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
YHH3_k127_11096756_3	673860.AciM339_1413	3.554e-11	65.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,3F2H0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
YHH3_k127_11136492_5	5478.XP_445802.1	3.367e-31	129.0	KOG0394@1|root,KOG0394@2759|Eukaryota,38C61@33154|Opisthokonta,3NWMV@4751|Fungi,3QKEZ@4890|Ascomycota,3RSFU@4891|Saccharomycetes,3RYBT@4893|Saccharomycetaceae	4751|Fungi	U	to Saccharomyces cerevisiae YPT7 (YML001W)	-	GO:0000011,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005773,GO:0005774,GO:0006810,GO:0006873,GO:0006885,GO:0006886,GO:0006892,GO:0006896,GO:0006897,GO:0006914,GO:0006996,GO:0007033,GO:0007034,GO:0007035,GO:0007154,GO:0007165,GO:0007264,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010638,GO:0010639,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016236,GO:0016237,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019725,GO:0019867,GO:0023052,GO:0030003,GO:0030004,GO:0030641,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032258,GO:0032889,GO:0033036,GO:0033043,GO:0033365,GO:0034613,GO:0034727,GO:0035556,GO:0042144,GO:0042147,GO:0042592,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044088,GO:0044090,GO:0044232,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044429,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044804,GO:0045184,GO:0045851,GO:0046907,GO:0048193,GO:0048284,GO:0048308,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0051641,GO:0051649,GO:0051716,GO:0055067,GO:0055080,GO:0055082,GO:0061024,GO:0061025,GO:0061191,GO:0061192,GO:0061919,GO:0065007,GO:0065008,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0072665,GO:0097576,GO:0098588,GO:0098657,GO:0098771,GO:0098805,GO:0098852,GO:1990816	-	ko:K07897	ko04137,ko04138,ko04140,ko04144,ko04145,ko05132,ko05146,ko05152,map04137,map04138,map04140,map04144,map04145,map05132,map05146,map05152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_11136492_4	309799.DICTH_1024	4.816e-50	193.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
YHH3_k127_11136492_7	797302.Halru_0692	1.25e-08	61.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XZDR@28890|Euryarchaeota,23XD6@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11136492_1	1459636.NTE_00007	1.59e-100	355.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
YHH3_k127_11136492_3	419665.Maeo_0157	1.061e-59	225.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23QR0@183939|Methanococci	183939|Methanococci	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
YHH3_k127_11136492_2	1094980.Mpsy_1814	6.717e-63	225.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
YHH3_k127_11136492_0	192952.MM_1224	1.001e-131	435.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
YHH3_k127_11136492_6	224719.Abm4_1518	6.404e-27	112.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
YHH3_k127_11164526_1	552811.Dehly_1212	1.244e-12	77.0	COG1238@1|root,COG1238@2|Bacteria,2GARJ@200795|Chloroflexi,34D6F@301297|Dehalococcoidia	301297|Dehalococcoidia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
YHH3_k127_11164526_2	552811.Dehly_1212	2.188e-11	73.0	COG1238@1|root,COG1238@2|Bacteria,2GARJ@200795|Chloroflexi,34D6F@301297|Dehalococcoidia	301297|Dehalococcoidia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
YHH3_k127_11164526_0	926561.KB900618_gene118	1.675e-39	162.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,3WB0G@53433|Halanaerobiales	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
YHH3_k127_11166224_0	857293.CAAU_0628	6.917e-179	571.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
YHH3_k127_1118595_0	237368.SCABRO_00111	1.986e-244	773.0	COG1331@1|root,COG1331@2|Bacteria,2IX0N@203682|Planctomycetes	203682|Planctomycetes	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
YHH3_k127_1118595_4	138119.DSY4525	0.0001466	52.0	COG2020@1|root,COG2020@2|Bacteria,1UXZ3@1239|Firmicutes,24T5J@186801|Clostridia	186801|Clostridia	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
YHH3_k127_1118595_3	138119.DSY4525	5.748e-05	53.0	COG2020@1|root,COG2020@2|Bacteria,1UXZ3@1239|Firmicutes,24T5J@186801|Clostridia	186801|Clostridia	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
YHH3_k127_1118595_1	1209989.TepiRe1_0599	7.639e-66	234.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia,42F6P@68295|Thermoanaerobacterales	186801|Clostridia	D	CO dehydrogenase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
YHH3_k127_1118595_2	768710.DesyoDRAFT_0766	1.497e-32	138.0	COG0491@1|root,COG0491@2|Bacteria,1V62I@1239|Firmicutes,24I5E@186801|Clostridia,261TE@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_11227846_2	1122134.KB893650_gene226	5.583e-08	59.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XKSQ@135619|Oceanospirillales	135619|Oceanospirillales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_S8
YHH3_k127_11227846_0	673860.AciM339_1556	7.469e-116	383.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,3F2ZN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
YHH3_k127_11227846_3	1380394.JADL01000002_gene1455	3.941e-06	55.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2JQG1@204441|Rhodospirillales	204441|Rhodospirillales	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	-	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
YHH3_k127_11227846_1	485913.Krac_11873	1.514e-46	174.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yxbD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Acetyltransf_1
YHH3_k127_11283191_2	1449126.JQKL01000016_gene2812	2.759e-24	116.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_11283191_1	756499.Desde_0778	1.252e-70	253.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
YHH3_k127_11283191_0	1120979.ATVB01000016_gene570	2.007e-94	321.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4D02Z@85004|Bifidobacteriales	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
YHH3_k127_11283191_4	399550.Smar_1578	3.636e-07	59.0	arCOG03119@1|root,arCOG03119@2157|Archaea,2XQUD@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
YHH3_k127_11283191_3	410359.Pcal_0355	2.692e-13	75.0	COG1503@1|root,arCOG01742@2157|Archaea,2XPRK@28889|Crenarchaeota	28889|Crenarchaeota	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
YHH3_k127_11294123_1	1121024.AUCD01000056_gene1078	1.406e-26	120.0	COG0475@1|root,COG0475@2|Bacteria,1U505@1239|Firmicutes,4HGI1@91061|Bacilli,27G4S@186828|Carnobacteriaceae	91061|Bacilli	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
YHH3_k127_11294123_0	1303518.CCALI_01951	2.22e-57	207.0	COG0177@1|root,COG0177@2|Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
YHH3_k127_11294123_2	304371.MCP_1414	1.113e-14	78.0	COG0426@1|root,arCOG00509@2157|Archaea,2XYDW@28890|Euryarchaeota,2N9PY@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
YHH3_k127_11328652_0	1034943.BN1094_01632	9.821e-43	162.0	COG2324@1|root,COG2324@2|Bacteria,1RA24@1224|Proteobacteria,1SXPG@1236|Gammaproteobacteria,1JCME@118969|Legionellales	118969|Legionellales	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
YHH3_k127_11328652_1	565034.BHWA1_02617	2.882e-27	121.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,2J60I@203691|Spirochaetes	203691|Spirochaetes	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
YHH3_k127_11328652_2	765420.OSCT_2237	6.051e-09	59.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_11340083_0	247490.KSU1_C1273	3.872e-05	46.0	COG3408@1|root,COG3408@2|Bacteria,2IYTX@203682|Planctomycetes	203682|Planctomycetes	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
YHH3_k127_11361670_20	866536.Belba_1184	5.132e-08	61.0	COG0679@1|root,COG0679@2|Bacteria,4NIQF@976|Bacteroidetes,47Q60@768503|Cytophagia	976|Bacteroidetes	S	PFAM Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
YHH3_k127_11361670_16	272844.PAB1356	8.309e-14	83.0	COG0803@1|root,arCOG01005@2157|Archaea,2XVB3@28890|Euryarchaeota,242P1@183968|Thermococci	183968|Thermococci	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
YHH3_k127_11361670_15	348780.NP_0252A	1.725e-14	78.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,23V9I@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	nikR1	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
YHH3_k127_11361670_7	693661.Arcve_1255	1.046e-52	195.0	COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1121 ABC-type Mn Zn transport systems ATPase component	znuC1	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
YHH3_k127_11361670_10	673860.AciM339_0924	8.059e-44	171.0	COG1108@1|root,arCOG01006@2157|Archaea,2XTNB@28890|Euryarchaeota,3F2WR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	ABC 3 transport family	znuB1	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	iAF692.Mbar_A0996	ABC-3
YHH3_k127_11361670_5	186497.PF1571	1.064e-59	215.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,242UI@183968|Thermococci	183968|Thermococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
YHH3_k127_11361670_6	439481.Aboo_0184	9.368e-57	206.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,3F2JN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
YHH3_k127_11361670_8	868131.MSWAN_0460	1.257e-51	193.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,23P36@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
YHH3_k127_11361670_0	1183377.Py04_1444	2.39e-78	269.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
YHH3_k127_11361670_4	1343739.PAP_02075	7.544e-67	237.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
YHH3_k127_11361670_13	342949.PNA2_0520	2.181e-22	101.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
YHH3_k127_11361670_19	694429.Pyrfu_1934	1.533e-11	72.0	COG2136@1|root,arCOG03247@2157|Archaea,2XR1Z@28889|Crenarchaeota	28889|Crenarchaeota	J	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
YHH3_k127_11361670_18	339860.Msp_1255	1.486e-11	68.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y1HA@28890|Euryarchaeota,23P8R@183925|Methanobacteria	183925|Methanobacteria	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
YHH3_k127_11361670_17	593117.TGAM_1495	1.919e-13	74.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,244D1@183968|Thermococci	183968|Thermococci	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044464,GO:0071840	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
YHH3_k127_11361670_9	591019.Shell_1603	2.881e-45	177.0	COG0618@1|root,arCOG01565@2157|Archaea,2XQUB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
YHH3_k127_11361670_3	1343739.PAP_02980	1.294e-67	239.0	COG1122@1|root,arCOG00202@2157|Archaea,2Y7MJ@28890|Euryarchaeota,243GS@183968|Thermococci	183968|Thermococci	P	ATP-binding protein	-	-	-	ko:K16786	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
YHH3_k127_11361670_1	368408.Tpen_0713	5.184e-74	259.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
YHH3_k127_11361670_12	69014.TK0745	2.129e-25	115.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota,2436Y@183968|Thermococci	183968|Thermococci	P	ABC-type cobalt transport system, permease	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
YHH3_k127_11361670_14	70448.Q012I1	1.23e-21	106.0	KOG0274@1|root,KOG0274@2759|Eukaryota,37IQ2@33090|Viridiplantae,34JGQ@3041|Chlorophyta	3041|Chlorophyta	S	WD domain, G-beta repeat	-	-	-	ko:K10260	ko04120,map04120	M00387	-	-	ko00000,ko00001,ko00002,ko04121,ko04131	-	-	-	PQQ_3,U-box,WD40
YHH3_k127_11361670_11	1197130.BAFM01000006_gene1201	1.096e-34	136.0	arCOG09236@1|root,arCOG09236@2157|Archaea,2XYRW@28890|Euryarchaeota,23X7P@183963|Halobacteria	183963|Halobacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11361670_2	1123024.AUII01000021_gene69	1.06e-72	261.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
YHH3_k127_11361670_21	1449976.KALB_7526	0.0007497	46.0	COG1846@1|root,COG1846@2|Bacteria,2GKZA@201174|Actinobacteria,4DXV5@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
YHH3_k127_11378604_0	646529.Desaci_3604	6.746e-70	258.0	COG0477@1|root,COG0477@2|Bacteria,1UNMW@1239|Firmicutes,25ECT@186801|Clostridia,267FI@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
YHH3_k127_11378604_1	1122222.AXWR01000027_gene246	4.264e-27	121.0	2CAQ4@1|root,33YR3@2|Bacteria,1WMW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11378604_2	671065.MetMK1DRAFT_00015820	8.045e-08	56.0	COG0842@1|root,arCOG01465@2157|Archaea,2XQB0@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
YHH3_k127_11379231_0	693661.Arcve_1132	1.523e-147	488.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,246UD@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
YHH3_k127_11379231_5	593750.Metfor_2677	2.872e-35	142.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,2N9JS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
YHH3_k127_11379231_2	1121382.JQKG01000006_gene3528	2.599e-62	226.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
YHH3_k127_11379231_6	1178825.ALIH01000001_gene2373	1.122e-06	57.0	COG0457@1|root,COG0526@1|root,COG0457@2|Bacteria,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1I2TH@117743|Flavobacteriia	976|Bacteroidetes	CO	Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
YHH3_k127_11379231_1	555079.Toce_1753	1.728e-68	240.0	COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
YHH3_k127_11379231_4	309800.C498_01130	1.098e-40	163.0	COG2141@1|root,arCOG02410@2157|Archaea,2XV1C@28890|Euryarchaeota,23UXX@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.14.14.35	ko:K17228	ko00920,map00920	-	R10203	RC02556,RC03080	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
YHH3_k127_11379231_3	144197.XP_008276967.1	6.677e-51	190.0	COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,47ZN8@7711|Chordata,498TD@7742|Vertebrata,4A16Y@7898|Actinopterygii	33208|Metazoa	E	Si dkey-103j14.5	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
YHH3_k127_11390139_7	338966.Ppro_2866	4.717e-21	105.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11390139_2	1236689.MMALV_10340	3.025e-137	459.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,3F2GA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,Fer4_7,PAPS_reduct,PUA
YHH3_k127_11390139_0	760142.Hipma_0789	1.182e-183	591.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2M6D9@213113|Desulfurellales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_11390139_6	1214217.ALNF01000044_gene401	1.031e-73	257.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,1WT0K@1307|Streptococcus suis	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS00835	DeoC
YHH3_k127_11390139_5	1265505.ATUG01000002_gene1734	1.778e-86	301.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2MI42@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
YHH3_k127_11390139_1	186497.PF2015	3.992e-169	558.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
YHH3_k127_11390139_9	456442.Mboo_1535	2.806e-08	58.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
YHH3_k127_11390139_3	224719.Abm4_0226	9.523e-122	404.0	COG1208@1|root,arCOG00668@2157|Archaea,2Y87C@28890|Euryarchaeota,23PZH@183925|Methanobacteria	183925|Methanobacteria	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
YHH3_k127_11390139_4	877455.Metbo_0715	6.064e-93	323.0	COG1032@1|root,arCOG01355@2157|Archaea,2XUPV@28890|Euryarchaeota,23NTW@183925|Methanobacteria	183925|Methanobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
YHH3_k127_11390139_8	342949.PNA2_0184	4.702e-19	90.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
YHH3_k127_11403252_0	565033.GACE_0072	3.527e-31	137.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
YHH3_k127_11403252_1	543632.JOJL01000114_gene1399	0.0004758	52.0	COG4974@1|root,COG4974@2|Bacteria,2I9JH@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
YHH3_k127_1141020_1	1158318.ATXC01000001_gene613	1.984e-37	149.0	COG1688@1|root,COG1688@2|Bacteria,2G41U@200783|Aquificae	200783|Aquificae	L	CRISPR-associated protein (Cas_Cas5)	-	-	-	ko:K19116	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas5d
YHH3_k127_1141020_0	471223.GWCH70_0306	1.231e-56	203.0	COG3649@1|root,COG3649@2|Bacteria,1TQZ8@1239|Firmicutes,4H9KH@91061|Bacilli,1WFB4@129337|Geobacillus	91061|Bacilli	L	CRISPR-associated protein Cas7	csd2	-	-	ko:K19115,ko:K19118	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas7
YHH3_k127_11421896_0	1232437.KL661953_gene2319	4.246e-62	223.0	COG1042@1|root,COG1042@2|Bacteria,1R8Q6@1224|Proteobacteria,42NR2@68525|delta/epsilon subdivisions,2WM2A@28221|Deltaproteobacteria,2MN2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
YHH3_k127_11423508_3	132113.XP_003493204.1	2.675e-14	81.0	COG4886@1|root,KOG0619@2759|Eukaryota,38EBU@33154|Opisthokonta,3BM0W@33208|Metazoa,3D574@33213|Bilateria,41YC3@6656|Arthropoda,3SGB2@50557|Insecta,46ERY@7399|Hymenoptera	33208|Metazoa	T	Leucine rich repeat C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LRR_8,fn3
YHH3_k127_11423508_2	682795.AciX8_0401	6.814e-16	85.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DUF2092,Redoxin
YHH3_k127_11423508_4	1449050.JNLE01000003_gene1278	4.855e-06	57.0	COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,36FFI@31979|Clostridiaceae	186801|Clostridia	O	Cytochrome c biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
YHH3_k127_11423508_0	266117.Rxyl_2910	8.916e-150	495.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
YHH3_k127_11423508_1	525904.Tter_1862	2.324e-52	195.0	COG1478@1|root,COG1478@2|Bacteria,2NQRM@2323|unclassified Bacteria	2|Bacteria	S	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
YHH3_k127_11434221_1	1499680.CCFE01000030_gene3583	7.468e-27	126.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,4HARY@91061|Bacilli	91061|Bacilli	P	PDGLE domain	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
YHH3_k127_11434221_0	339860.Msp_0401	1.393e-54	201.0	COG1122@1|root,arCOG00202@2157|Archaea,2XT28@28890|Euryarchaeota,23PZ7@183925|Methanobacteria	183925|Methanobacteria	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
YHH3_k127_11443357_0	1122169.AREN01000028_gene2929	1.565e-21	98.0	COG2227@1|root,COG2227@2|Bacteria,1R67Q@1224|Proteobacteria,1RVWP@1236|Gammaproteobacteria,1JEPJ@118969|Legionellales	118969|Legionellales	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
YHH3_k127_11484688_0	342949.PNA2_1732	7.278e-33	136.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2430W@183968|Thermococci	183968|Thermococci	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
YHH3_k127_11484688_1	945713.IALB_0605	1.567e-10	65.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
YHH3_k127_11501980_3	237368.SCABRO_03881	4.871e-06	58.0	COG1413@1|root,COG1413@2|Bacteria,2J011@203682|Planctomycetes	203682|Planctomycetes	C	E-Z type HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
YHH3_k127_11501980_2	647113.Metok_1476	7.265e-23	103.0	COG0375@1|root,arCOG04426@2157|Archaea,2XY46@28890|Euryarchaeota,23QZX@183939|Methanococci	183939|Methanococci	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
YHH3_k127_11501980_1	797114.C475_16009	4.814e-27	114.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23W98@183963|Halobacteria	183963|Halobacteria	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
YHH3_k127_11501980_0	1220534.B655_2351	2.996e-98	333.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,23NWV@183925|Methanobacteria	183925|Methanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
YHH3_k127_11513568_2	224325.AF_0367	2.752e-20	92.0	COG0477@1|root,arCOG00147@2157|Archaea,2XTS8@28890|Euryarchaeota,246N5@183980|Archaeoglobi	183980|Archaeoglobi	G	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
YHH3_k127_11513568_0	370438.PTH_2131	2.337e-259	816.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
YHH3_k127_11513568_1	1196323.ALKF01000153_gene992	4.421e-59	221.0	COG4188@1|root,COG4188@2|Bacteria,1V2UM@1239|Firmicutes,4HV9C@91061|Bacilli,2754C@186822|Paenibacillaceae	91061|Bacilli	S	Chlorophyllase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
YHH3_k127_11531242_0	880073.Calab_0272	1.729e-12	79.0	COG1649@1|root,COG3023@1|root,COG3391@1|root,COG4412@1|root,COG1649@2|Bacteria,COG3023@2|Bacteria,COG3391@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.2.1.20,3.4.17.22,3.5.1.28	ko:K01187,ko:K01448,ko:K07752	ko00052,ko00500,ko01100,ko01503,map00052,map00500,map01100,map01503	M00727	R00028,R00801,R00802,R04112,R06087,R06088	RC00028,RC00049,RC00064,RC00077,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036	-	GH31	-	Amidase_2
YHH3_k127_11533328_0	880073.Calab_1834	9.964e-11	73.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
YHH3_k127_11537084_0	29540.C481_10510	0.0002006	48.0	arCOG09068@1|root,arCOG09068@2157|Archaea,2XTH4@28890|Euryarchaeota,23T3U@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11543923_1	1094980.Mpsy_2085	4.185e-100	344.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,2N94C@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
YHH3_k127_11543923_0	529709.PYCH_10270	2.691e-119	402.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,242YE@183968|Thermococci	183968|Thermococci	J	Phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
YHH3_k127_11543923_3	8049.ENSGMOP00000013973	6.32e-28	121.0	KOG0092@1|root,KOG0092@2759|Eukaryota,38BZN@33154|Opisthokonta,3BF7P@33208|Metazoa,3CXE3@33213|Bilateria,480UH@7711|Chordata,48X28@7742|Vertebrata,49XGW@7898|Actinopterygii	33208|Metazoa	U	RAB22A, member RAS oncogene family	RAB22A	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005856,GO:0005886,GO:0006810,GO:0006897,GO:0006996,GO:0007032,GO:0008150,GO:0009987,GO:0010256,GO:0012505,GO:0015629,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030139,GO:0031410,GO:0031982,GO:0032535,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045335,GO:0051179,GO:0051234,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066,GO:0097159,GO:0097367,GO:0097494,GO:0097708,GO:0098657,GO:1901265,GO:1901363	-	ko:K07891	ko04144,map04144	-	-	-	ko00000,ko00001,ko04031,ko04131	-	-	-	Ras
YHH3_k127_11543923_5	590998.Celf_2293	4.661e-15	80.0	COG2905@1|root,COG2905@2|Bacteria,2HY5B@201174|Actinobacteria,4F319@85016|Cellulomonadaceae	201174|Actinobacteria	T	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
YHH3_k127_11543923_4	8479.XP_005290983.1	6.286e-25	111.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa,3CXE2@33213|Bilateria,48810@7711|Chordata,48YH9@7742|Vertebrata,4CFT3@8459|Testudines	33208|Metazoa	U	RAB18, member RAS oncogene family	RAB18	GO:0000166,GO:0001654,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006810,GO:0006887,GO:0006913,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032940,GO:0034389,GO:0035556,GO:0036094,GO:0036230,GO:0042119,GO:0042175,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098827,GO:0099503,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
YHH3_k127_11543923_2	1094508.Tsac_0512	1.878e-36	141.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,42FKX@68295|Thermoanaerobacterales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
YHH3_k127_11552220_1	386456.JQKN01000001_gene1892	1.019e-116	393.0	COG0479@1|root,arCOG00963@2157|Archaea,2Y85K@28890|Euryarchaeota,23PZE@183925|Methanobacteria	183925|Methanobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
YHH3_k127_11552220_0	1220534.B655_1070	3.16e-154	504.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	sdhA	-	1.3.4.1	ko:K18209	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
YHH3_k127_11552220_3	673860.AciM339_1147	1.266e-68	238.0	COG1838@1|root,arCOG04406@2157|Archaea,2XXBQ@28890|Euryarchaeota,3F2QU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
YHH3_k127_11552220_2	439481.Aboo_0990	2.491e-88	301.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,3F2K1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
YHH3_k127_11552220_7	756883.Halar_2857	1.073e-05	53.0	COG1989@1|root,arCOG02298@2157|Archaea	2157|Archaea	NOU	Peptidase A24A, prepilin type IV	pibD	-	3.4.23.43,3.4.23.52	ko:K02278,ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
YHH3_k127_11552220_4	1343739.PAP_05715	4.051e-61	218.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
YHH3_k127_11552220_6	186497.PF0864	4.133e-15	82.0	COG1522@1|root,arCOG01585@2157|Archaea,2Y2M7@28890|Euryarchaeota,24476@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH3_k127_11552220_5	342949.PNA2_0051	1.795e-45	175.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
YHH3_k127_11556666_0	1227487.C474_00375	4.049e-25	106.0	COG4799@1|root,arCOG02705@2157|Archaea,2XSVM@28890|Euryarchaeota,23T6H@183963|Halobacteria	183963|Halobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB2	GO:0003674,GO:0003824,GO:0004658,GO:0016421,GO:0016874,GO:0016885	2.1.3.15,6.4.1.2,6.4.1.3	ko:K19312	ko00280,ko00630,ko00640,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01120,map01130,map01200	M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
YHH3_k127_11556666_4	1132509.C447_04141	1.736e-05	49.0	arCOG08550@1|root,arCOG08550@2157|Archaea,2Y049@28890|Euryarchaeota,23XNK@183963|Halobacteria	183963|Halobacteria	S	Pfam:DUF217	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
YHH3_k127_11556666_1	1057002.KB905370_gene3595	2.647e-09	64.0	COG1487@1|root,COG1487@2|Bacteria,1NAZ2@1224|Proteobacteria,2UJ5N@28211|Alphaproteobacteria,4BG1M@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
YHH3_k127_11556666_3	273057.SSO2463	4.933e-06	49.0	COG4799@1|root,arCOG02705@2157|Archaea,2XPKJ@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM carboxyl transferase	pccB	-	2.1.3.15,6.4.1.2,6.4.1.3	ko:K15036	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01130,map01200	M00375,M00741	R00742,R01859,R04386	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
YHH3_k127_11556666_2	1220534.B655_1002	1.647e-08	67.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
YHH3_k127_11564112_1	573063.Metin_0388	3.473e-27	117.0	COG3294@1|root,arCOG04230@2157|Archaea,2XURZ@28890|Euryarchaeota	28890|Euryarchaeota	S	Phosphohydrolase	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
YHH3_k127_11564112_7	243232.MJ_0207	0.0008665	48.0	arCOG07626@1|root,arCOG07626@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11564112_2	51511.ENSCSAVP00000017564	6.998e-15	81.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa,3CXE2@33213|Bilateria,48810@7711|Chordata	33208|Metazoa	U	lipid droplet organization	RAB18	GO:0000166,GO:0001654,GO:0001775,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006810,GO:0006887,GO:0006913,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032940,GO:0034389,GO:0035556,GO:0036094,GO:0036230,GO:0042119,GO:0042175,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098827,GO:0099503,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
YHH3_k127_11564112_5	1300150.EMQU_2124	2.118e-10	67.0	COG0454@1|root,COG0456@2|Bacteria,1V7GR@1239|Firmicutes,4HJ11@91061|Bacilli,4B0FF@81852|Enterococcaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
YHH3_k127_11564112_0	743719.PaelaDRAFT_3980	3.727e-47	175.0	COG0454@1|root,COG0456@2|Bacteria,1V2CK@1239|Firmicutes,4HGP5@91061|Bacilli,26WI0@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yyaR	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_11564112_3	767817.Desgi_0300	1.608e-13	81.0	COG2041@1|root,COG5492@1|root,COG2041@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	1.1.1.169,3.2.1.4,3.4.17.14	ko:K00077,ko:K01179,ko:K07260,ko:K13735	ko00500,ko00550,ko00770,ko01100,ko01110,ko01502,ko02020,ko05100,map00500,map00550,map00770,map01100,map01110,map01502,map02020,map05100	M00119,M00651	R02472,R06200,R11307,R11308	RC00726	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	GH5,GH9	-	Big_1,Big_2,Fn3_assoc,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH
YHH3_k127_11564112_6	468059.AUHA01000005_gene2452	0.0003421	53.0	COG0477@1|root,COG2814@2|Bacteria,4NEN9@976|Bacteroidetes,1IR8C@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_11564112_4	579137.Metvu_1486	5.26e-11	64.0	COG1908@1|root,arCOG02475@2157|Archaea,2XXAU@28890|Euryarchaeota,23QYD@183939|Methanococci	183939|Methanococci	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
YHH3_k127_11565925_0	1121286.AUMT01000003_gene2261	1.672e-100	344.0	COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,1HWUA@117743|Flavobacteriia,3ZNZT@59732|Chryseobacterium	976|Bacteroidetes	E	Catalyzes the hydrolysis of Xaa-His dipeptides	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
YHH3_k127_11565925_1	1120971.AUCA01000012_gene2544	9.516e-20	96.0	COG0671@1|root,COG0671@2|Bacteria,1V01Y@1239|Firmicutes,4HH2U@91061|Bacilli	91061|Bacilli	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
YHH3_k127_11565925_2	1304885.AUEY01000032_gene1991	6.569e-08	55.0	COG1578@1|root,COG1578@2|Bacteria,1R50K@1224|Proteobacteria,42Q0S@68525|delta/epsilon subdivisions,2WJ5M@28221|Deltaproteobacteria,2MIQ5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF89	-	-	-	-	-	-	-	-	-	-	-	-	DUF89
YHH3_k127_11570359_0	398512.JQKC01000044_gene1246	1.029e-35	142.0	28PJ3@1|root,2ZC8W@2|Bacteria,1V220@1239|Firmicutes,24IPD@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11570359_1	323259.Mhun_1747	4.68e-22	97.0	COG1598@1|root,arCOG02412@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11570359_2	565033.GACE_1252	4.554e-20	92.0	arCOG03086@1|root,arCOG03086@2157|Archaea,2Y6GQ@28890|Euryarchaeota,247DW@183980|Archaeoglobi	183980|Archaeoglobi	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
YHH3_k127_11570359_4	694430.Natoc_3222	4.945e-06	53.0	arCOG08146@1|root,arCOG08146@2157|Archaea,2XZG5@28890|Euryarchaeota,23X98@183963|Halobacteria	183963|Halobacteria	K	Pfam:DUF217	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
YHH3_k127_11570359_3	797299.HALLA_20355	3.859e-15	80.0	COG1487@1|root,arCOG02219@2157|Archaea,2XX7I@28890|Euryarchaeota,23VMN@183963|Halobacteria	183963|Halobacteria	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
YHH3_k127_11576565_12	1163730.FFONT_0433	5.035e-49	182.0	COG1890@1|root,arCOG04186@2157|Archaea,2XPNX@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
YHH3_k127_11576565_22	1163730.FFONT_0844	1.02e-11	70.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
YHH3_k127_11576565_19	415426.Hbut_1631	6.609e-18	86.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
YHH3_k127_11576565_8	186497.PF0022	2.876e-69	254.0	COG1530@1|root,arCOG04307@2157|Archaea,2XUGB@28890|Euryarchaeota,243F3@183968|Thermococci	183968|Thermococci	J	Binds to RNA in loop regions with AU-rich sequences	aubA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K22469	-	-	-	-	ko00000,ko03009	-	-	-	DUF402,RNase_E_G
YHH3_k127_11576565_24	1365176.N186_03530	2.908e-10	72.0	COG0608@1|root,arCOG00427@2157|Archaea,2XQMC@28889|Crenarchaeota	28889|Crenarchaeota	L	Phosphoesterase, RecJ domain protein	-	-	-	ko:K07462,ko:K07463	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHHA1
YHH3_k127_11576565_14	579137.Metvu_1548	5.74e-44	165.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,23QST@183939|Methanococci	183939|Methanococci	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
YHH3_k127_11576565_15	69014.TK0679	3.264e-43	165.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
YHH3_k127_11576565_3	386456.JQKN01000020_gene1319	4.308e-115	379.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
YHH3_k127_11576565_21	1459636.NTE_01725	1.958e-12	69.0	COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
YHH3_k127_11576565_5	304371.MCP_0137	2.017e-91	325.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
YHH3_k127_11576565_20	399549.Msed_0229	1.436e-14	77.0	COG0640@1|root,arCOG01679@2157|Archaea,2XR0G@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
YHH3_k127_11576565_11	673860.AciM339_1197	1.011e-49	196.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,3F30Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
YHH3_k127_11576565_2	511680.BUTYVIB_02309	2.973e-163	531.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,4BY35@830|Butyrivibrio	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
YHH3_k127_11576565_18	1125863.JAFN01000001_gene3506	2.213e-29	124.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
YHH3_k127_11576565_7	1229909.NSED_09080	2.899e-76	272.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
YHH3_k127_11576565_9	69014.TK1688	4.178e-65	230.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
YHH3_k127_11576565_10	930945.SiRe_1049	2.01e-58	212.0	COG1100@1|root,arCOG01225@2157|Archaea,2XQ2Q@28889|Crenarchaeota	28889|Crenarchaeota	S	ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
YHH3_k127_11576565_17	386456.JQKN01000002_gene2681	3.091e-38	157.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
YHH3_k127_11576565_23	1365176.N186_04650	8.687e-11	68.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
YHH3_k127_11576565_13	694429.Pyrfu_0043	1.277e-47	176.0	COG0237@1|root,arCOG01045@2157|Archaea,2XQTJ@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,AAA_18
YHH3_k127_11576565_4	386456.JQKN01000001_gene2179	1.528e-94	322.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,23NRE@183925|Methanobacteria	183925|Methanobacteria	O	AAA ATPase	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
YHH3_k127_11576565_16	415426.Hbut_0388	5.057e-41	157.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
YHH3_k127_11576565_6	589924.Ferp_0652	3.752e-82	286.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
YHH3_k127_11576565_0	351160.RCIX575	2.298e-175	575.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
YHH3_k127_11576565_1	768672.Desfe_0822	8.593e-169	553.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
YHH3_k127_11637634_5	631362.Thi970DRAFT_03417	8.954e-06	52.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1S7G4@1236|Gammaproteobacteria,1WYM8@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
YHH3_k127_11637634_6	273068.TTE0861	0.0002902	53.0	COG1404@1|root,COG1404@2|Bacteria,1UHYW@1239|Firmicutes,25E7G@186801|Clostridia,42JFN@68295|Thermoanaerobacterales	186801|Clostridia	O	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY,SLH
YHH3_k127_11637634_2	1459636.NTE_01818	4.888e-20	95.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
YHH3_k127_11637634_1	1385511.N783_03265	6.81e-34	140.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,4HAZA@91061|Bacilli	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,PA,PPC,Peptidase_S8,SLH
YHH3_k127_11637634_3	106582.XP_004552957.1	6.165e-16	85.0	KOG0443@1|root,KOG0443@2759|Eukaryota,38BDF@33154|Opisthokonta,3B9RZ@33208|Metazoa,3CVSD@33213|Bilateria,483GQ@7711|Chordata,494JV@7742|Vertebrata,4A0KH@7898|Actinopterygii	33208|Metazoa	Z	Scinderin like	-	-	-	ko:K05761,ko:K05768,ko:K08017	ko04666,ko04810,ko05203,map04666,map04810,map05203	-	-	-	ko00000,ko00001,ko04147,ko04812	-	-	-	Gelsolin,VHP
YHH3_k127_11637634_0	593750.Metfor_2676	7.09e-70	248.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
YHH3_k127_11637634_4	96561.Dole_2064	5.648e-15	77.0	COG1148@1|root,COG1148@2|Bacteria,1N26U@1224|Proteobacteria,43BRJ@68525|delta/epsilon subdivisions,2X72E@28221|Deltaproteobacteria,2MPJ6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_11719708_0	68170.KL590490_gene1267	1.492e-28	132.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
YHH3_k127_11746093_3	445335.CBN_2743	8.957e-16	83.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,36DM6@31979|Clostridiaceae	186801|Clostridia	P	Transporter, CPA2 family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
YHH3_k127_11746093_2	309799.DICTH_1532	3.21e-23	109.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
YHH3_k127_11746093_0	933262.AXAM01000035_gene2154	5.654e-53	199.0	2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria,2MNT8@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11746093_1	649638.Trad_1166	6e-38	153.0	COG1030@1|root,COG1030@2|Bacteria,1WKAY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11747459_1	269797.Mbar_A3530	3.047e-50	196.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_11747459_0	374847.Kcr_1128	1e-78	280.0	COG1530@1|root,arCOG00321@2157|Archaea	2157|Archaea	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_11747459_2	555088.DealDRAFT_0112	6.286e-26	111.0	2FJYI@1|root,34BKW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11747459_3	521045.Kole_0126	2.792e-12	68.0	COG0765@1|root,COG0765@2|Bacteria,2GCAY@200918|Thermotogae	200918|Thermotogae	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
YHH3_k127_11753135_0	1365176.N186_01885	1.017e-27	117.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
YHH3_k127_11753135_1	301.JNHE01000017_gene4680	2.113e-08	62.0	2AIJ7@1|root,3191B@2|Bacteria,1QF4A@1224|Proteobacteria,1TC6W@1236|Gammaproteobacteria,1YJZ4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4406)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4406
YHH3_k127_11753135_2	304371.MCP_1198	4.398e-06	59.0	COG2202@1|root,arCOG02329@1|root,arCOG02329@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg
YHH3_k127_11779152_0	1449126.JQKL01000002_gene1549	5.85e-46	174.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia	2|Bacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
YHH3_k127_11779152_1	518766.Rmar_2578	1.03e-20	97.0	COG1246@1|root,COG1246@2|Bacteria,4NVX0@976|Bacteroidetes	976|Bacteroidetes	E	COGs COG1246 N-acetylglutamate synthase and related acetyltransferase	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
YHH3_k127_11779152_2	926550.CLDAP_07730	4.923e-06	53.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	MA20_10010	-	-	-	-	-	-	-	-	-	-	-	TetR_N
YHH3_k127_11815799_2	529709.PYCH_01970	8.952e-21	98.0	arCOG04797@1|root,arCOG04797@2157|Archaea,2XZMY@28890|Euryarchaeota,24531@183968|Thermococci	183968|Thermococci	S	retrograde transport, endosome to Golgi	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11815799_1	648996.Theam_1336	6.064e-32	128.0	2E4R1@1|root,32ZJK@2|Bacteria,2G53K@200783|Aquificae	200783|Aquificae	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
YHH3_k127_11815799_0	290318.Cvib_1206	6.436e-52	192.0	COG0277@1|root,COG0277@2|Bacteria,1FDCI@1090|Chlorobi	1090|Chlorobi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_11825888_6	1244531.CIG1485E_0932	6.997e-05	49.0	COG0697@1|root,COG0697@2|Bacteria,1NCEQ@1224|Proteobacteria,42Q1M@68525|delta/epsilon subdivisions,2YNCR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH3_k127_11825888_5	368408.Tpen_1832	3.118e-09	68.0	COG0697@1|root,arCOG00272@2157|Archaea	2157|Archaea	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
YHH3_k127_11825888_0	644281.MFS40622_1299	1.108e-51	194.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
YHH3_k127_11825888_1	643648.Slip_2102	1.157e-46	173.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia,42KMI@68298|Syntrophomonadaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6
YHH3_k127_11825888_2	693661.Arcve_0808	6.123e-41	163.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,245QK@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
YHH3_k127_11825888_4	28042.GU90_13030	8.055e-12	71.0	COG2164@1|root,COG2164@2|Bacteria,2I8JP@201174|Actinobacteria,4E0QF@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF3830)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3830
YHH3_k127_11825888_3	768672.Desfe_0736	1.566e-26	120.0	COG0006@1|root,arCOG01000@2157|Archaea,2XQD7@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the peptidase M24B family	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
YHH3_k127_11856304_1	865861.AZSU01000003_gene2199	2.34e-119	392.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,36FTT@31979|Clostridiaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
YHH3_k127_11856304_0	1047013.AQSP01000134_gene1369	3.768e-156	507.0	COG0403@1|root,COG0403@2|Bacteria,2NQS4@2323|unclassified Bacteria	2|Bacteria	E	Glycine cleavage system P-protein	gcvPA	-	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
YHH3_k127_11856304_2	273068.TTE1234	5.326e-59	217.0	COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia,42G7Z@68295|Thermoanaerobacterales	186801|Clostridia	C	Dihydrodipicolinate reductase, N-terminus	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
YHH3_k127_11901652_0	591019.Shell_0582	3.904e-126	417.0	COG0402@1|root,arCOG00695@2157|Archaea,2XPV1@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
YHH3_k127_11902094_0	1033806.HTIA_1955	9.341e-22	99.0	arCOG14997@1|root,arCOG14997@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11902094_2	43228.XP_007734262.1	1.176e-06	56.0	COG0468@1|root,KOG1433@2759|Eukaryota,38CS4@33154|Opisthokonta,3NU4I@4751|Fungi,3QMZH@4890|Ascomycota,20BB6@147545|Eurotiomycetes,3MUHD@451870|Chaetothyriomycetidae	4751|Fungi	L	Required both for recombination and for the repair of DNA damage caused by X-rays	rhp51	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000278,GO:0000280,GO:0000400,GO:0000709,GO:0000722,GO:0000723,GO:0000724,GO:0000725,GO:0000730,GO:0000775,GO:0000785,GO:0000790,GO:0000793,GO:0000794,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006275,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006325,GO:0006342,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0007530,GO:0007531,GO:0007533,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010212,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030491,GO:0030554,GO:0030702,GO:0031297,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032200,GO:0032502,GO:0032505,GO:0032553,GO:0032555,GO:0032559,GO:0033170,GO:0033260,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0035639,GO:0035825,GO:0035861,GO:0036094,GO:0036297,GO:0040029,GO:0042148,GO:0042592,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0044877,GO:0045003,GO:0045005,GO:0045165,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0048285,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051716,GO:0060249,GO:0060255,GO:0061806,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0070013,GO:0070192,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090329,GO:0090734,GO:0090735,GO:0097159,GO:0097367,GO:0098687,GO:0110026,GO:0110027,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1902298,GO:1902679,GO:1902969,GO:1903046,GO:1903047,GO:1903506,GO:1903507,GO:1905334,GO:1990426,GO:1990505,GO:1990918,GO:2000104,GO:2000112,GO:2000113,GO:2001141	-	ko:K04482	ko03440,ko03460,ko05200,ko05212,map03440,map03460,map05200,map05212	-	-	-	ko00000,ko00001,ko03400,ko04121,ko04131	-	-	-	HHH_5,Rad51
YHH3_k127_11911520_0	1379698.RBG1_1C00001G1510	1.632e-56	211.0	COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldE2	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_11922427_0	1163409.UUA_12860	1.159e-08	68.0	COG1361@1|root,COG1572@1|root,COG2234@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,COG2234@2|Bacteria,COG4733@2|Bacteria,1N837@1224|Proteobacteria,1RZXI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11969157_1	593750.Metfor_2772	3.519e-63	224.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N92S@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	iAF692.Mbar_A1452	FeoB_C,FeoB_N,Gate
YHH3_k127_11969157_4	644281.MFS40622_1542	9.18e-06	54.0	arCOG04938@1|root,arCOG04938@2157|Archaea,2XZYR@28890|Euryarchaeota,23RR4@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_11969157_3	439481.Aboo_1105	2.648e-22	101.0	COG1321@1|root,arCOG02100@2157|Archaea,2XZV0@28890|Euryarchaeota,3F2W5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	PFAM iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
YHH3_k127_11969157_5	383372.Rcas_3603	0.0003508	50.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
YHH3_k127_11969157_0	580327.Tthe_2090	6.859e-196	631.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,42F6C@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
YHH3_k127_11969157_2	296587.XP_002499438.1	1.332e-23	108.0	297V5@1|root,2REVD@2759|Eukaryota,389P5@33090|Viridiplantae,34IW7@3041|Chlorophyta	3041|Chlorophyta	S	WD repeat protein 35. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12018027_1	931276.Cspa_c14350	2.703e-35	153.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,36EUU@31979|Clostridiaceae	186801|Clostridia	E	family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_12018027_0	1118054.CAGW01000024_gene451	3.223e-69	243.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,26SYE@186822|Paenibacillaceae	91061|Bacilli	E	peptidase M20	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
YHH3_k127_12031453_1	521045.Kole_0124	1.178e-30	128.0	COG0765@1|root,COG0765@2|Bacteria,2GCTA@200918|Thermotogae	200918|Thermotogae	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
YHH3_k127_12031453_0	634497.HAH_2280	2.451e-87	295.0	COG1126@1|root,arCOG00923@2157|Archaea,2XVB5@28890|Euryarchaeota,23SDF@183963|Halobacteria	183963|Halobacteria	E	COG1126 ABC-type polar amino acid transport system, ATPase component	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
YHH3_k127_12031453_2	570952.ATVH01000001_gene900	1.563e-26	115.0	COG0765@1|root,COG0765@2|Bacteria,1QN80@1224|Proteobacteria,2VFKB@28211|Alphaproteobacteria,2JYMF@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
YHH3_k127_12035894_0	335543.Sfum_0824	3.287e-233	754.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MQTQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K15022	ko00680,ko00720,ko01100,ko01120,ko01200,map00680,map00720,map01100,map01120,map01200	M00356,M00357,M00377,M00563,M00567	R00134,R04540,R11928,R11931,R11943,R11944	RC00011,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
YHH3_k127_12035894_1	264732.Moth_1193	3.01e-32	138.0	COG1908@1|root,COG1908@2|Bacteria,1V638@1239|Firmicutes,24J0E@186801|Clostridia,42IDY@68295|Thermoanaerobacterales	186801|Clostridia	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
YHH3_k127_12035894_2	485915.Dret_0420	8.578e-13	71.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RK0@68525|delta/epsilon subdivisions,2WNZZ@28221|Deltaproteobacteria,2MGM3@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
YHH3_k127_1204689_1	323259.Mhun_0597	9.611e-40	160.0	COG3291@1|root,arCOG02559@1|root,arCOG06792@1|root,arCOG02508@2157|Archaea,arCOG02559@2157|Archaea,arCOG06792@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
YHH3_k127_1204689_0	443254.Marpi_1626	2.591e-115	383.0	COG0156@1|root,COG0156@2|Bacteria,2GCC8@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
YHH3_k127_1204689_2	1120953.AUBH01000005_gene2373	3.183e-22	105.0	28U7J@1|root,2ZGD7@2|Bacteria,1PA60@1224|Proteobacteria,1SUS6@1236|Gammaproteobacteria,46CC3@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12052230_1	439235.Dalk_2999	2.403e-10	67.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,42RU9@68525|delta/epsilon subdivisions,2WNP7@28221|Deltaproteobacteria,2MJU6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
YHH3_k127_12052230_0	883.DvMF_0588	4.939e-21	96.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,42U9T@68525|delta/epsilon subdivisions,2WQPQ@28221|Deltaproteobacteria,2MCJT@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
YHH3_k127_12159561_2	56110.Oscil6304_3816	7.263e-10	66.0	COG0515@1|root,COG0652@1|root,COG0515@2|Bacteria,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
YHH3_k127_12159561_1	67332.FM21_16340	3.808e-29	124.0	COG0500@1|root,COG2226@2|Bacteria,2GKPQ@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
YHH3_k127_12159561_0	925409.KI911562_gene2239	1.264e-89	303.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,1IPUF@117747|Sphingobacteriia	976|Bacteroidetes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
YHH3_k127_12184136_0	309807.SRU_0049	1.891e-65	231.0	COG2309@1|root,COG2309@2|Bacteria,4NRU3@976|Bacteroidetes	976|Bacteroidetes	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
YHH3_k127_12184136_1	797302.Halru_3057	2.443e-38	150.0	COG2309@1|root,arCOG01889@2157|Archaea,2Y8FU@28890|Euryarchaeota,23SC8@183963|Halobacteria	183963|Halobacteria	E	Leucyl aminopeptidase (Aminopeptidase t)	pepB3	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
YHH3_k127_12188844_1	1125863.JAFN01000001_gene2593	1.45e-19	94.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
YHH3_k127_12188844_0	6183.Smp_014660.2	1.152e-27	125.0	KOG0078@1|root,KOG0078@2759|Eukaryota,38EHU@33154|Opisthokonta,3B9UK@33208|Metazoa,3CTWJ@33213|Bilateria	33208|Metazoa	U	establishment of protein localization to endoplasmic reticulum membrane	RAB10	GO:0000003,GO:0000166,GO:0000902,GO:0000904,GO:0001738,GO:0001775,GO:0001881,GO:0001882,GO:0001883,GO:0002009,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002790,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005797,GO:0005802,GO:0005829,GO:0005886,GO:0005929,GO:0006810,GO:0006886,GO:0006887,GO:0006892,GO:0006893,GO:0006904,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007163,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007295,GO:0007399,GO:0007405,GO:0007409,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008283,GO:0008356,GO:0009306,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010008,GO:0010033,GO:0010243,GO:0010256,GO:0010511,GO:0010512,GO:0010563,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016328,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0017145,GO:0017157,GO:0019001,GO:0019003,GO:0019216,GO:0019220,GO:0019222,GO:0019882,GO:0019904,GO:0019953,GO:0022008,GO:0022406,GO:0022412,GO:0022414,GO:0023051,GO:0023052,GO:0030010,GO:0030030,GO:0030133,GO:0030141,GO:0030154,GO:0030182,GO:0030198,GO:0030424,GO:0030659,GO:0030667,GO:0030855,GO:0030859,GO:0031045,GO:0031090,GO:0031175,GO:0031254,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031489,GO:0031982,GO:0031984,GO:0031985,GO:0032456,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032593,GO:0032794,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032990,GO:0033036,GO:0033365,GO:0034613,GO:0035556,GO:0035639,GO:0036094,GO:0036230,GO:0036445,GO:0036477,GO:0040007,GO:0042119,GO:0042175,GO:0042221,GO:0042886,GO:0042995,GO:0043001,GO:0043005,GO:0043025,GO:0043062,GO:0043112,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0043434,GO:0044237,GO:0044260,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045055,GO:0045165,GO:0045175,GO:0045178,GO:0045184,GO:0045196,GO:0045200,GO:0045321,GO:0045833,GO:0045936,GO:0046677,GO:0046890,GO:0046903,GO:0046907,GO:0048103,GO:0048193,GO:0048278,GO:0048468,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048523,GO:0048589,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051021,GO:0051046,GO:0051049,GO:0051055,GO:0051128,GO:0051174,GO:0051179,GO:0051234,GO:0051301,GO:0051640,GO:0051641,GO:0051649,GO:0051704,GO:0051716,GO:0055037,GO:0055038,GO:0055057,GO:0055059,GO:0060429,GO:0060627,GO:0061351,GO:0061564,GO:0061864,GO:0061951,GO:0065007,GO:0070201,GO:0070278,GO:0070382,GO:0070727,GO:0070887,GO:0070972,GO:0071071,GO:0071072,GO:0071236,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071532,GO:0071702,GO:0071704,GO:0071705,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0072089,GO:0072594,GO:0072599,GO:0072657,GO:0072659,GO:0080090,GO:0090150,GO:0097051,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098588,GO:0098722,GO:0098791,GO:0098805,GO:0098827,GO:0098876,GO:0099503,GO:0110010,GO:0110011,GO:0120025,GO:0120036,GO:0120039,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902646,GO:1902647,GO:1903053,GO:1903361,GO:1903530,GO:1903725,GO:1903726,GO:1904951,GO:1990778	-	ko:K07902,ko:K07903	ko04144,ko04152,ko04530,map04144,map04152,map04530	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_1219329_0	715451.ambt_02580	2.016e-09	71.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	-
YHH3_k127_12203158_0	926550.CLDAP_28350	1.54e-81	292.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
YHH3_k127_12210336_1	56110.Oscil6304_3444	2.64e-08	64.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1JX@1117|Cyanobacteria,1H9C6@1150|Oscillatoriales	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7
YHH3_k127_12210336_0	693661.Arcve_1631	8.558e-27	118.0	COG0467@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,2XXH5@28890|Euryarchaeota	28890|Euryarchaeota	T	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
YHH3_k127_12210336_2	644281.MFS40622_0066	4.277e-08	57.0	COG0309@1|root,arCOG00636@2157|Archaea,2Y8GC@28890|Euryarchaeota,23RWJ@183939|Methanococci	183939|Methanococci	O	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
YHH3_k127_12236886_3	671143.DAMO_2920	7.631e-08	61.0	2DRSH@1|root,33CVS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12236886_0	579137.Metvu_1488	7.018e-133	436.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23QHR@183939|Methanococci	183939|Methanococci	C	PFAM Nickel-dependent hydrogenase, large subunit	vhuA	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
YHH3_k127_12236886_1	523845.AQXV01000050_gene1004	1.66e-57	214.0	COG1941@1|root,arCOG02472@2157|Archaea,2XVJ0@28890|Euryarchaeota,23QEJ@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	vhuG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
YHH3_k127_12236886_2	1499967.BAYZ01000171_gene5568	1.063e-47	173.0	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	hdrG	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
YHH3_k127_1228045_1	1125863.JAFN01000001_gene1335	9.957e-31	124.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
YHH3_k127_1228045_0	1121422.AUMW01000012_gene2931	1.762e-64	232.0	COG1788@1|root,COG1788@2|Bacteria,1UYH2@1239|Firmicutes,24CPB@186801|Clostridia	186801|Clostridia	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
YHH3_k127_1228045_5	4536.ONIVA04G23980.1	0.0002609	48.0	KOG1513@1|root,KOG1513@2759|Eukaryota,389EY@33090|Viridiplantae,3GYIH@35493|Streptophyta,3M36R@4447|Liliopsida,3I86D@38820|Poales	35493|Streptophyta	S	Plant transposase (Ptta/En/Spm family)	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_24
YHH3_k127_1228045_2	273075.Ta0785	4.078e-09	67.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y1QQ@28890|Euryarchaeota,242HN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
YHH3_k127_1228045_4	273075.Ta0785	8.313e-05	52.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y1QQ@28890|Euryarchaeota,242HN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
YHH3_k127_1228045_3	479437.Elen_0349	7.225e-06	49.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
YHH3_k127_12284597_2	573063.Metin_1190	2.38e-49	183.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23QK3@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
YHH3_k127_12284597_0	386456.JQKN01000019_gene1316	2.15e-232	735.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
YHH3_k127_12284597_7	342949.PNA2_1854	5.854e-33	149.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,243RC@183968|Thermococci	183968|Thermococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
YHH3_k127_12284597_8	521011.Mpal_0397	6.093e-30	126.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,2N9WM@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
YHH3_k127_12284597_11	1459636.NTE_02161	1.388e-15	79.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
YHH3_k127_12284597_10	386456.JQKN01000002_gene2403	4.814e-18	85.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
YHH3_k127_12284597_3	1366046.HIMB11_01804	4.266e-46	171.0	2CHCP@1|root,32BUX@2|Bacteria,1PWZB@1224|Proteobacteria,2V7CQ@28211|Alphaproteobacteria,3ZINV@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12284597_13	575588.ACPN01000028_gene722	0.000799	49.0	COG0739@1|root,COG0739@2|Bacteria,1R9V0@1224|Proteobacteria,1RZIG@1236|Gammaproteobacteria,3NNCI@468|Moraxellaceae	1236|Gammaproteobacteria	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
YHH3_k127_12284597_4	667014.Thein_2107	1.297e-34	136.0	COG0437@1|root,COG0437@2|Bacteria,2GIJ6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_12284597_1	521460.Athe_0821	5.827e-168	545.0	COG2414@1|root,COG2414@2|Bacteria,1TT8D@1239|Firmicutes,24A40@186801|Clostridia,42HWM@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_12284597_5	702450.CUW_0676	2.691e-34	140.0	COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,3VRME@526524|Erysipelotrichia	526524|Erysipelotrichia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2
YHH3_k127_12284597_6	1200792.AKYF01000010_gene2058	1.662e-33	146.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4HC54@91061|Bacilli,2758S@186822|Paenibacillaceae	91061|Bacilli	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
YHH3_k127_12284597_9	41431.PCC8801_1300	2.291e-25	113.0	COG0457@1|root,COG0457@2|Bacteria,1GIT8@1117|Cyanobacteria,3KHZU@43988|Cyanothece	1117|Cyanobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_2,TPR_8,Trypsin_2
YHH3_k127_12284597_12	944565.HMPREF9127_0768	2.231e-11	71.0	290DM@1|root,2ZN2Z@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH3_k127_1233703_1	999630.TUZN_1129	1.973e-14	82.0	COG0467@1|root,arCOG01171@2157|Archaea,2XPNC@28889|Crenarchaeota	28889|Crenarchaeota	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
YHH3_k127_1233703_0	246969.TAM4_666	2.791e-48	182.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
YHH3_k127_1233703_2	523845.AQXV01000047_gene763	5.233e-08	59.0	COG0526@1|root,arCOG01218@2157|Archaea,2Y8A7@28890|Euryarchaeota	28890|Euryarchaeota	O	Redox-active disulfide protein 1	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
YHH3_k127_1233703_3	204536.SULAZ_1509	3.362e-07	56.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
YHH3_k127_12339230_2	1137268.AZXF01000010_gene2754	1.519e-09	62.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
YHH3_k127_12339230_1	7165.AGAP010875-PA	4.692e-33	134.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa,3CXE2@33213|Bilateria,41YZI@6656|Arthropoda,3SJKJ@50557|Insecta,44YPV@7147|Diptera,45D4S@7148|Nematocera	33208|Metazoa	U	Rab subfamily of small GTPases	RAB18	GO:0000166,GO:0001654,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0006810,GO:0006913,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034389,GO:0035556,GO:0036094,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0097159,GO:0097367,GO:0098827,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
YHH3_k127_12339230_0	1173024.KI912148_gene3126	2.038e-78	263.0	COG0753@1|root,COG0753@2|Bacteria,1FZYK@1117|Cyanobacteria,1JJT0@1189|Stigonemataceae	1117|Cyanobacteria	P	Catalase	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
YHH3_k127_12353997_2	696281.Desru_3253	6.061e-73	255.0	COG0327@1|root,COG0327@2|Bacteria,1V149@1239|Firmicutes,24D91@186801|Clostridia	186801|Clostridia	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
YHH3_k127_12353997_4	485913.Krac_5445	7.673e-49	188.0	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	2|Bacteria	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
YHH3_k127_12353997_5	96561.Dole_0769	1.122e-33	147.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2X5UF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_12353997_1	1265505.ATUG01000002_gene1143	1.969e-73	263.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42S94@68525|delta/epsilon subdivisions,2WNCW@28221|Deltaproteobacteria,2MNBQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
YHH3_k127_12353997_3	1120983.KB894572_gene3274	1.662e-63	233.0	COG2807@1|root,COG2807@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_12353997_6	56110.Oscil6304_2815	0.0008696	52.0	COG1404@1|root,COG1520@1|root,COG2931@1|root,COG4733@1|root,COG4935@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,1G342@1117|Cyanobacteria,1HH6R@1150|Oscillatoriales	1117|Cyanobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP
YHH3_k127_12353997_0	309799.DICTH_0189	3.827e-112	375.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
YHH3_k127_12366801_0	944479.JQLX01000014_gene1612	4.23e-47	181.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2M6I7@213113|Desulfurellales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
YHH3_k127_12366801_1	313624.NSP_28300	3.441e-20	96.0	COG2823@1|root,COG2823@2|Bacteria,1GBV7@1117|Cyanobacteria,1HPUI@1161|Nostocales	1117|Cyanobacteria	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
YHH3_k127_12380161_0	391623.TERMP_01316	3.803e-117	392.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242UT@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
YHH3_k127_12380161_4	1117319.PSPO_11942	3.716e-06	58.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2PZW7@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	U	COG3267 Type II secretory pathway, component ExeA	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1,T2SSB
YHH3_k127_12380161_1	224719.Abm4_0431	6.375e-51	187.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,23NYI@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
YHH3_k127_12380161_3	391623.TERMP_01563	8.372e-25	108.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,244FN@183968|Thermococci	183968|Thermococci	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
YHH3_k127_12380161_2	224325.AF_1973	2.474e-37	147.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,247I6@183980|Archaeoglobi	183980|Archaeoglobi	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
YHH3_k127_12419509_15	1365176.N186_01885	1.288e-26	116.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
YHH3_k127_12419509_26	553175.POREN0001_1260	7.906e-06	56.0	COG4886@1|root,COG4886@2|Bacteria,4P1V9@976|Bacteroidetes,2FWQA@200643|Bacteroidia,22ZM1@171551|Porphyromonadaceae	976|Bacteroidetes	S	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12419509_9	604354.TSIB_2031	1.934e-35	147.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,243PQ@183968|Thermococci	183968|Thermococci	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
YHH3_k127_12419509_3	387631.Asulf_00251	6.505e-102	346.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,2460N@183980|Archaeoglobi	183980|Archaeoglobi	J	MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
YHH3_k127_12419509_24	572478.Vdis_2001	2.252e-07	56.0	COG1977@1|root,arCOG00536@2157|Archaea,2XRHB@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
YHH3_k127_12419509_21	545697.HMPREF0216_03041	2.262e-13	76.0	2E481@1|root,32Z3Y@2|Bacteria,1VFF1@1239|Firmicutes,24SN5@186801|Clostridia,36NFZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12419509_1	1151117.AJLF01000001_gene1051	3.949e-197	627.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
YHH3_k127_12419509_2	1184251.TCELL_0804	4.04e-126	420.0	COG0403@1|root,arCOG00077@2157|Archaea,2XQ1W@28889|Crenarchaeota	28889|Crenarchaeota	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
YHH3_k127_12419509_22	1459636.NTE_02308	6.263e-13	73.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
YHH3_k127_12419509_7	384616.Pisl_1038	1.953e-56	208.0	COG3294@1|root,arCOG04230@2157|Archaea,2XQ9R@28889|Crenarchaeota	28889|Crenarchaeota	S	phosphohydrolase	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
YHH3_k127_12419509_10	930945.SiRe_1932	1.244e-34	145.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
YHH3_k127_12419509_8	1041930.Mtc_1755	1.085e-45	171.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,2N9JJ@224756|Methanomicrobia	224756|Methanomicrobia	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
YHH3_k127_12419509_6	304371.MCP_1531	1.503e-56	206.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
YHH3_k127_12419509_11	456320.Mvol_0152	3.593e-34	136.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23QZQ@183939|Methanococci	183939|Methanococci	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
YHH3_k127_12419509_14	386456.JQKN01000002_gene2879	9.025e-29	129.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,23NXE@183925|Methanobacteria	183925|Methanobacteria	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
YHH3_k127_12419509_16	373903.Hore_18270	1.143e-23	105.0	COG1342@1|root,COG1342@2|Bacteria,1V5RE@1239|Firmicutes,25CFP@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0251 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
YHH3_k127_12419509_17	1121448.DGI_1972	7.122e-21	96.0	COG1433@1|root,COG1433@2|Bacteria,1RDPR@1224|Proteobacteria,42SR6@68525|delta/epsilon subdivisions,2WPP8@28221|Deltaproteobacteria,2MBY2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
YHH3_k127_12419509_18	523850.TON_0307	3.989e-20	93.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,244B2@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
YHH3_k127_12419509_12	386456.JQKN01000002_gene2878	2.318e-33	133.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,23P0P@183925|Methanobacteria	183925|Methanobacteria	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
YHH3_k127_12419509_23	523845.AQXV01000038_gene1097	1.123e-09	68.0	COG3390@1|root,arCOG02258@2157|Archaea,2XYKW@28890|Euryarchaeota,23R24@183939|Methanococci	183939|Methanococci	S	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	tRNA_anti-codon
YHH3_k127_12419509_4	439481.Aboo_0490	9.652e-100	336.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
YHH3_k127_12419509_19	368408.Tpen_0662	1.808e-15	78.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
YHH3_k127_12419509_20	694429.Pyrfu_0112	2.765e-14	75.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
YHH3_k127_12419509_0	1365176.N186_02525	6.623e-277	870.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
YHH3_k127_12419509_25	1459636.NTE_01660	3.194e-07	55.0	arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12419509_13	693661.Arcve_0927	1.949e-31	128.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,2467U@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
YHH3_k127_12419509_5	360910.BAV0089	2.221e-71	255.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	2.3.1.157,2.3.1.79,2.7.7.23	ko:K00661,ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
YHH3_k127_12421961_1	1048983.EL17_04825	1.972e-45	173.0	COG0500@1|root,COG0500@2|Bacteria,4PPBM@976|Bacteroidetes	976|Bacteroidetes	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
YHH3_k127_12421961_3	1499967.BAYZ01000033_gene1105	1.1e-36	145.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_12421961_0	945713.IALB_0205	1.003e-74	254.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
YHH3_k127_12421961_2	368407.Memar_2430	1.536e-41	158.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	2157|Archaea	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12431460_0	1229909.NSED_09940	1.075e-41	162.0	COG0463@1|root,arCOG00894@2157|Archaea,41SAS@651137|Thaumarchaeota	651137|Thaumarchaeota	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
YHH3_k127_12436310_3	1487923.DP73_06490	4.844e-15	76.0	COG1146@1|root,COG1146@2|Bacteria,1W2AI@1239|Firmicutes,25709@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
YHH3_k127_12436310_0	1121468.AUBR01000028_gene1506	9.813e-44	171.0	COG1149@1|root,COG1149@2|Bacteria,1VDSQ@1239|Firmicutes,24NTS@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_12436310_2	224325.AF_1964	1.039e-17	87.0	COG3370@1|root,arCOG01668@2157|Archaea,2XZG9@28890|Euryarchaeota,2478V@183980|Archaeoglobi	183980|Archaeoglobi	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12436310_1	368408.Tpen_1824	1.305e-18	90.0	COG1249@1|root,arCOG01068@2157|Archaea,2XPKZ@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
YHH3_k127_12440693_4	309803.CTN_0311	1.144e-36	145.0	COG0778@1|root,COG1225@1|root,COG0778@2|Bacteria,COG1225@2|Bacteria,2GD74@200918|Thermotogae	200918|Thermotogae	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Nitroreductase
YHH3_k127_12440693_0	1121472.AQWN01000003_gene1546	2.311e-141	460.0	COG1960@1|root,COG1960@2|Bacteria,1TRR9@1239|Firmicutes,24AJB@186801|Clostridia,260H9@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
YHH3_k127_12440693_5	933801.Ahos_1041	1.14e-18	89.0	COG1146@1|root,arCOG04548@2157|Archaea	2157|Archaea	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
YHH3_k127_12440693_8	880073.Calab_1834	2.781e-09	68.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
YHH3_k127_12440693_10	679190.HMPREF0650_2184	4.329e-06	57.0	COG4886@1|root,COG4886@2|Bacteria,4P2U2@976|Bacteroidetes,2FXHV@200643|Bacteroidia	976|Bacteroidetes	C	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12440693_1	221103.XP_007854297.1	3.6e-65	233.0	COG1028@1|root,KOG0725@2759|Eukaryota,39TUM@33154|Opisthokonta,3Q54J@4751|Fungi,3VCG0@5204|Basidiomycota,22BUY@155619|Agaricomycetes,3W5MD@5338|Agaricales	4751|Fungi	Q	Nad dependent epimerase dehydratase family protein	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
YHH3_k127_12440693_6	166318.Syn8016DRAFT_1488	5.315e-18	93.0	COG0500@1|root,COG2226@2|Bacteria,1G3XX@1117|Cyanobacteria,1GYUK@1129|Synechococcus	1117|Cyanobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family	gsmt	GO:0001505,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006544,GO:0006575,GO:0006577,GO:0006578,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0009058,GO:0009069,GO:0009987,GO:0016740,GO:0016741,GO:0017144,GO:0017174,GO:0019286,GO:0019752,GO:0031455,GO:0031456,GO:0032259,GO:0034641,GO:0042133,GO:0042398,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0052730,GO:0065007,GO:0065008,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.1.1.156	ko:K18896	ko00260,map00260	-	R10060	RC00003,RC03038	ko00000,ko00001,ko01000	-	-	-	Methyltransf_25
YHH3_k127_12440693_2	871963.Desdi_1656	1.881e-61	220.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_12440693_12	679926.Mpet_1131	4.278e-05	53.0	arCOG04915@1|root,arCOG04915@2157|Archaea,2Y3CG@28890|Euryarchaeota,2NAQQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12440693_11	679926.Mpet_2434	3.701e-05	54.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
YHH3_k127_12440693_9	519442.Huta_1783	1.595e-08	64.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
YHH3_k127_12440693_13	593750.Metfor_1178	9.486e-05	53.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
YHH3_k127_12440693_14	694430.Natoc_1706	0.0002709	51.0	COG3428@1|root,arCOG04619@2157|Archaea,2XU23@28890|Euryarchaeota,23T8S@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
YHH3_k127_12440693_7	1121324.CLIT_5c01360	1.185e-16	90.0	COG1082@1|root,COG1082@2|Bacteria,1V56C@1239|Firmicutes,24D55@186801|Clostridia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
YHH3_k127_12440693_3	536232.CLM_3282	4.64e-54	194.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
YHH3_k127_12441814_0	926550.CLDAP_25010	4.189e-275	860.0	COG0365@1|root,COG0365@2|Bacteria,2G830@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
YHH3_k127_12441814_1	926560.KE387025_gene4131	8.414e-72	252.0	COG1028@1|root,COG1028@2|Bacteria,1WM2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
YHH3_k127_12441814_3	272558.10174430	1.013e-17	93.0	COG4552@1|root,COG4552@2|Bacteria,1TRPM@1239|Firmicutes,4HD22@91061|Bacilli,1ZB8R@1386|Bacillus	91061|Bacilli	S	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
YHH3_k127_12454737_1	688269.Theth_1319	6.437e-78	269.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
YHH3_k127_12454737_2	751944.HALDL1_09015	5.315e-15	87.0	COG4552@1|root,arCOG10664@2157|Archaea,2XTW3@28890|Euryarchaeota,23S97@183963|Halobacteria	183963|Halobacteria	S	acetyltransferase involved in intracellular survival and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
YHH3_k127_12454737_0	243231.GSU1873	8.715e-93	327.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,43S56@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
YHH3_k127_12490069_3	1104324.P186_0629	8.661e-05	46.0	COG1522@1|root,arCOG01117@2157|Archaea,2XQQ4@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
YHH3_k127_12490069_2	926550.CLDAP_35280	8.852e-36	147.0	COG0454@1|root,COG0456@2|Bacteria,2G91C@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_12490069_0	515635.Dtur_1196	5.75e-71	250.0	COG1085@1|root,COG1085@2|Bacteria	2|Bacteria	C	galactose-1-phosphate uridylyltransferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
YHH3_k127_12490069_1	656519.Halsa_0118	7.217e-61	225.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,3WADG@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
YHH3_k127_12521591_0	118161.KB235922_gene3489	4.601e-142	461.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100,Hydrolase_4,Peptidase_S9
YHH3_k127_12521591_1	1033734.CAET01000048_gene1699	1.079e-18	98.0	COG1670@1|root,COG1670@2|Bacteria,1UZR2@1239|Firmicutes,4HC5N@91061|Bacilli,1ZGB1@1386|Bacillus	91061|Bacilli	J	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
YHH3_k127_12521967_0	309798.COPRO5265_0199	3.175e-117	391.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,42EZN@68295|Thermoanaerobacterales	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
YHH3_k127_12534189_1	1223545.GS4_11_01520	6.425e-36	148.0	COG0714@1|root,COG0714@2|Bacteria,2GMBP@201174|Actinobacteria,4GCX8@85026|Gordoniaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,VWA_CoxE
YHH3_k127_12534189_0	1123013.AUIC01000002_gene1053	5.198e-38	151.0	COG2515@1|root,COG2515@2|Bacteria,2GIV5@201174|Actinobacteria,4FPXJ@85023|Microbacteriaceae	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
YHH3_k127_12559821_2	1105110.MC5_04450	1.025e-08	65.0	COG4285@1|root,COG4285@2|Bacteria,1RE6P@1224|Proteobacteria	1224|Proteobacteria	S	Biotin-protein ligase, N terminal	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
YHH3_k127_12559821_3	224325.AF_1264	3.084e-06	59.0	COG0640@1|root,arCOG00734@2157|Archaea,2XXHJ@28890|Euryarchaeota	28890|Euryarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
YHH3_k127_12559821_0	316274.Haur_3627	9.03e-143	473.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi,37630@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_12559821_1	479434.Sthe_1188	1.286e-118	404.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi,27Z0B@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_1256964_3	1123376.AUIU01000015_gene444	3.138e-22	98.0	2E32K@1|root,32Y2U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1256964_5	351160.LRC332	5.571e-18	93.0	arCOG01190@1|root,arCOG01190@2157|Archaea	351160.LRC332|-	G	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1256964_2	401526.TcarDRAFT_2312	1.587e-37	156.0	COG1409@1|root,COG1409@2|Bacteria,1VDYM@1239|Firmicutes	1239|Firmicutes	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
YHH3_k127_1256964_1	351160.LRC325	7.352e-54	203.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	ABC_cobalt,Oxidored_molyb
YHH3_k127_1256964_0	1089553.Tph_c04360	1.79e-96	332.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,42EZ2@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
YHH3_k127_1256964_4	1294265.JCM21738_3748	7.097e-19	96.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,4H9VT@91061|Bacilli,1ZBNS@1386|Bacillus	91061|Bacilli	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
YHH3_k127_1256964_6	1158294.JOMI01000002_gene2822	2.063e-06	58.0	COG0454@1|root,COG0456@2|Bacteria,4NU4N@976|Bacteroidetes,2G2BS@200643|Bacteroidia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_12592514_0	1121422.AUMW01000011_gene93	1.687e-85	295.0	COG2070@1|root,COG2070@2|Bacteria,1VTQJ@1239|Firmicutes,24ZN0@186801|Clostridia,26495@186807|Peptococcaceae	186801|Clostridia	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
YHH3_k127_12592514_1	273116.14324612	1.101e-35	140.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota	28890|Euryarchaeota	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
YHH3_k127_12603531_0	357808.RoseRS_1136	1.061e-50	189.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi,376SH@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM F420-dependent oxidoreductase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
YHH3_k127_12637086_0	443254.Marpi_0537	2.03e-70	256.0	COG1164@1|root,COG1164@2|Bacteria,2GCJ4@200918|Thermotogae	200918|Thermotogae	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
YHH3_k127_12637086_1	243232.MJ_0180	9.271e-39	149.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,23QTT@183939|Methanococci	183939|Methanococci	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
YHH3_k127_12637086_2	443144.GM21_2423	0.000488	48.0	COG0457@1|root,COG0457@2|Bacteria	443144.GM21_2423|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1265247_3	1220534.B655_0474	8.578e-13	75.0	arCOG07448@1|root,arCOG07448@2157|Archaea,2XXRD@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1265247_0	604354.TSIB_1748	1.058e-195	625.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,242UA@183968|Thermococci	183968|Thermococci	O	Belongs to the TCP-1 chaperonin family	ths	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
YHH3_k127_1265247_2	591019.Shell_1086	6.8e-25	115.0	COG4028@1|root,arCOG04328@2157|Archaea,2XQGW@28889|Crenarchaeota	28889|Crenarchaeota	S	P-loop ATPase GTPase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1265247_1	589924.Ferp_2549	3.686e-86	295.0	COG0492@1|root,arCOG01296@2157|Archaea,2XTJW@28890|Euryarchaeota,24639@183980|Archaeoglobi	183980|Archaeoglobi	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
YHH3_k127_1265247_4	3711.Bra005031.1-P	1.515e-05	57.0	COG5029@1|root,KOG0367@2759|Eukaryota,37MPB@33090|Viridiplantae,3G8D1@35493|Streptophyta,3HNU1@3699|Brassicales	35493|Streptophyta	O	Prenyltransferase and squalene oxidase repeat	-	GO:0001101,GO:0003674,GO:0003824,GO:0004659,GO:0004661,GO:0004662,GO:0004663,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005953,GO:0005968,GO:0006464,GO:0006807,GO:0006950,GO:0007275,GO:0008150,GO:0008152,GO:0008270,GO:0008284,GO:0008318,GO:0009414,GO:0009415,GO:0009555,GO:0009628,GO:0009719,GO:0009725,GO:0009733,GO:0009737,GO:0009787,GO:0009788,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010035,GO:0010556,GO:0010558,GO:0010605,GO:0010646,GO:0010648,GO:0016740,GO:0016765,GO:0018342,GO:0018344,GO:0019222,GO:0019538,GO:0022622,GO:0023051,GO:0023057,GO:0032501,GO:0032502,GO:0032991,GO:0033993,GO:0034097,GO:0036211,GO:0042127,GO:0042221,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045787,GO:0046872,GO:0046914,GO:0048229,GO:0048364,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051726,GO:0051769,GO:0051771,GO:0060255,GO:0065007,GO:0071704,GO:0097305,GO:0097354,GO:0099402,GO:0140096,GO:1901419,GO:1901420,GO:1901564,GO:1901700,GO:1902494,GO:1905957,GO:1905958,GO:1990234	2.5.1.59	ko:K11713	-	-	-	-	ko00000,ko01000,ko01006	-	-	-	Prenyltrans
YHH3_k127_12696501_3	178306.PAE3418	1.563e-06	54.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
YHH3_k127_12696501_1	529709.PYCH_12090	4.698e-58	214.0	COG1063@1|root,arCOG01459@2157|Archaea,2Y683@28890|Euryarchaeota,2450G@183968|Thermococci	183968|Thermococci	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_12696501_0	593117.TGAM_0434	9.819e-93	321.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,243BB@183968|Thermococci	183968|Thermococci	S	PFAM PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
YHH3_k127_12696501_2	453591.Igni_0828	3.314e-21	96.0	COG3357@1|root,arCOG04479@2157|Archaea,2XR5D@28889|Crenarchaeota	28889|Crenarchaeota	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_12697925_0	589924.Ferp_0782	1.629e-78	283.0	COG3276@1|root,arCOG01562@2157|Archaea,2XTHU@28890|Euryarchaeota,246PY@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM Protein synthesis factor, GTP-binding	-	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	AlbA_2,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
YHH3_k127_12700703_0	1006006.Mcup_0591	1.306e-05	51.0	COG0013@1|root,arCOG01255@2157|Archaea,2XPZK@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
YHH3_k127_1273915_1	946235.CAER01000002_gene718	3.856e-21	103.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4HA3R@91061|Bacilli,23IKE@182709|Oceanobacillus	91061|Bacilli	G	Haloacid dehalogenase-like hydrolase	nagD	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
YHH3_k127_1273915_0	186497.PF0056	5.705e-23	103.0	COG1917@1|root,arCOG02994@2157|Archaea,2XZAN@28890|Euryarchaeota,2446X@183968|Thermococci	183968|Thermococci	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
YHH3_k127_12739544_2	1163730.FFONT_0377	2.079e-20	98.0	COG0681@1|root,arCOG01739@2157|Archaea,2XQV6@28889|Crenarchaeota	28889|Crenarchaeota	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
YHH3_k127_12739544_3	927677.ALVU02000001_gene3865	3.425e-11	76.0	COG1485@1|root,COG1485@2|Bacteria	2|Bacteria	S	mitochondrial protein catabolic process	-	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
YHH3_k127_12739544_4	694431.DESACE_06605	4.9e-08	60.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
YHH3_k127_12739544_5	5334.XP_003026113.1	0.0007651	51.0	KOG2615@1|root,KOG2615@2759|Eukaryota,38FGP@33154|Opisthokonta,3NVFU@4751|Fungi,3UYPA@5204|Basidiomycota,22BTP@155619|Agaricomycetes,3W5V3@5338|Agaricales	4751|Fungi	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_12739544_1	243274.THEMA_09505	7.163e-27	117.0	COG1670@1|root,COG1670@2|Bacteria,2GCW5@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
YHH3_k127_12739544_0	868131.MSWAN_0193	5.967e-32	132.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
YHH3_k127_12749760_0	374847.Kcr_0159	6.971e-91	314.0	COG0665@1|root,arCOG00755@2157|Archaea	2157|Archaea	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO
YHH3_k127_12749760_1	1349822.NSB1T_01655	6.644e-31	134.0	COG0598@1|root,COG0598@2|Bacteria,4NGM7@976|Bacteroidetes,2FNKU@200643|Bacteroidia,22WPX@171551|Porphyromonadaceae	976|Bacteroidetes	P	Transporter	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
YHH3_k127_12766831_5	888056.HMPREF9062_0781	1.893e-07	62.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4D40A@85005|Actinomycetales	201174|Actinobacteria	Q	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_12766831_7	6500.XP_005103777.1	8.181e-05	53.0	KOG3780@1|root,KOG3780@2759|Eukaryota	2759|Eukaryota	E	ubiquitin-dependent endocytosis	-	GO:0001932,GO:0002029,GO:0002031,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006897,GO:0006898,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008277,GO:0009267,GO:0009605,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010646,GO:0010648,GO:0016020,GO:0016192,GO:0019220,GO:0019222,GO:0019899,GO:0019902,GO:0019903,GO:0022401,GO:0023051,GO:0023057,GO:0023058,GO:0030346,GO:0030587,GO:0031152,GO:0031323,GO:0031399,GO:0031623,GO:0031667,GO:0031668,GO:0031669,GO:0032268,GO:0032502,GO:0033554,GO:0042325,GO:0042594,GO:0043112,GO:0043170,GO:0043405,GO:0043408,GO:0043549,GO:0043949,GO:0044237,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0045744,GO:0045859,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048856,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051338,GO:0051703,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071900,GO:0071944,GO:0080090,GO:0090702,GO:0098630,GO:0098657,GO:0098743,GO:0099120,GO:1902531	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N,C2
YHH3_k127_12766831_0	439481.Aboo_0846	7.719e-127	419.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,3F37W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	class II (D K and N)	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
YHH3_k127_12766831_6	1541960.KQ78_00382	9.218e-06	59.0	COG3291@1|root,COG3291@2|Bacteria,3WUQ7@544448|Tenericutes	544448|Tenericutes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_12766831_3	574087.Acear_1982	2.545e-26	113.0	COG0840@1|root,COG2703@1|root,COG0840@2|Bacteria,COG2703@2|Bacteria,1VAI0@1239|Firmicutes,24MQU@186801|Clostridia	186801|Clostridia	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin,MCPsignal
YHH3_k127_12766831_2	1120973.AQXL01000116_gene322	4.457e-35	146.0	COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,4HEHP@91061|Bacilli,2797U@186823|Alicyclobacillaceae	91061|Bacilli	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
YHH3_k127_12766831_4	313594.PI23P_09120	1.303e-14	83.0	COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,1HZ1M@117743|Flavobacteriia,3VV76@52959|Polaribacter	976|Bacteroidetes	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ,PDZ_2
YHH3_k127_12766831_1	1047013.AQSP01000109_gene2441	9.325e-69	242.0	COG0500@1|root,COG2226@2|Bacteria,2NP8K@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
YHH3_k127_12779817_0	931277.C448_09802	6.653e-09	67.0	COG0464@1|root,arCOG01308@2157|Archaea,2XVSZ@28890|Euryarchaeota,23RZB@183963|Halobacteria	183963|Halobacteria	O	COG0464 ATPases of the AAA class	ruvB	-	-	-	-	-	-	-	-	-	-	-	AAA
YHH3_k127_12813492_1	203122.Sde_2049	2.991e-16	91.0	COG5184@1|root,COG5276@1|root,COG5644@1|root,COG5184@2|Bacteria,COG5276@2|Bacteria,COG5644@2|Bacteria,1QX03@1224|Proteobacteria,1T31Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1_2
YHH3_k127_12813492_0	546269.HMPREF0389_01538	2.029e-17	93.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,25QYQ@186804|Peptostreptococcaceae	186801|Clostridia	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
YHH3_k127_12850237_0	319795.Dgeo_1890	4.823e-222	703.0	COG0556@1|root,COG0556@2|Bacteria,1WJ4X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
YHH3_k127_12850237_1	521460.Athe_1437	1.288e-115	382.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
YHH3_k127_12867064_0	1150474.JQJI01000005_gene277	1.977e-72	259.0	COG1251@1|root,COG1251@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	1.7.1.15	ko:K00362,ko:K02192	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2
YHH3_k127_12867064_4	933801.Ahos_2292	1.416e-09	70.0	COG0419@1|root,arCOG00368@2157|Archaea,2XQHC@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_23,Rad50_zn_hook,SMC_N,SbcCD_C
YHH3_k127_12867064_1	644281.MFS40622_0387	7.119e-20	103.0	COG0419@1|root,arCOG00385@1|root,arCOG05422@1|root,arCOG00368@2157|Archaea,arCOG00385@2157|Archaea,arCOG05422@2157|Archaea,2XTC7@28890|Euryarchaeota,23Q3I@183939|Methanococci	183939|Methanococci	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook
YHH3_k127_12867064_2	1006006.Mcup_1241	1.778e-18	98.0	COG0420@1|root,arCOG00397@2157|Archaea,2XQWG@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
YHH3_k127_12867064_5	293826.Amet_4279	3.685e-08	64.0	COG1266@1|root,COG1266@2|Bacteria,1V1I8@1239|Firmicutes,24EXX@186801|Clostridia,36IEW@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
YHH3_k127_12867064_3	118173.KB235914_gene4250	8.045e-14	80.0	COG0189@1|root,COG0189@2|Bacteria,1GQF5@1117|Cyanobacteria	1117|Cyanobacteria	HJ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
YHH3_k127_12868214_0	1304284.L21TH_0262	2.297e-43	167.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,36F9I@31979|Clostridiaceae	186801|Clostridia	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
YHH3_k127_12868214_1	1123252.ATZF01000013_gene2766	3.683e-37	150.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4HBE6@91061|Bacilli,27BEA@186824|Thermoactinomycetaceae	91061|Bacilli	S	Alpha/beta hydrolase family	est	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
YHH3_k127_1306377_0	1121904.ARBP01000010_gene2365	0.0007402	52.0	COG0457@1|root,COG3920@1|root,COG0457@2|Bacteria,COG3920@2|Bacteria,4NIA6@976|Bacteroidetes,47VEN@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,TPR_12
YHH3_k127_1311171_0	7668.SPU_016872-tr	0.0	1015.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
YHH3_k127_1311505_7	1347087.CBYO010000020_gene2849	3.347e-09	62.0	COG3255@1|root,COG3255@2|Bacteria,1VFEY@1239|Firmicutes,4HNS7@91061|Bacilli	91061|Bacilli	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
YHH3_k127_1311505_0	1163730.FFONT_0226	1.663e-141	469.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_1311505_4	1163730.FFONT_0548	1.212e-47	179.0	COG0235@1|root,arCOG04226@2157|Archaea,2XQGF@28889|Crenarchaeota	28889|Crenarchaeota	G	Class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
YHH3_k127_1311505_2	557599.MKAN_03715	1.635e-64	239.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
YHH3_k127_1311505_1	572546.Arcpr_0691	2.406e-67	241.0	COG0111@1|root,COG0440@1|root,arCOG01754@2157|Archaea,arCOG04445@2157|Archaea,2XU9V@28890|Euryarchaeota,246MG@183980|Archaeoglobi	183980|Archaeoglobi	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
YHH3_k127_1311505_3	1121472.AQWN01000010_gene532	1.413e-61	220.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,2611J@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
YHH3_k127_1311505_5	1220534.B655_2435	4.743e-26	121.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
YHH3_k127_1311505_6	1197130.BAFM01000009_gene1757	6.155e-12	70.0	COG1846@1|root,arCOG00732@2157|Archaea,2XZ9E@28890|Euryarchaeota,23X3E@183963|Halobacteria	183963|Halobacteria	K	COG1846 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
YHH3_k127_1311505_8	439481.Aboo_1200	2.209e-08	60.0	COG3255@1|root,arCOG01843@2157|Archaea,2Y75B@28890|Euryarchaeota,3F3F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
YHH3_k127_1322345_0	573413.Spirs_1723	2.236e-18	92.0	COG1829@1|root,COG1829@2|Bacteria	2|Bacteria	S	kinase activity	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
YHH3_k127_1332682_0	1163730.FFONT_0454	3.706e-43	170.0	COG0142@1|root,arCOG01726@2157|Archaea,2XPZM@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the FPP GGPP synthase family	fgs	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
YHH3_k127_1349959_0	1121090.KB894722_gene3207	4.62e-81	279.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,4HBB2@91061|Bacilli,1ZCHI@1386|Bacillus	91061|Bacilli	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	GO:0003674,GO:0003824,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	iYO844.BSU14520	Adenine_deam_C,Amidohydro_1
YHH3_k127_1349959_1	493475.GARC_0328	1.289e-29	126.0	COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1349959_2	314285.KT71_13065	1.034e-27	114.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1J9ZG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	acdS	-	3.5.99.7	ko:K01505	ko00270,map00270	-	R00997	RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
YHH3_k127_1358687_1	1122915.AUGY01000010_gene4598	6.098e-31	124.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,4HASG@91061|Bacilli,26UEI@186822|Paenibacillaceae	91061|Bacilli	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
YHH3_k127_1358687_0	264732.Moth_0154	2.175e-41	156.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42HVK@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_1361322_0	1365176.N186_04735	1.154e-149	485.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPXJ@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
YHH3_k127_1388996_0	247490.KSU1_C0203	1.071e-89	308.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
YHH3_k127_1388996_1	1121899.Q764_10105	0.0004605	44.0	COG1670@1|root,COG1670@2|Bacteria,4NUC3@976|Bacteroidetes,1I4ZE@117743|Flavobacteriia,2NW48@237|Flavobacterium	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
YHH3_k127_139218_1	144197.XP_008298306.1	1.745e-05	50.0	KOG0445@1|root,KOG0445@2759|Eukaryota,38D8G@33154|Opisthokonta,3BCUN@33208|Metazoa,3CV9H@33213|Bilateria,48AT1@7711|Chordata,493BF@7742|Vertebrata,49TXX@7898|Actinopterygii	33208|Metazoa	Z	Supervillin-like	-	GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0008092	-	ko:K10369	-	-	-	-	ko00000,ko04812	-	-	-	Gelsolin,VHP
YHH3_k127_139218_0	1123290.AUDQ01000001_gene2972	1.537e-50	188.0	COG1834@1|root,COG1834@2|Bacteria,1TRPV@1239|Firmicutes,4H9YU@91061|Bacilli,26EA9@186818|Planococcaceae	91061|Bacilli	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
YHH3_k127_139218_2	439235.Dalk_1040	8.145e-05	53.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	quiC	-	4.2.1.118	ko:K09483	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R01627	RC00568	ko00000,ko00001,ko01000	-	-	-	Beta_helix,CHU_C,NosD
YHH3_k127_140543_1	195522.BD01_0696	4.046e-08	63.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,242Z4@183968|Thermococci	183968|Thermococci	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
YHH3_k127_140543_0	384616.Pisl_0028	7.52e-11	68.0	COG1840@1|root,arCOG00221@2157|Archaea,2XPPY@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM extracellular solute-binding protein family 1	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
YHH3_k127_1410497_1	246194.CHY_0809	1.135e-18	92.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia,42GRM@68295|Thermoanaerobacterales	186801|Clostridia	H	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K13531	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
YHH3_k127_1410497_3	416348.Hlac_3222	0.0005363	51.0	COG3291@1|root,arCOG03396@2157|Archaea	2157|Archaea	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	A2M_comp,CARDB,Prenyltrans,SQHop_cyclase_C,Thiol-ester_cl
YHH3_k127_1410497_2	1343739.PAP_03275	1.481e-09	62.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
YHH3_k127_1410497_0	635013.TherJR_2600	2.442e-84	296.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
YHH3_k127_1422009_3	373903.Hore_04870	5.194e-37	150.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,3WAJM@53433|Halanaerobiales	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
YHH3_k127_1422009_0	1499967.BAYZ01000026_gene1636	1.356e-86	294.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
YHH3_k127_1422009_1	374847.Kcr_1556	1.033e-61	228.0	COG0624@1|root,arCOG01107@2157|Archaea	2157|Archaea	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
YHH3_k127_1422009_2	710696.Intca_3130	1.028e-52	190.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FJQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
YHH3_k127_1437119_12	1348657.M622_07890	0.000772	53.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,2KVRD@206389|Rhodocyclales	206389|Rhodocyclales	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_1437119_9	1116369.KB890024_gene2838	2.394e-12	81.0	COG0577@1|root,COG0577@2|Bacteria,1PRGU@1224|Proteobacteria,2U2BA@28211|Alphaproteobacteria,43NWZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_1437119_6	1410632.JHWW01000001_gene1077	2.63e-48	186.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,27KAQ@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_1437119_11	1151117.AJLF01000001_gene778	0.0003206	49.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,2448C@183968|Thermococci	183968|Thermococci	L	UPF0292 protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
YHH3_k127_1437119_4	411490.ANACAC_02754	4.855e-96	326.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_1437119_10	1463900.JOIX01000127_gene3649	7.86e-08	59.0	COG1764@1|root,COG1764@2|Bacteria,2IID0@201174|Actinobacteria	201174|Actinobacteria	O	organic hydroperoxide resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
YHH3_k127_1437119_7	415426.Hbut_1150	7.97e-29	122.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
YHH3_k127_1437119_5	997346.HMPREF9374_1164	6.901e-58	211.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,4HB6B@91061|Bacilli,27B49@186824|Thermoactinomycetaceae	91061|Bacilli	S	metal-dependent phosphoesterases (PHP family)	php	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
YHH3_k127_1437119_8	999630.TUZN_0678	9.61e-27	114.0	COG0727@1|root,arCOG02579@2157|Archaea,2XR8B@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
YHH3_k127_1437119_0	523845.AQXV01000023_gene1467	2.406e-192	617.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,23Q3J@183939|Methanococci	183939|Methanococci	E	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
YHH3_k127_1437119_3	391623.TERMP_00251	4.645e-104	344.0	COG2820@1|root,arCOG01324@2157|Archaea,2XSWN@28890|Euryarchaeota,243RY@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
YHH3_k127_1437119_2	1051632.TPY_1071	2.243e-107	355.0	COG1830@1|root,COG1830@2|Bacteria,1TR4S@1239|Firmicutes,24CYU@186801|Clostridia	186801|Clostridia	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
YHH3_k127_1437119_1	572546.Arcpr_1256	1.998e-154	496.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,245YC@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
YHH3_k127_1451314_0	4513.MLOC_75997.1	4.462e-79	270.0	COG1697@1|root,KOG2795@2759|Eukaryota,37QGK@33090|Viridiplantae,3G85Y@35493|Streptophyta,3KVMF@4447|Liliopsida,3I71X@38820|Poales	35493|Streptophyta	L	Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity	TOP6A	GO:0000003,GO:0000228,GO:0000280,GO:0000706,GO:0000729,GO:0001708,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0008544,GO:0009888,GO:0009913,GO:0009957,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0022402,GO:0022414,GO:0030154,GO:0030855,GO:0031974,GO:0031981,GO:0032502,GO:0033554,GO:0034641,GO:0035825,GO:0042138,GO:0042623,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045165,GO:0046483,GO:0048285,GO:0048856,GO:0048869,GO:0050896,GO:0051321,GO:0051716,GO:0060429,GO:0061505,GO:0061982,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046	-	ko:K10878	ko04113,map04113	-	-	-	ko00000,ko00001,ko03400	-	-	-	TP6A_N
YHH3_k127_1451314_1	1007103.AFHW01000135_gene6421	7.13e-46	178.0	COG2159@1|root,COG2159@2|Bacteria,1TT5D@1239|Firmicutes,4HAHP@91061|Bacilli,26V85@186822|Paenibacillaceae	91061|Bacilli	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
YHH3_k127_1451314_3	868131.MSWAN_0059	5.969e-15	83.0	COG0671@1|root,arCOG07501@2157|Archaea,2XYXG@28890|Euryarchaeota,23PN8@183925|Methanobacteria	183925|Methanobacteria	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1451314_2	693661.Arcve_0172	5.615e-27	114.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2463P@183980|Archaeoglobi	183980|Archaeoglobi	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
YHH3_k127_1455674_8	6326.BUX.s01144.297	5.864e-78	292.0	COG1287@1|root,KOG2292@2759|Eukaryota,38D8E@33154|Opisthokonta,3BGVU@33208|Metazoa,3CSAS@33213|Bilateria,40ANW@6231|Nematoda,1KTS0@119089|Chromadorea	33208|Metazoa	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
YHH3_k127_1455674_15	1128421.JAGA01000002_gene783	1.957e-37	145.0	COG0509@1|root,COG0509@2|Bacteria,2NPMR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iE2348C_1286.E2348C_3156,iNJ661.Rv1826,iPC815.YPO0906	GCV_H
YHH3_k127_1455674_6	1034347.CAHJ01000038_gene4244	7.903e-87	300.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,1ZAS5@1386|Bacillus	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
YHH3_k127_1455674_12	1343739.PAP_08090	7.573e-56	207.0	COG0294@1|root,arCOG02817@2157|Archaea,2XTGI@28890|Euryarchaeota,24355@183968|Thermococci	183968|Thermococci	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
YHH3_k127_1455674_13	391623.TERMP_01266	1.954e-50	187.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,24344@183968|Thermococci	183968|Thermococci	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
YHH3_k127_1455674_2	391623.TERMP_00652	9.462e-158	522.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
YHH3_k127_1455674_3	1151117.AJLF01000001_gene1311	1.002e-121	414.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
YHH3_k127_1455674_21	662479.C440_03543	3.888e-11	74.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,23SVJ@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1455674_18	877455.Metbo_0588	8.838e-27	118.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23NZU@183925|Methanobacteria	183925|Methanobacteria	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
YHH3_k127_1455674_14	69014.TK2119	1.049e-41	159.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,243AW@183968|Thermococci	183968|Thermococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
YHH3_k127_1455674_11	868131.MSWAN_0409	8.527e-57	209.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,23NXA@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
YHH3_k127_1455674_0	224325.AF_1722	3.227e-304	970.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
YHH3_k127_1455674_10	523845.AQXV01000049_gene951	2.07e-72	271.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
YHH3_k127_1455674_4	1236689.MMALV_07230	4.439e-102	346.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota	2157|Archaea	E	Cysteine desulfurase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
YHH3_k127_1455674_20	397948.Cmaq_0929	2.195e-14	77.0	COG4888@1|root,arCOG04136@2157|Archaea	2157|Archaea	S	PFAM Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
YHH3_k127_1455674_23	673860.AciM339_0016	2.869e-07	55.0	arCOG05717@1|root,arCOG05717@2157|Archaea,2Y77I@28890|Euryarchaeota,3F3IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1455674_1	1041930.Mtc_0655	1.725e-183	607.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
YHH3_k127_1455674_16	195522.BD01_2037	5.67e-35	141.0	COG0218@1|root,arCOG00355@2157|Archaea,2XTV8@28890|Euryarchaeota,243FK@183968|Thermococci	183968|Thermococci	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
YHH3_k127_1455674_24	1121382.JQKG01000017_gene1798	0.0002086	53.0	COG4085@1|root,COG4085@2|Bacteria	2|Bacteria	S	PFAM nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,Big_2
YHH3_k127_1455674_25	296587.XP_002503713.1	0.0004482	48.0	2AM4V@1|root,2RZB5@2759|Eukaryota,37U4I@33090|Viridiplantae,34ISB@3041|Chlorophyta	3041|Chlorophyta	S	Zinc finger SWIM domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
YHH3_k127_1455674_17	1041930.Mtc_1658	4.243e-33	139.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
YHH3_k127_1455674_19	933801.Ahos_0811	4.797e-24	107.0	COG4080@1|root,arCOG01019@2157|Archaea,2XRAB@28889|Crenarchaeota	28889|Crenarchaeota	L	RecB-family nuclease (DUF2122)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2122
YHH3_k127_1455674_9	1365176.N186_03105	3.866e-76	266.0	COG0270@1|root,arCOG04157@2157|Archaea,2XPTC@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
YHH3_k127_1455674_5	35128.Thaps2376	2.297e-91	310.0	COG1577@1|root,KOG1511@2759|Eukaryota,2XDVQ@2836|Bacillariophyta	2836|Bacillariophyta	I	GHMP kinases C terminal	-	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
YHH3_k127_1455674_7	523850.TON_0392	1.292e-81	286.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
YHH3_k127_1476071_0	644282.Deba_0138	4.996e-73	251.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
YHH3_k127_1485421_0	10224.XP_002734973.1	4.472e-08	63.0	28N5S@1|root,2QUR0@2759|Eukaryota,38D3V@33154|Opisthokonta,3CNNF@33208|Metazoa	33208|Metazoa	T	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
YHH3_k127_152212_4	877455.Metbo_0105	9.014e-92	313.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23NR8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
YHH3_k127_152212_14	69014.TK1248	9.512e-36	139.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2445F@183968|Thermococci	183968|Thermococci	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
YHH3_k127_152212_5	415426.Hbut_0535	2.46e-73	253.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
YHH3_k127_152212_22	1183377.Py04_1524	3.934e-23	102.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
YHH3_k127_152212_10	224719.Abm4_1237	2.187e-44	165.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
YHH3_k127_152212_19	391623.TERMP_00133	1.268e-28	120.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
YHH3_k127_152212_18	529709.PYCH_02530	2.769e-30	124.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2444E@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
YHH3_k127_152212_6	1041930.Mtc_1534	3.261e-69	244.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
YHH3_k127_152212_26	8090.ENSORLP00000023124	8.292e-12	73.0	COG1100@1|root,KOG0070@2759|Eukaryota,38D1T@33154|Opisthokonta,3BN8W@33208|Metazoa,3CWE4@33213|Bilateria,486JF@7711|Chordata,495RS@7742|Vertebrata,4A2ST@7898|Actinopterygii	33208|Metazoa	U	Belongs to the small GTPase superfamily. Arf family	ARL11	GO:0002244,GO:0002376,GO:0002520,GO:0007275,GO:0008150,GO:0009987,GO:0030097,GO:0030154,GO:0032501,GO:0032502,GO:0048513,GO:0048534,GO:0048731,GO:0048856,GO:0048869	-	ko:K07959	-	-	-	-	ko00000,ko04031	-	-	-	Arf
YHH3_k127_152212_11	693661.Arcve_0518	8.824e-42	167.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,24609@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
YHH3_k127_152212_13	69014.TK1311	1.977e-39	149.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
YHH3_k127_152212_20	453591.Igni_0723	7.625e-26	108.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
YHH3_k127_152212_25	273075.Ta1114	9.395e-15	75.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,241X3@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
YHH3_k127_152212_17	864702.OsccyDRAFT_4233	1.218e-32	135.0	COG0105@1|root,COG0105@2|Bacteria,1G4ZN@1117|Cyanobacteria,1HAIY@1150|Oscillatoriales	1117|Cyanobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
YHH3_k127_152212_1	453591.Igni_0001	6.077e-190	610.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
YHH3_k127_152212_24	1162668.LFE_0393	2.817e-15	88.0	COG4447@1|root,COG4447@2|Bacteria,3J16A@40117|Nitrospirae	40117|Nitrospirae	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
YHH3_k127_152212_28	1380391.JIAS01000015_gene31	3.146e-05	52.0	COG0457@1|root,COG0457@2|Bacteria,1QZ3F@1224|Proteobacteria,2TY48@28211|Alphaproteobacteria,2JQQM@204441|Rhodospirillales	204441|Rhodospirillales	Q	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
YHH3_k127_152212_2	415426.Hbut_1581	7.421e-174	555.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
YHH3_k127_152212_9	1540257.JQMW01000009_gene3474	7.619e-49	179.0	COG0454@1|root,COG0456@2|Bacteria,1VCRG@1239|Firmicutes,24HS4@186801|Clostridia,36JB9@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_152212_15	1445613.JALM01000020_gene4791	5.673e-35	147.0	COG3608@1|root,COG3608@2|Bacteria,2IC8T@201174|Actinobacteria,4EAUN@85010|Pseudonocardiales	201174|Actinobacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
YHH3_k127_152212_12	868131.MSWAN_0249	6.458e-41	157.0	COG4635@1|root,arCOG00524@2157|Archaea	2157|Archaea	CH	flavodoxin	hemG	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
YHH3_k127_152212_21	373903.Hore_10380	5.311e-25	116.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia	186801|Clostridia	EG	metabolite transporter	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH3_k127_152212_7	368408.Tpen_0268	6.97e-60	213.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
YHH3_k127_152212_8	1343739.PAP_02735	1.455e-57	204.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,243D7@183968|Thermococci	183968|Thermococci	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
YHH3_k127_152212_16	384616.Pisl_0699	3.913e-34	136.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
YHH3_k127_152212_23	985053.VMUT_2061	4.063e-19	91.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
YHH3_k127_152212_3	453591.Igni_0244	8.781e-117	390.0	COG0086@1|root,arCOG04256@2157|Archaea,2XPSD@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
YHH3_k127_152212_0	1184251.TCELL_0518	0.0	1017.0	COG0086@1|root,arCOG04257@2157|Archaea,2XPT5@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
YHH3_k127_152212_27	877455.Metbo_2396	1.381e-10	62.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,23NRZ@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
YHH3_k127_1532734_1	224325.AF_0575	1.082e-18	96.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2467X@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_1532734_0	386456.JQKN01000001_gene1797	3.023e-36	151.0	COG1365@1|root,arCOG00045@2157|Archaea,2XVQG@28890|Euryarchaeota,23NNR@183925|Methanobacteria	183925|Methanobacteria	S	PFAM ExsB family protein	-	-	-	ko:K07134	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_1540933_6	485915.Dret_1031	0.0004742	44.0	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria,2M99N@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_7,Fer4_8,LUD_dom
YHH3_k127_1540933_0	1499967.BAYZ01000050_gene2833	1.035e-102	351.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	2.5.1.26	ko:K00803,ko:K11472	ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146	-	R00475,R04311	RC00020,RC00042,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_1540933_2	1054217.TALC_01537	4.272e-69	248.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,242ID@183967|Thermoplasmata	28890|Euryarchaeota	C	4Fe-4S dicluster domain	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
YHH3_k127_1540933_1	997296.PB1_08792	3.525e-72	257.0	COG2516@1|root,COG2516@2|Bacteria,1UI8Q@1239|Firmicutes,4HV1D@91061|Bacilli,1ZJTY@1386|Bacillus	91061|Bacilli	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
YHH3_k127_1540933_5	1313172.YM304_08950	5.482e-07	58.0	COG0454@1|root,COG0456@2|Bacteria,2HGCA@201174|Actinobacteria,4CNAC@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
YHH3_k127_1540933_3	234267.Acid_2077	9.977e-53	206.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
YHH3_k127_1540933_4	572546.Arcpr_0344	8.855e-48	188.0	COG0144@1|root,arCOG00974@2157|Archaea,2XSWG@28890|Euryarchaeota,245SS@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
YHH3_k127_155317_0	1121468.AUBR01000005_gene102	6.548e-14	75.0	COG2267@1|root,COG2267@2|Bacteria,1TPI0@1239|Firmicutes,247QR@186801|Clostridia,42HK9@68295|Thermoanaerobacterales	186801|Clostridia	I	Alpha/beta hydrolase family	-	-	1.11.1.10,3.1.1.24	ko:K00433,ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
YHH3_k127_1556686_0	1236689.MMALV_08560	4.687e-29	130.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,3F2IN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	HELICc2	rad3b	-	3.6.4.12	ko:K03722,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2,ResIII
YHH3_k127_1579254_0	497964.CfE428DRAFT_4431	1.469e-11	78.0	COG1361@1|root,COG1520@1|root,COG1572@1|root,COG3227@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1572@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	-	-	ko:K20274	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	CHU_C,FTP,PQQ_2,Peptidase_M36
YHH3_k127_1579254_2	1445613.JALM01000064_gene1344	2.857e-06	61.0	COG5426@1|root,COG5426@2|Bacteria,2GKG4@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1579254_1	1329516.JPST01000003_gene1130	4.925e-09	70.0	COG4085@1|root,COG4085@2|Bacteria,1TSI3@1239|Firmicutes,4HAWG@91061|Bacilli	91061|Bacilli	N	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
YHH3_k127_1598234_1	1337936.IJ00_14950	2.201e-30	124.0	COG2304@1|root,COG2304@2|Bacteria,1GD1R@1117|Cyanobacteria	1117|Cyanobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
YHH3_k127_1598234_2	877455.Metbo_1928	7.539e-10	64.0	COG2164@1|root,arCOG04488@2157|Archaea	2157|Archaea	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
YHH3_k127_1598234_0	555079.Toce_2001	1.734e-163	522.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
YHH3_k127_1612337_1	533240.CRC_00003	0.0009976	49.0	COG1520@1|root,COG2304@1|root,COG2931@1|root,COG5164@1|root,COG1520@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG5164@2|Bacteria,1GPZZ@1117|Cyanobacteria,1HJUW@1161|Nostocales	1117|Cyanobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,VWA
YHH3_k127_1612337_0	273075.Ta0351	2.258e-18	90.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
YHH3_k127_1627442_1	1297742.A176_07618	2.631e-07	55.0	COG1526@1|root,COG1763@1|root,COG1526@2|Bacteria,COG1763@2|Bacteria,1NRU0@1224|Proteobacteria,42PRH@68525|delta/epsilon subdivisions,2WPXH@28221|Deltaproteobacteria,2YV87@29|Myxococcales	28221|Deltaproteobacteria	CH	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ,MobB
YHH3_k127_1627442_0	391623.TERMP_01581	2.621e-63	226.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,244E3@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_164689_0	470145.BACCOP_00223	1.531e-79	280.0	COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,2FNPZ@200643|Bacteroidia,4AN9J@815|Bacteroidaceae	976|Bacteroidetes	H	C-5 cytosine-specific DNA methylase	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
YHH3_k127_164689_2	32264.tetur03g08580.1	2.661e-07	64.0	COG1100@1|root,KOG0071@2759|Eukaryota,38I0U@33154|Opisthokonta,3BFEV@33208|Metazoa,3CVC3@33213|Bilateria,41X5Z@6656|Arthropoda	33208|Metazoa	U	Belongs to the small GTPase superfamily. Arf family	ARF6	GO:0000003,GO:0000166,GO:0000280,GO:0000768,GO:0000910,GO:0001505,GO:0001654,GO:0001726,GO:0001745,GO:0001882,GO:0001883,GO:0001889,GO:0002682,GO:0003674,GO:0003824,GO:0003924,GO:0003956,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0005938,GO:0006464,GO:0006471,GO:0006807,GO:0006810,GO:0006836,GO:0006897,GO:0006915,GO:0006949,GO:0006996,GO:0007010,GO:0007049,GO:0007112,GO:0007140,GO:0007154,GO:0007155,GO:0007163,GO:0007267,GO:0007268,GO:0007269,GO:0007275,GO:0007276,GO:0007283,GO:0007399,GO:0007423,GO:0007520,GO:0007610,GO:0008064,GO:0008104,GO:0008150,GO:0008152,GO:0008219,GO:0009636,GO:0009653,GO:0009887,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009898,GO:0009966,GO:0009987,GO:0010008,GO:0010033,GO:0010511,GO:0010512,GO:0010513,GO:0010562,GO:0010563,GO:0010638,GO:0010646,GO:0010721,GO:0010975,GO:0010977,GO:0012501,GO:0012505,GO:0014902,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016323,GO:0016324,GO:0016462,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019216,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019953,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023061,GO:0030010,GO:0030029,GO:0030030,GO:0030031,GO:0030036,GO:0030100,GO:0030139,GO:0030154,GO:0030175,GO:0030496,GO:0030534,GO:0030832,GO:0030833,GO:0030838,GO:0030865,GO:0030866,GO:0031090,GO:0031252,GO:0031253,GO:0031256,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0031344,GO:0031345,GO:0031347,GO:0031410,GO:0031527,GO:0031529,GO:0031982,GO:0031996,GO:0032153,GO:0032154,GO:0032155,GO:0032271,GO:0032273,GO:0032386,GO:0032388,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032587,GO:0032879,GO:0032880,GO:0032940,GO:0032956,GO:0032970,GO:0033028,GO:0033036,GO:0033043,GO:0033157,GO:0033206,GO:0033365,GO:0034121,GO:0034143,GO:0034394,GO:0034613,GO:0035020,GO:0035639,GO:0036010,GO:0036094,GO:0036211,GO:0036465,GO:0042221,GO:0042493,GO:0042692,GO:0042886,GO:0042995,GO:0043167,GO:0043168,GO:0043170,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043254,GO:0043412,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0045088,GO:0045177,GO:0045184,GO:0045471,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0045806,GO:0045833,GO:0045834,GO:0045936,GO:0045937,GO:0046578,GO:0046677,GO:0046889,GO:0046890,GO:0046903,GO:0046907,GO:0047485,GO:0048149,GO:0048232,GO:0048259,GO:0048261,GO:0048285,GO:0048488,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048592,GO:0048609,GO:0048646,GO:0048699,GO:0048731,GO:0048732,GO:0048749,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050773,GO:0050776,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051051,GO:0051055,GO:0051056,GO:0051093,GO:0051128,GO:0051129,GO:0051130,GO:0051146,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051241,GO:0051301,GO:0051321,GO:0051489,GO:0051493,GO:0051495,GO:0051641,GO:0051649,GO:0051704,GO:0051960,GO:0051961,GO:0055037,GO:0055038,GO:0060284,GO:0060341,GO:0060491,GO:0060627,GO:0060998,GO:0061008,GO:0061061,GO:0061640,GO:0065007,GO:0065008,GO:0070201,GO:0070727,GO:0071071,GO:0071072,GO:0071073,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0090066,GO:0090087,GO:0090162,GO:0090316,GO:0090543,GO:0090596,GO:0097159,GO:0097178,GO:0097284,GO:0097305,GO:0097367,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098590,GO:0098592,GO:0098657,GO:0098805,GO:0098858,GO:0098916,GO:0099003,GO:0099504,GO:0099536,GO:0099537,GO:0099568,GO:0099643,GO:0110053,GO:0120025,GO:0120031,GO:0120032,GO:0120035,GO:0120036,GO:0120038,GO:0140013,GO:1901265,GO:1901363,GO:1901564,GO:1901700,GO:1902531,GO:1902646,GO:1902647,GO:1902648,GO:1902903,GO:1902905,GO:1903046,GO:1903076,GO:1903078,GO:1903725,GO:1903726,GO:1903727,GO:1903827,GO:1903828,GO:1903829,GO:1904019,GO:1904375,GO:1904377,GO:1904951,GO:1905475,GO:1905477,GO:1905749,GO:1905751,GO:2000008,GO:2000009,GO:2000026,GO:2000171	-	ko:K07941	ko04014,ko04072,ko04144,ko04666,map04014,map04072,map04144,map04666	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Arf
YHH3_k127_164689_1	384616.Pisl_0558	3.528e-47	187.0	COG1236@1|root,arCOG00541@2157|Archaea,2XPVA@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
YHH3_k127_1685440_1	1089553.Tph_c15740	3.574e-10	62.0	COG4231@1|root,COG4231@2|Bacteria,1UN0W@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_1685440_0	5786.XP_003284516.1	1.315e-11	75.0	2ACI6@1|root,2RYRD@2759|Eukaryota,3XEYE@554915|Amoebozoa	554915|Amoebozoa	S	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
YHH3_k127_171256_0	589924.Ferp_0942	4.416e-38	155.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
YHH3_k127_1745365_0	1210908.HSB1_42480	8.446e-58	230.0	COG2304@1|root,arCOG07561@1|root,arCOG02902@2157|Archaea,arCOG07561@2157|Archaea,2XUQK@28890|Euryarchaeota,23TQB@183963|Halobacteria	183963|Halobacteria	K	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1748292_4	1293048.CBMB010000004_gene1689	5.784e-13	74.0	arCOG08981@1|root,arCOG08981@2157|Archaea,2Y00W@28890|Euryarchaeota,23Y5Q@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1748292_2	1220534.B655_2108	2.585e-31	126.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
YHH3_k127_1748292_1	937777.Deipe_3112	2.112e-39	159.0	COG2041@1|root,COG2041@2|Bacteria,1WI25@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
YHH3_k127_1748292_3	633148.Tagg_0582	1.782e-16	81.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
YHH3_k127_1752962_0	926569.ANT_09280	1.399e-48	178.0	COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi	926569.ANT_09280|-	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1752962_1	649638.Trad_2631	1.042e-07	59.0	COG1647@1|root,COG1647@2|Bacteria,1WKS3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_176625_0	1122173.AXVL01000004_gene812	1.654e-29	132.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
YHH3_k127_1778319_0	42256.RradSPS_1698	1.077e-08	68.0	COG0714@1|root,COG2304@1|root,COG0714@2|Bacteria,COG2304@2|Bacteria,2GMBP@201174|Actinobacteria,4CSC9@84995|Rubrobacteria	84995|Rubrobacteria	O	COG COG0714 MoxR-like ATPases General function prediction only	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
YHH3_k127_1788398_0	1304284.L21TH_2322	3.658e-52	196.0	COG0789@1|root,COG0789@2|Bacteria,1UPFX@1239|Firmicutes,24VIV@186801|Clostridia	186801|Clostridia	K	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1788398_2	694429.Pyrfu_0610	3.055e-12	72.0	COG2402@1|root,arCOG04502@2157|Archaea,2XSKX@28889|Crenarchaeota	28889|Crenarchaeota	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
YHH3_k127_1788398_3	797303.Natpe_0023	0.0009014	46.0	arCOG07990@1|root,arCOG07990@2157|Archaea,2XZBP@28890|Euryarchaeota,23X0K@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_1788398_1	220341.16504112	1.381e-12	73.0	COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,1S4JD@1236|Gammaproteobacteria,3ZMNH@590|Salmonella	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. A site-specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Its toxic effects are neutralized by expression of cognate antitoxin VapB	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
YHH3_k127_1798920_0	1243664.CAVL020000008_gene4214	1.03e-37	156.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
YHH3_k127_1798920_1	272569.rrnAC2554	2.53e-24	108.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,23VAQ@183963|Halobacteria	183963|Halobacteria	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	ACT
YHH3_k127_1798920_2	279010.BL00151	4.516e-12	73.0	COG1247@1|root,COG1247@2|Bacteria,1V3V3@1239|Firmicutes,4HHNY@91061|Bacilli,1ZFR7@1386|Bacillus	91061|Bacilli	M	COG1247 Sortase and related acyltransferases	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
YHH3_k127_1800186_1	1234664.AMRO01000079_gene569	8.24e-23	114.0	COG1525@1|root,COG3204@1|root,COG1525@2|Bacteria,COG3204@2|Bacteria,1V7X8@1239|Firmicutes,4HJJI@91061|Bacilli,1WH7K@129337|Geobacillus	91061|Bacilli	L	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	LTD,SNase
YHH3_k127_1800186_2	526225.Gobs_1101	1.075e-10	75.0	COG4733@1|root,COG4733@2|Bacteria,2HH13@201174|Actinobacteria,4EW6W@85013|Frankiales	201174|Actinobacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
YHH3_k127_1800186_0	224325.AF_1350	1.554e-27	123.0	COG0491@1|root,arCOG00504@2157|Archaea,2XYKN@28890|Euryarchaeota,246C0@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_1800186_3	351160.RCIX74	4.364e-09	68.0	COG0457@1|root,arCOG03032@2157|Archaea,2Y7M7@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
YHH3_k127_1800186_4	1169144.KB910952_gene3212	6.12e-06	57.0	COG1011@1|root,COG1011@2|Bacteria,1TRP5@1239|Firmicutes,4HBSP@91061|Bacilli,1ZDNA@1386|Bacillus	91061|Bacilli	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
YHH3_k127_1881038_0	1229909.NSED_07310	1.987e-106	366.0	COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
YHH3_k127_1914685_6	631454.N177_3038	4.579e-23	105.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TVAX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
YHH3_k127_1914685_4	498848.TaqDRAFT_3429	7.382e-36	147.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
YHH3_k127_1914685_1	985053.VMUT_2008	3.313e-59	213.0	COG1402@1|root,arCOG04536@2157|Archaea,2XQVG@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
YHH3_k127_1914685_5	1343739.PAP_07315	4.807e-28	124.0	COG0500@1|root,arCOG01791@2157|Archaea,2XZTQ@28890|Euryarchaeota,245BV@183968|Thermococci	183968|Thermococci	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
YHH3_k127_1914685_3	635013.TherJR_1090	3.043e-53	192.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,262HG@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH3_k127_1914685_0	272557.APE_1432	1.52e-170	560.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
YHH3_k127_1914685_2	272844.PAB0581	1.212e-54	199.0	COG0624@1|root,arCOG01107@2157|Archaea,2Y315@28890|Euryarchaeota,242ZX@183968|Thermococci	183968|Thermococci	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
YHH3_k127_1932394_0	1033810.HLPCO_002262	6.801e-62	231.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	ko:K06889,ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase,Malectin,Peptidase_S9
YHH3_k127_193961_0	255470.cbdbA785	4.204e-50	185.0	COG1233@1|root,COG1233@2|Bacteria,2G5ZA@200795|Chloroflexi,34D93@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
YHH3_k127_1976655_0	56780.SYN_02526	5.099e-70	244.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,42SXH@68525|delta/epsilon subdivisions,2WP5D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
YHH3_k127_1987974_0	1121930.AQXG01000014_gene384	1.196e-106	377.0	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes,1IPU7@117747|Sphingobacteriia	976|Bacteroidetes	S	COG2366 Protein related to penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
YHH3_k127_2019411_0	985053.VMUT_0238	5.707e-112	372.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
YHH3_k127_2019411_2	742818.HMPREF9451_01530	1.204e-07	63.0	2C19R@1|root,32V2R@2|Bacteria,2HUR1@201174|Actinobacteria,4CVEH@84998|Coriobacteriia	84998|Coriobacteriia	S	Protein of unknown function (DUF2797)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2797
YHH3_k127_2019411_1	667014.Thein_1052	2.169e-51	190.0	COG0535@1|root,COG0535@2|Bacteria,2GI7P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Radical_SAM
YHH3_k127_2022774_1	1033806.HTIA_0884	7.524e-22	106.0	arCOG02387@1|root,arCOG02387@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
YHH3_k127_2022774_0	471853.Bcav_1707	3.98e-41	162.0	COG4409@1|root,COG4409@2|Bacteria,2GKYI@201174|Actinobacteria	201174|Actinobacteria	G	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
YHH3_k127_2023264_1	642492.Clole_0288	2.402e-32	141.0	COG0330@1|root,COG0330@2|Bacteria,1VT4N@1239|Firmicutes	1239|Firmicutes	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
YHH3_k127_2023264_3	706587.Desti_3015	9.777e-19	87.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,42VCF@68525|delta/epsilon subdivisions,2WRI6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
YHH3_k127_2023264_2	324925.Ppha_0031	1.25e-22	101.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06039,ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE
YHH3_k127_2023264_0	304371.MCP_1615	8.042e-41	171.0	COG2202@1|root,arCOG02353@1|root,arCOG02353@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
YHH3_k127_2023264_4	649639.Bcell_0317	3.564e-17	85.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,4HJ09@91061|Bacilli,1ZGIM@1386|Bacillus	91061|Bacilli	K	transcriptional	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
YHH3_k127_2028504_1	1094980.Mpsy_2342	1.375e-27	126.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
YHH3_k127_2028504_0	1121289.JHVL01000030_gene421	1.873e-30	124.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,36ESG@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
YHH3_k127_206098_0	1365176.N186_07805	1.448e-09	70.0	COG2159@1|root,arCOG01931@2157|Archaea	2157|Archaea	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	4.1.1.52	ko:K07045,ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
YHH3_k127_2072173_0	679926.Mpet_2685	1.715e-75	261.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,2NADB@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
YHH3_k127_2072173_2	1041930.Mtc_0543	3.783e-25	118.0	COG0438@1|root,arCOG01411@2157|Archaea,2Y8C1@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
YHH3_k127_2072173_1	1173027.Mic7113_3715	1.732e-62	221.0	COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,1H8MW@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
YHH3_k127_2096611_0	756499.Desde_0778	1.135e-19	93.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
YHH3_k127_2096611_1	44056.XP_009038459.1	0.0002366	51.0	COG1231@1|root,KOG0084@1|root,KOG0029@2759|Eukaryota,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	ZDS	GO:0000003,GO:0000139,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005911,GO:0006629,GO:0006720,GO:0006721,GO:0006810,GO:0006888,GO:0007275,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009506,GO:0009507,GO:0009509,GO:0009526,GO:0009536,GO:0009555,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0012505,GO:0016020,GO:0016043,GO:0016049,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016119,GO:0016120,GO:0016192,GO:0016491,GO:0016627,GO:0016635,GO:0022414,GO:0030054,GO:0030154,GO:0031090,GO:0031967,GO:0031975,GO:0031984,GO:0032501,GO:0032502,GO:0032588,GO:0032989,GO:0040007,GO:0042175,GO:0042214,GO:0042221,GO:0042440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0044706,GO:0046148,GO:0046246,GO:0046686,GO:0046907,GO:0048193,GO:0048229,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051704,GO:0052886,GO:0052889,GO:0055044,GO:0055114,GO:0060560,GO:0071704,GO:0071840,GO:0071944,GO:0098588,GO:0098791,GO:0098827,GO:1901175,GO:1901177,GO:1901576	1.3.5.6	ko:K00514,ko:K07874	ko00906,ko01100,ko01110,ko05134,map00906,map01100,map01110,map05134	M00097	R04798,R04800,R07511,R09656,R09658	RC01214,RC01959	ko00000,ko00001,ko00002,ko01000,ko04031,ko04131,ko04147	-	-	iRC1080.CRv4_Au5_s7_g13718_t1	Amino_oxidase,Ras
YHH3_k127_210105_1	533240.CRC_00003	9.66e-08	61.0	COG1520@1|root,COG2304@1|root,COG2931@1|root,COG5164@1|root,COG1520@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG5164@2|Bacteria,1GPZZ@1117|Cyanobacteria,1HJUW@1161|Nostocales	1117|Cyanobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,VWA
YHH3_k127_210105_0	387631.Asulf_00521	7.14e-31	142.0	COG3979@1|root,COG5306@1|root,arCOG02420@1|root,arCOG03511@1|root,arCOG03553@1|root,arCOG09173@1|root,arCOG02420@2157|Archaea,arCOG03508@2157|Archaea,arCOG03511@2157|Archaea,arCOG03553@2157|Archaea,arCOG07581@2157|Archaea,arCOG09173@2157|Archaea	2157|Archaea	C	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF2341,PKD,Pilin_N,S_layer_C
YHH3_k127_2110218_9	192952.MM_1029	2.388e-31	129.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
YHH3_k127_2110218_12	195522.BD01_0919	4.398e-18	93.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2434N@183968|Thermococci	183968|Thermococci	L	Segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
YHH3_k127_2110218_0	1343739.PAP_06100	6.375e-175	592.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
YHH3_k127_2110218_16	48698.ENSPFOP00000025361	1.177e-12	81.0	29A2H@1|root,2RH4Z@2759|Eukaryota,3A03H@33154|Opisthokonta,3BPRZ@33208|Metazoa,3D1RH@33213|Bilateria,48DQ1@7711|Chordata,49AAB@7742|Vertebrata,49S45@7898|Actinopterygii	33208|Metazoa	S	Circularly permutated Ras protein 1-like	-	-	-	-	-	-	-	-	-	-	-	-	Sec23_trunk,VWA_2,zf-Sec23_Sec24
YHH3_k127_2110218_14	109760.SPPG_05221T0	3.201e-14	76.0	KOG4115@1|root,KOG4115@2759|Eukaryota,3A3F9@33154|Opisthokonta,3P6RS@4751|Fungi	4751|Fungi	DN	Dynein light chain	-	-	-	ko:K10419	-	-	-	-	ko00000,ko04131,ko04812	-	-	-	Robl_LC7
YHH3_k127_2110218_19	573063.Metin_1123	1.763e-10	67.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota,23R2D@183939|Methanococci	183939|Methanococci	S	PFAM Roadblock LC7 family protein	-	GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
YHH3_k127_2110218_8	1330700.JQNC01000003_gene522	9.444e-36	143.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
YHH3_k127_2110218_10	1123499.KB908018_gene2013	7.267e-29	119.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria,2KREG@206351|Neisseriales	206351|Neisseriales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
YHH3_k127_2110218_4	573063.Metin_0747	7.105e-86	292.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,23Q8C@183939|Methanococci	183939|Methanococci	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
YHH3_k127_2110218_6	195522.BD01_1055	1.407e-73	255.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,242R3@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
YHH3_k127_2110218_1	1343739.PAP_05870	6.208e-121	404.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
YHH3_k127_2110218_5	264732.Moth_0446	2.743e-74	261.0	COG1856@1|root,COG1856@2|Bacteria,1V23U@1239|Firmicutes,24E3M@186801|Clostridia,42GSP@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
YHH3_k127_2110218_17	386456.JQKN01000001_gene1644	8.842e-11	69.0	arCOG06453@1|root,arCOG06453@2157|Archaea,2XZAX@28890|Euryarchaeota,23P5V@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2110218_15	1151117.AJLF01000001_gene1131	1.398e-13	74.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
YHH3_k127_2110218_3	386456.JQKN01000001_gene1642	2.254e-86	295.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
YHH3_k127_2110218_11	240016.ABIZ01000001_gene5499	1.054e-26	128.0	COG2931@1|root,COG3203@1|root,COG3266@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3203@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,46VKK@74201|Verrucomicrobia,2IW2X@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
YHH3_k127_2110218_2	247490.KSU1_C0714	9.966e-87	318.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
YHH3_k127_2110218_13	330214.NIDE3577	1.102e-17	92.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	3.4.14.13	ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Glycos_transf_2
YHH3_k127_2110218_7	1187851.A33M_0279	1.599e-43	160.0	COG4177@1|root,COG4177@2|Bacteria,1NE3E@1224|Proteobacteria,2TTWY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
YHH3_k127_2120658_4	1343739.PAP_03255	4.108e-124	411.0	COG0374@1|root,arCOG01549@2157|Archaea,2Y2IM@28890|Euryarchaeota,2434B@183968|Thermococci	183968|Thermococci	C	Nickel-dependent hydrogenase	-	-	1.12.1.3,1.12.1.5	ko:K17993	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
YHH3_k127_2120658_5	195522.BD01_0438	1.575e-90	305.0	COG1941@1|root,arCOG02472@2157|Archaea,2XZ11@28890|Euryarchaeota,242UJ@183968|Thermococci	183968|Thermococci	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.3,1.12.1.5	ko:K17994	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
YHH3_k127_2120658_3	1042877.GQS_02465	2.265e-125	410.0	COG0543@1|root,arCOG02199@2157|Archaea,2XXQZ@28890|Euryarchaeota,2431P@183968|Thermococci	183968|Thermococci	C	Oxidoreductase FAD-binding domain	hydG	-	1.12.98.4	ko:K17995	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
YHH3_k127_2120658_1	1343739.PAP_03240	7.094e-141	456.0	COG1145@1|root,arCOG05128@2157|Archaea,2Y359@28890|Euryarchaeota,2432K@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	hydB	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
YHH3_k127_2120658_0	429009.Adeg_1885	1.41e-204	673.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
YHH3_k127_2122730_0	293826.Amet_0759	2.774e-35	139.0	COG1053@1|root,COG3976@1|root,COG1053@2|Bacteria,COG3976@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,36DR3@31979|Clostridiaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
YHH3_k127_2122730_1	589924.Ferp_1169	2.884e-26	119.0	COG0683@1|root,arCOG01020@2157|Archaea,2XTSF@28890|Euryarchaeota,24631@183980|Archaeoglobi	28890|Euryarchaeota	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6,TAT_signal
YHH3_k127_2151349_1	500635.MITSMUL_04088	1.085e-05	59.0	COG0675@1|root,COG0675@2|Bacteria,1V0IB@1239|Firmicutes,4H945@909932|Negativicutes	1239|Firmicutes	L	Putative transposase DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_2151349_0	195103.CPF_2585	5.813e-22	99.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
YHH3_k127_2151784_1	1378168.N510_01701	7.678e-11	66.0	COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes	1239|Firmicutes	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
YHH3_k127_2151784_0	267748.MMOB5660	2.146e-12	78.0	COG0462@1|root,COG0462@2|Bacteria,3WSZG@544448|Tenericutes	544448|Tenericutes	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
YHH3_k127_215601_2	933801.Ahos_1505	4.524e-13	76.0	COG1695@1|root,arCOG00002@2157|Archaea,2XRBK@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
YHH3_k127_215601_1	1521187.JPIM01000086_gene735	6.923e-89	316.0	COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi,3758C@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_215601_0	697281.Mahau_0232	6.218e-98	348.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42EQB@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_219094_0	579137.Metvu_0790	5.371e-153	498.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
YHH3_k127_219094_1	1121097.JCM15093_1322	3.649e-75	267.0	COG2407@1|root,COG2407@2|Bacteria,4P1BT@976|Bacteroidetes,2FMIE@200643|Bacteroidia,4AKFB@815|Bacteroidaceae	976|Bacteroidetes	G	COG2407 L-fucose isomerase and related	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2197784_0	1382359.JIAL01000001_gene923	1.379e-11	72.0	COG3170@1|root,COG4409@1|root,COG5306@1|root,COG3170@2|Bacteria,COG4409@2|Bacteria,COG5306@2|Bacteria,3Y2GG@57723|Acidobacteria,2JI5J@204432|Acidobacteriia	2|Bacteria	G	Belongs to the peptidase S8 family	exbB2	-	-	ko:K03561,ko:K12287,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000,ko02044	1.A.30.2.1	-	-	Big_3_2,DUF2341,Laminin_G_3,MotA_ExbB
YHH3_k127_2201520_0	439481.Aboo_0196	2.555e-09	67.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,3F2IN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	HELICc2	rad3b	-	3.6.4.12	ko:K03722,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2,ResIII
YHH3_k127_2204924_0	545697.HMPREF0216_00098	1.734e-135	460.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,36EIK@31979|Clostridiaceae	186801|Clostridia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
YHH3_k127_2204924_1	604354.TSIB_1725	3.275e-97	325.0	arCOG06481@1|root,arCOG06481@2157|Archaea,2XV5Y@28890|Euryarchaeota,24471@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2227576_3	374847.Kcr_0334	4.067e-37	147.0	arCOG06048@1|root,arCOG06048@2157|Archaea	374847.Kcr_0334|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2227576_2	397948.Cmaq_1824	3.128e-49	190.0	COG3535@1|root,arCOG03841@2157|Archaea,2XQ5C@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
YHH3_k127_2227576_4	935840.JAEQ01000021_gene4394	2.295e-32	136.0	COG4126@1|root,COG4126@2|Bacteria,1MVNB@1224|Proteobacteria,2U28G@28211|Alphaproteobacteria,43K4C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Hydantoin racemase	-	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
YHH3_k127_2227576_5	1033734.CAET01000065_gene2167	1.471e-13	83.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
YHH3_k127_2227576_1	411467.BACCAP_01345	2.213e-55	207.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
YHH3_k127_2227576_0	574087.Acear_1487	1.667e-60	221.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_2228491_1	913865.DOT_0091	1.076e-71	256.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
YHH3_k127_2228491_0	635013.TherJR_1222	6.039e-74	271.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,266U6@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
YHH3_k127_2228491_2	518766.Rmar_1788	5.243e-45	171.0	COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,1FIPW@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_2228491_4	1123288.SOV_5c02920	7.906e-15	83.0	COG2386@1|root,COG2386@2|Bacteria,1V4VJ@1239|Firmicutes,4H4I4@909932|Negativicutes	909932|Negativicutes	O	CcmB protein	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
YHH3_k127_2228491_3	1051632.TPY_3397	1.19e-37	149.0	COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,24IWH@186801|Clostridia	186801|Clostridia	O	PFAM Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
YHH3_k127_2228491_6	986075.CathTA2_0317	7.445e-07	57.0	COG2332@1|root,COG2332@2|Bacteria,1VJ83@1239|Firmicutes,4HPSQ@91061|Bacilli	91061|Bacilli	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
YHH3_k127_2228491_5	720554.Clocl_2295	1.584e-09	62.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,3WJ1H@541000|Ruminococcaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_2238039_0	453591.Igni_0025	2.257e-51	190.0	COG2414@1|root,arCOG00709@2157|Archaea,2XPTI@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_2269021_0	153721.MYP_1693	0.0004656	54.0	COG3291@1|root,COG3291@2|Bacteria,4NW5C@976|Bacteroidetes,47RYD@768503|Cytophagia	976|Bacteroidetes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
YHH3_k127_229622_5	880072.Desac_1236	6.981e-77	265.0	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,42NT2@68525|delta/epsilon subdivisions,2WJM5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Mediates zinc uptake. May also transport other divalent cations	gufA	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
YHH3_k127_229622_16	1448860.BBJO01000014_gene1188	1.849e-33	139.0	arCOG06048@1|root,arCOG06048@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_229622_10	357808.RoseRS_1410	1.723e-48	178.0	COG0667@1|root,COG0667@2|Bacteria,2G5N6@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
YHH3_k127_229622_11	661478.OP10G_4118	4.125e-45	167.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
YHH3_k127_229622_21	706434.HMPREF9429_00153	9.551e-13	72.0	2D1AQ@1|root,32TA9@2|Bacteria,1VADA@1239|Firmicutes,4H5ES@909932|Negativicutes	909932|Negativicutes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_229622_19	224325.AF_0799	6.653e-24	108.0	COG0622@1|root,arCOG01141@2157|Archaea,2XXVQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
YHH3_k127_229622_1	304371.MCP_0813	1.452e-122	421.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
YHH3_k127_229622_9	1027371.GOALK_072_00120	3.79e-55	204.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4GAT1@85026|Gordoniaceae	201174|Actinobacteria	U	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
YHH3_k127_229622_8	368408.Tpen_1575	1.219e-58	216.0	COG0111@1|root,arCOG01757@2157|Archaea	2157|Archaea	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA2	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
YHH3_k127_229622_0	368408.Tpen_0817	1.983e-149	487.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
YHH3_k127_229622_12	693661.Arcve_2003	1.323e-41	159.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,246YM@183980|Archaeoglobi	183980|Archaeoglobi	F	Nicotinamide-nucleotide adenylyltransferase	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
YHH3_k127_229622_2	342949.PNA2_0113	4.097e-103	346.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2438J@183968|Thermococci	183968|Thermococci	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.5	ko:K18105	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
YHH3_k127_229622_6	374847.Kcr_1458	4.979e-67	241.0	COG1084@1|root,arCOG00352@2157|Archaea	2157|Archaea	S	GTP-binding protein	gbp4	-	-	ko:K06883,ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
YHH3_k127_229622_17	521011.Mpal_0778	3.436e-32	132.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
YHH3_k127_229622_4	215803.DB30_1819	4.261e-77	275.0	COG1032@1|root,COG1032@2|Bacteria,1RF63@1224|Proteobacteria,42S8Y@68525|delta/epsilon subdivisions,2WNX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
YHH3_k127_229622_3	1343739.PAP_00750	1.494e-82	285.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,24362@183968|Thermococci	183968|Thermococci	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
YHH3_k127_229622_15	552811.Dehly_0767	2.381e-36	145.0	COG2178@1|root,COG2178@2|Bacteria,2G6RW@200795|Chloroflexi,34CS2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_229622_13	1183377.Py04_1099	6.992e-40	156.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,242U9@183968|Thermococci	183968|Thermococci	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,HTH_27,HTH_Crp_2,MarR_2
YHH3_k127_229622_7	415426.Hbut_0632	1.638e-63	228.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
YHH3_k127_229622_18	644281.MFS40622_0014	1.064e-25	111.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,23R2C@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
YHH3_k127_229622_14	877455.Metbo_0692	3.548e-39	152.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,23NUJ@183925|Methanobacteria	183925|Methanobacteria	J	N2,N2-dimethylguanosine tRNA methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
YHH3_k127_2313455_0	1232430.CAVG010000116_gene1061	0.0001111	54.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4HAIF@91061|Bacilli,4H091@90964|Staphylococcaceae	91061|Bacilli	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
YHH3_k127_2333688_4	864702.OsccyDRAFT_2949	1.116e-57	207.0	COG0120@1|root,COG0120@2|Bacteria,1G2DW@1117|Cyanobacteria,1H811@1150|Oscillatoriales	1117|Cyanobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.rpiA	Rib_5-P_isom_A
YHH3_k127_2333688_1	285535.JOEY01000002_gene4943	3.141e-104	349.0	COG0457@1|root,COG0457@2|Bacteria,2I7P1@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037,TPR_12
YHH3_k127_2333688_0	186497.PF1041	4.95e-119	395.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,242R1@183968|Thermococci	183968|Thermococci	V	K homology RNA-binding domain	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
YHH3_k127_2333688_6	386456.JQKN01000001_gene1826	2.816e-21	102.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,23P3J@183925|Methanobacteria	183925|Methanobacteria	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
YHH3_k127_2333688_5	386456.JQKN01000002_gene2658	2.798e-33	134.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23P79@183925|Methanobacteria	183925|Methanobacteria	C	hydrogenase maturation protease HycI	hycI	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
YHH3_k127_2333688_2	694429.Pyrfu_1298	4.611e-88	302.0	COG0182@1|root,arCOG01123@2157|Archaea,2XPZU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
YHH3_k127_2333688_7	9733.XP_004268047.1	5.097e-10	70.0	COG4886@1|root,KOG4194@2759|Eukaryota,39JK1@33154|Opisthokonta,3BDMH@33208|Metazoa,3CSI3@33213|Bilateria,4859K@7711|Chordata,494NT@7742|Vertebrata,3JEGJ@40674|Mammalia,4J0SS@91561|Cetartiodactyla	33208|Metazoa	T	leucine-rich repeats and immunoglobulin-like domains	LRIG1	GO:0003008,GO:0003674,GO:0005102,GO:0005114,GO:0005126,GO:0005160,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007275,GO:0007399,GO:0007423,GO:0007600,GO:0007605,GO:0008150,GO:0009653,GO:0009719,GO:0009790,GO:0009887,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010453,GO:0010470,GO:0010646,GO:0010647,GO:0016020,GO:0016021,GO:0017015,GO:0021675,GO:0022404,GO:0022405,GO:0022603,GO:0023051,GO:0023052,GO:0023056,GO:0030511,GO:0031224,GO:0031226,GO:0032474,GO:0032501,GO:0032502,GO:0034713,GO:0040008,GO:0040014,GO:0040018,GO:0042221,GO:0042303,GO:0042471,GO:0042472,GO:0042633,GO:0042659,GO:0042661,GO:0043583,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045927,GO:0045995,GO:0048513,GO:0048518,GO:0048522,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048638,GO:0048639,GO:0048731,GO:0048839,GO:0048840,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050877,GO:0050896,GO:0050954,GO:0051094,GO:0051239,GO:0051240,GO:0051716,GO:0060384,GO:0065007,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0071944,GO:0090092,GO:0090100,GO:0090287,GO:0090596,GO:1903844,GO:1903846,GO:1905770,GO:1905902,GO:2000026,GO:2000027,GO:2000380	-	-	-	-	-	-	-	-	-	-	I-set,Ig_3,LRRCT,LRRNT,LRR_8
YHH3_k127_2333688_3	215803.DB30_8551	1.103e-84	293.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WME2@28221|Deltaproteobacteria,2YWHE@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_2343988_1	315730.BcerKBAB4_4367	4.27e-23	100.0	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli,1ZIX5@1386|Bacillus	91061|Bacilli	S	Uncharacterized conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
YHH3_k127_2343988_0	56110.Oscil6304_5498	1.219e-53	199.0	COG0384@1|root,COG0384@2|Bacteria,1G0Y0@1117|Cyanobacteria,1H7VM@1150|Oscillatoriales	1117|Cyanobacteria	S	TIGRFAM phenazine biosynthesis protein PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
YHH3_k127_2369894_0	1455608.JDTH01000006_gene2542	9.55e-10	61.0	COG0784@1|root,arCOG02387@1|root,arCOG02333@2157|Archaea,arCOG02387@2157|Archaea,2XST7@28890|Euryarchaeota,23S1Y@183963|Halobacteria	183963|Halobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
YHH3_k127_2385584_2	1125863.JAFN01000001_gene2593	5.75e-63	225.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
YHH3_k127_2385584_0	1047013.AQSP01000095_gene2313	1.056e-91	313.0	COG3804@1|root,COG3804@2|Bacteria,2NP85@2323|unclassified Bacteria	2|Bacteria	S	dihydrodipicolinate reductase	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.16,1.4.1.26	ko:K03340,ko:K21672	ko00300,ko00310,ko00330,ko00472,ko01100,ko01110,ko01230,map00300,map00310,map00330,map00472,map01100,map01110,map01230	M00526	R02755,R02825,R04200,R04201,R04687,R04688	RC00006,RC00249,RC00790	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N
YHH3_k127_2385584_1	1048834.TC41_0663	1.858e-65	230.0	COG0675@1|root,COG0675@2|Bacteria,1TRNY@1239|Firmicutes,4HD8I@91061|Bacilli,2795V@186823|Alicyclobacillaceae	91061|Bacilli	L	Helix-turn-helix domain	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_2385584_4	391625.PPSIR1_06376	2.151e-21	106.0	COG5276@1|root,COG5276@2|Bacteria,1RBM1@1224|Proteobacteria,42TF9@68525|delta/epsilon subdivisions,2WPX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
YHH3_k127_2385584_3	1284352.AOIG01000013_gene3550	1.046e-39	163.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
YHH3_k127_2393031_0	1191523.MROS_1378	2.056e-170	544.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
YHH3_k127_2393031_1	1410674.JNKU01000006_gene1630	0.000173	47.0	COG1522@1|root,COG1522@2|Bacteria,1V2P9@1239|Firmicutes,4HI2F@91061|Bacilli	91061|Bacilli	K	AsnC family transcriptional regulator	lrp3	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_2399144_2	439235.Dalk_4976	1.221e-05	48.0	COG1145@1|root,COG1145@2|Bacteria,1MW11@1224|Proteobacteria,42NUY@68525|delta/epsilon subdivisions,2WK01@28221|Deltaproteobacteria,2MMY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_2399144_1	1125699.HMPREF9194_02144	1.14e-28	131.0	COG1432@1|root,COG1432@2|Bacteria,2J6SB@203691|Spirochaetes	203691|Spirochaetes	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
YHH3_k127_2399144_0	443144.GM21_1812	4.392e-51	195.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,43T3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
YHH3_k127_2419387_1	1121324.CLIT_4c01440	5.866e-28	119.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,24EED@186801|Clostridia	186801|Clostridia	F	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
YHH3_k127_2419387_2	439481.Aboo_1541	2.683e-12	71.0	COG1977@1|root,arCOG00536@2157|Archaea,2Y6GJ@28890|Euryarchaeota,3F3IT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
YHH3_k127_2419387_0	563008.HMPREF0665_01844	6.517e-29	127.0	COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,2FM38@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
YHH3_k127_2457251_1	269797.Mbar_A0881	1.884e-67	242.0	COG1035@1|root,COG3350@1|root,arCOG02650@2157|Archaea,arCOG04507@2157|Archaea,2Y7JA@28890|Euryarchaeota,2NAMA@224756|Methanomicrobia	224756|Methanomicrobia	C	YHS domain	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N,YHS
YHH3_k127_2457251_0	290397.Adeh_0508	4.09e-71	248.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria,2YV7W@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
YHH3_k127_2480398_9	224719.Abm4_1417	9.663e-23	109.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,23NQ0@183925|Methanobacteria	183925|Methanobacteria	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
YHH3_k127_2480398_7	1094980.Mpsy_2035	8.205e-29	128.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
YHH3_k127_2480398_4	573063.Metin_1141	1.331e-51	188.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,23QUS@183939|Methanococci	183939|Methanococci	C	TIGRFAM archaeoflavoprotein AfpA	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
YHH3_k127_2480398_6	660470.Theba_2249	3.87e-37	149.0	COG2820@1|root,COG2820@2|Bacteria,2GCK2@200918|Thermotogae	200918|Thermotogae	F	PFAM purine or other phosphorylase family 1	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
YHH3_k127_2480398_1	1131266.ARWQ01000001_gene1315	1.884e-92	316.0	COG0863@1|root,arCOG00890@2157|Archaea	2157|Archaea	L	PFAM DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00590,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase,UPF0020
YHH3_k127_2480398_0	1121342.AUCO01000004_gene608	2.601e-95	321.0	COG0863@1|root,COG0863@2|Bacteria,1TR56@1239|Firmicutes,248NR@186801|Clostridia	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
YHH3_k127_2480398_5	697281.Mahau_1403	1.434e-44	177.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia,42GGS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
YHH3_k127_2480398_3	926569.ANT_16930	2.391e-61	224.0	COG2234@1|root,COG2234@2|Bacteria,2G6WJ@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
YHH3_k127_2480398_8	946362.XP_004987796.1	2.018e-28	125.0	KOG0266@1|root,KOG0271@1|root,KOG0272@1|root,KOG0266@2759|Eukaryota,KOG0271@2759|Eukaryota,KOG0272@2759|Eukaryota,38B6D@33154|Opisthokonta	33154|Opisthokonta	D	thiol-dependent ubiquitin-specific protease activity	-	-	-	-	-	-	-	-	-	-	-	-	WD40
YHH3_k127_2480398_10	1158318.ATXC01000001_gene729	1.089e-14	87.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_2480398_2	1230338.MOMA_04280	1.548e-70	243.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,3NJQV@468|Moraxellaceae	1236|Gammaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
YHH3_k127_2498843_0	439481.Aboo_1085	1.82e-162	527.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,3F2HC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Radical_SAM C-terminal domain	elp3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
YHH3_k127_2498843_1	574087.Acear_1505	1.313e-75	261.0	COG0778@1|root,COG0778@2|Bacteria,1UZC3@1239|Firmicutes,24BKG@186801|Clostridia,3WBQ2@53433|Halanaerobiales	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
YHH3_k127_2498843_4	1006006.Mcup_1937	1.305e-27	117.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
YHH3_k127_2498843_2	1459636.NTE_01837	1.07e-45	176.0	COG2106@1|root,arCOG04069@2157|Archaea,41SI7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
YHH3_k127_2498843_3	1499967.BAYZ01000105_gene3489	2.42e-33	130.0	COG1882@1|root,COG1882@2|Bacteria,2NQDK@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate formate lyase-like	pflD	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
YHH3_k127_2499466_2	760568.Desku_1392	1.168e-28	120.0	COG2267@1|root,COG2267@2|Bacteria,1V4GY@1239|Firmicutes,25EJZ@186801|Clostridia,261ST@186807|Peptococcaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
YHH3_k127_2499466_3	1123257.AUFV01000007_gene297	2.395e-28	118.0	COG4319@1|root,COG4319@2|Bacteria,1NHKV@1224|Proteobacteria,1T8CF@1236|Gammaproteobacteria,1XAF3@135614|Xanthomonadales	135614|Xanthomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
YHH3_k127_2499466_0	880073.Calab_2418	2.121e-91	317.0	COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria	2|Bacteria	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
YHH3_k127_2499466_4	1117314.PCIT_16320	0.0009201	45.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,2Q0C5@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	EP	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K12369,ko:K19227	ko01503,ko02010,map01503,map02010	M00324,M00739	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.5	-	iECUMN_1333.ECUMN_4053	BPD_transp_1
YHH3_k127_2499466_1	1304874.JAFY01000002_gene135	4.011e-45	170.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_2502942_10	485915.Dret_0856	0.0003186	50.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria,2M8Q5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
YHH3_k127_2502942_0	1047013.AQSP01000067_gene2204	3.07e-100	339.0	COG0436@1|root,COG0436@2|Bacteria,2NR19@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
YHH3_k127_2502942_8	1313421.JHBV01000015_gene5750	2.292e-08	62.0	COG5492@1|root,COG5492@2|Bacteria,4NY38@976|Bacteroidetes	976|Bacteroidetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2502942_9	525904.Tter_2660	1.824e-06	57.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.3,3.1.3.73,5.4.2.11,5.4.2.12	ko:K01834,ko:K02226,ko:K15634,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
YHH3_k127_2502942_6	237368.SCABRO_02097	1.452e-27	117.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx
YHH3_k127_2502942_7	156578.ATW7_01947	6.85e-13	74.0	2EE5F@1|root,33800@2|Bacteria,1R6R9@1224|Proteobacteria,1RRIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2502942_5	926569.ANT_26440	5.211e-30	129.0	COG0344@1|root,COG0344@2|Bacteria	2|Bacteria	I	acyl-phosphate glycerol-3-phosphate acyltransferase activity	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
YHH3_k127_2502942_2	316274.Haur_2605	1.02e-69	243.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi,375II@32061|Chloroflexia	32061|Chloroflexia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_2502942_4	858215.Thexy_0875	2.197e-33	145.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,42FNY@68295|Thermoanaerobacterales	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_2502942_1	98439.AJLL01000077_gene3097	2.676e-78	290.0	COG0344@1|root,COG0574@1|root,COG3848@1|root,COG0344@2|Bacteria,COG0574@2|Bacteria,COG3848@2|Bacteria,1G2NJ@1117|Cyanobacteria,1JH64@1189|Stigonemataceae	1117|Cyanobacteria	GT	Glycerol-3-phosphate acyltransferase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	G3P_acyltransf,PEP-utilizers,PPDK_N
YHH3_k127_2502942_3	1304880.JAGB01000002_gene1803	2.356e-69	243.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_252360_1	1158601.I585_04186	7.195e-16	81.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HEBP@91061|Bacilli,4B64Z@81852|Enterococcaceae	91061|Bacilli	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_252360_2	1280689.AUJC01000003_gene907	0.0001216	55.0	COG2898@1|root,COG2898@2|Bacteria,1U5FR@1239|Firmicutes,248XI@186801|Clostridia,36E5R@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
YHH3_k127_252360_0	1120950.KB892780_gene389	1.794e-123	415.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DN4J@85009|Propionibacteriales	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
YHH3_k127_2530552_0	1121928.AUHE01000004_gene2508	1.63e-33	135.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria,4GAD3@85026|Gordoniaceae	201174|Actinobacteria	S	CrtC N-terminal lipocalin domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
YHH3_k127_2530552_1	644966.Tmar_0659	1.271e-08	63.0	COG2318@1|root,COG2318@2|Bacteria,1VD08@1239|Firmicutes,25151@186801|Clostridia	186801|Clostridia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
YHH3_k127_2532286_1	1294143.H681_22575	6.293e-05	55.0	COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,1RPAT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	ynfM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08224	-	-	-	-	ko00000,ko02000	2.A.1.36	-	-	MFS_1,Sugar_tr
YHH3_k127_2533306_0	477974.Daud_0678	2.522e-67	237.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia,266KR@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH3_k127_2533306_2	1279009.ADICEAN_01652	2.667e-40	156.0	COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,47PUA@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
YHH3_k127_2533306_1	643867.Ftrac_0980	5.387e-49	179.0	COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,47PUA@768503|Cytophagia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
YHH3_k127_2540312_1	56780.SYN_02526	1.864e-29	121.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,42SXH@68525|delta/epsilon subdivisions,2WP5D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
YHH3_k127_2540312_0	589865.DaAHT2_2131	5.545e-110	362.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2MMVM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
YHH3_k127_2583558_0	7955.ENSDARP00000107985	2.594e-35	158.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39RKB@33154|Opisthokonta,3BK61@33208|Metazoa,3CX3T@33213|Bilateria,4872C@7711|Chordata,495PJ@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
YHH3_k127_2598677_1	1123400.KB904774_gene3283	3.648e-09	64.0	2ET0G@1|root,33KIP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2635826_0	456320.Mvol_1018	2.174e-27	117.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,23Q9N@183939|Methanococci	183939|Methanococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
YHH3_k127_2635826_1	6211.A0A068XY72	1.554e-06	55.0	KOG3341@1|root,KOG3341@2759|Eukaryota,38FCZ@33154|Opisthokonta,3B9KQ@33208|Metazoa,3CUGF@33213|Bilateria	33208|Metazoa	U	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs	SNF8	GO:0000003,GO:0000578,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031326,GO:0031410,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045921,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:1903506,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:2000112,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
YHH3_k127_2657489_3	649639.Bcell_0521	6.458e-05	56.0	COG0577@1|root,COG0577@2|Bacteria,1TSP8@1239|Firmicutes,4HDWQ@91061|Bacilli,1ZEFM@1386|Bacillus	91061|Bacilli	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_2657489_2	1306990.BARG01000031_gene3520	1.996e-05	58.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
YHH3_k127_2657489_0	693661.Arcve_1931	2.642e-66	233.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2460M@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_2657489_4	1385521.N803_04035	0.0009389	53.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4FFAH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ABC transporter	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_2657489_1	110365.A0A023B5H8	1.109e-08	67.0	KOG0080@1|root,KOG0080@2759|Eukaryota,3YA86@5794|Apicomplexa	5794|Apicomplexa	U	Rab subfamily of small GTPases	-	-	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
YHH3_k127_2661273_0	1449063.JMLS01000001_gene4321	5.801e-19	99.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,26QDE@186822|Paenibacillaceae	91061|Bacilli	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,PUCC,Sugar_tr
YHH3_k127_2661273_1	1457250.BBMO01000001_gene1619	3.264e-16	90.0	COG0642@1|root,arCOG06192@2157|Archaea,2Y7XK@28890|Euryarchaeota	28890|Euryarchaeota	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HTH_10,PAS_4,PAS_9,Response_reg
YHH3_k127_267538_0	767817.Desgi_3669	1.801e-11	70.0	COG0620@1|root,COG0620@2|Bacteria,1TQX4@1239|Firmicutes,24A5D@186801|Clostridia,260DR@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2682422_0	1487953.JMKF01000045_gene2836	4.907e-20	104.0	COG1404@1|root,COG1404@2|Bacteria,1GBNY@1117|Cyanobacteria	1117|Cyanobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_2709359_0	666510.ASAC_1316	2.149e-25	107.0	COG1171@1|root,arCOG01431@2157|Archaea,2XPZF@28889|Crenarchaeota	28889|Crenarchaeota	E	Threonine dehydratase	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
YHH3_k127_2709359_1	192952.MM_2658	1.374e-05	56.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y1G6@28890|Euryarchaeota,2NAZG@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
YHH3_k127_2726616_0	63737.Npun_F3215	1.086e-69	243.0	COG0455@1|root,COG0455@2|Bacteria,1G1EJ@1117|Cyanobacteria,1HQDQ@1161|Nostocales	1117|Cyanobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,ParA
YHH3_k127_2741828_1	97139.C824_04367	1.414e-46	174.0	COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,36UH1@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
YHH3_k127_2741828_0	243232.MJ_1504	7.875e-98	331.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,23QEM@183939|Methanococci	183939|Methanococci	M	PFAM UDP-N-acetylglucosamine 2-epimerase	-	GO:0003674,GO:0003824,GO:0008761,GO:0016853,GO:0016854,GO:0016857	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
YHH3_k127_2741828_2	795797.C497_00720	3.852e-05	47.0	arCOG02989@1|root,arCOG02989@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1931
YHH3_k127_2751435_0	1313304.CALK_0001	2.259e-94	321.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
YHH3_k127_2751435_1	1341151.ASZU01000008_gene1425	3.702e-71	249.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,27BD2@186824|Thermoactinomycetaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
YHH3_k127_2751435_2	1294142.CINTURNW_1944	3.995e-27	117.0	COG0693@1|root,COG0693@2|Bacteria,1V5HS@1239|Firmicutes,24KRV@186801|Clostridia	186801|Clostridia	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
YHH3_k127_2751435_5	456442.Mboo_1535	1.454e-07	55.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
YHH3_k127_2751435_3	543526.Htur_1021	4.233e-15	88.0	COG0642@1|root,COG2203@1|root,arCOG02352@1|root,arCOG02359@1|root,arCOG03567@1|root,arCOG02352@2157|Archaea,arCOG02358@2157|Archaea,arCOG02359@2157|Archaea,arCOG02369@2157|Archaea,arCOG03567@2157|Archaea,2XUM1@28890|Euryarchaeota,23UN4@183963|Halobacteria	183963|Halobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MEDS,PAS_3,PAS_4
YHH3_k127_2751435_4	263820.PTO1523	7.687e-10	71.0	COG1378@1|root,arCOG02038@2157|Archaea,2XUX7@28890|Euryarchaeota,24205@183967|Thermoplasmata	183967|Thermoplasmata	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
YHH3_k127_2775336_8	269797.Mbar_A2087	6.172e-54	201.0	COG1810@1|root,arCOG02468@2157|Archaea,2XU42@28890|Euryarchaeota,2NAEU@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
YHH3_k127_2775336_13	192952.MM_0060	2.143e-09	63.0	COG1153@1|root,arCOG02674@2157|Archaea,2Y4B7@28890|Euryarchaeota,2NB20@224756|Methanomicrobia	224756|Methanomicrobia	C	Molydopterin dinucleotide binding domain	-	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2923	Molydop_binding
YHH3_k127_2775336_6	1094980.Mpsy_2950	1.627e-68	249.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
YHH3_k127_2775336_1	1094980.Mpsy_2951	1.065e-197	643.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,2N9AI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
YHH3_k127_2775336_11	224325.AF_1649	3.666e-37	145.0	COG1145@1|root,arCOG00292@2157|Archaea,2XXJH@28890|Euryarchaeota,2468F@183980|Archaeoglobi	183980|Archaeoglobi	C	formylmethanofuran dehydrogenase, subunit G	-	-	-	ko:K11260	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	FeS,Fer4
YHH3_k127_2775336_10	589924.Ferp_0602	1.241e-41	169.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,245WE@183980|Archaeoglobi	183980|Archaeoglobi	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
YHH3_k127_2775336_5	868595.Desca_0350	6.633e-70	245.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia,260Q5@186807|Peptococcaceae	186801|Clostridia	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
YHH3_k127_2775336_0	593750.Metfor_1721	1.295e-308	963.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,2N9CY@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	-	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
YHH3_k127_2775336_12	456442.Mboo_1372	1.218e-32	135.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota	28890|Euryarchaeota	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
YHH3_k127_2775336_2	323259.Mhun_0688	4.63e-184	586.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	cdhC	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
YHH3_k127_2775336_4	565033.GACE_0355	1.379e-111	372.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,245TW@183980|Archaeoglobi	183980|Archaeoglobi	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
YHH3_k127_2775336_3	456442.Mboo_1369	1.066e-139	459.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
YHH3_k127_2775336_7	579137.Metvu_0345	2.474e-62	226.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota,23QPT@183939|Methanococci	183939|Methanococci	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
YHH3_k127_2775336_9	1125863.JAFN01000001_gene2044	9.53e-42	158.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
YHH3_k127_2779353_0	374847.Kcr_1153	9.077e-77	267.0	COG4046@1|root,arCOG04181@2157|Archaea	2157|Archaea	S	DUF1512 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
YHH3_k127_2779353_3	415426.Hbut_0883	5.117e-07	56.0	arCOG03770@1|root,arCOG03770@2157|Archaea,2XR27@28889|Crenarchaeota	28889|Crenarchaeota	M	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2779353_1	399549.Msed_2126	3.698e-68	242.0	COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota	28889|Crenarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
YHH3_k127_2779353_2	671065.MetMK1DRAFT_00030120	1.141e-65	232.0	COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota	28889|Crenarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
YHH3_k127_2802663_1	931277.C448_14303	4.472e-46	174.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,23UTP@183963|Halobacteria	183963|Halobacteria	J	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
YHH3_k127_2802663_0	339860.Msp_1301	3.152e-78	277.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
YHH3_k127_2802663_3	374847.Kcr_0040	0.0002493	52.0	COG4901@1|root,arCOG04327@2157|Archaea	2157|Archaea	J	30S ribosomal protein S25E	rps25e	-	-	ko:K02975	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S25
YHH3_k127_2802663_2	81985.XP_006282112.1	1.399e-11	75.0	KOG0076@1|root,KOG0076@2759|Eukaryota,37I4N@33090|Viridiplantae,3G7R4@35493|Streptophyta,3HXEF@3699|Brassicales	35493|Streptophyta	U	Belongs to the small GTPase superfamily. Arf family	-	-	-	ko:K07952	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
YHH3_k127_2860142_4	1094980.Mpsy_1000	8.444e-17	86.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota,2N9J3@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GHMP kinase	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
YHH3_k127_2860142_0	768672.Desfe_0418	1.125e-78	273.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
YHH3_k127_2860142_1	529709.PYCH_07360	4.963e-61	223.0	COG1893@1|root,arCOG04139@2157|Archaea,2XTBD@28890|Euryarchaeota,243P9@183968|Thermococci	183968|Thermococci	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
YHH3_k127_2860142_2	304371.MCP_2530	7.255e-33	136.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2N9QR@224756|Methanomicrobia	224756|Methanomicrobia	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_2860142_3	572478.Vdis_1887	2.749e-20	96.0	COG0520@1|root,arCOG00065@2157|Archaea,2XQVQ@28889|Crenarchaeota	28889|Crenarchaeota	E	Aminotransferase class-V	sufS	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
YHH3_k127_2864554_1	118166.JH976537_gene3098	4.006e-07	56.0	COG0601@1|root,COG0601@2|Bacteria,1G23K@1117|Cyanobacteria,1H80N@1150|Oscillatoriales	1117|Cyanobacteria	P	'ABC-type dipeptide oligopeptide nickel transport	-	-	2.4.2.7	ko:K00759,ko:K02033	ko00230,ko01100,ko02024,map00230,map01100,map02024	M00239	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko04147	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_2864554_0	580340.Tlie_0350	7.356e-64	238.0	COG1173@1|root,COG1173@2|Bacteria,3T9XU@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_2871849_2	696369.KI912183_gene1133	1.912e-69	255.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_4,Fer4_7,Pyr_redox_2
YHH3_k127_2871849_0	351160.LRC437	1.436e-75	269.0	COG1148@1|root,arCOG02236@2157|Archaea,2XV85@28890|Euryarchaeota,2NABC@224756|Methanomicrobia	224756|Methanomicrobia	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3	ko:K22480	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
YHH3_k127_2871849_3	243232.MJ_0863	9.04e-69	243.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
YHH3_k127_2871849_6	706587.Desti_0171	1.423e-32	134.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
YHH3_k127_2871849_4	1365176.N186_04465	7.571e-48	190.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
YHH3_k127_2871849_9	69014.TK0582	1.662e-31	133.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2434V@183968|Thermococci	28890|Euryarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
YHH3_k127_2871849_7	397948.Cmaq_1377	4.641e-32	134.0	COG0592@1|root,arCOG00488@2157|Archaea,2XQCF@28889|Crenarchaeota	28889|Crenarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
YHH3_k127_2871849_10	1343739.PAP_03275	1.722e-30	123.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
YHH3_k127_2871849_11	523850.TON_0381	2.336e-13	75.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
YHH3_k127_2871849_12	634498.mru_0169	5.472e-09	61.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
YHH3_k127_2871849_8	453591.Igni_0577	6.412e-32	134.0	COG1096@1|root,arCOG00676@2157|Archaea,2XQRA@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,S1
YHH3_k127_2871849_5	1041930.Mtc_1738	1.013e-39	155.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,2N9NN@224756|Methanomicrobia	224756|Methanomicrobia	Q	methyltransferase small	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
YHH3_k127_2871849_1	523850.TON_1644	3.975e-71	249.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
YHH3_k127_287314_0	909663.KI867150_gene284	2.827e-162	523.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MQ89@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
YHH3_k127_287314_1	1089553.Tph_c19580	1.713e-12	70.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
YHH3_k127_2876003_0	1183377.Py04_1359	1.614e-81	283.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
YHH3_k127_2876003_4	644281.MFS40622_1531	1.559e-31	131.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23QUR@183939|Methanococci	183939|Methanococci	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
YHH3_k127_2876003_7	1265313.HRUBRA_00940	4.721e-08	63.0	COG0517@1|root,COG0517@2|Bacteria,1QTZR@1224|Proteobacteria,1S7SY@1236|Gammaproteobacteria,1J6TV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
YHH3_k127_2876003_1	314230.DSM3645_12666	7.389e-72	259.0	COG0044@1|root,COG0044@2|Bacteria,2IWWW@203682|Planctomycetes	203682|Planctomycetes	F	dihydroorotase	-	-	3.5.2.2,3.5.2.3,3.5.2.5	ko:K01464,ko:K01465,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00051,M00546	R01993,R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
YHH3_k127_2876003_3	1343739.PAP_06535	2.194e-60	214.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
YHH3_k127_2876003_2	1220534.B655_0469	6.227e-67	237.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
YHH3_k127_2876003_5	1122927.KB895415_gene4375	3.172e-27	115.0	COG0454@1|root,COG0456@2|Bacteria,1VFVQ@1239|Firmicutes,4HK5T@91061|Bacilli,26YRH@186822|Paenibacillaceae	91061|Bacilli	K	Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
YHH3_k127_2876003_8	504487.JCM19302_74	0.0004734	47.0	COG3118@1|root,COG3118@2|Bacteria,4NS6N@976|Bacteroidetes,1I3YR@117743|Flavobacteriia	976|Bacteroidetes	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
YHH3_k127_2876003_6	1196322.A370_03206	3.619e-12	73.0	COG3576@1|root,COG3576@2|Bacteria,1VNIA@1239|Firmicutes,24HGG@186801|Clostridia,36RS6@31979|Clostridiaceae	186801|Clostridia	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
YHH3_k127_2892741_3	1499967.BAYZ01000050_gene2790	1.781e-15	79.0	2ABIE@1|root,310ZN@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
YHH3_k127_2892741_0	521045.Kole_0516	1.083e-33	134.0	2E86F@1|root,332JU@2|Bacteria,2GE79@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2892741_5	221288.JH992901_gene4615	0.0001492	49.0	2DKXX@1|root,30TW4@2|Bacteria,1G65F@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2892741_2	5911.EAS01029	2.867e-22	107.0	COG0457@1|root,COG0639@1|root,COG3914@1|root,KOG0376@2759|Eukaryota,KOG1126@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
YHH3_k127_2892741_1	379066.GAU_2982	5.785e-25	121.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
YHH3_k127_2892741_4	1111732.AZOD01000026_gene676	4.385e-10	67.0	COG2345@1|root,COG2345@2|Bacteria,1RIDX@1224|Proteobacteria,1S2RS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
YHH3_k127_2894808_1	509191.AEDB02000002_gene1244	1.134e-27	122.0	COG0454@1|root,COG0456@2|Bacteria,1UHRF@1239|Firmicutes,25F21@186801|Clostridia	186801|Clostridia	K	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
YHH3_k127_2894808_0	1009370.ALO_02421	6.632e-37	141.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H34D@909932|Negativicutes	909932|Negativicutes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
YHH3_k127_2917312_1	357809.Cphy_1688	1.293e-21	104.0	COG4447@1|root,COG4447@2|Bacteria,1UU3Y@1239|Firmicutes,24C6F@186801|Clostridia	186801|Clostridia	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2917312_0	593117.TGAM_1737	1.187e-96	328.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,242X6@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
YHH3_k127_2925298_3	1157490.EL26_05620	1.22e-10	74.0	2ACIQ@1|root,3124W@2|Bacteria,1V104@1239|Firmicutes,4HFYB@91061|Bacilli,277Z3@186823|Alicyclobacillaceae	91061|Bacilli	S	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
YHH3_k127_2925298_2	439481.Aboo_0188	1.793e-46	183.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,3F2I9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
YHH3_k127_2925298_0	264732.Moth_1918	8.577e-216	683.0	COG1061@1|root,COG1061@2|Bacteria,1TPDM@1239|Firmicutes,24CK8@186801|Clostridia	186801|Clostridia	KL	Helicase conserved C-terminal domain	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
YHH3_k127_2925298_1	694429.Pyrfu_0637	5.765e-52	201.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRIJ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_2942984_1	1254432.SCE1572_25520	3.206e-17	96.0	28JTH@1|root,2Z9IS@2|Bacteria,1N22P@1224|Proteobacteria,42YBU@68525|delta/epsilon subdivisions,2WTWU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_2942984_0	1502850.FG91_03701	4.013e-71	249.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2U23T@28211|Alphaproteobacteria,2K01Z@204457|Sphingomonadales	204457|Sphingomonadales	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
YHH3_k127_2947151_1	688269.Theth_1826	5.268e-72	251.0	COG0674@1|root,COG0674@2|Bacteria,2GC9T@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
YHH3_k127_2947151_0	1184251.TCELL_1237	8.475e-102	340.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
YHH3_k127_2967286_1	1459636.NTE_02750	2.595e-13	70.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
YHH3_k127_2967286_2	877455.Metbo_2396	5.33e-08	54.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,23NRZ@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
YHH3_k127_2967286_0	1268072.PSAB_01630	1.017e-41	166.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli,26RN9@186822|Paenibacillaceae	91061|Bacilli	V	Bacitracin ABC transporter ATP-binding protein	bcrA1	-	-	ko:K20459	ko02010,map02010	M00813	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.124.3,3.A.1.124.4,3.A.1.124.5	-	-	ABC_tran
YHH3_k127_2977124_1	1121286.AUMT01000010_gene3960	3.002e-23	111.0	COG0318@1|root,COG0318@2|Bacteria,4NDYR@976|Bacteroidetes,1HXTW@117743|Flavobacteriia,3ZQX1@59732|Chryseobacterium	976|Bacteroidetes	IQ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
YHH3_k127_2977124_0	673860.AciM339_0619	1.733e-45	179.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,3F2HE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,Rad51
YHH3_k127_2978941_1	1123288.SOV_5c00220	0.0003709	52.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,4H1VG@909932|Negativicutes	909932|Negativicutes	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
YHH3_k127_2978941_0	370438.PTH_1227	1.585e-16	80.0	COG3360@1|root,COG3360@2|Bacteria,1VF2X@1239|Firmicutes,24QS4@186801|Clostridia,262VS@186807|Peptococcaceae	186801|Clostridia	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
YHH3_k127_3008798_2	315730.BcerKBAB4_0153	4.124e-06	58.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,1ZB2Q@1386|Bacillus	91061|Bacilli	EU	peptidase	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
YHH3_k127_3008798_1	866536.Belba_2229	2.355e-06	56.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,47PIA@768503|Cytophagia	976|Bacteroidetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
YHH3_k127_3008798_3	1288484.APCS01000065_gene639	6.736e-06	51.0	COG1522@1|root,COG1522@2|Bacteria,1WKF0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
YHH3_k127_3008798_0	374847.Kcr_0873	4.904e-132	444.0	COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
YHH3_k127_3023978_0	926550.CLDAP_07830	1.164e-54	210.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
YHH3_k127_3024541_0	593750.Metfor_2398	1.121e-68	251.0	COG0642@1|root,arCOG02348@1|root,arCOG02385@1|root,arCOG02348@2157|Archaea,arCOG02385@2157|Archaea,arCOG06193@2157|Archaea,arCOG06219@2157|Archaea,2Y7TZ@28890|Euryarchaeota,2NAUN@224756|Methanomicrobia	2157|Archaea	T	PFAM response regulator receiver	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA_7TM,PAS,PAS_4,PAS_8,PAS_9,Response_reg
YHH3_k127_3025931_1	926550.CLDAP_35830	1.162e-99	338.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
YHH3_k127_3025931_0	224325.AF_0340	5.381e-140	465.0	COG2414@1|root,arCOG00706@2157|Archaea,2XWCH@28890|Euryarchaeota,245R8@183980|Archaeoglobi	183980|Archaeoglobi	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_3028207_0	1123239.KB898627_gene3481	1.636e-37	157.0	COG0657@1|root,COG0657@2|Bacteria,1UYX6@1239|Firmicutes,4HEMG@91061|Bacilli	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
YHH3_k127_304419_0	1150474.JQJI01000020_gene1571	1.24e-88	302.0	COG0601@1|root,COG0601@2|Bacteria,2GBYF@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_304419_1	1499967.BAYZ01000130_gene2587	6.523e-78	276.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
YHH3_k127_3048087_1	1041930.Mtc_0474	2.126e-29	129.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
YHH3_k127_3048087_3	186497.PF1458	6.738e-08	65.0	COG0524@1|root,arCOG00014@2157|Archaea,2XTW5@28890|Euryarchaeota,243Q1@183968|Thermococci	183968|Thermococci	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
YHH3_k127_3048087_0	1163730.FFONT_0035	4.013e-71	249.0	COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
YHH3_k127_3048087_5	1343739.PAP_07610	0.0002909	51.0	COG1585@1|root,arCOG01913@2157|Archaea,2Y48E@28890|Euryarchaeota,244JH@183968|Thermococci	183968|Thermococci	O	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
YHH3_k127_3048087_2	391587.KAOT1_22246	3.411e-12	76.0	COG1266@1|root,COG1266@2|Bacteria,4NHRW@976|Bacteroidetes,1I1CE@117743|Flavobacteriia	976|Bacteroidetes	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
YHH3_k127_3048087_4	1214065.BAGV01000046_gene1995	8.84e-05	52.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,1RQPC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
YHH3_k127_3080224_0	399550.Smar_0078	7.15e-06	56.0	COG2810@1|root,arCOG05724@2157|Archaea	2157|Archaea	V	restriction endonuclease	-	-	-	ko:K07504	-	-	-	-	ko00000	-	-	-	HSDR_N,HSDR_N_2
YHH3_k127_3092879_1	251221.35214774	1.053e-27	121.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
YHH3_k127_3092879_0	1122604.JONR01000011_gene3616	4.163e-55	198.0	COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,1SXRF@1236|Gammaproteobacteria,1XAGK@135614|Xanthomonadales	1224|Proteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH3_k127_309349_1	351160.LRC377	5.199e-68	254.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_309349_0	2423.NA23_0201400	1.095e-92	318.0	COG0426@1|root,COG0426@2|Bacteria,2GCAS@200918|Thermotogae	200918|Thermotogae	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
YHH3_k127_3109555_2	662479.C440_13514	1.542e-33	141.0	COG0477@1|root,arCOG00130@2157|Archaea,2XSTP@28890|Euryarchaeota,23SQI@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_3109555_1	747.DR93_194	5.995e-72	265.0	COG1073@1|root,COG1073@2|Bacteria,1N8YB@1224|Proteobacteria,1S74C@1236|Gammaproteobacteria,1Y7QS@135625|Pasteurellales	135625|Pasteurellales	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
YHH3_k127_3109555_3	1046714.AMRX01000006_gene3264	1.395e-31	134.0	2DRCH@1|root,33B7I@2|Bacteria,1NN9U@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3109555_4	523845.AQXV01000030_gene1315	1.117e-20	100.0	COG1526@1|root,arCOG04358@2157|Archaea,2XY65@28890|Euryarchaeota,23QVK@183939|Methanococci	183939|Methanococci	C	TIGRFAM formate dehydrogenase family accessory protein FdhD	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
YHH3_k127_3109555_0	358823.DF19_18600	1.057e-81	282.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
YHH3_k127_3109555_5	748449.Halha_0467	0.000285	48.0	COG1600@1|root,COG1600@2|Bacteria,1US4F@1239|Firmicutes,25A30@186801|Clostridia,3WC40@53433|Halanaerobiales	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3109698_0	1384049.CD29_17975	2.695e-88	299.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,4HVSH@91061|Bacilli,3IWHI@400634|Lysinibacillus	91061|Bacilli	S	ABC transporter, ATP-binding protein	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
YHH3_k127_3109698_1	1499967.BAYZ01000069_gene1850	1.327e-72	261.0	COG4603@1|root,COG4603@2|Bacteria	2|Bacteria	L	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
YHH3_k127_3159664_1	1262449.CP6013_0353	1.697e-88	301.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	hydA_1	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1,Urease_alpha
YHH3_k127_3159664_0	1396141.BATP01000059_gene2564	2.459e-126	410.0	COG0388@1|root,COG0388@2|Bacteria,46S7B@74201|Verrucomicrobia,2ITNA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
YHH3_k127_3159664_2	926550.CLDAP_00250	4.525e-82	281.0	COG0160@1|root,COG0160@2|Bacteria	2|Bacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
YHH3_k127_3171892_0	1121090.KB894697_gene2004	5.237e-73	259.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,1ZEB6@1386|Bacillus	91061|Bacilli	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
YHH3_k127_3210975_0	56107.Cylst_0737	3.523e-53	193.0	COG0675@1|root,COG0675@2|Bacteria,1G2YM@1117|Cyanobacteria,1HJU5@1161|Nostocales	1117|Cyanobacteria	L	Transposase, IS605 OrfB	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,MerR_1,OrfB_IS605,OrfB_Zn_ribbon,Resolvase
YHH3_k127_3210975_1	1089553.Tph_c09570	1.094e-25	116.0	COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,24DU6@186801|Clostridia,42G65@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM alpha beta hydrolase	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
YHH3_k127_3210975_2	391009.Tmel_0376	6.424e-05	50.0	COG0436@1|root,COG0436@2|Bacteria,2GC4G@200918|Thermotogae	200918|Thermotogae	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	iLJ478.TM1255	Aminotran_1_2
YHH3_k127_3210975_3	1230457.C476_05347	0.0009261	51.0	COG0642@1|root,arCOG02358@2157|Archaea,2Y7UI@28890|Euryarchaeota,240X6@183963|Halobacteria	183963|Halobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
YHH3_k127_3238029_1	273075.Ta0514	2e-33	140.0	COG0095@1|root,arCOG01939@2157|Archaea,2XUJ0@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0095 Lipoate-protein ligase A	lpl	GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
YHH3_k127_3238029_2	760568.Desku_0323	9.109e-20	93.0	COG0599@1|root,COG0599@2|Bacteria,1VFY0@1239|Firmicutes,25CIE@186801|Clostridia,2631D@186807|Peptococcaceae	186801|Clostridia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
YHH3_k127_3238029_0	1499967.BAYZ01000147_gene686	7.448e-75	264.0	COG1063@1|root,COG1063@2|Bacteria,2NQVE@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	ydjL	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_3238029_3	178306.PAE3643	2.064e-07	62.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2XSKE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Zinc finger TFIIB-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
YHH3_k127_3273987_0	401526.TcarDRAFT_1837	1.665e-85	290.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H2QE@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
YHH3_k127_3273987_1	484770.UFO1_3311	2.876e-70	248.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4H27J@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
YHH3_k127_327567_0	926569.ANT_18640	4.635e-145	473.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
YHH3_k127_327567_1	768670.Calni_0847	9.853e-42	161.0	COG2319@1|root,COG4249@1|root,COG2319@2|Bacteria,COG4249@2|Bacteria,2GG9I@200930|Deferribacteres	200930|Deferribacteres	G	peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
YHH3_k127_3278865_0	1519439.JPJG01000018_gene283	5.928e-99	328.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,2N6NP@216572|Oscillospiraceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
YHH3_k127_3278865_3	696281.Desru_1676	1.415e-53	200.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,2611K@186807|Peptococcaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
YHH3_k127_3278865_2	868131.MSWAN_1917	1.013e-54	205.0	COG0573@1|root,arCOG00167@2157|Archaea,2XTYD@28890|Euryarchaeota,23NUX@183925|Methanobacteria	183925|Methanobacteria	P	phosphate transport system	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
YHH3_k127_3278865_5	583355.Caka_2255	3.882e-15	87.0	COG0226@1|root,COG0226@2|Bacteria,46SP0@74201|Verrucomicrobia,3K734@414999|Opitutae	414999|Opitutae	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
YHH3_k127_3278865_4	395965.Msil_2649	3.84e-17	93.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2TTJA@28211|Alphaproteobacteria,3NC6V@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	PBP superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	PBP_like_2
YHH3_k127_3278865_6	330779.Saci_1600	1.285e-12	79.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
YHH3_k127_3278865_1	342451.SSP0028	5.032e-72	252.0	COG0863@1|root,COG0863@2|Bacteria,1VC9K@1239|Firmicutes,4HSVW@91061|Bacilli	91061|Bacilli	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
YHH3_k127_3278865_7	660470.Theba_0404	4.499e-12	72.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
YHH3_k127_3380700_3	926569.ANT_27180	2.183e-08	67.0	COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
YHH3_k127_3380700_1	324602.Caur_2628	7.394e-24	106.0	COG0412@1|root,COG0412@2|Bacteria,2G8NW@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
YHH3_k127_3380700_2	324602.Caur_2628	8.23e-12	67.0	COG0412@1|root,COG0412@2|Bacteria,2G8NW@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
YHH3_k127_3380700_0	1134413.ANNK01000103_gene885	1.446e-98	324.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,4HB82@91061|Bacilli,1ZDT7@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
YHH3_k127_3414062_0	269797.Mbar_A2941	1.875e-12	77.0	COG0457@1|root,arCOG06750@1|root,arCOG03032@2157|Archaea,arCOG06750@2157|Archaea,2Y7M7@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
YHH3_k127_3419_0	1449050.JNLE01000003_gene200	8.849e-11	63.0	29QV6@1|root,30BVB@2|Bacteria,1U8PC@1239|Firmicutes,252MJ@186801|Clostridia,36SRQ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3448785_0	1448860.BBJO01000016_gene2276	1.671e-19	92.0	COG2309@1|root,arCOG01888@2157|Archaea,2XSUA@28890|Euryarchaeota,23TKX@183963|Halobacteria	183963|Halobacteria	E	Leucyl aminopeptidase (Aminopeptidase T)	pepB3	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
YHH3_k127_3448785_1	296587.XP_002499612.1	1.038e-08	62.0	COG1055@1|root,KOG2639@2759|Eukaryota,37JD9@33090|Viridiplantae,34NC8@3041|Chlorophyta	3041|Chlorophyta	P	Arsenical pump membrane protein	ARSB	-	-	-	-	-	-	-	-	-	-	-	ArsB,CitMHS
YHH3_k127_3469250_0	457570.Nther_1921	4.395e-97	339.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
YHH3_k127_3469250_2	1395587.P364_0102870	6.051e-44	185.0	COG0454@1|root,COG0456@2|Bacteria,1TQQA@1239|Firmicutes,4HBXN@91061|Bacilli,26RQ4@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
YHH3_k127_3469250_1	1089552.KI911559_gene541	9.801e-45	169.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,2JRV2@204441|Rhodospirillales	204441|Rhodospirillales	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
YHH3_k127_3475362_0	368407.Memar_1426	5.372e-62	220.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
YHH3_k127_3475362_1	429009.Adeg_0280	4.112e-22	98.0	COG2442@1|root,COG2442@2|Bacteria,1VYG9@1239|Firmicutes,252G4@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
YHH3_k127_3475362_2	522306.CAP2UW1_4416	3.708e-21	96.0	COG4634@1|root,COG4634@2|Bacteria,1NHCH@1224|Proteobacteria,2W5NJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3508010_0	227377.CBU_1769	6.753e-21	100.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,1S802@1236|Gammaproteobacteria,1JDJN@118969|Legionellales	118969|Legionellales	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
YHH3_k127_3523915_0	397948.Cmaq_1197	1.306e-177	572.0	COG0060@1|root,arCOG00807@2157|Archaea,2XPWM@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
YHH3_k127_3523915_1	1394178.AWOO02000054_gene7978	1.093e-18	89.0	COG4997@1|root,COG4997@2|Bacteria	2|Bacteria	I	bis(5'-adenosyl)-triphosphatase activity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	PRA-PH
YHH3_k127_3537484_0	351160.LRC378	3.052e-88	301.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota,2NAQG@224756|Methanomicrobia	224756|Methanomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_3537484_1	1121441.AUCX01000016_gene2365	5.258e-65	227.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2M9B4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
YHH3_k127_354639_0	945712.CULC22_00206	3.364e-05	50.0	COG0778@1|root,COG0778@2|Bacteria,2I65Z@201174|Actinobacteria,22KVB@1653|Corynebacteriaceae	201174|Actinobacteria	C	nitroreductase	mdaA	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH3_k127_3569200_2	332101.JIBU02000025_gene3218	3.364e-06	53.0	28Q1F@1|root,2ZCJT@2|Bacteria,1VI7R@1239|Firmicutes,24D4W@186801|Clostridia,36EXU@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3569200_1	644281.MFS40622_0489	9.772e-20	97.0	COG4032@1|root,arCOG01614@2157|Archaea,2XVNH@28890|Euryarchaeota,23QVW@183939|Methanococci	183939|Methanococci	G	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019295,GO:0019296,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0048037,GO:0050545,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:1901363,GO:1901576,GO:1901681	4.1.1.79	ko:K13039	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
YHH3_k127_3569200_0	1229205.BUPH_05877	2.564e-29	123.0	COG0028@1|root,COG4032@1|root,COG0028@2|Bacteria,COG4032@2|Bacteria,1R6QP@1224|Proteobacteria,2VNIS@28216|Betaproteobacteria,1K11W@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	phosphonopyruvate decarboxylase	ppd	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
YHH3_k127_3569200_3	55529.EKX39835	4.522e-05	57.0	KOG1777@1|root,KOG1777@2759|Eukaryota	2759|Eukaryota	G	protein ubiquitination	FBXO11	GO:0000003,GO:0000151,GO:0000209,GO:0001667,GO:0002119,GO:0002164,GO:0003006,GO:0003008,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006325,GO:0006342,GO:0006355,GO:0006464,GO:0006479,GO:0006508,GO:0006511,GO:0006807,GO:0006928,GO:0006996,GO:0007275,GO:0007548,GO:0007600,GO:0007605,GO:0008078,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008406,GO:0008757,GO:0009056,GO:0009057,GO:0009790,GO:0009791,GO:0009792,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010498,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010941,GO:0010942,GO:0016043,GO:0016273,GO:0016274,GO:0016458,GO:0016477,GO:0016567,GO:0016740,GO:0016741,GO:0018193,GO:0018195,GO:0018216,GO:0018996,GO:0019005,GO:0019219,GO:0019222,GO:0019538,GO:0019787,GO:0019941,GO:0022414,GO:0022607,GO:0022613,GO:0022618,GO:0030163,GO:0031047,GO:0031048,GO:0031146,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031461,GO:0031974,GO:0031981,GO:0032259,GO:0032446,GO:0032501,GO:0032502,GO:0032991,GO:0034622,GO:0035246,GO:0036211,GO:0040011,GO:0040029,GO:0040034,GO:0042303,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0043632,GO:0043687,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045137,GO:0045814,GO:0045892,GO:0045934,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048608,GO:0048731,GO:0048856,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050877,GO:0050954,GO:0051171,GO:0051172,GO:0051179,GO:0051252,GO:0051253,GO:0051276,GO:0051603,GO:0051674,GO:0060255,GO:0060966,GO:0060968,GO:0061458,GO:0065003,GO:0065007,GO:0070013,GO:0070647,GO:0070922,GO:0070923,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1902679,GO:1903506,GO:1903507,GO:1990234,GO:2000112,GO:2000113,GO:2001141	-	ko:K10297	-	-	-	-	ko00000,ko04121	-	-	-	Beta_helix,F-box-like,NosD,zf-UBR
YHH3_k127_357544_8	272557.APE_0358	1.611e-26	114.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
YHH3_k127_357544_1	591019.Shell_1432	1.827e-70	246.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
YHH3_k127_357544_2	391623.TERMP_00105	1.417e-57	205.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,242J0@183968|Thermococci	183968|Thermococci	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
YHH3_k127_357544_10	368408.Tpen_0241	1.134e-14	74.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
YHH3_k127_357544_3	342949.PNA2_0366	2.019e-53	190.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
YHH3_k127_357544_5	351160.RCIX2562	5.414e-44	166.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,2N9KP@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
YHH3_k127_357544_9	1121945.ATXS01000002_gene611	5.645e-24	112.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,23SSD@183963|Halobacteria	183963|Halobacteria	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
YHH3_k127_357544_6	243232.MJ_0473	1.113e-36	143.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23QT2@183939|Methanococci	183939|Methanococci	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
YHH3_k127_357544_4	374847.Kcr_1569	3.201e-45	173.0	COG0256@1|root,arCOG04088@2157|Archaea	2157|Archaea	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
YHH3_k127_357544_0	633148.Tagg_0867	4.827e-71	246.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
YHH3_k127_357544_7	224719.Abm4_1255	1.942e-35	140.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,23P1Y@183925|Methanobacteria	183925|Methanobacteria	J	ribosomal protein	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
YHH3_k127_357544_11	490899.DKAM_0840	1.196e-07	57.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
YHH3_k127_3591689_1	1532557.JL37_28895	1.094e-10	70.0	COG5316@1|root,COG5316@2|Bacteria,1N0IJ@1224|Proteobacteria,2VMTC@28216|Betaproteobacteria,3T365@506|Alcaligenaceae	28216|Betaproteobacteria	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
YHH3_k127_3591689_0	1444309.JAQG01000017_gene755	2.195e-38	149.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,26SYE@186822|Paenibacillaceae	91061|Bacilli	E	peptidase M20	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
YHH3_k127_3622101_1	1183438.GKIL_1869	7.673e-11	72.0	COG2319@1|root,COG4249@1|root,COG2319@2|Bacteria,COG4249@2|Bacteria,1FZVW@1117|Cyanobacteria	1117|Cyanobacteria	A	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
YHH3_k127_3622101_0	635013.TherJR_1098	2.536e-32	138.0	COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,24DS0@186801|Clostridia,264JQ@186807|Peptococcaceae	186801|Clostridia	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
YHH3_k127_3637853_1	255470.cbdbA785	7.71e-80	275.0	COG1233@1|root,COG1233@2|Bacteria,2G5ZA@200795|Chloroflexi,34D93@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
YHH3_k127_3637853_2	98439.AJLL01000007_gene3903	2.286e-28	119.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HIT
YHH3_k127_3637853_0	186497.PF1497	1.086e-142	463.0	COG0436@1|root,arCOG01131@2157|Archaea,2XVXM@28890|Euryarchaeota,243JD@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
YHH3_k127_3637853_3	1120972.AUMH01000013_gene2412	9.809e-28	119.0	2EIVB@1|root,33CKP@2|Bacteria,1TTRI@1239|Firmicutes,4I1UA@91061|Bacilli	91061|Bacilli	S	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
YHH3_k127_3637853_4	90813.JQMT01000001_gene94	2.369e-07	57.0	COG2337@1|root,COG2337@2|Bacteria,1N0JV@1224|Proteobacteria,1SDFP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
YHH3_k127_3645276_0	329726.AM1_1443	1.829e-07	62.0	COG1073@1|root,COG1073@2|Bacteria,1G1MU@1117|Cyanobacteria	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
YHH3_k127_3645276_1	439481.Aboo_0134	0.000139	52.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
YHH3_k127_3653234_4	1121439.dsat_0571	0.0003852	45.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,42P51@68525|delta/epsilon subdivisions,2WK1J@28221|Deltaproteobacteria,2M7RR@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	heterodisulfide reductase	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
YHH3_k127_3653234_2	264732.Moth_0439	6.149e-20	97.0	COG1150@1|root,COG1150@2|Bacteria,1V8UM@1239|Firmicutes,24J4U@186801|Clostridia,42GMS@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
YHH3_k127_3653234_1	388399.SSE37_03590	1.62e-22	106.0	COG4912@1|root,COG4912@2|Bacteria,1NKDG@1224|Proteobacteria,2TU19@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
YHH3_k127_3653234_3	1121926.AXWO01000001_gene3667	1.702e-08	63.0	COG1695@1|root,COG1695@2|Bacteria,2IQSE@201174|Actinobacteria,4F05U@85014|Glycomycetales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
YHH3_k127_3653234_0	910964.GEAM_1039	3.517e-59	218.0	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,1RPYB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	ycaQ	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
YHH3_k127_3683899_0	765420.OSCT_0926	5.482e-20	104.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
YHH3_k127_3686903_1	351160.RRC525	4.768e-34	145.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
YHH3_k127_3686903_0	572478.Vdis_0046	1.043e-60	215.0	COG0163@1|root,arCOG01703@2157|Archaea,2XQJ7@28889|Crenarchaeota	28889|Crenarchaeota	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
YHH3_k127_3697964_0	177437.HRM2_33510	1.102e-94	327.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42Q2C@68525|delta/epsilon subdivisions,2WKNN@28221|Deltaproteobacteria,2MN1W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
YHH3_k127_3697964_3	1121422.AUMW01000010_gene1147	8.183e-31	128.0	COG1014@1|root,COG1014@2|Bacteria,1VV4V@1239|Firmicutes,25039@186801|Clostridia	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	POR
YHH3_k127_3697964_1	6239.K09A9.2.1	5.3e-34	151.0	COG1100@1|root,KOG0097@2759|Eukaryota,38EZ9@33154|Opisthokonta,3BBM7@33208|Metazoa,3CZZI@33213|Bilateria,40B9A@6231|Nematoda,1KV0X@119089|Chromadorea,40S2M@6236|Rhabditida	33208|Metazoa	U	Rab subfamily of small GTPases	RAB14	GO:0000166,GO:0000323,GO:0001775,GO:0001845,GO:0001882,GO:0001883,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005773,GO:0005783,GO:0005791,GO:0005794,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006661,GO:0006793,GO:0006796,GO:0006810,GO:0006873,GO:0006885,GO:0006887,GO:0006892,GO:0006895,GO:0006897,GO:0006909,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007033,GO:0007040,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007264,GO:0007265,GO:0007589,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008543,GO:0008610,GO:0008654,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009987,GO:0010008,GO:0010033,GO:0012505,GO:0012506,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016324,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019637,GO:0019725,GO:0022607,GO:0023052,GO:0030003,GO:0030004,GO:0030100,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030140,GO:0030141,GO:0030641,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031489,GO:0031901,GO:0031982,GO:0031984,GO:0032456,GO:0032482,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0035556,GO:0035639,GO:0036094,GO:0036230,GO:0036477,GO:0042119,GO:0042175,GO:0042221,GO:0042592,GO:0042599,GO:0042742,GO:0043025,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043277,GO:0043299,GO:0043312,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044297,GO:0044344,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045017,GO:0045055,GO:0045176,GO:0045177,GO:0045202,GO:0045321,GO:0045335,GO:0045851,GO:0045995,GO:0046474,GO:0046486,GO:0046488,GO:0046903,GO:0046907,GO:0048193,GO:0048471,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050878,GO:0050896,GO:0051049,GO:0051128,GO:0051179,GO:0051234,GO:0051239,GO:0051452,GO:0051453,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0055037,GO:0055038,GO:0055067,GO:0055080,GO:0055082,GO:0060627,GO:0065007,GO:0065008,GO:0070820,GO:0070821,GO:0070848,GO:0070887,GO:0070925,GO:0071310,GO:0071363,GO:0071495,GO:0071704,GO:0071774,GO:0071840,GO:0071944,GO:0080171,GO:0090382,GO:0090383,GO:0090386,GO:0090387,GO:0090390,GO:0090407,GO:0097159,GO:0097208,GO:0097367,GO:0097458,GO:0097708,GO:0098542,GO:0098588,GO:0098590,GO:0098657,GO:0098771,GO:0098791,GO:0098805,GO:0099503,GO:1901265,GO:1901363,GO:1901576,GO:2000026	-	ko:K07881	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_3697964_2	189426.PODO_22750	1.524e-32	132.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4HAJC@91061|Bacilli,274EQ@186822|Paenibacillaceae	91061|Bacilli	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
YHH3_k127_3698849_0	926569.ANT_23500	1.564e-72	261.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
YHH3_k127_3698849_3	345341.KUTG_04988	9.597e-06	57.0	COG1522@1|root,COG1522@2|Bacteria,2IFSQ@201174|Actinobacteria,4E4W6@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_3698849_2	666510.ASAC_0761	1.323e-19	93.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
YHH3_k127_3698849_1	1123277.KB893181_gene2301	3.941e-69	243.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.23	ko:K01054	ko00561,ko01100,ko04714,ko04723,ko04923,map00561,map01100,map04714,map04723,map04923	M00098	R01351	RC00020,RC00041	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Hydrolase_4
YHH3_k127_3701793_1	273057.SSO1877	9.947e-09	58.0	COG5466@1|root,arCOG05278@2157|Archaea	2157|Archaea	S	small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
YHH3_k127_3701793_0	1033810.HLPCO_002262	2.839e-26	118.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	ko:K06889,ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase,Malectin,Peptidase_S9
YHH3_k127_3728440_0	1041930.Mtc_0820	1.474e-55	201.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2N9FP@224756|Methanomicrobia	224756|Methanomicrobia	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
YHH3_k127_3729711_0	632292.Calhy_2553	4.166e-65	246.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853,DUF87,PLDc_2
YHH3_k127_3729711_1	526227.Mesil_2006	5.121e-22	100.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
YHH3_k127_3735200_0	269797.Mbar_A1752	1.24e-81	290.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
YHH3_k127_3746055_0	386456.JQKN01000007_gene3357	1.879e-05	54.0	COG2232@1|root,arCOG01595@2157|Archaea,2XVAH@28890|Euryarchaeota,23P2I@183925|Methanobacteria	183925|Methanobacteria	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
YHH3_k127_3746055_1	1280698.AUJS01000013_gene389	0.0007284	46.0	COG3664@1|root,COG4977@1|root,COG3664@2|Bacteria,COG4977@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia	186801|Clostridia	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,Glyco_hydro_39,HTH_18
YHH3_k127_3791087_1	1227500.C494_05260	1.626e-28	120.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,23SCV@183963|Halobacteria	183963|Halobacteria	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH3_k127_3791087_2	384616.Pisl_2001	1.61e-05	53.0	COG0640@1|root,arCOG03859@2157|Archaea,2XR12@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
YHH3_k127_3791087_0	391623.TERMP_00641	1.066e-65	230.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,243M3@183968|Thermococci	183968|Thermococci	E	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_3839343_2	574375.BAGA_09450	0.0002852	53.0	COG3420@1|root,COG3420@2|Bacteria,1UN63@1239|Firmicutes,4HAZN@91061|Bacilli,1ZE50@1386|Bacillus	91061|Bacilli	P	Periplasmic copper-binding protein (NosD)	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
YHH3_k127_3839343_0	1381751.JAJB01000060_gene242	2.75e-11	76.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4F9MQ@85019|Brevibacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_3839343_1	1122138.AQUZ01000024_gene7626	7.029e-05	55.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4DPH8@85009|Propionibacteriales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_388267_0	941824.TCEL_01558	6.203e-163	556.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
YHH3_k127_388267_1	96561.Dole_0225	1.134e-105	383.0	COG0318@1|root,COG0318@2|Bacteria,1NRF1@1224|Proteobacteria,42ZBQ@68525|delta/epsilon subdivisions,2WUGE@28221|Deltaproteobacteria,2MMKI@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
YHH3_k127_388267_2	509191.AEDB02000081_gene2489	2.085e-29	124.0	COG3708@1|root,COG3708@2|Bacteria,1V2UA@1239|Firmicutes,24GER@186801|Clostridia,3WKGA@541000|Ruminococcaceae	186801|Clostridia	K	Protein of unknown function (DUF3788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3788,DUF3795
YHH3_k127_388267_3	649638.Trad_0935	2.061e-28	126.0	28JTH@1|root,2Z9IS@2|Bacteria,1WMBE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3939670_0	357808.RoseRS_1546	1.615e-39	168.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi,3767C@32061|Chloroflexia	32061|Chloroflexia	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3951429_1	1041930.Mtc_0831	5.242e-22	99.0	COG0784@1|root,arCOG02391@2157|Archaea,2Y6EC@28890|Euryarchaeota,2NBEQ@224756|Methanomicrobia	224756|Methanomicrobia	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
YHH3_k127_3951429_2	768710.DesyoDRAFT_2944	1.499e-08	61.0	COG2201@1|root,COG2201@2|Bacteria,1VBRC@1239|Firmicutes,24J81@186801|Clostridia,265JA@186807|Peptococcaceae	186801|Clostridia	NT	cheY-homologous receiver domain	cheY2	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
YHH3_k127_3951429_0	768672.Desfe_0142	8.493e-29	125.0	COG0467@1|root,arCOG01171@2157|Archaea,2XPNC@28889|Crenarchaeota	28889|Crenarchaeota	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
YHH3_k127_3951429_3	1122605.KB893627_gene2904	1.641e-05	56.0	COG0457@1|root,COG4585@1|root,COG0457@2|Bacteria,COG4585@2|Bacteria,4NI1V@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,TPR_12,TPR_8
YHH3_k127_3954198_2	1089553.Tph_c09590	5.194e-21	96.0	2DBZQ@1|root,2ZC2Y@2|Bacteria,1V2KN@1239|Firmicutes,24G8V@186801|Clostridia,42I8U@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_3954198_1	269797.Mbar_A3370	2.329e-57	211.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,2NAHY@224756|Methanomicrobia	224756|Methanomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH3_k127_3954198_3	1042877.GQS_09300	8.739e-13	80.0	COG1668@1|root,arCOG01462@2157|Archaea,2XX4X@28890|Euryarchaeota,242TZ@183968|Thermococci	183968|Thermococci	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
YHH3_k127_3954198_0	485913.Krac_6352	1.683e-140	458.0	COG0402@1|root,COG0402@2|Bacteria,2G6DG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,CYTH
YHH3_k127_3954282_6	643473.KB235930_gene479	4.772e-06	53.0	COG0454@1|root,COG0456@2|Bacteria,1G5TG@1117|Cyanobacteria,1HMRP@1161|Nostocales	1117|Cyanobacteria	K	TIGRFAM Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
YHH3_k127_3954282_5	333138.LQ50_11730	1.602e-07	63.0	COG0454@1|root,COG0456@2|Bacteria,1V50M@1239|Firmicutes,4HH63@91061|Bacilli,1ZG7D@1386|Bacillus	91061|Bacilli	K	acetyltransferase	yqjY	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
YHH3_k127_3954282_3	2325.TKV_c00370	1.11e-65	243.0	COG1785@1|root,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,42GK7@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Alkaline phosphatase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase,Cu_amine_oxidN1
YHH3_k127_3954282_1	589924.Ferp_2326	1.022e-128	426.0	COG0145@1|root,arCOG01511@2157|Archaea,2XT1J@28890|Euryarchaeota,24788@183980|Archaeoglobi	183980|Archaeoglobi	E	Hydantoinase/oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
YHH3_k127_3954282_4	1343740.M271_01165	4.49e-19	94.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
YHH3_k127_3954282_0	868864.Dester_0096	1.788e-156	510.0	COG0146@1|root,COG0146@2|Bacteria,2G3NG@200783|Aquificae	200783|Aquificae	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
YHH3_k127_3954282_2	272844.PAB0323	1.075e-97	333.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
YHH3_k127_3965569_2	1120985.AUMI01000014_gene812	1.118e-16	90.0	COG0517@1|root,COG1208@1|root,COG0517@2|Bacteria,COG1208@2|Bacteria,1TRKP@1239|Firmicutes,4H503@909932|Negativicutes	909932|Negativicutes	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,NTP_transferase
YHH3_k127_3965569_1	864051.BurJ1DRAFT_1605	4.049e-17	83.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2VVZH@28216|Betaproteobacteria,1KMKF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	hypC1	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
YHH3_k127_3965569_0	572546.Arcpr_1852	3.505e-118	390.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,245RV@183980|Archaeoglobi	183980|Archaeoglobi	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
YHH3_k127_3965569_3	903814.ELI_2442	2.359e-08	65.0	COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,249P4@186801|Clostridia,25VGX@186806|Eubacteriaceae	186801|Clostridia	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	ygeW	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
YHH3_k127_3968035_4	1457250.BBMO01000001_gene1083	1.208e-08	60.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,23WBW@183963|Halobacteria	183963|Halobacteria	K	COG0456 Acetyltransferases	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
YHH3_k127_3968035_3	135651.CBN10214	4.825e-14	76.0	COG5133@1|root,KOG3381@2759|Eukaryota,3A1NG@33154|Opisthokonta,3BQM5@33208|Metazoa,3D4ZQ@33213|Bilateria,40DTW@6231|Nematoda,1KW7V@119089|Chromadorea,4118U@6236|Rhabditida	33208|Metazoa	S	Iron-sulfur cluster assembly protein	FAM96B	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0006790,GO:0007059,GO:0008150,GO:0008152,GO:0009987,GO:0015630,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0031974,GO:0031981,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0051186,GO:0070013,GO:0071817,GO:0071840,GO:0097361	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
YHH3_k127_3968035_0	1459636.NTE_00077	1.184e-64	234.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
YHH3_k127_3968035_2	935948.KE386495_gene1949	3.281e-19	97.0	COG1143@1|root,COG2006@1|root,COG1143@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,42F8W@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
YHH3_k127_3968035_1	589924.Ferp_2446	2.157e-28	119.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,246NU@183980|Archaeoglobi	183980|Archaeoglobi	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
YHH3_k127_3975879_0	1041504.RATSFB_0350	1.512e-05	55.0	COG2234@1|root,COG2234@2|Bacteria,1UHWN@1239|Firmicutes,25E5J@186801|Clostridia,36N7C@31979|Clostridiaceae	186801|Clostridia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
YHH3_k127_4017844_0	673860.AciM339_0333	1.539e-114	377.0	COG0451@1|root,arCOG04468@2157|Archaea,2XT9R@28890|Euryarchaeota,3F346@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
YHH3_k127_4017844_1	234267.Acid_6515	2.197e-35	145.0	COG1404@1|root,COG3386@1|root,COG1404@2|Bacteria,COG3386@2|Bacteria,3Y2EZ@57723|Acidobacteria	2|Bacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	ASH,DUF11,DUF4347,DUF5122,He_PIG,SBBP
YHH3_k127_4022610_1	338966.Ppro_3011	3.96e-20	92.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,43CDX@68525|delta/epsilon subdivisions,2X7PU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
YHH3_k127_4022610_0	1123368.AUIS01000003_gene1707	3.979e-104	363.0	COG2202@1|root,COG3614@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3614@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria,2NDJ6@225057|Acidithiobacillales	1236|Gammaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd
YHH3_k127_4052007_3	5722.XP_001305092.1	0.0001913	53.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	-	-	-	ko:K07874,ko:K07901	ko04144,ko04152,ko04530,ko04972,ko05134,map04144,map04152,map04530,map04972,map05134	-	-	-	ko00000,ko00001,ko03036,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_4052007_2	929556.Solca_1219	2.271e-36	143.0	COG1611@1|root,COG1611@2|Bacteria,4P7JF@976|Bacteroidetes,1IZUP@117747|Sphingobacteriia	976|Bacteroidetes	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
YHH3_k127_4052007_1	4565.Traes_4AL_2EBB63DBA.2	3.786e-39	156.0	COG0639@1|root,KOG0374@2759|Eukaryota,37IYN@33090|Viridiplantae,3G8UW@35493|Streptophyta,3KXP5@4447|Liliopsida,3INWE@38820|Poales	35493|Streptophyta	T	Serine threonine-protein phosphatase	-	-	3.1.3.16	ko:K06269	ko03015,ko04022,ko04024,ko04113,ko04114,ko04218,ko04261,ko04270,ko04390,ko04510,ko04611,ko04720,ko04728,ko04750,ko04810,ko04910,ko04921,ko04931,ko05031,ko05034,ko05168,ko05205,map03015,map04022,map04024,map04113,map04114,map04218,map04261,map04270,map04390,map04510,map04611,map04720,map04728,map04750,map04810,map04910,map04921,map04931,map05031,map05034,map05168,map05205	-	-	-	ko00000,ko00001,ko01000,ko01009,ko03019,ko03021,ko03041	-	-	-	Metallophos,STPPase_N
YHH3_k127_4052007_0	269797.Mbar_A1412	6.748e-82	282.0	COG2006@1|root,arCOG02447@2157|Archaea,2Y2ES@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
YHH3_k127_4069341_2	1210908.HSB1_18280	7.392e-48	176.0	COG2309@1|root,arCOG01888@2157|Archaea,2XSUA@28890|Euryarchaeota,23TKX@183963|Halobacteria	183963|Halobacteria	E	Leucyl aminopeptidase (Aminopeptidase T)	pepB3	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
YHH3_k127_4069341_3	1184607.AUCHE_05_00210	3.171e-10	72.0	COG0642@1|root,COG2205@2|Bacteria,2INHI@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
YHH3_k127_4069341_1	439235.Dalk_5102	6.029e-51	196.0	COG2203@1|root,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria	1224|Proteobacteria	T	GAF domain	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS,PAS_10,PAS_9,Response_reg,dCache_1
YHH3_k127_4069341_0	1211035.CD30_16035	3.889e-59	211.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,4HBV3@91061|Bacilli	91061|Bacilli	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
YHH3_k127_4090027_3	675815.VOA_002063	1.686e-08	64.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XT9F@135623|Vibrionales	135623|Vibrionales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
YHH3_k127_4090027_0	1122138.AQUZ01000036_gene5471	6.17e-37	158.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4DU0R@85009|Propionibacteriales	201174|Actinobacteria	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH3_k127_4090027_1	103733.JNYO01000043_gene5872	1.702e-36	162.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DXRX@85010|Pseudonocardiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
YHH3_k127_4090027_2	796942.HMPREF9623_00449	3.791e-36	150.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA2	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
YHH3_k127_4093467_0	420247.Msm_0046	5.823e-57	215.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,23NSB@183925|Methanobacteria	183925|Methanobacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	nox	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Pyr_redox_dim
YHH3_k127_4111114_0	506534.Rhein_1876	6.367e-71	262.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,1WXBE@135613|Chromatiales	135613|Chromatiales	P	PFAM Sodium sulphate symporter	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
YHH3_k127_4111114_1	1122129.AUEF01000011_gene1285	7.755e-09	65.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,4GXX1@90964|Staphylococcaceae	91061|Bacilli	EGP	Quinolone resistance protein norA	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
YHH3_k127_4132948_0	1125863.JAFN01000001_gene2044	8.732e-112	375.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
YHH3_k127_4132948_1	589924.Ferp_1018	9.703e-24	103.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
YHH3_k127_413638_0	1313265.JNIE01000005_gene269	3.993e-07	60.0	COG0457@1|root,COG0457@2|Bacteria,2G407@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
YHH3_k127_4147960_0	316274.Haur_0876	6.779e-12	67.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,Polyketide_cyc2
YHH3_k127_4147960_3	1110697.NCAST_20_00750	9.24e-05	48.0	COG3832@1|root,COG3832@2|Bacteria,2ISCU@201174|Actinobacteria,4G1QF@85025|Nocardiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
YHH3_k127_4147960_2	663610.JQKO01000017_gene1679	1.588e-06	60.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,3NBEA@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	DJ-1/PfpI family	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
YHH3_k127_4147960_1	1268072.PSAB_20100	2.365e-09	59.0	COG4188@1|root,COG4188@2|Bacteria,1V2UM@1239|Firmicutes,4HMSG@91061|Bacilli,276SY@186822|Paenibacillaceae	91061|Bacilli	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
YHH3_k127_4164310_4	374847.Kcr_0417	8.827e-08	63.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
YHH3_k127_4164310_1	523850.TON_0586	7.425e-85	289.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2436C@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit beta	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
YHH3_k127_4164310_2	1220534.B655_0443	2.121e-40	155.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
YHH3_k127_4164310_6	638303.Thal_1379	8.087e-05	49.0	COG1977@1|root,COG1977@2|Bacteria,2G563@200783|Aquificae	200783|Aquificae	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
YHH3_k127_4164310_5	697303.Thewi_2684	7.691e-07	62.0	COG0738@1|root,COG0738@2|Bacteria,1UJ6C@1239|Firmicutes,2494T@186801|Clostridia	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	ko:K18214	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.6	-	-	MFS_1
YHH3_k127_4164310_0	1094980.Mpsy_3012	1.531e-90	308.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2N98S@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
YHH3_k127_4164310_3	121225.PHUM414350-PA	4.419e-09	66.0	COG4886@1|root,KOG0619@2759|Eukaryota,39VVV@33154|Opisthokonta,3BM8Y@33208|Metazoa,3D3BK@33213|Bilateria,41XY0@6656|Arthropoda,3SH6X@50557|Insecta,3ECGP@33342|Paraneoptera	33208|Metazoa	S	Leucine rich repeat C-terminal domain	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005912,GO:0005924,GO:0005927,GO:0006928,GO:0006935,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0009605,GO:0009987,GO:0014812,GO:0016020,GO:0016021,GO:0016477,GO:0023052,GO:0030054,GO:0030055,GO:0030334,GO:0030336,GO:0031224,GO:0032101,GO:0032102,GO:0032879,GO:0032991,GO:0035385,GO:0036061,GO:0040011,GO:0040012,GO:0040013,GO:0042221,GO:0042330,GO:0044425,GO:0044464,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048870,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0050922,GO:0051179,GO:0051270,GO:0051271,GO:0051674,GO:0051716,GO:0060326,GO:0065007,GO:0070161,GO:0070887,GO:0071944,GO:2000145,GO:2000146,GO:2001281,GO:2001282,GO:2001283	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	LRR_8,Lys
YHH3_k127_417435_2	379066.GAU_2113	1.532e-61	219.0	COG4181@1|root,COG4181@2|Bacteria,1ZUJS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_417435_4	399550.Smar_0879	6.151e-14	72.0	COG3609@1|root,arCOG01009@2157|Archaea,2XR62@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
YHH3_k127_417435_3	45351.EDO47471	1.526e-35	141.0	KOG0078@1|root,KOG0078@2759|Eukaryota,38EHU@33154|Opisthokonta,3B9UK@33208|Metazoa	33208|Metazoa	U	RAB10, member RAS oncogene family	RAB10	GO:0000166,GO:0000902,GO:0000904,GO:0001738,GO:0001775,GO:0001882,GO:0001883,GO:0002009,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002790,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005929,GO:0006810,GO:0006886,GO:0006887,GO:0006892,GO:0006893,GO:0006904,GO:0006955,GO:0006996,GO:0007029,GO:0007163,GO:0007275,GO:0007399,GO:0007405,GO:0007409,GO:0008092,GO:0008104,GO:0008150,GO:0008283,GO:0008356,GO:0009306,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0010033,GO:0010243,GO:0010256,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0017145,GO:0017157,GO:0019001,GO:0019003,GO:0019882,GO:0022008,GO:0022406,GO:0030010,GO:0030030,GO:0030133,GO:0030141,GO:0030154,GO:0030182,GO:0030659,GO:0030667,GO:0030855,GO:0030859,GO:0031090,GO:0031175,GO:0031410,GO:0031489,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032593,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032940,GO:0032989,GO:0032990,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0036230,GO:0036445,GO:0042119,GO:0042175,GO:0042221,GO:0042886,GO:0042995,GO:0043001,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0043434,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045165,GO:0045184,GO:0045196,GO:0045200,GO:0045321,GO:0046677,GO:0046903,GO:0046907,GO:0048103,GO:0048193,GO:0048278,GO:0048468,GO:0048471,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051021,GO:0051046,GO:0051049,GO:0051179,GO:0051234,GO:0051301,GO:0051640,GO:0051641,GO:0051649,GO:0051716,GO:0055037,GO:0055057,GO:0055059,GO:0060429,GO:0060627,GO:0061351,GO:0061564,GO:0061951,GO:0065007,GO:0070382,GO:0070727,GO:0070887,GO:0070972,GO:0071236,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0072089,GO:0072594,GO:0072599,GO:0072657,GO:0072659,GO:0090150,GO:0097051,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098722,GO:0098791,GO:0098805,GO:0098827,GO:0098876,GO:0099503,GO:0120025,GO:0120036,GO:0120039,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903361,GO:1903530,GO:1990778	-	ko:K07903	ko04144,ko04152,map04144,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_417435_1	1345697.M493_14075	6.11e-97	329.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,4H9SM@91061|Bacilli,1WFYT@129337|Geobacillus	91061|Bacilli	G	M42 glutamyl aminopeptidase	ysdC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
YHH3_k127_417435_0	224324.aq_1763	8.35e-110	364.0	COG1260@1|root,COG1260@2|Bacteria,2G3U0@200783|Aquificae	200783|Aquificae	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
YHH3_k127_420473_1	399550.Smar_1074	4.052e-08	54.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
YHH3_k127_420473_0	72664.XP_006416164.1	2.893e-14	80.0	KOG0394@1|root,KOG0394@2759|Eukaryota,37R7D@33090|Viridiplantae,3G8FV@35493|Streptophyta	35493|Streptophyta	U	Ras-related protein	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0008150,GO:0008219,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010087,GO:0010089,GO:0010506,GO:0010508,GO:0010623,GO:0012501,GO:0017076,GO:0019001,GO:0019222,GO:0030154,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048468,GO:0048518,GO:0048522,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1905177	-	ko:K07897	ko04137,ko04138,ko04140,ko04144,ko04145,ko05132,ko05146,ko05152,map04137,map04138,map04140,map04144,map04145,map05132,map05146,map05152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_4205667_2	926569.ANT_14770	4.846e-56	205.0	COG2519@1|root,COG2519@2|Bacteria,2G8GD@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
YHH3_k127_4205667_4	644281.MFS40622_1836	7.355e-43	179.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,23Q54@183939|Methanococci	183939|Methanococci	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
YHH3_k127_4205667_8	69014.TK1599	6.056e-17	90.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,243A6@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
YHH3_k127_4205667_9	1198449.ACAM_1459	8.112e-11	68.0	COG0636@1|root,arCOG02455@2157|Archaea,2XR87@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase proteolipid subunit family	atpP	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
YHH3_k127_4205667_7	1041930.Mtc_2336	1.759e-18	97.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
YHH3_k127_4205667_3	1054217.TALC_01392	9.544e-46	181.0	COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
YHH3_k127_4205667_0	1382304.JNIL01000001_gene1376	5.967e-124	414.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4H9W6@91061|Bacilli	91061|Bacilli	G	Belongs to the FGGY kinase family	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
YHH3_k127_4205667_10	1134413.ANNK01000168_gene636	5.323e-10	64.0	COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,4HNHJ@91061|Bacilli,1ZIXI@1386|Bacillus	91061|Bacilli	L	endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
YHH3_k127_4205667_1	246194.CHY_1057	1.844e-71	252.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,42JFW@68295|Thermoanaerobacterales	186801|Clostridia	M	RmlD substrate binding domain	-	-	4.1.1.35,5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274,ko:K08678	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R01384,R02984,R05176	RC00289,RC00508,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
YHH3_k127_4205667_5	436308.Nmar_0067	1.366e-32	148.0	COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
YHH3_k127_4230500_0	1220534.B655_1784	2.05e-120	399.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23PD9@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
YHH3_k127_4230500_1	1121946.AUAX01000021_gene8088	5.787e-99	335.0	COG0473@1|root,COG0473@2|Bacteria,2I8V7@201174|Actinobacteria	201174|Actinobacteria	CE	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
YHH3_k127_4230500_2	345219.Bcoa_1587	5.349e-75	262.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,4HCBR@91061|Bacilli,1ZCHF@1386|Bacillus	91061|Bacilli	Q	COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	-	-	3.7.1.5	ko:K16164	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
YHH3_k127_4230500_3	56107.Cylst_4451	1.95e-25	115.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1HIQE@1161|Nostocales	1117|Cyanobacteria	K	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
YHH3_k127_4232124_3	1324957.K933_00177	1.383e-30	132.0	COG1992@1|root,arCOG00021@2157|Archaea,2XTP7@28890|Euryarchaeota,23SNG@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN2	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
YHH3_k127_4232124_2	391623.TERMP_01742	8.756e-64	233.0	COG4143@1|root,arCOG00226@2157|Archaea,2XT44@28890|Euryarchaeota,24311@183968|Thermococci	183968|Thermococci	H	ABC-type thiamine transport system, periplasmic component	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
YHH3_k127_4232124_1	69014.TK0159	3.329e-75	273.0	COG1178@1|root,arCOG00163@2157|Archaea,2XU8Q@28890|Euryarchaeota,243EI@183968|Thermococci	183968|Thermococci	P	transport system permease	-	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
YHH3_k127_4232124_0	488538.SAR116_1724	7.239e-79	275.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,4BPUN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
YHH3_k127_4232124_4	546268.NEISUBOT_03936	1.27e-09	64.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria,2KREG@206351|Neisseriales	206351|Neisseriales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
YHH3_k127_4232124_5	944546.ABED_0908	3.108e-08	58.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42R15@68525|delta/epsilon subdivisions,2YNVA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
YHH3_k127_4233512_6	693661.Arcve_1321	0.0001104	48.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2465H@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
YHH3_k127_4233512_5	1034807.FBFL15_1098	1.608e-08	63.0	COG4894@1|root,COG4894@2|Bacteria,4NK2I@976|Bacteroidetes,1ICNE@117743|Flavobacteriia,2NTRI@237|Flavobacterium	976|Bacteroidetes	S	Scramblase	-	-	-	-	-	-	-	-	-	-	-	-	Scramblase
YHH3_k127_4233512_4	1280689.AUJC01000001_gene2312	3.936e-14	75.0	COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,36MRK@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
YHH3_k127_4233512_2	1131266.ARWQ01000005_gene814	2.332e-100	340.0	COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
YHH3_k127_4233512_0	694429.Pyrfu_0957	8.029e-202	646.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
YHH3_k127_4233512_1	186497.PF1461	5.001e-125	415.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2439K@183968|Thermococci	183968|Thermococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
YHH3_k127_4233512_3	795666.MW7_0932	1.366e-18	93.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,1K1C3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
YHH3_k127_4263487_2	1347087.CBYO010000016_gene2564	2.073e-75	267.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,4HDFT@91061|Bacilli	91061|Bacilli	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
YHH3_k127_4263487_0	1121472.AQWN01000007_gene1130	7.354e-121	395.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
YHH3_k127_4263487_1	1408254.T458_13050	9.402e-97	329.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEA@91061|Bacilli,26T8K@186822|Paenibacillaceae	91061|Bacilli	C	(E1) component, eukaryotic type, alpha subunit	acoA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
YHH3_k127_4263487_3	221288.JH992901_gene4547	4.28e-35	143.0	COG0500@1|root,COG2226@2|Bacteria,1GHTA@1117|Cyanobacteria,1JKE0@1189|Stigonemataceae	1117|Cyanobacteria	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
YHH3_k127_4263487_4	1184251.TCELL_0968	1.095e-16	91.0	arCOG04555@1|root,arCOG04555@2157|Archaea	2157|Archaea	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
YHH3_k127_4289234_0	195522.BD01_1440	9.88e-63	227.0	COG1109@1|root,arCOG00767@2157|Archaea,2XTYZ@28890|Euryarchaeota,242U1@183968|Thermococci	183968|Thermococci	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.7	ko:K22199	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
YHH3_k127_4301184_3	1123373.ATXI01000012_gene948	7.996e-11	66.0	COG0713@1|root,COG0713@2|Bacteria,2GHZC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
YHH3_k127_4301184_2	192952.MM_2489	1.009e-20	98.0	COG0852@1|root,arCOG01551@2157|Archaea,2XZK1@28890|Euryarchaeota,2NA35@224756|Methanomicrobia	224756|Methanomicrobia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.5.98.3	ko:K22160	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Complex1_30kDa
YHH3_k127_4301184_0	374847.Kcr_0139	6.008e-67	242.0	COG0649@1|root,arCOG01548@2157|Archaea	2157|Archaea	C	COG0852 NADH ubiquinone oxidoreductase 27 kD subunit	nuoD	-	1.1.98.4,1.6.5.3	ko:K00333,ko:K13378,ko:K22172,ko:K22173	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
YHH3_k127_4301184_1	1262449.CP6013_1974	2.468e-54	205.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,36EBY@31979|Clostridiaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
YHH3_k127_4301184_4	289376.THEYE_A1124	0.0001259	47.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3,1.6.99.3	ko:K00338,ko:K02573,ko:K03941	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	Fer4,Fer4_7
YHH3_k127_4305599_0	319795.Dgeo_1506	6.867e-46	174.0	COG0584@1|root,COG0584@2|Bacteria,1WKK6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
YHH3_k127_4305599_1	515635.Dtur_0697	2.715e-42	162.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_436156_0	264732.Moth_0433	6.381e-17	86.0	COG1553@1|root,COG1553@2|Bacteria,1VG50@1239|Firmicutes,24R7R@186801|Clostridia,42H7U@68295|Thermoanaerobacterales	186801|Clostridia	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
YHH3_k127_436156_1	194439.CT0856	4.259e-09	62.0	COG2923@1|root,COG2923@2|Bacteria,1FF55@1090|Chlorobi	1090|Chlorobi	P	PFAM DsrE family protein	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
YHH3_k127_436156_2	419665.Maeo_0965	0.0003393	47.0	arCOG05131@1|root,arCOG05131@2157|Archaea	2157|Archaea	S	DsrH like protein	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
YHH3_k127_4362945_0	523850.TON_1845	5.857e-24	104.0	COG1487@1|root,arCOG02219@2157|Archaea,2Y4FC@28890|Euryarchaeota,244JI@183968|Thermococci	183968|Thermococci	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
YHH3_k127_4362945_2	387631.Asulf_01413	0.0006171	45.0	arCOG04141@1|root,arCOG04141@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
YHH3_k127_4362945_1	272557.APE_0275a	1.079e-10	63.0	COG5428@1|root,arCOG02270@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
YHH3_k127_4365267_5	374847.Kcr_0075	1.407e-23	106.0	COG0648@1|root,arCOG01894@2157|Archaea	2157|Archaea	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
YHH3_k127_4365267_1	760568.Desku_0277	2.975e-56	200.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1V3TD@1239|Firmicutes,24I7A@186801|Clostridia,261TJ@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4365267_4	1056495.Calag_0209	2.447e-30	132.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQNM@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
YHH3_k127_4365267_7	573064.Mefer_0901	7.404e-16	82.0	COG3355@1|root,arCOG02242@2157|Archaea,2XY1Y@28890|Euryarchaeota,23R13@183939|Methanococci	183939|Methanococci	K	PFAM Transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH3_k127_4365267_2	868131.MSWAN_0445	1.749e-54	198.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,23NUM@183925|Methanobacteria	183925|Methanobacteria	O	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
YHH3_k127_4365267_6	224719.Abm4_1536	1.298e-19	98.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,23NQ6@183925|Methanobacteria	183925|Methanobacteria	S	Pheromone shutdown	-	-	-	-	-	-	-	-	-	-	-	-	TraB
YHH3_k127_4365267_3	935836.JAEL01000068_gene1771	6.378e-51	186.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,4HH5X@91061|Bacilli,1ZHJE@1386|Bacillus	91061|Bacilli	K	GrpB protein	yqkA	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,GrpB
YHH3_k127_4365267_0	1265505.ATUG01000002_gene2429	2.985e-123	406.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
YHH3_k127_4365267_8	1121875.KB907549_gene1925	1.263e-08	64.0	2AIE8@1|root,318VP@2|Bacteria,4NQHF@976|Bacteroidetes,1I39Y@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4365267_9	941639.BCO26_0885	1.331e-05	56.0	COG1522@1|root,COG1522@2|Bacteria,1V1DR@1239|Firmicutes,4HFRT@91061|Bacilli,1ZG22@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	ywrC	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_4402754_5	877455.Metbo_1600	6.582e-12	80.0	arCOG02487@1|root,arCOG02555@1|root,arCOG03270@1|root,arCOG02487@2157|Archaea,arCOG02555@2157|Archaea,arCOG03270@2157|Archaea,2Y7UE@28890|Euryarchaeota,23PA5@183925|Methanobacteria	183925|Methanobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
YHH3_k127_4402754_6	342949.PNA2_1011	8.145e-12	78.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,243S2@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
YHH3_k127_4402754_0	195522.BD01_1777	9.392e-100	335.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
YHH3_k127_4402754_2	765420.OSCT_1333	3.368e-35	150.0	COG1721@1|root,COG1721@2|Bacteria,2G7PU@200795|Chloroflexi,375DS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
YHH3_k127_4402754_1	269797.Mbar_A0016	2.545e-51	194.0	COG0608@1|root,arCOG00424@2157|Archaea,2XVF6@28890|Euryarchaeota,2N93U@224756|Methanomicrobia	224756|Methanomicrobia	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
YHH3_k127_4402754_4	1041930.Mtc_1997	1.199e-15	92.0	COG1297@1|root,arCOG04807@2157|Archaea	2157|Archaea	S	Oligopeptide transporter OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
YHH3_k127_4402754_7	1183377.Py04_1557	2.319e-10	65.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,244II@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
YHH3_k127_4402754_3	521098.Aaci_2021	6.64e-17	88.0	COG0500@1|root,COG2226@2|Bacteria,1V7TR@1239|Firmicutes,4HJ1N@91061|Bacilli	91061|Bacilli	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
YHH3_k127_4424882_1	368407.Memar_2392	1.355e-16	92.0	COG2327@1|root,arCOG04826@2157|Archaea,2Y1DB@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
YHH3_k127_4424882_0	269797.Mbar_A2141	2.853e-33	144.0	COG0438@1|root,arCOG01410@2157|Archaea,2XV5R@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
YHH3_k127_4433452_0	1340434.AXVA01000008_gene3814	3.132e-10	71.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
YHH3_k127_4433452_1	585394.RHOM_02905	6.96e-07	55.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	Acyl_transf_3,DUF4153
YHH3_k127_4434981_0	1355368.JART01000028_gene1658	1.479e-11	78.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2YN79@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	ThiF family	thiF	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
YHH3_k127_4434981_1	1434325.AZQN01000003_gene2484	1.784e-11	75.0	COG1305@1|root,COG1305@2|Bacteria,4NHV0@976|Bacteroidetes,47JVZ@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
YHH3_k127_4442512_0	304371.MCP_2864	1.341e-44	178.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_4483324_0	490899.DKAM_1259	3.076e-12	72.0	COG1958@1|root,arCOG00999@2157|Archaea,2XR1U@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
YHH3_k127_4484528_1	1408428.JNJP01000001_gene3257	1.119e-28	122.0	COG0655@1|root,COG0655@2|Bacteria,1RD5X@1224|Proteobacteria,42T3S@68525|delta/epsilon subdivisions,2WN8N@28221|Deltaproteobacteria,2MBA8@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_4484528_2	572478.Vdis_1328	5.964e-23	104.0	arCOG07589@1|root,arCOG07589@2157|Archaea,2XS0I@28889|Crenarchaeota	28889|Crenarchaeota	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
YHH3_k127_4484528_3	999630.TUZN_0507	3.667e-13	75.0	COG1848@1|root,arCOG02221@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
YHH3_k127_4484528_0	616991.JPOO01000001_gene4601	2.722e-30	124.0	COG5580@1|root,COG5580@2|Bacteria,4PK53@976|Bacteroidetes,1I3SX@117743|Flavobacteriia	976|Bacteroidetes	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
YHH3_k127_4484528_4	192952.MM_2605	0.0001268	44.0	COG2026@1|root,arCOG01665@2157|Archaea	2157|Archaea	DJ	PFAM plasmid stabilization system	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
YHH3_k127_4495636_1	246194.CHY_1732	9.871e-67	235.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42I2K@68295|Thermoanaerobacterales	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
YHH3_k127_4495636_5	439235.Dalk_2542	7.556e-15	84.0	COG0778@1|root,COG1143@1|root,COG0778@2|Bacteria,COG1143@2|Bacteria,1R4E3@1224|Proteobacteria,42RVJ@68525|delta/epsilon subdivisions,2WNCQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Nitroreductase
YHH3_k127_4495636_0	444157.Tneu_0832	1.194e-98	336.0	COG0119@1|root,arCOG02092@2157|Archaea,2XPY3@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
YHH3_k127_4495636_3	1457250.BBMO01000002_gene2464	8.597e-41	159.0	COG0500@1|root,arCOG04734@2157|Archaea,2XWDH@28890|Euryarchaeota,23V0A@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
YHH3_k127_4495636_4	1223545.GS4_02_00170	1.578e-32	133.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,4GBWM@85026|Gordoniaceae	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	gca	-	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep
YHH3_k127_4495636_7	1121920.AUAU01000007_gene538	6.446e-05	52.0	COG1764@1|root,COG1764@2|Bacteria,3Y8XQ@57723|Acidobacteria	57723|Acidobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
YHH3_k127_4495636_6	1122609.AUGT01000031_gene2592	3.003e-11	72.0	2AZAV@1|root,31RI7@2|Bacteria,2GPFX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4495636_2	1192034.CAP_0500	4.015e-55	205.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2Z33Y@29|Myxococcales	28221|Deltaproteobacteria	M	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
YHH3_k127_4508716_0	1343739.PAP_02470	4.186e-118	396.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,242NX@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_4508716_1	604354.TSIB_1366	8.046e-76	271.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,242W4@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_4508716_4	457429.ABJI02000575_gene729	2.562e-17	98.0	COG1404@1|root,COG1404@2|Bacteria,2IFQ2@201174|Actinobacteria	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_4508716_3	243232.MJ_0649	3.22e-43	174.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,23Q75@183939|Methanococci	183939|Methanococci	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
YHH3_k127_4508716_2	1122611.KB903952_gene5889	5.417e-48	198.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4ENKK@85012|Streptosporangiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
YHH3_k127_4512155_0	246194.CHY_2031	5.632e-34	141.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	1239|Firmicutes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
YHH3_k127_4541846_1	684949.ATTJ01000002_gene179	3.689e-06	58.0	COG0454@1|root,COG0456@2|Bacteria,1WMYB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_4541846_2	1206777.B195_04766	0.0001316	52.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1Z6R3@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
YHH3_k127_4541846_0	720554.Clocl_3980	1.139e-143	469.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,3WHD2@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
YHH3_k127_4561053_3	345219.Bcoa_3063	3.026e-19	93.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli,1ZCQN@1386|Bacillus	91061|Bacilli	C	Glycolate oxidase subunit	dld	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_4561053_0	656519.Halsa_1020	2.297e-81	284.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,25N8F@186801|Clostridia,3WBM2@53433|Halanaerobiales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
YHH3_k127_4561053_2	639030.JHVA01000001_gene2959	4.941e-29	125.0	COG0684@1|root,COG0684@2|Bacteria,3Y788@57723|Acidobacteria	57723|Acidobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
YHH3_k127_4561053_1	1183377.Py04_1216	9.552e-41	156.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,242SN@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
YHH3_k127_4561484_3	195522.BD01_0563	1.863e-15	82.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
YHH3_k127_4561484_1	386456.JQKN01000016_gene901	3.817e-24	114.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_4561484_0	1128421.JAGA01000001_gene2334	2.809e-26	122.0	COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria	2|Bacteria	M	glycosyl transferase group 1	bplH	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_trans_4_4,Glycos_transf_1
YHH3_k127_4561484_2	696281.Desru_2570	4.577e-23	98.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,2635N@186807|Peptococcaceae	186801|Clostridia	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA,Glyco_hydro_18
YHH3_k127_4566044_7	1227360.C176_14962	9.107e-20	100.0	COG1378@1|root,COG1378@2|Bacteria,1UV3K@1239|Firmicutes,4IR5F@91061|Bacilli	91061|Bacilli	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
YHH3_k127_4566044_0	1304865.JAGF01000001_gene2184	3.814e-73	257.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH3_k127_4566044_10	686340.Metal_0970	3.791e-06	59.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XE23@135618|Methylococcales	135618|Methylococcales	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
YHH3_k127_4566044_8	1123321.KB905821_gene4303	3.632e-16	91.0	COG0842@1|root,COG0842@2|Bacteria,2H248@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
YHH3_k127_4566044_6	1437425.CSEC_0941	4.157e-22	106.0	COG0454@1|root,COG0456@2|Bacteria,2JGP6@204428|Chlamydiae	204428|Chlamydiae	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_4566044_4	370438.PTH_0628	7.291e-41	166.0	COG0477@1|root,COG2814@2|Bacteria,1UGP8@1239|Firmicutes,24ENP@186801|Clostridia,263QB@186807|Peptococcaceae	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_4566044_11	1151061.CAJY01000028_gene1090	5.419e-05	51.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	nfeD	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
YHH3_k127_4566044_1	1329516.JPST01000005_gene1384	5.753e-54	203.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,4H9SM@91061|Bacilli	91061|Bacilli	G	COG1363 Cellulase M and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
YHH3_k127_4566044_5	237368.SCABRO_02464	3.654e-23	111.0	28K4S@1|root,30U3F@2|Bacteria,2J1UP@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4566044_2	224325.AF_1469	2.999e-50	186.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2460M@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_4566044_3	313606.M23134_01060	5.811e-41	166.0	COG4591@1|root,COG4591@2|Bacteria,4PATB@976|Bacteroidetes,47UGK@768503|Cytophagia	976|Bacteroidetes	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
YHH3_k127_4566044_9	216596.RL2172	1.33e-12	76.0	COG4249@1|root,COG4249@2|Bacteria,1MXS7@1224|Proteobacteria,2U4FS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
YHH3_k127_4571219_0	509191.AEDB02000002_gene1213	2.397e-91	313.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,24BGZ@186801|Clostridia,3WJAE@541000|Ruminococcaceae	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17,Fer4_9
YHH3_k127_458910_2	1306990.BARG01000006_gene362	0.0004192	53.0	COG4085@1|root,COG4085@2|Bacteria,2GP86@201174|Actinobacteria	201174|Actinobacteria	E	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,He_PIG
YHH3_k127_458910_0	386456.JQKN01000004_gene228	3.189e-48	178.0	COG0500@1|root,arCOG01631@2157|Archaea	2157|Archaea	Q	RNA methylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	CMAS,DOT1,Methyltransf_25,Methyltransf_31,PrmA
YHH3_k127_458910_1	906888.JCM19314_904	1.517e-09	70.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4614273_2	246194.CHY_2670	7.869e-87	297.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,42FKX@68295|Thermoanaerobacterales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
YHH3_k127_4614273_0	453591.Igni_1108	2.476e-90	314.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
YHH3_k127_4614273_1	304371.MCP_2982	3.56e-89	298.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
YHH3_k127_4637656_0	644281.MFS40622_0209	1.485e-146	475.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
YHH3_k127_4637656_1	246194.CHY_0930	1.131e-92	317.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,42FM3@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,Pyr_redox_2
YHH3_k127_465758_3	891968.Anamo_1487	9.75e-52	188.0	COG1003@1|root,COG1003@2|Bacteria,3TAQ0@508458|Synergistetes	2|Bacteria	E	Glycine dehydrogenase (aminomethyl-transferring)	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
YHH3_k127_465758_2	592015.HMPREF1705_01651	2.208e-118	391.0	COG3199@1|root,COG3199@2|Bacteria,3T9RA@508458|Synergistetes	508458|Synergistetes	H	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
YHH3_k127_465758_11	387631.Asulf_02153	1.325e-17	93.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,246UU@183980|Archaeoglobi	183980|Archaeoglobi	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
YHH3_k127_465758_5	374847.Kcr_0495	3.291e-40	154.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_IclR,TrmB
YHH3_k127_465758_4	931626.Awo_c22580	7.748e-48	174.0	COG1148@1|root,COG1148@2|Bacteria,1V4NY@1239|Firmicutes,24IAD@186801|Clostridia,25YHD@186806|Eubacteriaceae	186801|Clostridia	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_465758_8	2325.TKV_c19110	1.437e-28	117.0	COG1146@1|root,COG1146@2|Bacteria,1VAMF@1239|Firmicutes,24ND9@186801|Clostridia,42IEN@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
YHH3_k127_465758_6	931626.Awo_c22560	3.324e-34	142.0	COG0509@1|root,COG4273@1|root,COG0509@2|Bacteria,COG4273@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,25YAR@186806|Eubacteriaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	DGC,GCV_H
YHH3_k127_465758_10	1031288.AXAA01000034_gene2179	1.053e-17	87.0	COG4273@1|root,COG4273@2|Bacteria,1VBRH@1239|Firmicutes,24N2C@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
YHH3_k127_465758_9	1031288.AXAA01000034_gene2178	1.524e-27	116.0	2DMSV@1|root,32TFU@2|Bacteria,1VC0G@1239|Firmicutes,24Q3V@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
YHH3_k127_465758_12	398767.Glov_1189	1.965e-17	85.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
YHH3_k127_465758_7	56780.SYN_02919	9.832e-31	128.0	COG0350@1|root,COG0500@1|root,COG0350@2|Bacteria,COG2226@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
YHH3_k127_465758_13	742743.HMPREF9453_00915	9.527e-14	81.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,4H5JY@909932|Negativicutes	909932|Negativicutes	M	Transporter, small conductance mechanosensitive ion channel MscS family protein	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
YHH3_k127_465758_0	439235.Dalk_4525	2.817e-133	437.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2WJQW@28221|Deltaproteobacteria,2MHRC@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
YHH3_k127_465758_1	502025.Hoch_3072	3.036e-120	394.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
YHH3_k127_4670622_0	386456.JQKN01000002_gene2730	1.738e-134	446.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
YHH3_k127_4670622_1	865861.AZSU01000001_gene147	1.629e-31	128.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,36DUF@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_4677708_5	1120949.KB903339_gene7992	1.357e-24	107.0	2DMR3@1|root,32T4S@2|Bacteria,2I7IG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4677708_3	1111134.HMPREF1253_1239	4.463e-72	254.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,22G19@1570339|Peptoniphilaceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
YHH3_k127_4677708_2	1499967.BAYZ01000160_gene414	5.382e-82	286.0	COG1524@1|root,COG1524@2|Bacteria,2NQ0M@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
YHH3_k127_4677708_4	411902.CLOBOL_00399	7.537e-26	115.0	2EA6W@1|root,334BM@2|Bacteria,1VGW9@1239|Firmicutes,24R9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4677708_6	1295642.H839_06519	4.77e-24	119.0	COG1525@1|root,COG3204@1|root,COG1525@2|Bacteria,COG3204@2|Bacteria,1V7X8@1239|Firmicutes,4HJJI@91061|Bacilli,1WH7K@129337|Geobacillus	91061|Bacilli	L	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	LTD,SNase
YHH3_k127_4677708_0	861299.J421_0531	2.16e-276	882.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
YHH3_k127_4677708_12	1122929.KB908224_gene3456	0.0001422	53.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VG6E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, AsnC family	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
YHH3_k127_4677708_11	469382.Hbor_03240	4.929e-06	52.0	COG0640@1|root,arCOG00394@2157|Archaea,2XZWN@28890|Euryarchaeota,23Y93@183963|Halobacteria	183963|Halobacteria	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH3_k127_4677708_8	999630.TUZN_0678	2.71e-23	105.0	COG0727@1|root,arCOG02579@2157|Archaea,2XR8B@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
YHH3_k127_4677708_7	374847.Kcr_1553	4.918e-24	108.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_4677708_1	309801.trd_1557	9.586e-94	323.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,27XSZ@189775|Thermomicrobia	189775|Thermomicrobia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
YHH3_k127_4677708_10	1048339.KB913029_gene3229	6.044e-08	61.0	2EHBA@1|root,33B35@2|Bacteria,2I3RH@201174|Actinobacteria	201174|Actinobacteria	S	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
YHH3_k127_4677708_9	1200557.JHWV01000001_gene547	2.599e-17	83.0	2DNM3@1|root,32Y2K@2|Bacteria,1UKQ2@1239|Firmicutes,4H9CB@909932|Negativicutes	909932|Negativicutes	S	cluster protein-associated redox disulfide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
YHH3_k127_4692761_0	391625.PPSIR1_35652	1.659e-61	235.0	COG0433@1|root,COG0433@2|Bacteria,1R7B1@1224|Proteobacteria,42NW4@68525|delta/epsilon subdivisions,2X6WX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4692761_1	351160.RCIX2602	1.399e-34	141.0	COG3382@1|root,arCOG04250@2157|Archaea,2Y2KD@28890|Euryarchaeota,2NAIE@224756|Methanomicrobia	224756|Methanomicrobia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
YHH3_k127_4704137_0	1379698.RBG1_1C00001G1511	4.368e-146	477.0	COG0312@1|root,COG0312@2|Bacteria,2NPIS@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_4728644_2	880073.Calab_2401	5.27e-05	53.0	COG2374@1|root,COG2374@2|Bacteria,2NRB5@2323|unclassified Bacteria	2|Bacteria	G	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1,Exo_endo_phos,FlgD_ig,LTD
YHH3_k127_4728644_0	679926.Mpet_0288	4.091e-22	105.0	arCOG02385@1|root,arCOG03567@1|root,arCOG06516@1|root,arCOG02385@2157|Archaea,arCOG03567@2157|Archaea,arCOG06516@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9,Response_reg
YHH3_k127_4728644_1	1094980.Mpsy_1693	3.515e-06	57.0	COG2202@1|root,arCOG02330@1|root,arCOG02339@1|root,arCOG02330@2157|Archaea,arCOG02339@2157|Archaea,arCOG06918@2157|Archaea,2Y7N0@28890|Euryarchaeota,2NBKC@224756|Methanomicrobia	224756|Methanomicrobia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,PAS_3
YHH3_k127_4752_0	1121335.Clst_0501	1.468e-194	617.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WGEA@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
YHH3_k127_4752_1	391623.TERMP_00066	3.825e-91	308.0	COG0543@1|root,arCOG02199@2157|Archaea,2XTVJ@28890|Euryarchaeota,243NE@183968|Thermococci	183968|Thermococci	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	1.8.1.19	ko:K20203	-	-	-	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind
YHH3_k127_4752_3	866771.HMPREF9296_0494	5.533e-39	165.0	COG2304@1|root,COG2304@2|Bacteria,4P02M@976|Bacteroidetes,2FX22@200643|Bacteroidia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
YHH3_k127_4752_2	1349822.NSB1T_02885	4.243e-74	271.0	COG0714@1|root,COG0714@2|Bacteria,4PAE8@976|Bacteroidetes,2FWQG@200643|Bacteroidia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
YHH3_k127_4752_4	604354.TSIB_0136	2.615e-13	80.0	COG0730@1|root,arCOG02050@2157|Archaea,2XSTS@28890|Euryarchaeota,243BP@183968|Thermococci	183968|Thermococci	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
YHH3_k127_4767089_1	386456.JQKN01000017_gene841	1.119e-57	213.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4767089_0	1278073.MYSTI_03346	1.889e-65	229.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
YHH3_k127_4777719_0	673860.AciM339_1034	9.925e-108	358.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,3F2EY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
YHH3_k127_4789716_1	334390.LAF_1714	7.396e-05	53.0	2E39Q@1|root,32Y99@2|Bacteria,1VQQ8@1239|Firmicutes,4HRY1@91061|Bacilli,3F4UX@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4789716_0	1385935.N836_05515	4.241e-54	193.0	COG0262@1|root,COG0262@2|Bacteria,1G6JU@1117|Cyanobacteria,1HCBU@1150|Oscillatoriales	1117|Cyanobacteria	H	dihydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
YHH3_k127_4790211_1	1220534.B655_1002	4.685e-05	54.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
YHH3_k127_4790211_0	332101.JIBU02000023_gene4700	2.4e-45	168.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia,36M8N@31979|Clostridiaceae	186801|Clostridia	I	PFAM MaoC domain protein dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
YHH3_k127_4795531_2	309801.trd_0361	9.111e-21	102.0	COG2220@1|root,COG2220@2|Bacteria,2GBQC@200795|Chloroflexi,27YVZ@189775|Thermomicrobia	189775|Thermomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
YHH3_k127_4795531_1	871963.Desdi_2250	2.622e-36	148.0	COG1148@1|root,COG1148@2|Bacteria,1UM46@1239|Firmicutes,25GAD@186801|Clostridia	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_4795531_3	203119.Cthe_1509	5.363e-07	57.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
YHH3_k127_4795531_0	639282.DEFDS_1228	3.257e-154	495.0	COG4799@1|root,COG4799@2|Bacteria,2GEP0@200930|Deferribacteres	200930|Deferribacteres	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
YHH3_k127_4801523_3	639282.DEFDS_0706	9.047e-43	168.0	COG0672@1|root,COG0672@2|Bacteria,2GGKP@200930|Deferribacteres	200930|Deferribacteres	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
YHH3_k127_4801523_5	1117379.BABA_13572	2.613e-16	84.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,4HJMF@91061|Bacilli,1ZH6V@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
YHH3_k127_4801523_2	1499685.CCFJ01000046_gene3236	1.482e-46	173.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,4HIZ3@91061|Bacilli,1ZQFD@1386|Bacillus	91061|Bacilli	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
YHH3_k127_4801523_4	1410653.JHVC01000007_gene628	1.514e-34	142.0	COG0500@1|root,COG2226@2|Bacteria,1UFKC@1239|Firmicutes,24H53@186801|Clostridia,36I5D@31979|Clostridiaceae	186801|Clostridia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
YHH3_k127_4801523_0	1499967.BAYZ01000028_gene1366	1.001e-141	468.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
YHH3_k127_4801523_1	351160.LRC377	1.09e-56	222.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_4803187_1	530564.Psta_4266	1.594e-24	108.0	COG0720@1|root,COG0720@2|Bacteria,2IZMP@203682|Planctomycetes	203682|Planctomycetes	H	COG0720 6-pyruvoyl-tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
YHH3_k127_4803187_0	70601.3258219	6.08e-60	217.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,243S1@183968|Thermococci	183968|Thermococci	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
YHH3_k127_4817154_2	584708.Apau_0482	1.503e-47	177.0	COG1528@1|root,COG1528@2|Bacteria,3TB3G@508458|Synergistetes	508458|Synergistetes	P	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
YHH3_k127_4817154_0	1157490.EL26_11975	1.65e-75	278.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
YHH3_k127_4817154_5	69014.TK2128	3.581e-19	93.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2441Z@183968|Thermococci	183968|Thermococci	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
YHH3_k127_4817154_1	589924.Ferp_1748	8.96e-68	246.0	COG0633@1|root,COG3894@1|root,arCOG02035@2157|Archaea,arCOG02842@2157|Archaea,2XVBE@28890|Euryarchaeota,246NQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
YHH3_k127_4817154_6	246194.CHY_0082	7.768e-19	91.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,42H8S@68295|Thermoanaerobacterales	186801|Clostridia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
YHH3_k127_4817154_4	224325.AF_2432	3.629e-22	100.0	COG1708@1|root,arCOG02107@2157|Archaea,2Y3U0@28890|Euryarchaeota,24744@183980|Archaeoglobi	183980|Archaeoglobi	S	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
YHH3_k127_4817154_3	565033.GACE_1638	4.222e-26	112.0	COG2445@1|root,arCOG02109@2157|Archaea,2XZVS@28890|Euryarchaeota,24755@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
YHH3_k127_4817154_8	604354.TSIB_1225	8.323e-16	83.0	COG2445@1|root,arCOG02108@2157|Archaea,2Y6E4@28890|Euryarchaeota,2448I@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
YHH3_k127_4817154_9	323259.Mhun_1046	2.927e-15	80.0	COG1708@1|root,arCOG02107@2157|Archaea	323259.Mhun_1046|-	S	DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4817154_7	1280682.AUKA01000003_gene1159	2.013e-16	83.0	COG2315@1|root,COG3695@1|root,COG2315@2|Bacteria,COG3695@2|Bacteria,1VC8H@1239|Firmicutes,24JGN@186801|Clostridia,4C20C@830|Butyrivibrio	186801|Clostridia	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
YHH3_k127_4817154_10	1122915.AUGY01000001_gene7164	7.683e-09	67.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,4HNJ9@91061|Bacilli,26XB5@186822|Paenibacillaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_4829335_1	7668.SPU_010148-tr	4.191e-15	76.0	COG2801@1|root,KOG0017@2759|Eukaryota,38GIZ@33154|Opisthokonta,3BMWT@33208|Metazoa,3CTK8@33213|Bilateria	33208|Metazoa	L	genomic stop codons	-	-	-	-	-	-	-	-	-	-	-	-	Gag_p30,RNase_H,RVP,RVT_1,rve,zf-CCHC
YHH3_k127_4829335_0	7668.SPU_016873-tr	4.683e-117	383.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
YHH3_k127_4836678_1	1131269.AQVV01000016_gene1859	1.059e-53	207.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
YHH3_k127_4836678_0	1041930.Mtc_0466	3.304e-57	217.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
YHH3_k127_4855671_2	1094980.Mpsy_3012	2.484e-79	273.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2N98S@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
YHH3_k127_4855671_1	387631.Asulf_00752	1.449e-89	305.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,24603@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
YHH3_k127_4855671_3	387631.Asulf_01598	3.745e-25	110.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,246AM@183980|Archaeoglobi	183980|Archaeoglobi	C	Formylmethanofuran dehydrogenase subunit D	-	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
YHH3_k127_4855671_0	891968.Anamo_1144	1.068e-101	342.0	COG1029@1|root,COG1029@2|Bacteria,3TBWP@508458|Synergistetes	508458|Synergistetes	C	Molybdopterin oxidoreductase	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
YHH3_k127_486267_0	391625.PPSIR1_36707	1.14e-43	164.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
YHH3_k127_486267_1	1121918.ARWE01000001_gene3370	1.432e-21	98.0	COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria	1224|Proteobacteria	P	iron permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
YHH3_k127_4867289_2	1499967.BAYZ01000190_gene3815	1.352e-21	98.0	COG3222@1|root,COG3222@2|Bacteria,2NRHT@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064,Glycos_transf_2
YHH3_k127_4867289_0	1322246.BN4_10887	4.624e-86	295.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,42QKH@68525|delta/epsilon subdivisions,2WMW7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
YHH3_k127_4867289_3	517418.Ctha_1610	1.551e-09	70.0	COG0457@1|root,COG0457@2|Bacteria,1FDGV@1090|Chlorobi	1090|Chlorobi	H	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
YHH3_k127_4867289_1	186497.PF1154	1.164e-70	244.0	COG0846@1|root,arCOG04248@2157|Archaea,2XT4V@28890|Euryarchaeota,2432W@183968|Thermococci	183968|Thermococci	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
YHH3_k127_4897812_0	1121405.dsmv_1706	5.12e-13	79.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2MIE6@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH3_k127_4907841_3	293826.Amet_0042	1.756e-09	60.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,36EX4@31979|Clostridiaceae	186801|Clostridia	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
YHH3_k127_4907841_0	1463885.KL578430_gene6947	1.697e-19	89.0	COG1670@1|root,COG1670@2|Bacteria,2HE22@201174|Actinobacteria	201174|Actinobacteria	J	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
YHH3_k127_4907841_2	1141662.OOA_17361	4.863e-11	75.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,1RR1T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Sugar (and other) transporter	dcaK	-	-	ko:K08196	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,Sugar_tr
YHH3_k127_4907841_1	428127.EUBDOL_00679	6.156e-13	70.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes	1239|Firmicutes	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	-	-	3.1.3.41	ko:K01101,ko:K02566	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
YHH3_k127_4925142_1	1379698.RBG1_1C00001G1614	1.145e-100	342.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
YHH3_k127_4925142_2	500153.JOEK01000009_gene5062	5.756e-78	269.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
YHH3_k127_4925142_0	671143.DAMO_1946	8.751e-126	439.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
YHH3_k127_4925142_3	1036674.A28LD_1478	3.311e-06	61.0	COG4386@1|root,COG4386@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,Laminin_G_3,Rib
YHH3_k127_4925142_4	583355.Caka_2166	1.73e-05	59.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	ko:K16191,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.6.1.3	-	-	BON,Gram_pos_anchor,OmpA,TSP_3
YHH3_k127_4936886_6	1122609.AUGT01000021_gene1265	1.193e-09	70.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	psrP1	-	-	ko:K12548,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_1,Big_3_5,CHU_C,DUF11,SWM_repeat,SdrD_B,SprB
YHH3_k127_4936886_0	1382304.JNIL01000001_gene3479	1.138e-133	437.0	COG2355@1|root,COG2355@2|Bacteria,1TRNQ@1239|Firmicutes,4HEBU@91061|Bacilli	91061|Bacilli	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
YHH3_k127_4936886_2	756883.Halar_1126	1.56e-43	168.0	COG1794@1|root,arCOG02006@2157|Archaea	2157|Archaea	M	Hydantoin racemase	-	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
YHH3_k127_4936886_7	671143.DAMO_0755	0.0005221	45.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
YHH3_k127_4936886_1	324925.Ppha_1488	5.771e-58	211.0	COG1194@1|root,COG1194@2|Bacteria,1FD5V@1090|Chlorobi	1090|Chlorobi	L	HhH-GPD family	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
YHH3_k127_4936886_4	511051.CSE_06700	3.672e-16	91.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,Peptidase_C14,TIR_2
YHH3_k127_4936886_5	158189.SpiBuddy_0682	1.874e-13	76.0	COG0716@1|root,COG0716@2|Bacteria,2JAHG@203691|Spirochaetes	203691|Spirochaetes	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4936886_3	1150474.JQJI01000049_gene1082	1.236e-35	139.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
YHH3_k127_494627_4	2903.EOD25313	1.347e-06	53.0	KOG3457@1|root,KOG3457@2759|Eukaryota	2759|Eukaryota	U	posttranslational protein targeting to membrane, translocation	SEC61B	GO:0000060,GO:0003674,GO:0005085,GO:0005086,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005784,GO:0005789,GO:0005791,GO:0005829,GO:0006508,GO:0006511,GO:0006605,GO:0006606,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006620,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006950,GO:0006996,GO:0007029,GO:0008104,GO:0008150,GO:0008152,GO:0008320,GO:0008565,GO:0009056,GO:0009057,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010033,GO:0010243,GO:0010256,GO:0010498,GO:0010506,GO:0010507,GO:0012505,GO:0015031,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0017038,GO:0019222,GO:0019538,GO:0019838,GO:0019899,GO:0019941,GO:0022804,GO:0022857,GO:0022884,GO:0030163,GO:0030433,GO:0030867,GO:0030970,GO:0031090,GO:0031204,GO:0031205,GO:0031224,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031984,GO:0032527,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034504,GO:0034613,GO:0034976,GO:0036503,GO:0042175,GO:0042221,GO:0042562,GO:0042886,GO:0042887,GO:0043021,GO:0043022,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044322,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045047,GO:0045048,GO:0045184,GO:0046907,GO:0048408,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051169,GO:0051170,GO:0051179,GO:0051205,GO:0051234,GO:0051603,GO:0051641,GO:0051649,GO:0051716,GO:0055085,GO:0061024,GO:0065002,GO:0065007,GO:0065009,GO:0070727,GO:0070972,GO:0071256,GO:0071261,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071816,GO:0071840,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0098588,GO:0098772,GO:0098796,GO:0098827,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1903513,GO:1904680	3.1.3.16	ko:K08472,ko:K09481,ko:K15731	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko01000,ko01009,ko02044,ko03021,ko04030	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Sec61_beta
YHH3_k127_494627_1	1184251.TCELL_0130	8.788e-27	112.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
YHH3_k127_494627_2	391623.TERMP_00374	3.107e-14	74.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,244JK@183968|Thermococci	183968|Thermococci	J	ribosomal protein	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
YHH3_k127_494627_0	579137.Metvu_1196	1.991e-55	203.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,23PZU@183939|Methanococci	183939|Methanococci	J	Translation initiation factor 2	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
YHH3_k127_494627_3	384616.Pisl_0432	2.22e-10	62.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
YHH3_k127_4949802_1	1048339.KB913029_gene4202	4.711e-17	96.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_4949802_0	203119.Cthe_1763	1.526e-66	237.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,3WGVE@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_4962333_2	1094508.Tsac_2671	1.477e-13	76.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,42F50@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.45,4.2.1.46	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R02426,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
YHH3_k127_4962333_0	1499967.BAYZ01000154_gene1533	6.934e-51	190.0	COG0084@1|root,COG0084@2|Bacteria,2NP9H@2323|unclassified Bacteria	2|Bacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
YHH3_k127_4962333_1	1121289.JHVL01000013_gene1670	2.313e-24	112.0	COG0438@1|root,COG0438@2|Bacteria,1V0G0@1239|Firmicutes,25BFP@186801|Clostridia,36WFX@31979|Clostridiaceae	186801|Clostridia	M	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
YHH3_k127_496853_0	387631.Asulf_01754	1.671e-65	233.0	COG2141@1|root,arCOG02410@2157|Archaea,2XV6G@28890|Euryarchaeota,246P8@183980|Archaeoglobi	183980|Archaeoglobi	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
YHH3_k127_496853_1	273057.SSO0432	1.009e-48	180.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
YHH3_k127_496853_2	436308.Nmar_0114	3.81e-41	161.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,TrmB
YHH3_k127_4969195_0	1304284.L21TH_0179	3.855e-231	726.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36HQZ@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh,Pro_dh
YHH3_k127_4969195_4	604354.TSIB_1838	2.177e-21	101.0	COG1853@1|root,arCOG02017@2157|Archaea,2XX0G@28890|Euryarchaeota,243H5@183968|Thermococci	183968|Thermococci	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
YHH3_k127_4969195_2	868131.MSWAN_0191	9.226e-113	370.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,23PWY@183925|Methanobacteria	183925|Methanobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
YHH3_k127_4969195_1	403833.Pmob_0458	2.815e-194	621.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GC9M@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	POR,POR_N
YHH3_k127_4969195_3	572478.Vdis_1620	1.035e-55	201.0	COG1028@1|root,arCOG01259@2157|Archaea,2XQE9@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
YHH3_k127_4975981_1	1117319.PSPO_21164	0.0001073	54.0	COG1404@1|root,COG5183@1|root,COG1404@2|Bacteria,COG5183@2|Bacteria,1MW57@1224|Proteobacteria,1SZIX@1236|Gammaproteobacteria,2Q5F3@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	AO	COG1404 Subtilisin-like serine proteases	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,Peptidase_S8
YHH3_k127_4975981_0	565033.GACE_1061	2.324e-47	188.0	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,2461Y@183980|Archaeoglobi	183980|Archaeoglobi	P	Chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
YHH3_k127_4989080_0	1197477.IA57_08470	4.018e-37	156.0	COG4249@1|root,COG4249@2|Bacteria,4PHQW@976|Bacteroidetes,1I5CW@117743|Flavobacteriia	976|Bacteroidetes	O	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_4989080_1	646529.Desaci_0681	4.025e-28	121.0	COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes	1239|Firmicutes	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
YHH3_k127_4989080_2	568703.LGG_01233	5.79e-19	95.0	COG0454@1|root,COG0456@2|Bacteria,1V7Z2@1239|Firmicutes,4HPF8@91061|Bacilli,3F7HG@33958|Lactobacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_4989262_0	1047013.AQSP01000144_gene915	8.724e-39	150.0	COG0492@1|root,COG0822@1|root,COG0492@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_oxidored,FeS_assembly_P,NifU_N,Pyr_redox_2,cNMP_binding
YHH3_k127_4989262_2	1387197.AWGA01000019_gene402	0.0001281	50.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
YHH3_k127_4989262_1	304371.MCP_1382	1.158e-23	102.0	COG2195@1|root,arCOG12582@2157|Archaea	2157|Archaea	E	tripeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5020848_5	1123288.SOV_4c03410	1.173e-09	62.0	COG0648@1|root,COG0648@2|Bacteria,1UZNN@1239|Firmicutes,4H20X@909932|Negativicutes	909932|Negativicutes	G	SMART AP endonuclease, family 2	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
YHH3_k127_5020848_3	342949.PNA2_1518	7.237e-24	116.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
YHH3_k127_5020848_1	572546.Arcpr_0045	1.804e-86	296.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
YHH3_k127_5020848_0	1183377.Py04_1371	7.518e-131	440.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,24339@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
YHH3_k127_5020848_2	192952.MM_0126	6.761e-61	227.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_5020848_4	1220534.B655_1647	7.188e-10	60.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,23NMP@183925|Methanobacteria	183925|Methanobacteria	L	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_5023210_0	112098.XP_008619334.1	1.237e-05	55.0	2C1KP@1|root,2RBK8@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5051712_0	926569.ANT_17050	3.97e-34	138.0	COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
YHH3_k127_5051712_1	387093.SUN_0100	3.613e-29	130.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42UBA@68525|delta/epsilon subdivisions,2YQIM@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glycos_transf_1
YHH3_k127_5051712_3	1227500.C494_15713	2.643e-06	60.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVVS@28890|Euryarchaeota,23UCY@183963|Halobacteria	183963|Halobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
YHH3_k127_5056321_0	604354.TSIB_0222	2.116e-74	262.0	COG1840@1|root,arCOG00221@2157|Archaea,2Y33A@28890|Euryarchaeota,243E5@183968|Thermococci	183968|Thermococci	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
YHH3_k127_5056321_3	195522.BD01_0698	4.552e-10	73.0	COG4945@1|root,arCOG01310@2157|Archaea,2Y7ME@28890|Euryarchaeota,243B5@183968|Thermococci	183968|Thermococci	G	to be involved in regulation of amylopullulanase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5056321_2	1151117.AJLF01000001_gene1134	3.745e-11	76.0	COG4945@1|root,arCOG01310@2157|Archaea,2Y7ME@28890|Euryarchaeota,243B5@183968|Thermococci	2157|Archaea	G	to be involved in regulation of amylopullulanase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C,PEGA
YHH3_k127_5056321_4	1449976.KALB_302	5.648e-06	60.0	COG0613@1|root,COG0613@2|Bacteria,2GNPF@201174|Actinobacteria,4E24R@85010|Pseudonocardiales	201174|Actinobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TAT_signal
YHH3_k127_5056321_1	717785.HYPMC_1063	7.115e-15	82.0	COG0389@1|root,COG0389@2|Bacteria,1NTDH@1224|Proteobacteria,2UNYG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332,Zn_dep_PLPC
YHH3_k127_5078503_4	1195236.CTER_2619	2.378e-11	66.0	COG0642@1|root,COG2205@2|Bacteria,1V2Z4@1239|Firmicutes,24GT8@186801|Clostridia	186801|Clostridia	T	Histidine kinase- DNA gyrase B	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
YHH3_k127_5078503_0	368408.Tpen_1350	2.876e-185	591.0	COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota	28889|Crenarchaeota	E	carboxypeptidase activity	-	-	-	ko:K12941,ko:K13048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
YHH3_k127_5078503_2	572544.Ilyop_0125	6.826e-63	221.0	COG0167@1|root,COG1145@1|root,COG0167@2|Bacteria,COG1145@2|Bacteria,37945@32066|Fusobacteria	32066|Fusobacteria	C	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4
YHH3_k127_5078503_3	490899.DKAM_0183	3.212e-46	171.0	COG0167@1|root,COG1148@1|root,arCOG00603@2157|Archaea,arCOG02235@2157|Archaea,2XQ06@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
YHH3_k127_5078503_1	177439.DP3059	2.143e-94	329.0	COG0038@1|root,COG0517@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,COG0569@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
YHH3_k127_5094558_1	797304.Natgr_1103	1.387e-77	274.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
YHH3_k127_5094558_0	574087.Acear_1157	9.559e-101	350.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,3WAAV@53433|Halanaerobiales	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
YHH3_k127_5095527_0	679926.Mpet_0909	9.576e-141	475.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAFK@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
YHH3_k127_5095527_2	1423321.AS29_05085	3.591e-28	131.0	COG3263@1|root,COG3263@2|Bacteria,1TQPJ@1239|Firmicutes,4HC8I@91061|Bacilli,1ZC6H@1386|Bacillus	91061|Bacilli	P	COG3263 NhaP-type Na H and K H antiporters with a unique C-terminal domain	cvrA	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
YHH3_k127_5095527_1	639282.DEFDS_1322	1.181e-89	313.0	COG3004@1|root,COG3004@2|Bacteria,2GGCA@200930|Deferribacteres	200930|Deferribacteres	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
YHH3_k127_5146261_0	386456.JQKN01000001_gene1914	2.817e-07	62.0	COG0642@1|root,arCOG02349@1|root,arCOG02350@1|root,arCOG02352@1|root,arCOG06712@1|root,arCOG02349@2157|Archaea,arCOG02350@2157|Archaea,arCOG02352@2157|Archaea,arCOG02358@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,HisKA_4TM,PAS,PAS_3,PAS_4,PAS_9
YHH3_k127_5161390_1	1151127.KB906325_gene5449	2.475e-10	72.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,1RNP5@1236|Gammaproteobacteria,1YSHS@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	EGP	MFS transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
YHH3_k127_5161390_0	1347368.HG964405_gene5957	1.722e-104	352.0	COG0006@1|root,COG0006@2|Bacteria,1UY7B@1239|Firmicutes,4HDTX@91061|Bacilli,1ZFAY@1386|Bacillus	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
YHH3_k127_5161390_2	1449353.JQMQ01000005_gene4727	3.124e-06	58.0	COG1522@1|root,COG1522@2|Bacteria,2GN6I@201174|Actinobacteria,2NI5Z@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
YHH3_k127_5172796_2	1120988.AXWV01000081_gene467	1.43e-31	124.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1Y475@135624|Aeromonadales	135624|Aeromonadales	P	Permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_5172796_1	351160.LRC379	8.64e-99	337.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,2N9GM@224756|Methanomicrobia	224756|Methanomicrobia	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
YHH3_k127_5172796_0	439481.Aboo_1252	7.042e-109	365.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,3F38V@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	oppD2	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
YHH3_k127_5174045_0	679897.HMU08480	5.293e-11	64.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2YMNY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
YHH3_k127_5174045_1	234831.PSM_A2865	9.963e-08	63.0	COG1522@1|root,COG1522@2|Bacteria,1MWPX@1224|Proteobacteria,1RRPA@1236|Gammaproteobacteria,2Q26H@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	COG1522 Transcriptional regulators	asnC	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016597,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031406,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043177,GO:0043200,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K03718,ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_5264372_1	272562.CA_C0702	2.378e-33	136.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,36EW8@31979|Clostridiaceae	186801|Clostridia	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
YHH3_k127_5264372_0	326427.Cagg_3176	5.317e-70	244.0	COG3845@1|root,COG3845@2|Bacteria,2G625@200795|Chloroflexi,374YV@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
YHH3_k127_5277989_2	765952.PUV_00410	0.0007936	44.0	COG1055@1|root,COG1055@2|Bacteria	2|Bacteria	P	arsenite transmembrane transporter activity	arsA	-	-	-	-	-	-	-	-	-	-	-	CitMHS
YHH3_k127_5277989_1	398512.JQKC01000015_gene4671	2.477e-35	147.0	COG1409@1|root,COG1409@2|Bacteria,1UA0Q@1239|Firmicutes,24VZZ@186801|Clostridia	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
YHH3_k127_5277989_0	386415.NT01CX_1206	2.661e-58	213.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36QTE@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_5350845_3	439235.Dalk_5067	6.346e-61	219.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MJQR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	heterodisulfide reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
YHH3_k127_5350845_4	237368.SCABRO_01879	5.206e-21	99.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
YHH3_k127_5350845_1	880073.Calab_3046	9.662e-256	817.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
YHH3_k127_5350845_2	391623.TERMP_00208	7.388e-231	730.0	COG1274@1|root,arCOG05865@2157|Archaea,2XUU1@28890|Euryarchaeota,24380@183968|Thermococci	183968|Thermococci	C	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
YHH3_k127_5350845_0	1232437.KL661978_gene3851	3.6e-275	864.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_5358995_0	192952.MM_1365	5.315e-20	96.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,2N9G5@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
YHH3_k127_5371481_1	580331.Thit_1015	2.355e-49	181.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,24JAK@186801|Clostridia,42G8F@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
YHH3_k127_5371481_0	555088.DealDRAFT_2538	1.048e-247	777.0	COG1960@1|root,COG1960@2|Bacteria,1V03D@1239|Firmicutes,24A8N@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
YHH3_k127_5371481_3	521000.PROVRETT_05691	0.0005504	49.0	294DM@1|root,2ZRTK@2|Bacteria,1PVMC@1224|Proteobacteria,1TE32@1236|Gammaproteobacteria,3ZA3I@586|Providencia	1236|Gammaproteobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4184
YHH3_k127_5371481_2	1348663.KCH_11630	0.0002601	52.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,2M2N0@2063|Kitasatospora	201174|Actinobacteria	K	helix_turn_helix ASNC type	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_5388095_1	67257.JODR01000003_gene1791	4.329e-07	61.0	COG0454@1|root,COG0456@2|Bacteria,2GMXI@201174|Actinobacteria	201174|Actinobacteria	K	Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_5388095_0	771875.Ferpe_1310	5.798e-76	262.0	COG0778@1|root,COG0778@2|Bacteria,2GCST@200918|Thermotogae	200918|Thermotogae	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH3_k127_540372_0	639030.JHVA01000001_gene1215	6.034e-71	252.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
YHH3_k127_540372_2	589924.Ferp_0979	7.859e-10	65.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,246C7@183980|Archaeoglobi	183980|Archaeoglobi	V	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
YHH3_k127_540372_1	6500.XP_005094721.1	5.077e-10	68.0	COG1100@1|root,KOG0070@2759|Eukaryota,38Q89@33154|Opisthokonta,3BDWZ@33208|Metazoa,3D0X0@33213|Bilateria	33208|Metazoa	U	alpha-tubulin binding	ARL4C	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008092,GO:0008150,GO:0015631,GO:0016020,GO:0016192,GO:0016197,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030175,GO:0032153,GO:0032154,GO:0032155,GO:0032456,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042995,GO:0043014,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0071944,GO:0097159,GO:0097367,GO:0098590,GO:0098858,GO:0120025,GO:1901265,GO:1901363	-	ko:K07945	-	-	-	-	ko00000,ko04031	-	-	-	Arf
YHH3_k127_54171_0	646529.Desaci_0681	6.097e-23	106.0	COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes	1239|Firmicutes	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
YHH3_k127_5423271_0	926569.ANT_29670	1.439e-46	172.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_5423271_1	1410668.JNKC01000001_gene1928	1.521e-20	104.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_5499605_0	1089553.Tph_c17120	1.22e-89	305.0	COG3535@1|root,COG3535@2|Bacteria,1TR39@1239|Firmicutes,24A65@186801|Clostridia,42FRV@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
YHH3_k127_550222_0	1365176.N186_07025	3.727e-15	79.0	COG1257@1|root,arCOG05512@2157|Archaea,2XSJX@28889|Crenarchaeota	28889|Crenarchaeota	I	hydroxymethylglutaryl-CoA reductase (NADPH) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_550222_1	69014.TK0025	6.094e-05	49.0	arCOG03777@1|root,arCOG03777@2157|Archaea,2Y692@28890|Euryarchaeota,243DI@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5506541_19	273068.TTE2402	3.508e-08	60.0	COG1131@1|root,COG1131@2|Bacteria,1TQEV@1239|Firmicutes,25B0Q@186801|Clostridia,42FQH@68295|Thermoanaerobacterales	186801|Clostridia	V	abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_5506541_6	523845.AQXV01000054_gene1535	1.191e-57	205.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,23QNU@183939|Methanococci	183939|Methanococci	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
YHH3_k127_5506541_9	1229909.NSED_03065	1.934e-47	180.0	COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
YHH3_k127_5506541_2	525904.Tter_0974	1.657e-87	306.0	COG0053@1|root,COG0053@2|Bacteria,2NPHA@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	MA20_15190	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
YHH3_k127_5506541_3	489825.LYNGBM3L_42320	1.714e-67	246.0	COG0436@1|root,COG0436@2|Bacteria,1G24E@1117|Cyanobacteria,1H6X1@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
YHH3_k127_5506541_1	1333523.L593_05760	3.276e-91	316.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,23SVV@183963|Halobacteria	183963|Halobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
YHH3_k127_5506541_5	368408.Tpen_0138	9.671e-62	222.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
YHH3_k127_5506541_17	930945.SiRe_0233	2.72e-09	64.0	COG4352@1|root,arCOG01013@2157|Archaea,2XRIE@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL13 family	rpl13e	-	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e,Ribosomal_L15e
YHH3_k127_5506541_21	180332.JTGN01000005_gene2896	1.974e-05	56.0	COG0524@1|root,COG0524@2|Bacteria,1V4QY@1239|Firmicutes,24HRA@186801|Clostridia	186801|Clostridia	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
YHH3_k127_5506541_22	13037.EHJ79074	0.0005911	49.0	KOG3330@1|root,KOG3330@2759|Eukaryota,38BCP@33154|Opisthokonta,3BC4V@33208|Metazoa,3D04K@33213|Bilateria,41YMR@6656|Arthropoda,3SKZQ@50557|Insecta,441JS@7088|Lepidoptera	33208|Metazoa	U	May play a role in vesicular transport from endoplasmic reticulum to Golgi	TRAPPC3	GO:0000139,GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005829,GO:0006403,GO:0006810,GO:0006888,GO:0006891,GO:0007275,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0012505,GO:0015031,GO:0015833,GO:0015931,GO:0016020,GO:0016192,GO:0018996,GO:0030008,GO:0031090,GO:0031984,GO:0032501,GO:0032502,GO:0032940,GO:0032991,GO:0033036,GO:0033227,GO:0035264,GO:0040002,GO:0040007,GO:0042303,GO:0042335,GO:0042338,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0048193,GO:0048589,GO:0048856,GO:0050657,GO:0050658,GO:0051179,GO:0051234,GO:0051236,GO:0051641,GO:0051649,GO:0071702,GO:0071705,GO:0098588,GO:0098791,GO:0099023	-	ko:K20302	-	-	-	-	ko00000,ko04131	-	-	-	TRAPP
YHH3_k127_5506541_15	644281.MFS40622_1163	9.301e-13	78.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
YHH3_k127_5506541_8	579137.Metvu_1137	3.025e-53	196.0	COG1136@1|root,arCOG00922@2157|Archaea,2XV0G@28890|Euryarchaeota,23QFT@183939|Methanococci	183939|Methanococci	E	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_5506541_20	1123277.KB893172_gene962	8.143e-08	65.0	COG0577@1|root,COG0577@2|Bacteria,4P3C0@976|Bacteroidetes	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
YHH3_k127_5506541_0	644281.MFS40622_0309	4.879e-101	349.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,23Q0A@183939|Methanococci	183939|Methanococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
YHH3_k127_5506541_10	1521187.JPIM01000023_gene768	2.58e-31	132.0	COG0558@1|root,COG0558@2|Bacteria,2GAQW@200795|Chloroflexi,3773G@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
YHH3_k127_5506541_18	1280681.AUJZ01000005_gene3102	1.23e-08	66.0	COG0524@1|root,COG0524@2|Bacteria,1UYF8@1239|Firmicutes,25MKS@186801|Clostridia,4BVZA@830|Butyrivibrio	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
YHH3_k127_5506541_11	195522.BD01_2200	4.27e-24	105.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y6ET@28890|Euryarchaeota,244B9@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
YHH3_k127_5506541_14	1094980.Mpsy_2777	1.653e-18	93.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
YHH3_k127_5506541_13	1131266.ARWQ01000002_gene479	5.453e-21	95.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
YHH3_k127_5506541_4	370438.PTH_2033	3.543e-63	230.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,24AAC@186801|Clostridia,260MS@186807|Peptococcaceae	186801|Clostridia	BQ	histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
YHH3_k127_5506541_12	362976.HQ_1438A	4.115e-21	108.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23SC2@183963|Halobacteria	183963|Halobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
YHH3_k127_5506541_16	1120971.AUCA01000025_gene770	1.837e-09	65.0	COG1051@1|root,COG1051@2|Bacteria,1UWQJ@1239|Firmicutes,4IFRF@91061|Bacilli,27AGX@186823|Alicyclobacillaceae	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
YHH3_k127_5506541_7	386456.JQKN01000002_gene2721	3.882e-57	211.0	COG2248@1|root,arCOG00969@2157|Archaea,2XW12@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B_2,Lactamase_B_3
YHH3_k127_5526527_0	760568.Desku_1207	6.146e-200	632.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,260X7@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM methylmalonyl-CoA mutase N-terminal domain	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
YHH3_k127_5541715_6	868864.Dester_1194	0.0006633	48.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_5541715_2	565033.GACE_1595	2.171e-34	140.0	COG1189@1|root,arCOG00080@2157|Archaea,2XXP2@28890|Euryarchaeota,2467W@183980|Archaeoglobi	183980|Archaeoglobi	Q	Ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
YHH3_k127_5541715_1	604354.TSIB_1375	6.509e-36	147.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
YHH3_k127_5541715_3	195522.BD01_1951	4.276e-34	137.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2438P@183968|Thermococci	183968|Thermococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
YHH3_k127_5541715_5	1183377.Py04_0694	1.396e-15	85.0	COG1813@1|root,arCOG01863@2157|Archaea,2XWZV@28890|Euryarchaeota,242VJ@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
YHH3_k127_5541715_0	224325.AF_1976	3.057e-133	437.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
YHH3_k127_5541715_4	195522.BD01_0979	6.484e-24	107.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,243G1@183968|Thermococci	183968|Thermococci	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
YHH3_k127_5551184_0	926569.ANT_04650	1.286e-215	678.0	COG0031@1|root,COG0031@2|Bacteria,2G8GE@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
YHH3_k127_5570897_2	269797.Mbar_A1255	4.874e-22	104.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
YHH3_k127_5570897_1	420247.Msm_1010	2.534e-44	169.0	COG4063@1|root,arCOG03221@2157|Archaea,2XWSE@28890|Euryarchaeota,23PC8@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrA	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
YHH3_k127_5570897_0	868131.MSWAN_2048	8.592e-65	229.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
YHH3_k127_5577482_0	266117.Rxyl_2848	1.814e-120	395.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4CQAT@84995|Rubrobacteria	84995|Rubrobacteria	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
YHH3_k127_5577482_1	1047013.AQSP01000055_gene265	5.885e-46	168.0	COG0251@1|root,COG0251@2|Bacteria,2NPSA@2323|unclassified Bacteria	2|Bacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
YHH3_k127_559871_0	693661.Arcve_1597	3.218e-27	114.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,246PH@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
YHH3_k127_5634231_0	696369.KI912183_gene752	1.528e-78	272.0	COG0327@1|root,COG0327@2|Bacteria,1UK7Y@1239|Firmicutes,248IP@186801|Clostridia,260W5@186807|Peptococcaceae	186801|Clostridia	S	PFAM NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5634231_3	1267005.KB911257_gene1051	8.134e-21	102.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria,3N86N@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5634231_1	1121897.AUGO01000004_gene1033	2.321e-45	177.0	COG0111@1|root,COG0111@2|Bacteria,4NE9J@976|Bacteroidetes	976|Bacteroidetes	EH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase	ghrA	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
YHH3_k127_5634231_2	926561.KB900618_gene59	9.91e-24	110.0	COG2211@1|root,COG2211@2|Bacteria,1UI2Y@1239|Firmicutes,25EBU@186801|Clostridia,3WB25@53433|Halanaerobiales	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_5643613_0	572478.Vdis_1210	0.0	1108.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
YHH3_k127_5643776_0	1220534.B655_2207	4.873e-81	280.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	nosF1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH3_k127_5643776_1	1220534.B655_2206	6.557e-54	198.0	COG0842@1|root,arCOG01463@2157|Archaea,2XX4N@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
YHH3_k127_5655175_1	877455.Metbo_1297	4.562e-05	54.0	COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota,23PDF@183925|Methanobacteria	183925|Methanobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
YHH3_k127_5655175_0	1346791.M529_17405	4.983e-18	94.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
YHH3_k127_5669_0	192952.MM_0848	5.339e-38	153.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y29P@28890|Euryarchaeota,2NA5X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5669_1	1479237.JMLY01000001_gene1593	1.097e-33	145.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,4644Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
YHH3_k127_5720300_0	339860.Msp_0854	2.732e-48	186.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23NK4@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
YHH3_k127_5720300_1	368407.Memar_1711	4.168e-17	86.0	COG0644@1|root,arCOG00570@2157|Archaea,2XWXQ@28890|Euryarchaeota,2N9RD@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
YHH3_k127_5731895_1	706587.Desti_3979	4.503e-49	183.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15560	OMPdecase,Pribosyltran
YHH3_k127_5731895_6	1220534.B655_1002	3.275e-13	83.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
YHH3_k127_5731895_3	1142394.PSMK_30150	2.148e-32	139.0	COG2159@1|root,COG2159@2|Bacteria,2IYMW@203682|Planctomycetes	203682|Planctomycetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
YHH3_k127_5731895_5	1280692.AUJL01000017_gene1032	1.133e-21	101.0	COG0655@1|root,COG0655@2|Bacteria,1V26K@1239|Firmicutes,24IAS@186801|Clostridia,36VWE@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_5731895_4	439235.Dalk_1327	4.053e-24	112.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
YHH3_k127_5731895_2	932678.THERU_02370	3.386e-38	147.0	COG0394@1|root,COG0394@2|Bacteria,2G51E@200783|Aquificae	200783|Aquificae	T	low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
YHH3_k127_5731895_0	1229909.NSED_07320	1.44e-108	377.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
YHH3_k127_5731895_7	485915.Dret_1567	4.476e-05	52.0	COG0457@1|root,COG2885@1|root,COG0457@2|Bacteria,COG2885@2|Bacteria,1MYZU@1224|Proteobacteria,42SNQ@68525|delta/epsilon subdivisions,2WPHI@28221|Deltaproteobacteria,2M842@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
YHH3_k127_5773531_1	1183438.GKIL_0223	1.084e-39	155.0	COG0122@1|root,COG0122@2|Bacteria,1G394@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM HhH-GPD superfamily base excision DNA repair protein	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
YHH3_k127_5773531_0	1121405.dsmv_3718	9.379e-82	284.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,42UJZ@68525|delta/epsilon subdivisions,2WQCC@28221|Deltaproteobacteria,2MKGV@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Adenosine/AMP deaminase	-	-	3.5.4.2,3.5.4.4	ko:K01488,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01244,R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
YHH3_k127_5773531_4	768706.Desor_1979	1.122e-05	57.0	COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,24I1I@186801|Clostridia,265TE@186807|Peptococcaceae	186801|Clostridia	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_5773531_2	502025.Hoch_5114	7.214e-25	108.0	28XBK@1|root,2ZJ9G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_5818767_1	313603.FB2170_10111	1.221e-33	143.0	COG3055@1|root,COG3204@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3204@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HWPE@117743|Flavobacteriia,2PGXB@252356|Maribacter	976|Bacteroidetes	M	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_6,Malectin,PKD
YHH3_k127_5818767_4	555088.DealDRAFT_2721	4.891e-06	58.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,42KR6@68298|Syntrophomonadaceae	186801|Clostridia	O	Belongs to the peptidase S8 family	isp	-	3.4.21.62	ko:K01342,ko:K13275	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,Peptidase_S8
YHH3_k127_5818767_0	673860.AciM339_0352	9.773e-101	340.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,3F37E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
YHH3_k127_5818767_3	1450694.BTS2_0055	7.795e-08	61.0	COG0526@1|root,COG0526@2|Bacteria,1V2DU@1239|Firmicutes,4HGQZ@91061|Bacilli,1ZG9D@1386|Bacillus	91061|Bacilli	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_9
YHH3_k127_5818767_2	572478.Vdis_1294	3.598e-12	76.0	COG2219@1|root,arCOG03013@2157|Archaea,2XQ8M@28889|Crenarchaeota	28889|Crenarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
YHH3_k127_584598_1	517418.Ctha_0236	1.825e-18	99.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	cspBA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_584598_0	935837.JAEK01000012_gene315	4.174e-123	403.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4HATT@91061|Bacilli,1ZB9N@1386|Bacillus	91061|Bacilli	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
YHH3_k127_584957_0	1209989.TepiRe1_1537	1.612e-141	481.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
YHH3_k127_584957_2	463191.SSEG_07800	1.041e-25	124.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_584957_3	662479.C440_13434	9.741e-19	99.0	COG0477@1|root,arCOG00134@2157|Archaea,2Y8EP@28890|Euryarchaeota,2419U@183963|Halobacteria	183963|Halobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_584957_1	635013.TherJR_1575	4.171e-52	193.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,26325@186807|Peptococcaceae	186801|Clostridia	E	histidinol phosphate phosphatase	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
YHH3_k127_5850056_2	351160.RCIX2409	6.946e-127	419.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
YHH3_k127_5850056_3	935948.KE386495_gene1235	3.318e-100	339.0	COG0438@1|root,COG0438@2|Bacteria,1TQRQ@1239|Firmicutes,249H2@186801|Clostridia,42EVC@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
YHH3_k127_5850056_5	385682.AFSL01000083_gene1143	1.068e-78	275.0	COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes,2FMEB@200643|Bacteroidia,3XJ81@558415|Marinilabiliaceae	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
YHH3_k127_5850056_4	1150474.JQJI01000007_gene253	1.257e-82	284.0	COG2152@1|root,COG2152@2|Bacteria,2GCDD@200918|Thermotogae	200918|Thermotogae	G	PFAM glycosidase, PH1107-related	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
YHH3_k127_5850056_9	999630.TUZN_0897	3.033e-22	100.0	COG0517@1|root,arCOG00606@2157|Archaea,2XQQK@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
YHH3_k127_5850056_7	1499967.BAYZ01000038_gene2266	1.161e-68	240.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
YHH3_k127_5850056_0	1121912.AUHD01000004_gene2114	7.917e-189	595.0	COG0438@1|root,COG0438@2|Bacteria,4NKIM@976|Bacteroidetes,1I06P@117743|Flavobacteriia	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
YHH3_k127_5850056_1	1499967.BAYZ01000038_gene2268	2.136e-163	523.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF608,GDE_C,Glyco_hydro_100,S6PP
YHH3_k127_5850056_11	525897.Dbac_2305	2.884e-08	63.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,42PGP@68525|delta/epsilon subdivisions,2WMGP@28221|Deltaproteobacteria,2M84A@213115|Desulfovibrionales	28221|Deltaproteobacteria	KQ	PFAM Methyltransferase type 11	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5,Methyltransf_11
YHH3_k127_5850056_6	1444711.CCJF01000005_gene546	5.784e-78	282.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
YHH3_k127_5850056_10	1460635.JCM19038_1390	3.221e-15	81.0	COG0633@1|root,COG0633@2|Bacteria,1VAB4@1239|Firmicutes,4HM5K@91061|Bacilli	91061|Bacilli	C	2Fe-2S iron-sulfur cluster binding domain	fdx5	-	-	-	-	-	-	-	-	-	-	-	Fer2
YHH3_k127_5850056_12	1117319.PSPO_09749	0.000105	55.0	COG0823@1|root,COG0823@2|Bacteria,1RCAF@1224|Proteobacteria,1S32R@1236|Gammaproteobacteria,2Q3XY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	U	Domain of unknown function (DUF5050)	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
YHH3_k127_5850056_8	1122927.KB895417_gene2953	5.552e-50	194.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli,26RUX@186822|Paenibacillaceae	91061|Bacilli	P	Arsenical pump membrane protein	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	CitMHS
YHH3_k127_590626_0	398527.Bphyt_3670	2.304e-05	55.0	COG1522@1|root,COG1522@2|Bacteria,1REAJ@1224|Proteobacteria,2VRWP@28216|Betaproteobacteria,1K307@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	-	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
YHH3_k127_5910918_2	161156.JQKW01000012_gene22	2.32e-07	53.0	COG0125@1|root,COG1618@1|root,COG0125@2|Bacteria,COG1618@2|Bacteria,2GHI1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTPase_1,Thymidylate_kin
YHH3_k127_5910918_3	1145276.T479_10745	0.0001474	50.0	COG1657@1|root,COG1657@2|Bacteria,1VBUR@1239|Firmicutes,4HHJY@91061|Bacilli	91061|Bacilli	I	Domain of unknown function (DUF4430)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4430
YHH3_k127_5910918_4	643648.Slip_0332	0.0004487	49.0	COG4720@1|root,COG4720@2|Bacteria,1V2DR@1239|Firmicutes,249XR@186801|Clostridia,42KMD@68298|Syntrophomonadaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF-ribofla_trS,ECF_trnsprt
YHH3_k127_5910918_0	69014.TK2277	4.841e-12	74.0	arCOG02103@1|root,arCOG02103@2157|Archaea,2Y0TZ@28890|Euryarchaeota,243RM@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
YHH3_k127_5910918_1	926690.KE386573_gene2809	1.626e-10	70.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,23S0J@183963|Halobacteria	183963|Halobacteria	L	COG1111 ERCC4-like helicases	hef	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
YHH3_k127_59494_16	70601.3257822	9.558e-31	130.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,242X3@183968|Thermococci	183968|Thermococci	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
YHH3_k127_59494_12	272844.PAB0284	3.031e-35	142.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
YHH3_k127_59494_9	529709.PYCH_00940	9.215e-44	172.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,242SR@183968|Thermococci	183968|Thermococci	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
YHH3_k127_59494_10	589924.Ferp_0274	9.764e-43	163.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,246VN@183980|Archaeoglobi	183980|Archaeoglobi	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
YHH3_k127_59494_24	397948.Cmaq_1982	9.256e-08	58.0	COG1460@1|root,arCOG01016@2157|Archaea,2XRD2@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
YHH3_k127_59494_17	591019.Shell_0022	2.701e-27	113.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
YHH3_k127_59494_4	243232.MJ_0041	4.667e-87	305.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,23QN9@183939|Methanococci	183939|Methanococci	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
YHH3_k127_59494_8	1094980.Mpsy_1026	7.948e-49	190.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
YHH3_k127_59494_13	70601.3257966	2.234e-34	136.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
YHH3_k127_59494_7	572478.Vdis_2231	2.383e-61	228.0	COG0585@1|root,arCOG04252@2157|Archaea,2XQXM@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
YHH3_k127_59494_19	1184251.TCELL_0559	8.908e-16	85.0	COG0195@1|root,arCOG01761@2157|Archaea,2XQP0@28889|Crenarchaeota	28889|Crenarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_59494_18	387631.Asulf_00780	8.414e-21	95.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,246D0@183980|Archaeoglobi	183980|Archaeoglobi	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
YHH3_k127_59494_3	1131266.ARWQ01000001_gene1211	1.657e-93	321.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
YHH3_k127_59494_21	272557.APE_0179a	2.039e-10	64.0	arCOG04057@1|root,arCOG04057@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL38 family	rpl38e	-	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
YHH3_k127_59494_23	1056495.Calag_1474	2.486e-08	56.0	COG1552@1|root,arCOG04049@2157|Archaea,2XRHJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
YHH3_k127_59494_2	415426.Hbut_0202	3.285e-103	342.0	COG0074@1|root,arCOG01339@2157|Archaea,2XPW3@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
YHH3_k127_59494_1	386456.JQKN01000001_gene2243	2.517e-108	362.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,23NSU@183925|Methanobacteria	183925|Methanobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
YHH3_k127_59494_25	2903.EOD12464	0.0001027	55.0	COG1204@1|root,KOG0951@2759|Eukaryota	2759|Eukaryota	B	helicase activity	SNRNP200	GO:0000003,GO:0000245,GO:0000354,GO:0000375,GO:0000377,GO:0000388,GO:0000393,GO:0000398,GO:0003006,GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005730,GO:0005737,GO:0005829,GO:0005911,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0007275,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0008380,GO:0009506,GO:0009791,GO:0009987,GO:0010228,GO:0010467,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022414,GO:0022607,GO:0022613,GO:0022618,GO:0030054,GO:0030532,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032991,GO:0034622,GO:0034641,GO:0042623,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045292,GO:0046483,GO:0046540,GO:0048608,GO:0048731,GO:0048856,GO:0055044,GO:0061458,GO:0065003,GO:0070013,GO:0070035,GO:0071013,GO:0071014,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097525,GO:0097526,GO:0120114,GO:0140098,GO:1901360,GO:1902494,GO:1990904	3.6.4.13	ko:K12854	ko03040,map03040	M00354,M00355	-	-	ko00000,ko00001,ko00002,ko01000,ko03041	-	-	-	DEAD,Helicase_C,Sec63
YHH3_k127_59494_15	1365176.N186_02805	8.822e-31	130.0	COG1938@1|root,arCOG00347@2157|Archaea,2XPV9@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
YHH3_k127_59494_22	387631.Asulf_02003	5.486e-09	64.0	COG1374@1|root,arCOG00993@2157|Archaea,2Y0D1@28890|Euryarchaeota,2474B@183980|Archaeoglobi	183980|Archaeoglobi	J	PUA domain	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
YHH3_k127_59494_5	273063.STK_02990	4.036e-80	278.0	COG0144@1|root,arCOG00973@2157|Archaea,2XQ6R@28889|Crenarchaeota	28889|Crenarchaeota	J	NOL1 NOP2 sun family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
YHH3_k127_59494_6	572480.Arnit_2107	1.324e-68	235.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria,42RF7@68525|delta/epsilon subdivisions,2YP03@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	FJ	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
YHH3_k127_59494_0	633148.Tagg_0552	7.407e-113	377.0	COG0498@1|root,arCOG01434@2157|Archaea,2XQ1A@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
YHH3_k127_59494_14	1227487.C474_02231	6.228e-32	135.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,23VIW@183963|Halobacteria	183963|Halobacteria	F	COG1437 Adenylate cyclase, class 2 (thermophilic)	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
YHH3_k127_59494_11	593750.Metfor_1983	2.224e-36	145.0	COG1418@1|root,arCOG01860@2157|Archaea,2XSXG@28890|Euryarchaeota,2NA06@224756|Methanomicrobia	224756|Methanomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
YHH3_k127_59494_20	1238184.CM001792_gene763	1.754e-13	85.0	COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,4HB2E@91061|Bacilli,23JFQ@182709|Oceanobacillus	91061|Bacilli	E	Transglutaminase/protease-like homologues	yebA	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
YHH3_k127_5952755_0	368408.Tpen_0043	7.615e-61	220.0	COG1530@1|root,arCOG00321@2157|Archaea,2XQ2D@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_5952755_1	529709.PYCH_03760	7.562e-41	168.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,242W4@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_5952755_2	1396.DJ87_2024	2.112e-35	145.0	COG0454@1|root,COG0456@2|Bacteria,1UHRF@1239|Firmicutes,4IS7A@91061|Bacilli,1ZMHX@1386|Bacillus	91061|Bacilli	K	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
YHH3_k127_59590_0	1459636.NTE_01027	5.776e-51	198.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
YHH3_k127_5960797_4	439235.Dalk_2102	4.447e-53	193.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
YHH3_k127_5960797_7	1444309.JAQG01000157_gene3286	1.244e-14	83.0	COG1011@1|root,COG1011@2|Bacteria,1V3WC@1239|Firmicutes,4IPNC@91061|Bacilli,2760Q@186822|Paenibacillaceae	91061|Bacilli	S	HAD-hyrolase-like	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
YHH3_k127_5960797_9	1535287.JP74_15455	7.615e-07	54.0	COG0457@1|root,COG0457@2|Bacteria,1PQD2@1224|Proteobacteria,2U31T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	o-linked GlcNac transferase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_17,TPR_19,TPR_2,TPR_4,TPR_8
YHH3_k127_5960797_8	604354.TSIB_1095	2.256e-10	72.0	COG2512@1|root,arCOG00374@2157|Archaea	2157|Archaea	T	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2
YHH3_k127_5960797_1	102232.GLO73106DRAFT_00021270	6.57e-96	327.0	COG0675@1|root,COG0675@2|Bacteria,1G2YM@1117|Cyanobacteria	1117|Cyanobacteria	L	TIGRFAM transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_5960797_3	555079.Toce_1199	1.439e-59	208.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,42G8Z@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
YHH3_k127_5960797_2	1009370.ALO_15362	5.424e-94	318.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,4H1WI@909932|Negativicutes	909932|Negativicutes	E	LAO AO transport system	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
YHH3_k127_5960797_0	1304284.L21TH_0800	2.821e-263	820.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,36H9W@31979|Clostridiaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
YHH3_k127_5960797_5	243231.GSU3303	1.845e-49	179.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,43URU@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
YHH3_k127_5960797_6	555079.Toce_0664	5.438e-26	111.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,25J0X@186801|Clostridia,42F6Z@68295|Thermoanaerobacterales	186801|Clostridia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
YHH3_k127_5970177_1	227086.JGI_V11_71630	3.848e-34	135.0	COG0339@1|root,KOG2089@2759|Eukaryota	2759|Eukaryota	E	metalloendopeptidase activity	PRD1	GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005773,GO:0005794,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0012505,GO:0016787,GO:0019538,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0034641,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070011,GO:0070013,GO:0071704,GO:0140096,GO:1901564	3.4.24.15,3.4.24.37	ko:K01392,ko:K01405,ko:K13726	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
YHH3_k127_5970177_3	673860.AciM339_0522	4.479e-06	59.0	arCOG02499@1|root,arCOG02550@1|root,arCOG02499@2157|Archaea,arCOG02550@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD,Pkinase
YHH3_k127_5970177_0	1104324.P186_2190	3.55e-124	410.0	COG1812@1|root,arCOG01678@2157|Archaea,2XPSB@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
YHH3_k127_5970177_2	69014.TK1266	1.551e-27	119.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,242XH@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
YHH3_k127_5970177_4	225400.XP_006754347.1	1.136e-05	58.0	COG0749@1|root,COG4581@1|root,KOG0949@2759|Eukaryota,KOG0950@2759|Eukaryota,38FA1@33154|Opisthokonta,3BAQM@33208|Metazoa,3CU37@33213|Bilateria,488C4@7711|Chordata,495TB@7742|Vertebrata,3JC8G@40674|Mammalia	33208|Metazoa	A	ATP-dependent RNA helicase	DDX60	-	3.6.4.13	ko:K20103	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	DEAD,Helicase_C
YHH3_k127_6001402_1	272563.CD630_13970	1.859e-27	117.0	COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,247X5@186801|Clostridia	186801|Clostridia	Q	Methyltransferase, YaeB	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
YHH3_k127_6001402_0	1121335.Clst_0273	4.451e-34	137.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,3WJ94@541000|Ruminococcaceae	186801|Clostridia	I	thioesterase	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
YHH3_k127_6015807_1	1457393.AZ09_02760	0.0002532	48.0	COG0747@1|root,COG0747@2|Bacteria,1N4WS@1224|Proteobacteria,2UEVG@28211|Alphaproteobacteria,2JZH5@204441|Rhodospirillales	204441|Rhodospirillales	E	transporter substrate-binding	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_6020088_3	387631.Asulf_00805	1.078e-58	213.0	COG1205@1|root,arCOG00555@2157|Archaea,2XTPR@28890|Euryarchaeota,245V4@183980|Archaeoglobi	183980|Archaeoglobi	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
YHH3_k127_6020088_2	1094980.Mpsy_1799	2.202e-69	259.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
YHH3_k127_6020088_1	1094980.Mpsy_1386	1.9e-78	274.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
YHH3_k127_6020088_6	192952.MM_0291	3.735e-10	64.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,2NB8N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6020088_5	1283299.AUKG01000003_gene597	1.482e-10	70.0	COG2220@1|root,COG2220@2|Bacteria,2HP2V@201174|Actinobacteria,4CQDX@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
YHH3_k127_6020088_0	1095769.CAHF01000005_gene1567	1.206e-114	391.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853,DUF87,PLDc_2
YHH3_k127_6020088_4	368407.Memar_1616	2.566e-15	89.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,2NA2J@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
YHH3_k127_6020088_8	180332.JTGN01000002_gene5535	0.0001565	52.0	COG4717@1|root,COG4717@2|Bacteria,1TQP3@1239|Firmicutes,24E0A@186801|Clostridia	186801|Clostridia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
YHH3_k127_6021772_0	6500.XP_005095921.1	2.041e-14	79.0	KOG3339@1|root,KOG3339@2759|Eukaryota,38Z55@33154|Opisthokonta,3BF7Q@33208|Metazoa,3D2TU@33213|Bilateria	33208|Metazoa	S	dolichol-linked oligosaccharide biosynthetic process	ALG14	GO:0003674,GO:0003824,GO:0004577,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006488,GO:0006490,GO:0006629,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0023052,GO:0030154,GO:0031984,GO:0032502,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045165,GO:0045168,GO:0046331,GO:0048869,GO:0070085,GO:0071704,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.141	ko:K07441	ko00510,ko00513,ko01100,map00510,map00513,map01100	M00055	R05970	-	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT1	-	Alg14
YHH3_k127_6021772_1	28229.ND2E_1885	4.329e-14	74.0	COG5017@1|root,COG5017@2|Bacteria	2|Bacteria	T	Glycosyltransferase family 28 C-terminal domain	pssE	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
YHH3_k127_6080043_0	1128398.Curi_c06920	3.927e-44	169.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,268N0@186813|unclassified Clostridiales	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
YHH3_k127_6106793_0	574087.Acear_1487	1.001e-141	471.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_6106793_2	529709.PYCH_10450	4.771e-07	55.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y1MB@28890|Euryarchaeota,244GZ@183968|Thermococci	183968|Thermococci	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
YHH3_k127_6106793_1	443143.GM18_3240	8.797e-47	179.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	hdrG	-	-	-	-	-	-	-	-	-	-	-	FlpD
YHH3_k127_611485_2	1444310.JANV01000162_gene1198	0.0002916	46.0	2DC6Z@1|root,2ZD43@2|Bacteria	2|Bacteria	S	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3
YHH3_k127_611485_0	1499967.BAYZ01000050_gene2845	1.758e-70	251.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
YHH3_k127_611485_1	868131.MSWAN_0527	3.81e-36	146.0	COG0164@1|root,arCOG04121@2157|Archaea,2XZEX@28890|Euryarchaeota,23PK4@183925|Methanobacteria	183925|Methanobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
YHH3_k127_6116298_0	38033.XP_001227683.1	2.09e-37	153.0	COG0666@1|root,KOG0504@2759|Eukaryota,39YNX@33154|Opisthokonta,3P0DM@4751|Fungi,3QV70@4890|Ascomycota,21R8P@147550|Sordariomycetes,3UF4S@5139|Sordariales,3HG1D@35718|Chaetomiaceae	4751|Fungi	S	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5,NACHT,PNP_UDP_1
YHH3_k127_613639_1	1335760.ASTG01000010_gene616	5.589e-08	60.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2K0VP@204457|Sphingomonadales	204457|Sphingomonadales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_613639_0	1123288.SOV_7c00310	3.146e-31	134.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,4H3AP@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
YHH3_k127_6154759_0	456442.Mboo_1215	1.878e-06	59.0	arCOG12694@1|root,arCOG12694@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6183711_0	589873.EP13_18235	3.228e-63	240.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,46466@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	arginine decarboxylase	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283	Orn_Arg_deC_N
YHH3_k127_6183711_1	760568.Desku_3256	0.0004768	49.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261EY@186807|Peptococcaceae	186801|Clostridia	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
YHH3_k127_6185522_0	1232410.KI421419_gene2488	1.356e-07	58.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,43S56@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
YHH3_k127_6204552_3	456442.Mboo_2377	2.418e-06	57.0	COG0747@1|root,arCOG01534@2157|Archaea	2157|Archaea	E	ABC-type dipeptide transport system periplasmic component	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_6204552_2	426117.M446_0671	1.657e-13	84.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,1JUDI@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM extracellular solute-binding protein family 5	MA20_19540	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_6204552_4	1150474.JQJI01000002_gene1196	1.441e-05	58.0	COG0747@1|root,COG0747@2|Bacteria,2GC1T@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
YHH3_k127_6204552_0	573061.Clocel_2976	1.031e-73	257.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
YHH3_k127_6204552_1	555088.DealDRAFT_1098	1.006e-31	130.0	COG0491@1|root,COG0491@2|Bacteria,1V62I@1239|Firmicutes,24I5E@186801|Clostridia,42JY1@68298|Syntrophomonadaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_621550_0	1116369.KB890024_gene3267	1.341e-15	86.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,43HQI@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase	envZ	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
YHH3_k127_6216363_1	374847.Kcr_0092	7.802e-101	337.0	COG1167@1|root,arCOG00492@2157|Archaea	2157|Archaea	EK	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
YHH3_k127_6216363_6	1347087.CBYO010000011_gene1710	2.666e-11	76.0	COG4365@1|root,COG4365@2|Bacteria,1TQ2P@1239|Firmicutes,4HA2Z@91061|Bacilli	91061|Bacilli	S	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
YHH3_k127_6216363_2	1313301.AUGC01000001_gene1509	2.309e-78	281.0	COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes	976|Bacteroidetes	M	N-acetyl-alpha-D-glucosaminyl L-malate synthase	bshA	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
YHH3_k127_6216363_5	203119.Cthe_2223	1.915e-13	79.0	COG2120@1|root,COG2120@2|Bacteria,1UZDV@1239|Firmicutes,24FCK@186801|Clostridia,3WPET@541000|Ruminococcaceae	186801|Clostridia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
YHH3_k127_6216363_0	439481.Aboo_1538	2.385e-105	358.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,3F2G6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmm4	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
YHH3_k127_6216363_4	871968.DESME_01970	5.575e-26	117.0	COG2267@1|root,COG2267@2|Bacteria,1V4GY@1239|Firmicutes,25EJZ@186801|Clostridia,261ST@186807|Peptococcaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
YHH3_k127_6216363_3	110365.A0A023B838	2.711e-39	153.0	COG1100@1|root,KOG0098@2759|Eukaryota,3Y9NR@5794|Apicomplexa	5794|Apicomplexa	U	Rab2, GTPase	-	GO:0000139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0008150,GO:0012505,GO:0016020,GO:0017157,GO:0031090,GO:0031984,GO:0032879,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045921,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0060627,GO:0065007,GO:0098588,GO:0098791,GO:1903530,GO:1903532	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_6224535_0	485916.Dtox_2125	5.627e-117	387.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,260PA@186807|Peptococcaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
YHH3_k127_6241413_0	439235.Dalk_0164	3.514e-119	394.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
YHH3_k127_6241413_1	439235.Dalk_0163	3.98e-82	284.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
YHH3_k127_6280563_0	671065.MetMK1DRAFT_00030780	1.795e-10	66.0	arCOG05900@1|root,arCOG05900@2157|Archaea,2XRDZ@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
YHH3_k127_6305936_0	351160.LRC377	6.207e-63	243.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_6305936_1	384616.Pisl_1029	3.419e-62	222.0	COG1171@1|root,arCOG01431@2157|Archaea,2XPZF@28889|Crenarchaeota	28889|Crenarchaeota	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
YHH3_k127_6309870_0	429009.Adeg_1700	5.484e-223	711.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
YHH3_k127_6309870_1	694429.Pyrfu_1593	3.369e-12	68.0	COG3609@1|root,arCOG01009@2157|Archaea,2XR62@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
YHH3_k127_6311119_0	935836.JAEL01000022_gene1658	5.138e-94	320.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HAM3@91061|Bacilli,1ZD31@1386|Bacillus	91061|Bacilli	E	Threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
YHH3_k127_6311119_1	351160.RCIX86	1.713e-61	228.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_6311119_5	1452535.JARD01000005_gene3446	0.0009954	50.0	COG4927@1|root,COG4927@2|Bacteria,2I9GM@201174|Actinobacteria,4FQZ3@85023|Microbacteriaceae	201174|Actinobacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
YHH3_k127_6311119_2	748449.Halha_0139	2.896e-43	168.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,3WAXE@53433|Halanaerobiales	186801|Clostridia	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
YHH3_k127_6311119_3	243275.TDE_2514	3.065e-08	64.0	COG2129@1|root,COG2129@2|Bacteria,2J78J@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG2129 phosphoesterase related to the Icc protein	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos_2
YHH3_k127_6315529_2	1463885.KL578430_gene6947	2.672e-08	55.0	COG1670@1|root,COG1670@2|Bacteria,2HE22@201174|Actinobacteria	201174|Actinobacteria	J	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
YHH3_k127_6315529_0	1033810.HLPCO_000788	2.081e-109	366.0	COG1473@1|root,COG1473@2|Bacteria,2NP7P@2323|unclassified Bacteria	2|Bacteria	S	Peptidase dimerisation domain	hipO3	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
YHH3_k127_6315529_1	1408438.JADD01000010_gene1903	6.821e-50	186.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,27DVV@186827|Aerococcaceae	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
YHH3_k127_6329340_1	439481.Aboo_0134	8.033e-11	74.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
YHH3_k127_6329340_0	69014.TK1267	7.686e-19	97.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
YHH3_k127_6333407_11	2325.TKV_c18760	2.18e-21	97.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
YHH3_k127_6333407_1	224325.AF_1587	4.212e-158	510.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	28890|Euryarchaeota	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39,5.3.2.5	ko:K01601,ko:K08965	ko00270,ko00630,ko00710,ko01100,ko01120,ko01200,map00270,map00630,map00710,map01100,map01120,map01200	M00034,M00165,M00166,M00532	R00024,R03140,R07393	RC00172,RC00859,RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
YHH3_k127_6333407_0	309803.CTN_0956	2.884e-184	590.0	COG2759@1|root,COG2759@2|Bacteria,2GBYR@200918|Thermotogae	200918|Thermotogae	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
YHH3_k127_6333407_5	621372.ACIH01000183_gene3234	1.539e-83	286.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,4H9Q6@91061|Bacilli,26S6Y@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
YHH3_k127_6333407_3	1379698.RBG1_1C00001G1247	2.057e-119	402.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
YHH3_k127_6333407_9	1123276.KB893290_gene5256	2.217e-62	228.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
YHH3_k127_6333407_14	1229783.C273_05817	0.0007822	51.0	COG0454@1|root,COG0456@2|Bacteria,1V3IC@1239|Firmicutes,4HH45@91061|Bacilli,4H04J@90964|Staphylococcaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yvbK	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
YHH3_k127_6333407_10	1538295.JY96_10650	3.833e-28	126.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2VTTR@28216|Betaproteobacteria,1KIVH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Tryptophan halogenase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
YHH3_k127_6333407_2	264732.Moth_0443	1.161e-145	478.0	COG0095@1|root,COG1852@1|root,COG0095@2|Bacteria,COG1852@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,42ET4@68295|Thermoanaerobacterales	186801|Clostridia	H	biotin lipoate A B protein ligase	lipM	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
YHH3_k127_6333407_6	525909.Afer_1054	7.979e-75	263.0	COG1856@1|root,COG1856@2|Bacteria,2H3RG@201174|Actinobacteria	201174|Actinobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
YHH3_k127_6333407_4	380749.HY04AAS1_0592	4.802e-103	348.0	COG2516@1|root,COG2516@2|Bacteria	2|Bacteria	K	radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
YHH3_k127_6333407_8	1158146.KB907130_gene1373	5.668e-66	239.0	COG0095@1|root,COG0095@2|Bacteria,1RDZE@1224|Proteobacteria	1224|Proteobacteria	H	PFAM biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
YHH3_k127_6333407_7	479434.Sthe_2328	6.738e-71	250.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,27Z66@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_6333407_12	1340434.AXVA01000011_gene3111	2.457e-17	92.0	COG4689@1|root,COG4689@2|Bacteria,1UV7Y@1239|Firmicutes,4I6HW@91061|Bacilli,1ZPPK@1386|Bacillus	91061|Bacilli	Q	Acetoacetate decarboxylase (ADC)	-	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
YHH3_k127_6333407_13	1541960.KQ78_00337	1.362e-05	51.0	COG0671@1|root,COG0671@2|Bacteria,3WUSY@544448|Tenericutes	544448|Tenericutes	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
YHH3_k127_6382002_0	926569.ANT_11560	8.727e-25	120.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
YHH3_k127_6388723_0	368408.Tpen_0291	2.842e-134	441.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPTW@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
YHH3_k127_6388723_4	1365176.N186_02390	4.664e-13	78.0	COG1758@1|root,arCOG01268@2157|Archaea,2XR3X@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03014,ko:K03055	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182,M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
YHH3_k127_6388723_3	591019.Shell_1496	3.987e-28	128.0	COG3174@1|root,arCOG04203@2157|Archaea,2XQR0@28889|Crenarchaeota	28889|Crenarchaeota	P	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
YHH3_k127_6388723_1	525904.Tter_1240	7.482e-88	306.0	COG0124@1|root,COG0124@2|Bacteria,2NNZ7@2323|unclassified Bacteria	2|Bacteria	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
YHH3_k127_6388723_2	694429.Pyrfu_0913	1.874e-74	260.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
YHH3_k127_6407763_2	1094980.Mpsy_1920	8.333e-33	146.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota,2N9G3@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
YHH3_k127_6407763_4	1365176.N186_03930	6.934e-06	53.0	arCOG04275@1|root,arCOG04275@2157|Archaea,2XR2U@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6407763_1	1229909.NSED_07785	3.182e-36	148.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
YHH3_k127_6407763_0	374847.Kcr_0092	1.785e-51	190.0	COG1167@1|root,arCOG00492@2157|Archaea	2157|Archaea	EK	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
YHH3_k127_6407763_3	518766.Rmar_0094	8.065e-19	87.0	COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes	976|Bacteroidetes	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
YHH3_k127_6409377_1	1089553.Tph_c19580	1.644e-79	280.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
YHH3_k127_6409377_0	635013.TherJR_1222	1.165e-80	290.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,266U6@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
YHH3_k127_6409377_2	1105110.MC5_05405	3.757e-15	89.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,47EZV@766|Rickettsiales	766|Rickettsiales	C	Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3,1.6.99.3	ko:K00331,ko:K03940	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	Oxidored_q6
YHH3_k127_6436451_2	1463909.KL585962_gene4754	4.684e-16	85.0	2BA9I@1|root,323PQ@2|Bacteria,2H8E5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6436451_4	1449353.JQMQ01000005_gene687	1.414e-08	59.0	COG0095@1|root,COG0095@2|Bacteria,2GJV5@201174|Actinobacteria	201174|Actinobacteria	H	biotin lipoate A B protein ligase	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
YHH3_k127_6436451_1	744872.Spica_1727	8.109e-76	261.0	COG0095@1|root,COG0095@2|Bacteria,2J7CV@203691|Spirochaetes	203691|Spirochaetes	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
YHH3_k127_6436451_0	592015.HMPREF1705_00650	1.001e-83	288.0	COG2516@1|root,COG2516@2|Bacteria,3TB3Y@508458|Synergistetes	508458|Synergistetes	S	Radical SAM domain protein	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
YHH3_k127_6436451_3	891968.Anamo_1108	4.341e-11	72.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	lytH	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	DUF3289,Peptidase_M23
YHH3_k127_646646_1	592027.CLG_B0976	4.353e-27	114.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,36JKZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_646646_0	65093.PCC7418_3042	1.279e-79	274.0	COG2006@1|root,COG2006@2|Bacteria,1G0X0@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
YHH3_k127_646646_2	1227352.C173_05286	1.359e-20	102.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli,26VD8@186822|Paenibacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_6467326_0	304371.MCP_0630	1.461e-177	577.0	arCOG03315@1|root,arCOG03315@2157|Archaea,2Y2NW@28890|Euryarchaeota,2NACC@224756|Methanomicrobia	224756|Methanomicrobia	S	DUF3160	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160
YHH3_k127_6472552_0	1268239.PALB_27090	3.713e-38	151.0	COG2039@1|root,COG2039@2|Bacteria,1MWYG@1224|Proteobacteria,1RPYK@1236|Gammaproteobacteria,2Q0D7@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
YHH3_k127_6472552_1	398512.JQKC01000014_gene1599	3.662e-17	87.0	COG0739@1|root,COG4870@1|root,COG0739@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185,GBS_Bsp-like,OapA,Peptidase_C1,Peptidase_M23
YHH3_k127_6479216_1	926561.KB900617_gene1648	6.204e-11	63.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,3WAUW@53433|Halanaerobiales	186801|Clostridia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
YHH3_k127_6479216_0	387631.Asulf_01194	8.634e-40	155.0	COG0655@1|root,arCOG02573@2157|Archaea,2Y1YT@28890|Euryarchaeota	28890|Euryarchaeota	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_653577_0	646529.Desaci_0769	1.994e-89	304.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,2606M@186807|Peptococcaceae	186801|Clostridia	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
YHH3_k127_653577_1	1229909.NSED_06385	1.91e-38	151.0	COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
YHH3_k127_6551070_1	1236689.MMALV_13770	1.227e-22	104.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,3F2QP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6551070_0	633148.Tagg_0787	2.169e-94	322.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
YHH3_k127_6557124_1	768710.DesyoDRAFT_4272	9.931e-08	59.0	COG0838@1|root,COG0838@2|Bacteria,1V6P3@1239|Firmicutes,24QYA@186801|Clostridia,2670N@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
YHH3_k127_6557124_0	756499.Desde_3235	3.646e-18	86.0	COG0377@1|root,COG0377@2|Bacteria,1TZS1@1239|Firmicutes,24GH5@186801|Clostridia,261VX@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
YHH3_k127_6575425_5	1365176.N186_01240	1.325e-23	103.0	arCOG00299@1|root,arCOG00299@2157|Archaea,2XQKR@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6575425_6	1048983.EL17_19235	2.309e-11	72.0	COG2020@1|root,COG2020@2|Bacteria,4NTXI@976|Bacteroidetes,47RFP@768503|Cytophagia	976|Bacteroidetes	O	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
YHH3_k127_6575425_3	211114.JOEF01000034_gene1433	4.469e-73	261.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4E0Z4@85010|Pseudonocardiales	201174|Actinobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
YHH3_k127_6575425_1	644281.MFS40622_1394	2.414e-92	313.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23QG1@183939|Methanococci	183939|Methanococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	Intein_splicing,TFIIB,TF_Zn_Ribbon
YHH3_k127_6575425_4	406327.Mevan_0799	2.441e-24	112.0	COG4088@1|root,arCOG01041@2157|Archaea,2XWNQ@28890|Euryarchaeota,23QTG@183939|Methanococci	183939|Methanococci	F	PFAM Chromatin associated protein KTI12	pstK	-	2.7.1.164	ko:K10837	ko00450,ko00970,map00450,map00970	-	R08223	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	KTI12
YHH3_k127_6575425_0	573063.Metin_0661	9.477e-101	343.0	KOG4482@1|root,arCOG00119@2157|Archaea,2XV24@28890|Euryarchaeota,23Q57@183939|Methanococci	183939|Methanococci	J	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	spcS	-	2.9.1.2	ko:K03341	ko00450,ko00970,map00450,map00970	-	R08224	RC02965,RC02966	ko00000,ko00001,ko01000	-	-	-	SepSecS
YHH3_k127_6575425_2	573063.Metin_1267	6.851e-92	319.0	COG3276@1|root,arCOG01564@2157|Archaea,2Y862@28890|Euryarchaeota,23QEK@183939|Methanococci	183939|Methanococci	J	elongation factor Tu domain 2 protein	selB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2
YHH3_k127_6580899_0	1210908.HSB1_42480	4.976e-53	213.0	COG2304@1|root,arCOG07561@1|root,arCOG02902@2157|Archaea,arCOG07561@2157|Archaea,2XUQK@28890|Euryarchaeota,23TQB@183963|Halobacteria	183963|Halobacteria	K	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6580899_1	1392498.JQLH01000001_gene1013	1.032e-40	159.0	COG0498@1|root,COG0498@2|Bacteria,4NKWI@976|Bacteroidetes,1HZYM@117743|Flavobacteriia,2PHY4@252356|Maribacter	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
YHH3_k127_6580899_2	446462.Amir_3773	0.0006972	44.0	COG0477@1|root,COG0477@2|Bacteria,2I2J7@201174|Actinobacteria,4EE57@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
YHH3_k127_659542_1	1459636.NTE_02874	1.004e-18	99.0	COG2404@1|root,arCOG00423@2157|Archaea	2157|Archaea	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_659542_0	439235.Dalk_2981	2.168e-27	114.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42Q2C@68525|delta/epsilon subdivisions,2WKNN@28221|Deltaproteobacteria,2MN1W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
YHH3_k127_6644992_0	666509.RCA23_c04090	1.523e-11	70.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
YHH3_k127_6644992_1	1449347.JQLN01000005_gene3988	9.462e-08	59.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,2M45S@2063|Kitasatospora	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_6660500_0	1122925.KB895381_gene3810	1.169e-83	288.0	COG0702@1|root,COG0702@2|Bacteria,1UNWK@1239|Firmicutes,4IUSY@91061|Bacilli,277RE@186822|Paenibacillaceae	91061|Bacilli	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6679650_0	1122927.KB895416_gene3544	9.431e-36	151.0	COG2271@1|root,COG2271@2|Bacteria,1UNX4@1239|Firmicutes,4IUTN@91061|Bacilli,26YVJ@186822|Paenibacillaceae	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_6679650_1	28583.AMAG_12053T0	9.416e-16	89.0	KOG0379@1|root,KOG1056@1|root,KOG0379@2759|Eukaryota,KOG1056@2759|Eukaryota	2759|Eukaryota	M	G-protein coupled receptor activity	-	-	4.6.1.2	ko:K04608,ko:K12323	ko00230,ko04022,ko04024,ko04072,ko04080,ko04270,ko04714,ko04724,ko04921,ko04923,ko04924,ko04925,map00230,map04022,map04024,map04072,map04080,map04270,map04714,map04724,map04921,map04923,map04924,map04925	M00694	R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko01009,ko04030	-	-	-	7tm_3,ANF_receptor,Bmp,Kelch_4,Kelch_5,Kelch_6,Pkinase,RVT_1
YHH3_k127_6704467_2	1459636.NTE_01198	3.724e-42	181.0	COG1404@1|root,arCOG03439@1|root,arCOG00704@2157|Archaea,arCOG03439@2157|Archaea,41SEM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_6704467_0	374847.Kcr_1548	4.895e-115	379.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
YHH3_k127_6704467_5	323259.Mhun_2179	0.0005206	47.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH3_k127_6704467_4	456442.Mboo_1535	4.131e-05	49.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
YHH3_k127_6704467_3	456320.Mvol_1557	7.301e-35	146.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,23QHM@183939|Methanococci	183939|Methanococci	H	PFAM Triphosphoribosyl-dephospho-CoA protein	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
YHH3_k127_6704467_1	397948.Cmaq_0442	5.692e-46	171.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
YHH3_k127_6708508_1	868131.MSWAN_0895	1.091e-97	332.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,23NRQ@183925|Methanobacteria	183925|Methanobacteria	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
YHH3_k127_6708508_4	498761.HM1_0379	1.716e-13	77.0	COG0511@1|root,COG0511@2|Bacteria,1VW7S@1239|Firmicutes,25F1E@186801|Clostridia	186801|Clostridia	I	PFAM biotin lipoyl attachment domain-containing protein	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
YHH3_k127_6708508_0	1121472.AQWN01000011_gene1255	1.453e-173	559.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,26167@186807|Peptococcaceae	186801|Clostridia	C	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
YHH3_k127_6708508_3	56780.SYN_00402	1.596e-23	102.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2MQYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
YHH3_k127_67103_4	269797.Mbar_A2330	1.859e-27	117.0	COG0500@1|root,arCOG01773@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH3_k127_67103_1	1121405.dsmv_2622	3.022e-109	369.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42PZ6@68525|delta/epsilon subdivisions,2WKNQ@28221|Deltaproteobacteria,2MI1H@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
YHH3_k127_67103_2	868131.MSWAN_0731	2.813e-95	323.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,23NSF@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
YHH3_k127_67103_3	1041930.Mtc_0353	4.703e-43	166.0	COG2122@1|root,arCOG04376@2157|Archaea,2XV48@28890|Euryarchaeota,2N9HW@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0280 family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_67103_6	696369.KI912183_gene2278	0.0006266	52.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,261PP@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM glycyl-radical enzyme activating protein family	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
YHH3_k127_67103_0	565033.GACE_0621	7.883e-149	483.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2463B@183980|Archaeoglobi	183980|Archaeoglobi	S	Pfam:DUF39	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
YHH3_k127_67103_5	1444711.CCJF01000005_gene918	7.395e-13	78.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
YHH3_k127_674608_1	1423321.AS29_05110	4.005e-08	59.0	COG0239@1|root,COG0239@2|Bacteria,1VM30@1239|Firmicutes,4HRC4@91061|Bacilli	91061|Bacilli	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
YHH3_k127_674608_2	111781.Lepto7376_0432	4.11e-05	52.0	COG0239@1|root,COG0239@2|Bacteria,1G72W@1117|Cyanobacteria,1HBV3@1150|Oscillatoriales	1117|Cyanobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
YHH3_k127_674608_0	797209.ZOD2009_01325	1.018e-13	74.0	COG1733@1|root,arCOG01057@2157|Archaea,2Y0R2@28890|Euryarchaeota,23XJ2@183963|Halobacteria	183963|Halobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
YHH3_k127_6751857_7	1459636.NTE_02554	8.012e-06	50.0	COG1143@1|root,arCOG01543@2157|Archaea,41SGW@651137|Thaumarchaeota	651137|Thaumarchaeota	C	4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4
YHH3_k127_6751857_1	1131266.ARWQ01000015_gene758	1.078e-81	291.0	COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota	651137|Thaumarchaeota	C	plastoquinone (complex I)	-	-	1.6.5.3	ko:K00342,ko:K12137,ko:K12141	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
YHH3_k127_6751857_0	555779.Dthio_PD1228	2.9e-105	369.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MG3C@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
YHH3_k127_6751857_2	1353529.M899_0028	1.154e-81	291.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2MSNQ@213481|Bdellovibrionales,2WJDC@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
YHH3_k127_6751857_3	1267535.KB906767_gene4290	3.235e-71	259.0	COG1007@1|root,COG1007@2|Bacteria,3Y3PV@57723|Acidobacteria,2JIT3@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
YHH3_k127_6751857_6	4641.GSMUA_Achr9P05610_001	1.985e-27	119.0	COG1100@1|root,KOG0087@2759|Eukaryota,37IXT@33090|Viridiplantae,3G8GI@35493|Streptophyta,3KVQB@4447|Liliopsida	35493|Streptophyta	U	Ras-related protein	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005773,GO:0005774,GO:0005886,GO:0006810,GO:0006886,GO:0006950,GO:0006970,GO:0006972,GO:0008104,GO:0008150,GO:0009628,GO:0009651,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0017076,GO:0019001,GO:0031090,GO:0031410,GO:0031982,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042538,GO:0042886,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060627,GO:0065007,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:1901265,GO:1901363	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_6751857_4	1379698.RBG1_1C00001G1133	8.575e-64	232.0	COG1575@1|root,COG1575@2|Bacteria,2NPNN@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
YHH3_k127_6751857_5	304371.MCP_1387	9.982e-42	169.0	COG2202@1|root,arCOG06712@1|root,arCOG06515@2157|Archaea,arCOG06712@2157|Archaea,2Y7SX@28890|Euryarchaeota,2NBM4@224756|Methanomicrobia	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_4,PAS_8,PAS_9
YHH3_k127_6792283_4	391623.TERMP_01217	8.745e-34	138.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
YHH3_k127_6792283_0	479434.Sthe_0784	1.32e-114	381.0	COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia	189775|Thermomicrobia	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
YHH3_k127_6792283_1	1499689.CCNN01000007_gene2444	7.887e-99	336.0	COG1239@1|root,COG1239@2|Bacteria,1UHYK@1239|Firmicutes,24BJ0@186801|Clostridia,36HIP@31979|Clostridiaceae	186801|Clostridia	H	Magnesium chelatase, subunit ChlI	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
YHH3_k127_6792283_5	1464048.JNZS01000001_gene142	3.23e-17	95.0	COG1239@1|root,COG1240@1|root,COG1239@2|Bacteria,COG1240@2|Bacteria,2GN3S@201174|Actinobacteria,4DB1M@85008|Micromonosporales	201174|Actinobacteria	H	Magnesium chelatase, subunit ChlI	chlI	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
YHH3_k127_6792283_2	604354.TSIB_0767	4.945e-94	320.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
YHH3_k127_6792283_3	1042877.GQS_02110	3.474e-41	162.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,2430B@183968|Thermococci	183968|Thermococci	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
YHH3_k127_6800332_0	444158.MmarC6_0522	5.741e-37	154.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,23QRM@183939|Methanococci	183939|Methanococci	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,HI0933_like
YHH3_k127_6800332_1	756499.Desde_3025	3.261e-26	115.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,262Q4@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
YHH3_k127_6806015_1	1041930.Mtc_0368	1.778e-11	72.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota,2N9G3@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
YHH3_k127_6806015_0	1430331.EP10_06355	1.627e-11	74.0	COG4886@1|root,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,4HM8K@91061|Bacilli	91061|Bacilli	E	Leucine-rich repeat (LRR) protein	inlA	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030260,GO:0030312,GO:0035635,GO:0044403,GO:0044409,GO:0044419,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944	-	ko:K13730,ko:K13731	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Flg_new,Gram_pos_anchor,Internalin_N,LRR_4,LRR_6,LRR_adjacent,NEAT,SLH,Strep_his_triad,fn3
YHH3_k127_6806015_2	1068978.AMETH_3549	5.532e-11	68.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4DX8Q@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
YHH3_k127_6806544_0	1268072.PSAB_08760	1.24e-07	59.0	COG1522@1|root,COG1522@2|Bacteria,1V7Q6@1239|Firmicutes,4HJKF@91061|Bacilli,26WZX@186822|Paenibacillaceae	91061|Bacilli	K	AsnC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_6822123_2	446462.Amir_2848	3.138e-20	96.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
YHH3_k127_6822123_4	290315.Clim_1580	8.953e-05	53.0	COG0633@1|root,COG0633@2|Bacteria,1FF1K@1090|Chlorobi	1090|Chlorobi	C	PFAM ferredoxin	-	GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858	-	ko:K08952	-	-	-	-	ko00000,ko00194	-	-	-	DUF4332,Fer2
YHH3_k127_6822123_0	1499967.BAYZ01000137_gene110	8.45e-60	219.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
YHH3_k127_6822123_3	673860.AciM339_0522	8.213e-10	71.0	arCOG02499@1|root,arCOG02550@1|root,arCOG02499@2157|Archaea,arCOG02550@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD,Pkinase
YHH3_k127_6822123_1	309798.COPRO5265_0451	2.98e-20	104.0	COG0308@1|root,COG0308@2|Bacteria,1VMQ2@1239|Firmicutes	1239|Firmicutes	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
YHH3_k127_6877327_1	877455.Metbo_0494	8.167e-50	192.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota	28890|Euryarchaeota	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
YHH3_k127_6877327_0	1121422.AUMW01000045_gene1210	1.687e-162	532.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260YA@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
YHH3_k127_6900792_1	865861.AZSU01000003_gene2122	5.247e-51	184.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,36DK8@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
YHH3_k127_6900792_0	574087.Acear_1941	1.097e-267	832.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,3WB0U@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
YHH3_k127_6912401_0	555079.Toce_1777	4.617e-45	184.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,42FS7@68295|Thermoanaerobacterales	186801|Clostridia	M	Serine protease with a broad substrate specificity	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
YHH3_k127_6916597_4	696747.NIES39_C02640	2.838e-09	69.0	COG0457@1|root,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1H968@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8,Trypsin_2
YHH3_k127_6916597_3	877455.Metbo_1459	3.407e-11	70.0	COG0457@1|root,arCOG03048@1|root,arCOG03038@2157|Archaea,arCOG03048@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
YHH3_k127_6916597_1	1385935.N836_09175	2.747e-16	84.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_1,TPR_11,TPR_14,TPR_16,TPR_2,TPR_6,TPR_8
YHH3_k127_6916597_2	5888.CAK83391	4.717e-15	78.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
YHH3_k127_6916597_5	36080.S2K774	2.778e-06	56.0	COG0468@1|root,KOG1434@2759|Eukaryota,39J83@33154|Opisthokonta,3NVB0@4751|Fungi,1GSAC@112252|Fungi incertae sedis	4751|Fungi	L	Helix-hairpin-helix DNA-binding motif class 1	-	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000709,GO:0000724,GO:0000725,GO:0000730,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006311,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007130,GO:0007131,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010520,GO:0010564,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022414,GO:0022607,GO:0030554,GO:0031323,GO:0031974,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0033043,GO:0033554,GO:0034622,GO:0034641,GO:0035639,GO:0035822,GO:0035825,GO:0036094,GO:0040020,GO:0042148,GO:0042623,GO:0042802,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044877,GO:0045003,GO:0045132,GO:0045143,GO:0046483,GO:0048285,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051128,GO:0051171,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051445,GO:0051716,GO:0051726,GO:0051783,GO:0060255,GO:0060631,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070192,GO:0070193,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090735,GO:0097159,GO:0097367,GO:0098813,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1903046,GO:1905334,GO:2000241	-	ko:K10872,ko:K14545	ko03008,ko04113,map03008,map04113	-	-	-	ko00000,ko00001,ko03009,ko03400	-	-	-	HHH_5,Rad51
YHH3_k127_6916597_0	926561.KB900617_gene1593	6.001e-41	171.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,3WB1Q@53433|Halanaerobiales	186801|Clostridia	F	5'-nucleotidase, C-terminal domain	ushA	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,LysM,Metallophos,SLH
YHH3_k127_6957835_6	1449050.JNLE01000003_gene3185	9.982e-30	124.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,36ED9@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
YHH3_k127_6957835_2	935948.KE386494_gene459	9.127e-106	357.0	COG0167@1|root,COG0167@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,42FY6@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM dihydroorotate dehydrogenase family protein	preA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_20,Fer4_21,Fer4_6
YHH3_k127_6957835_0	555779.Dthio_PD0371	1.012e-166	537.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,2M8B8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
YHH3_k127_6957835_3	945713.IALB_1230	1.921e-58	213.0	COG0121@1|root,COG0121@2|Bacteria	2|Bacteria	S	cellular modified histidine biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,GATase_4,Transglut_core
YHH3_k127_6957835_1	485913.Krac_3682	4.198e-162	520.0	COG0673@1|root,COG0673@2|Bacteria,2G7RI@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
YHH3_k127_6957835_9	913865.DOT_1495	6.502e-12	72.0	COG2318@1|root,COG2318@2|Bacteria,1V51W@1239|Firmicutes	1239|Firmicutes	S	DinB family	dinB	-	-	-	-	-	-	-	-	-	-	-	DinB
YHH3_k127_6957835_10	497964.CfE428DRAFT_5669	9.691e-11	72.0	COG4285@1|root,COG4285@2|Bacteria,46V2C@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Biotin-protein ligase, N terminal	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
YHH3_k127_6957835_8	1227360.C176_21271	1.958e-12	72.0	COG0346@1|root,COG0346@2|Bacteria,1V8PA@1239|Firmicutes,4HK6F@91061|Bacilli,26FN6@186818|Planococcaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
YHH3_k127_6957835_4	596151.DesfrDRAFT_3332	7.315e-47	175.0	COG1853@1|root,COG1853@2|Bacteria,1RBSR@1224|Proteobacteria,42R0G@68525|delta/epsilon subdivisions,2WMYE@28221|Deltaproteobacteria,2MAM7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
YHH3_k127_6957835_5	102125.Xen7305DRAFT_00036690	2.707e-30	123.0	COG1669@1|root,COG1669@2|Bacteria,1G804@1117|Cyanobacteria,3VN2B@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
YHH3_k127_6957835_7	65393.PCC7424_0997	2.701e-27	114.0	COG2361@1|root,COG2361@2|Bacteria,1G7XA@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG2361 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
YHH3_k127_6967727_8	351160.RCIX2666	1.484e-22	106.0	COG0491@1|root,arCOG00504@2157|Archaea	2157|Archaea	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_6967727_3	1131730.BAVI_19419	1.101e-38	160.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4HATE@91061|Bacilli,1ZDCS@1386|Bacillus	91061|Bacilli	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	macB1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
YHH3_k127_6967727_1	1449126.JQKL01000018_gene3254	2.253e-70	245.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,268T7@186813|unclassified Clostridiales	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_6967727_5	868131.MSWAN_2427	7.583e-32	126.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
YHH3_k127_6967727_9	593750.Metfor_1048	9.811e-14	77.0	arCOG08981@1|root,arCOG08981@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6967727_13	243164.DET0017	7.043e-08	56.0	2BQDM@1|root,32J8W@2|Bacteria,2GB0B@200795|Chloroflexi,34DPG@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6967727_6	1122609.AUGT01000021_gene1190	2.822e-31	134.0	2DM3D@1|root,31J5I@2|Bacteria,2I578@201174|Actinobacteria,4DWXX@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF2785)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2785
YHH3_k127_6967727_11	243164.DET0017	8.166e-10	61.0	2BQDM@1|root,32J8W@2|Bacteria,2GB0B@200795|Chloroflexi,34DPG@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6967727_4	1218103.CIN01S_10_01710	1.964e-33	132.0	COG0346@1|root,COG0346@2|Bacteria,4NNNG@976|Bacteroidetes,1I1XF@117743|Flavobacteriia,3ZS7I@59732|Chryseobacterium	976|Bacteroidetes	E	glyoxalase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
YHH3_k127_6967727_0	309799.DICTH_1698	1.168e-110	367.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
YHH3_k127_6967727_2	269797.Mbar_A0524	7.028e-47	182.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y29P@28890|Euryarchaeota,2NA5X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_6967727_7	593907.Celgi_2707	1.087e-22	111.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4F24I@85016|Cellulomonadaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
YHH3_k127_6967727_12	593750.Metfor_1391	1.507e-09	63.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
YHH3_k127_6967727_10	314345.SPV1_10641	3.654e-12	74.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria	1224|Proteobacteria	O	isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
YHH3_k127_7002612_31	1163745.HCD_03975	2.662e-05	48.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2YM98@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
YHH3_k127_7002612_12	397948.Cmaq_1073	6.104e-61	217.0	COG2220@1|root,arCOG00497@2157|Archaea,2XPSC@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
YHH3_k127_7002612_4	186497.PF1725	9.668e-104	352.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
YHH3_k127_7002612_3	439481.Aboo_1394	5.066e-104	356.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,3F2HJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	AAA domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
YHH3_k127_7002612_10	593117.TGAM_1098	3.523e-73	259.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
YHH3_k127_7002612_7	1236689.MMALV_16390	3.611e-81	283.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
YHH3_k127_7002612_13	633148.Tagg_1300	8.38e-56	203.0	COG2413@1|root,arCOG04066@2157|Archaea,2XQ4I@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
YHH3_k127_7002612_9	604354.TSIB_1168	1.208e-75	264.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
YHH3_k127_7002612_16	342949.PNA2_0772	1.199e-48	188.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
YHH3_k127_7002612_17	573064.Mefer_0036	1.041e-32	130.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23R2F@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
YHH3_k127_7002612_0	267377.MMP1208	7.853e-149	481.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
YHH3_k127_7002612_21	529709.PYCH_02040	5.822e-20	94.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
YHH3_k127_7002612_14	195522.BD01_1505	1.02e-53	196.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,243RT@183968|Thermococci	183968|Thermococci	K	DNA-directed RNA polymerase, subunit E	rpoE1	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
YHH3_k127_7002612_28	604354.TSIB_0027	6.226e-10	62.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,244KC@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
YHH3_k127_7002612_26	269797.Mbar_A0282	1.678e-12	72.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,2NA0E@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
YHH3_k127_7002612_25	410358.Mlab_0654	2.003e-13	73.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
YHH3_k127_7002612_1	264732.Moth_1287	2.534e-126	415.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,42FP2@68295|Thermoanaerobacterales	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
YHH3_k127_7002612_22	279714.FuraDRAFT_0513	9.907e-16	87.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VN1Z@28216|Betaproteobacteria	28216|Betaproteobacteria	S	beta-lactamase	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Lactamase_B
YHH3_k127_7002612_24	186497.PF0620	1.092e-14	77.0	COG1342@1|root,arCOG02238@2157|Archaea,2XYBJ@28890|Euryarchaeota,244BD@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0251 family	-	-	-	ko:K06933	-	-	-	-	ko00000	-	-	-	DUF134
YHH3_k127_7002612_8	1121405.dsmv_1348	3.092e-80	276.0	COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions,2WJ9M@28221|Deltaproteobacteria,2MIKP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
YHH3_k127_7002612_5	1094980.Mpsy_0774	4.041e-93	313.0	COG1149@1|root,arCOG04073@2157|Archaea,2XWI1@28890|Euryarchaeota,2N9GG@224756|Methanomicrobia	224756|Methanomicrobia	D	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
YHH3_k127_7002612_23	416591.Tlet_0387	1.907e-15	80.0	COG1433@1|root,COG1433@2|Bacteria	2|Bacteria	S	nitrogen fixation	VPA0323	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
YHH3_k127_7002612_18	269797.Mbar_A1834	9.402e-31	126.0	COG1433@1|root,arCOG02734@2157|Archaea,2XZWT@28890|Euryarchaeota,2N9ZY@224756|Methanomicrobia	224756|Methanomicrobia	S	Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
YHH3_k127_7002612_2	420247.Msm_1164	7.813e-121	401.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,23NMZ@183925|Methanobacteria	183925|Methanobacteria	J	PFAM GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
YHH3_k127_7002612_15	760568.Desku_1009	2.606e-50	185.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,2620R@186807|Peptococcaceae	186801|Clostridia	S	DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
YHH3_k127_7002612_6	1041930.Mtc_0048	1.474e-86	296.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
YHH3_k127_7002612_11	1042877.GQS_04495	8.305e-67	233.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
YHH3_k127_7002612_30	1070774.J07HN4v3_01193	2.118e-07	59.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,23VKT@183963|Halobacteria	183963|Halobacteria	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
YHH3_k127_7002612_29	186497.PF1378	4.66e-09	61.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2445Q@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
YHH3_k127_7002612_27	444157.Tneu_1283	1.807e-12	73.0	COG1310@1|root,arCOG01138@2157|Archaea,2XRGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
YHH3_k127_7002612_20	1134413.ANNK01000031_gene1437	3.46e-25	110.0	COG1522@1|root,COG1522@2|Bacteria,1V72S@1239|Firmicutes,4HJS3@91061|Bacilli,1ZGCT@1386|Bacillus	91061|Bacilli	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_7002612_19	525904.Tter_0543	2.596e-27	114.0	COG3294@1|root,COG3294@2|Bacteria,2NR9E@2323|unclassified Bacteria	2|Bacteria	S	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
YHH3_k127_700705_1	479434.Sthe_0137	1.772e-25	114.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi,27Y3N@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_700705_0	1343739.PAP_01565	7.807e-28	118.0	COG1351@1|root,arCOG01883@2157|Archaea,2XY5D@28890|Euryarchaeota,2437H@183968|Thermococci	183968|Thermococci	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
YHH3_k127_7011108_1	5911.EAR97888	6.323e-30	126.0	KOG0078@1|root,KOG0078@2759|Eukaryota,3ZDBC@5878|Ciliophora	5878|Ciliophora	U	Ras family	-	-	-	-	-	-	-	-	-	-	-	-	Ras
YHH3_k127_7011108_0	697281.Mahau_1243	3.605e-176	575.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
YHH3_k127_7019433_1	192952.MM_1237	1.21e-52	192.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
YHH3_k127_7019433_2	589924.Ferp_1176	5.736e-40	158.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_7019433_0	593117.TGAM_2149	5.568e-89	297.0	COG0110@1|root,arCOG01848@2157|Archaea,2XWJM@28890|Euryarchaeota,242NY@183968|Thermococci	183968|Thermococci	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
YHH3_k127_7019433_3	55529.EKX45323	1.665e-09	59.0	COG0480@1|root,KOG0467@2759|Eukaryota	2759|Eukaryota	J	GTPase activity	-	-	-	ko:K03234,ko:K14536	ko03008,ko04152,ko04921,map03008,map04152,map04921	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
YHH3_k127_7028461_0	1132509.C447_16274	1.781e-102	344.0	COG0604@1|root,arCOG01458@2157|Archaea,2XU0Q@28890|Euryarchaeota,23SPC@183963|Halobacteria	183963|Halobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor1	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_7028461_4	272557.APE_1495a	2.119e-13	72.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
YHH3_k127_7028461_1	391623.TERMP_01834	6.903e-71	246.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
YHH3_k127_7028461_2	573064.Mefer_0477	4.224e-55	204.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23QKP@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
YHH3_k127_7028461_3	523845.AQXV01000040_gene1686	2.664e-14	83.0	COG0327@1|root,arCOG04454@2157|Archaea,2XT5G@28890|Euryarchaeota,23QHY@183939|Methanococci	183939|Methanococci	S	NIF3 (NGG1p interacting factor 3)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
YHH3_k127_7031562_1	1122939.ATUD01000001_gene426	0.0008282	42.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4CR8G@84995|Rubrobacteria	84995|Rubrobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
YHH3_k127_7031562_0	386456.JQKN01000017_gene835	7.597e-100	341.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota	28890|Euryarchaeota	P	COG0607 Rhodanese-related sulfurtransferase	-	-	2.8.1.1,2.8.1.2,3.1.2.6	ko:K01011,ko:K01069	ko00270,ko00620,ko00920,ko01100,ko01120,ko04122,map00270,map00620,map00920,map01100,map01120,map04122	-	R01736,R01931,R03105,R03106	RC00004,RC00137,RC00214	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
YHH3_k127_7067315_0	1365176.N186_00370	6.159e-49	187.0	COG0451@1|root,arCOG01369@2157|Archaea,2XRSX@28889|Crenarchaeota	28889|Crenarchaeota	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
YHH3_k127_7072525_5	944479.JQLX01000012_gene1109	6.027e-16	85.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2M73M@213113|Desulfurellales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH3_k127_7072525_3	1041930.Mtc_1495	3.908e-63	223.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,2N9M4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
YHH3_k127_7072525_6	665571.STHERM_c16470	1.418e-13	77.0	COG0346@1|root,COG0346@2|Bacteria,2J7HC@203691|Spirochaetes	203691|Spirochaetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
YHH3_k127_7072525_1	1322246.BN4_20350	2.425e-97	327.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MATV@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Dehydrogenase, E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
YHH3_k127_7072525_0	891968.Anamo_1263	9.952e-121	395.0	COG0022@1|root,COG0022@2|Bacteria,3TA38@508458|Synergistetes	508458|Synergistetes	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
YHH3_k127_7072525_4	604354.TSIB_1816	7.423e-61	219.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,245B1@183968|Thermococci	183968|Thermococci	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
YHH3_k127_7072525_2	399550.Smar_1111	4.163e-96	327.0	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
YHH3_k127_709601_0	523845.AQXV01000055_gene95	1.736e-135	445.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
YHH3_k127_7140903_1	981369.JQMJ01000003_gene7226	4.411e-07	55.0	COG0455@1|root,COG0455@2|Bacteria,2I8H2@201174|Actinobacteria,2NM50@228398|Streptacidiphilus	201174|Actinobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA
YHH3_k127_7140903_0	316067.Geob_3357	3.487e-08	66.0	COG3420@1|root,COG3420@2|Bacteria,1QWWH@1224|Proteobacteria	1224|Proteobacteria	P	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,W_rich_C
YHH3_k127_7151658_4	1459636.NTE_02779	8.556e-38	146.0	COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	tRNA methyl transferase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	QueC
YHH3_k127_7151658_1	1379698.RBG1_1C00001G1193	4.782e-116	385.0	COG0006@1|root,COG0006@2|Bacteria,2NQIC@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
YHH3_k127_7151658_2	1303518.CCALI_00439	5.97e-109	364.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	MA20_31690	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
YHH3_k127_7151658_5	1047013.AQSP01000144_gene918	7.935e-23	99.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
YHH3_k127_7151658_0	1047013.AQSP01000144_gene916	4.645e-171	544.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
YHH3_k127_7151658_3	1047013.AQSP01000144_gene915	1.958e-53	192.0	COG0492@1|root,COG0822@1|root,COG0492@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_oxidored,FeS_assembly_P,NifU_N,Pyr_redox_2,cNMP_binding
YHH3_k127_7157911_0	1033810.HLPCO_002135	0.0006042	51.0	COG3291@1|root,COG3391@1|root,COG4886@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,2NR3W@2323|unclassified Bacteria	2|Bacteria	M	NLP P60 protein	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	CHU_C,DUF4988,PKD
YHH3_k127_7158097_0	192952.MM_3157	1.267e-69	251.0	COG1680@1|root,arCOG00771@2157|Archaea	2157|Archaea	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1202	Beta-lactamase
YHH3_k127_7158097_1	1070774.J07HN4v3_01629	9.533e-11	64.0	COG0642@1|root,arCOG06796@1|root,arCOG02358@2157|Archaea,arCOG06796@2157|Archaea,2Y7KE@28890|Euryarchaeota	28890|Euryarchaeota	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9
YHH3_k127_72248_1	263820.PTO0404	1.546e-23	110.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,241Q6@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
YHH3_k127_72248_0	1196324.A374_16783	1.758e-46	177.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli	91061|Bacilli	L	Hydrolase, tatd	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
YHH3_k127_7229949_0	1033810.HLPCO_001930	1.128e-06	61.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	DUF1863,F-box-like,OmpA,TIR_2,VWA,WD40
YHH3_k127_7261776_1	660470.Theba_1590	9.243e-24	104.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,DUF4185
YHH3_k127_7261776_0	304371.MCP_0425	2.14e-64	223.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXTN@28890|Euryarchaeota,2NB5F@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
YHH3_k127_7277325_0	1173020.Cha6605_0959	4.916e-59	214.0	COG0508@1|root,COG0508@2|Bacteria,1G4MH@1117|Cyanobacteria	1117|Cyanobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
YHH3_k127_7284587_3	1116375.VEJY3_16476	9.024e-16	81.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,1RXJU@1236|Gammaproteobacteria,1XXB3@135623|Vibrionales	135623|Vibrionales	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	DctP,Peripla_BP_6
YHH3_k127_7284587_1	1131730.BAVI_09806	1.384e-46	178.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,4HBFZ@91061|Bacilli,1ZBPA@1386|Bacillus	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
YHH3_k127_7284587_2	1123386.AUIW01000001_gene217	1.472e-44	177.0	COG4177@1|root,COG4177@2|Bacteria,1WIGX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
YHH3_k127_7284587_0	574087.Acear_1487	1.985e-123	413.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_7298966_1	368408.Tpen_0856	4.924e-72	251.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
YHH3_k127_7298966_0	289376.THEYE_A0984	7.47e-142	469.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
YHH3_k127_7303176_1	1183377.Py04_0419	8.985e-07	60.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2432R@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
YHH3_k127_7303176_0	1123508.JH636443_gene5018	9.717e-15	77.0	COG3324@1|root,COG3324@2|Bacteria,2J3W8@203682|Planctomycetes	203682|Planctomycetes	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_7304378_2	1217714.F975_01479	1.169e-08	62.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,1SF1R@1236|Gammaproteobacteria,3NP0V@468|Moraxellaceae	1236|Gammaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
YHH3_k127_7304378_3	1123073.KB899241_gene2268	6.031e-07	62.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7304378_0	1041930.Mtc_1964	8.402e-50	190.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
YHH3_k127_7304378_1	316274.Haur_2917	3e-24	115.0	COG4805@1|root,COG4805@2|Bacteria,2G8D3@200795|Chloroflexi	200795|Chloroflexi	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7306295_0	351160.RRC476	5.573e-20	94.0	COG0784@1|root,arCOG02391@2157|Archaea,2Y6EC@28890|Euryarchaeota,2NBEQ@224756|Methanomicrobia	224756|Methanomicrobia	T	Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
YHH3_k127_7320023_2	604354.TSIB_0221	4.006e-103	351.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,242Z4@183968|Thermococci	183968|Thermococci	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
YHH3_k127_7320023_1	591019.Shell_0665	1.113e-104	352.0	COG3839@1|root,arCOG00177@2157|Archaea,2XSPU@28889|Crenarchaeota	28889|Crenarchaeota	E	COGs COG3842 ABC-type spermidine putrescine transport systems ATPase components	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
YHH3_k127_7320023_0	644281.MFS40622_1703	2.026e-133	450.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,23QBR@183939|Methanococci	183939|Methanococci	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
YHH3_k127_7320023_4	1041930.Mtc_0091	4.095e-69	250.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2N99S@224756|Methanomicrobia	224756|Methanomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
YHH3_k127_7320023_3	795359.TOPB45_0396	1.455e-83	287.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	metF3	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
YHH3_k127_7320023_5	1123288.SOV_3c09880	1.167e-19	92.0	COG1962@1|root,COG1962@2|Bacteria,1UYYD@1239|Firmicutes	1239|Firmicutes	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
YHH3_k127_732853_1	396595.TK90_0529	1.106e-05	58.0	COG5001@1|root,COG5001@2|Bacteria,1RC0H@1224|Proteobacteria	1224|Proteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GGDEF,PAS_3,PAS_4,PAS_9
YHH3_k127_732853_0	243164.DET0127	5.897e-29	134.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,2G8WY@200795|Chloroflexi,34D2J@301297|Dehalococcoidia	301297|Dehalococcoidia	T	GAF domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9
YHH3_k127_735693_2	1280688.AUJB01000016_gene1557	8.372e-09	63.0	COG5015@1|root,COG5015@2|Bacteria,1V43Y@1239|Firmicutes,24HQB@186801|Clostridia,3NI6P@46205|Pseudobutyrivibrio	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
YHH3_k127_735693_0	1343739.PAP_00125	1.205e-27	118.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,24470@183968|Thermococci	183968|Thermococci	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
YHH3_k127_735693_1	1121904.ARBP01000018_gene2664	2.825e-23	104.0	COG3631@1|root,COG3631@2|Bacteria,4P6WY@976|Bacteroidetes,47WIZ@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
YHH3_k127_7369187_1	1089548.KI783301_gene153	1.929e-68	244.0	COG0152@1|root,COG1828@1|root,COG0152@2|Bacteria,COG1828@2|Bacteria,1TP11@1239|Firmicutes,4H9U8@91061|Bacilli,3WEMZ@539002|Bacillales incertae sedis	91061|Bacilli	F	phosphoribosylaminoimidazole-succinocarboxamide synthase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
YHH3_k127_7369187_0	572546.Arcpr_1231	1.541e-135	439.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,246UQ@183980|Archaeoglobi	183980|Archaeoglobi	F	IMP biosynthesis enzyme PurP domain protein	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
YHH3_k127_7369187_2	453591.Igni_0442	1.345e-67	237.0	COG1759@1|root,arCOG04346@2157|Archaea,2XPSG@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
YHH3_k127_738425_7	698757.Pogu_0803	2.508e-15	77.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
YHH3_k127_738425_5	268739.Nmlp_1554	1.785e-22	109.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,23W2W@183963|Halobacteria	183963|Halobacteria	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
YHH3_k127_738425_8	1324957.K933_03955	4.016e-05	55.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23V74@183963|Halobacteria	183963|Halobacteria	H	Phosphopantetheine adenylyltransferase	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
YHH3_k127_738425_4	415426.Hbut_1243	7.227e-38	151.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
YHH3_k127_738425_6	591019.Shell_0049	2.043e-22	105.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
YHH3_k127_738425_2	444158.MmarC6_1459	1.911e-44	165.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
YHH3_k127_738425_1	192952.MM_0870	1.19e-131	430.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
YHH3_k127_738425_0	877455.Metbo_1378	2.256e-142	460.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
YHH3_k127_738425_3	523845.AQXV01000043_gene287	7.471e-40	159.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,23QMU@183939|Methanococci	183939|Methanococci	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_6
YHH3_k127_7410786_0	768706.Desor_1472	8.339e-39	149.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_7410786_2	589924.Ferp_1318	3.612e-17	91.0	COG1600@1|root,arCOG02740@2157|Archaea,2XVBB@28890|Euryarchaeota,245SR@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S double cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_16
YHH3_k127_7410786_1	573063.Metin_0381	5.388e-25	108.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
YHH3_k127_7415802_0	351160.LRC381	2.474e-127	415.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,2N9H8@224756|Methanomicrobia	224756|Methanomicrobia	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
YHH3_k127_7418519_1	1123288.SOV_5c01120	2.783e-09	60.0	COG2020@1|root,COG2020@2|Bacteria,1V495@1239|Firmicutes	1239|Firmicutes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
YHH3_k127_7418519_0	641491.DND132_3227	1.297e-94	327.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2M8S9@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
YHH3_k127_7434531_1	293826.Amet_4279	1.113e-06	59.0	COG1266@1|root,COG1266@2|Bacteria,1V1I8@1239|Firmicutes,24EXX@186801|Clostridia,36IEW@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
YHH3_k127_7434531_0	439481.Aboo_0620	9.055e-11	70.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
YHH3_k127_7446375_0	485913.Krac_11127	0.0001754	45.0	COG1708@1|root,COG1708@2|Bacteria,2G9SK@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
YHH3_k127_74704_1	936455.KI421499_gene7586	1.004e-05	57.0	COG1522@1|root,COG1522@2|Bacteria,1MW1S@1224|Proteobacteria,2U77H@28211|Alphaproteobacteria,3JUEB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_74704_0	1278306.KB906915_gene1077	2.359e-06	60.0	COG0553@1|root,COG0553@2|Bacteria,3788I@32066|Fusobacteria	32066|Fusobacteria	L	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
YHH3_k127_7507415_0	997829.HMPREF1121_00213	0.0007694	53.0	COG1305@1|root,COG1305@2|Bacteria,4NFR8@976|Bacteroidetes,2FPAP@200643|Bacteroidia	976|Bacteroidetes	E	Transglutaminase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
YHH3_k127_7510802_0	1121422.AUMW01000009_gene3340	0.0	1034.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
YHH3_k127_7510802_2	572546.Arcpr_1361	7.907e-103	346.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
YHH3_k127_7510802_3	386456.JQKN01000001_gene1762	7.731e-78	268.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
YHH3_k127_7510802_6	1183377.Py04_1705	2.083e-24	105.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
YHH3_k127_7510802_4	399550.Smar_1019	1.531e-77	266.0	COG0090@1|root,arCOG04067@2157|Archaea,2XPW8@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
YHH3_k127_7510802_7	272844.PAB1522.1n	1.079e-10	63.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZXP@28890|Euryarchaeota,244NJ@183968|Thermococci	183968|Thermococci	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
YHH3_k127_7510802_1	573064.Mefer_0206	2.418e-124	411.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
YHH3_k127_7510802_5	1111728.ATYS01000001_gene2413	2.354e-70	247.0	COG2227@1|root,COG2227@2|Bacteria,1QYHT@1224|Proteobacteria,1T3QK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
YHH3_k127_7514020_1	82508.K1WTS5	1.017e-138	455.0	COG0114@1|root,KOG1317@2759|Eukaryota,38GHX@33154|Opisthokonta,3NTY2@4751|Fungi,3UYYY@5204|Basidiomycota,3VCP0@5234|Tremellales	4751|Fungi	C	Fumarase C C-terminus	FUM1	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0055114,GO:0070013,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	iMM904.YPL262W,iND750.YPL262W	FumaraseC_C,Lyase_1
YHH3_k127_7514020_0	877455.Metbo_2113	1.988e-201	641.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
YHH3_k127_7514020_2	386456.JQKN01000011_gene731	3.471e-64	228.0	COG0479@1|root,arCOG00962@2157|Archaea,2XSXW@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
YHH3_k127_7514020_3	880073.Calab_2008	6.527e-29	122.0	COG2189@1|root,COG2189@2|Bacteria,2NP0F@2323|unclassified Bacteria	2|Bacteria	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
YHH3_k127_7532768_3	768672.Desfe_1241	0.0001383	55.0	arCOG07477@1|root,arCOG07477@2157|Archaea,2XPP0@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7532768_1	5888.CAK72957	8.183e-35	139.0	KOG0084@1|root,KOG0084@2759|Eukaryota,3ZCZ3@5878|Ciliophora	2759|Eukaryota	U	Rab subfamily of small GTPases	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_7532768_0	398512.JQKC01000027_gene3915	2.726e-75	269.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,2480P@186801|Clostridia,3WRFA@541000|Ruminococcaceae	186801|Clostridia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
YHH3_k127_7532768_2	439481.Aboo_0620	9.559e-08	63.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
YHH3_k127_754038_2	366602.Caul_1811	3.115e-05	53.0	COG3055@1|root,COG3299@1|root,COG4447@1|root,COG3055@2|Bacteria,COG3299@2|Bacteria,COG4447@2|Bacteria,1P3E0@1224|Proteobacteria,2TUB6@28211|Alphaproteobacteria,2KJDB@204458|Caulobacterales	204458|Caulobacterales	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_754038_1	999630.TUZN_0697	1.517e-10	67.0	COG1545@1|root,arCOG01283@2157|Archaea,2XQEP@28889|Crenarchaeota	28889|Crenarchaeota	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
YHH3_k127_754038_0	1121430.JMLG01000002_gene1078	2.609e-100	340.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24FFI@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
YHH3_k127_7578973_1	1123325.JHUV01000010_gene1206	7.856e-14	80.0	COG3233@1|root,COG3233@2|Bacteria,2G517@200783|Aquificae	200783|Aquificae	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
YHH3_k127_7578973_2	693661.Arcve_1309	7.206e-13	70.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota	28890|Euryarchaeota	L	transcription factor (CBF NF-Y)	hstA	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
YHH3_k127_7578973_0	1041930.Mtc_0093	6.926e-84	292.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
YHH3_k127_7585677_0	515635.Dtur_1163	1.218e-65	238.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
YHH3_k127_760595_9	1170562.Cal6303_2232	0.0007536	51.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria	1117|Cyanobacteria	A	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
YHH3_k127_760595_4	471852.Tcur_4452	4.285e-55	207.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4EGFY@85012|Streptosporangiales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
YHH3_k127_760595_3	760568.Desku_2713	9.453e-56	203.0	COG5012@1|root,COG5012@2|Bacteria,1V33W@1239|Firmicutes,24J77@186801|Clostridia,266X4@186807|Peptococcaceae	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
YHH3_k127_760595_0	768710.DesyoDRAFT_1953	1.578e-118	399.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
YHH3_k127_760595_8	1056495.Calag_1361	0.0002865	53.0	COG1245@1|root,arCOG00187@2157|Archaea,2XPQF@28889|Crenarchaeota	28889|Crenarchaeota	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,Fer4_6,RLI
YHH3_k127_760595_1	768706.Desor_3837	3.203e-74	267.0	COG1600@1|root,COG1600@2|Bacteria,1V0B5@1239|Firmicutes,24FDD@186801|Clostridia,262G9@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM reductive dehalogenase	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4_16
YHH3_k127_760595_6	1047013.AQSP01000140_gene2511	8.882e-38	160.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
YHH3_k127_760595_7	1150474.JQJI01000067_gene116	5.227e-27	119.0	COG1180@1|root,COG1180@2|Bacteria,2GD8W@200918|Thermotogae	200918|Thermotogae	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
YHH3_k127_760595_2	269797.Mbar_A2503	2.668e-69	243.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
YHH3_k127_760595_5	933801.Ahos_2146	9.158e-42	160.0	COG0189@1|root,arCOG01589@2157|Archaea,2XQGE@28889|Crenarchaeota	28889|Crenarchaeota	H	RimK domain protein ATP-grasp	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
YHH3_k127_7642350_1	452637.Oter_4135	2.427e-08	64.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	MA20_16055	-	1.17.8.1,1.3.3.15,1.3.3.4,1.3.5.5,1.3.5.6	ko:K00231,ko:K00514,ko:K02293,ko:K09879,ko:K21677	ko00860,ko00906,ko01100,ko01110,map00860,map00906,map01100,map01110	M00097,M00121	R03222,R04178,R04786,R04787,R04798,R04800,R07510,R07511,R07541,R07560,R07857,R07858,R09652,R09653,R09654,R09656,R09658	RC00885,RC01214,RC01901,RC01958,RC01959,RC01965,RC03092,RC03093	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
YHH3_k127_7642350_0	635013.TherJR_0544	1.073e-52	200.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPG1@1239|Firmicutes,24C2Y@186801|Clostridia,263T4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
YHH3_k127_7655075_1	272562.CA_C0534	0.0005704	48.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,36DBV@31979|Clostridiaceae	186801|Clostridia	GT	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
YHH3_k127_7655075_0	1232410.KI421416_gene2685	5.82e-43	159.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WQX0@28221|Deltaproteobacteria,43W25@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K02617,ko:K08279	-	-	-	-	ko00000	-	-	-	Hexapep
YHH3_k127_7658906_3	673860.AciM339_1342	2.421e-11	77.0	COG1361@1|root,arCOG03439@1|root,arCOG07760@1|root,arCOG02080@2157|Archaea,arCOG03439@2157|Archaea,arCOG07760@2157|Archaea,2Y704@28890|Euryarchaeota,3F320@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CUB,Peptidase_C25,Propeptide_C25
YHH3_k127_7658906_2	1442599.JAAN01000033_gene1597	3.5e-27	129.0	COG1404@1|root,COG5640@1|root,COG1404@2|Bacteria,COG5640@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1X484@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the peptidase S8 family	-	GO:0005575,GO:0005576	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,PPC,P_proprotein,Peptidase_S8
YHH3_k127_7658906_5	243164.DET1403	0.000396	53.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
YHH3_k127_7658906_1	324925.Ppha_0114	5.279e-67	230.0	COG0432@1|root,COG0432@2|Bacteria,1FF33@1090|Chlorobi	1090|Chlorobi	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
YHH3_k127_7658906_4	446468.Ndas_0203	1.704e-06	52.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
YHH3_k127_7658906_0	498761.HM1_3055	4.187e-70	243.0	COG0675@1|root,COG0675@2|Bacteria,1TRNY@1239|Firmicutes,247T1@186801|Clostridia	186801|Clostridia	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_7666712_0	555779.Dthio_PD3581	1.637e-12	80.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,42Q3U@68525|delta/epsilon subdivisions,2WJ18@28221|Deltaproteobacteria,2M9ZX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7684308_1	698757.Pogu_1239	0.0008255	49.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2XSKE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Zinc finger TFIIB-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
YHH3_k127_7684308_0	1184251.TCELL_0650	1.131e-21	108.0	COG1602@1|root,arCOG04269@2157|Archaea,2XPMN@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Archaeal protein of	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
YHH3_k127_7684886_2	398767.Glov_1091	1.541e-27	128.0	COG5316@1|root,COG5316@2|Bacteria,1N0IJ@1224|Proteobacteria	1224|Proteobacteria	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
YHH3_k127_7684886_3	224325.AF_1515	1.136e-20	105.0	COG0642@1|root,arCOG06408@2157|Archaea,2Y7PX@28890|Euryarchaeota,247HY@183980|Archaeoglobi	183980|Archaeoglobi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
YHH3_k127_7684886_0	1150474.JQJI01000020_gene1568	2.472e-116	382.0	COG4608@1|root,COG4608@2|Bacteria,2GC91@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
YHH3_k127_7684886_1	1499967.BAYZ01000130_gene2588	1.315e-79	274.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
YHH3_k127_7695577_2	911045.PSE_p0134	1.446e-15	78.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
YHH3_k127_7695577_0	1385513.N780_05520	2.186e-29	123.0	2DNQ8@1|root,32YJ3@2|Bacteria,1VXNK@1239|Firmicutes,4HXD0@91061|Bacilli,2YAZG@289201|Pontibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7695577_1	43151.ADAC004327-PA	2.248e-29	124.0	KOG0080@1|root,KOG0080@2759|Eukaryota,38EZ7@33154|Opisthokonta,3BB89@33208|Metazoa,3CXE2@33213|Bilateria,41YZI@6656|Arthropoda,3SJKJ@50557|Insecta,44YPV@7147|Diptera,45D4S@7148|Nematocera	33208|Metazoa	U	Rab subfamily of small GTPases	RAB18	GO:0000166,GO:0001654,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0006810,GO:0006913,GO:0006996,GO:0007029,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009790,GO:0009792,GO:0009987,GO:0010256,GO:0012505,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0023052,GO:0031982,GO:0031984,GO:0032482,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034389,GO:0035556,GO:0036094,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048513,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051169,GO:0051170,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0060322,GO:0065007,GO:0071782,GO:0071786,GO:0071840,GO:0097159,GO:0097367,GO:0098827,GO:1901265,GO:1901363	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
YHH3_k127_7707131_0	1123284.KB899043_gene102	1.193e-59	214.0	COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli,26NSJ@186821|Sporolactobacillaceae	91061|Bacilli	IQ	KR domain	fabG1	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
YHH3_k127_7707131_2	1210908.HSB1_09030	1.609e-11	75.0	COG1413@1|root,arCOG02966@2157|Archaea,2XSWS@28890|Euryarchaeota,23SIB@183963|Halobacteria	183963|Halobacteria	C	COG1413 FOG HEAT repeat	cpcE2	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS
YHH3_k127_7707131_3	795797.C497_15733	1.641e-05	56.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,23S3N@183963|Halobacteria	183963|Halobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
YHH3_k127_7707131_1	1379698.RBG1_1C00001G0927	7.599e-20	94.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
YHH3_k127_7707131_4	580340.Tlie_1909	0.0001104	48.0	COG0457@1|root,COG0457@2|Bacteria	580340.Tlie_1909|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7712339_0	439235.Dalk_0164	1.487e-85	298.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
YHH3_k127_7715826_0	351160.LRC377	2.427e-77	282.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
YHH3_k127_7727690_0	304371.MCP_1660	2.667e-73	256.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
YHH3_k127_7727690_1	195522.BD01_0445	8.459e-16	88.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
YHH3_k127_7738314_0	368408.Tpen_1033	7.998e-15	80.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2XSKE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Zinc finger TFIIB-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
YHH3_k127_7738314_1	1410624.JNKK01000062_gene1076	4.358e-05	55.0	COG1594@1|root,COG1594@2|Bacteria,1UHVH@1239|Firmicutes,25E4D@186801|Clostridia,27UIJ@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7740745_1	891968.Anamo_1805	2.942e-57	213.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
YHH3_k127_7740745_0	386456.JQKN01000012_gene1041	5.985e-59	213.0	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,23NYF@183925|Methanobacteria	183925|Methanobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
YHH3_k127_7740745_4	1453498.LG45_15170	5.605e-42	157.0	COG5646@1|root,COG5646@2|Bacteria,4NSDH@976|Bacteroidetes,1I4HD@117743|Flavobacteriia,2NW8P@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
YHH3_k127_7740745_3	246969.TAM4_452	2.14e-45	170.0	COG1720@1|root,arCOG00761@2157|Archaea,2XY3D@28890|Euryarchaeota,2440R@183968|Thermococci	183968|Thermococci	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
YHH3_k127_7740745_8	1004149.AFOE01000014_gene1024	1.314e-06	60.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,1HXR1@117743|Flavobacteriia	976|Bacteroidetes	P	Ca2 Na antiporter	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
YHH3_k127_7740745_2	1114856.C496_20025	1.244e-45	177.0	COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,23RY4@183963|Halobacteria	183963|Halobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
YHH3_k127_7740745_6	391623.TERMP_00370	4.151e-14	75.0	arCOG07495@1|root,arCOG07495@2157|Archaea,2Y1A6@28890|Euryarchaeota,244Q6@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
YHH3_k127_7742319_0	760192.Halhy_1321	6.539e-76	267.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1IVS2@117747|Sphingobacteriia	976|Bacteroidetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
YHH3_k127_7742319_1	1122933.JNIY01000004_gene2155	1.182e-27	117.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,4F14F@85016|Cellulomonadaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
YHH3_k127_7751938_6	485913.Krac_3789	1.519e-05	55.0	COG0454@1|root,COG0456@2|Bacteria,2G8KY@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_7751938_0	521045.Kole_0740	8.736e-68	243.0	COG0778@1|root,COG0778@2|Bacteria,2GCST@200918|Thermotogae	200918|Thermotogae	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
YHH3_k127_7751938_4	1300350.DSW25_03140	1.848e-06	57.0	2C9CZ@1|root,33ZW9@2|Bacteria,1NZ55@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7751938_2	203275.BFO_1601	1.348e-23	110.0	2DPHF@1|root,33237@2|Bacteria,4P0MC@976|Bacteroidetes,2FZZF@200643|Bacteroidia	976|Bacteroidetes	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
YHH3_k127_7751938_5	861452.HMPREF9093_00749	5.273e-06	59.0	COG2271@1|root,COG2271@2|Bacteria,378KD@32066|Fusobacteria	32066|Fusobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
YHH3_k127_7751938_1	304371.MCP_2203	1.402e-25	117.0	COG1266@1|root,arCOG02766@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
YHH3_k127_7751938_3	1227499.C493_12774	1.142e-06	56.0	28HW9@1|root,2N5WN@2157|Archaea,2Y4HG@28890|Euryarchaeota,2407J@183963|Halobacteria	183963|Halobacteria	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
YHH3_k127_7751938_7	333138.LQ50_01980	0.0009325	46.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PrlF_antitoxin
YHH3_k127_7752131_1	103733.JNYO01000029_gene913	2.15e-07	60.0	2ACPI@1|root,312A5@2|Bacteria,2I99C@201174|Actinobacteria,4E7NG@85010|Pseudonocardiales	201174|Actinobacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
YHH3_k127_7752131_0	706587.Desti_2453	3.132e-71	246.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MQSA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
YHH3_k127_7765560_0	272844.PAB1490	1.809e-182	590.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,242P8@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
YHH3_k127_7765560_1	706587.Desti_3732	2.064e-146	474.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42PRI@68525|delta/epsilon subdivisions,2X5GA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
YHH3_k127_7765560_3	439481.Aboo_0134	4.229e-06	59.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
YHH3_k127_7765560_2	552811.Dehly_0886	3.163e-64	229.0	COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi,34DQQ@301297|Dehalococcoidia	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	lpd	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
YHH3_k127_778658_1	1131266.ARWQ01000001_gene1364	1.418e-155	502.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
YHH3_k127_778658_2	1183377.Py04_0692	7.532e-19	91.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
YHH3_k127_778658_0	1121289.JHVL01000013_gene1638	6.645e-217	682.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
YHH3_k127_7806517_6	374847.Kcr_1153	1.059e-11	70.0	COG4046@1|root,arCOG04181@2157|Archaea	2157|Archaea	S	DUF1512 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
YHH3_k127_7806517_5	1041930.Mtc_0490	3.409e-52	192.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,2N9PE@224756|Methanomicrobia	224756|Methanomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
YHH3_k127_7806517_4	604354.TSIB_1196	1.492e-52	197.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,242IM@183968|Thermococci	183968|Thermococci	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
YHH3_k127_7806517_7	604354.TSIB_1762	1.179e-11	71.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota,244BU@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
YHH3_k127_7806517_2	529709.PYCH_15040	3.552e-66	233.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,24333@183968|Thermococci	183968|Thermococci	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
YHH3_k127_7806517_0	671065.MetMK1DRAFT_00028710	3.044e-85	298.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
YHH3_k127_7806517_1	269797.Mbar_A1466	6.981e-81	278.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
YHH3_k127_7806517_3	573064.Mefer_1011	2.706e-64	229.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,23QKQ@183939|Methanococci	183939|Methanococci	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
YHH3_k127_7806517_8	273057.SSO6817	2.863e-10	62.0	COG4919@1|root,arCOG04293@2157|Archaea,2XR5C@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
YHH3_k127_7808316_0	579137.Metvu_1451	8.11e-91	302.0	COG0176@1|root,arCOG05061@2157|Archaea,2XTET@28890|Euryarchaeota,23Q23@183939|Methanococci	183939|Methanococci	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
YHH3_k127_7808316_1	1232410.KI421426_gene1403	3.088e-63	224.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,43TEV@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
YHH3_k127_7808316_2	272844.PAB1696	7.559e-34	134.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,243M3@183968|Thermococci	183968|Thermococci	E	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_7823204_0	1121430.JMLG01000026_gene7	0.0002881	46.0	COG0655@1|root,COG0655@2|Bacteria,1V5KZ@1239|Firmicutes,24II4@186801|Clostridia,265NY@186807|Peptococcaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_783200_0	273075.Ta0516m	9.072e-32	139.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,241M8@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
YHH3_k127_7854982_0	572478.Vdis_1836	4.343e-136	467.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
YHH3_k127_7854982_2	273068.TTE0283	4.118e-20	99.0	COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia,42G85@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
YHH3_k127_7854982_1	192952.MM_1958	3.171e-28	119.0	COG0537@1|root,arCOG00419@2157|Archaea,2XXWC@28890|Euryarchaeota,2NBIU@224756|Methanomicrobia	224756|Methanomicrobia	F	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
YHH3_k127_7854982_3	3067.XP_002951200.1	4.254e-07	62.0	KOG3861@1|root,KOG3861@2759|Eukaryota,37U36@33090|Viridiplantae,34HUZ@3041|Chlorophyta	3041|Chlorophyta	W	Intraflagellar transport protein IFT52	-	-	-	ko:K19681	-	-	-	-	ko00000,ko03036	-	-	-	ABC_transp_aux
YHH3_k127_7860149_1	7209.EFO20644.1	4.662e-24	114.0	COG0258@1|root,KOG2519@2759|Eukaryota,38GN8@33154|Opisthokonta,3BAYM@33208|Metazoa,3CX02@33213|Bilateria,40C19@6231|Nematoda,1KTMG@119089|Chromadorea	33208|Metazoa	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA	FEN1	GO:0000287,GO:0000723,GO:0000724,GO:0000725,GO:0000737,GO:0001654,GO:0003008,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004521,GO:0004523,GO:0004527,GO:0004529,GO:0004536,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006302,GO:0006308,GO:0006309,GO:0006310,GO:0006401,GO:0006725,GO:0006807,GO:0006915,GO:0006921,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007063,GO:0007275,GO:0007423,GO:0007610,GO:0007611,GO:0007613,GO:0008150,GO:0008152,GO:0008219,GO:0008309,GO:0008409,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009987,GO:0010564,GO:0010638,GO:0012501,GO:0016043,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016888,GO:0016891,GO:0016893,GO:0016895,GO:0017108,GO:0019439,GO:0019725,GO:0022402,GO:0022411,GO:0022616,GO:0030145,GO:0030262,GO:0031974,GO:0031981,GO:0032200,GO:0032201,GO:0032501,GO:0032502,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033260,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0042592,GO:0043010,GO:0043137,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044786,GO:0045787,GO:0045876,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0048256,GO:0048513,GO:0048518,GO:0048522,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050877,GO:0050890,GO:0050896,GO:0051128,GO:0051130,GO:0051276,GO:0051716,GO:0051726,GO:0051983,GO:0051984,GO:0060041,GO:0060249,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0071840,GO:0090068,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0097194,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576,GO:2001252	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
YHH3_k127_7860149_3	5297.GMQ_03140T0	0.0001124	53.0	COG0468@1|root,KOG1434@2759|Eukaryota,39J83@33154|Opisthokonta,3NVB0@4751|Fungi,3UY0V@5204|Basidiomycota,2YFIG@29000|Pucciniomycotina	4751|Fungi	L	KaiC	-	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000709,GO:0000724,GO:0000725,GO:0000730,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006311,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007130,GO:0007131,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010520,GO:0010564,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022414,GO:0022607,GO:0030554,GO:0031323,GO:0031974,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0033043,GO:0033554,GO:0034622,GO:0034641,GO:0035639,GO:0035822,GO:0035825,GO:0036094,GO:0040020,GO:0042148,GO:0042623,GO:0042802,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044877,GO:0045003,GO:0045132,GO:0045143,GO:0046483,GO:0048285,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051128,GO:0051171,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051445,GO:0051716,GO:0051726,GO:0051783,GO:0060255,GO:0060631,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070192,GO:0070193,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090735,GO:0097159,GO:0097367,GO:0098813,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1903046,GO:1905334,GO:2000241	-	ko:K10872,ko:K14545	ko03008,ko04113,map03008,map04113	-	-	-	ko00000,ko00001,ko03009,ko03400	-	-	-	HHH_5,Rad51
YHH3_k127_7860149_2	234267.Acid_1012	9.372e-05	53.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
YHH3_k127_7860149_0	186497.PF0677	5.678e-67	254.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,243RC@183968|Thermococci	183968|Thermococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
YHH3_k127_7871667_4	579137.Metvu_0823	3.255e-33	134.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,23QHW@183939|Methanococci	183939|Methanococci	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
YHH3_k127_7871667_1	456442.Mboo_0736	5.571e-51	191.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,2N99H@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
YHH3_k127_7871667_3	706587.Desti_5346	4.693e-42	167.0	COG0715@1|root,COG0715@2|Bacteria,1RHDX@1224|Proteobacteria,42V6G@68525|delta/epsilon subdivisions,2WRZJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	iAF987.Gmet_0996	NMT1_2
YHH3_k127_7871667_6	444158.MmarC6_0677	0.0002106	53.0	arCOG02497@1|root,arCOG03439@1|root,arCOG02497@2157|Archaea,arCOG03439@2157|Archaea,2XXWR@28890|Euryarchaeota,23RJF@183939|Methanococci	183939|Methanococci	S	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	NosD
YHH3_k127_7871667_2	1121459.AQXE01000010_gene1976	1.634e-48	179.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2M92T@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
YHH3_k127_7871667_5	926692.AZYG01000051_gene1857	4.259e-27	113.0	COG1144@1|root,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24NFD@186801|Clostridia,3WC0G@53433|Halanaerobiales	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
YHH3_k127_7871667_0	351627.Csac_1460	1.175e-122	404.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
YHH3_k127_7874099_0	1121405.dsmv_0775	7.652e-70	254.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
YHH3_k127_7874387_3	1117108.PAALTS15_22633	1.118e-13	85.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,26VXT@186822|Paenibacillaceae	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_7874387_4	926569.ANT_03760	4.649e-13	74.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
YHH3_k127_7874387_0	368407.Memar_1663	4.655e-42	162.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
YHH3_k127_7874387_2	1131266.ARWQ01000002_gene524	7.206e-15	83.0	COG1896@1|root,arCOG04311@2157|Archaea,41SQE@651137|Thaumarchaeota	651137|Thaumarchaeota	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
YHH3_k127_7874387_1	358396.C445_09855	7.104e-24	113.0	COG1744@1|root,arCOG00258@2157|Archaea,2XUKD@28890|Euryarchaeota,23SHY@183963|Halobacteria	183963|Halobacteria	S	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
YHH3_k127_7878032_1	1122947.FR7_2114	8.461e-13	70.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4H27J@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
YHH3_k127_7878032_0	1521187.JPIM01000167_gene1704	6.061e-27	124.0	COG0457@1|root,COG1404@1|root,COG0457@2|Bacteria,COG1404@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4,Kelch_5,Peptidase_S8
YHH3_k127_7883453_0	523845.AQXV01000048_gene613	5.908e-71	258.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,23QKV@183939|Methanococci	183939|Methanococci	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
YHH3_k127_7895829_0	267377.MMP1341	2.499e-07	63.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,23Q3I@183939|Methanococci	183939|Methanococci	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook
YHH3_k127_7896309_0	342949.PNA2_0807	2.666e-46	178.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
YHH3_k127_7913682_2	572546.Arcpr_1402	5.996e-06	56.0	COG0468@1|root,arCOG03154@1|root,arCOG00415@2157|Archaea,arCOG03154@2157|Archaea,2XT80@28890|Euryarchaeota,2463P@183980|Archaeoglobi	183980|Archaeoglobi	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
YHH3_k127_7913682_3	439481.Aboo_0624	9.747e-05	47.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y76C@28890|Euryarchaeota,3F3GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7913682_0	913865.DOT_0089	1.844e-33	133.0	COG0509@1|root,COG0509@2|Bacteria,1V9VC@1239|Firmicutes,24QN1@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
YHH3_k127_7913682_1	192952.MM_1314	2.131e-10	72.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
YHH3_k127_7923072_2	56780.SYN_01009	3.241e-23	102.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MR2C@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
YHH3_k127_7923072_0	1120973.AQXL01000116_gene322	9.522e-43	168.0	COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,4HEHP@91061|Bacilli,2797U@186823|Alicyclobacillaceae	91061|Bacilli	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
YHH3_k127_7923072_1	1123270.ATUR01000007_gene1352	5.924e-30	120.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2K0X2@204457|Sphingomonadales	204457|Sphingomonadales	I	Dehydrogenase	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
YHH3_k127_7955534_0	1227349.C170_24923	6.728e-12	74.0	COG0637@1|root,COG0637@2|Bacteria,1V1N8@1239|Firmicutes,4HI5Y@91061|Bacilli,274RE@186822|Paenibacillaceae	91061|Bacilli	S	phosphatase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
YHH3_k127_7973669_0	390874.Tpet_0568	1.069e-61	223.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
YHH3_k127_7975638_1	330779.Saci_0864	2.613e-10	61.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
YHH3_k127_7975638_0	694429.Pyrfu_1607	1.652e-96	332.0	COG1032@1|root,arCOG01356@2157|Archaea,2XPY0@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
YHH3_k127_7981199_1	1365176.N186_01240	3.54e-28	119.0	arCOG00299@1|root,arCOG00299@2157|Archaea,2XQKR@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_7981199_2	797209.ZOD2009_21592	2.596e-19	99.0	COG3608@1|root,arCOG02890@2157|Archaea,2XUN3@28890|Euryarchaeota,23TXV@183963|Halobacteria	183963|Halobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
YHH3_k127_7981199_0	1184251.TCELL_0880	1.514e-41	156.0	COG0495@1|root,arCOG00809@2157|Archaea,2XPP2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
YHH3_k127_7982105_1	1229909.NSED_00995	1.436e-24	106.0	COG3324@1|root,arCOG04946@2157|Archaea,41T3T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_7982105_0	386456.JQKN01000002_gene2765	2.638e-84	290.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
YHH3_k127_8015890_3	521011.Mpal_0293	2.772e-11	75.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,2N93Q@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8015890_1	743836.AYNA01000070_gene294	9.399e-27	121.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,36Y84@31993|Methylocystaceae	28211|Alphaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
YHH3_k127_8015890_0	688269.Theth_1455	1.609e-152	505.0	COG0449@1|root,COG0449@2|Bacteria,2GBY1@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
YHH3_k127_8015890_2	243232.MJ_1398	7.884e-12	68.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH3_k127_803018_3	102232.GLO73106DRAFT_00021270	1.171e-94	324.0	COG0675@1|root,COG0675@2|Bacteria,1G2YM@1117|Cyanobacteria	1117|Cyanobacteria	L	TIGRFAM transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_803018_15	70601.3258030	1.243e-13	75.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,244AW@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
YHH3_k127_803018_21	1298598.JCM21714_3212	0.0003834	46.0	COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,4HKC7@91061|Bacilli,4712X@74385|Gracilibacillus	91061|Bacilli	J	CRS1_YhbY	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
YHH3_k127_803018_6	342949.PNA2_1905	2.956e-54	194.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,242ZB@183968|Thermococci	183968|Thermococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
YHH3_k127_803018_12	192952.MM_0803	1.256e-23	104.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
YHH3_k127_803018_16	384616.Pisl_0442	2.309e-13	71.0	COG2167@1|root,arCOG04177@2157|Archaea,2XRC0@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
YHH3_k127_803018_14	579137.Metvu_1093	3.11e-14	78.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23R3K@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein L31e	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
YHH3_k127_803018_7	1220534.B655_1852	2.457e-47	177.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,23NZP@183925|Methanobacteria	183925|Methanobacteria	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
YHH3_k127_803018_18	272844.PAB7388	1.051e-11	67.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,244JC@183968|Thermococci	183968|Thermococci	J	rRNA binding	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
YHH3_k127_803018_17	1041930.Mtc_0441	7.16e-12	72.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
YHH3_k127_803018_2	523850.TON_0592	6.242e-96	323.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
YHH3_k127_803018_0	1536775.H70737_28125	4.298e-107	356.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H9X8@91061|Bacilli,26S8W@186822|Paenibacillaceae	91061|Bacilli	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
YHH3_k127_803018_10	797209.ZOD2009_21917	2.042e-35	147.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23SW4@183963|Halobacteria	183963|Halobacteria	G	Belongs to the carbohydrate kinase PfkB family	suk	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
YHH3_k127_803018_1	529709.PYCH_18150	3.087e-103	347.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,242PW@183968|Thermococci	183968|Thermococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
YHH3_k127_803018_20	591019.Shell_1385	9.178e-06	50.0	COG2443@1|root,arCOG02204@2157|Archaea	2157|Archaea	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
YHH3_k127_803018_11	304371.MCP_2134	1.88e-29	126.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2N9MV@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
YHH3_k127_803018_8	1236689.MMALV_00450	5.356e-46	171.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,3F2N7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
YHH3_k127_803018_9	1041930.Mtc_1421	8.169e-45	170.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,2N9HV@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
YHH3_k127_803018_4	797209.ZOD2009_07774	3.585e-63	229.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23T1A@183963|Halobacteria	183963|Halobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
YHH3_k127_803018_13	453591.Igni_0451	1.67e-23	102.0	COG2058@1|root,arCOG04287@2157|Archaea,2XQSC@28889|Crenarchaeota	28889|Crenarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
YHH3_k127_803018_5	1121468.AUBR01000054_gene1448	5.319e-63	226.0	COG0123@1|root,COG0123@2|Bacteria,1V066@1239|Firmicutes,2483W@186801|Clostridia	186801|Clostridia	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
YHH3_k127_803018_19	1145276.T479_11235	2.478e-09	64.0	COG2318@1|root,COG2318@2|Bacteria,1V5WQ@1239|Firmicutes,4HHAG@91061|Bacilli,3IXZG@400634|Lysinibacillus	91061|Bacilli	S	Damage-inducible protein DinB	-	-	-	-	-	-	-	-	-	-	-	-	DinB
YHH3_k127_8072945_1	1347392.CCEZ01000075_gene3032	2.653e-54	201.0	COG0384@1|root,COG0384@2|Bacteria,1TRAF@1239|Firmicutes,25D2F@186801|Clostridia,36DVZ@31979|Clostridiaceae	186801|Clostridia	S	Phenazine biosynthesis protein, PhzF family	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
YHH3_k127_8072945_0	342949.PNA2_0765	3.229e-77	276.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_807635_6	646529.Desaci_2459	2.975e-56	200.0	COG0242@1|root,COG0242@2|Bacteria,1V41Q@1239|Firmicutes,24I9S@186801|Clostridia	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
YHH3_k127_807635_3	304371.MCP_0044	3.193e-101	337.0	COG1145@1|root,arCOG02189@2157|Archaea,2XX12@28890|Euryarchaeota	28890|Euryarchaeota	C	ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_807635_4	342949.PNA2_1018	3.023e-97	333.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUJT@28890|Euryarchaeota,245AW@183968|Thermococci	183968|Thermococci	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
YHH3_k127_807635_1	579137.Metvu_0779	3.152e-116	387.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,23PZZ@183939|Methanococci	183939|Methanococci	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
YHH3_k127_807635_0	59894.ENSFALP00000007683	1.116e-121	405.0	COG0148@1|root,KOG2670@2759|Eukaryota,38C66@33154|Opisthokonta,3BE2S@33208|Metazoa,3CU4G@33213|Bilateria,480BN@7711|Chordata,48V1P@7742|Vertebrata,4GU7P@8782|Aves	33208|Metazoa	G	Enolase, N-terminal domain	ENO1	GO:0000015,GO:0000122,GO:0000976,GO:0000977,GO:0000981,GO:0000982,GO:0001012,GO:0001067,GO:0001078,GO:0001227,GO:0001558,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006355,GO:0006357,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006937,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009615,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009968,GO:0009986,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010562,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010648,GO:0010755,GO:0010756,GO:0010941,GO:0010954,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0019899,GO:0023051,GO:0023057,GO:0030162,GO:0030308,GO:0030808,GO:0030810,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032270,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040008,GO:0042802,GO:0042803,GO:0042866,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043565,GO:0044057,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044448,GO:0044464,GO:0045862,GO:0045892,GO:0045926,GO:0045933,GO:0045934,GO:0045935,GO:0045937,GO:0045981,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051186,GO:0051188,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051704,GO:0051707,GO:0055086,GO:0055114,GO:0060255,GO:0060548,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0062012,GO:0062013,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0080135,GO:0090257,GO:0090407,GO:0097159,GO:0099568,GO:0099738,GO:0140110,GO:1900037,GO:1900038,GO:1900371,GO:1900373,GO:1900542,GO:1900544,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494,GO:1902531,GO:1902532,GO:1902679,GO:1903297,GO:1903298,GO:1903317,GO:1903319,GO:1903506,GO:1903507,GO:1903578,GO:1903580,GO:1990837,GO:2000112,GO:2000113,GO:2001141,GO:2001169,GO:2001171,GO:2001233,GO:2001234,GO:2001242,GO:2001243	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
YHH3_k127_807635_2	1219626.HMPREF1639_03450	2.745e-110	372.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,25QHI@186804|Peptostreptococcaceae	186801|Clostridia	G	Pyruvate kinase	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
YHH3_k127_807635_5	591019.Shell_0525	7.188e-77	268.0	COG0451@1|root,arCOG01369@2157|Archaea,2XPYT@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
YHH3_k127_807635_8	682795.AciX8_0249	9.479e-08	65.0	COG1216@1|root,COG1216@2|Bacteria,3Y6HJ@57723|Acidobacteria,2JK7H@204432|Acidobacteriia	204432|Acidobacteriia	S	Pfam:DUF2029	-	-	-	-	-	-	-	-	-	-	-	-	GT87
YHH3_k127_807635_7	1444306.JFZC01000084_gene1525	5.551e-13	81.0	COG0438@1|root,COG0438@2|Bacteria,1TQRQ@1239|Firmicutes,4HBT5@91061|Bacilli	91061|Bacilli	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
YHH3_k127_8096374_5	1239962.C943_02582	3.126e-10	70.0	COG2234@1|root,COG2234@2|Bacteria,4NENF@976|Bacteroidetes,47JMS@768503|Cytophagia	976|Bacteroidetes	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
YHH3_k127_8096374_3	1042877.GQS_07780	1.448e-37	160.0	COG0286@1|root,arCOG04814@1|root,arCOG02632@2157|Archaea,arCOG04814@2157|Archaea,2XVYV@28890|Euryarchaeota	28890|Euryarchaeota	V	COG1002 Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
YHH3_k127_8096374_4	490899.DKAM_1384	1.995e-30	128.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
YHH3_k127_8096374_0	933801.Ahos_0647	2.883e-44	166.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
YHH3_k127_8096374_1	579137.Metvu_0860	4.421e-40	160.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23QKP@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
YHH3_k127_8096374_2	224325.AF_2238	1.199e-38	145.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,245PX@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
YHH3_k127_8111747_0	1150474.JQJI01000057_gene963	9.854e-45	167.0	COG0383@1|root,COG0383@2|Bacteria,2GCGE@200918|Thermotogae	200918|Thermotogae	G	PFAM glycoside hydrolase family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
YHH3_k127_8111747_2	1168065.DOK_17715	2.31e-24	103.0	COG0446@1|root,COG1773@1|root,COG0446@2|Bacteria,COG1773@2|Bacteria,1NR3M@1224|Proteobacteria,1RQ07@1236|Gammaproteobacteria,1J4MC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	rubB	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Rubredoxin
YHH3_k127_8111747_4	398720.MED217_14925	9.377e-08	59.0	COG0526@1|root,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1I2TH@117743|Flavobacteriia,2XJEV@283735|Leeuwenhoekiella	976|Bacteroidetes	CO	Thioredoxin	txn	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
YHH3_k127_8111747_3	5759.rna_EHI_122870-1	7.288e-23	105.0	COG1100@1|root,KOG0087@2759|Eukaryota,3XFEK@554915|Amoebozoa	554915|Amoebozoa	U	Rab subfamily of small GTPases	-	-	-	-	-	-	-	-	-	-	-	-	Ras
YHH3_k127_8111747_1	195522.BD01_0626	1.448e-28	116.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_8119190_0	1122927.KB895414_gene5054	9.538e-103	344.0	COG0178@1|root,COG0178@2|Bacteria,1UYEG@1239|Firmicutes,4HU19@91061|Bacilli,26TRV@186822|Paenibacillaceae	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
YHH3_k127_816018_6	1121930.AQXG01000001_gene1401	1.427e-11	72.0	2DR9X@1|root,33AUW@2|Bacteria	2|Bacteria	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
YHH3_k127_816018_4	1229783.C273_00375	3.026e-19	93.0	COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,4HJUY@91061|Bacilli,4H1Q7@90964|Staphylococcaceae	91061|Bacilli	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
YHH3_k127_816018_2	273063.STK_12960	5.809e-40	152.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
YHH3_k127_816018_0	386456.JQKN01000002_gene2741	1.739e-49	188.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
YHH3_k127_816018_5	410358.Mlab_0774	4.513e-15	81.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,2NA00@224756|Methanomicrobia	224756|Methanomicrobia	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
YHH3_k127_816018_1	304371.MCP_0732	2.539e-49	179.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
YHH3_k127_816018_3	868131.MSWAN_0515	2.3e-21	102.0	COG1233@1|root,arCOG01524@2157|Archaea,2XSYN@28890|Euryarchaeota	28890|Euryarchaeota	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
YHH3_k127_8205663_0	5286.M7WR93	2.047e-07	62.0	COG0468@1|root,KOG1564@2759|Eukaryota,38E66@33154|Opisthokonta,3NY37@4751|Fungi,3V1KP@5204|Basidiomycota,2YEN7@29000|Pucciniomycotina	4751|Fungi	L	Rad51	rhp57	GO:0000003,GO:0000150,GO:0000217,GO:0000280,GO:0000400,GO:0000707,GO:0000722,GO:0000723,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0022414,GO:0022607,GO:0030491,GO:0032200,GO:0032991,GO:0033061,GO:0033062,GO:0033063,GO:0033170,GO:0033554,GO:0034622,GO:0034641,GO:0035825,GO:0035861,GO:0042148,GO:0042592,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0045003,GO:0046483,GO:0046982,GO:0046983,GO:0048285,GO:0050896,GO:0051276,GO:0051321,GO:0051716,GO:0060249,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090734,GO:0090735,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046	-	ko:K10880,ko:K10958	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	Rad51
YHH3_k127_8215570_0	877455.Metbo_0683	1.279e-47	184.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,23NSR@183925|Methanobacteria	183925|Methanobacteria	S	methanogenesis marker protein 2	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
YHH3_k127_8215570_2	410359.Pcal_0042	1.33e-06	54.0	arCOG05464@1|root,arCOG05464@2157|Archaea,2XR3S@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8215570_1	1459636.NTE_01764	9.403e-46	172.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
YHH3_k127_8238170_0	358823.DF19_21890	8.968e-05	50.0	COG0500@1|root,COG2226@2|Bacteria,2GJUF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
YHH3_k127_8243825_0	304371.MCP_2998	7.113e-77	278.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
YHH3_k127_8243825_1	933801.Ahos_1125	2.927e-21	101.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
YHH3_k127_8253803_0	667014.Thein_1369	4.726e-132	431.0	COG0115@1|root,COG0115@2|Bacteria,2GHRV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
YHH3_k127_8253803_2	589924.Ferp_2333	1.254e-35	143.0	COG0437@1|root,arCOG01500@2157|Archaea	2157|Archaea	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_6
YHH3_k127_8253803_1	604354.TSIB_1009	6.362e-75	260.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,242U3@183968|Thermococci	183968|Thermococci	C	aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_8256915_2	553184.ATORI0001_0985	0.000752	48.0	COG2020@1|root,COG2020@2|Bacteria,2IIH0@201174|Actinobacteria	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
YHH3_k127_8256915_0	318464.IO99_13015	1.717e-112	382.0	COG2317@1|root,COG2317@2|Bacteria,1TPS6@1239|Firmicutes,249NK@186801|Clostridia,36F32@31979|Clostridiaceae	186801|Clostridia	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
YHH3_k127_8256915_1	1121405.dsmv_1706	7.04e-39	158.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2MIE6@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH3_k127_8260717_1	485916.Dtox_1591	2.506e-34	142.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
YHH3_k127_8260717_0	96561.Dole_0145	9.022e-50	183.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295,PEMT
YHH3_k127_8275039_0	720554.Clocl_3963	9.847e-111	374.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3WK9K@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
YHH3_k127_8275039_2	997346.HMPREF9374_2118	2.359e-12	74.0	COG2318@1|root,COG2318@2|Bacteria,1V6FD@1239|Firmicutes,4HJI8@91061|Bacilli,27C7I@186824|Thermoactinomycetaceae	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
YHH3_k127_8275039_1	406124.ACPC01000047_gene1729	1.212e-70	253.0	COG3616@1|root,COG3616@2|Bacteria,1TSES@1239|Firmicutes,4HA93@91061|Bacilli,1ZQJR@1386|Bacillus	91061|Bacilli	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
YHH3_k127_8286334_0	635013.TherJR_2724	4.175e-114	388.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,249BI@186801|Clostridia,261AA@186807|Peptococcaceae	186801|Clostridia	G	TIGRFAM glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
YHH3_k127_8290011_0	1094980.Mpsy_1403	7.209e-66	237.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
YHH3_k127_8290011_2	679926.Mpet_0288	3.023e-21	101.0	arCOG02385@1|root,arCOG03567@1|root,arCOG06516@1|root,arCOG02385@2157|Archaea,arCOG03567@2157|Archaea,arCOG06516@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9,Response_reg
YHH3_k127_8290011_1	767817.Desgi_1718	6.077e-44	169.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,24A0M@186801|Clostridia,2626X@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
YHH3_k127_8298546_6	521045.Kole_1186	3.843e-28	121.0	COG1670@1|root,COG1670@2|Bacteria,2GCZ2@200918|Thermotogae	200918|Thermotogae	J	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
YHH3_k127_8298546_0	926569.ANT_18080	2.187e-300	934.0	COG0021@1|root,COG0021@2|Bacteria,2G63Z@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
YHH3_k127_8298546_4	357809.Cphy_1628	2.145e-85	291.0	COG1853@1|root,COG1853@2|Bacteria,1UZS7@1239|Firmicutes,24FF8@186801|Clostridia	186801|Clostridia	S	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8298546_7	906968.Trebr_1157	2.976e-27	116.0	COG3871@1|root,COG3871@2|Bacteria,2J9F1@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
YHH3_k127_8298546_5	1469948.JPNB01000002_gene2784	1.216e-33	134.0	COG1846@1|root,COG1846@2|Bacteria,1V8KT@1239|Firmicutes,24B99@186801|Clostridia,36KPX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
YHH3_k127_8298546_2	1499967.BAYZ01000009_gene5378	4.698e-103	342.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
YHH3_k127_8298546_9	1379698.RBG1_1C00001G0743	7.64e-10	66.0	COG2318@1|root,COG2318@2|Bacteria,2NRHG@2323|unclassified Bacteria	2|Bacteria	S	DinB superfamily	dinB	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	DinB
YHH3_k127_8298546_10	1449048.JQKU01000013_gene3289	1.124e-07	62.0	COG3393@1|root,COG3393@2|Bacteria,2GMQC@201174|Actinobacteria,23D6M@1762|Mycobacteriaceae	201174|Actinobacteria	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FR47
YHH3_k127_8298546_3	649747.HMPREF0083_00854	1.959e-91	311.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4HCUU@91061|Bacilli,275PQ@186822|Paenibacillaceae	91061|Bacilli	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
YHH3_k127_8298546_8	529709.PYCH_15810	6.494e-23	106.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,243SX@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
YHH3_k127_8298546_1	368407.Memar_2034	3.244e-112	380.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8305894_0	321327.CYA_1900	2.706e-32	136.0	COG0467@1|root,COG0467@2|Bacteria,1G0KY@1117|Cyanobacteria,1GZB7@1129|Synechococcus	1117|Cyanobacteria	F	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	kaiC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0009605,GO:0009649,GO:0009966,GO:0009987,GO:0010646,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0023051,GO:0036211,GO:0042752,GO:0042754,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0048511,GO:0048519,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070297,GO:0071704,GO:1901564,GO:1902531	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
YHH3_k127_8316759_3	316067.Geob_0814	1.545e-09	65.0	COG1361@1|root,COG1520@1|root,COG1657@1|root,COG4257@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1657@2|Bacteria,COG4257@2|Bacteria,COG4733@2|Bacteria,1QYWJ@1224|Proteobacteria,43CDC@68525|delta/epsilon subdivisions,2X7P6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
YHH3_k127_8316759_1	1123276.KB893262_gene4089	9.738e-57	207.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
YHH3_k127_8316759_4	5759.rna_EHI_158150-1	0.000159	53.0	KOG1703@1|root,KOG1703@2759|Eukaryota,3XACX@554915|Amoebozoa	554915|Amoebozoa	TZ	Zinc-binding domain present in Lin-11, Isl-1, Mec-3.	-	-	-	-	-	-	-	-	-	-	-	-	LIM
YHH3_k127_8316759_0	368408.Tpen_1035	1.906e-72	254.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
YHH3_k127_8316759_2	269797.Mbar_A3142	1.976e-24	110.0	COG1234@1|root,arCOG00500@2157|Archaea,2XTUD@28890|Euryarchaeota,2NAES@224756|Methanomicrobia	224756|Methanomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
YHH3_k127_8322398_0	1123054.KB907711_gene361	5.37e-29	130.0	COG1404@1|root,COG3266@1|root,COG1404@2|Bacteria,COG3266@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,1WXY7@135613|Chromatiales	135613|Chromatiales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
YHH3_k127_832370_0	192952.MM_3157	1.714e-60	221.0	COG1680@1|root,arCOG00771@2157|Archaea	2157|Archaea	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1202	Beta-lactamase
YHH3_k127_8337933_1	865861.AZSU01000002_gene2618	5.276e-117	391.0	COG0863@1|root,COG0863@2|Bacteria,1TPR7@1239|Firmicutes,24A3P@186801|Clostridia,36E8V@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
YHH3_k127_8337933_5	1041930.Mtc_1611	3.351e-09	60.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota,2NBEM@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH3_k127_8337933_0	391623.TERMP_00751	3.455e-132	436.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,242Q1@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K22503	ko00970,map00970	M00359	R05577	RC00055,RC00523	ko00000,ko00001,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
YHH3_k127_8337933_4	3218.PP1S141_146V6.1	1.509e-09	68.0	KOG3341@1|root,KOG3341@2759|Eukaryota,37PQ2@33090|Viridiplantae,3GD3U@35493|Streptophyta	35493|Streptophyta	U	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs	-	GO:0000814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0007034,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010008,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016192,GO:0016197,GO:0019538,GO:0019941,GO:0030163,GO:0031090,GO:0031410,GO:0031982,GO:0032509,GO:0032511,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036452,GO:0042886,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043328,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045324,GO:0046907,GO:0051179,GO:0051234,GO:0051603,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:1901564,GO:1901565,GO:1901575	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
YHH3_k127_8337933_6	263815.XP_007873148.1	1.575e-05	55.0	KOG4068@1|root,KOG4068@2759|Eukaryota,39S7B@33154|Opisthokonta,3P2R4@4751|Fungi,3QWVJ@4890|Ascomycota,3MCY0@451866|Taphrinomycotina	4751|Fungi	U	ESCRT II complex subunit Vps25	-	GO:0000429,GO:0000430,GO:0000433,GO:0000814,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0006355,GO:0006357,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0007034,GO:0007154,GO:0007584,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010008,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016192,GO:0016197,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0030163,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031982,GO:0032509,GO:0032511,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036452,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0042886,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043328,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045013,GO:0045014,GO:0045184,GO:0045324,GO:0045892,GO:0045934,GO:0045990,GO:0046015,GO:0046618,GO:0046907,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0061986,GO:0061987,GO:0065007,GO:0070727,GO:0070887,GO:0071496,GO:0071702,GO:0071704,GO:0071705,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:1904669,GO:2000112,GO:2000113,GO:2001141	-	ko:K12189	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	ESCRT-II
YHH3_k127_8337933_3	337075.U4LEU2	1.686e-71	256.0	KOG0739@1|root,KOG0739@2759|Eukaryota,38D1Q@33154|Opisthokonta,3NUSN@4751|Fungi,3QKW5@4890|Ascomycota	4751|Fungi	O	Belongs to the AAA ATPase family	VPS4	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005783,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006900,GO:0006914,GO:0006996,GO:0006997,GO:0006998,GO:0007032,GO:0007033,GO:0007034,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0009056,GO:0009057,GO:0009306,GO:0009405,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016125,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019941,GO:0022607,GO:0030163,GO:0030447,GO:0030448,GO:0030554,GO:0031410,GO:0031982,GO:0032507,GO:0032509,GO:0032511,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0033036,GO:0033365,GO:0034067,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042802,GO:0042803,GO:0042886,GO:0043162,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043328,GO:0043632,GO:0043933,GO:0044085,GO:0044182,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045053,GO:0045184,GO:0045185,GO:0045324,GO:0046903,GO:0046907,GO:0046983,GO:0050896,GO:0051179,GO:0051234,GO:0051235,GO:0051259,GO:0051260,GO:0051603,GO:0051641,GO:0051649,GO:0051651,GO:0051704,GO:0051716,GO:0061024,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0070676,GO:0070727,GO:0070887,GO:0071241,GO:0071248,GO:0071285,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0097159,GO:0097367,GO:0097708,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901615	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
YHH3_k127_8337933_2	1042877.GQS_08250	2.046e-72	259.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
YHH3_k127_8343680_1	304371.MCP_2392	5.059e-40	151.0	arCOG05253@1|root,arCOG05253@2157|Archaea,2Y4YF@28890|Euryarchaeota,2NB34@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8343680_3	1244531.CIG1485E_1520	4.043e-11	68.0	arCOG09714@1|root,316P9@2|Bacteria,1RKCF@1224|Proteobacteria,42T0T@68525|delta/epsilon subdivisions,2YQ4R@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	COG NOG16854 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8343680_2	1167006.UWK_01352	1.076e-11	70.0	2E8UW@1|root,3335A@2|Bacteria,1N8I8@1224|Proteobacteria,42TGA@68525|delta/epsilon subdivisions,2WQAG@28221|Deltaproteobacteria,2MKHK@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8343680_0	1266925.JHVX01000001_gene2544	1.05e-81	275.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,372T7@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Alpha-amylase domain	aglA	-	3.2.1.10,3.2.1.20	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01718,R01791,R06087,R06088,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
YHH3_k127_8362225_1	273116.14324340	2.574e-40	156.0	COG2189@1|root,arCOG00108@2157|Archaea,2XUPX@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA methylase N-4 N-6	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
YHH3_k127_8362225_2	444157.Tneu_0050	1.158e-14	77.0	COG1383@1|root,arCOG01885@2157|Archaea,2XRGM@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
YHH3_k127_8362225_0	591019.Shell_1131	3.815e-97	329.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
YHH3_k127_836305_0	660470.Theba_2511	1.25e-94	318.0	COG1233@1|root,COG1233@2|Bacteria,2GDP7@200918|Thermotogae	200918|Thermotogae	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
YHH3_k127_8366407_1	644282.Deba_0138	2.217e-118	392.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
YHH3_k127_8366407_0	644282.Deba_0138	2.514e-215	683.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
YHH3_k127_8366407_3	388467.A19Y_3420	1.019e-08	63.0	COG0467@1|root,COG0467@2|Bacteria,1G0KY@1117|Cyanobacteria,1H96J@1150|Oscillatoriales	1117|Cyanobacteria	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	kaiC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0009605,GO:0009649,GO:0009966,GO:0009987,GO:0010646,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0023051,GO:0036211,GO:0042752,GO:0042754,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0048511,GO:0048519,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070297,GO:0071704,GO:1901564,GO:1902531	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
YHH3_k127_8366407_2	177437.HRM2_43040	4.194e-17	94.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,2MJS3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
YHH3_k127_8371965_0	944565.HMPREF9127_0768	2.152e-17	90.0	290DM@1|root,2ZN2Z@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH3_k127_8380412_0	573413.Spirs_3146	6.717e-210	667.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
YHH3_k127_8386318_0	665959.HMPREF1013_03352	1.436e-09	68.0	COG3714@1|root,COG3714@2|Bacteria,1V3FV@1239|Firmicutes,4HGBW@91061|Bacilli,1ZHBP@1386|Bacillus	91061|Bacilli	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
YHH3_k127_840002_1	1233951.IO90_01130	2.898e-05	57.0	COG1541@1|root,COG1541@2|Bacteria,4NGRR@976|Bacteroidetes,1HZ2J@117743|Flavobacteriia,3HGQ7@358033|Chryseobacterium	976|Bacteroidetes	H	AMP-binding enzyme	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
YHH3_k127_840002_0	1343739.PAP_07605	1.664e-21	94.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
YHH3_k127_8416405_1	5808.XP_002140306.1	1.364e-22	102.0	KOG0084@1|root,KOG0084@2759|Eukaryota,3YA22@5794|Apicomplexa,3YM2P@5796|Coccidia	5794|Apicomplexa	U	Ras family	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_8416405_0	4513.MLOC_69657.2	4.073e-26	114.0	COG1100@1|root,KOG0087@2759|Eukaryota,37N1I@33090|Viridiplantae,3GF78@35493|Streptophyta,3KPZV@4447|Liliopsida,3IG73@38820|Poales	35493|Streptophyta	U	Ras family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005886,GO:0016020,GO:0031090,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0071944,GO:0098588,GO:0098805	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_8416405_2	497321.C664_14873	1.547e-07	60.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,2KVV2@206389|Rhodocyclales	206389|Rhodocyclales	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
YHH3_k127_8429241_1	1136138.JH604623_gene3195	9.845e-09	66.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	chemotaxis, protein	pctC	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
YHH3_k127_8429241_0	1123288.SOV_2c01240	3.453e-13	84.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H6NB@909932|Negativicutes	909932|Negativicutes	NT	SMART chemotaxis sensory transducer, histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
YHH3_k127_8430940_25	4533.OB01G23550.1	0.000213	46.0	2D4D8@1|root,2SURN@2759|Eukaryota,3810X@33090|Viridiplantae,3GQVD@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8430940_15	596152.DesU5LDRAFT_2681	1.267e-22	100.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8430940_11	748727.CLJU_c08780	8.642e-36	146.0	COG0084@1|root,COG0084@2|Bacteria,1V7QH@1239|Firmicutes,25CNP@186801|Clostridia,36WYE@31979|Clostridiaceae	186801|Clostridia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
YHH3_k127_8430940_2	1379698.RBG1_1C00001G0798	1.215e-138	472.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	HEAT_2,Peptidase_M1
YHH3_k127_8430940_23	1056495.Calag_0281	5.778e-09	65.0	arCOG13715@1|root,arCOG13715@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8430940_20	1056495.Calag_0282	1.046e-13	78.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	HTH_45
YHH3_k127_8430940_3	1047013.AQSP01000125_gene2640	3.761e-73	261.0	COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria	2|Bacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1,Sugar_tr
YHH3_k127_8430940_18	1333523.L593_01895	1.501e-15	81.0	COG3439@1|root,arCOG02761@2157|Archaea,2XWKE@28890|Euryarchaeota,23V92@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
YHH3_k127_8430940_10	1305836.AXVE01000001_gene2681	2.529e-41	162.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4IQCJ@91061|Bacilli	91061|Bacilli	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH3_k127_8430940_21	1121012.AUKX01000039_gene3173	2.052e-13	77.0	COG1764@1|root,COG1764@2|Bacteria,4PK2I@976|Bacteroidetes,1I3KT@117743|Flavobacteriia,23HPR@178469|Arenibacter	976|Bacteroidetes	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
YHH3_k127_8430940_12	330214.NIDE3895	2.261e-27	117.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
YHH3_k127_8430940_0	1459636.NTE_03216	1.434e-241	771.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
YHH3_k127_8430940_6	386456.JQKN01000002_gene2749	2.112e-50	187.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,23NRI@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
YHH3_k127_8430940_19	192952.MM_2352	1.061e-14	77.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y49G@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8430940_1	671143.DAMO_2750	2.043e-161	526.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2NNNK@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase X family	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
YHH3_k127_8430940_8	596154.Alide2_3505	1.261e-46	181.0	COG0407@1|root,COG0407@2|Bacteria,1NDUE@1224|Proteobacteria,2VZ7U@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
YHH3_k127_8430940_4	1120973.AQXL01000084_gene2777	1.127e-70	254.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,4HBTF@91061|Bacilli,2784E@186823|Alicyclobacillaceae	91061|Bacilli	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	iYO844.BSU29710	Hist_deacetyl
YHH3_k127_8430940_13	86416.Clopa_1099	6.036e-25	112.0	COG0500@1|root,COG2226@2|Bacteria,1UI7M@1239|Firmicutes,24E0D@186801|Clostridia,36N6N@31979|Clostridiaceae	186801|Clostridia	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
YHH3_k127_8430940_7	485914.Hmuk_1186	2.913e-47	190.0	COG1073@1|root,arCOG01661@2157|Archaea	2157|Archaea	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
YHH3_k127_8430940_16	1075090.GOAMR_20_01090	4.358e-22	107.0	2ERKW@1|root,33J6D@2|Bacteria,2I7F1@201174|Actinobacteria,4GGVG@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8430940_14	1223545.GS4_07_01310	2.024e-23	113.0	2DV17@1|root,33TH7@2|Bacteria,2GN6H@201174|Actinobacteria,4GFZ7@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8430940_17	1828.JOKB01000066_gene4737	2.706e-17	86.0	2EX84@1|root,33QIW@2|Bacteria,2ICDC@201174|Actinobacteria	201174|Actinobacteria	S	PEP-utilising enzyme, mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers
YHH3_k127_8430940_5	1128398.Curi_c06920	8.61e-57	211.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,268N0@186813|unclassified Clostridiales	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
YHH3_k127_8430940_24	1487923.DP73_06490	2.667e-06	54.0	COG1146@1|root,COG1146@2|Bacteria,1W2AI@1239|Firmicutes,25709@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
YHH3_k127_8430940_9	880072.Desac_2119	1.164e-42	168.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria,2MRI3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_8433378_1	309799.DICTH_1311	1.163e-63	224.0	COG0299@1|root,COG0299@2|Bacteria	2|Bacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2,6.3.2.6,6.3.4.13	ko:K11175,ko:K13713	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04144,R04325,R04326,R04591	RC00026,RC00064,RC00090,RC00162,RC00166,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
YHH3_k127_8433378_0	523845.AQXV01000047_gene780	3.183e-77	276.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23Q7H@183939|Methanococci	183939|Methanococci	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
YHH3_k127_8433378_2	572546.Arcpr_1226	1.555e-11	66.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,245ZA@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
YHH3_k127_844031_1	1158338.JNLJ01000001_gene73	5.684e-24	105.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
YHH3_k127_844031_0	391623.TERMP_00459	4.248e-79	275.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
YHH3_k127_8453036_0	880072.Desac_1145	4.7e-201	653.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
YHH3_k127_8453036_2	70601.3258122	0.0003551	50.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota,243TB@183968|Thermococci	183968|Thermococci	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
YHH3_k127_8453036_1	644076.SCH4B_2927	8.206e-59	214.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TRQ5@28211|Alphaproteobacteria,4NA6D@97050|Ruegeria	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepE	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
YHH3_k127_8488294_0	935948.KE386494_gene394	2.466e-23	109.0	COG3568@1|root,COG3568@2|Bacteria,1V9H0@1239|Firmicutes,24KPC@186801|Clostridia,42H19@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
YHH3_k127_8488325_1	768672.Desfe_0703	9.656e-11	67.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
YHH3_k127_8488325_2	679926.Mpet_2629	2.744e-09	61.0	COG0492@1|root,arCOG01297@2157|Archaea,2Y84N@28890|Euryarchaeota,2N9Q1@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB-1	-	1.8.1.9	ko:K00384,ko:K03387	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
YHH3_k127_8488325_0	694429.Pyrfu_0023	1.617e-67	241.0	COG0492@1|root,arCOG01296@2157|Archaea,2XPQC@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
YHH3_k127_8488325_3	411460.RUMTOR_01679	0.000134	44.0	COG4191@1|root,COG4191@2|Bacteria,1VCNJ@1239|Firmicutes	1239|Firmicutes	T	Histidine kinase	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MASE3,PAS,PAS_4,PAS_9
YHH3_k127_8497417_0	387631.Asulf_00767	9.6e-16	80.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,245Y7@183980|Archaeoglobi	183980|Archaeoglobi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
YHH3_k127_8526648_0	1220534.B655_2381	5.398e-31	131.0	COG1202@1|root,arCOG03143@2157|Archaea,2Y86H@28890|Euryarchaeota,23PZG@183925|Methanobacteria	183925|Methanobacteria	S	helicase superfamily c-terminal domain	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
YHH3_k127_8529981_2	797209.ZOD2009_12065	1.102e-05	49.0	arCOG02979@1|root,arCOG02979@2157|Archaea,2XT08@28890|Euryarchaeota,23SPH@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8529981_0	415426.Hbut_1257	2.279e-89	311.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
YHH3_k127_8529981_1	273075.Ta0890	1.947e-23	106.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,24255@183967|Thermoplasmata	183967|Thermoplasmata	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
YHH3_k127_8574354_2	1158318.ATXC01000002_gene1596	2.085e-08	64.0	COG3743@1|root,COG3743@2|Bacteria,2G52I@200783|Aquificae	200783|Aquificae	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
YHH3_k127_8574354_1	660470.Theba_2261	4.536e-36	141.0	2DH26@1|root,2ZY4Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
YHH3_k127_8574354_0	269797.Mbar_A0543	4.513e-239	758.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,2N99D@224756|Methanomicrobia	224756|Methanomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
YHH3_k127_8584793_0	1265503.KB905160_gene2894	9.195e-20	90.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,2Q81C@267889|Colwelliaceae	1236|Gammaproteobacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
YHH3_k127_8606533_2	1500281.JQKZ01000001_gene1223	2.531e-18	90.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,1I2SS@117743|Flavobacteriia,3ZRZI@59732|Chryseobacterium	976|Bacteroidetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
YHH3_k127_8606533_1	351160.RCIX1080	7.832e-19	91.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
YHH3_k127_8606533_0	1254432.SCE1572_32355	4.925e-34	135.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WP23@28221|Deltaproteobacteria,2Z0GF@29|Myxococcales	28221|Deltaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep
YHH3_k127_8658567_1	5722.XP_001323626.1	8.856e-30	124.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	-	-	-	ko:K07874,ko:K07901	ko04144,ko04152,ko04530,ko04972,ko05134,map04144,map04152,map04530,map04972,map05134	-	-	-	ko00000,ko00001,ko03036,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_8658567_0	161934.XP_010667311.1	2.512e-32	133.0	KOG0084@1|root,KOG0084@2759|Eukaryota,37JSX@33090|Viridiplantae,3GAR8@35493|Streptophyta	35493|Streptophyta	U	Ras-related protein	-	GO:0000139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0006810,GO:0006888,GO:0008150,GO:0012505,GO:0016020,GO:0016192,GO:0031090,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048193,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0098588,GO:0098791,GO:0098827	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_8658567_2	1463887.KL590014_gene5080	4.751e-07	54.0	COG3831@1|root,COG3831@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_M,DNA_ligase_OB_2,WGR
YHH3_k127_8658567_3	1280390.CBQR020000097_gene2196	0.0001627	53.0	2E6H4@1|root,3314B@2|Bacteria,1VW5U@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8662640_1	324602.Caur_3149	0.0002561	53.0	28JTH@1|root,2Z9IS@2|Bacteria,2G9N8@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8662640_0	649638.Trad_0935	6.668e-28	127.0	28JTH@1|root,2Z9IS@2|Bacteria,1WMBE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8663477_0	913325.N799_07125	0.0001259	47.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1X37Z@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate	gph	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
YHH3_k127_8731266_0	604354.TSIB_0244	2.009e-41	161.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,243H9@183968|Thermococci	183968|Thermococci	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
YHH3_k127_8736362_0	946235.CAER01000070_gene2759	6.917e-15	81.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,4HJMF@91061|Bacilli,23KRB@182709|Oceanobacillus	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
YHH3_k127_8748508_18	358396.C445_10317	1.542e-05	50.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYBT@28890|Euryarchaeota,23W1N@183963|Halobacteria	183963|Halobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
YHH3_k127_8748508_12	224719.Abm4_1254	2.296e-26	113.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota	28890|Euryarchaeota	J	Binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
YHH3_k127_8748508_0	99158.XP_008882380.1	1.464e-113	384.0	COG0201@1|root,KOG1373@2759|Eukaryota,3Y9GN@5794|Apicomplexa,3YIXE@5796|Coccidia,3YV0B@5809|Sarcocystidae	5794|Apicomplexa	U	Plug domain of Sec61p	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K10956	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Plug_translocon,SecY
YHH3_k127_8748508_6	579137.Metvu_0207	2.161e-46	173.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,23Q7F@183939|Methanococci	183939|Methanococci	F	ATP-AMP transphosphorylase	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
YHH3_k127_8748508_17	868131.MSWAN_1444	2.863e-08	58.0	COG2174@1|root,arCOG04168@2157|Archaea,2Y0IH@28890|Euryarchaeota,23PPB@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eL34 family	rpl34e	-	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
YHH3_k127_8748508_8	243232.MJ_0656	1.64e-44	167.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,23QTJ@183939|Methanococci	183939|Methanococci	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
YHH3_k127_8748508_13	368408.Tpen_0462	1.009e-25	109.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
YHH3_k127_8748508_1	269797.Mbar_A0082	2.677e-110	368.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
YHH3_k127_8748508_16	395961.Cyan7425_2227	1.862e-11	76.0	COG4447@1|root,COG4447@2|Bacteria,1G17T@1117|Cyanobacteria,3KG5P@43988|Cyanothece	1117|Cyanobacteria	S	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity	ycf48	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
YHH3_k127_8748508_7	573064.Mefer_1081	1.735e-45	170.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,23QSJ@183939|Methanococci	183939|Methanococci	J	pre-rRNA processing protein involved in ribosome biogenesis	-	GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
YHH3_k127_8748508_19	673860.AciM339_0379	0.0004335	47.0	arCOG06415@1|root,arCOG06415@2157|Archaea	2157|Archaea	L	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	zf-HIT
YHH3_k127_8748508_2	633148.Tagg_0667	1.4e-101	346.0	COG1571@1|root,arCOG01115@2157|Archaea,2XPN1@28889|Crenarchaeota	28889|Crenarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
YHH3_k127_8748508_5	342949.PNA2_0222	6.03e-55	195.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,243ZQ@183968|Thermococci	183968|Thermococci	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
YHH3_k127_8748508_11	330779.Saci_0081	2.899e-41	160.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
YHH3_k127_8748508_10	694429.Pyrfu_1972	1.637e-42	160.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
YHH3_k127_8748508_15	81824.XP_001746875.1	1.388e-12	78.0	COG1100@1|root,KOG0072@2759|Eukaryota,38G98@33154|Opisthokonta	33154|Opisthokonta	U	activation of phospholipase D activity	ARL1	GO:0000045,GO:0000139,GO:0000166,GO:0001505,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006403,GO:0006605,GO:0006623,GO:0006810,GO:0006836,GO:0006886,GO:0006892,GO:0006893,GO:0006897,GO:0006914,GO:0006950,GO:0006996,GO:0007029,GO:0007030,GO:0007033,GO:0007034,GO:0007154,GO:0007267,GO:0007268,GO:0007269,GO:0007275,GO:0007431,GO:0007444,GO:0008047,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009888,GO:0009987,GO:0010256,GO:0010517,GO:0010518,GO:0012505,GO:0015031,GO:0015833,GO:0015931,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019748,GO:0019904,GO:0022607,GO:0023052,GO:0023061,GO:0030234,GO:0030334,GO:0031090,GO:0031503,GO:0031584,GO:0031984,GO:0032258,GO:0032386,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032588,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0033157,GO:0033227,GO:0033363,GO:0033365,GO:0033554,GO:0034067,GO:0034497,GO:0034613,GO:0034629,GO:0034976,GO:0035220,GO:0035272,GO:0035295,GO:0035639,GO:0036094,GO:0036465,GO:0040012,GO:0042147,GO:0042886,GO:0043001,GO:0043085,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044093,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0048193,GO:0048488,GO:0048513,GO:0048731,GO:0048732,GO:0048856,GO:0050657,GO:0050658,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051223,GO:0051234,GO:0051236,GO:0051270,GO:0051336,GO:0051345,GO:0051641,GO:0051649,GO:0051716,GO:0060191,GO:0060193,GO:0060341,GO:0060429,GO:0060627,GO:0060628,GO:0061024,GO:0061919,GO:0061951,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070727,GO:0070861,GO:0070925,GO:0071702,GO:0071705,GO:0071840,GO:0072594,GO:0072657,GO:0072659,GO:0072665,GO:0072666,GO:0090087,GO:0090150,GO:0090158,GO:0097159,GO:0097367,GO:0098588,GO:0098657,GO:0098772,GO:0098791,GO:0098876,GO:0098916,GO:0099003,GO:0099504,GO:0099536,GO:0099537,GO:0099643,GO:1901265,GO:1901363,GO:1903292,GO:1903827,GO:1905037,GO:1990778,GO:2000145	-	ko:K07942	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
YHH3_k127_8748508_14	227086.JGI_V11_50972	2.391e-13	80.0	COG1100@1|root,KOG0071@2759|Eukaryota	2759|Eukaryota	L	Belongs to the small GTPase superfamily. Arf family	ARL15	-	-	ko:K07937,ko:K07941,ko:K17201	ko04014,ko04072,ko04144,ko04666,ko05110,ko05134,map04014,map04072,map04144,map04666,map05110,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Arf
YHH3_k127_8748508_3	556261.HMPREF0240_02109	1.559e-65	239.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,36EB6@31979|Clostridiaceae	186801|Clostridia	EJ	L-asparaginase	ansA	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
YHH3_k127_8748508_9	935948.KE386494_gene869	3.407e-44	176.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia,42GGS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
YHH3_k127_8748508_4	192952.MM_0306	3.418e-64	231.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
YHH3_k127_8753852_3	118161.KB235922_gene2345	2.439e-06	51.0	COG0454@1|root,COG0456@2|Bacteria,1G5GC@1117|Cyanobacteria,3VJMH@52604|Pleurocapsales	1117|Cyanobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
YHH3_k127_8753852_0	702450.CUW_0122	4.883e-47	179.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	yqeF	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
YHH3_k127_8753852_1	945713.IALB_1132	1.415e-35	144.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
YHH3_k127_8753852_4	63577.G9NJH9	0.0004705	50.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CAZ@33154|Opisthokonta,3NVJD@4751|Fungi,3QN69@4890|Ascomycota,21525@147550|Sordariomycetes,3TD5R@5125|Hypocreales,3TZ1G@5129|Hypocreaceae	4751|Fungi	S	Anaphase-promoting complex, cyclosome, subunit 3	SSN6	GO:0000122,GO:0000228,GO:0000785,GO:0000790,GO:0000988,GO:0000989,GO:0001076,GO:0001190,GO:0001191,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0006139,GO:0006323,GO:0006325,GO:0006333,GO:0006338,GO:0006342,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016458,GO:0016584,GO:0017053,GO:0018130,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031497,GO:0031974,GO:0031981,GO:0032774,GO:0032879,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034728,GO:0035950,GO:0035952,GO:0035953,GO:0035955,GO:0040029,GO:0042304,GO:0042826,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0046483,GO:0046890,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0060255,GO:0062012,GO:0065007,GO:0070013,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0072364,GO:0080090,GO:0080134,GO:0080135,GO:0090087,GO:0090088,GO:0090089,GO:0090304,GO:0090568,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2000531,GO:2000877,GO:2000879,GO:2001020,GO:2001141	-	ko:K06665	ko04011,ko04111,map04011,map04111	-	-	-	ko00000,ko00001,ko03021	-	-	-	TPR_1,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8
YHH3_k127_8753852_2	314315.LCA_1481	9.577e-23	103.0	COG3613@1|root,COG3613@2|Bacteria,1V3SN@1239|Firmicutes,4HH4T@91061|Bacilli,3F6KR@33958|Lactobacillaceae	91061|Bacilli	F	Nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
YHH3_k127_8769534_4	1121920.AUAU01000006_gene269	0.0004295	47.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,NTP_transf_5,Transglut_core,Transglut_core3
YHH3_k127_8769534_1	573063.Metin_0089	2.492e-86	293.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,23QFB@183939|Methanococci	183939|Methanococci	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
YHH3_k127_8769534_3	647113.Metok_0149	5.677e-50	184.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
YHH3_k127_8769534_2	887325.HMPREF0381_2736	2.643e-62	224.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,1HW31@1164882|Lachnoanaerobaculum	186801|Clostridia	I	BadF/BadG/BcrA/BcrD ATPase family	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
YHH3_k127_8769534_0	224325.AF_1958	1.661e-97	332.0	COG1775@1|root,arCOG04464@2157|Archaea,2XZP9@28890|Euryarchaeota,246DT@183980|Archaeoglobi	183980|Archaeoglobi	E	2-hydroxyglutaryl-CoA dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
YHH3_k127_880701_1	186497.PF0703	1.339e-20	95.0	arCOG04883@1|root,arCOG04883@2157|Archaea,2Y2KG@28890|Euryarchaeota,245FR@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_880701_0	573064.Mefer_0765	4.052e-108	365.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,23QGH@183939|Methanococci	183939|Methanococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
YHH3_k127_8813775_1	865861.AZSU01000001_gene378	5.87e-24	103.0	COG2154@1|root,COG2154@2|Bacteria,1VERE@1239|Firmicutes,24NE1@186801|Clostridia,36SAJ@31979|Clostridiaceae	186801|Clostridia	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
YHH3_k127_8813775_0	498761.HM1_3016	1.759e-52	194.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia	186801|Clostridia	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
YHH3_k127_8863994_1	1121926.AXWO01000006_gene2646	7.45e-12	66.0	COG1228@1|root,COG1228@2|Bacteria,2I9IW@201174|Actinobacteria,4EXK1@85014|Glycomycetales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
YHH3_k127_8863994_0	933115.GPDM_10315	1.499e-52	194.0	COG0329@1|root,COG0329@2|Bacteria,1UHED@1239|Firmicutes,4HAUA@91061|Bacilli,26G5T@186818|Planococcaceae	91061|Bacilli	EM	Dihydrodipicolinate synthetase family	ycbC	-	4.2.1.41	ko:K01707	ko00053,ko01100,map00053,map01100	-	R02279	RC00678	ko00000,ko00001,ko01000	-	-	-	DHDPS
YHH3_k127_8873957_1	589924.Ferp_0446	4.758e-61	217.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,246YX@183980|Archaeoglobi	183980|Archaeoglobi	P	TIGRFAM Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
YHH3_k127_8873957_0	368408.Tpen_0976	1.344e-63	228.0	COG0370@1|root,arCOG00359@2157|Archaea,2XPKC@28889|Crenarchaeota	28889|Crenarchaeota	P	nucleoside recognition domain protein	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
YHH3_k127_8873957_3	69014.TK0715	1.109e-06	56.0	COG1918@1|root,arCOG02102@2157|Archaea,2Y1KQ@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM FeoA family protein	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
YHH3_k127_8873957_2	374847.Kcr_0555	2.34e-40	167.0	COG3875@1|root,arCOG02046@2157|Archaea	2157|Archaea	L	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
YHH3_k127_8874013_2	1041930.Mtc_0454	8.767e-28	115.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,2N99Z@224756|Methanomicrobia	224756|Methanomicrobia	F	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
YHH3_k127_8874013_1	1151117.AJLF01000003_gene630	2.467e-68	239.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
YHH3_k127_8874013_3	1089553.Tph_c15740	3.017e-09	59.0	COG4231@1|root,COG4231@2|Bacteria,1UN0W@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
YHH3_k127_8874013_0	1266925.JHVX01000001_gene2544	5.145e-131	432.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,372T7@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Alpha-amylase domain	aglA	-	3.2.1.10,3.2.1.20	ko:K01182,ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01718,R01791,R06087,R06088,R06199	RC00028,RC00049,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
YHH3_k127_8920889_1	1184251.TCELL_1258	0.0001739	50.0	COG0611@1|root,arCOG00638@2157|Archaea,2XQYG@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
YHH3_k127_8920889_0	1041930.Mtc_0743	6.568e-145	478.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
YHH3_k127_894682_0	479434.Sthe_3293	6.918e-176	563.0	COG0154@1|root,COG0154@2|Bacteria,2G7KI@200795|Chloroflexi,27YVS@189775|Thermomicrobia	189775|Thermomicrobia	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
YHH3_k127_894682_1	1047013.AQSP01000134_gene1338	7.404e-50	186.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
YHH3_k127_8969363_1	579137.Metvu_1486	7.308e-36	139.0	COG1908@1|root,arCOG02475@2157|Archaea,2XXAU@28890|Euryarchaeota,23QYD@183939|Methanococci	183939|Methanococci	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
YHH3_k127_8969363_3	349161.Dred_0877	2.373e-11	77.0	COG0675@1|root,COG0675@2|Bacteria,1TT4J@1239|Firmicutes,24CV7@186801|Clostridia	186801|Clostridia	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_8969363_2	304371.MCP_2203	2.223e-34	142.0	COG1266@1|root,arCOG02766@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
YHH3_k127_8969363_0	1121324.CLIT_2c00570	8.102e-68	237.0	COG1896@1|root,COG1896@2|Bacteria,1V3MK@1239|Firmicutes,24IBW@186801|Clostridia	186801|Clostridia	D	Psort location Cytoplasmic, score 8.87	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
YHH3_k127_8976437_1	519989.ECTPHS_04453	0.0001307	48.0	COG1842@1|root,COG1842@2|Bacteria,1QW5I@1224|Proteobacteria	1224|Proteobacteria	KT	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
YHH3_k127_8976437_0	1283284.AZUK01000001_gene2478	3.975e-12	78.0	COG5316@1|root,COG5316@2|Bacteria,1N0IJ@1224|Proteobacteria,1S6FA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
YHH3_k127_8989961_1	670487.Ocepr_1132	1.911e-10	65.0	COG1694@1|root,COG1694@2|Bacteria	2|Bacteria	FG	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_8989961_0	399550.Smar_0880	4.587e-22	105.0	COG2517@1|root,arCOG04359@2157|Archaea,2XR9E@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM t-RNA-binding domain protein	-	-	-	ko:K07135	-	-	-	-	ko00000	-	-	-	tRNA_bind
YHH3_k127_9012182_7	386456.JQKN01000013_gene3067	4.683e-26	110.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23P09@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
YHH3_k127_9012182_6	523845.AQXV01000025_gene1493	1.352e-39	156.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23QQD@183939|Methanococci	183939|Methanococci	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
YHH3_k127_9012182_3	186497.PF1763	5.29e-92	316.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,242M3@183968|Thermococci	183968|Thermococci	S	gtp1 obg	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
YHH3_k127_9012182_10	419665.Maeo_0669	5.624e-08	61.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,23QED@183939|Methanococci	183939|Methanococci	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
YHH3_k127_9012182_2	342949.PNA2_0288	1.226e-150	488.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
YHH3_k127_9012182_5	1365176.N186_06990	6.62e-44	164.0	COG1781@1|root,arCOG04229@2157|Archaea,2XQJR@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
YHH3_k127_9012182_9	272844.PAB1184	1.456e-13	75.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y1TB@28890|Euryarchaeota,244C3@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
YHH3_k127_9012182_0	529709.PYCH_15740	4.951e-228	721.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3
YHH3_k127_9012182_4	511051.CSE_03210	3.108e-52	190.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	-	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
YHH3_k127_9012182_1	342949.PNA2_0837	3.493e-199	630.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
YHH3_k127_9012182_8	1227488.C477_05822	1.075e-16	90.0	COG0343@1|root,arCOG00996@1|root,arCOG03726@1|root,arCOG00989@2157|Archaea,arCOG00996@2157|Archaea,arCOG03726@2157|Archaea,2XYR7@28890|Euryarchaeota,23XDR@183963|Halobacteria	183963|Halobacteria	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9012645_1	1105031.HMPREF1141_0161	2.294e-09	58.0	COG3384@1|root,COG3384@2|Bacteria,1TSRZ@1239|Firmicutes,24B3B@186801|Clostridia,36ENN@31979|Clostridiaceae	186801|Clostridia	S	Extradiol ring-cleavage dioxygenase class III protein subunit B	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
YHH3_k127_9012645_2	316067.Geob_3036	1.88e-08	61.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria,43U1H@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
YHH3_k127_9012645_0	593117.TGAM_0091	2.361e-27	121.0	COG0834@1|root,arCOG01799@2157|Archaea,2XUEH@28890|Euryarchaeota,244ZU@183968|Thermococci	183968|Thermococci	E	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
YHH3_k127_9039654_0	342949.PNA2_1342	1.323e-41	159.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,243TQ@183968|Thermococci	183968|Thermococci	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD1	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
YHH3_k127_9039654_1	298655.KI912266_gene2368	2.884e-20	92.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4ERJQ@85013|Frankiales	201174|Actinobacteria	C	acyl-CoA dehydrogenase	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
YHH3_k127_9066063_0	521011.Mpal_0671	1.417e-42	164.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
YHH3_k127_9066063_1	1041930.Mtc_2006	1.625e-07	64.0	COG1404@1|root,COG1470@1|root,arCOG00702@2157|Archaea,arCOG02081@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
YHH3_k127_9077535_1	339860.Msp_1014	5.476e-49	180.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
YHH3_k127_9077535_0	386456.JQKN01000001_gene1960	1.756e-92	312.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23NJW@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
YHH3_k127_9077535_2	1094980.Mpsy_1362	3.674e-05	55.0	COG2512@1|root,arCOG00377@2157|Archaea,2XY2E@28890|Euryarchaeota	28890|Euryarchaeota	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
YHH3_k127_9092007_0	666510.ASAC_0729	2.938e-11	72.0	arCOG03727@1|root,arCOG03727@2157|Archaea,2XRGX@28889|Crenarchaeota	28889|Crenarchaeota	L	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,NERD
YHH3_k127_9092007_2	1487923.DP73_02805	0.0005267	51.0	COG0288@1|root,COG0288@2|Bacteria,1V0AW@1239|Firmicutes,249P8@186801|Clostridia,2607R@186807|Peptococcaceae	186801|Clostridia	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
YHH3_k127_9092007_1	1094980.Mpsy_2609	8.977e-05	49.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT8Z@28890|Euryarchaeota,2NA1D@224756|Methanomicrobia	224756|Methanomicrobia	H	RimK domain protein ATP-grasp	-	-	6.3.2.33	ko:K05844,ko:K15740	ko00790,map00790	-	R09594	RC00064,RC00141	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK
YHH3_k127_9129756_0	1029823.AFIE01000007_gene1868	4.376e-06	55.0	COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,1S5RX@1236|Gammaproteobacteria,3NNMQ@468|Moraxellaceae	1236|Gammaproteobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
YHH3_k127_9130267_5	715451.ambt_02580	3.286e-05	57.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	-
YHH3_k127_9130267_4	497964.CfE428DRAFT_4431	6.516e-07	63.0	COG1361@1|root,COG1520@1|root,COG1572@1|root,COG3227@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1572@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	-	-	ko:K20274	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	CHU_C,FTP,PQQ_2,Peptidase_M36
YHH3_k127_9130267_6	479433.Caci_5177	0.0003727	54.0	COG5426@1|root,COG5426@2|Bacteria,2GKG4@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9130267_2	523850.TON_0636	1.243e-07	65.0	arCOG01314@1|root,arCOG03256@1|root,arCOG01314@2157|Archaea,arCOG03256@2157|Archaea,2Y7MH@28890|Euryarchaeota,243S6@183968|Thermococci	183968|Thermococci	L	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
YHH3_k127_9130267_3	715451.ambt_02580	4.944e-07	63.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	-
YHH3_k127_9130267_1	370438.PTH_1555	9.2e-92	310.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,2611F@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
YHH3_k127_9130267_0	1280692.AUJL01000004_gene732	2.334e-102	349.0	COG2317@1|root,COG2317@2|Bacteria,1TPS6@1239|Firmicutes,249NK@186801|Clostridia,36F32@31979|Clostridiaceae	186801|Clostridia	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
YHH3_k127_9151881_11	123214.PERMA_0491	7.912e-05	56.0	COG0433@1|root,COG1502@1|root,COG0433@2|Bacteria,COG1502@2|Bacteria,2G3QJ@200783|Aquificae	200783|Aquificae	I	Type IV secretion-system coupling protein DNA-binding domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,PLDc_2
YHH3_k127_9151881_7	339860.Msp_0857	2.538e-39	156.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
YHH3_k127_9151881_8	673860.AciM339_0977	8.309e-39	147.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,3F2QH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
YHH3_k127_9151881_2	1042877.GQS_01015	5.552e-171	555.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
YHH3_k127_9151881_5	1385514.N782_11650	8.826e-41	163.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,2Y96P@289201|Pontibacillus	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
YHH3_k127_9151881_12	515622.bpr_I0054	0.0001018	47.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,4BXKQ@830|Butyrivibrio	186801|Clostridia	E	Aminotransferase class-V	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
YHH3_k127_9151881_9	877455.Metbo_0289	4.662e-25	117.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
YHH3_k127_9151881_10	1459636.NTE_00083	1.91e-05	54.0	arCOG04038@1|root,arCOG04038@2157|Archaea,41SQU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9151881_3	1047013.AQSP01000045_gene108	9.132e-141	459.0	COG1748@1|root,COG1748@2|Bacteria,2NNZ1@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lys2	-	1.5.1.10	ko:K00293	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R02315	RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
YHH3_k127_9151881_4	1047013.AQSP01000045_gene109	6.254e-129	425.0	COG0686@1|root,COG0686@2|Bacteria,2NNTE@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	sdh	-	1.5.1.7,1.5.1.8,1.5.1.9	ko:K00290,ko:K14157	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R00716,R02313	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
YHH3_k127_9151881_1	673860.AciM339_0762	4.9e-179	580.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
YHH3_k127_9151881_6	484019.THA_952	5.017e-40	155.0	COG1014@1|root,COG1014@2|Bacteria,2GEBN@200918|Thermotogae	200918|Thermotogae	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
YHH3_k127_9151881_0	868131.MSWAN_2243	2.52e-191	623.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
YHH3_k127_9176698_2	1173028.ANKO01000106_gene307	4.375e-18	91.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
YHH3_k127_9176698_0	1121904.ARBP01000003_gene6365	1.114e-71	254.0	COG0498@1|root,COG0498@2|Bacteria,4NKWI@976|Bacteroidetes,47SIW@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
YHH3_k127_9176698_5	1270196.JCKI01000003_gene2257	0.0006535	49.0	COG0454@1|root,COG0456@2|Bacteria,4NPAS@976|Bacteroidetes,1IX8V@117747|Sphingobacteriia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
YHH3_k127_9176698_1	1191523.MROS_1829	2.241e-68	244.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
YHH3_k127_9176698_4	1151117.AJLF01000001_gene1098	1.941e-10	73.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,243XG@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9176698_3	944565.HMPREF9127_0768	3.893e-16	84.0	290DM@1|root,2ZN2Z@2|Bacteria	2|Bacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
YHH3_k127_9185314_0	457570.Nther_0725	6.826e-38	147.0	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia	186801|Clostridia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
YHH3_k127_9185314_1	536227.CcarbDRAFT_3750	5.001e-19	98.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,249II@186801|Clostridia,36GEZ@31979|Clostridiaceae	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
YHH3_k127_9205998_5	933262.AXAM01000002_gene505	5.588e-07	59.0	COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,42SMY@68525|delta/epsilon subdivisions,2WPKE@28221|Deltaproteobacteria,2MNK4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_2,PAS_4
YHH3_k127_9205998_0	387631.Asulf_00269	5.88e-164	528.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,245Q0@183980|Archaeoglobi	183980|Archaeoglobi	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
YHH3_k127_9205998_2	177437.HRM2_16770	9.344e-77	274.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
YHH3_k127_9205998_3	1114856.C496_12237	5.145e-21	104.0	COG2074@1|root,arCOG01967@2157|Archaea,2XVZC@28890|Euryarchaeota	28890|Euryarchaeota	F	2-phosphoglycerate kinase	pgk2	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	AAA_18,ATP-cone
YHH3_k127_9205998_4	673860.AciM339_0279	3.091e-12	73.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y72Y@28890|Euryarchaeota,3F3AT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
YHH3_k127_9205998_1	592015.HMPREF1705_00414	3.452e-133	434.0	COG0436@1|root,COG0436@2|Bacteria,3TARZ@508458|Synergistetes	508458|Synergistetes	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
YHH3_k127_9205998_6	358681.BBR47_26160	0.0004981	44.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,4HF9S@91061|Bacilli,26U6I@186822|Paenibacillaceae	91061|Bacilli	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
YHH3_k127_9219658_3	589924.Ferp_0839	4.411e-17	89.0	COG1908@1|root,arCOG02475@2157|Archaea,2XZDA@28890|Euryarchaeota,246CR@183980|Archaeoglobi	183980|Archaeoglobi	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
YHH3_k127_9219658_1	1121422.AUMW01000036_gene2696	1.594e-117	414.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2
YHH3_k127_9219658_0	1265505.ATUG01000002_gene1901	1.926e-127	419.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
YHH3_k127_9219658_4	927677.ALVU02000001_gene1903	4.567e-05	47.0	COG0662@1|root,COG0662@2|Bacteria,1G5PK@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
YHH3_k127_9219658_2	1220534.B655_0574	9.891e-23	98.0	COG0662@1|root,arCOG03003@2157|Archaea,2Y1J0@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
YHH3_k127_9222621_0	665571.STHERM_c04570	6.531e-103	342.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J5JP@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
YHH3_k127_9249028_0	374847.Kcr_1452	8.676e-37	146.0	COG1697@1|root,arCOG04143@2157|Archaea	2157|Archaea	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
YHH3_k127_9254293_0	7165.AGAP001676-PA	4.242e-141	459.0	COG5277@1|root,KOG0676@2759|Eukaryota,38C0D@33154|Opisthokonta,3BBGP@33208|Metazoa,3CRBJ@33213|Bilateria,41Y31@6656|Arthropoda,3SQPB@50557|Insecta,455GY@7147|Diptera,45F7T@7148|Nematocera	33208|Metazoa	Z	Belongs to the actin family	ACTB	GO:0003674,GO:0005198,GO:0005200,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005856,GO:0005884,GO:0005886,GO:0005912,GO:0005924,GO:0005925,GO:0006996,GO:0007010,GO:0007015,GO:0008150,GO:0009653,GO:0009987,GO:0010927,GO:0014866,GO:0015629,GO:0016020,GO:0016043,GO:0022607,GO:0030029,GO:0030036,GO:0030054,GO:0030055,GO:0030154,GO:0030239,GO:0031032,GO:0032502,GO:0032989,GO:0042692,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0061061,GO:0070161,GO:0070925,GO:0071689,GO:0071840,GO:0071944,GO:0097433,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0099513	-	ko:K05692	ko04015,ko04145,ko04210,ko04390,ko04391,ko04510,ko04520,ko04530,ko04611,ko04670,ko04714,ko04745,ko04810,ko04919,ko04921,ko05100,ko05110,ko05130,ko05131,ko05132,ko05164,ko05205,ko05225,ko05410,ko05412,ko05414,ko05416,ko05418,map04015,map04145,map04210,map04390,map04391,map04510,map04520,map04530,map04611,map04670,map04714,map04745,map04810,map04919,map04921,map05100,map05110,map05130,map05131,map05132,map05164,map05205,map05225,map05410,map05412,map05414,map05416,map05418	-	-	-	ko00000,ko00001,ko03019,ko03021,ko03029,ko03036,ko04147,ko04812	-	-	-	Actin
YHH3_k127_9254293_2	368407.Memar_1710	5.692e-27	119.0	COG0571@1|root,arCOG03457@2157|Archaea	368407.Memar_1710|-	K	PFAM Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9254293_1	195522.BD01_0598	2.418e-45	183.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2433G@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
YHH3_k127_9287924_2	589865.DaAHT2_0111	1.026e-38	149.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42R4A@68525|delta/epsilon subdivisions,2WM9Z@28221|Deltaproteobacteria,2MJDE@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Silent information regulator protein Sir2	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
YHH3_k127_9287924_4	1089553.Tph_c21120	4.561e-27	118.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,42GBG@68295|Thermoanaerobacterales	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
YHH3_k127_9287924_0	1209989.TepiRe1_1197	1.855e-239	755.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,42F10@68295|Thermoanaerobacterales	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
YHH3_k127_9287924_1	95619.PM1_0203435	9.614e-89	304.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
YHH3_k127_9287924_3	56780.SYN_00663	1.778e-38	150.0	COG1751@1|root,COG1751@2|Bacteria,1RBXI@1224|Proteobacteria,42R3D@68525|delta/epsilon subdivisions,2WMRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
YHH3_k127_9287924_5	649639.Bcell_2302	6.017e-14	78.0	COG1695@1|root,COG1695@2|Bacteria,1V4NA@1239|Firmicutes,4HHWW@91061|Bacilli,1ZINR@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
YHH3_k127_9287924_6	420246.GTNG_1439	9.02e-13	78.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1WE27@129337|Geobacillus	91061|Bacilli	EGP	LacY proton/sugar symporter	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
YHH3_k127_9300787_1	98439.AJLL01000033_gene3262	2.064e-07	62.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1JJWZ@1189|Stigonemataceae	1117|Cyanobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
YHH3_k127_9324894_2	797210.Halxa_2445	2.419e-10	62.0	COG1234@1|root,arCOG00500@2157|Archaea,2XTUD@28890|Euryarchaeota,23STE@183963|Halobacteria	183963|Halobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
YHH3_k127_9324894_1	886293.Sinac_1816	2.81e-42	177.0	COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_3
YHH3_k127_9324894_3	314230.DSM3645_23011	1.551e-08	63.0	arCOG05710@1|root,33AIT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9324894_0	8010.XP_010869643.1	4.899e-99	342.0	COG0339@1|root,KOG2089@2759|Eukaryota,38SFI@33154|Opisthokonta,3B98M@33208|Metazoa,3CT8Z@33213|Bilateria,47ZCM@7711|Chordata,492KW@7742|Vertebrata,49YGV@7898|Actinopterygii	33208|Metazoa	O	Thimet oligopeptidase	THOP1	GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016567,GO:0016787,GO:0019538,GO:0023052,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032446,GO:0033218,GO:0034641,GO:0035556,GO:0036211,GO:0042277,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0070013,GO:0070647,GO:0071704,GO:0140096,GO:1901564	3.4.24.15,3.4.24.16	ko:K01392,ko:K01393	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
YHH3_k127_9331199_0	693661.Arcve_1383	6.138e-60	214.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,24632@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
YHH3_k127_9331199_4	525257.HMPREF0204_14167	1.082e-13	85.0	COG2234@1|root,COG2234@2|Bacteria,4NENF@976|Bacteroidetes,1HX25@117743|Flavobacteriia,3ZQJZ@59732|Chryseobacterium	976|Bacteroidetes	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
YHH3_k127_9331199_3	87626.PTD2_00666	4.287e-25	122.0	COG3266@1|root,COG4932@1|root,COG5183@1|root,COG3266@2|Bacteria,COG4932@2|Bacteria,COG5183@2|Bacteria,1PS4F@1224|Proteobacteria,1RZWB@1236|Gammaproteobacteria,2Q2R1@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	A	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,Peptidase_S8,TSP_3
YHH3_k127_9331199_1	195250.CM001776_gene2962	2.397e-48	190.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H0J4@1129|Synechococcus	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
YHH3_k127_9331199_2	1123368.AUIS01000004_gene121	2.245e-30	121.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,1T3Z8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Response regulator receiver	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
YHH3_k127_9335957_0	657309.BXY_43660	8.305e-07	54.0	COG3831@1|root,COG4886@1|root,COG3831@2|Bacteria,COG4886@2|Bacteria,4NQMK@976|Bacteroidetes,2FQ89@200643|Bacteroidia,4APH3@815|Bacteroidaceae	976|Bacteroidetes	S	WGR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	WGR
YHH3_k127_9335957_1	1304275.C41B8_14485	2.998e-06	58.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Ubie_methyltran
YHH3_k127_9402908_0	1231057.AMGD01000020_gene3341	3.486e-35	148.0	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,4HA5I@91061|Bacilli,26E7T@186818|Planococcaceae	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
YHH3_k127_9402908_1	245174.XP_009265971.1	0.0007619	44.0	KOG3121@1|root,KOG3121@2759|Eukaryota,39E2D@33154|Opisthokonta,3NYV1@4751|Fungi,3V0R2@5204|Basidiomycota	4751|Fungi	Z	Dynactin, subunit p25	-	-	-	ko:K10427	ko04962,map04962	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	Hexapep,Hexapep_2
YHH3_k127_9421768_3	693661.Arcve_0039	1.661e-23	106.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2466I@183980|Archaeoglobi	183980|Archaeoglobi	F	thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
YHH3_k127_9421768_4	4920.XP_004202586.1	8.95e-13	81.0	COG1100@1|root,KOG0071@2759|Eukaryota,3A2CM@33154|Opisthokonta,3P36Y@4751|Fungi,3QVRS@4890|Ascomycota,3RUN9@4891|Saccharomycetes,47BS9@766764|Debaryomycetaceae	4751|Fungi	U	Belongs to the small GTPase superfamily. Arf family	-	-	-	ko:K07977	-	-	-	-	ko00000,ko04031	-	-	-	Arf
YHH3_k127_9421768_5	1459636.NTE_02126	2.534e-09	63.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
YHH3_k127_9421768_6	400682.PAC_15714626	4.364e-07	58.0	arCOG02435@1|root,2S2J2@2759|Eukaryota,3A4U8@33154|Opisthokonta,3BS4B@33208|Metazoa	33208|Metazoa	F	deoxyribonucleoside 5'-monophosphate N-glycosidase activity	DNPH1	GO:0001558,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030307,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040008,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045927,GO:0046434,GO:0046483,GO:0046700,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0055086,GO:0065007,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
YHH3_k127_9421768_2	1457250.BBMO01000001_gene306	1.027e-39	160.0	COG0697@1|root,arCOG00271@2157|Archaea,2XT64@28890|Euryarchaeota,23TZT@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
YHH3_k127_9421768_0	453591.Igni_0393	1.215e-182	583.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
YHH3_k127_9421768_1	679926.Mpet_2037	7.658e-64	227.0	COG1254@1|root,arCOG00643@2157|Archaea,2XVIJ@28890|Euryarchaeota	28890|Euryarchaeota	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
YHH3_k127_9439158_0	671065.MetMK1DRAFT_00013110	8.97e-91	314.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
YHH3_k127_9439158_1	1499967.BAYZ01000156_gene556	3.671e-68	239.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
YHH3_k127_94537_0	1163730.FFONT_0454	1.732e-38	154.0	COG0142@1|root,arCOG01726@2157|Archaea,2XPZM@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the FPP GGPP synthase family	fgs	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
YHH3_k127_9466248_1	1378168.N510_01958	1.465e-19	99.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
YHH3_k127_9466248_0	439481.Aboo_1086	7.423e-21	96.0	COG1051@1|root,COG2005@1|root,arCOG00223@2157|Archaea,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,3F39U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
YHH3_k127_947005_0	292459.STH1963	8.155e-39	149.0	COG1247@1|root,COG1247@2|Bacteria,1UIRW@1239|Firmicutes,25EQT@186801|Clostridia	186801|Clostridia	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_947005_1	754027.HMPREF9554_02651	1.873e-14	82.0	2F5DW@1|root,33XZS@2|Bacteria,2J9XX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9470251_2	679926.Mpet_2621	1.998e-59	210.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota,2N9HS@224756|Methanomicrobia	224756|Methanomicrobia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
YHH3_k127_9470251_6	547163.BN979_05955	1.21e-06	59.0	COG4720@1|root,COG4720@2|Bacteria,2GRG5@201174|Actinobacteria	201174|Actinobacteria	S	ECF-type riboflavin transporter, S component	-	-	-	ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.29	-	-	ECF-ribofla_trS
YHH3_k127_9470251_7	526226.Gbro_4606	0.0003587	53.0	28IIF@1|root,2Z8JJ@2|Bacteria,2H9N3@201174|Actinobacteria,4GAU0@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9470251_0	439235.Dalk_0777	2.47e-114	378.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,43AEV@68525|delta/epsilon subdivisions,2WKWE@28221|Deltaproteobacteria,2MJ82@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
YHH3_k127_9470251_5	269797.Mbar_A1627	1.156e-06	61.0	COG3291@1|root,arCOG03383@1|root,arCOG02510@2157|Archaea,arCOG03383@2157|Archaea	2157|Archaea	E	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CBM_6,NosD,PD40,PKD
YHH3_k127_9470251_1	1499967.BAYZ01000100_gene3438	1.037e-84	287.0	COG0500@1|root,COG2226@2|Bacteria,2NR7P@2323|unclassified Bacteria	2|Bacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
YHH3_k127_9470251_4	340177.Cag_0958	3.212e-22	100.0	2DMZP@1|root,32UMQ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
YHH3_k127_9470251_3	547559.Nmag_4109	1.808e-26	115.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
YHH3_k127_9498656_2	562970.Btus_1769	6.836e-96	325.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
YHH3_k127_9498656_5	903818.KI912268_gene2060	7.776e-66	245.0	COG1100@1|root,COG1100@2|Bacteria	2|Bacteria	S	GTP binding	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,DUF697,MMR_HSR1
YHH3_k127_9498656_6	236097.ADG881_3021	7.12e-32	142.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1XN1M@135619|Oceanospirillales	135619|Oceanospirillales	U	COG4962 Flp pilus assembly protein, ATPase CpaF	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
YHH3_k127_9498656_9	1210908.HSB1_47950	2.007e-09	69.0	COG1405@1|root,arCOG01981@2157|Archaea,2XTPF@28890|Euryarchaeota,23TV8@183963|Halobacteria	183963|Halobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
YHH3_k127_9498656_0	868131.MSWAN_0220	4.933e-107	358.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23NP4@183925|Methanobacteria	183925|Methanobacteria	C	ferredoxin oxidoreductase	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
YHH3_k127_9498656_3	694429.Pyrfu_1938	7.164e-84	293.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
YHH3_k127_9498656_10	666510.ASAC_1325	3.801e-08	58.0	COG0640@1|root,arCOG04056@2157|Archaea,2XR0A@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
YHH3_k127_9498656_7	386456.JQKN01000002_gene2598	2.774e-30	130.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,23NZW@183925|Methanobacteria	183925|Methanobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
YHH3_k127_9498656_4	415426.Hbut_0906	1.218e-66	242.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
YHH3_k127_9498656_1	426368.MmarC7_1424	9.73e-106	351.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
YHH3_k127_9498656_8	1158318.ATXC01000001_gene729	8.236e-14	85.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
YHH3_k127_9511366_4	179408.Osc7112_5509	4.934e-05	48.0	COG2445@1|root,COG2445@2|Bacteria,1G949@1117|Cyanobacteria,1HDJ4@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
YHH3_k127_9511366_5	1031288.AXAA01000035_gene207	0.0003059	46.0	COG2445@1|root,COG2445@2|Bacteria,1VF87@1239|Firmicutes,24HS2@186801|Clostridia,36IYH@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
YHH3_k127_9511366_3	1120998.AUFC01000003_gene1536	2.543e-06	53.0	COG1669@1|root,COG1669@2|Bacteria,1VMPV@1239|Firmicutes,24MWT@186801|Clostridia	186801|Clostridia	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
YHH3_k127_9511366_2	269797.Mbar_A2120	1.772e-13	72.0	COG1598@1|root,arCOG02412@2157|Archaea,2Y1KY@28890|Euryarchaeota,2NB5X@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9511366_1	192952.MM_0160	7.364e-16	80.0	arCOG03086@1|root,arCOG03086@2157|Archaea,2Y1C9@28890|Euryarchaeota,2NBA1@224756|Methanomicrobia	224756|Methanomicrobia	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
YHH3_k127_9511366_0	589924.Ferp_2553	4.304e-17	88.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y2YT@28890|Euryarchaeota,246S2@183980|Archaeoglobi	183980|Archaeoglobi	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
YHH3_k127_9546271_0	289376.THEYE_A1860	3.81e-81	280.0	COG0489@1|root,COG0489@2|Bacteria,3J10K@40117|Nitrospirae	40117|Nitrospirae	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
YHH3_k127_9546271_1	485913.Krac_10173	5.741e-23	109.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	-	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
YHH3_k127_9549925_0	671065.MetMK1DRAFT_00016330	3.853e-15	89.0	COG0747@1|root,arCOG01673@2157|Archaea	2157|Archaea	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
YHH3_k127_9549925_1	861299.J421_3231	4.257e-07	52.0	COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
YHH3_k127_9553731_1	574087.Acear_1487	5.964e-67	238.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_9553731_2	272844.PAB2084	1.705e-32	132.0	COG1142@1|root,arCOG01502@2157|Archaea,2XZWR@28890|Euryarchaeota,242V3@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_9
YHH3_k127_9553731_4	376686.Fjoh_1537	8.37e-06	55.0	COG3815@1|root,COG3815@2|Bacteria,4NUF6@976|Bacteroidetes,1IAE2@117743|Flavobacteriia,2NXQE@237|Flavobacterium	976|Bacteroidetes	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
YHH3_k127_9553731_0	868131.MSWAN_2076	1.296e-95	325.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
YHH3_k127_9553731_3	526224.Bmur_2695	2.045e-15	86.0	COG0560@1|root,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	serB	GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	iNJ661.Rv3042c	ACT_6,HAD,Hydrolase
YHH3_k127_9558584_1	572546.Arcpr_1245	5.131e-05	46.0	arCOG04467@1|root,arCOG04467@2157|Archaea	2157|Archaea	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
YHH3_k127_9558584_0	765177.Desmu_0114	7.331e-73	259.0	COG2414@1|root,arCOG00707@2157|Archaea,2XPRY@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_9568115_0	1151117.AJLF01000001_gene1007	0.00012	49.0	arCOG00743@1|root,arCOG00743@2157|Archaea,2Y3FU@28890|Euryarchaeota,2445D@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9577314_0	1111728.ATYS01000001_gene2413	2.711e-16	79.0	COG2227@1|root,COG2227@2|Bacteria,1QYHT@1224|Proteobacteria,1T3QK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
YHH3_k127_958368_3	637389.Acaty_c1293	8.17e-06	51.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,2NBZI@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
YHH3_k127_958368_0	555079.Toce_0383	1.068e-141	474.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
YHH3_k127_958368_1	403833.Pmob_0382	8.131e-37	144.0	COG1142@1|root,COG1142@2|Bacteria,2GE4G@200918|Thermotogae	200918|Thermotogae	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_11
YHH3_k127_958368_2	1047013.AQSP01000140_gene2511	1.454e-35	154.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
YHH3_k127_9598858_2	1150864.MILUP08_44656	0.0001442	51.0	COG1413@1|root,COG1413@2|Bacteria,2IJHS@201174|Actinobacteria,4DFTI@85008|Micromonosporales	201174|Actinobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
YHH3_k127_9598858_0	202698.XP_007384905.1	3.464e-45	178.0	KOG0272@1|root,KOG0272@2759|Eukaryota	2759|Eukaryota	S	U4 snRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,WD40
YHH3_k127_9598858_1	4641.GSMUA_Achr9P00860_001	5.661e-39	151.0	COG1100@1|root,KOG0087@2759|Eukaryota,37JIN@33090|Viridiplantae,3GGID@35493|Streptophyta,3KN4T@4447|Liliopsida	35493|Streptophyta	U	Ras-related protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005794,GO:0008150,GO:0009504,GO:0009987,GO:0012505,GO:0031410,GO:0031982,GO:0042546,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071554,GO:0071840,GO:0097708	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_960697_0	1188256.BASI01000003_gene2504	7.759e-98	324.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3FCH3@34008|Rhodovulum	28211|Alphaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
YHH3_k127_960697_1	1487923.DP73_19050	2.299e-94	317.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
YHH3_k127_9624309_0	1382304.JNIL01000001_gene3061	8.607e-09	63.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
YHH3_k127_9661723_0	1033737.CAEV01000022_gene3286	1.122e-79	276.0	COG1131@1|root,COG1131@2|Bacteria,1UHTY@1239|Firmicutes,24JZH@186801|Clostridia,36UHX@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
YHH3_k127_9661723_1	69014.TK2027	5.82e-17	91.0	COG0842@1|root,arCOG01465@2157|Archaea,2Y68N@28890|Euryarchaeota,243BM@183968|Thermococci	183968|Thermococci	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
YHH3_k127_9661723_2	69014.TK2028	4.229e-10	69.0	COG0842@1|root,arCOG01465@2157|Archaea,2Y2BQ@28890|Euryarchaeota,243PC@183968|Thermococci	183968|Thermococci	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
YHH3_k127_9677382_3	1183377.Py04_1014	2.233e-52	190.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243RX@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
YHH3_k127_9677382_0	391009.Tmel_0561	6.801e-99	333.0	COG0444@1|root,COG0444@2|Bacteria,2GCDR@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
YHH3_k127_9677382_2	1184251.TCELL_1057	3.806e-62	235.0	COG1173@1|root,arCOG00748@2157|Archaea,2XQGC@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_9677382_1	1499967.BAYZ01000132_gene305	4.615e-74	259.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
YHH3_k127_9689607_0	617140.AJZE01000012_gene2679	0.0001273	45.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1XXEY@135623|Vibrionales	135623|Vibrionales	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
YHH3_k127_9726307_0	188626.HMPREF0321_2051	1.353e-35	142.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,1ZVG1@145357|Dermacoccaceae	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
YHH3_k127_9736731_0	215358.XP_010728023.1	1.455e-08	66.0	KOG3780@1|root,KOG3780@2759|Eukaryota,38RDG@33154|Opisthokonta,3BX22@33208|Metazoa,3DDQP@33213|Bilateria,48H9J@7711|Chordata,49E5V@7742|Vertebrata,4A59A@7898|Actinopterygii	33208|Metazoa	S	Arrestin domain-containing protein 3-like	-	-	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
YHH3_k127_9747762_7	1007103.AFHW01000066_gene4056	5.234e-05	55.0	COG2931@1|root,COG2931@2|Bacteria,1V022@1239|Firmicutes,4HFJ6@91061|Bacilli,26SF3@186822|Paenibacillaceae	91061|Bacilli	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
YHH3_k127_9747762_6	42256.RradSPS_0259	1.991e-18	93.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CQHA@84995|Rubrobacteria	84995|Rubrobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
YHH3_k127_9747762_5	195522.BD01_0352	7.968e-25	116.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,242WT@183968|Thermococci	183968|Thermococci	M	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
YHH3_k127_9747762_4	415426.Hbut_0770	1.513e-30	131.0	COG0009@1|root,arCOG01952@2157|Archaea,2XPW0@28889|Crenarchaeota	28889|Crenarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
YHH3_k127_9747762_3	1459636.NTE_02378	8.163e-32	131.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
YHH3_k127_9747762_8	573063.Metin_0462	0.0003097	51.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXWS@28890|Euryarchaeota,23R0B@183939|Methanococci	183939|Methanococci	S	Kinase binding protein CGI-121	-	-	-	-	-	-	-	-	-	-	-	-	CGI-121
YHH3_k127_9747762_2	515635.Dtur_1425	5.084e-42	161.0	COG2236@1|root,COG2236@2|Bacteria	2|Bacteria	F	xanthine phosphoribosyltransferase activity	gpt	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
YHH3_k127_9747762_1	1089553.Tph_c20450	2.024e-134	440.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,42EXG@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
YHH3_k127_9747762_0	340099.Teth39_1488	1.743e-172	554.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,42FDT@68295|Thermoanaerobacterales	186801|Clostridia	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
YHH3_k127_9748156_2	309799.DICTH_1760	3.602e-80	278.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10
YHH3_k127_9748156_0	573063.Metin_0090	2.062e-125	412.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23RI4@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
YHH3_k127_9748156_4	439235.Dalk_1630	2.745e-17	85.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MM2N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
YHH3_k127_9748156_3	1459636.NTE_01818	5.277e-23	104.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
YHH3_k127_9748156_5	1128421.JAGA01000001_gene2345	0.0001309	53.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CARDB,CBM_3,DUF4091,HYR,Kelch_1,MAM,PA14,PKD,Peptidase_M43,Reprolysin_3
YHH3_k127_9748156_1	456320.Mvol_0794	7.792e-90	303.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
YHH3_k127_9750587_0	368408.Tpen_0679	3.073e-144	466.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPXJ@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
YHH3_k127_9767364_1	941639.BCO26_1768	3.876e-33	145.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli,1ZCQN@1386|Bacillus	91061|Bacilli	C	Glycolate oxidase subunit	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iYO844.BSU28680	FAD-oxidase_C,FAD_binding_4
YHH3_k127_9767364_0	756499.Desde_0778	9.567e-69	252.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
YHH3_k127_9782265_0	693661.Arcve_1874	7.072e-93	314.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
YHH3_k127_9782265_2	1499968.TCA2_5312	1.721e-50	185.0	COG0563@1|root,COG0563@2|Bacteria,1V7AW@1239|Firmicutes,4HH8A@91061|Bacilli,26YSV@186822|Paenibacillaceae	91061|Bacilli	F	topology modulation protein	flaR	-	-	-	-	-	-	-	-	-	-	-	AAA_18,ABC_tran
YHH3_k127_9782265_1	1541959.KQ51_00260	2.42e-53	201.0	2E6H4@1|root,3314B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9794695_0	797209.ZOD2009_10665	3.418e-27	130.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,23SBM@183963|Halobacteria	183963|Halobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
YHH3_k127_9796894_0	112098.XP_008613079.1	1.291e-35	153.0	297V5@1|root,2REVD@2759|Eukaryota	2759|Eukaryota	S	WD repeat protein 35. Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_980523_2	1121423.JONT01000001_gene1840	3.312e-33	144.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2
YHH3_k127_980523_0	386456.JQKN01000001_gene2212	1.611e-76	273.0	COG1148@1|root,arCOG02236@2157|Archaea,2XV85@28890|Euryarchaeota,23PDJ@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3	ko:K22480	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
YHH3_k127_980523_1	386456.JQKN01000001_gene1960	2.301e-46	175.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23NJW@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
YHH3_k127_9810114_1	415426.Hbut_1274	1.153e-61	230.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
YHH3_k127_9810114_0	1267535.KB906767_gene2325	1.347e-72	262.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria,2JIZJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
YHH3_k127_9829246_0	523791.Kkor_0746	1.002e-168	545.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1XH52@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
YHH3_k127_9829246_1	929556.Solca_2127	5.454e-31	128.0	COG2020@1|root,COG2020@2|Bacteria,4PGXX@976|Bacteroidetes,1IUNY@117747|Sphingobacteriia	976|Bacteroidetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
YHH3_k127_9829246_2	4920.XP_004199090.1	2.061e-07	59.0	29CJI@1|root,2RJPB@2759|Eukaryota,38BXG@33154|Opisthokonta,3NXGN@4751|Fungi,3QJXF@4890|Ascomycota,3RT68@4891|Saccharomycetes,47APZ@766764|Debaryomycetaceae	4751|Fungi	S	Vacuolar protein sorting-associated protein 62	VPS62	GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005783,GO:0006605,GO:0006623,GO:0006810,GO:0006886,GO:0007034,GO:0008104,GO:0008150,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0031090,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072665,GO:0072666,GO:0098588,GO:0098805,GO:0098852	-	-	-	-	-	-	-	-	-	-	Vps62
YHH3_k127_9836073_2	523841.HFX_0432	8.796e-14	77.0	COG0372@1|root,arCOG04237@2157|Archaea,2XT24@28890|Euryarchaeota,23S1U@183963|Halobacteria	183963|Halobacteria	C	citrate synthase	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
YHH3_k127_9836073_0	33898.JRHJ01000023_gene6755	1.19e-133	434.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
YHH3_k127_9836073_1	871963.Desdi_1475	1.858e-19	101.0	COG0477@1|root,COG2814@2|Bacteria,1VB8Y@1239|Firmicutes,24KIW@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
YHH3_k127_9836073_4	580340.Tlie_1588	3.134e-05	48.0	28XQZ@1|root,2ZJMK@2|Bacteria,3TCGY@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_9836073_3	484019.THA_1394	6.769e-10	59.0	COG0444@1|root,COG0444@2|Bacteria,2GCDR@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
YHH3_k127_9836593_1	857293.CAAU_2440	1.195e-40	166.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,36WTS@31979|Clostridiaceae	186801|Clostridia	P	COG1055 Na H antiporter NhaD and related arsenite permeases	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
YHH3_k127_9836593_2	314271.RB2654_05105	1.125e-07	60.0	2B107@1|root,31TDE@2|Bacteria,1RITJ@1224|Proteobacteria,2U99C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	RNase_Zc3h12a
YHH3_k127_9836593_0	221027.JO40_10885	7.434e-99	328.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
YHH3_k127_9866443_0	1191523.MROS_2656	5.344e-31	133.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
YHH3_k127_9866443_1	3218.PP1S220_23V6.1	5.041e-17	86.0	COG0306@1|root,KOG2493@2759|Eukaryota,37MAB@33090|Viridiplantae,3GGPC@35493|Streptophyta	35493|Streptophyta	P	Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport	-	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0009507,GO:0009526,GO:0009536,GO:0009673,GO:0009941,GO:0015075,GO:0015103,GO:0015114,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031967,GO:0031975,GO:0034220,GO:0035435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K14640	-	-	-	-	ko00000,ko02000	2.A.20.2	-	-	PHO4
YHH3_k127_9866443_2	331113.SNE_A03040	3.845e-16	86.0	COG0306@1|root,COG0306@2|Bacteria,2JFPI@204428|Chlamydiae	204428|Chlamydiae	P	Phosphate	CP_0067	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
YHH3_k127_9870074_7	1828.JOKB01000002_gene629	2.511e-15	80.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria,4FYA5@85025|Nocardiaceae	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
YHH3_k127_9870074_2	1042156.CXIVA_16150	6.509e-71	259.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	BBE,FAD_binding_4
YHH3_k127_9870074_0	903818.KI912269_gene284	6.883e-107	360.0	COG0247@1|root,COG0247@2|Bacteria,3Y3RK@57723|Acidobacteria	57723|Acidobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
YHH3_k127_9870074_1	439235.Dalk_4041	1.458e-96	333.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2WMZ9@28221|Deltaproteobacteria,2MPEE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	pcmI	-	1.17.99.1	ko:K05797	ko00623,ko01100,ko01120,map00623,map01100,map01120	-	R02675,R11194	RC00769	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
YHH3_k127_9870074_9	768710.DesyoDRAFT_4237	1.347e-07	57.0	COG4231@1|root,COG4231@2|Bacteria,1VAJQ@1239|Firmicutes,24MVB@186801|Clostridia,262JW@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
YHH3_k127_9870074_4	1094980.Mpsy_2554	1.599e-26	124.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,2N99C@224756|Methanomicrobia	224756|Methanomicrobia	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	bchP	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3
YHH3_k127_9870074_8	1449353.JQMQ01000005_gene2279	2.753e-09	65.0	COG1695@1|root,COG1695@2|Bacteria,2GMKD@201174|Actinobacteria,2NEHS@228398|Streptacidiphilus	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
YHH3_k127_9870074_6	684949.ATTJ01000001_gene2836	1.695e-15	81.0	COG0454@1|root,COG0454@2|Bacteria,1WJYD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
YHH3_k127_9870074_3	694440.JOMF01000006_gene444	4.079e-29	124.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2NAVQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
YHH3_k127_9908253_1	521011.Mpal_0644	2.971e-08	55.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
YHH3_k127_9908253_0	2850.Phatr51727	1.47e-33	134.0	KOG0084@1|root,KOG0084@2759|Eukaryota,2XFBC@2836|Bacillariophyta	2836|Bacillariophyta	U	Ras of Complex, Roc, domain of DAPkinase	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
YHH3_k127_9956448_0	926569.ANT_27310	1.228e-99	339.0	COG1431@1|root,COG1431@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07578	-	-	-	-	ko00000	-	-	-	Piwi
YHH3_k127_9977898_2	444157.Tneu_0971	0.0001461	47.0	arCOG03714@1|root,arCOG03714@2157|Archaea,2XQWJ@28889|Crenarchaeota	28889|Crenarchaeota	F	ATP cone domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone
YHH3_k127_9977898_0	1459636.NTE_00022	1.742e-36	148.0	COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota	2157|Archaea	K	Transcriptional regulator	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	DUF1724,HTH_20,HTH_5,MarR_2
YHH3_k127_9977898_1	452637.Oter_1881	6.29e-19	93.0	COG1680@1|root,COG4319@1|root,COG1680@2|Bacteria,COG4319@2|Bacteria,46V0A@74201|Verrucomicrobia,3K85Q@414999|Opitutae	414999|Opitutae	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
YHH3_k127_998366_2	43989.cce_3949	0.0008038	46.0	2DN4E@1|root,32VGA@2|Bacteria,1G7ZM@1117|Cyanobacteria,3KIRI@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
YHH3_k127_998366_1	268407.PWYN_18010	2.297e-39	156.0	2DBV7@1|root,2ZB9P@2|Bacteria,1UBN2@1239|Firmicutes,4HEYF@91061|Bacilli,26VBW@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
YHH3_k127_998366_0	1220534.B655_1325	3.51e-92	311.0	COG0604@1|root,arCOG01458@2157|Archaea,2XURG@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
## 2623 queries scanned
## Total time (seconds): 12.38125228881836
## Rate: 211.85 q/s